|
Name |
Accession |
Description |
Interval |
E-value |
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
370-611 |
1.23e-31 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 125.84 E-value: 1.23e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 370 LLSIGADFKIKEKTGRNFLHFVILQPKGLKNLPETVLQSTAVKEMLSDEDVEGCTPLHYACKLGIHDSVKNMLGLNICLG 449
Cdd:COG0666 2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 450 QKSREKKSALHFAAEYGRINTCHRLLETLTDskmLNDWDEKGLTPLHLASRAGHAQVVDLLLRKGA-LFQSDYKGWTCLH 528
Cdd:COG0666 82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGAD---VNARDKDGETPLHLAAYNGNLEIVKLLLEAGAdVNAQDNDGNTPLH 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 529 HAAAEGYTQTMKILLAANVKLlDEKNEDGNTALHIAAQAGHVSAVLLLLDRGAEI-ALNDADNSFLHEAVRNERREVVNA 607
Cdd:COG0666 159 LAAANGNLEIVKLLLEAGADV-NARDNDGETPLHLAAENGHLEIVKLLLEAGADVnAKDNDGKTALDLAAENGNLEIVKL 237
|
....
gi 55742489 608 TIEH 611
Cdd:COG0666 238 LLEA 241
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
111-394 |
1.55e-30 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 122.76 E-value: 1.55e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 111 AVLLDLGADPNILNNALMGPLHLAVTKQYNHLAEVLLSCDKTNSNLEGDLGNTPVMLACSNNNCQALQILIKRGAKMCIQ 190
Cdd:COG0666 4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 191 NKLGHYPIHTVAFAGAKEAMEMVLKIGeelgvsstLHINYLDKSKSTPLHLAVRGGNIEVIKLCILKGAKVEQHQSGKCT 270
Cdd:COG0666 84 DDGGNTLLHAAARNGDLEIVKLLLEAG--------ADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 271 ALHFACSQGSLEAVKIMLSSYnrteDIVNIRDGANRTPLHRATLFDHVELAEYLISkpntlsldliclgKGAEIDSIDCK 350
Cdd:COG0666 156 PLHLAAANGNLEIVKLLLEAG----ADVNARDNDGETPLHLAAENGHLEIVKLLLE-------------AGADVNAKDND 218
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 55742489 351 GLSPLLLASSCSAWKTVAYLLSIGADFKIKEKTGRNFLHFVILQ 394
Cdd:COG0666 219 GKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAA 262
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
495-587 |
6.53e-18 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 79.77 E-value: 6.53e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 495 LHLASRAGHAQVVDLLLRKGA-LFQSDYKGWTCLHHAAAEGYTQTMKILLAANVKlldEKNEDGNTALHIAAQAGHVSAV 573
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGAdANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV---NLKDNGRTALHYAARSGHLEIV 77
|
90
....*....|....
gi 55742489 574 LLLLDRGAEIALND 587
Cdd:pfam12796 78 KLLLEKGADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
239-327 |
2.24e-14 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 69.76 E-value: 2.24e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 239 LHLAVRGGNIEVIKLCILKGAKVEQHQSGKCTALHFACSQGSLEAVKIMLSSYNrtediVNIRDGaNRTPLHRATLFDHV 318
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD-----VNLKDN-GRTALHYAARSGHL 74
|
....*....
gi 55742489 319 ELAEYLISK 327
Cdd:pfam12796 75 EIVKLLLEK 83
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
228-515 |
8.55e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 74.70 E-value: 8.55e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 228 INYLDKSKSTPLHLAVRGGNIEVIKLCILKGAKVEQHQSGKCTALHFAcsqgsleavkimlssynrTEDIVNIRDGanrt 307
Cdd:PHA03100 28 NDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYL------------------SNIKYNLTDV---- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 308 plhratlfdhVELAEYLISkpntlsldliclgKGAEIDSIDCKGLSPLLLASSCSA--WKTVAYLLSIGADFKIKEKTGR 385
Cdd:PHA03100 86 ----------KEIVKLLLE-------------YGANVNAPDNNGITPLLYAISKKSnsYSIVEYLLDNGANVNIKNSDGE 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 386 NFLHFVILQPKGLKNLPETVLQSTAvkemlsdeDVEGCTPLHYACKLGIHDSVKNMLGlniclgqksrekKSALHFAAEY 465
Cdd:PHA03100 143 NLLHLYLESNKIDLKILKLLIDKGV--------DINAKNRVNYLLSYGVPINIKDVYG------------FTPLHYAVYN 202
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 55742489 466 GRINTCHRLLETLTDskmLNDWDEKGLTPLHLASRAGHAQVVDLLLRKGA 515
Cdd:PHA03100 203 NNPEFVKYLLDLGAN---PNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
|
|
| Ion_trans |
pfam00520 |
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ... |
759-977 |
8.83e-14 |
|
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 72.30 E-value: 8.83e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 759 TSVIMVPV--SFSEQQYLISVCIIMVIVMNVYSICKEVVQLAQQRV--NYFTDFSNPADWSAAISALVFVVPmccsveaT 834
Cdd:pfam00520 14 LNTIFLALetYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkkRYFRSPWNILDFVVVLPSLISLVL-------S 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 835 WQWEAGAYAILTSW--IGFLLYFQRFERIGIYVVMFNGIVRTLVCIMVLFVFLLLAFGLAFYAL-----------MLHRP 901
Cdd:pfam00520 87 SVGSLSGLRVLRLLrlLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLfggklktwenpDNGRT 166
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 55742489 902 EFSSISLALAQTFVMTVGElNYQSTFLNSYEEGHmafPAITYFVFVFFVLLMPILLMNLMIGLAVGDIAEVQRNAE 977
Cdd:pfam00520 167 NFDNFPNAFLWLFQTMTTE-GWGDIMYDTIDGKG---EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
|
|
| TRPV |
cd21882 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ... |
456-1002 |
5.28e-13 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).
Pssm-ID: 411975 [Multi-domain] Cd Length: 600 Bit Score: 72.99 E-value: 5.28e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 456 KSALHFAAEY---GRINTCHRLLETLTDSKMLNDW------DE--KGLTPLHLASRAGHAQVVDLLLRKGA--------- 515
Cdd:cd21882 27 KTCLHKAALNlndGVNEAIMLLLEAAPDSGNPKELvnapctDEfyQGQTALHIAIENRNLNLVRLLVENGAdvsaratgr 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 516 LFQSD-----YKGWTCLHHAAAEGYTQTMKILL--AANVKLLDEKNEDGNTALHIAAqaghvsavlllldrgaEIALNDA 588
Cdd:cd21882 107 FFRKSpgnlfYFGELPLSLAACTNQEEIVRLLLenGAQPAALEAQDSLGNTVLHALV----------------LQADNTP 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 589 DNSFLHEAVRNE-----RREVVNATIEHERCDESMTSFKaksrcvvLDIIEFLPESFQHLLDQCITESDHdansqdyHIM 663
Cdd:cd21882 171 ENSAFVCQMYNLllsygAHLDPTQQLEEIPNHQGLTPLK-------LAAVEGKIVMFQHILQREFSGPYQ-------PLS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 664 YNF-QWLQAPIQLKKYAKTD----KTKAFQPLAALNAMVRYNRLELLIHPLsRKYLEMKWTAYGSKVHFLNLAIYLLGLL 738
Cdd:cd21882 237 RKFtEWTYGPVTSSLYDLSEidswEKNSVLELIAFSKKREARHQMLVQEPL-NELLQEKWDRYGRPYFCFNFACYLLYMI 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 739 PLTYLILNlRPSQDfsKGNGTSVIMVPvsfseQQYLISVCIIMVIVMNVYSICKEVVQLAQQRVNYFTDF-SNPADWSAA 817
Cdd:cd21882 316 IFTVCAYY-RPLKD--RPANQEAKATF-----GDSIRLVGEILTVLGGVYILLGEIPYFFRRRLSRWFGFlDSYFEILFI 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 818 ISALVFVVPMCCS-VEATWQWEAGAYAILTSWIGFLLYFQRFERIGIYVVMFNG-IVRTLVCIMVLFVFLLLAFGLAFYA 895
Cdd:cd21882 388 TQALLVLLSMVLRfMETEGYVVPLVFSLVLGWCNVLYYTRGFQMLGIYTVMIQKmILRDLMRFCWVYLVFLFGFASAFVI 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 896 LML-----HRPEFSSISLALAQTFVMTVG----ELNYQstflnsyeeghMAFPAITYFVFVFFVLLMPILLMNLMIGL-- 964
Cdd:cd21882 468 LFQtedpnKLGEFRDYPDALLELFKFTIGmgdlPFNEN-----------VDFPFVYLILLLAYVILTYLLLLNMLIALmg 536
|
570 580 590 600
....*....|....*....|....*....|....*....|
gi 55742489 965 -AVGDIAEVQRNA-ELKRIAMQIDlhtaLEEKLPYWFLKR 1002
Cdd:cd21882 537 eTVNRVAQESDEIwKLQKAITTLM----LERKYPRCLRKR 572
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
70-388 |
9.11e-13 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 71.92 E-value: 9.11e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 70 GNLDIIRLIVSIVGpEVLNVQDEQGRTPLHWAVEQDQQQSCAVLLDLGADPNILNNALMGPLHLAVTKQYNHLAEVLLSC 149
Cdd:PHA02874 12 GDIEAIEKIIKNKG-NCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDN 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 150 DKTNSNLegdlgntPVmlACSNNncQALQILIKRGAKMCIQNKLGHYPIHTVAFAGAKEAMEMVLKIGEElgvsstlhIN 229
Cdd:PHA02874 91 GVDTSIL-------PI--PCIEK--DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGAD--------VN 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 230 YLDKSKSTPLHLAVRGGNIEVIKLCILKGAKVEQHQSGKCTALHFACSQGSLEAVKIMLSSYNrtedivNIRDGANR--T 307
Cdd:PHA02874 152 IEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGN------HIMNKCKNgfT 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 308 PLHRATLFDHvELAEYLISKpntlsldliclgkgAEIDSIDCKGLSPL--LLASSCSAwKTVAYLLSIGADFKIKEKTGR 385
Cdd:PHA02874 226 PLHNAIIHNR-SAIELLINN--------------ASINDQDIDGSTPLhhAINPPCDI-DIIDILLYHKADISIKDNKGE 289
|
...
gi 55742489 386 NFL 388
Cdd:PHA02874 290 NPI 292
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
33-124 |
2.36e-12 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 63.98 E-value: 2.36e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 33 AFKGKASAIDRLIQKGPEhLSLRDENGASLLHYASAGGNLDIIRLIVSIVGPEVlnvqDEQGRTPLHWAVEQDQQQSCAV 112
Cdd:pfam12796 5 AKNGNLELVKLLLENGAD-ANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL----KDNGRTALHYAARSGHLEIVKL 79
|
90
....*....|..
