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Conserved domains on  [gi|54400468|ref|NP_001005983|]
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transmembrane protein 144b precursor [Danio rerio]

Protein Classification

L-rhamnose-proton symporter family protein( domain architecture ID 139974)

L-rhamnose-proton symporter family protein such as Escherichia coli RhaT, which is involved in uptake of L-rhamnose across the cytoplasmic membrane with the concomitant transport of protons into the cell

Gene Ontology:  GO:0015293|GO:0015144
PubMed:  1551902
TCDB:  2.A.7.6

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhaT super family cl19288
L-rhamnose-proton symport protein (RhaT); This family consists of several bacterial ...
 42-379 4.23e-100

L-rhamnose-proton symport protein (RhaT); This family consists of several bacterial L-rhamnose-proton symport protein (RhaT) sequences.


The actual alignment was detected with superfamily member pfam07857:

Pssm-ID: 302813  Cd Length: 333  Bit Score: 300.12  E-value: 4.23e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400468    42 TYGYVTCAFAVLLYGSYFVPMKRIETGDGMFFQWICASGIWFVGLVVDTLFHPSKAHPAAMLGGALWATGHVSAVPVVKF 121
Cdd:pfam07857   1 IVGYVACLVSSVTFGSMFVPLKRFHSGDGFFVQWIMSLAILLVGLIVYATLGFPKFEPLAMLGGMLWATGNAFAVPIMNG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400468   122 IGLGLGILLWGSSALLIGWASSRFGWFGLHPEEVSKPLLNYCGAGLCPLSAIIFFFVKS-DGHQRTSTEFMPLLIDdrrl 200
Cdd:pfam07857  81 IGLGVGILIWNTVNCLVGWAVTRFGLFGIPAQVPKSPFLNYIGIVLVVVGGFIFLFIKHvPKENETESDTTPLEME---- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400468   201 DPDSISPSDSWVDTISPKS--KRVFGCILAVFSGVLYGSAFVPVFYMKlhatNNSSMFIGSSQNEIDYCFAHYSGIFLTS 278
Cdd:pfam07857 157 HKKSLEQDLSSDDGLVKKSctRRIVCILLAIVSGFLYGSTFVPIIYIK----DNPPIYPGAPQDGLDYVFSHYTGIFLTS 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400468   279 TVYFLAYCAVMKNRPRIYPRAILPGFSSGLMWGLATYSWLMANYYLGAVITFPITNAGYSLVAALWGSVVFKEVKGIGNL 358
Cdd:pfam07857 233 TVYFFAYSIVKKNNPYVPSELVLPSIGSGILWAIAMTSWFVANQKLSQVVSYPIISRAPGLIAAAWSVFYFKEIQGKRNY 312

                         330       340
                  ....*....|....*....|.
gi 54400468   359 LLFALATCVVLAGSFLTAYSK 379
Cdd:pfam07857 313 ILLGIASAITLIGAIMVALSK 333
 
Name Accession Description Interval E-value
TMEM144 pfam07857
Transmembrane family, TMEM144 of transporters; Members of this family fall in to the drug ...
 42-379 4.23e-100

Transmembrane family, TMEM144 of transporters; Members of this family fall in to the drug/metabolite transporter (dmt) superfamily. They carry 10xTM domains arranged as 5+5. Although these two sets may originally have arisen by gene-duplication the divergence now is such that the two halves are no longer homologous.


