NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|56605672|ref|NP_001008278|]
View 

transducin beta-like protein 3 [Rattus norvegicus]

Protein Classification

WD40 and Utp13 domain-containing protein( domain architecture ID 10646028)

protein containing domains WD40, and Utp13

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
73-594 9.63e-65

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 221.71  E-value: 9.63e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672  73 DLSPDDEVLVTASRALLLAQWAWREGTVARLWkAIHTAPVASMAFDATSTLLATGGCDGAVRVWDIVQHYGTHHFRGSPG 152
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLL-LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 153 VVHLVAFHPDPTRLLlfSSAVDTSIRVWSLQDRSCLAVLTAHYSAVTSLSFSEDGHTMLSSGRDKicivwdlrsyetsrT 232
Cdd:COG2319  80 AVLSVAFSPDGRLLA--SASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG--------------T 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 233 VpvfesveasvllpeepalalgvknsglhfltagdqgilRVWEAASGQCVYTqpqmsglrqelthctlaraagllltvta 312
Cdd:COG2319 144 V--------------------------------------RLWDLATGKLLRT---------------------------- 157

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 313 dhnlllyearslqlqkqFAGYSEEVLDVRFlGPNDSHIIVASNSPCLKVFELQTLAC-QILHGHTDIVLALDVFRKGWLF 391
Cdd:COG2319 158 -----------------LTGHSGAVTSVAF-SPDGKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKLL 219

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 392 ASCAKDQSIRIWRMNKAgqvACVAQGSGHTHSVGTICCSRlKESFLVTGSQDCTVKLWplpealpskntasdgDLIPLQA 471
Cdd:COG2319 220 ASGSADGTVRLWDLATG---KLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLW---------------DLATGEL 280

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 472 QSTQRCHDKDINSLAVSPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWNVQFSPTDQVLATASADGTIKLWALQ 551
Cdd:COG2319 281 LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360

                       490       500       510       520
                ....*....|....*....|....*....|....*....|...
gi 56605672 552 DFSCLKTFEGHDASVLKVAFVSRGAQLLSSGSDGLLKLWTIKS 594
Cdd:COG2319 361 TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
Utp13 pfam08625
Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex ...
 654-786 6.30e-50

Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex that forms part of a stable particle subunit independent of the U3 small nucleolar ribonucleoprotein that is essential for the initial assembly steps of the 90S pre-ribosome. Pwp2 is capable of interacting directly with the 35 S pre-rRNA 5' end.


:

Pssm-ID: 462540  Cd Length: 139  Bit Score: 171.92  E-value: 6.30e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672   654 QQELDNLLHEKRYLRALGLAISLDRPHTVLTVIQAIRRDPEACEK------LEATVLRLRRDQKEALLRFCITWNTNSRH 727
Cdd:pfam08625   1 EQELQNLLRNKDYREAILLALTLNHPHRLLKLFKALLTSADDEGSitglkeLDEVIKTLSDEQLEKLLKYIRDWNTNAKT 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 56605672   728 CHEAQAVLGVLLRHEAPEELLAYDGVRGALEALLPYTERHFQRLSRTLQAATFLDFLWH 786
Cdd:pfam08625  81 SHVAQRVLNALLKSYPPEELLELPGLKEILEALIPYTERHFSRLDRLVQESYLLDYTLQ 139
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 594-633 1.09e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


:

Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 1.09e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 56605672    594 SNECVRTLDAHEDKVWGLHCSRLDDHAITGGSDSRIILWK 633
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
73-594 9.63e-65

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 221.71  E-value: 9.63e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672  73 DLSPDDEVLVTASRALLLAQWAWREGTVARLWkAIHTAPVASMAFDATSTLLATGGCDGAVRVWDIVQHYGTHHFRGSPG 152
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLL-LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 153 VVHLVAFHPDPTRLLlfSSAVDTSIRVWSLQDRSCLAVLTAHYSAVTSLSFSEDGHTMLSSGRDKicivwdlrsyetsrT 232
Cdd:COG2319  80 AVLSVAFSPDGRLLA--SASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG--------------T 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 233 VpvfesveasvllpeepalalgvknsglhfltagdqgilRVWEAASGQCVYTqpqmsglrqelthctlaraagllltvta 312
Cdd:COG2319 144 V--------------------------------------RLWDLATGKLLRT---------------------------- 157