gi 55742489 113 LLDLGADPNILN 124
Cdd:pfam12796 80 LLEKGADINVKD 91
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
448-964 |
1.50e-07 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 55.86 E-value: 1.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 448 LGQKSREKKSALHFAAE--YGRINTCHRLLET----LTDSKMLNDWD----EKGLTPLHLASRAGHAQVVDLLLRKGA-- 515
Cdd:TIGR00870 75 LSCRGAVGDTLLHAISLeyVDAVEAILLHLLAafrkSGPLELANDQYtsefTPGITALHLAAHRQNYEIVKLLLERGAsv 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 516 -------LFQSDyKGWTCLHH-------AAAEGYTQTMKILL--AANVKLLDEKnedGNTALHIAAqaghvsavlllldr 579
Cdd:TIGR00870 155 paracgdFFVKS-QGVDSFYHgesplnaAACLGSPSIVALLSedPADILTADSL---GNTLLHLLV-------------- 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 580 gaEIALNDADNSFLHEAVRNErrevvnATIEHERCDESM-----------TSFKaksrcvvLDIIEFLPESFQHLLdqci 648
Cdd:TIGR00870 217 --MENEFKAEYEELSCQMYNF------ALSLLDKLRDSKelevilnhqglTPLK-------LAAKEGRIVLFRLKL---- 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 649 tesdhdanSQDYHIMYNFQWLQAPIQLKKYAKT------DKTKAFQPLAA--LNAMVRYNRLELLIHPLSRkYLEMKWTA 720
Cdd:TIGR00870 278 --------AIKYKQKKFVAWPNGQQLLSLYWLEeldgwrRKQSVLELIVVfvIGLKFPELSDMYLIAPLSR-LGQFKWKP 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 721 YGSKVHFLNLAIYllgllpltylILNL---------RPSQDFSKGNGTSVIMVPVSFSE-QQYLISVCIIMVIVMNVYSI 790
Cdd:TIGR00870 349 FIKFIFHSASYLY----------FLYLiiftsvayyRPTRTDLRVTGLQQTPLEMLIVTwVDGLRLGEEKLIWLGGIFEY 418
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 791 CKEVVQLAQQRVN--YFTDFS-NPADWSAAISALVFVVPMCCSVEATwQWEAGAYAI--LTSWIgFLLYFQR-FERIGIY 864
Cdd:TIGR00870 419 IHQLWNILDFGMNsfYLATFLdRPFAILFVTQAFLVLREHWLRFDPT-LIEEALFAFalVLSWL-NLLYIFRgNQHLGPL 496
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 865 VVMFNG-IVRTLVCIMVLFVFLLLAFGLAFYALM-----LHRPEFSSISLALAQ-------TFVMTVGELnYQSTF-LNS 930
Cdd:TIGR00870 497 QIMIGRmILGDILRFLFIYAVVLFGFACGLNQLYqyydeLKLNECSNPHARSCEkqgnaysTLFETSQEL-FWAIIgLGD 575
|
570 580 590
....*....|....*....|....*....|....*
gi 55742489 931 YEEG-HMAFPAITYFVFVFFVLLMPILLMNLMIGL 964
Cdd:TIGR00870 576 LLANeHKFTEFVGLLLFGAYNVIMYILLLNMLIAM 610
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
162-358 |
1.18e-06 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 52.71 E-value: 1.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 162 NTPVMLACSNNNCQALQILIK-RGAKMCIQNKLGHYPIHTVAFAGAKEAMEMVLKIGEEL---GVSSTLhinYLDKsksT 237
Cdd:cd22192 18 ESPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPELvnePMTSDL---YQGE---T 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 238 PLHLAVRGGNIEVIKLCILKGAKV----------EQHQSGKC----TALHFACSQGSLEAVKIMLssyNRTEDIVNiRDG 303
Cdd:cd22192 92 ALHIAVVNQNLNLVRELIARGADVvspratgtffRPGPKNLIyygeHPLSFAACVGNEEIVRLLI---EHGADIRA-QDS 167
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 55742489 304 ANRTPLHratlfdhvelaeYLISKPNTLS----LDLIcLGKGAEIDSI------DCKGLSPLLLA 358
Cdd:cd22192 168 LGNTVLH------------ILVLQPNKTFacqmYDLI-LSYDKEDDLQpldlvpNNQGLTPFKLA 219
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
28-135 |
3.83e-06 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 50.79 E-value: 3.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 28 DVFELAFKGKASAIDRLIQKGPEHLSlRDENGASLLHYASAGG---NLDIIRLIVSIVGpevLNVQDEQGRTPLHWAVEQ 104
Cdd:PHA03095 192 HHHLQSFKPRARIVRELIRAGCDPAA-TDMLGNTPLHSMATGSsckRSLVLPLLIAGIS---INARNRYGQTPLHYAAVF 267
|
90 100 110
....*....|....*....|....*....|.
gi 55742489 105 DQQQSCAVLLDLGADPNILNNALMGPLHLAV 135
Cdd:PHA03095 268 NNPRACRRLIALGADINAVSSDGNTPLSLMV 298
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
556-583 |
5.11e-04 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 38.34 E-value: 5.11e-04
10 20
....*....|....*....|....*...
gi 55742489 556 DGNTALHIAAQAGHVSAVLLLLDRGAEI 583
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
237-262 |
6.98e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 35.26 E-value: 6.98e-03
10 20
....*....|....*....|....*.
gi 55742489 237 TPLHLAVRGGNIEVIKLCILKGAKVE 262
Cdd:smart00248 4 TPLHLAAENGNLEVVKLLLDKGADIN 29
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
370-611 |
1.23e-31 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 125.84 E-value: 1.23e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 370 LLSIGADFKIKEKTGRNFLHFVILQPKGLKNLPETVLQSTAVKEMLSDEDVEGCTPLHYACKLGIHDSVKNMLGLNICLG 449
Cdd:COG0666 2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 450 QKSREKKSALHFAAEYGRINTCHRLLETLTDskmLNDWDEKGLTPLHLASRAGHAQVVDLLLRKGA-LFQSDYKGWTCLH 528
Cdd:COG0666 82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGAD---VNARDKDGETPLHLAAYNGNLEIVKLLLEAGAdVNAQDNDGNTPLH 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 529 HAAAEGYTQTMKILLAANVKLlDEKNEDGNTALHIAAQAGHVSAVLLLLDRGAEI-ALNDADNSFLHEAVRNERREVVNA 607
Cdd:COG0666 159 LAAANGNLEIVKLLLEAGADV-NARDNDGETPLHLAAENGHLEIVKLLLEAGADVnAKDNDGKTALDLAAENGNLEIVKL 237
|
....
gi 55742489 608 TIEH 611
Cdd:COG0666 238 LLEA 241
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
111-394 |
1.55e-30 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 122.76 E-value: 1.55e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 111 AVLLDLGADPNILNNALMGPLHLAVTKQYNHLAEVLLSCDKTNSNLEGDLGNTPVMLACSNNNCQALQILIKRGAKMCIQ 190
Cdd:COG0666 4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 191 NKLGHYPIHTVAFAGAKEAMEMVLKIGeelgvsstLHINYLDKSKSTPLHLAVRGGNIEVIKLCILKGAKVEQHQSGKCT 270
Cdd:COG0666 84 DDGGNTLLHAAARNGDLEIVKLLLEAG--------ADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 271 ALHFACSQGSLEAVKIMLSSYnrteDIVNIRDGANRTPLHRATLFDHVELAEYLISkpntlsldliclgKGAEIDSIDCK 350
Cdd:COG0666 156 PLHLAAANGNLEIVKLLLEAG----ADVNARDNDGETPLHLAAENGHLEIVKLLLE-------------AGADVNAKDND 218
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 55742489 351 GLSPLLLASSCSAWKTVAYLLSIGADFKIKEKTGRNFLHFVILQ 394
Cdd:COG0666 219 GKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAA 262
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
41-325 |
7.88e-30 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 120.44 E-value: 7.88e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 41 IDRLIQKGPEHLSLRDENGASLLHYASAGGNLDIIRLIVSIVGPEVLNVQDEQGRTPLHWAVEQDQQQSCAVLLDLGADP 120
Cdd:COG0666 1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 121 NILNNALMGPLHLAVTKQYNHLAEVLLScDKTNSNLEGDLGNTPVMLACSNNNCQALQILIKRGAKMCIQNKLGHYPIHT 200
Cdd:COG0666 81 NAKDDGGNTLLHAAARNGDLEIVKLLLE-AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 201 VAFAGAKEAMEMVLKIGeelgvsstLHINYLDKSKSTPLHLAVRGGNIEVIKLCILKGAKVEQHQSGKCTALHFACSQGS 280
Cdd:COG0666 160 AAANGNLEIVKLLLEAG--------ADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGN 231
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 55742489 281 LEAVKIMLSSYNRtediVNIRDGANRTPLHRATLFDHVELAEYLI 325
Cdd:COG0666 232 LEIVKLLLEAGAD----LNAKDKDGLTALLLAAAAGAALIVKLLL 272
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
17-272 |
4.49e-29 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 118.52 E-value: 4.49e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 17 VINEDETEESADVFELAFKGKASAIDRLIQKGPEHLSLRDENGASLLHYASAGGNLDIIRLIVSivGPEVLNVQDEQGRT 96
Cdd:COG0666 45 LALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLE--AGADVNARDKDGET 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 97 PLHWAVEQDQQQSCAVLLDLGADPNILNNALMGPLHLAVTKQYNHLAEVLLSCdKTNSNLEGDLGNTPVMLACSNNNCQA 176
Cdd:COG0666 123 PLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA-GADVNARDNDGETPLHLAAENGHLEI 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 177 LQILIKRGAKMCIQNKLGHYPIHTVAFAGAKEAMEMVLKIGEElgvsstlhINYLDKSKSTPLHLAVRGGNIEVIKLCIL 256
Cdd:COG0666 202 VKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGAD--------LNAKDKDGLTALLLAAAAGAALIVKLLLL 273
|
250
....*....|....*.
gi 55742489 257 KGAKVEQHQSGKCTAL 272
Cdd:COG0666 274 ALLLLAAALLDLLTLL 289
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
331-610 |
8.67e-27 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 111.58 E-value: 8.67e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 331 LSLDLICLGKGAEIDSIDCKGLSPLLLASSCSAWKTVAYLLSIGADFKIKEKTGRNFLHFVILqpkglKNLPETVLQSTA 410
Cdd:COG0666 1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAAL-----AGDLLVALLLLA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 411 VKEMLSDEDVEGCTPLHYACKLGIHDSVKNMLGLNICLGQKSREKKSALHFAAEYGRINTCHRLLETLTDskmLNDWDEK 490
Cdd:COG0666 76 AGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGAD---VNAQDND 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 491 GLTPLHLASRAGHAQVVDLLLRKGA-LFQSDYKGWTCLHHAAAEGYTQTMKILLAANVKlLDEKNEDGNTALHIAAQAGH 569
Cdd:COG0666 153 GNTPLHLAAANGNLEIVKLLLEAGAdVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD-VNAKDNDGKTALDLAAENGN 231
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 55742489 570 VSAVLLLLDRGAEIALNDAD-NSFLHEAVRNERREVVNATIE 610
Cdd:COG0666 232 LEIVKLLLEAGADLNAKDKDgLTALLLAAAAGAALIVKLLLL 273
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
202-590 |
1.71e-22 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 99.26 E-value: 1.71e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 202 AFAGAKEAMEMVLKIGEELGVSSTLHINYLDKSKSTPLHLAVRGGNIEVIKLCILKGAKVEQHQSGKCTALHFACSQGSL 281
Cdd:COG0666 21 LALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 282 EAVKIMLSSynrtEDIVNIRDGANRTPLHRATLFDHVELAEYLISKpntlsldliclgkGAEIDSIDCKGLSPLLLASSC 361
Cdd:COG0666 101 EIVKLLLEA----GADVNARDKDGETPLHLAAYNGNLEIVKLLLEA-------------GADVNAQDNDGNTPLHLAAAN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 362 SAWKTVAYLLSIGADfkikektgrnflhfvilqpkglknlpetvlqstavkemlsdedvegctplhyacklgihdsvknm 441
Cdd:COG0666 164 GNLEIVKLLLEAGAD----------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 442 lglniclgqksrekksalhfaaeygrintchrlletltdskmLNDWDEKGLTPLHLASRAGHAQVVDLLLRKGA-LFQSD 520
Cdd:COG0666 179 ------------------------------------------VNARDNDGETPLHLAAENGHLEIVKLLLEAGAdVNAKD 216
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 521 YKGWTCLHHAAAEGYTQTMKILLAANvKLLDEKNEDGNTALHIAAQAGHVSAVLLLLDRGAEIALNDADN 590
Cdd:COG0666 217 NDGKTALDLAAENGNLEIVKLLLEAG-ADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDL 285
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
438-611 |
8.10e-19 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 88.09 E-value: 8.10e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 438 VKNMLGLNICLGQKSREKKSALHFAAEYGRINTCHRLLETLTDSKMLNDWDEKGLTPLHLASRAGHAQVVDLLLRKGA-L 516
Cdd:COG0666 1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGAdI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 517 FQSDYKGWTCLHHAAAEGYTQTMKILLAANVKLlDEKNEDGNTALHIAAQAGHVSAVLLLLDRGAEI-ALNDADNSFLHE 595
Cdd:COG0666 81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADV-NARDKDGETPLHLAAYNGNLEIVKLLLEAGADVnAQDNDGNTPLHL 159
|
170
....*....|....*.
gi 55742489 596 AVRNERREVVNATIEH 611
Cdd:COG0666 160 AAANGNLEIVKLLLEA 175
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
495-587 |
6.53e-18 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 79.77 E-value: 6.53e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 495 LHLASRAGHAQVVDLLLRKGA-LFQSDYKGWTCLHHAAAEGYTQTMKILLAANVKlldEKNEDGNTALHIAAQAGHVSAV 573
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGAdANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV---NLKDNGRTALHYAARSGHLEIV 77
|
90
....*....|....
gi 55742489 574 LLLLDRGAEIALND 587
Cdd:pfam12796 78 KLLLEKGADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
239-327 |
2.24e-14 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 69.76 E-value: 2.24e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 239 LHLAVRGGNIEVIKLCILKGAKVEQHQSGKCTALHFACSQGSLEAVKIMLSSYNrtediVNIRDGaNRTPLHRATLFDHV 318
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD-----VNLKDN-GRTALHYAARSGHL 74
|
....*....
gi 55742489 319 ELAEYLISK 327
Cdd:pfam12796 75 EIVKLLLEK 83
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
228-515 |
8.55e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 74.70 E-value: 8.55e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 228 INYLDKSKSTPLHLAVRGGNIEVIKLCILKGAKVEQHQSGKCTALHFAcsqgsleavkimlssynrTEDIVNIRDGanrt 307
Cdd:PHA03100 28 NDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYL------------------SNIKYNLTDV---- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 308 plhratlfdhVELAEYLISkpntlsldliclgKGAEIDSIDCKGLSPLLLASSCSA--WKTVAYLLSIGADFKIKEKTGR 385
Cdd:PHA03100 86 ----------KEIVKLLLE-------------YGANVNAPDNNGITPLLYAISKKSnsYSIVEYLLDNGANVNIKNSDGE 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 386 NFLHFVILQPKGLKNLPETVLQSTAvkemlsdeDVEGCTPLHYACKLGIHDSVKNMLGlniclgqksrekKSALHFAAEY 465
Cdd:PHA03100 143 NLLHLYLESNKIDLKILKLLIDKGV--------DINAKNRVNYLLSYGVPINIKDVYG------------FTPLHYAVYN 202
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 55742489 466 GRINTCHRLLETLTDskmLNDWDEKGLTPLHLASRAGHAQVVDLLLRKGA 515
Cdd:PHA03100 203 NNPEFVKYLLDLGAN---PNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
|
|
| Ion_trans |
pfam00520 |
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ... |
759-977 |
8.83e-14 |
|
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.
Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 72.30 E-value: 8.83e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 759 TSVIMVPV--SFSEQQYLISVCIIMVIVMNVYSICKEVVQLAQQRV--NYFTDFSNPADWSAAISALVFVVPmccsveaT 834
Cdd:pfam00520 14 LNTIFLALetYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkkRYFRSPWNILDFVVVLPSLISLVL-------S 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 835 WQWEAGAYAILTSW--IGFLLYFQRFERIGIYVVMFNGIVRTLVCIMVLFVFLLLAFGLAFYAL-----------MLHRP 901
Cdd:pfam00520 87 SVGSLSGLRVLRLLrlLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLfggklktwenpDNGRT 166
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 55742489 902 EFSSISLALAQTFVMTVGElNYQSTFLNSYEEGHmafPAITYFVFVFFVLLMPILLMNLMIGLAVGDIAEVQRNAE 977
Cdd:pfam00520 167 NFDNFPNAFLWLFQTMTTE-GWGDIMYDTIDGKG---EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
|
|
| TRPV |
cd21882 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ... |
456-1002 |
5.28e-13 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).
Pssm-ID: 411975 [Multi-domain] Cd Length: 600 Bit Score: 72.99 E-value: 5.28e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 456 KSALHFAAEY---GRINTCHRLLETLTDSKMLNDW------DE--KGLTPLHLASRAGHAQVVDLLLRKGA--------- 515
Cdd:cd21882 27 KTCLHKAALNlndGVNEAIMLLLEAAPDSGNPKELvnapctDEfyQGQTALHIAIENRNLNLVRLLVENGAdvsaratgr 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 516 LFQSD-----YKGWTCLHHAAAEGYTQTMKILL--AANVKLLDEKNEDGNTALHIAAqaghvsavlllldrgaEIALNDA 588
Cdd:cd21882 107 FFRKSpgnlfYFGELPLSLAACTNQEEIVRLLLenGAQPAALEAQDSLGNTVLHALV----------------LQADNTP 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 589 DNSFLHEAVRNE-----RREVVNATIEHERCDESMTSFKaksrcvvLDIIEFLPESFQHLLDQCITESDHdansqdyHIM 663
Cdd:cd21882 171 ENSAFVCQMYNLllsygAHLDPTQQLEEIPNHQGLTPLK-------LAAVEGKIVMFQHILQREFSGPYQ-------PLS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 664 YNF-QWLQAPIQLKKYAKTD----KTKAFQPLAALNAMVRYNRLELLIHPLsRKYLEMKWTAYGSKVHFLNLAIYLLGLL 738
Cdd:cd21882 237 RKFtEWTYGPVTSSLYDLSEidswEKNSVLELIAFSKKREARHQMLVQEPL-NELLQEKWDRYGRPYFCFNFACYLLYMI 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 739 PLTYLILNlRPSQDfsKGNGTSVIMVPvsfseQQYLISVCIIMVIVMNVYSICKEVVQLAQQRVNYFTDF-SNPADWSAA 817
Cdd:cd21882 316 IFTVCAYY-RPLKD--RPANQEAKATF-----GDSIRLVGEILTVLGGVYILLGEIPYFFRRRLSRWFGFlDSYFEILFI 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 818 ISALVFVVPMCCS-VEATWQWEAGAYAILTSWIGFLLYFQRFERIGIYVVMFNG-IVRTLVCIMVLFVFLLLAFGLAFYA 895
Cdd:cd21882 388 TQALLVLLSMVLRfMETEGYVVPLVFSLVLGWCNVLYYTRGFQMLGIYTVMIQKmILRDLMRFCWVYLVFLFGFASAFVI 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 896 LML-----HRPEFSSISLALAQTFVMTVG----ELNYQstflnsyeeghMAFPAITYFVFVFFVLLMPILLMNLMIGL-- 964
Cdd:cd21882 468 LFQtedpnKLGEFRDYPDALLELFKFTIGmgdlPFNEN-----------VDFPFVYLILLLAYVILTYLLLLNMLIALmg 536
|
570 580 590 600
....*....|....*....|....*....|....*....|
gi 55742489 965 -AVGDIAEVQRNA-ELKRIAMQIDlhtaLEEKLPYWFLKR 1002
Cdd:cd21882 537 eTVNRVAQESDEIwKLQKAITTLM----LERKYPRCLRKR 572
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
70-388 |
9.11e-13 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 71.92 E-value: 9.11e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 70 GNLDIIRLIVSIVGpEVLNVQDEQGRTPLHWAVEQDQQQSCAVLLDLGADPNILNNALMGPLHLAVTKQYNHLAEVLLSC 149
Cdd:PHA02874 12 GDIEAIEKIIKNKG-NCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDN 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 150 DKTNSNLegdlgntPVmlACSNNncQALQILIKRGAKMCIQNKLGHYPIHTVAFAGAKEAMEMVLKIGEElgvsstlhIN 229
Cdd:PHA02874 91 GVDTSIL-------PI--PCIEK--DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGAD--------VN 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 230 YLDKSKSTPLHLAVRGGNIEVIKLCILKGAKVEQHQSGKCTALHFACSQGSLEAVKIMLSSYNrtedivNIRDGANR--T 307
Cdd:PHA02874 152 IEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGN------HIMNKCKNgfT 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 308 PLHRATLFDHvELAEYLISKpntlsldliclgkgAEIDSIDCKGLSPL--LLASSCSAwKTVAYLLSIGADFKIKEKTGR 385
Cdd:PHA02874 226 PLHNAIIHNR-SAIELLINN--------------ASINDQDIDGSTPLhhAINPPCDI-DIIDILLYHKADISIKDNKGE 289
|
...
gi 55742489 386 NFL 388
Cdd:PHA02874 290 NPI 292
|
|
| TRPV3 |
cd22194 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ... |
520-1002 |
1.56e-12 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411978 [Multi-domain] Cd Length: 680 Bit Score: 71.71 E-value: 1.56e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 520 DYKGWTCLHHAAAEGYTQTMKILLA--ANVK------LLDEKNED-----GNTALHIAAQAGHVSAVLLLLDRGAE-IAL 585
Cdd:cd22194 138 AYEGQTALNIAIERRQGDIVKLLIAkgADVNahakgvFFNPKYKHegfyfGETPLALAACTNQPEIVQLLMEKESTdITS 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 586 NDA-DNSFLHEAVR-NERREVVNATIEhERCDESMTSFKAKSRCVVLDIIEFLP----------ESFQHLLDQCITESDH 653
Cdd:cd22194 218 QDSrGNTVLHALVTvAEDSKTQNDFVK-RMYDMILLKSENKNLETIRNNEGLTPlqlaakmgkaEILKYILSREIKEKPN 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 654 DANSQDYhimynFQWLQAPIQLKKYAKTDkTKAFQPLAALNAMVrYN-----RLELL-IHPLsRKYLEMKWTAYGSKVHF 727
Cdd:cd22194 297 RSLSRKF-----TDWAYGPVSSSLYDLTN-VDTTTDNSVLEIIV-YNtnidnRHEMLtLEPL-HTLLHMKWKKFARYMFF 368
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 728 LNLAIYLLGLLpltylILNL----RPSQD--------FSKGNGtsvimvPVSFSEQQYLIsVCIIMVIVMNVYSI----- 790
Cdd:cd22194 369 ISFLFYFFYNI-----TLTLvsyyRPREDedpphplaLSHKMG------WLQLLGQMFVL-IWATCLSVKEGIAIfllrp 436
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 791 --CKEVVQLAQQRVNYFTDfsnpadwsaaiSALVFVVPMCCSVEATWQWEAGAYAILTSWIGFLLYFQRFERIGIYVVMF 868
Cdd:cd22194 437 sdLKSILSDAWFHILFFIQ-----------AVLVIVSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSLGIYSVMI 505
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 869 NG-IVRTLVCIMVLFVFLLLAFGLAFYALMLHRPE------FSSISLALAQTFVMTVG--ELNYQStflnsyeegHMAFP 939
Cdd:cd22194 506 QKvILNDVLKFLLVYILFLLGFGVALASLIEDCPDdsecssYGSFSDAVLELFKLTIGlgDLEIQQ---------NSKYP 576
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 55742489 940 AITYFVFVFFVLLMPILLMNLMIGLAVGDIAEVQRNAE----LKRiAMQIdlhTALEEKLPYWFLKR 1002
Cdd:cd22194 577 ILFLLLLITYVILTFVLLLNMLIALMGETVENVSKESEriwrLQR-ARTI---LEFEKSLPEWLRKR 639
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
426-515 |
1.61e-12 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 64.37 E-value: 1.61e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 426 LHYACKLGIHDSVKNMLGLNICLGQKSREKKSALHFAAEYGRINTCHRLLEtltdsKMLNDWDEKGLTPLHLASRAGHAQ 505
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-----HADVNLKDNGRTALHYAARSGHLE 75
|
90
....*....|
gi 55742489 506 VVDLLLRKGA 515
Cdd:pfam12796 76 IVKLLLEKGA 85
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
33-124 |
2.36e-12 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 63.98 E-value: 2.36e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 33 AFKGKASAIDRLIQKGPEhLSLRDENGASLLHYASAGGNLDIIRLIVSIVGPEVlnvqDEQGRTPLHWAVEQDQQQSCAV 112
Cdd:pfam12796 5 AKNGNLELVKLLLENGAD-ANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNL----KDNGRTALHYAARSGHLEIVKL 79
|
90
....*....|..
gi 55742489 113 LLDLGADPNILN 124
Cdd:pfam12796 80 LLEKGADINVKD 91
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
424-996 |
2.45e-12 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 71.20 E-value: 2.45e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 424 TPLHYACKLGIHDSVKNMLGLNIC-LGQKSREKKSALHFAAEYGRINTCHRLLE---TLTDSKMLNDWDEkGLTPLHLAS 499
Cdd:cd22192 19 SPLLLAAKENDVQAIKKLLKCPSCdLFQRGALGETALHVAALYDNLEAAVVLMEaapELVNEPMTSDLYQ-GETALHIAV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 500 RAGHAQVVDLLLRKGALFQSD---------------YKGWTCLHHAAAEGYTQTMKILLAANVkllDEKNED--GNTALH 562
Cdd:cd22192 98 VNQNLNLVRELIARGADVVSPratgtffrpgpknliYYGEHPLSFAACVGNEEIVRLLIEHGA---DIRAQDslGNTVLH 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 563 IaaqaghvsavlLLLDRGAEIALNDADnsFLHEAVRNERrevvNATIEHERCDESMTSFK--AKSRCVVLdiieflpesF 640
Cdd:cd22192 175 I-----------LVLQPNKTFACQMYD--LILSYDKEDD----LQPLDLVPNNQGLTPFKlaAKEGNIVM---------F 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 641 QHLLdqcitesdhdanSQDYHIMYNFQ--------------WLQAPIQLKKYAKTDKTKAFQPLAalnamvrynrlellI 706
Cdd:cd22192 229 QHLV------------QKRRHIQWTYGpltstlydlteidsWGDEQSVLELIVSSKKREARKILD--------------V 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 707 HPLsRKYLEMKWTAYGSKVHFLNLAIYLLGLLPLTYLI----LNLRPSQDFSKGNGTSVIMVPVSFSEQQY--------- 773
Cdd:cd22192 283 TPV-KELVSLKWKRYGRPYFRILALLYLLYIIIFTLCCvyrpLKPRPENNTDPRDITLYVQKTLQESYVTPkdylrlvge 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 774 LISVCIIMVI-VMNVYSICKEVVQLaqqrvnYF--TDFSNPAD---WSAAISALVFVVPMCCSVEAtwQWEAGAYAILTS 847
Cdd:cd22192 362 LISVLGAIVIlLLEIPDILRVGVKR------YFgqTVLGGPFHviiITYACLVLLTLVLRLTSLSG--EVVPMSLALVLG 433
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 848 WiGFLLYFQR-FERIGIYVVMFNGIV-RTLVCIMVLFVFLLLAFGLAFYalMLHRPE-------FSSISLALAQTFVMTV 918
Cdd:cd22192 434 W-CNVMYFARgFQMLGPFTIMIQKIIfGDLMKFCWLMFVVILGFSSAFY--MIFQTEdpdslghFYDFPMTLFSTFELFL 510
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 919 GELNYqstFLNsyeeGHMAFPAITYFVFVFFVLLMPILLMNLMIGLAVGDIAEV--QRNaELKRiaMQIDLHT-ALEEKL 995
Cdd:cd22192 511 GLIDG---PAN----YTVDLPFMYKVLYTAFAVIAYLLMLNLLIAMMGDTHWRVahERD-ELWR--AQVVATTlMLERRL 580
|
.
gi 55742489 996 P 996
Cdd:cd22192 581 P 581
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
527-612 |
5.15e-12 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 62.83 E-value: 5.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 527 LHHAAAEGYTQTMKILLAANVKLlDEKNEDGNTALHIAAQAGHVSAVLLLLDRgAEIALNDADNSFLHEAVRNERREVVN 606
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADA-NLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVK 78
|
....*.
gi 55742489 607 ATIEHE 612
Cdd:pfam12796 79 LLLEKG 84
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
98-191 |
9.24e-12 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 62.06 E-value: 9.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 98 LHWAVEQDQQQSCAVLLDLGADPNILNNALMGPLHLAVTKQYNHLAEVLLSCDKTNSNlegDLGNTPVMLACSNNNCQAL 177
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHLEIV 77
|
90
....*....|....
gi 55742489 178 QILIKRGAKMCIQN 191
Cdd:pfam12796 78 KLLLEKGADINVKD 91
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
73-257 |
1.23e-11 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 68.37 E-value: 1.23e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 73 DIIRLIVSiVGPEVLNVQDEQGRTPLHWAVEQDQQQSCAVLLDLGADPNILNNALMGPLHLAVTKQYNHLAEVLLScDKT 152
Cdd:PHA02878 148 EITKLLLS-YGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLE-NGA 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 153 NSNLEGDLGNTPVMLACSN-NNCQALQILIKRGAKMCIQNK-LGHYPIHTVAFAgakeamEMVLKIGEELGVSstlhINY 230
Cdd:PHA02878 226 STDARDKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYiLGLTALHSSIKS------ERKLKLLLEYGAD----INS 295
|
170 180 190
....*....|....*....|....*....|...
gi 55742489 231 LDKSKSTPLHLAVRG------GNIEVIKLCILK 257
Cdd:PHA02878 296 LNSYKLTPLSSAVKQylciniGRILISNICLLK 328
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
70-289 |
4.23e-11 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 66.55 E-value: 4.23e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 70 GNLDIIRLIVSI-VGPevlNVQDEQGRTPLHWAVEQDQQQSCAVLLDLGADPNILNNALMGPLHLAVTKQYNHLAEVLLS 148
Cdd:PHA02875 13 GELDIARRLLDIgINP---NFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLD 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 149 CDKTNSNLEGDLGNTPVMLACSNNNCQALQILIKRGAKMCIQNKLGHYPIHTVAFAGAKEAMEMVLKigeelgVSSTLHI 228
Cdd:PHA02875 90 LGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLID------HKACLDI 163
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 55742489 229 NylDKSKSTPLHLAVRGGNIEVIKLCILKGAKVEQ-HQSGKCTALHFACSQGSLEAVKIMLS 289
Cdd:PHA02875 164 E--DCCGCTPLIIAMAKGDIAICKMLLDSGANIDYfGKNGCVAALCYAIENNKIDIVRLFIK 223
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
279-530 |
4.42e-11 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 66.53 E-value: 4.42e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 279 GSLEAVKIMLSsyNRTeDIVNIRDGANRTPLHRATLFDHVELAEYLISK-----------PNTLsLDLICLGKGAEIDSI 347
Cdd:PHA02874 12 GDIEAIEKIIK--NKG-NCINISVDETTTPLIDAIRSGDAKIVELFIKHgadinhintkiPHPL-LTAIKIGAHDIIKLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 348 DCKGLSPLLLASSCSAWKTVAYLLSIGADFKIKEKTGRNFLHFVILqpkglKNLPETVLQSTAVKEMLSDEDVEGCTPLH 427
Cdd:PHA02874 88 IDNGVDTSILPIPCIEKDMIKTILDCGIDVNIKDAELKTFLHYAIK-----KGDLESIKMLFEYGADVNIEDDNGCYPIH 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 428 YACKLGIHDSVKNMLGLNICLGQKSREKKSALHFAAEYGRINTCHRLletLTDSKMLNDWDEKGLTPLHLASRAGHAqVV 507
Cdd:PHA02874 163 IAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLL---IDHGNHIMNKCKNGFTPLHNAIIHNRS-AI 238
|
250 260
....*....|....*....|...
gi 55742489 508 DLLLRKGALFQSDYKGWTCLHHA 530
Cdd:PHA02874 239 ELLINNASINDQDIDGSTPLHHA 261
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
272-380 |
1.81e-10 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 58.59 E-value: 1.81e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 272 LHFACSQGSLEAVKIMLSSynrtEDIVNIRDGANRTPLHRATLFDHVELAEYLISKPNTlsldliclgkgaeidSIDCKG 351
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLEN----GADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV---------------NLKDNG 61
|
90 100
....*....|....*....|....*....
gi 55742489 352 LSPLLLASSCSAWKTVAYLLSIGADFKIK 380
Cdd:pfam12796 62 RTALHYAARSGHLEIVKLLLEKGADINVK 90
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
227-556 |
2.98e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 64.13 E-value: 2.98e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 227 HINYLDKSKS----------TPLHLAVRGGNIEVIKLCILKGAKVEQHQSGKCTALHFACSQGSLEAVKIMLSSYNRTE- 295
Cdd:PHA02878 19 YIEYIDHTENystsaslipfIPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSv 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 296 --DIVNIRDGANrtplhratlFDHVELAEYLISKP--NTLSLDLICLGKGAEIDSIDCkglsplllasscsawKTVAYLL 371
Cdd:PHA02878 99 fyTLVAIKDAFN---------NRNVEIFKIILTNRykNIQTIDLVYIDKKSKDDIIEA---------------EITKLLL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 372 SIGADFKIKEK-TGRNFLHFVILQPKglKNLPETVLQSTAVKEMLsdeDVEGCTPLHYACKLGIHDSVKNMLGLNICLGQ 450
Cdd:PHA02878 155 SYGADINMKDRhKGNTALHYATENKD--QRLTELLLSYGANVNIP---DKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 451 KSREKKSALHFAAEYGR-INTCHRLLETLTD----SKMLndwdekGLTPLHLASRAghAQVVDLLLRKGALFQS-DYKGW 524
Cdd:PHA02878 230 RDKCGNTPLHISVGYCKdYDILKLLLEHGVDvnakSYIL------GLTALHSSIKS--ERKLKLLLEYGADINSlNSYKL 301
|
330 340 350
....*....|....*....|....*....|..
gi 55742489 525 TCLHHAAAEGYTQTMKILLAANVKLLDEKNED 556
Cdd:PHA02878 302 TPLSSAVKQYLCINIGRILISNICLLKRIKPD 333
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
96-299 |
4.04e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 63.15 E-value: 4.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 96 TPLHWAVEQDQQQSCAVLLDLGADPNILNNALMGPLHLAVTKQYN-----HLAEVLLScDKTNSNLEGDLGNTPVMLACS 170
Cdd:PHA03100 37 LPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLE-YGANVNAPDNNGITPLLYAIS 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 171 NNNCQA--LQILIKRGAKMCIQNKLGHYPIHTVAFAGAKEamemvLKIGEEL---GV------------SSTLHINYLDK 233
Cdd:PHA03100 116 KKSNSYsiVEYLLDNGANVNIKNSDGENLLHLYLESNKID-----LKILKLLidkGVdinaknrvnyllSYGVPINIKDV 190
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 55742489 234 SKSTPLHLAVRGGNIEVIKLCILKGAKVEQHQSGKCTALHFACSQGSLEAVKIMLSSYNRTEDIVN 299
Cdd:PHA03100 191 YGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIE 256
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
434-617 |
6.73e-10 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 63.38 E-value: 6.73e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 434 IHDSVKNMLGLNICLGQKSREKKSALHFAA----EYGRINTchrLLETLTDSKMLNDWDEKGLTPLHLASRA-GHAQVVD 508
Cdd:PTZ00322 9 ASSAFAAQLFFGTEGSRKRRAKPISFERMAaiqeEIARIDT---HLEALEATENKDATPDHNLTTEEVIDPVvAHMLTVE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 509 LllrkgalfqsdykgwtClhHAAAEGYTQTMKILLAANVKLlDEKNEDGNTALHIAAQAGHVSAVLLLLDRGAEIALNDA 588
Cdd:PTZ00322 86 L----------------C--QLAASGDAVGARILLTGGADP-NCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDK 146
|
170 180 190
....*....|....*....|....*....|
gi 55742489 589 D-NSFLHEAVRNERREVVNATIEHERCDES 617
Cdd:PTZ00322 147 DgKTPLELAEENGFREVVQLLSRHSQCHFE 176
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
41-378 |
1.05e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 62.77 E-value: 1.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 41 IDRLIQKGPEHLSLRDENGASLLHYASAGGNLDIIRLIVSiVGPEVlNVQDEQGRTPLHWAVEQDQ-------------- 106
Cdd:PHA02876 160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLS-YGADV-NIIALDDLSVLECAVDSKNidtikaiidnrsni 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 107 ---------------QQSCAVLLDLGADPNILNNALMGPLHLAV-TKQYNHLAEVLLS--CDKTNSNLEGDlgnTPVMLA 168
Cdd:PHA02876 238 nkndlsllkairnedLETSLLLYDAGFSVNSIDDCKNTPLHHASqAPSLSRLVPKLLErgADVNAKNIKGE---TPLYLM 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 169 CSNN-NCQALQILIKRGAKMCIQNKLGHYPIHTVA-FAGAKEAMEMVLKIGEelgvsstlHINYLDKSKSTPLHLAVRGG 246
Cdd:PHA02876 315 AKNGyDTENIRTLIMLGADVNAADRLYITPLHQAStLDRNKDIVITLLELGA--------NVNARDYCDKTPIHYAAVRN 386
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 247 NIEVIKLCILKGAKVEQHQSGKCTALHFA-CSQGSLEAVKIMLssyNRTEDiVNIRDGANRTPLHRATlfdhvelaeyli 325
Cdd:PHA02876 387 NVVIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLI---DRGAN-VNSKNKDLSTPLHYAC------------ 450
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 55742489 326 skPNTLSLDLI--CLGKGAEIDSIDCKGLSPLLLASSCSAwkTVAYLLSIGADFK 378
Cdd:PHA02876 451 --KKNCKLDVIemLLDNGADVNAINIQNQYPLLIALEYHG--IVNILLHYGAELR 501
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
166-261 |
1.16e-09 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 56.28 E-value: 1.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 166 MLACSNNNCQALQILIKRGAKMCIQNKLGHYPIHTVAFAGAKEAMEMVLKigeelgvsstlHINY-LDKSKSTPLHLAVR 244
Cdd:pfam12796 2 HLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-----------HADVnLKDNGRTALHYAAR 70
|
90
....*....|....*..
