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Conserved domains on  [gi|57528238|ref|NP_001009641|]
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xaa-Pro dipeptidase [Rattus norvegicus]

Protein Classification

aminopeptidase P family protein( domain architecture ID 10659798)

aminopeptidase family protein P (peptidase M24) cleaves amido-, imido- or amidino-containing bonds, exhibiting a fairly narrow substrate specificity compared to other metallo-aminopeptidases, possibly playing roles in regulation of biological processes

CATH:  3.40.350.10|3.90.230.10
EC:  3.4.11.-
Gene Ontology:  GO:0004177|GO:0016020|GO:0070006|GO:0046872|GO:0006508
MEROPS:  M24
PubMed:  30066404|9434107|12475202

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 192-467 2.38e-127

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


:

Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 369.98  E-value: 2.38e-127
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238 192 LEVLRYTNRISSEAHREVMKAVKVGMKEYEMESLFQHYCYSKGGMRHTSYTCICcsGENAAVLHYGHagapNDRTIKDGD 271
Cdd:cd01087   1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGARLAYSYIVAA--GSNAAILHYVH----NDQPLKDGD 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238 272 ICLFDMGGEYYCFASDITCSFPANGKFTDDQKAIYEAVLRSCRTVMSTMKPGVWWPDMHRLADRIHLEELTRIGLLSGSV 351
Cdd:cd01087  75 LVLIDAGAEYGGYASDITRTFPVNGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIHLLAHRVLAEGLKELGILKGDV 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238 352 DAMLQVHLGAVFMPHGLGHFLGLDVHDVGGYpegveridepgLRSLRTARHLEPGMVLTVEPGIYFIDHLLDQaladpaq 431
Cdd:cd01087 155 DEIVESGAYAKFFPHGLGHYLGLDVHDVGGY-----------LRYLRRARPLEPGMVITIEPGIYFIPDLLDV------- 216

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 57528238 432 acffnqevlQRFRNFGGVRIEEDVVVTDSGMELLTC 467
Cdd:cd01087 217 ---------PEYFRGGGIRIEDDVLVTEDGPENLTR 243
AMP_N smart01011
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 18-155 1.74e-36

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain. However, little or no sequence similarity exists between the two families.


:

Pssm-ID: 198079  Cd Length: 135  Bit Score: 131.21  E-value: 1.74e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238     18 VPLALFALNRQRLCERLrkngavQAGSAVVLQGGEEMQRYCtDTSIIFRQESFFHWAFGVIESGCYGVIDV--DTGKSTL 95
Cdd:smart01011   1 IPAAEYAARRRRLAAKL------FPGSVAVLPAGPEKVRSN-DTDYPFRQDSDFYYLTGFDEPDAVLVLDPsgGGGKSTL 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 57528238     96 FVPRLPASYATWMGKIHSKEHFKEKYAVDDVQYADEIASVLTS--RNPSVLLTLRGVNTDSG 155
Cdd:smart01011  74 FVPPRDPEDELWDGPRLGLEEAKEKFGVDEVYPIDELDAVLPGllAGAGTVYYLLGRDPDLD 135
 
Name Accession Description Interval E-value
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 192-467 2.38e-127

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 369.98  E-value: 2.38e-127
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238 192 LEVLRYTNRISSEAHREVMKAVKVGMKEYEMESLFQHYCYSKGGMRHTSYTCICcsGENAAVLHYGHagapNDRTIKDGD 271
Cdd:cd01087   1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGARLAYSYIVAA--GSNAAILHYVH----NDQPLKDGD 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238 272 ICLFDMGGEYYCFASDITCSFPANGKFTDDQKAIYEAVLRSCRTVMSTMKPGVWWPDMHRLADRIHLEELTRIGLLSGSV 351
Cdd:cd01087  75 LVLIDAGAEYGGYASDITRTFPVNGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIHLLAHRVLAEGLKELGILKGDV 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238 352 DAMLQVHLGAVFMPHGLGHFLGLDVHDVGGYpegveridepgLRSLRTARHLEPGMVLTVEPGIYFIDHLLDQaladpaq 431
Cdd:cd01087 155 DEIVESGAYAKFFPHGLGHYLGLDVHDVGGY-----------LRYLRRARPLEPGMVITIEPGIYFIPDLLDV------- 216

