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Conserved domains on  [gi|1032199645|ref|NP_001004117|]
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6-phosphogluconolactonase [Danio rerio]

Protein Classification

6-phosphogluconolactonase( domain architecture ID 10105380)

6-phosphogluconolactonase catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate, which is the the second step of the oxidative phase of the pentose phosphate pathway

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 14-233 7.41e-94

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


:

Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 274.82  E-value: 7.41e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645  14 ELGSSLAQLLSSRAEKALSSGGScFSLGLSGGSLVSILSKELPAVPNLDCSKWLIGFCDERLVPFSDPESTYGLYKNQLF 93
Cdd:cd01400     2 ALAEALADRIAEALAAAIAKRGR-FSLALSGGSTPKPLYELLAAAPALDWSKVHVFLGDERCVPPDDPDSNYRLAREALL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645  94 GKINIPEERILAIDPSLPVKECAEDYASKLSKAFSteKIPVFDVLLLGMGPDGHTCSLFPDHP-LLQERQKTVAPISDSP 172
Cdd:cd01400    81 SHVAIPAANIHPIPTELGPEDAAAAYEKELRALFG--GVPPFDLVLLGMGPDGHTASLFPGHPaLLEETDRLVVAVTDSP 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1032199645 173 KPPPQRVTMTLPMVNAARCVVFVSTGGSKAPVLKHVLEGGEGPALPAALVSPDQGELFWLL 233
Cdd:cd01400   159 KPPPERITLTLPVLNNARRVVFLVTGAEKAEALKRALAGPDPEELPAARVLPRPGEVLWFL 219
 
Name Accession Description Interval E-value
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 14-233 7.41e-94

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 274.82  E-value: 7.41e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645  14 ELGSSLAQLLSSRAEKALSSGGScFSLGLSGGSLVSILSKELPAVPNLDCSKWLIGFCDERLVPFSDPESTYGLYKNQLF 93
Cdd:cd01400     2 ALAEALADRIAEALAAAIAKRGR-FSLALSGGSTPKPLYELLAAAPALDWSKVHVFLGDERCVPPDDPDSNYRLAREALL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645  94 GKINIPEERILAIDPSLPVKECAEDYASKLSKAFSteKIPVFDVLLLGMGPDGHTCSLFPDHP-LLQERQKTVAPISDSP 172
Cdd:cd01400    81 SHVAIPAANIHPIPTELGPEDAAAAYEKELRALFG--GVPPFDLVLLGMGPDGHTASLFPGHPaLLEETDRLVVAVTDSP 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1032199645 173 KPPPQRVTMTLPMVNAARCVVFVSTGGSKAPVLKHVLEGGEGPALPAALVSPDQGELFWLL 233
Cdd:cd01400   159 KPPPERITLTLPVLNNARRVVFLVTGAEKAEALKRALAGPDPEELPAARVLPRPGEVLWFL 219
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
10-231 8.67e-91

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 267.18  E-value: 8.67e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645  10 SSVGELGSSLAQLLSSRAEKALSSGGScFSLGLSGGSLVSILSKELPAVPN-LDCSKWLIGFCDERLVPFSDPESTYGLY 88
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAALAERGR-FTLALSGGSTPKPLYELLAAAPArLDWSRVHVFWGDERCVPPDDPDSNYGMA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645  89 KNQLFGKINIPEERILAID-PSLPVKECAEDYASKLSKAFSTEKIPVFDVLLLGMGPDGHTCSLFPDHPLLQERQKTVAP 167
Cdd:pfam01182  80 REALLSHVPIPASNVHPIPaSAADPEEAAAAYEAELRELLPDLELPVFDLVLLGMGPDGHTASLFPGSPALEETDRLVVA 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1032199645 168 ISDSPKPPPQRVTMTLPMVNAARCVVFVSTGGSKAPVLKHVLEGGEGPaLPAALVSPDQGELFW 231
Cdd:pfam01182 160 VTDSPKPPPERITLTLPVLNAARRVWFLVTGAGKADALRRALAGDPDP-LPAALVRPGAGETVW 222
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 8-241 3.65e-82