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 313 dhnlllyearslqlqkqFAGYSEEVLDVRFlGPNDSHIIVASNSPCLKVFELQTLAC-QILHGHTDIVLALDVFRKGWLF 391
Cdd:COG2319 158 -----------------LTGHSGAVTSVAF-SPDGKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKLL 219

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 392 ASCAKDQSIRIWRMNKAgqvACVAQGSGHTHSVGTICCSRlKESFLVTGSQDCTVKLWplpealpskntasdgDLIPLQA 471
Cdd:COG2319 220 ASGSADGTVRLWDLATG---KLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLW---------------DLATGEL 280

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 472 QSTQRCHDKDINSLAVSPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWNVQFSPTDQVLATASADGTIKLWALQ 551
Cdd:COG2319 281 LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360

                       490       500       510       520
                ....*....|....*....|....*....|....*....|...
gi 56605672 552 DFSCLKTFEGHDASVLKVAFVSRGAQLLSSGSDGLLKLWTIKS 594
Cdd:COG2319 361 TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 328-633 1.74e-59

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 203.72  E-value: 1.74e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 328 KQFAGYSEEVLDVRFLgPNDSHIIVASNSPCLKVFELQTLACQI-LHGHTDIVLALDVFRKGWLFASCAKDQSIRIWRMN 406
Cdd:cd00200   3 RTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRtLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 407 KAGQVACVAqgsGHTHSVGTICCSRlKESFLVTGSQDCTVKLWplpealpskntasdgDLIPLQAQSTQRCHDKDINSLA 486
Cdd:cd00200  82 TGECVRTLT---GHTSYVSSVAFSP-DGRILSSSSRDKTIKVW---------------DVETGKCLTTLRGHTDWVNSVA 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 487 VSPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWNVQFSPTDQVLATASADGTIKLWALQDFSCLKTFEGHDASV 566
Cdd:cd00200 143 FSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGV 222

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56605672 567 LKVAFvSRGAQLLSSGS-DGLLKLWTIKSNECVRTLDAHEDKVWGLHCSRLDDHAITGGSDSRIILWK 633
Cdd:cd00200 223 NSVAF-SPDGYLLASGSeDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
Utp13 pfam08625
Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex ...
 654-786 6.30e-50

Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex that forms part of a stable particle subunit independent of the U3 small nucleolar ribonucleoprotein that is essential for the initial assembly steps of the 90S pre-ribosome. Pwp2 is capable of interacting directly with the 35 S pre-rRNA 5' end.


Pssm-ID: 462540  Cd Length: 139  Bit Score: 171.92  E-value: 6.30e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672   654 QQELDNLLHEKRYLRALGLAISLDRPHTVLTVIQAIRRDPEACEK------LEATVLRLRRDQKEALLRFCITWNTNSRH 727
Cdd:pfam08625   1 EQELQNLLRNKDYREAILLALTLNHPHRLLKLFKALLTSADDEGSitglkeLDEVIKTLSDEQLEKLLKYIRDWNTNAKT 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 56605672   728 CHEAQAVLGVLLRHEAPEELLAYDGVRGALEALLPYTERHFQRLSRTLQAATFLDFLWH 786
Cdd:pfam08625  81 SHVAQRVLNALLKSYPPEELLELPGLKEILEALIPYTERHFSRLDRLVQESYLLDYTLQ 139
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 376-592 3.80e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.57  E-value: 3.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672  376 TDIVLALDVFRKGWLFASCAKDQSIRIWRMN---KAGQ-----VACVAQGSghthSVGTICCSRLKESFLVTGSQDCTVK 447
Cdd:PLN00181 483 SNLVCAIGFDRDGEFFATAGVNKKIKIFECEsiiKDGRdihypVVELASRS----KLSGICWNSYIKSQVASSNFEGVVQ 558