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 57528238 432 acffnqevlQRFRNFGGVRIEEDVVVTDSGMELLTC 467
Cdd:cd01087 217 ---------PEYFRGGGIRIEDDVLVTEDGPENLTR 243
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
178-475 3.14e-74

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 236.25  E-value: 3.14e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238 178 PEIVECRVFKTDMELEVLRYTNRISSEAHREVMKAVKVGMKEYEMESLFQHYCYsKGGMRHTSYTCICCSGENAAVLHYG 257
Cdd:COG0006  65 DLLEELRAIKSPEEIELMRKAARIADAAHEAALAALRPGVTEREVAAELEAAMR-RRGAEGPSFDTIVASGENAAIPHYT 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238 258 hagaPNDRTIKDGDICLFDMGGEYYCFASDITCSFPAnGKFTDDQKAIYEAVLRSCRTVMSTMKPGVWWPDMHRLADRIh 337
Cdd:COG0006 144 ----PTDRPLKPGDLVLIDAGAEYDGYTSDITRTVAV-GEPSDEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAARDV- 217

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238 338 leeLTRIGLlsgsvdamlqvhlgAVFMPHGLGHFLGLDVHDVGGYPEGVERIdepglrslrtarhLEPGMVLTVEPGIYF 417
Cdd:COG0006 218 ---LAEAGY--------------GEYFPHGTGHGVGLDVHEGPQISPGNDRP-------------LEPGMVFTIEPGIYI 267

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 57528238 418 IDhlldqaladpaqacffnqevlqrfrnFGGVRIEEDVVVTDSGMELLTCVPRTVEEI 475
Cdd:COG0006 268 PG--------------------------IGGVRIEDTVLVTEDGAEVLTRLPRELLEL 299
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 178-481 3.92e-71

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 232.69  E-value: 3.92e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238  178 PEIVECRVFKTDMELEVLRYTNRISSEAHREVMKAVKVGMKEYEMESLFQHYcYSKGGMRHTSYTCICCSGENAAVLHYg 257
Cdd:PRK10879 165 PWVHEMRLFKSPEEIAVLRRAGEISALAHTRAMEKCRPGMFEYQLEGEIHHE-FNRHGARYPSYNTIVGSGENGCILHY- 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238  258 hagAPNDRTIKDGDICLFDMGGEYYCFASDITCSFPANGKFTDDQKAIYEAVLRSCRTVMSTMKPGVWWPDMHRLADRIH 337
Cdd:PRK10879 243 ---TENESEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTPAQREIYDIVLESLETSLRLYRPGTSIREVTGEVVRIM 319

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238  338 LEELTRIGLLSGSVDAMLQVHLGAVFMPHGLGHFLGLDVHDVGGYpeGVERidepglrslrtARHLEPGMVLTVEPGIYf 417
Cdd:PRK10879 320 VSGLVKLGILKGDVDQLIAENAHRPFFMHGLSHWLGLDVHDVGVY--GQDR-----------SRILEPGMVLTVEPGLY- 385

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 57528238  418 idhlldqaLADPAqacffnqEVLQRFRNFgGVRIEEDVVVTDSGMELLTC-VPRTVEEIEACMAG 481
Cdd:PRK10879 386 --------IAPDA-------DVPEQYRGI-GIRIEDDIVITETGNENLTAsVVKKPDEIEALMAA 434
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 193-459 2.30e-63

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 204.78  E-value: 2.30e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238   193 EVLRYTNRISSEAHREVMKAVKVGMKEYEMESLFQHYCYSKGGMRHTSYTCICCSGENAAVLHYghagAPNDRTIKDGDI 272
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGARGPAFPPIVASGPNAAIPHY----IPNDRVLKPGDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238   273 CLFDMGGEY-YCFASDITCSFpANGKFTDDQKAIYEAVLRSCRTVMSTMKPGVWWPDMHRLADRIhleeLTRIGLLsgsv 351
Cdd:pfam00557  77 VLIDVGAEYdGGYCSDITRTF-VVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREV----LEEAGLG---- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238   352 damlqvhlgaVFMPHGLGHFLGLDVHdvggypegveriDEPGLRSLRTARHLEPGMVLTVEPGIYFIDhlldqaladpaq 431
Cdd:pfam00557 148 ----------EYFPHGLGHGIGLEVH------------EGPYISRGGDDRVLEPGMVFTIEPGIYFIP------------ 193