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 245.75  E-value: 3.65e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645   8 VFSSVGELGSSLAQLLSSRAEKALSSGGScFSLGLSGGSLVSILSKELPAVPnLDCSKWLIGFCDERLVPFSDPESTYGL 87
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALAERGQ-FSLALSGGRSPIALLEALAAQP-LDWSRIHLFLGDERYVPLDHADSNTGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645  88 YKNQLFGKINIPEERILAIDPSLP-VKECAEDYASKLSKAFSTEKIPVFDVLLLGMGPDGHTCSLFPDHPLLQERQKTVA 166
Cdd:TIGR01198  79 AREALLDRVAIPASNIHPMPTELSdIEEAAELYEQELAAAFQPIVFPVFDLLLLGMGPDGHTASLFPHTPALQETERLVT 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1032199645 167 PISDSPKPPPQRVTMTLPMVNAARCVVFVSTGGSKAPVLKHVLEGGEGPALPAALVSPDQGELFWLLDEPAAASL 241
Cdd:TIGR01198 159 VLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVLHSGKTLWLLDYAAARKL 233
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 8-241 1.13e-64

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 202.40  E-value: 1.13e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645   8 VFSSVGELGSSLAQLLSSRAEKALSSGGScFSLGLSGGSLVSILSK--ELPAVPNLDCSKWLIGFCDERLVPFSDPESTY 85
Cdd:PLN02360   15 VHENLDELSTDLAEYIAELSEASVKERGV-FAIALSGGSLISFMGKlcEAPYNKTVDWAKWYIFWADERVVAKNHADSNY 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645  86 GLYKNQLFGKINIPEERILAIDPSLPVKECAEDYASKLSKAFSTEKI--------PVFDVLLLGMGPDGHTCSLFPDHPL 157
Cdd:PLN02360   94 KLAKDGLLSKVPVVPSHVYSINDTVTAEEAATDYEFAIRQLVKTRTIgvsdisdcPKFDLILLGMGSDGHVASLFPNHPA 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645 158 LQERQKTVAPISDSPKPPPQRVTMTLPMVNAARCVVFVSTGGSKAPV----LKHVLEGGEGPALPAALVSPDQGELFWLL 233
Cdd:PLN02360  174 LEEKDDWVTFITDSPKPPPERITFTLPVINSASNVAVVATGESKANAvhlaIDDVTEGPDAPSLPARMVQPTKGKLVWFL 253


                  ....*...
gi 1032199645 234 DEPAAASL 241
Cdd:PLN02360  254 DKPAASKL 261
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 5-242 1.17e-60

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 191.53  E-value: 1.17e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645   5 RVLVFSSVGELGSSLAQLLSSRAEKALSSGGScFSLGLSGGS--------LVsilskELPAVPNLDCSKWLIGFCDERL- 75
Cdd:COG0363     3 RVIIFPDAEELAAAAAERAAERIAEAIAEKGR-AVLGLAGGStplglyeeLA-----RLHKEGGLDWSRVHVFNLDEYVg 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645  76 VPFSDPESTYGLYKNQLFGKINIPEERILAIDPSL--PVKECAEdYASKLSKAfstekiPVFDVLLLGMGPDGHTCSLFP 153
Cdd:COG0363    77 LPPDHPQSNRRFMREALLDHVDIPPENIHIPDGEAedPEAAAAR-YEALIAEA------GGIDLQLLGIGEDGHIAFNFP 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645 154 DHPLLQERQKTVAP-----------ISDSPKPPPQRVTMTLPMVNAARCVVFVSTGGSKAPVLKHVLEGGEGPALPAALV 222
Cdd:COG0363   150 GSPFLSETDRVVTLdestrqanarfFGSIPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASIL 229

                         250       260
                  ....*....|....*....|
gi 1032199645 223 SPdQGELFWLLDEPAAASLT 242
Cdd:COG0363   230 QG-HPNVTWFLDEAAASLLT 248
 
Name Accession Description Interval E-value
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 14-233 7.41e-94