gi 55742489 245 GGNIEVIKLCILKGAKV 261
Cdd:pfam12796 71 SGHLEIVKLLLEKGADI 87
|
|
| TRPV1-4 |
cd22193 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ... |
490-1002 |
1.24e-09 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411977 [Multi-domain] Cd Length: 607 Bit Score: 62.12 E-value: 1.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 490 KGLTPLHLASRAGHAQVVDLLLRKGALFQSDYKGWTCLHHAAAEG-YTQTMKILLAANVKLLDEKN---EDGNTALHIAA 565
Cdd:cd22193 75 EGQTALHIAIERRQGDIVALLVENGADVHAHAKGRFFQPKYQGEGfYFGELPLSLAACTNQPDIVQyllENEHQPADIEA 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 566 QAGHVSAVLLLLdrgAEIALNDADNSFLHEAVRNE-----RREVVNATIEHERCDESMTSFKAKSRCVVLDIieflpesF 640
Cdd:cd22193 155 QDSRGNTVLHAL---VTVADNTKENTKFVTRMYDMilirgAKLCPTVELEEIRNNDGLTPLQLAAKMGKIEI-------L 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 641 QHLLDQCITESDHDANSQDYHimynfQWLQAPIQLKKY----AKTDKTKAFQPLAALNAMVRYNRLELLIHPLSRkYLEM 716
Cdd:cd22193 225 KYILQREIKEPELRHLSRKFT-----DWAYGPVSSSLYdlsnVDTCEKNSVLEIIVYNSKIDNRHEMLTLEPLNT-LLQD 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 717 KWTAYGSKVHFLNLAIYLLGLLPLTYlILNLRPSQDfskgngTSVIMVPVSfSEQQYLISVCIIMVIVMNVYSICKEVVQ 796
Cdd:cd22193 299 KWDKFAKYMFFFSFCFYLFYMIIFTL-VAYYRPRED------EPPPPLAKT-TKMDYMRLLGEILVLLGGVYFFVKEIAY 370
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 797 LAQQRVNYFTDFSnpaDWSAAISALVFVVPMCCSV-----EATWQWEAGAYAILTSWIGFLLYFQRFERIGIYVVMFNGI 871
Cdd:cd22193 371 FLLRRSDLQSSFS---DSYFEILFFVQAVLVILSVvlylfAYKEYLACLVLALALGWANMLYYTRGFQSMGIYSVMIQKV 447
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 872 VRTLVCiMVLFVFLLLAFGLAFYALMLHRP---------EFSSISLALAQTFVMTVG--ELNYQstflNSYEeghmaFPA 940
Cdd:cd22193 448 ILRDLL-RFLFVYLLFLFGFAVALVSLIEKcssdkkdcsSYGSFSDAVLELFKLTIGmgDLEFQ----ENST-----YPA 517
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 55742489 941 ITYFVFVFFVLLMPILLMNLMIGLAVGDIAEVQRNAE----LKRIAMQIDlhtaLEEKLPYWFLKR 1002
Cdd:cd22193 518 VFLILLLTYVILTFVLLLNMLIALMGETVNNVSKESKriwkLQRAITILE----FEKSFPECMRKA 579
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
298-607 |
1.33e-09 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 61.96 E-value: 1.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 298 VNIRDGANRTPLHratlfdhvelaeYLISKPNTLSLDLI--CLGKGAEIDSIDCKGLSPL-LLASSCSAWKTVAYLLSIG 374
Cdd:PHA03095 40 VNFRGEYGKTPLH------------LYLHYSSEKVKDIVrlLLEAGADVNAPERCGFTPLhLYLYNATTLDVIKLLIKAG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 375 ADFKIKEKTGRNFLHfvilqpKGLKNL---PETVLQSTAVKEMLSDEDVEGCTPLHyaCKLGIHDSVKNMLGLNICLGQK 451
Cdd:PHA03095 108 ADVNAKDKVGRTPLH------VYLSGFninPKVIRLLLRKGADVNALDLYGMTPLA--VLLKSRNANVELLRLLIDAGAD 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 452 SREKK----SALHFAAEYGRINTchRLLETLTDSKM-LNDWDEKGLTPLHlaSRAGHAQVVDLLLRKgalfqsdykgwtc 526
Cdd:PHA03095 180 VYAVDdrfrSLLHHHLQSFKPRA--RIVRELIRAGCdPAATDMLGNTPLH--SMATGSSCKRSLVLP------------- 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 527 lhhaaaegytqtmkiLLAANVKLlDEKNEDGNTALHIAAQAGHVSAVLLLLDRGAEIALNDAD-NSFLHEAVRNERREVV 605
Cdd:PHA03095 243 ---------------LLIAGISI-NARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDgNTPLSLMVRNNNGRAV 306
|
..
gi 55742489 606 NA 607
Cdd:PHA03095 307 RA 308
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
50-358 |
1.43e-09 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 61.96 E-value: 1.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 50 EHLSLRDENGASLLHYASAGGNLDI--IRLIVSiVGPEVlNVQDEQGRTPLHWAVEQDQQQSCAV---LLDLGADPNILN 124
Cdd:PHA03095 3 EDESVDIIMEAALYDYLLNASNVTVeeVRRLLA-AGADV-NFRGEYGKTPLHLYLHYSSEKVKDIvrlLLEAGADVNAPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 125 NALMGPLHLAVTKQYN-HLAEVLLSCdKTNSNLEGDLGNTPVMLACSNNNCQA--LQILIKRGAKMCIQNKLGHYPIHT- 200
Cdd:PHA03095 81 RCGFTPLHLYLYNATTlDVIKLLIKA-GADVNAKDKVGRTPLHVYLSGFNINPkvIRLLLRKGADVNALDLYGMTPLAVl 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 201 VAFAGAKEAM--EMVLKIGEELGVS----STLHI--NYLDKSKStplhlavrggnieVIKLCILKGAKVEQHQSGKCTAL 272
Cdd:PHA03095 160 LKSRNANVELlrLLIDAGADVYAVDdrfrSLLHHhlQSFKPRAR-------------IVRELIRAGCDPAATDMLGNTPL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 273 HFACSQGSLEAVKImlSSYNRTEDIVNIRDGANRTPLHRATLFDHVELAEYLISkpntlsldliclgKGAEIDSIDCKGL 352
Cdd:PHA03095 227 HSMATGSSCKRSLV--LPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIA-------------LGADINAVSSDGN 291
|
....*.
gi 55742489 353 SPLLLA 358
Cdd:PHA03095 292 TPLSLM 297
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
423-611 |
2.17e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 60.83 E-value: 2.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 423 CTPLHYACKLGIHDSVKNMLGLNICLGQKSREKKSALHFAAEYGRINTCHR-----LLETLTDSKMLNDwdeKGLTPLHL 497
Cdd:PHA03100 36 VLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLTDVKeivklLLEYGANVNAPDN---NGITPLLY 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 498 AS--RAGHAQVVDLLLRKGALFQSDYKGWTCLHHAAAEGYTQTMKIL-----------LAANVKLL-------DEKNEDG 557
Cdd:PHA03100 113 AIskKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLKILkllidkgvdinAKNRVNYLlsygvpiNIKDVYG 192
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 55742489 558 NTALHIAAQAGHVSAVLLLLDRGAEI-ALNDADNSFLHEAVRNERREVVNATIEH 611
Cdd:PHA03100 193 FTPLHYAVYNNNPEFVKYLLDLGANPnLVNKYGDTPLHIAILNNNKEIFKLLLNN 247
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
523-577 |
1.05e-08 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 52.28 E-value: 1.05e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 55742489 523 GWTCLHHAAAEGYTQTMKILLAANVKLlDEKNEDGNTALHIAAQAGHVSAVLLLL 577
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADI-NAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
457-511 |
1.64e-08 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 51.89 E-value: 1.64e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 55742489 457 SALHFAAEYGRINTCHRLLETLTDskmLNDWDEKGLTPLHLASRAGHAQVVDLLL 511
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGAD---INAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
421-633 |
1.73e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 58.08 E-value: 1.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 421 EGCTPLHYACKLGIHDSVKNMLGLNICLGQKSREKKSALHFAAEYGRINTCHRLLETltdSKMLND-WDEKGLTPLHLAS 499
Cdd:PHA02875 34 DGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDL---GKFADDvFYKDGMTPLHLAT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 500 RAGHAQVVDLLLRKGALFQ-SDYKGWTCLHHAAAEGYTQTMKILLAANVkLLDEKNEDGNTALHIAAQAGHVSAVLLLLD 578
Cdd:PHA02875 111 ILKKLDIMKLLIARGADPDiPNTDKFSPLHLAVMMGDIKGIELLIDHKA-CLDIEDCCGCTPLIIAMAKGDIAICKMLLD 189
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 55742489 579 RGAEIAL--NDADNSFLHEAVRNERREVVNATIEHErCDESMTSFKAKSRCVVLDII 633
Cdd:PHA02875 190 SGANIDYfgKNGCVAALCYAIENNKIDIVRLFIKRG-ADCNIMFMIEGEECTILDMI 245
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
211-515 |
2.24e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 58.15 E-value: 2.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 211 EMVLKIGEElgvsstlhINYLDKSKSTPLHLAVRGGNIEVIKLCILKGAKVEQHQSGKCTALHFACSQGSLEAVKIML-- 288
Cdd:PHA02876 162 EMLLEGGAD--------VNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIdn 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 289 -SSYN----------RTEDI------------VNIRDGANRTPLHratlfdhvelaeYLISKPNTLSLDLICLGKGAEID 345
Cdd:PHA02876 234 rSNINkndlsllkaiRNEDLetslllydagfsVNSIDDCKNTPLH------------HASQAPSLSRLVPKLLERGADVN 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 346 SIDCKGLSPL-LLASSCSAWKTVAYLLSIGADFKIKEKTGRNFLHfvilQPKGLKNLPETVLQSTAVKEMLSDEDVEGCT 424
Cdd:PHA02876 302 AKNIKGETPLyLMAKNGYDTENIRTLIMLGADVNAADRLYITPLH----QASTLDRNKDIVITLLELGANVNARDYCDKT 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 425 PLHYACKLGIHDSVKNMLGLNICLGQKSREKKSALHFAAeYGriNTCHRLLETLTD-SKMLNDWDEKGLTPLHLASRAG- 502
Cdd:PHA02876 378 PIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAL-CG--TNPYMSVKTLIDrGANVNSKNKDLSTPLHYACKKNc 454
|
330
....*....|...