Pssm-ID: 285141  Cd Length: 333  Bit Score: 300.12  E-value: 4.23e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400468    42 TYGYVTCAFAVLLYGSYFVPMKRIETGDGMFFQWICASGIWFVGLVVDTLFHPSKAHPAAMLGGALWATGHVSAVPVVKF 121
Cdd:pfam07857   1 IVGYVACLVSSVTFGSMFVPLKRFHSGDGFFVQWIMSLAILLVGLIVYATLGFPKFEPLAMLGGMLWATGNAFAVPIMNG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400468   122 IGLGLGILLWGSSALLIGWASSRFGWFGLHPEEVSKPLLNYCGAGLCPLSAIIFFFVKS-DGHQRTSTEFMPLLIDdrrl 200
Cdd:pfam07857  81 IGLGVGILIWNTVNCLVGWAVTRFGLFGIPAQVPKSPFLNYIGIVLVVVGGFIFLFIKHvPKENETESDTTPLEME---- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400468   201 DPDSISPSDSWVDTISPKS--KRVFGCILAVFSGVLYGSAFVPVFYMKlhatNNSSMFIGSSQNEIDYCFAHYSGIFLTS 278
Cdd:pfam07857 157 HKKSLEQDLSSDDGLVKKSctRRIVCILLAIVSGFLYGSTFVPIIYIK----DNPPIYPGAPQDGLDYVFSHYTGIFLTS 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400468   279 TVYFLAYCAVMKNRPRIYPRAILPGFSSGLMWGLATYSWLMANYYLGAVITFPITNAGYSLVAALWGSVVFKEVKGIGNL 358
Cdd:pfam07857 233 TVYFFAYSIVKKNNPYVPSELVLPSIGSGILWAIAMTSWFVANQKLSQVVSYPIISRAPGLIAAAWSVFYFKEIQGKRNY 312

                         330       340
                  ....*....|....*....|.
gi 54400468   359 LLFALATCVVLAGSFLTAYSK 379
Cdd:pfam07857 313 ILLGIASAITLIGAIMVALSK 333
GRP cd23110
glucose/ribose porter family; The glucose/ribose porter (GRP) family (TC 2.A.7.5) includes two ...
 216-375 1.33e-09

glucose/ribose porter family; The glucose/ribose porter (GRP) family (TC 2.A.7.5) includes two functionally characterized members, a glucose uptake permease from Staphylococcus xylosus, and a probable ribose uptake permease from Lactobacillus sakei. Both proteins probably function by H(+) symport. This family also includes several putative and hypothetical membrane proteins that are probably involved in sugar transport across bacterial membranes. GRP family proteins have a distinctive topology: 10 putative transmembrane (TM) alpha-helical spanning domains per polypeptide chain, which apparently arose by intragenic duplication of an element encoding a primordial five-TM polypeptide. In Lactococcus lactis, GlcU was identified as the sole non-PTS (phosphoenolpyruvate:phosphotransferase systems) permease involved in the transport of glucose, which is driven by the proton-motive force. A gene from Bacillus subtilis, ycxE, that is homologous to glcU, could substitute for glcU in Escherichia coli glucose growth experiments and restored glucose repression in Staphylococcus xylosus glcU mutants. RbsU is encoded on the rbsUDK gene cluster, which encodes proteins involved in ribose uptake and phosphorylation. RbsR has been annotated as the repressor of the rbsUDK operon, based on its homology with RbsR repressors. The GRP family belongs to the Drug/Metabolite Transporter (DMT) superfamily (TC 2.A.7).


Pssm-ID: 438513 [Multi-domain]  Cd Length: 279  Bit Score: 58.62  E-value: 1.33e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400468 216 SPKSKRVFGCILAVFSGVLYGSAFVPvfyMKLHATNNSSMFIGSSqneidycfahySGIFLTSTVYFLaycaVMKNRPRI 295
Cdd:cd23110 139 KKSKNQKKGLLILLLSTIGYWSYSAI---PKLFSVSGLAIFLPQA-----------LGMLLGALIYAL----FTRKPKAL 200

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400468 296 YPRAILPGFSSGLMWGLATYSWLMANYYLGAVITFPITNAGySLVAALWGSVVFKEVKGIGNLLLFALATCVVLAGSFLT 375
Cdd:cd23110 201 KEKASWRNILTGLLWGIANLAYLLSAQANGVATAFTLSQLN-VVISTLGGILILHEKKTKRELRFTLIGLVLIVAGAVLT 279
GlcU COG4975
Glucose uptake protein GlcU [Carbohydrate transport and metabolism];
273-379 1.43e-06