                         250       260
                  ....*....|....*....|....*...
gi 57528238   432 acffnqevlqrfrNFGGVRIEEDVVVTD 459
Cdd:pfam00557 194 -------------GWGGVRIEDTVLVTE 208
AMP_N smart01011
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 18-155 1.74e-36

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain. However, little or no sequence similarity exists between the two families.


Pssm-ID: 198079  Cd Length: 135  Bit Score: 131.21  E-value: 1.74e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238     18 VPLALFALNRQRLCERLrkngavQAGSAVVLQGGEEMQRYCtDTSIIFRQESFFHWAFGVIESGCYGVIDV--DTGKSTL 95
Cdd:smart01011   1 IPAAEYAARRRRLAAKL------FPGSVAVLPAGPEKVRSN-DTDYPFRQDSDFYYLTGFDEPDAVLVLDPsgGGGKSTL 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 57528238     96 FVPRLPASYATWMGKIHSKEHFKEKYAVDDVQYADEIASVLTS--RNPSVLLTLRGVNTDSG 155
Cdd:smart01011  74 FVPPRDPEDELWDGPRLGLEEAKEKFGVDEVYPIDELDAVLPGllAGAGTVYYLLGRDPDLD 135
AMP_N pfam05195
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 23-138 1.48e-34

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain (pfam01321). However, little or no sequence similarity exists between the two families.


Pssm-ID: 461581 [Multi-domain]  Cd Length: 121  Bit Score: 125.70  E-value: 1.48e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238    23 FALNRQRLCERLrkngavQAGSAVVLQGGEEMQRYCtDTSIIFRQESFFHWAFGVIESGCYGVI---DVDTGKSTLFVPR 99
Cdd:pfam05195   1 YAERRARLLAKL------PPNSVAILPGAPEKYRNG-DVFYPFRQDSDFYYLTGFNEPDAVLVLeggDIDSGKETLFVPP 73

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 57528238   100 LPASYATWMGKIHSKEHFKEKYAVDDVQYADEIASVLTS 138
Cdd:pfam05195  74 KDPEDEIWDGPRLGPEEAKELFGVDEVYPIDELDEVLPK 112
 
Name Accession Description Interval E-value
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 192-467 2.38e-127

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 369.98  E-value: 2.38e-127
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238 192 LEVLRYTNRISSEAHREVMKAVKVGMKEYEMESLFQHYCYSKGGMRHTSYTCICcsGENAAVLHYGHagapNDRTIKDGD 271
Cdd:cd01087   1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEYEFRSRGARLAYSYIVAA--GSNAAILHYVH----NDQPLKDGD 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238 272 ICLFDMGGEYYCFASDITCSFPANGKFTDDQKAIYEAVLRSCRTVMSTMKPGVWWPDMHRLADRIHLEELTRIGLLSGSV 351
Cdd:cd01087  75 LVLIDAGAEYGGYASDITRTFPVNGKFTDEQRELYEAVLAAQKAAIAACKPGVSYEDIHLLAHRVLAEGLKELGILKGDV 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238 352 DAMLQVHLGAVFMPHGLGHFLGLDVHDVGGYpegveridepgLRSLRTARHLEPGMVLTVEPGIYFIDHLLDQaladpaq 431
Cdd:cd01087 155 DEIVESGAYAKFFPHGLGHYLGLDVHDVGGY-----------LRYLRRARPLEPGMVITIEPGIYFIPDLLDV------- 216

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 57528238 432 acffnqevlQRFRNFGGVRIEEDVVVTDSGMELLTC 467
Cdd:cd01087 217 ---------PEYFRGGGIRIEDDVLVTEDGPENLTR 243
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
178-475 3.14e-74