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672  448 LWplpealpskntasdgDLIPLQAQSTQRCHDKDINSLAVSPND-KLLATGSQDRTAKLWALPQCQLLGVFSGhRRGLWN 526
Cdd:PLN00181 559 VW---------------DVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICC 622

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56605672  527 VQF-SPTDQVLATASADGTIKLWALQDFSC-LKTFEGHDASVLKVAFVSrGAQLLSSGSDGLLKLWTI 592
Cdd:PLN00181 623 VQFpSESGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVD-SSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 512-548 1.92e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.92e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 56605672    512 QLLGVFSGHRRGLWNVQFSPTDQVLATASADGTIKLW 548
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
512-548 5.14e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 5.14e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 56605672   512 QLLGVFSGHRRGLWNVQFSPTDQVLATASADGTIKLW 548
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 594-633 1.09e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 1.09e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 56605672    594 SNECVRTLDAHEDKVWGLHCSRLDDHAITGGSDSRIILWK 633
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
595-632 5.87e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 5.87e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 56605672   595 NECVRTLDAHEDKVWGLHCSRLDDHAITGGSDSRIILW 632
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
73-594 9.63e-65

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 221.71  E-value: 9.63e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672  73 DLSPDDEVLVTASRALLLAQWAWREGTVARLWkAIHTAPVASMAFDATSTLLATGGCDGAVRVWDIVQHYGTHHFRGSPG 152
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLL-LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 153 VVHLVAFHPDPTRLLlfSSAVDTSIRVWSLQDRSCLAVLTAHYSAVTSLSFSEDGHTMLSSGRDKicivwdlrsyetsrT 232
Cdd:COG2319  80 AVLSVAFSPDGRLLA--SASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG--------------T 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 233 VpvfesveasvllpeepalalgvknsglhfltagdqgilRVWEAASGQCVYTqpqmsglrqelthctlaraagllltvta 312
Cdd:COG2319 144 V--------------------------------------RLWDLATGKLLRT---------------------------- 157

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 313 dhnlllyearslqlqkqFAGYSEEVLDVRFlGPNDSHIIVASNSPCLKVFELQTLAC-QILHGHTDIVLALDVFRKGWLF 391
Cdd:COG2319 158 -----------------LTGHSGAVTSVAF-SPDGKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKLL 219

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 392 ASCAKDQSIRIWRMNKAgqvACVAQGSGHTHSVGTICCSRlKESFLVTGSQDCTVKLWplpealpskntasdgDLIPLQA 471
Cdd:COG2319 220 ASGSADGTVRLWDLATG---KLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLW---------------DLATGEL 280

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 472 QSTQRCHDKDINSLAVSPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWNVQFSPTDQVLATASADGTIKLWALQ 551
Cdd:COG2319 281 LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360

                       490       500       510       520
                ....*....|....*....|....*....|....*....|...
gi 56605672 552 DFSCLKTFEGHDASVLKVAFVSRGAQLLSSGSDGLLKLWTIKS 594
Cdd:COG2319 361 TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 328-633 1.74e-59

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 203.72  E-value: 1.74e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 328 KQFAGYSEEVLDVRFLgPNDSHIIVASNSPCLKVFELQTLACQI-LHGHTDIVLALDVFRKGWLFASCAKDQSIRIWRMN 406
Cdd:cd00200   3 RTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRtLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 407 KAGQVACVAqgsGHTHSVGTICCSRlKESFLVTGSQDCTVKLWplpealpskntasdgDLIPLQAQSTQRCHDKDINSLA 486
Cdd:cd00200  82 TGECVRTLT---GHTSYVSSVAFSP-DGRILSSSSRDKTIKVW---------------DVETGKCLTTLRGHTDWVNSVA 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 487 VSPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWNVQFSPTDQVLATASADGTIKLWALQDFSCLKTFEGHDASV 566
Cdd:cd00200 143 FSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGV 222

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56605672 567 LKVAFvSRGAQLLSSGS-DGLLKLWTIKSNECVRTLDAHEDKVWGLHCSRLDDHAITGGSDSRIILWK 633
Cdd:cd00200 223 NSVAF-SPDGYLLASGSeDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
263-632 4.96e-59