Glucose uptake protein GlcU [Carbohydrate transport and metabolism];


Pssm-ID: 444000 [Multi-domain]  Cd Length: 288  Bit Score: 49.47  E-value: 1.43e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400468 273 GIFLTSTVYFLAYcavmknRPRIYPRAILPGFSSGLMWGLATYSWLMANYYLGAVITFPITNAGYSLVAALWGSVVFKEV 352
Cdd:COG4975  38 GALIFAIIVFLFV------QPELTGTIFIIGFLSGLFWAVGQINQFKSFKLLGVSKAMPISTGMQLVGTSLFGVILFGEW 111

                        90       100
                ....*....|....*....|....*..
gi 54400468 353 KGIGNLLLFALATCVVLAGSFLTAYSK 379
Cdd:COG4975 112 TTTTAKVLGFLALILIIIGAVLTSYQD 138
 
Name Accession Description Interval E-value
TMEM144 pfam07857
Transmembrane family, TMEM144 of transporters; Members of this family fall in to the drug ...
 42-379 4.23e-100

Transmembrane family, TMEM144 of transporters; Members of this family fall in to the drug/metabolite transporter (dmt) superfamily. They carry 10xTM domains arranged as 5+5. Although these two sets may originally have arisen by gene-duplication the divergence now is such that the two halves are no longer homologous.


Pssm-ID: 285141  Cd Length: 333  Bit Score: 300.12  E-value: 4.23e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400468    42 TYGYVTCAFAVLLYGSYFVPMKRIETGDGMFFQWICASGIWFVGLVVDTLFHPSKAHPAAMLGGALWATGHVSAVPVVKF 121
Cdd:pfam07857   1 IVGYVACLVSSVTFGSMFVPLKRFHSGDGFFVQWIMSLAILLVGLIVYATLGFPKFEPLAMLGGMLWATGNAFAVPIMNG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400468   122 IGLGLGILLWGSSALLIGWASSRFGWFGLHPEEVSKPLLNYCGAGLCPLSAIIFFFVKS-DGHQRTSTEFMPLLIDdrrl 200
Cdd:pfam07857  81 IGLGVGILIWNTVNCLVGWAVTRFGLFGIPAQVPKSPFLNYIGIVLVVVGGFIFLFIKHvPKENETESDTTPLEME---- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400468   201 DPDSISPSDSWVDTISPKS--KRVFGCILAVFSGVLYGSAFVPVFYMKlhatNNSSMFIGSSQNEIDYCFAHYSGIFLTS 278
Cdd:pfam07857 157 HKKSLEQDLSSDDGLVKKSctRRIVCILLAIVSGFLYGSTFVPIIYIK----DNPPIYPGAPQDGLDYVFSHYTGIFLTS 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400468   279 TVYFLAYCAVMKNRPRIYPRAILPGFSSGLMWGLATYSWLMANYYLGAVITFPITNAGYSLVAALWGSVVFKEVKGIGNL 358
Cdd:pfam07857 233 TVYFFAYSIVKKNNPYVPSELVLPSIGSGILWAIAMTSWFVANQKLSQVVSYPIISRAPGLIAAAWSVFYFKEIQGKRNY 312

                         330       340
                  ....*....|....*....|.
gi 54400468   359 LLFALATCVVLAGSFLTAYSK 379
Cdd:pfam07857 313 ILLGIASAITLIGAIMVALSK 333
GRP cd23110
glucose/ribose porter family; The glucose/ribose porter (GRP) family (TC 2.A.7.5) includes two ...
 216-375 1.33e-09