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 236.25  E-value: 3.14e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238 178 PEIVECRVFKTDMELEVLRYTNRISSEAHREVMKAVKVGMKEYEMESLFQHYCYsKGGMRHTSYTCICCSGENAAVLHYG 257
Cdd:COG0006  65 DLLEELRAIKSPEEIELMRKAARIADAAHEAALAALRPGVTEREVAAELEAAMR-RRGAEGPSFDTIVASGENAAIPHYT 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238 258 hagaPNDRTIKDGDICLFDMGGEYYCFASDITCSFPAnGKFTDDQKAIYEAVLRSCRTVMSTMKPGVWWPDMHRLADRIh 337
Cdd:COG0006 144 ----PTDRPLKPGDLVLIDAGAEYDGYTSDITRTVAV-GEPSDEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAARDV- 217

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238 338 leeLTRIGLlsgsvdamlqvhlgAVFMPHGLGHFLGLDVHDVGGYPEGVERIdepglrslrtarhLEPGMVLTVEPGIYF 417
Cdd:COG0006 218 ---LAEAGY--------------GEYFPHGTGHGVGLDVHEGPQISPGNDRP-------------LEPGMVFTIEPGIYI 267

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 57528238 418 IDhlldqaladpaqacffnqevlqrfrnFGGVRIEEDVVVTDSGMELLTCVPRTVEEI 475
Cdd:COG0006 268 PG--------------------------IGGVRIEDTVLVTEDGAEVLTRLPRELLEL 299
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 178-481 3.92e-71

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 232.69  E-value: 3.92e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238  178 PEIVECRVFKTDMELEVLRYTNRISSEAHREVMKAVKVGMKEYEMESLFQHYcYSKGGMRHTSYTCICCSGENAAVLHYg 257
Cdd:PRK10879 165 PWVHEMRLFKSPEEIAVLRRAGEISALAHTRAMEKCRPGMFEYQLEGEIHHE-FNRHGARYPSYNTIVGSGENGCILHY- 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238  258 hagAPNDRTIKDGDICLFDMGGEYYCFASDITCSFPANGKFTDDQKAIYEAVLRSCRTVMSTMKPGVWWPDMHRLADRIH 337
Cdd:PRK10879 243 ---TENESEMRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTPAQREIYDIVLESLETSLRLYRPGTSIREVTGEVVRIM 319

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238  338 LEELTRIGLLSGSVDAMLQVHLGAVFMPHGLGHFLGLDVHDVGGYpeGVERidepglrslrtARHLEPGMVLTVEPGIYf 417
Cdd:PRK10879 320 VSGLVKLGILKGDVDQLIAENAHRPFFMHGLSHWLGLDVHDVGVY--GQDR-----------SRILEPGMVLTVEPGLY- 385

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 57528238  418 idhlldqaLADPAqacffnqEVLQRFRNFgGVRIEEDVVVTDSGMELLTC-VPRTVEEIEACMAG 481
Cdd:PRK10879 386 --------IAPDA-------DVPEQYRGI-GIRIEDDIVITETGNENLTAsVVKKPDEIEALMAA 434
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 193-459 2.30e-63

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 204.78  E-value: 2.30e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238   193 EVLRYTNRISSEAHREVMKAVKVGMKEYEMESLFQHYCYSKGGMRHTSYTCICCSGENAAVLHYghagAPNDRTIKDGDI 272
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGARGPAFPPIVASGPNAAIPHY----IPNDRVLKPGDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238   273 CLFDMGGEY-YCFASDITCSFpANGKFTDDQKAIYEAVLRSCRTVMSTMKPGVWWPDMHRLADRIhleeLTRIGLLsgsv 351
Cdd:pfam00557  77 VLIDVGAEYdGGYCSDITRTF-VVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREV----LEEAGLG---- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238   352 damlqvhlgaVFMPHGLGHFLGLDVHdvggypegveriDEPGLRSLRTARHLEPGMVLTVEPGIYFIDhlldqaladpaq 431
Cdd:pfam00557 148 ----------EYFPHGLGHGIGLEVH------------EGPYISRGGDDRVLEPGMVFTIEPGIYFIP------------ 193