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 206.30  E-value: 4.96e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 263 LTAGDQGILRVWEAASGQCVYTQPqmsGLRQELTHCTLARAAGLLLTVTADHNLLLYEARSLQLQKQFAGYSEEVLDVRF 342
Cdd:COG2319  10 AAASADLALALLAAALGALLLLLL---GLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAF 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 343 LgPNDSHIIVASNSPCLKVFELQTLAC-QILHGHTDIVLALDVFRKGWLFASCAKDQSIRIWRMNKAgqvACVAQGSGHT 421
Cdd:COG2319  87 S-PDGRLLASASADGTVRLWDLATGLLlRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG---KLLRTLTGHS 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 422 HSVGTICCSRlKESFLVTGSQDCTVKLWplpealpskntasdgDLIPLQAQSTQRCHDKDINSLAVSPNDKLLATGSQDR 501
Cdd:COG2319 163 GAVTSVAFSP-DGKLLASGSDDGTVRLW---------------DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADG 226

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 502 TAKLWALPQCQLLGVFSGHRRGLWNVQFSPTDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGAQLLSS 581
Cdd:COG2319 227 TVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASG 306

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|.
gi 56605672 582 GSDGLLKLWTIKSNECVRTLDAHEDKVWGLHCSRLDDHAITGGSDSRIILW 632
Cdd:COG2319 307 SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 144-449 7.29e-53

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 185.23  E-value: 7.29e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 144 THHFRGSPGVVHLVAFHPDPTrlLLFSSAVDTSIRVWSLQDRSCLAVLTAHYSAVTSLSFSEDGHTMLSSGRDKICIVWD 223
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGK--LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 224 LRSYETSRTvpvFESVEASVllpeepaLALGVKNSGLHFLTAGDQGILRVWEAASGQCVYTqpqMSGLRQELTHCTLARA 303
Cdd:cd00200  80 LETGECVRT---LTGHTSYV-------SSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTT---LRGHTDWVNSVAFSPD 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 304 AGLLLTVTADHNLLLYEARSLQLQKQFAGYSEEVLDVRFLgPNDSHIIVASNSPCLKVFELQTLAC-QILHGHTDIVLAL 382
Cdd:cd00200 147 GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFS-PDGEKLLSSSSDGTIKLWDLSTGKClGTLRGHENGVNSV 225

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 56605672 383 DVFRKGWLFASCAKDQSIRIWRMNKAgqvACVAQGSGHTHSVGTICCSRLKeSFLVTGSQDCTVKLW 449
Cdd:cd00200 226 AFSPDGYLLASGSEDGTIRVWDLRTG---ECVQTLSGHTNSVTSLAWSPDG-KRLASGSADGTIRIW 288
Utp13 pfam08625
Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex ...
 654-786 6.30e-50

Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex that forms part of a stable particle subunit independent of the U3 small nucleolar ribonucleoprotein that is essential for the initial assembly steps of the 90S pre-ribosome. Pwp2 is capable of interacting directly with the 35 S pre-rRNA 5' end.


Pssm-ID: 462540  Cd Length: 139  Bit Score: 171.92  E-value: 6.30e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672   654 QQELDNLLHEKRYLRALGLAISLDRPHTVLTVIQAIRRDPEACEK------LEATVLRLRRDQKEALLRFCITWNTNSRH 727
Cdd:pfam08625   1 EQELQNLLRNKDYREAILLALTLNHPHRLLKLFKALLTSADDEGSitglkeLDEVIKTLSDEQLEKLLKYIRDWNTNAKT 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 56605672   728 CHEAQAVLGVLLRHEAPEELLAYDGVRGALEALLPYTERHFQRLSRTLQAATFLDFLWH 786
Cdd:pfam08625  81 SHVAQRVLNALLKSYPPEELLELPGLKEILEALIPYTERHFSRLDRLVQESYLLDYTLQ 139
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 47-275 5.23e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.85  E-value: 5.23e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672  47 VNILDVASGDLIRSLEQeDQEDITAFDLSPDDEVLVTASRALLLAQWAWREGTVARLWKAiHTAPVASMAFDATSTLLAT 126
Cdd:cd00200  75 IRLWDLETGECVRTLTG-HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVAS 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 127 GGCDGAVRVWDIVQHYGTHHFRGSPGVVHLVAFHPDPTRLLlfSSAVDTSIRVWSLQDRSCLAVLTAHYSAVTSLSFSED 206
Cdd:cd00200 153 SSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLL--SSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD 230