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 274.82  E-value: 7.41e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645  14 ELGSSLAQLLSSRAEKALSSGGScFSLGLSGGSLVSILSKELPAVPNLDCSKWLIGFCDERLVPFSDPESTYGLYKNQLF 93
Cdd:cd01400     2 ALAEALADRIAEALAAAIAKRGR-FSLALSGGSTPKPLYELLAAAPALDWSKVHVFLGDERCVPPDDPDSNYRLAREALL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645  94 GKINIPEERILAIDPSLPVKECAEDYASKLSKAFSteKIPVFDVLLLGMGPDGHTCSLFPDHP-LLQERQKTVAPISDSP 172
Cdd:cd01400    81 SHVAIPAANIHPIPTELGPEDAAAAYEKELRALFG--GVPPFDLVLLGMGPDGHTASLFPGHPaLLEETDRLVVAVTDSP 158

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1032199645 173 KPPPQRVTMTLPMVNAARCVVFVSTGGSKAPVLKHVLEGGEGPALPAALVSPDQGELFWLL 233
Cdd:cd01400   159 KPPPERITLTLPVLNNARRVVFLVTGAEKAEALKRALAGPDPEELPAARVLPRPGEVLWFL 219
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
10-231 8.67e-91

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 267.18  E-value: 8.67e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645  10 SSVGELGSSLAQLLSSRAEKALSSGGScFSLGLSGGSLVSILSKELPAVPN-LDCSKWLIGFCDERLVPFSDPESTYGLY 88
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAALAERGR-FTLALSGGSTPKPLYELLAAAPArLDWSRVHVFWGDERCVPPDDPDSNYGMA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645  89 KNQLFGKINIPEERILAID-PSLPVKECAEDYASKLSKAFSTEKIPVFDVLLLGMGPDGHTCSLFPDHPLLQERQKTVAP 167
Cdd:pfam01182  80 REALLSHVPIPASNVHPIPaSAADPEEAAAAYEAELRELLPDLELPVFDLVLLGMGPDGHTASLFPGSPALEETDRLVVA 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1032199645 168 ISDSPKPPPQRVTMTLPMVNAARCVVFVSTGGSKAPVLKHVLEGGEGPaLPAALVSPDQGELFW 231
Cdd:pfam01182 160 VTDSPKPPPERITLTLPVLNAARRVWFLVTGAGKADALRRALAGDPDP-LPAALVRPGAGETVW 222
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 8-241 3.65e-82

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 245.75  E-value: 3.65e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645   8 VFSSVGELGSSLAQLLSSRAEKALSSGGScFSLGLSGGSLVSILSKELPAVPnLDCSKWLIGFCDERLVPFSDPESTYGL 87
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALAERGQ-FSLALSGGRSPIALLEALAAQP-LDWSRIHLFLGDERYVPLDHADSNTGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645  88 YKNQLFGKINIPEERILAIDPSLP-VKECAEDYASKLSKAFSTEKIPVFDVLLLGMGPDGHTCSLFPDHPLLQERQKTVA 166
Cdd:TIGR01198  79 AREALLDRVAIPASNIHPMPTELSdIEEAAELYEQELAAAFQPIVFPVFDLLLLGMGPDGHTASLFPHTPALQETERLVT 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1032199645 167 PISDSPKPPPQRVTMTLPMVNAARCVVFVSTGGSKAPVLKHVLEGGEGPALPAALVSPDQGELFWLLDEPAAASL 241
Cdd:TIGR01198 159 VLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVLHSGKTLWLLDYAAARKL 233
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 8-241 1.13e-64

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 202.40  E-value: 1.13e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645   8 VFSSVGELGSSLAQLLSSRAEKALSSGGScFSLGLSGGSLVSILSK--ELPAVPNLDCSKWLIGFCDERLVPFSDPESTY 85
Cdd:PLN02360   15 VHENLDELSTDLAEYIAELSEASVKERGV-FAIALSGGSLISFMGKlcEAPYNKTVDWAKWYIFWADERVVAKNHADSNY 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645  86 GLYKNQLFGKINIPEERILAIDPSLPVKECAEDYASKLSKAFSTEKI--------PVFDVLLLGMGPDGHTCSLFPDHPL 157
Cdd:PLN02360   94 KLAKDGLLSKVPVVPSHVYSINDTVTAEEAATDYEFAIRQLVKTRTIgvsdisdcPKFDLILLGMGSDGHVASLFPNHPA 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645 158 LQERQKTVAPISDSPKPPPQRVTMTLPMVNAARCVVFVSTGGSKAPV----LKHVLEGGEGPALPAALVSPDQGELFWLL 233
Cdd:PLN02360  174 LEEKDDWVTFITDSPKPPPERITFTLPVINSASNVAVVATGESKANAvhlaIDDVTEGPDAPSLPARMVQPTKGKLVWFL 253