                         250       260
                  ....*....|....*....|....*...
gi 57528238   432 acffnqevlqrfrNFGGVRIEEDVVVTD 459
Cdd:pfam00557 194 -------------GWGGVRIEDTVLVTE 208
PRK13607 PRK13607
proline dipeptidase; Provisional
 184-466 5.24e-62

proline dipeptidase; Provisional


Pssm-ID: 237444 [Multi-domain]  Cd Length: 443  Bit Score: 208.98  E-value: 5.24e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238  184 RVFKTDMELEVLRYTNRISSEAHREVMKAVKVGMKEYEMEslfQHYCySKGGMRHTS--YTCICCSGENAAVLHY---GH 258
Cdd:PRK13607 159 RAYKTDYELACMREAQKIAVAGHRAAKEAFRAGMSEFDIN---LAYL-TATGQRDNDvpYGNIVALNEHAAVLHYtklDH 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238  259 AGAPNDRTIkdgdicLFDMGGEYYCFASDITCSFPANGK--FTDDQKAIYEAVLRSCrtvmSTMKPGVWWPDMHRLAdri 336
Cdd:PRK13607 235 QAPAEMRSF------LIDAGAEYNGYAADITRTYAAKEDndFAALIKDVNKEQLALI----ATMKPGVSYVDLHIQM--- 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238  337 HL---EELTRIGLLSG-SVDAMLQVHLGAVFMPHGLGHFLGLDVHDVGGYpegveRIDEPGLR--------SLRTARHLE 404
Cdd:PRK13607 302 HQriaKLLRKFQIVTGlSEEAMVEQGITSPFFPHGLGHPLGLQVHDVAGF-----MQDDRGTHlaapekhpYLRCTRVLE 376

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 57528238  405 PGMVLTVEPGIYFIDHLLDQALADPAQAcFFNQEVLQRFRNFGGVRIEEDVVVTDSGMELLT 466
Cdd:PRK13607 377 PGMVLTIEPGLYFIDSLLAPLREGPFSK-HFNWQKIDALKPFGGIRIEDNVVVHENGVENMT 437
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 192-461 8.47e-38

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 137.26  E-value: 8.47e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238 192 LEVLRYTNRISSEAHREVMKAVKVGMKEYEMeSLFQHYCYSKGGMRHTSYTCICCSGENAAVLHyGHAGapnDRTIKDGD 271
Cdd:cd01092   1 IELLRKAARIADKAFEELLEFIKPGMTEREV-AAELEYFMRKLGAEGPSFDTIVASGPNSALPH-GVPS---DRKIEEGD 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238 272 ICLFDMGGEY--YCfaSDITCSFpANGKFTDDQKAIYEAVLRSCRTVMSTMKPGVWWPDMHRLADRIhLEEltrigllSG 349
Cdd:cd01092  76 LVLIDFGAIYdgYC--SDITRTV-AVGEPSDELKEIYEIVLEAQQAAIKAVKPGVTAKEVDKAARDV-IEE-------AG 144

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238 350 svdamlqvhLGAVFmPHGLGHFLGLDVHDvggypegveridEPGLRSlRTARHLEPGMVLTVEPGIYFidhlldqaladP 429
Cdd:cd01092 145 ---------YGEYF-IHRTGHGVGLEVHE------------APYISP-GSDDVLEEGMVFTIEPGIYI-----------P 190

                       250       260       270
                ....*....|....*....|....*....|..
gi 57528238 430 aqacffnqevlqrfrNFGGVRIEEDVVVTDSG 461
Cdd:cd01092 191 ---------------GKGGVRIEDDVLVTEDG 207
AMP_N smart01011
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 18-155 1.74e-36

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain. However, little or no sequence similarity exists between the two families.


