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Conserved domains on  [gi|109254776|ref|NP_001007121|]
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homeobox and leucine zipper encoding a [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homez pfam11569
Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and ...
 588-644 2.96e-26

Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and an acidic domain and belongs to the superfamily of homeobox-containing proteins. The presence of leucine zippers suggests that Homez can function as a homo or heterodimer in the nucleus. It is thought that the first leucine zipper and homeodomain 1 (HD1)of Homez is responsible for dimerization and HD2 has a specific DNA-binding activity. Homez is also thought to function as a transcriptional repressor due to the acidic region in its C-terminal domain. Homez is involved in a complex regulatory network.


:

Pssm-ID: 463297  Cd Length: 57  Bit Score: 101.61  E-value: 2.96e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 109254776  588 TQKSAADSVDVSPLELYFRQTGPLQEKDLDNLCRKSKMSYQQVRDWFASKDSTTLDT 644
Cdd:pfam11569   1 PLPAPPDSPDIRPLEKYWAATGQLQEKDLDKLCQKSKMSYQQVRDWFASRLSKPAEV 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 485-537 2.40e-06

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


:

Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 44.93  E-value: 2.40e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 109254776   485 RPRKTKEQLTILKEYFQHCPWPKSGEYTEVVELTSLPRADVIQWFGDTRYAVK 537
Cdd:smart00389   5 RTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 95-144 1.70e-05

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 42.62  E-value: 1.70e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 109254776  95 DSIPELVQAFNIFPYPTSQEVSTLARVCTLPLDKVKVWFMVQRIKYGISW 144
Cdd:cd00086   10 EQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 191-256 3.85e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 3.85e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 109254776  191 PQMPRKRPKTESTEPAK--LSPAPSRFRSSLPPPQDsyyyrqPVEIPETPQAATPPTATESPVVSEQP 256
Cdd:PHA03247 2868 SRSPAAKPAAPARPPVRrlARPAVSRSTESFALPPD------QPERPPQPQAPPPPQPQPQPPPPPQP 2929
 
Name Accession Description Interval E-value
Homez pfam11569
Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and ...
 588-644 2.96e-26

Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and an acidic domain and belongs to the superfamily of homeobox-containing proteins. The presence of leucine zippers suggests that Homez can function as a homo or heterodimer in the nucleus. It is thought that the first leucine zipper and homeodomain 1 (HD1)of Homez is responsible for dimerization and HD2 has a specific DNA-binding activity. Homez is also thought to function as a transcriptional repressor due to the acidic region in its C-terminal domain. Homez is involved in a complex regulatory network.


Pssm-ID: 463297  Cd Length: 57  Bit Score: 101.61  E-value: 2.96e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 109254776  588 TQKSAADSVDVSPLELYFRQTGPLQEKDLDNLCRKSKMSYQQVRDWFASKDSTTLDT 644
Cdd:pfam11569   1 PLPAPPDSPDIRPLEKYWAATGQLQEKDLDKLCQKSKMSYQQVRDWFASRLSKPAEV 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 485-537 2.40e-06

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 44.93  E-value: 2.40e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 109254776   485 RPRKTKEQLTILKEYFQHCPWPKSGEYTEVVELTSLPRADVIQWFGDTRYAVK 537
Cdd:smart00389   5 RTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 485-540 3.34e-06

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 44.54  E-value: 3.34e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 109254776 485 RPRKTKEQLTILKEYFQHCPWPKSGEYTEVVELTSLPRADVIQWFGDTRYAVKNGH 540
Cdd:cd00086    4 RTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 95-144 1.70e-05

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 42.62  E-value: 1.70e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 109254776  95 DSIPELVQAFNIFPYPTSQEVSTLARVCTLPLDKVKVWFMVQRIKYGISW 144
Cdd:cd00086   10 EQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 97-140 4.09e-04

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 38.77  E-value: 4.09e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 109254776    97 IPELVQAFNIFPYPTSQEVSTLARVCTLPLDKVKVWFMVQRIKY 140
Cdd:smart00389  13 LEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56
PHA03247 PHA03247
large tegument protein UL36; Provisional
 191-256 3.85e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 3.85e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 109254776  191 PQMPRKRPKTESTEPAK--LSPAPSRFRSSLPPPQDsyyyrqPVEIPETPQAATPPTATESPVVSEQP 256
Cdd:PHA03247 2868 SRSPAAKPAAPARPPVRrlARPAVSRSTESFALPPD------QPERPPQPQAPPPPQPQPQPPPPPQP 2929
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
462-537 4.74e-03

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 38.19  E-value: 4.74e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 109254776 462 NSLNTSLNLPDNSSPSsvltVAGRPRKTKEQLTILKEYFQHCPWPKSGEYTEVVELTSLPRADVIQWFGDTRYAVK 537
Cdd:COG5576   36 DSEMKLERKQDGSSPP----KSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEK 107
Homeodomain pfam00046
Homeodomain;
88-140 5.93e-03

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 35.55  E-value: 5.93e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 109254776   88 SDQTRELDSipelvqAFNIFPYPTSQEVSTLARVCTLPLDKVKVWFMVQRIKY 140
Cdd:pfam00046   9 PEQLEELEK------EFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKW 55
 
Name Accession Description Interval E-value
Homez pfam11569
Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and ...
 588-644 2.96e-26

Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and an acidic domain and belongs to the superfamily of homeobox-containing proteins. The presence of leucine zippers suggests that Homez can function as a homo or heterodimer in the nucleus. It is thought that the first leucine zipper and homeodomain 1 (HD1)of Homez is responsible for dimerization and HD2 has a specific DNA-binding activity. Homez is also thought to function as a transcriptional repressor due to the acidic region in its C-terminal domain. Homez is involved in a complex regulatory network.


Pssm-ID: 463297  Cd Length: 57  Bit Score: 101.61  E-value: 2.96e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 109254776  588 TQKSAADSVDVSPLELYFRQTGPLQEKDLDNLCRKSKMSYQQVRDWFASKDSTTLDT 644
Cdd:pfam11569   1 PLPAPPDSPDIRPLEKYWAATGQLQEKDLDKLCQKSKMSYQQVRDWFASRLSKPAEV 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 485-537 2.40e-06

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 44.93  E-value: 2.40e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 109254776   485 RPRKTKEQLTILKEYFQHCPWPKSGEYTEVVELTSLPRADVIQWFGDTRYAVK 537
Cdd:smart00389   5 RTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 485-540 3.34e-06

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 44.54  E-value: 3.34e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 109254776 485 RPRKTKEQLTILKEYFQHCPWPKSGEYTEVVELTSLPRADVIQWFGDTRYAVKNGH 540
Cdd:cd00086    4 RTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 95-144 1.70e-05

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 42.62  E-value: 1.70e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 109254776  95 DSIPELVQAFNIFPYPTSQEVSTLARVCTLPLDKVKVWFMVQRIKYGISW 144
Cdd:cd00086   10 EQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 97-140 4.09e-04

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 38.77  E-value: 4.09e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 109254776    97 IPELVQAFNIFPYPTSQEVSTLARVCTLPLDKVKVWFMVQRIKY 140
Cdd:smart00389  13 LEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56
PHA03247 PHA03247
large tegument protein UL36; Provisional
 191-256 3.85e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 3.85e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 109254776  191 PQMPRKRPKTESTEPAK--LSPAPSRFRSSLPPPQDsyyyrqPVEIPETPQAATPPTATESPVVSEQP 256
Cdd:PHA03247 2868 SRSPAAKPAAPARPPVRrlARPAVSRSTESFALPPD------QPERPPQPQAPPPPQPQPQPPPPPQP 2929
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
462-537 4.74e-03

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 38.19  E-value: 4.74e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 109254776 462 NSLNTSLNLPDNSSPSsvltVAGRPRKTKEQLTILKEYFQHCPWPKSGEYTEVVELTSLPRADVIQWFGDTRYAVK 537
Cdd:COG5576   36 DSEMKLERKQDGSSPP----KSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEK 107
Homeodomain pfam00046
Homeodomain;
88-140 5.93e-03

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 35.55  E-value: 5.93e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 109254776   88 SDQTRELDSipelvqAFNIFPYPTSQEVSTLARVCTLPLDKVKVWFMVQRIKY 140
Cdd:pfam00046   9 PEQLEELEK------EFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKW 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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