                  ....*...
gi 1032199645 234 DEPAAASL 241
Cdd:PLN02360  254 DKPAASKL 261
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 5-242 1.17e-60

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 191.53  E-value: 1.17e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645   5 RVLVFSSVGELGSSLAQLLSSRAEKALSSGGScFSLGLSGGS--------LVsilskELPAVPNLDCSKWLIGFCDERL- 75
Cdd:COG0363     3 RVIIFPDAEELAAAAAERAAERIAEAIAEKGR-AVLGLAGGStplglyeeLA-----RLHKEGGLDWSRVHVFNLDEYVg 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645  76 VPFSDPESTYGLYKNQLFGKINIPEERILAIDPSL--PVKECAEdYASKLSKAfstekiPVFDVLLLGMGPDGHTCSLFP 153
Cdd:COG0363    77 LPPDHPQSNRRFMREALLDHVDIPPENIHIPDGEAedPEAAAAR-YEALIAEA------GGIDLQLLGIGEDGHIAFNFP 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645 154 DHPLLQERQKTVAP-----------ISDSPKPPPQRVTMTLPMVNAARCVVFVSTGGSKAPVLKHVLEGGEGPALPAALV 222
Cdd:COG0363   150 GSPFLSETDRVVTLdestrqanarfFGSIPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASIL 229

                         250       260
                  ....*....|....*....|
gi 1032199645 223 SPdQGELFWLLDEPAAASLT 242
Cdd:COG0363   230 QG-HPNVTWFLDEAAASLLT 248
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 38-241 6.52e-18

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 79.84  E-value: 6.52e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645  38 FSLGLSGGS--------LVSILSKElpavpNLDCSKWlIGF-CDERL-VPFSDPESTYGLYKNQLFGKINIPEERILAID 107
Cdd:cd01399    21 AVLGLATGStplgvyeeLIELHKEG-----GLSFSNV-TTFnLDEYVgLPPDHPQSYHYFMRENLFDHIDIKPENIHIPD 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645 108 --PSLPVKECAEdYASKLSKAfstEKIpvfDVLLLGMGPDGHTCslF--PDHPL--------LQE--RQKTVAPISDSPK 173
Cdd:cd01399    95 gnAADLEAECRR-YEALIAEA---GGI---DLQLLGIGENGHIG--FnePGSSLdsrtrvvtLDEstRQANARFFDGDED 165

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1032199645 174 PPPQRVTMTLPMVNAARCVVFVSTGGSKAPVLKHVLEGGEGPALPA--------ALVspdqgelfwLLDEPAAASL 241
Cdd:cd01399   166 VPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPAsilqlhpnVTV---------ILDEAAASEL 232
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 5-242 1.65e-14

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 71.01  E-value: 1.65e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645   5 RVLVFSSVGELGSSLAQLLSSRAEKALSSGGSCFSLGL-SGGSLVSILSK--ELPAVPNLDCSKwLIGF-CDERL-VPFS 79
Cdd:PRK00443    2 RLIILKTAEEVGKWAARHIANRINAFLPTKERPFVLGLaTGSSPLETYKAliELHKAGKVDFSR-VTTFnLDEYVgLPAD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645  80 DPESTYGLYKNQLFGKINIPEERILAID--PSLPVKECAEdYASKLSKAfstEKIpvfDVLLLGMGPDGH------TCSL 151
Cdd:PRK00443   81 HPESYRYFMRENFFDHVDIPPENINLLNgnAPDPEAECRR-YEEKIKSA---GGI---DLQILGIGENGHiafnepGSSF 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645 152 fpDHPLlqeRQKTVAP-------------ISDSPKpppQRVTMTLPMVNAARCVVFVSTGGSKAPVLKHVLEGGEGPALP 218
Cdd:PRK00443  154 --ASRT---RIKTLTEdtriansrffdgdIEQVPK---YALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMWP 225

                         250       260
                  ....*....|....*....|....*
gi 1032199645 219 A-ALVSPDQGELFwlLDEPAAASLT 242
Cdd:PRK00443  226 AsILQLHPKATLV--LDEAAASELK 248
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
72-241 1.42e-10

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 59.76  E-value: 1.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645  72 DErlVPFSdPESTYGL----YKNQLFGKINIPEERILAIDpslpvKECAEDYASKLSKAFStekipvFDVLLLGMGPDGH 147
Cdd:PRK12358   66 DE--IPFR-GKEGEGVtitnLRNLFFTPAGIKEENIHKLT-----IDNYREHDQKLARDGG------LDLVVLGLGADGH 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645 148 TCSLFPDH----------PLLQERQKTVAPI---SDSPKPPPQRVTMTLPMVNAARCVVFVSTGGSKAPVLKHVLEGGEG 214
Cdd:PRK12358  132 FCGNLPGTthfhdetvevPIQGEMVDIVAHGelgGDFSLVPDSYVTMGPKSIMAAKNLLLIVNGKGKAQILKKVLQGPVT 211

                         170       180
                  ....*....|....*....|....*....
gi 1032199645 215 PALPAALVS--PDqgeLFWLLDEPAAASL 241
Cdd:PRK12358  212 EDVPASILQlhPN---LTVILDEAAAAEL 237
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 77-241 8.70e-10

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 57.46  E-value: 8.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645  77 PFSDPESTYGLYKNQLFGKINIPEERILAIDPSLP--VKECAEdYASKLskafstEKIPVFDVLLLGMGPDGHTCSLFPD 154
Cdd:PTZ00285   78 PRDHPQSYHYFMKENFFDHVDIKEENRHILNGTAPdlEEECRR-YEEKI------RAVGGIDLFLAGIGTDGHIAFNEPG 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645 155 HPLL-QERQKTVAPIS----------DSPKPPPQRVTMTLPMVNAARCVVFVSTGGSKAPVLKHVLEGGEGPALPAALVS 223
Cdd:PTZ00285  151 SSLDsRTRVKSLNQETidanarffgnDISKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPASALQ 230

                         170
                  ....*....|....*...
gi 1032199645 224 PDQGELFWlLDEPAAASL 241
Cdd:PTZ00285  231 MHPAAVLC-LDEDATLEL 247
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
 89-248 1.78e-09

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 57.73  E-value: 1.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645  89 KNQLFGKINIPEERILAIDPSLPVKECAE---DYASKLSKAFStekipvFDVLLLGMGPDGH-------------TCSLF 152
Cdd:PRK02122  116 KENLFDHVDIPPENIHIPDGTIPKEEIDEycrDYEEKIEAAGG------IDFQLLGIGRTGHigfnepgsgrnsrTRLVT 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645 153 PDHPllqERQKTVAPISDSPKPPPQRVTMTLPMVNAARCVVFVSTGGSKAPVLKHVLEGGEGPALPAALVSPDQGELFwL 232
Cdd:PRK02122  190 LDHI---TRRDAASDFFGEENVPRKAITMGVGTILKARRIVLLAWGEHKAPIIKRAVEGEISDEVPASYLQEHPNATF-V 265

                         170
                  ....*....|....*.
gi 1032199645 233 LDEPAAASLTSpVERP 248
Cdd:PRK02122  266 LDLAAASELTR-IKTP 280
SugarP_isomerase cd00458
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 38-163 1.01e-03

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


Pssm-ID: 238258  Cd Length: 169  Bit Score: 38.87  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1032199645  38 FSLGLSGGSLVSILSKELPAVPNLDCSKWLIGF-CDERLVPFSDPESTYGLYKNQLFGKINIPEERILAIDPSLP-VKEC 115
Cdd:cd00458    22 MVIGLGTGSTPAYFYKLLGEKLKRGEISDIVGFpTDERYVPLDSDQSNFRQAKLLAFEHDIIPASNVHYVDTSLPiEKAC 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1032199645 116 AEDYASKLSkafSTEKIpvfDVLLLGMGPDGHTCSLfpdhpLLQERQK 163
Cdd:cd00458   102 EKYEREILD---QVDAI---DLAVDGAGYRAGTVIV-----LVDGRKK 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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