Pssm-ID: 198079  Cd Length: 135  Bit Score: 131.21  E-value: 1.74e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238     18 VPLALFALNRQRLCERLrkngavQAGSAVVLQGGEEMQRYCtDTSIIFRQESFFHWAFGVIESGCYGVIDV--DTGKSTL 95
Cdd:smart01011   1 IPAAEYAARRRRLAAKL------FPGSVAVLPAGPEKVRSN-DTDYPFRQDSDFYYLTGFDEPDAVLVLDPsgGGGKSTL 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 57528238     96 FVPRLPASYATWMGKIHSKEHFKEKYAVDDVQYADEIASVLTS--RNPSVLLTLRGVNTDSG 155
Cdd:smart01011  74 FVPPRDPEDELWDGPRLGLEEAKEKFGVDEVYPIDELDAVLPGllAGAGTVYYLLGRDPDLD 135
AMP_N pfam05195
Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the ...
 23-138 1.48e-34

Aminopeptidase P, N-terminal domain; This domain is structurally very similar to the creatinase N-terminal domain (pfam01321). However, little or no sequence similarity exists between the two families.


Pssm-ID: 461581 [Multi-domain]  Cd Length: 121  Bit Score: 125.70  E-value: 1.48e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238    23 FALNRQRLCERLrkngavQAGSAVVLQGGEEMQRYCtDTSIIFRQESFFHWAFGVIESGCYGVI---DVDTGKSTLFVPR 99
Cdd:pfam05195   1 YAERRARLLAKL------PPNSVAILPGAPEKYRNG-DVFYPFRQDSDFYYLTGFNEPDAVLVLeggDIDSGKETLFVPP 73

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 57528238   100 LPASYATWMGKIHSKEHFKEKYAVDDVQYADEIASVLTS 138
Cdd:pfam05195  74 KDPEDEIWDGPRLGPEEAKELFGVDEVYPIDELDEVLPK 112
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 192-461 8.21e-33

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 123.72  E-value: 8.21e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238 192 LEVLRYTNRISSEAHREVMKAVKVGMKEYEMESLFQHYCYSKGGmrHTSYTCICCSGENAAVLHYGhagaPNDRTIKDGD 271
Cdd:cd01066   1 IARLRKAAEIAEAAMAAAAEAIRPGVTEAEVAAAIEQALRAAGG--YPAGPTIVGSGARTALPHYR----PDDRRLQEGD 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238 272 ICLFDMGGEYYCFASDITCSFPaNGKFTDDQKAIYEAVLRSCRTVMSTMKPGVWWPDMHRLADRihleeltrigllsgsv 351
Cdd:cd01066  75 LVLVDLGGVYDGYHADLTRTFV-IGEPSDEQRELYEAVREAQEAALAALRPGVTAEEVDAAARE---------------- 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238 352 daMLQVHLGAVFMPHGLGHFLGLDVHDVGGYPEGveridepglrslrTARHLEPGMVLTVEPGIYFIDHlldqaladpaq 431
Cdd:cd01066 138 --VLEEHGLGPNFGHRTGHGIGLEIHEPPVLKAG-------------DDTVLEPGMVFAVEPGLYLPGG----------- 191

                       250       260       270
                ....*....|....*....|....*....|
gi 57528238 432 acffnqevlqrfrnfGGVRIEEDVVVTDSG 461
Cdd:cd01066 192 ---------------GGVRIEDTVLVTEDG 206
PRK09795 PRK09795
aminopeptidase; Provisional
 184-472 4.94e-23

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 100.40  E-value: 4.94e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238  184 RVFKTDMELEVLRYTNRISSEAHREVMKAVKVGMKEYEMESLFQHYCYSKGGMRhTSYTCICCSGENAAVLHyghaGAPN 263
Cdd:PRK09795 125 RQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSEREIAAELEWFMRQQGAEK-ASFDTIVASGWRGALPH----GKAS 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238  264 DRTIKDGDICLFDMGGEYYCFASDITCSFPANGKFTDDQK----AIYEAVLRSCRTVMSTMKPGVWWPDMHRLADRIhle 339
Cdd:PRK09795 200 DKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAEShplfNVYQIVLQAQLAAISAIRPGVRCQQVDDAARRV--- 276

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238  340 eLTRIGLlsgsvdamlqvhlgAVFMPHGLGHFLGLDVHDvggypegveridEPGLRSLRTARhLEPGMVLTVEPGIYFid 419
Cdd:PRK09795 277 -ITEAGY--------------GDYFGHNTGHAIGIEVHE------------DPRFSPRDTTT-LQPGMLLTVEPGIYL-- 326