gi 55742489 503 HAQVVDLLLRKGA 515
Cdd:PHA02876 455 KLDVIEMLLDNGA 467
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
436-636 |
3.05e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 57.28 E-value: 3.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 436 DSVKNMLGLNICLGQKSREKKSALHFAAEYGRINTCHRLLETLTDskmLNDWDEKGLTPLHLASRAGHAQVVDLLLRKGA 515
Cdd:PHA02874 105 DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGAD---VNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGA 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 516 LfqsdykgwtclhhaaaegytqtmkillaANVKlldekNEDGNTALHIAAQAGHVSAVLLLLDRGAEIaLNDADNSF--L 593
Cdd:PHA02874 182 Y----------------------------ANVK-----DNNGESPLHNAAEYGDYACIKLLIDHGNHI-MNKCKNGFtpL 227
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 55742489 594 HEAVRNERREVV----NATIEHERCDESMTSFKAKSRCVVLDIIEFL 636
Cdd:PHA02874 228 HNAIIHNRSAIEllinNASINDQDIDGSTPLHHAINPPCDIDIIDIL 274
|
|
| TRPV1 |
cd22196 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ... |
490-1010 |
3.68e-08 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411980 [Multi-domain] Cd Length: 649 Bit Score: 57.51 E-value: 3.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 490 KGLTPLHLASRAGHAQVVDLLLRKGA---------LFQSD------YKGWTCLHHAAAEGYTQTMKILL-----AANVKL 549
Cdd:cd22196 93 KGQTALHIAIERRNMHLVELLVQNGAdvharasgeFFKKKkggpgfYFGELPLSLAACTNQLDIVKFLLenphsPADISA 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 550 LDEKnedGNTALHIAAqaghvsavlllldrgaEIALNDADNSFLHEAVRNE---RREVVNATIEHERC--DESMTSFKAK 624
Cdd:cd22196 173 RDSM---GNTVLHALV----------------EVADNTPENTKFVTKMYNEiliLGAKIRPLLKLEEItnKKGLTPLKLA 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 625 SRCVVLDIieflpesFQHLLDQCITESDHDansqdyHIMYNF-QWLQAPIQLKKY----AKTDKTKAFQPLAALNAMVRY 699
Cdd:cd22196 234 AKTGKIGI-------FAYILGREIKEPECR------HLSRKFtEWAYGPVHSSLYdlssIDTYEKNSVLEIIAYSSETPN 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 700 NRLELLIHPLSrKYLEMKWTAYGSKVHFLNLAIYLLGLLPLTYLILNlRPSqdfskgNGTSVIMVPVSFSEqqYLISVCI 779
Cdd:cd22196 301 RHEMLLVEPLN-KLLQDKWDKFVKRIFYFNFFVYFIYMIIFTLAAYY-RPV------NKTPPFPIENTTGE--YLRLTGE 370
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 780 IMVIVMNVYSICKEVVQLAQQRVNY---FTD-FSNPADWSAAISALVFVVPMCCSVEatwqwEAGAYAILT---SWIGFL 852
Cdd:cd22196 371 IISVSGGVYFFFRGIQYFLQRRPSLkklIVDsYCEILFFVQSLFLLASTVLYFCGRN-----EYVAFMVISlalGWANVL 445
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 853 LYFQRFERIGIYVVMFNG-IVRTLVCIMVLFVFLLLAFGLAFYALMLHRPE-------------------FSSISLALAQ 912
Cdd:cd22196 446 YYTRGFQQMGIYSVMIQKmILRDICRFLFVYLVFLFGFSAALVTLIEDGPPkgdvntsqkecvcksgynsYNSLYSTCLE 525
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 913 TFVMTVGELNYQstFLNSYEeghmaFPAITYFVFVFFVLLMPILLMNLMIGL---AVGDIAEVQRNA-ELKRIAMQIDlh 988
Cdd:cd22196 526 LFKFTIGMGDLE--FTENYK-----FKEVFIFLLISYVILTYILLLNMLIALmgeTVSKIAQESKNIwKLQRAITILD-- 596
|
570 580
....*....|....*....|..
gi 55742489 989 taLEEKLPYWFLKRVDKPSTVV 1010
Cdd:cd22196 597 --LEKSLLRCLRDRFRSGKSVL 616
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
448-964 |
1.50e-07 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 55.86 E-value: 1.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 448 LGQKSREKKSALHFAAE--YGRINTCHRLLET----LTDSKMLNDWD----EKGLTPLHLASRAGHAQVVDLLLRKGA-- 515
Cdd:TIGR00870 75 LSCRGAVGDTLLHAISLeyVDAVEAILLHLLAafrkSGPLELANDQYtsefTPGITALHLAAHRQNYEIVKLLLERGAsv 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 516 -------LFQSDyKGWTCLHH-------AAAEGYTQTMKILL--AANVKLLDEKnedGNTALHIAAqaghvsavlllldr 579
Cdd:TIGR00870 155 paracgdFFVKS-QGVDSFYHgesplnaAACLGSPSIVALLSedPADILTADSL---GNTLLHLLV-------------- 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 580 gaEIALNDADNSFLHEAVRNErrevvnATIEHERCDESM-----------TSFKaksrcvvLDIIEFLPESFQHLLdqci 648
Cdd:TIGR00870 217 --MENEFKAEYEELSCQMYNF------ALSLLDKLRDSKelevilnhqglTPLK-------LAAKEGRIVLFRLKL---- 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 649 tesdhdanSQDYHIMYNFQWLQAPIQLKKYAKT------DKTKAFQPLAA--LNAMVRYNRLELLIHPLSRkYLEMKWTA 720
Cdd:TIGR00870 278 --------AIKYKQKKFVAWPNGQQLLSLYWLEeldgwrRKQSVLELIVVfvIGLKFPELSDMYLIAPLSR-LGQFKWKP 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 721 YGSKVHFLNLAIYllgllpltylILNL---------RPSQDFSKGNGTSVIMVPVSFSE-QQYLISVCIIMVIVMNVYSI 790
Cdd:TIGR00870 349 FIKFIFHSASYLY----------FLYLiiftsvayyRPTRTDLRVTGLQQTPLEMLIVTwVDGLRLGEEKLIWLGGIFEY 418
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 791 CKEVVQLAQQRVN--YFTDFS-NPADWSAAISALVFVVPMCCSVEATwQWEAGAYAI--LTSWIgFLLYFQR-FERIGIY 864
Cdd:TIGR00870 419 IHQLWNILDFGMNsfYLATFLdRPFAILFVTQAFLVLREHWLRFDPT-LIEEALFAFalVLSWL-NLLYIFRgNQHLGPL 496
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 865 VVMFNG-IVRTLVCIMVLFVFLLLAFGLAFYALM-----LHRPEFSSISLALAQ-------TFVMTVGELnYQSTF-LNS 930
Cdd:TIGR00870 497 QIMIGRmILGDILRFLFIYAVVLFGFACGLNQLYqyydeLKLNECSNPHARSCEkqgnaysTLFETSQEL-FWAIIgLGD 575
|
570 580 590
....*....|....*....|....*....|....*
gi 55742489 931 YEEG-HMAFPAITYFVFVFFVLLMPILLMNLMIGL 964
Cdd:TIGR00870 576 LLANeHKFTEFVGLLLFGAYNVIMYILLLNMLIAM 610
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
237-483 |
1.62e-07 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 55.00 E-value: 1.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 237 TPLHLAVRGGNIEVIKLCILKGAKVEQHQSGKCTALHFACSQGSLEAVKIMLSSYNRTEDIVnIRDGanRTPLHRATLFD 316
Cdd:PHA02875 37 SPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVF-YKDG--MTPLHLATILK 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 317 HVELAEYLISK------PNT----------LSLDL----ICLGKGAEIDSIDCKGLSPLLLASSCSAWKTVAYLLSIGAD 376
Cdd:PHA02875 114 KLDIMKLLIARgadpdiPNTdkfsplhlavMMGDIkgieLLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGAN 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 377 FKIKEKTGRNFLHFVILQpkglKNLPETV---LQSTAVKEMLSDEDVEGCTPLHYACKLGIHDSVK--NMLGLNICLGQK 451
Cdd:PHA02875 194 IDYFGKNGCVAALCYAIE----NNKIDIVrlfIKRGADCNIMFMIEGEECTILDMICNMCTNLESEaiDALIADIAIRIH 269
|
250 260 270
....*....|....*....|....*....|..
gi 55742489 452 SREKKSALHFAAEYGRINTCHRLLETLTDSKM 483
Cdd:PHA02875 270 KKTIRRDEGFKNNMSTIEDKEEFKDVFEKCII 301
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
474-604 |
1.95e-07 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 55.26 E-value: 1.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 474 LLETLTDSKMLND-WDEKGLTPLHLASRAGHAQVVDLLLRKG----------------ALFQSDYKGWTCLHH------- 529
Cdd:PLN03192 540 LLEELLKAKLDPDiGDSKGRTPLHIAASKGYEDCVLVLLKHAcnvhirdangntalwnAISAKHHKIFRILYHfasisdp 619
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 530 ---------AAAEGYTQTMKILLAANVKLlDEKNEDGNTALHIAAQAGHVSAVLLLLDRGAEIALNDADNSFLHEAVRN- 599
Cdd:PLN03192 620 haagdllctAAKRNDLTAMKELLKQGLNV-DSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTDDDFSPTELREl 698
|
....*.
gi 55742489 600 -ERREV 604
Cdd:PLN03192 699 lQKREL 704
|
|
| TRPV2 |
cd22197 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2; TRPV2 is closely ... |
478-1002 |
2.58e-07 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2; TRPV2 is closely related to TRPV1, sharing high sequence identity (>50%), but TRPV2 shows a higher temperature threshold and sensitivity for activation than TRPV1. TRPV2 can be stimulated by ligands or lipids, and is involved in osmosensation and mechanosensation. TRPV2 is expressed in both neuronal and non-neuronal tissues, and it has been implicated in diverse physiological and pathophysiological processes, including cardiac-structure maintenance, innate immunity, and cancer. TRPV2 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411981 [Multi-domain] Cd Length: 640 Bit Score: 54.86 E-value: 2.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 478 LTDSKMLNDWdEKGLTPLHLASRAGHAQVVDLLLRKGA---------LFQSD-----YKGWTCLHHAAAEGYTQTMKILL 543
Cdd:cd22197 82 LVNAQCTDEY-YRGHSALHIAIEKRSLQCVKLLVENGAdvharacgrFFQKKqgtcfYFGELPLSLAACTKQWDVVNYLL 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 544 --AANVKLLDEKNEDGNTALHiaaqaghvsAVLLLLDrgaeialNDADNSFL-----HEAVRNERREVVNATIEHERCDE 616
Cdd:cd22197 161 enPHQPASLQAQDSLGNTVLH---------ALVMIAD-------NSPENSALvikmyDGLLQAGARLCPTVQLEEISNHE 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 617 SMTSFKAKSRCVVLDIieflpesFQHLLDQCITESDHdansqdyHIMYNF-QWLQAPIQLKKY--AKTDKTKAFQPLAAL 693
Cdd:cd22197 225 GLTPLKLAAKEGKIEI-------FRHILQREFSGPYQ-------HLSRKFtEWCYGPVRVSLYdlSSVDSWEKNSVLEII 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 694 ----NAMVRYNRLELliHPLSrKYLEMKWTAYGSKVhFLNLAIYLLGLLPLTYLILNlRPSQDFSKgngtsviMVPVSFS 769
Cdd:cd22197 291 afhsKSPNRHRMVVL--EPLN-KLLQEKWDRLVSRF-YFNFLCYLVYMFIFTVVAYH-QPLLDQPP-------IPPLKAT 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 770 EQQYLISVCIIMVIVMNVYSICKEVVQLAQQRVNYFTDFSNP-ADWSAAISALVFVVP-MCCSVEATWQWEAGAYAILTS 847
Cdd:cd22197 359 AGGSMLLLGHILILLGGIYLLLGQLWYFWRRRLFIWISFMDSyFEILFLLQALLTVLSqVLYFMGSEWYLPLLVFSLVLG 438
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 848 WIGFLLYFQRFERIGIYVVMFNG-IVRTLvcIMVLFVFLLLAFGLAFYALMLHR-------------------------- 900
Cdd:cd22197 439 WLNLLYYTRGFQHTGIYSVMIQKvILRDL--LRFLLVYLVFLFGFAVALVSLSReapspkapednnstvteqptvgqeee 516
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 901 -PEFSSISLALAQTFVMTVG--ELNYQStflnsyeegHMAFPAITYFVFVFFVLLMPILLMNLMIGLAVGDIAEVQRNA- 976
Cdd:cd22197 517 pAPYRSILDASLELFKFTIGmgELAFQE---------QLRFRGVVLLLLLAYVLLTYVLLLNMLIALMSETVNHVADNSw 587
|
570 580
....*....|....*....|....*....