glucose/ribose porter family; The glucose/ribose porter (GRP) family (TC 2.A.7.5) includes two functionally characterized members, a glucose uptake permease from Staphylococcus xylosus, and a probable ribose uptake permease from Lactobacillus sakei. Both proteins probably function by H(+) symport. This family also includes several putative and hypothetical membrane proteins that are probably involved in sugar transport across bacterial membranes. GRP family proteins have a distinctive topology: 10 putative transmembrane (TM) alpha-helical spanning domains per polypeptide chain, which apparently arose by intragenic duplication of an element encoding a primordial five-TM polypeptide. In Lactococcus lactis, GlcU was identified as the sole non-PTS (phosphoenolpyruvate:phosphotransferase systems) permease involved in the transport of glucose, which is driven by the proton-motive force. A gene from Bacillus subtilis, ycxE, that is homologous to glcU, could substitute for glcU in Escherichia coli glucose growth experiments and restored glucose repression in Staphylococcus xylosus glcU mutants. RbsU is encoded on the rbsUDK gene cluster, which encodes proteins involved in ribose uptake and phosphorylation. RbsR has been annotated as the repressor of the rbsUDK operon, based on its homology with RbsR repressors. The GRP family belongs to the Drug/Metabolite Transporter (DMT) superfamily (TC 2.A.7).


Pssm-ID: 438513 [Multi-domain]  Cd Length: 279  Bit Score: 58.62  E-value: 1.33e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400468 216 SPKSKRVFGCILAVFSGVLYGSAFVPvfyMKLHATNNSSMFIGSSqneidycfahySGIFLTSTVYFLaycaVMKNRPRI 295
Cdd:cd23110 139 KKSKNQKKGLLILLLSTIGYWSYSAI---PKLFSVSGLAIFLPQA-----------LGMLLGALIYAL----FTRKPKAL 200

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400468 296 YPRAILPGFSSGLMWGLATYSWLMANYYLGAVITFPITNAGySLVAALWGSVVFKEVKGIGNLLLFALATCVVLAGSFLT 375
Cdd:cd23110 201 KEKASWRNILTGLLWGIANLAYLLSAQANGVATAFTLSQLN-VVISTLGGILILHEKKTKRELRFTLIGLVLIVAGAVLT 279
GRP cd23110
glucose/ribose porter family; The glucose/ribose porter (GRP) family (TC 2.A.7.5) includes two ...
 273-379 1.12e-07

glucose/ribose porter family; The glucose/ribose porter (GRP) family (TC 2.A.7.5) includes two functionally characterized members, a glucose uptake permease from Staphylococcus xylosus, and a probable ribose uptake permease from Lactobacillus sakei. Both proteins probably function by H(+) symport. This family also includes several putative and hypothetical membrane proteins that are probably involved in sugar transport across bacterial membranes. GRP family proteins have a distinctive topology: 10 putative transmembrane (TM) alpha-helical spanning domains per polypeptide chain, which apparently arose by intragenic duplication of an element encoding a primordial five-TM polypeptide. In Lactococcus lactis, GlcU was identified as the sole non-PTS (phosphoenolpyruvate:phosphotransferase systems) permease involved in the transport of glucose, which is driven by the proton-motive force. A gene from Bacillus subtilis, ycxE, that is homologous to glcU, could substitute for glcU in Escherichia coli glucose growth experiments and restored glucose repression in Staphylococcus xylosus glcU mutants. RbsU is encoded on the rbsUDK gene cluster, which encodes proteins involved in ribose uptake and phosphorylation. RbsR has been annotated as the repressor of the rbsUDK operon, based on its homology with RbsR repressors. The GRP family belongs to the Drug/Metabolite Transporter (DMT) superfamily (TC 2.A.7).


Pssm-ID: 438513 [Multi-domain]  Cd Length: 279  Bit Score: 52.46  E-value: 1.12e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400468 273 GIFLTSTVYFLAYcavmknRPRIYPRAILPGFSSGLMWGLATYSWLMANYYLGAVITFPITNAGYSLVAALWGSVVFKEV 352
Cdd:cd23110  34 GALIVALVVFLFL------GPTISPTLFLLAFLSGAFWSIGQIGQFKAFKRIGVSRTMPISTGLQLVGTSLIGVLLFGEW 107