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 57528238  420 hlldqaladPAQacffnqevlqrfrnfGGVRIEEDVVVTDSGMELLTCVPRTV 472
Cdd:PRK09795 327 ---------PGQ---------------GGVRIEDVVLVTPQGAEVLYAMPKTV 355
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
 240-461 3.65e-14

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 71.82  E-value: 3.65e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238 240 SYTCICCSGENAAVLHYgHAGAPNDRTIKDGDICLFDMGGEYYCFASDITCSFpANGKFTDDQKAIYEAVLRScrtvmst 319
Cdd:cd01085  53 SFDTISGFGPNGAIVHY-SPTEESNRKISPDGLYLIDSGGQYLDGTTDITRTV-HLGEPTAEQKRDYTLVLKG------- 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238 320 mkpgvwwpdmhrladriHLeELTRIGLLSGS----VDAMLQVHLGAVFM--PHGLGHFLG--LDVHdvggypEGVERIde 391
Cdd:cd01085 124 -----------------HI-ALARAKFPKGTtgsqLDALARQPLWKAGLdyGHGTGHGVGsfLNVH------EGPQSI-- 177

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238 392 pglRSLRTARHLEPGMVLTVEPGIYFIDHlldqaladpaqacffnqevlqrfrnfGGVRIEEDVVVTDSG 461
Cdd:cd01085 178 ---SPAPNNVPLKAGMILSNEPGYYKEGK--------------------------YGIRIENLVLVVEAE 218
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 192-467 2.93e-09

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 57.50  E-value: 2.93e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238 192 LEVLRYTNRISSEAHREVMKAVKVGMKEYEMESLFQHYCYSKGGmrhtsYTC----------ICCSgENAAVLHyghaGA 261
Cdd:cd01086   1 IEGMREAGRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEEHGA-----YPAplgyygfpksICTS-VNEVVCH----GI 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238 262 PNDRTIKDGDICLFDMGGEYYCFASDITCSFPAnGKFTDDQKAIYEAVLRSCRTVMSTMKPGVwwpdmhrladrihleel 341
Cdd:cd01086  71 PDDRVLKDGDIVNIDVGVELDGYHGDSARTFIV-GEVSEEAKKLVEVTEEALYKGIEAVKPGN----------------- 132

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238 342 tRIGLLSGSVDamlqvhlgAVFMPHGL-------GHFLGLDVHdvggypegvERIDEPGLRSLRTARHLEPGMVLTVEP- 413
Cdd:cd01086 133 -RIGDIGHAIE--------KYAEKNGYsvvrefgGHGIGRKFH---------EEPQIPNYGRPGTGPKLKPGMVFTIEPm 194

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238 414 ---GIYFIDHLLDQ---ALADPAQACFFnqevlqrfrnfggvriEEDVVVTDSGMELLTC 467
Cdd:cd01086 195 inlGTYEVVTLPDGwtvVTKDGSLSAQF----------------EHTVLITEDGPEILTL 238
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 187-466 1.05e-08

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 56.00  E-value: 1.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238  187 KTDMELEVLRYTNRISSEAHREVMKAVKVGMKEYEM-----ESLFQHYCYS--KGGMRHTSYTCICCsgeNAAVLHygha 259
Cdd:PRK12896  11 KSPRELEKMRKIGRIVATALKEMGKAVEPGMTTKELdriaeKRLEEHGAIPspEGYYGFPGSTCISV---NEEVAH---- 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238  260 GAPNDRTIKDGDICLFDMGGEYYCFASDiTC-SFPAnGKFTDDQKAIYEAVLRSCRTVMSTMKPGVwwpdmhRLADrihl 338
Cdd:PRK12896  84 GIPGPRVIKDGDLVNIDVSAYLDGYHGD-TGiTFAV-GPVSEEAEKLCRVAEEALWAGIKQVKAGR------PLND---- 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238  339 eeltrIGllsGSVDAMLQVHLGAV---FMPHGLGHFLGLDVHDVGGYPEGVERidepglrslrtaRHLEPGMVLTVEP-- 413
Cdd:PRK12896 152 -----IG---RAIEDFAKKNGYSVvrdLTGHGVGRSLHEEPSVILTYTDPLPN------------RLLRPGMTLAVEPfl 211