gi 55742489 977 ---ELKRIAMQIDLhtaleEKLPYWFLKR 1002
Cdd:cd22197 588 siwKLQKAISVLEM-----ENGYWWCRRK 611
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
102-442 |
2.60e-07 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 55.07 E-value: 2.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 102 VEQDQQQSCAVLLDLGADPNILNNALMGPLHLAVTKQYNHLAEVLLSCDkTNSNLEGDLGNTPVMLACSNNNCQALQILI 181
Cdd:PHA02876 153 IQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYG-ADVNIIALDDLSVLECAVDSKNIDTIKAII 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 182 KRGAKMCiQNKLghypihTVAFAGAKEAMEMVLkigeeLGVSSTLHINYLDKSKSTPLHLAVRGGNI-EVIKLCILKGAK 260
Cdd:PHA02876 232 DNRSNIN-KNDL------SLLKAIRNEDLETSL-----LLYDAGFSVNSIDDCKNTPLHHASQAPSLsRLVPKLLERGAD 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 261 VEQHQSGKCTALHFACSQG-SLEAVKIMLSsynRTEDiVNIRDGANRTPLHRATLFDHvelaeyliSKPNTLSLdlicLG 339
Cdd:PHA02876 300 VNAKNIKGETPLYLMAKNGyDTENIRTLIM---LGAD-VNAADRLYITPLHQASTLDR--------NKDIVITL----LE 363
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 340 KGAEIDSIDCKGLSPLLLASSCSAWKTVAYLLSIGADFK-IKEKTGrNFLHFVILQPKGLKNLPETVLQSTAVKEmlSDE 418
Cdd:PHA02876 364 LGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEaLSQKIG-TALHFALCGTNPYMSVKTLIDRGANVNS--KNK 440
|
330 340
....*....|....*....|....
gi 55742489 419 DVEgcTPLHYACKLGIHDSVKNML 442
Cdd:PHA02876 441 DLS--TPLHYACKKNCKLDVIEML 462
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
52-199 |
5.78e-07 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 53.43 E-value: 5.78e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 52 LSLRDENGASLLHYASAGGNLDIIRLIVSiVGPEVlNVQDEQGRTPLHWAVEQDQQQSCAVLLDLGADPNILNNALMGPL 131
Cdd:PHA02874 117 VNIKDAELKTFLHYAIKKGDLESIKMLFE-YGADV-NIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPL 194
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 55742489 132 HLAVtkQYNHLAEVLLSCDKTNS-NLEGDLGNTPVMLACSNNNcQALQILIKrGAKMCIQNKLGHYPIH 199
Cdd:PHA02874 195 HNAA--EYGDYACIKLLIDHGNHiMNKCKNGFTPLHNAIIHNR-SAIELLIN-NASINDQDIDGSTPLH 259
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
33-309 |
6.16e-07 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 53.53 E-value: 6.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 33 AFKGKASAIDRLIQKGPEhLSLRDENGASLLHYASAGGNLDIIRLIV---------------SIVGPEV----------- 86
Cdd:PHA02876 186 AERGNAKMVNLLLSYGAD-VNIIALDDLSVLECAVDSKNIDTIKAIIdnrsninkndlsllkAIRNEDLetslllydagf 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 87 -LNVQDEQGRTPLHWAVEQDQ-QQSCAVLLDLGADPNILNNALMGPLHLAVTKQYNHLAEVLLSCDKTNSNLEGDLGNTP 164
Cdd:PHA02876 265 sVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYDTENIRTLIMLGADVNAADRLYITP 344
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 165 VMLACS-NNNCQALQILIKRGAKMCIQNKLGHYPIHTVAFAGAKEAMEMVLKIGEElgvsstlhINYLDKSKSTPLHLAV 243
Cdd:PHA02876 345 LHQASTlDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGAD--------IEALSQKIGTALHFAL 416
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 55742489 244 RGGN-IEVIKLCILKGAKVEQHQSGKCTALHFACSQGSLEAVKIMLSSYNRTEDIVNIRdgaNRTPL 309
Cdd:PHA02876 417 CGTNpYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNCKLDVIEMLLDNGADVNAINIQ---NQYPL 480
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
35-200 |
1.01e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 52.66 E-value: 1.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 35 KGKASAIDRLIQKGPEhLSLRDENGASLLHYASAGGNLDIIRLIVSivGPEVLNVQDEQGRTPLHWAVEQDQQQSCAVLL 114
Cdd:PHA02874 134 KGDLESIKMLFEYGAD-VNIEDDNGCYPIHIAIKHNFFDIIKLLLE--KGAYANVKDNNGESPLHNAAEYGDYACIKLLI 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 115 DLGAdpNILNNALMG--PLHLAVTkqYNHLAEVLLSCDKTNSNLEGDlGNTPVMLA----CSNNncqALQILIKRGAKMC 188
Cdd:PHA02874 211 DHGN--HIMNKCKNGftPLHNAII--HNRSAIELLINNASINDQDID-GSTPLHHAinppCDID---IIDILLYHKADIS 282
|
170
....*....|..
gi 55742489 189 IQNKLGHYPIHT 200
Cdd:PHA02874 283 IKDNKGENPIDT 294
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
162-358 |
1.18e-06 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 52.71 E-value: 1.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 162 NTPVMLACSNNNCQALQILIK-RGAKMCIQNKLGHYPIHTVAFAGAKEAMEMVLKIGEEL---GVSSTLhinYLDKsksT 237
Cdd:cd22192 18 ESPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPELvnePMTSDL---YQGE---T 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 238 PLHLAVRGGNIEVIKLCILKGAKV----------EQHQSGKC----TALHFACSQGSLEAVKIMLssyNRTEDIVNiRDG 303
Cdd:cd22192 92 ALHIAVVNQNLNLVRELIARGADVvspratgtffRPGPKNLIyygeHPLSFAACVGNEEIVRLLI---EHGADIRA-QDS 167
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 55742489 304 ANRTPLHratlfdhvelaeYLISKPNTLS----LDLIcLGKGAEIDSI------DCKGLSPLLLA 358
Cdd:cd22192 168 LGNTVLH------------ILVLQPNKTFacqmYDLI-LSYDKEDDLQpldlvpNNQGLTPFKLA 219
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
130-448 |
1.24e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 52.57 E-value: 1.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 130 PLHLAVTKQYNHLAEVLLSCDkTNSNLEGDLGNTPVMLACSNNNCQALQILIKRGAKMCIQNKLghYPIHTVAFAGAKEA 209
Cdd:PHA02878 40 PLHQAVEARNLDVVKSLLTRG-HNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTL--VAIKDAFNNRNVEI 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 210 MEMVLKigEELGVSSTLHINYLDKSKSTPLHLAvrggniEVIKLCILKGAKVEQHQSGK-CTALHFACSQGSLEAVKIML 288
Cdd:PHA02878 117 FKIILT--NRYKNIQTIDLVYIDKKSKDDIIEA------EITKLLLSYGADINMKDRHKgNTALHYATENKDQRLTELLL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 289 SSYNRtediVNIRDGANRTPLHRAtlfdhvelaeylISKPNTLSLDlICLGKGAEIDSIDCKGLSPLLLA-SSCSAWKTV 367
Cdd:PHA02878 189 SYGAN----VNIPDKTNNSPLHHA------------VKHYNKPIVH-ILLENGASTDARDKCGNTPLHISvGYCKDYDIL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 368 AYLLSIGADFKIKEkTGRNF--LHFVILQPKGLKNLPETVLQSTAVkemlsdeDVEGCTPLHYACKLGIHDSVKNMLGLN 445
Cdd:PHA02878 252 KLLLEHGVDVNAKS-YILGLtaLHSSIKSERKLKLLLEYGADINSL-------NSYKLTPLSSAVKQYLCINIGRILISN 323
|
...
gi 55742489 446 ICL 448
Cdd:PHA02878 324 ICL 326
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
281-597 |
1.76e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 52.37 E-value: 1.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 281 LEAVKIMLSSYNRTEDIVNI-RDGANRTPLHRATLFDHVELAEYLISK--PNTLSLDLICLGKGAEIDSIDCKGLSPLLL 357
Cdd:PHA02876 105 IKYASIILNKHKLDEACIHIlKEAISGNDIHYDKINESIEYMKLIKERiqQDELLIAEMLLEGGADVNAKDIYCITPIHY 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 358 ASSCSAWKTVAYLLSIGADFKIKEKTGRNFLHFVIlQPKGLKNLPETVLQSTAVKE-------MLSDEDVEgctplhyaC 430
Cdd:PHA02876 185 AAERGNAKMVNLLLSYGADVNIIALDDLSVLECAV-DSKNIDTIKAIIDNRSNINKndlsllkAIRNEDLE--------T 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 431 KLGIHDSVKNMLGLNIClgqksreKKSALHFAAEYGRINT-CHRLLETLTDskmLNDWDEKGLTPLHLASRAGH--AQVV 507
Cdd:PHA02876 256 SLLLYDAGFSVNSIDDC-------KNTPLHHASQAPSLSRlVPKLLERGAD---VNAKNIKGETPLYLMAKNGYdtENIR 325
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 508 DLLLRKGALFQSDYKGWTCLHHAAA-EGYTQTMKILL--AANVKLLDEKNEdgnTALHIAAQAGHVSAVLLLLDRGAEI- 583
Cdd:PHA02876 326 TLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLelGANVNARDYCDK---TPIHYAAVRNNVVIINTLLDYGADIe 402
|
330
....*....|....
gi 55742489 584 ALNDADNSFLHEAV 597
Cdd:PHA02876 403 ALSQKIGTALHFAL 416
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
270-325 |
2.17e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 45.73 E-value: 2.17e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 55742489 270 TALHFACSQGSLEAVKIMLSSYNRtediVNIRDGANRTPLHRATLFDHVELAEYLI 325
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGAD----INAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
28-135 |
3.83e-06 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 50.79 E-value: 3.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 28 DVFELAFKGKASAIDRLIQKGPEHLSlRDENGASLLHYASAGG---NLDIIRLIVSIVGpevLNVQDEQGRTPLHWAVEQ 104
Cdd:PHA03095 192 HHHLQSFKPRARIVRELIRAGCDPAA-TDMLGNTPLHSMATGSsckRSLVLPLLIAGIS---INARNRYGQTPLHYAAVF 267
|
90 100 110
....*....|....*....|....*....|.
gi 55742489 105 DQQQSCAVLLDLGADPNILNNALMGPLHLAV 135
Cdd:PHA03095 268 NNPRACRRLIALGADINAVSSDGNTPLSLMV 298
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
67-157 |
9.05e-06 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 49.90 E-value: 9.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 67 SAGGNLDIIRLIVSivGPEVLNVQDEQGRTPLHWAVEQDQQQSCAVLLDLGADPNILNNALMGPLHLAVTKQYNHLAEVL 146
Cdd:PTZ00322 90 AASGDAVGARILLT--GGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
|
90
....*....|.
gi 55742489 147 LSCDKTNSNLE 157
Cdd:PTZ00322 168 SRHSQCHFELG 178
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
236-288 |
1.08e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 43.80 E-value: 1.08e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 55742489 236 STPLHLAVRGGNIEVIKLCILKGAKVEQHQSGKCTALHFACSQGSLEAVKIML 288
Cdd:pfam13637 2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02736 |
PHA02736 |
Viral ankyrin protein; Provisional |
55-186 |
1.51e-05 |
|
Viral ankyrin protein; Provisional
Pssm-ID: 165103 [Multi-domain] Cd Length: 154 Bit Score: 46.41 E-value: 1.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 55 RDENGASLLHY-ASAGGNLDII--RLIVSIVGPEVLNVQDEQGRTPLHWAVEQDQ---QQSCAVLLDLGADPN----ILN 124
Cdd:PHA02736 13 PDIEGENILHYlCRNGGVTDLLafKNAISDENRYLVLEYNRHGKQCVHIVSNPDKadpQEKLKLLMEWGADINgkerVFG 92
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 55742489 125 NAlmgPLHLAVTKQYNHLAEVLlsCDKTNSNLE--GDLGNTPVMLACSNNNCQALQILIKRGAK 186
Cdd:PHA02736 93 NT---PLHIAVYTQNYELATWL--CNQPGVNMEilNYAFKTPYYVACERHDAKMMNILRAKGAQ 151
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
355-446 |
1.74e-05 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 44.34 E-value: 1.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 355 LLLASSCSAWKTVAYLLSIGADFKIKEKTGRNFLHFVILqpkglKNLPETVlqSTAVKEMLSDEDVEGCTPLHYACKLGI 434
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAK-----NGHLEIV--KLLLEHADVNLKDNGRTALHYAARSGH 73
|
90
....*....|..