                        90       100
                ....*....|....*....|....*..
gi 54400468 353 KGIGNLLLFALATCVVLAGSFLTAYSK 379
Cdd:cd23110 108 SGTGAKLLGLLALALIIIGVLLTSYTD 134
GlcU COG4975
Glucose uptake protein GlcU [Carbohydrate transport and metabolism];
273-379 1.43e-06

Glucose uptake protein GlcU [Carbohydrate transport and metabolism];


Pssm-ID: 444000 [Multi-domain]  Cd Length: 288  Bit Score: 49.47  E-value: 1.43e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400468 273 GIFLTSTVYFLAYcavmknRPRIYPRAILPGFSSGLMWGLATYSWLMANYYLGAVITFPITNAGYSLVAALWGSVVFKEV 352
Cdd:COG4975  38 GALIFAIIVFLFV------QPELTGTIFIIGFLSGLFWAVGQINQFKSFKLLGVSKAMPISTGMQLVGTSLFGVILFGEW 111

                        90       100
                ....*....|....*....|....*..
gi 54400468 353 KGIGNLLLFALATCVVLAGSFLTAYSK 379
Cdd:COG4975 112 TTTTAKVLGFLALILIIIGAVLTSYQD 138
Sugar_transport pfam06800
Sugar transport protein; This is a family of bacterial sugar transporters approximately 300 ...
 293-379 8.80e-05

Sugar transport protein; This is a family of bacterial sugar transporters approximately 300 residues long. Members include glucose uptake proteins, ribose transport proteins, and several putative and hypothetical membrane proteins probably involved in sugar transport across bacterial membranes. These members are transmembrane proteins which are usually 5+5 duplications. This model recognizes a set of five TMs,


Pssm-ID: 429127 [Multi-domain]  Cd Length: 280  Bit Score: 43.80  E-value: 8.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400468   293 PRIYPRAILPGFSSGLMWGLATYSWLMANYYLGAVITFPITNAGYSLVAALWGSVVFKEVKGIGNLLLFALATCVVLAGS 372
Cdd:pfam06800  48 PTLTLKIFIFGFISGAFWAFGQIGQFKSFKLVGVSKAMPISTGMQLVGTSLFGVFAFGEWSTIIQKILGFLALILIVIGI 127


                  ....*..
gi 54400468   373 FLTAYSK 379
Cdd:pfam06800 128 YLTSWTE 134
ribose_uptake_RbsU cd23111
ribose uptake protein RbsU and similar proteins; This group includes ribose uptake protein ...
 273-378 2.64e-04

ribose uptake protein RbsU and similar proteins; This group includes ribose uptake protein RbsU and similar proteins. RbsU is encoded on the rbsUDK gene cluster, which encodes proteins involved in ribose uptake and phosphorylation. RbsR has been annotated as the repressor of the rbsUDK operon, based on its homology with RbsR repressors. RbsU belongs to the glucose/ribose porter (GRP) family (TC 2.A.7.5) and probably functions by H(+) symport. GRP family proteins have a distinctive topology: 10 putative transmembrane (TM) alpha-helical spanning domains per polypeptide chain, which apparently arose by intragenic duplication of an element encoding a primordial five-TM polypeptide. The GRP family belongs to the Drug/Metabolite Transporter (DMT) superfamily (TC 2.A.7).


Pssm-ID: 438514 [Multi-domain]  Cd Length: 285  Bit Score: 42.47  E-value: 2.64e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 54400468 273 GIFLTSTVYFLaycavMKNRPRIYPRAILPGFSSGLMWGLATYSWLMANYYLGAVITFPITNAGYSLVAALWGSVVFKEV 352
Cdd:cd23111  34 GTLIVAIVVAL-----ITGPPLPTGSDFLLSFLSGAGWAFGQILQFKAFTLIGVSRAMPISTGFQLIGTSLWGVIFLGEW 108

                        90       100
                ....*....|....*....|....*.
gi 54400468 353 KGIGNLLLFALATCVVLAGSFLTAYS 378
Cdd:cd23111 109 PSLTAKIIGFLALILIIIGAYLTTWS 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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