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 57528238  414 --GIYFIDHL--------LDQALAdpAQacffnqevlqrfrnfggvrIEEDVVVTDSGMELLT 466
Cdd:PRK12896 212 nlGAKDAETLddgwtvvtPDKSLS--AQ-------------------FEHTVVVTRDGPEILT 253
PRK12318 PRK12318
methionyl aminopeptidase;
185-466 3.97e-06

methionyl aminopeptidase;


Pssm-ID: 183434 [Multi-domain]  Cd Length: 291  Bit Score: 48.66  E-value: 3.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238  185 VFKTDMELEVLRYTNRISSEAHREVMKAVKVGMKEYEMESLFQHYcyskggmrHTSYTCIccsgenAAVLHYGHA----- 259
Cdd:PRK12318  42 IIKTPEQIEKIRKACQVTARILDALCEAAKEGVTTNELDELSREL--------HKEYNAI------PAPLNYGSPpfpkt 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238  260 -----------GAPNDRTIKDGDI------CLFDmggEYYCFASDITCSfpanGKFTDDQKAIYEAVLRSCRTVMSTMKP 322
Cdd:PRK12318 108 ictslnevichGIPNDIPLKNGDImnidvsCIVD---GYYGDCSRMVMI----GEVSEIKKKVCQASLECLNAAIAILKP 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238  323 GVwwpdmhrladrihleELTRIGLLSGSVDAMLQVHLGAVFMPHGLghflgldvhdvggypeGVERIDEPGLRSLRTARH 402
Cdd:PRK12318 181 GI---------------PLYEIGEVIENCADKYGFSVVDQFVGHGV----------------GIKFHENPYVPHHRNSSK 229

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 57528238  403 --LEPGMVLTVEPgiyFIDHLLDQALADPAqacffNQEVLQRFRNFGGVRIEEDVVVTDSGMELLT 466
Cdd:PRK12318 230 ipLAPGMIFTIEP---MINVGKKEGVIDPI-----NHWEARTCDNQPSAQWEHTILITETGYEILT 287
PRK14576 PRK14576
putative endopeptidase; Provisional
 171-474 8.15e-04

putative endopeptidase; Provisional


Pssm-ID: 173040 [Multi-domain]  Cd Length: 405  Bit Score: 41.92  E-value: 8.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238  171 VNNTILHPEIvecRVFKTDMELEVLRYTNRISSEAHREVMKAVKVGMKEYEMESLFQHYCYSKGGMRHTSYTCICCsGEN 250
Cdd:PRK14576 165 VDSTALFNEI---RMIKSPWEIEHLRKSAEITEYGIASAAKKIRVGCTAAELTAAFKAAVMSFPETNFSRFNLISV-GDN 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238  251 aavlhYGHAGAPNDRTIKDGDICLFDMGGEYYCFASDITCSFpANGKFTDDQKAIYEAVLRSCRTVMSTMKPGVWWPDMH 330
Cdd:PRK14576 241 -----FSPKIIADTTPAKVGDLIKFDCGIDVAGYGADLARTF-VLGEPDKLTQQIYDTIRTGHEHMLSMVAPGVKLKAVF 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57528238  331 rladrihleELTRIGLLSGSVDAMLQVHLGavfmpHGLGHFLGLdvhdvggypegveriDEPGLRSLRTARHLEPGMVLT 410
Cdd:PRK14576 315 ---------DSTMAVIKTSGLPHYNRGHLG-----HGDGVFLGL---------------EEVPFVSTQATETFCPGMVLS 365

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 57528238  411 VEPGIYFIdhlldqaladpaqacffnqevlqrfrNFGGVRIEEDVVVTDSGMELLTCVPRTVEE 474
Cdd:PRK14576 366 LETPYYGI--------------------------GVGSIMLEDMILITDSGFEFLSKLDRDLRR 403
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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