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 56605672 207 GHTMLSSGRDKICIVWDLRSYETSRTVPvfesveasvlLPEEPALALGVKNSGLHFLTAGDQGILRVWE 275
Cdd:cd00200 231 GYLLASGSEDGTIRVWDLRTGECVQTLS----------GHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 513-632 6.99e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.13  E-value: 6.99e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 513 LLGVFSGHRRGLWNVQFSPTDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGAQLLSSGSDGLLKLWTI 592
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 56605672 593 KSNECVRTLDAHEDKVWGLHCSRLDDHAITGGSDSRIILW 632
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVW 120
WD40 COG2319
WD40 repeat [General function prediction only];
486-632 1.38e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.73  E-value: 1.38e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672 486 AVSPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWNVQFSPTDQVLATASADGTIKLWALQDFSCLKTFEGHDAS 565
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 56605672 566 VLKVAFVSRGAQLLSSGSDGLLKLWTIKSNECVRTLDAHEDKVWGLHCSRLDDHAITGGSDSRIILW 632
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW 147
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 376-592 3.80e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.57  E-value: 3.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672  376 TDIVLALDVFRKGWLFASCAKDQSIRIWRMN---KAGQ-----VACVAQGSghthSVGTICCSRLKESFLVTGSQDCTVK 447
Cdd:PLN00181 483 SNLVCAIGFDRDGEFFATAGVNKKIKIFECEsiiKDGRdihypVVELASRS----KLSGICWNSYIKSQVASSNFEGVVQ 558

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672  448 LWplpealpskntasdgDLIPLQAQSTQRCHDKDINSLAVSPND-KLLATGSQDRTAKLWALPQCQLLGVFSGhRRGLWN 526
Cdd:PLN00181 559 VW---------------DVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICC 622

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 56605672  527 VQF-SPTDQVLATASADGTIKLWALQDFSC-LKTFEGHDASVLKVAFVSrGAQLLSSGSDGLLKLWTI 592
Cdd:PLN00181 623 VQFpSESGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVD-SSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 512-548 1.92e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.92e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 56605672    512 QLLGVFSGHRRGLWNVQFSPTDQVLATASADGTIKLW 548
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 184-223 4.50e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 4.50e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 56605672    184 DRSCLAVLTAHYSAVTSLSFSEDGHTMLSSGRDKICIVWD 223
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
512-548 5.14e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 5.14e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 56605672   512 QLLGVFSGHRRGLWNVQFSPTDQVLATASADGTIKLW 548
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
185-223 5.40e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 5.40e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 56605672   185 RSCLAVLTAHYSAVTSLSFSEDGHTMLSSGRDKICIVWD 223
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 473-506 1.31e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 1.31e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 56605672    473 STQRCHDKDINSLAVSPNDKLLATGSQDRTAKLW 506
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PTZ00421 PTZ00421
coronin; Provisional
 111-226 1.55e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 51.43  E-value: 1.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672  111 PVASMAFDA-TSTLLATGGCDGAVRVWDI-----VQHYGTH--HFRGSPGVVHLVAFHPDPTRLLLfSSAVDTSIRVWSL 182
Cdd:PTZ00421  77 PIIDVAFNPfDPQKLFTASEDGTIMGWGIpeeglTQNISDPivHLQGHTKKVGIVSFHPSAMNVLA-SAGADMVVNVWDV 155