gi 55742489 435 HDSVKNMLGLNI 446
Cdd:pfam12796 74 LEIVKLLLEKGA 85
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
32-220 |
2.03e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 48.91 E-value: 2.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 32 LAFKGKASAIDRLIQKGPEH---LSLRDENGASLLH-YASAGGNLDIIRLIVSIvGPEVlNVQDEQGRTPLHWAVEQDQQ 107
Cdd:PHA02876 277 LHHASQAPSLSRLVPKLLERgadVNAKNIKGETPLYlMAKNGYDTENIRTLIML-GADV-NAADRLYITPLHQASTLDRN 354
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 108 QSCAV-LLDLGADPNILNNALMGPLHLAVTKQYNHLAEVLLSCDKTNSNLEGDLGNTPVMLACSNNNCQALQILIKRGAK 186
Cdd:PHA02876 355 KDIVItLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPYMSVKTLIDRGAN 434
|
170 180 190
....*....|....*....|....*....|....*
gi 55742489 187 MCIQNKLGHYPIHTVAFAGAK-EAMEMVLKIGEEL 220
Cdd:PHA02876 435 VNSKNKDLSTPLHYACKKNCKlDVIEMLLDNGADV 469
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
557-605 |
2.03e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 43.03 E-value: 2.03e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 55742489 557 GNTALHIAAQAGHVSAVLLLLDRGAEI-ALNDADNSFLHEAVRNERREVV 605
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADInAVDGNGETALHFAASNGNVEVL 50
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
491-543 |
2.43e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 42.65 E-value: 2.43e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 55742489 491 GLTPLHLASRAGHAQVVDLLLRKGA-LFQSDYKGWTCLHHAAAEGYTQTMKILL 543
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGAdINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
459-638 |
2.45e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 48.34 E-value: 2.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 459 LHFAAEYGRINTCHRLLETLTDskmLNDWDEKGLTPLHLASRAGHAQVVDLLLR---KGALFQSDYKGWTCLHHAAAEGY 535
Cdd:PHA02878 41 LHQAVEARNLDVVKSLLTRGHN---VNQPDHRDLTPLHIICKEPNKLGMKEMIRsinKCSVFYTLVAIKDAFNNRNVEIF 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 536 -----------------------------TQTMKILLA--ANVKLLDEknEDGNTALHIAAQAGHVSAVLLLLDRGAEI- 583
Cdd:PHA02878 118 kiiltnrykniqtidlvyidkkskddiieAEITKLLLSygADINMKDR--HKGNTALHYATENKDQRLTELLLSYGANVn 195
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 55742489 584 ALNDADNSFLHEAVRNERREVVNATIEHERCDESMTSFK------AKSRCVVLDIIEFLPE 638
Cdd:PHA02878 196 IPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGntplhiSVGYCKDYDILKLLLE 256
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
44-101 |
3.67e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 42.33 E-value: 3.67e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 55742489 44 LIQKGPEHLSLRDENGASLLHYASAGGNLDIIRLIvsIVGPEVLNVQDEQGRTPLHWA 101
Cdd:pfam13857 1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVL--LAYGVDLNLKDEEGLTALDLA 56
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
94-250 |
8.03e-05 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 46.54 E-value: 8.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 94 GRTPLHWAVEQDQQQSCAVLLDlgADPNILNNALMG-------PLHLAVTKQYNHLAEVLLS--CDKTNSNLEGDL---- 160
Cdd:cd22192 51 GETALHVAALYDNLEAAVVLME--AAPELVNEPMTSdlyqgetALHIAVVNQNLNLVRELIArgADVVSPRATGTFfrpg 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 161 -------GNTPVMLACSNNNCQALQILIKRGAKMCIQNKLGHYPIHTVAFAG----AKEAMEMVLKIGEELGVSSTLHIn 229
Cdd:cd22192 129 pknliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPnktfACQMYDLILSYDKEDDLQPLDLV- 207
|
170 180
....*....|....*....|.
gi 55742489 230 yLDKSKSTPLHLAVRGGNIEV 250
Cdd:cd22192 208 -PNNQGLTPFKLAAKEGNIVM 227
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
93-125 |
1.42e-04 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 39.97 E-value: 1.42e-04
10 20 30
....*....|....*....|....*....|....
gi 55742489 93 QGRTPLHWAVEQDQQQSCA-VLLDLGADPNILNN 125
Cdd:pfam00023 1 DGNTPLHLAAGRRGNLEIVkLLLSKGADVNARDK 34
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
556-587 |
1.58e-04 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 39.97 E-value: 1.58e-04
10 20 30
....*....|....*....|....*....|...
gi 55742489 556 DGNTALHIAA-QAGHVSAVLLLLDRGAEIALND 587
Cdd:pfam00023 1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
|
|
| PHA02791 |
PHA02791 |
ankyrin-like protein; Provisional |
91-194 |
1.90e-04 |
|
ankyrin-like protein; Provisional
Pssm-ID: 165154 [Multi-domain] Cd Length: 284 Bit Score: 44.65 E-value: 1.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 91 DEQGRTPLHWAVEQDQQQSCAVLLDLGADPNILNNALmgPLHLAVTKQYNHLAEVLLSCDKTNSNLEgDLGNTPVMLACS 170
Cdd:PHA02791 27 DVHGHSALYYAIADNNVRLVCTLLNAGALKNLLENEF--PLHQAATLEDTKIVKILLFSGMDDSQFD-DKGNTALYYAVD 103
|
90 100
....*....|....*....|....
gi 55742489 171 NNNCQALQILIKRGAKMCIQNKLG 194
Cdd:PHA02791 104 SGNMQTVKLFVKKNWRLMFYGKTG 127
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
561-636 |
1.95e-04 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 41.25 E-value: 1.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 561 LHIAAQAGHVSAVLLLLDRGAEIALNDADNSF-LHEAVRNERREVVNATIEHERCDESMTSFKAKSRCVV---LDIIEFL 636
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTaLHLAAKNGHLEIVKLLLEHADVNLKDNGRTALHYAARsghLEIVKLL 80
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
83-134 |
2.55e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 40.02 E-value: 2.55e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 55742489 83 GPEVLNVQDEQGRTPLHWAVEQDQQQSCAVLLDLGADPNILNNALMGPLHLA 134
Cdd:pfam13857 5 GPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
94-147 |
2.98e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 39.57 E-value: 2.98e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 55742489 94 GRTPLHWAVEQDQQQSCAVLLDLGADPNILNNALMGPLHLAVTKQYNHLAEVLL 147
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
35-185 |
2.99e-04 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 44.60 E-value: 2.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 35 KGKASAIDRLIQKGPEHLSLRDENGASLLHYASAGGNLDIIRLIVSI-VGPEVLNVQDEqgrTPLHWAVEQDQQQSCAVL 113
Cdd:PHA02875 78 EGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARgADPDIPNTDKF---SPLHLAVMMGDIKGIELL 154
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 55742489 114 LDLGADPNILNNALMGPLHLAVTKQYNHLAEVLLScDKTNSNLEGDLGNTPVM-LACSNNNCQALQILIKRGA 185
Cdd:PHA02875 155 IDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLD-SGANIDYFGKNGCVAALcYAIENNKIDIVRLFIKRGA 226
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
484-530 |
3.29e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 39.64 E-value: 3.29e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 55742489 484 LNDWDEKGLTPLHLASRAGHAQVVDLLLRKGA-LFQSDYKGWTCLHHA 530
Cdd:pfam13857 9 LNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVdLNLKDEEGLTALDLA 56
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
556-583 |
5.11e-04 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 38.34 E-value: 5.11e-04
10 20
....*....|....*....|....*...
gi 55742489 556 DGNTALHIAAQAGHVSAVLLLLDRGAEI 583
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
490-515 |
9.63e-04 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 37.65 E-value: 9.63e-04
10 20
....*....|....*....|....*..
gi 55742489 490 KGLTPLHLAS-RAGHAQVVDLLLRKGA 515
Cdd:pfam00023 1 DGNTPLHLAAgRRGNLEIVKLLLSKGA 27
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
542-591 |
1.21e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 38.10 E-value: 1.21e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 55742489 542 LLAANVKLLDEKNEDGNTALHIAAQAGHVSAVLLLLDRGAEIALNDADNS 591
Cdd:pfam13857 1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGL 50
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
225-395 |
1.22e-03 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 42.69 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 225 TLHINYLDKSKSTPLHLAVRGGNIEVIKLcILKGAKVEQHQSGKC--TALHFACSQGSLEAVKIMLSSYNR------TED 296
Cdd:cd22192 7 ELHLLQQKRISESPLLLAAKENDVQAIKK-LLKCPSCDLFQRGALgeTALHVAALYDNLEAAVVLMEAAPElvnepmTSD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 297 IVnirdgANRTPLHRATLFDHVELAEYLISKpntlsldliclgkGAEIDS-----------IDCK---GLSPLLLASSCS 362
Cdd:cd22192 86 LY-----QGETALHIAVVNQNLNLVRELIAR-------------GADVVSpratgtffrpgPKNLiyyGEHPLSFAACVG 147
|
170 180 190
....*....|....*....|....*....|...
gi 55742489 363 AWKTVAYLLSIGADFKIKEKTGRNFLHFVILQP 395
Cdd:cd22192 148 NEEIVRLLIEHGADIRAQDSLGNTVLHILVLQP 180
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
556-583 |
2.94e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 36.08 E-value: 2.94e-03
10 20
....*....|....*....|....*...
gi 55742489 556 DGNTALHIAAQAGHVSAVLLLLDRGAEI 583
Cdd:pfam13606 1 DGNTPLHLAARNGRLEIVKLLLENGADI 28
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
61-102 |
3.49e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 36.87 E-value: 3.49e-03
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 55742489 61 SLLHYASAGGNLDIIRLIVSiVGPEVlNVQDEQGRTPLHWAV 102
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLE-KGADI-NAVDGNGETALHFAA 42
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
490-515 |
3.87e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 36.03 E-value: 3.87e-03
10 20
....*....|....*....|....*.
gi 55742489 490 KGLTPLHLASRAGHAQVVDLLLRKGA 515
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGA 26
|
|
| PHA02946 |
PHA02946 |
ankyin-like protein; Provisional |
88-300 |
4.57e-03 |
|
ankyin-like protein; Provisional
Pssm-ID: 165256 [Multi-domain] Cd Length: 446 Bit Score: 40.81 E-value: 4.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 88 NVQDEQGRTPLHWAVEQDQQQSCAVLLDLGADPNILNNALMGPLHL------AVTKQYNHLAEVllsCDKTNSNLEGDlG 161
Cdd:PHA02946 66 NETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYlsgtddEVIERINLLVQY---GAKINNSVDEE-G 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 162 NTPvMLACSNNNCQALQILIKRGAKMCIQNKLGHYPIHTVAFAGAKEAMEMVLKIgeELGVSSTLHinylDKSKSTPLHL 241
Cdd:PHA02946 142 CGP-LLACTDPSERVFKKIMSIGFEARIVDKFGKNHIHRHLMSDNPKASTISWMM--KLGISPSKP----DHDGNTPLHI 214
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 55742489 242 AVRG--GNIEVIKLCILKGAKVEQHQSGKCTALHFACSQGSLEAVKIMLSSYNR-TEDIVNI 300
Cdd:PHA02946 215 VCSKtvKNVDIINLLLPSTDVNKQNKFGDSPLTLLIKTLSPAHLINKLLSTSNViTDQTVNI 276
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
29-77 |
6.18e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 36.10 E-value: 6.18e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 55742489 29 VFELAFKGKASAIDRLIQKGPEhLSLRDENGASLLHYASAGGNLDIIRL 77
Cdd:pfam13637 5 LHAAAASGHLELLRLLLEKGAD-INAVDGNGETALHFAASNGNVEVLKL 52
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
237-262 |
6.98e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 35.26 E-value: 6.98e-03
10 20
....*....|....*....|....*.
gi 55742489 237 TPLHLAVRGGNIEVIKLCILKGAKVE 262
Cdd:smart00248 4 TPLHLAAENGNLEVVKLLLDKGADIN 29
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
41-149 |
1.00e-02 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 39.65 E-value: 1.00e-02
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55742489 41 IDRLIQKGpEHLSLRDENGASLLHYASAGGNLDIIRLivsivgpevlnvqdeqgrtplhwaveqdqqqscavLLDLGADP 120
Cdd:PHA03100 175 VNYLLSYG-VPINIKDVYGFTPLHYAVYNNNPEFVKY-----------------------------------LLDLGANP 218
|
90 100
....*....|....*....|....*....
gi 55742489 121 NILNNALMGPLHLAVTKQYNHLAEVLLSC 149
Cdd:PHA03100 219 NLVNKYGDTPLHIAILNNNKEIFKLLLNN 247
|
|
| |