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 56605672  183 QDRSCLAVLTAHYSAVTSLSFSEDGHTMLSSGRDKICIVWDLRS 226
Cdd:PTZ00421 156 ERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRD 199
WD40 pfam00400
WD domain, G-beta repeat;
472-506 2.13e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 2.13e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 56605672   472 QSTQRCHDKDINSLAVSPNDKLLATGSQDRTAKLW 506
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 552-590 3.46e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 3.46e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 56605672    552 DFSCLKTFEGHDASVLKVAFVSRGAQLLSSGSDGLLKLW 590
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 108-137 1.54e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.54e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 56605672    108 HTAPVASMAFDATSTLLATGGCDGAVRVWD 137
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
553-590 1.72e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.72e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 56605672   553 FSCLKTFEGHDASVLKVAFVSRGAQLLSSGSDGLLKLW 590
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
108-137 2.20e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 2.20e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 56605672   108 HTAPVASMAFDATSTLLATGGCDGAVRVWD 137
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 119-224 5.61e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.62  E-value: 5.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672  119 ATSTLLATGGCDGAVRVWDIVQHYGTHHFRGSPGVVhLVAFHPDPTRLLLFSSAvDTSIRVWSLQD-RSCLAVLTAHYSA 197
Cdd:PLN00181 586 ADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANIC-CVQFPSESGRSLAFGSA-DHKVYYYDLRNpKLPLCTMIGHSKT 663

                         90       100
                 ....*....|....*....|....*..
gi 56605672  198 VTSLSFSeDGHTMLSSGRDKICIVWDL 224
Cdd:PLN00181 664 VSYVRFV-DSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 369-403 6.59e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 6.59e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 56605672    369 CQILHGHTDIVLALDVFRKGWLFASCAKDQSIRIW 403
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 594-633 1.09e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 1.09e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 56605672    594 SNECVRTLDAHEDKVWGLHCSRLDDHAITGGSDSRIILWK 633
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 527-626 5.66e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.54  E-value: 5.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672  527 VQFSPTDQVLATASADGTIKLwalqdFSCLKTF-EGHDASVLKVAFVSRG------------AQLLSSGSDGLLKLWTIK 593
Cdd:PLN00181 489 IGFDRDGEFFATAGVNKKIKI-----FECESIIkDGRDIHYPVVELASRSklsgicwnsyikSQVASSNFEGVVQVWDVA 563

                         90       100       110
                 ....*....|....*....|....*....|...
gi 56605672  594 SNECVRTLDAHEDKVWGLHCSRLDDHAITGGSD 626
Cdd:PLN00181 564 RSQLVTEMKEHEKRVWSIDYSSADPTLLASGSD 596
WD40 pfam00400
WD domain, G-beta repeat;
595-632 5.87e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 5.87e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 56605672   595 NECVRTLDAHEDKVWGLHCSRLDDHAITGGSDSRIILW 632
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
413-449 1.10e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.10e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 56605672   413 CVAQGSGHTHSVGTICCSRlKESFLVTGSQDCTVKLW 449
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 413-449 1.30e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.30e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 56605672    413 CVAQGSGHTHSVGTICCSRlKESFLVTGSQDCTVKLW 449
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
PTZ00421 PTZ00421
coronin; Provisional
 481-632 1.79e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.80  E-value: 1.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672  481 DINSLAVSP-NDKLLATGSQDRTAKLWALPQCQLLGVFS-------GHRRGLWNVQFSPT-DQVLATASADGTIKLWALQ 551
Cdd:PTZ00421  77 PIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQNISdpivhlqGHTKKVGIVSFHPSaMNVLASAGADMVVNVWDVE 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56605672  552 DFSCLKTFEGHDASVLKVAFVSRGAQLLSSGSDGLLKLWTIKSNECVRTLDAHEDK-----VWglhCSRLDDHAITGGSD 626
Cdd:PTZ00421 157 RGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAksqrcLW---AKRKDLIITLGCSK 233


                 ....*....
gi 56605672  627 S---RIILW 632
Cdd:PTZ00421 234 SqqrQIMLW 242
WD40 pfam00400
WD domain, G-beta repeat;
370-403 7.24e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 7.24e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 56605672   370 QILHGHTDIVLALDVFRKGWLFASCAKDQSIRIW 403
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH