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Conserved domains on  [gi|50540514|ref|NP_001002722|]
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tetratricopeptide repeat protein 33 [Danio rerio]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 708416)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 28-207 1.74e-12

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 66.94  E-value: 1.74e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50540514  28 QADEDEVEREGVDWLHVIKRKREVLLEDCAAKSKRLKEEGALLAEQDRNWEALKKWDEAVQLTPEDAVLYEMKSQVLITL 107
Cdd:COG3914  46 LLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLAL 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50540514 108 GEVFLAVQSAEMATRLRPIWWEAWQTLGRAQLSLGEVELAVRSFQVALHLHPSERPLWeedLNWALKLREnqqslrekAS 187
Cdd:COG3914 126 GRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEAL---NNLGNALQD--------LG 194

                       170       180
                ....*....|....*....|
gi 50540514 188 QVDEARRLLVEAPELKGDYD 207
Cdd:COG3914 195 RLEEAIAAYRRALELDPDNA 214
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 28-207 1.74e-12

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 66.94  E-value: 1.74e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50540514  28 QADEDEVEREGVDWLHVIKRKREVLLEDCAAKSKRLKEEGALLAEQDRNWEALKKWDEAVQLTPEDAVLYEMKSQVLITL 107
Cdd:COG3914  46 LLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLAL 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50540514 108 GEVFLAVQSAEMATRLRPIWWEAWQTLGRAQLSLGEVELAVRSFQVALHLHPSERPLWeedLNWALKLREnqqslrekAS 187
Cdd:COG3914 126 GRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEAL---NNLGNALQD--------LG 194

                       170       180
                ....*....|....*....|
gi 50540514 188 QVDEARRLLVEAPELKGDYD 207
Cdd:COG3914 195 RLEEAIAAYRRALELDPDNA 214
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 68-207 2.45e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.30  E-value: 2.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50540514    68 ALLAEQDRNWEALKKWDEAVQLTPEDAVLYEMKSQVLITLGEVFLAVQSAEMATRLRPIWWEAWQTLGRAQLSLGEVELA 147
Cdd:TIGR02917 541 GLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKA 620

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 50540514   148 VRSFQVALHLHPSERPLWeedlnwaLKLRENQQSLREkasqVDEARRLLVEAPELKGDYD 207
Cdd:TIGR02917 621 VSSFKKLLALQPDSALAL-------LLLADAYAVMKN----YAKAITSLKRALELKPDNT 669
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 28-207 1.74e-12

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 66.94  E-value: 1.74e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50540514  28 QADEDEVEREGVDWLHVIKRKREVLLEDCAAKSKRLKEEGALLAEQDRNWEALKKWDEAVQLTPEDAVLYEMKSQVLITL 107
Cdd:COG3914  46 LLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLAL 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50540514 108 GEVFLAVQSAEMATRLRPIWWEAWQTLGRAQLSLGEVELAVRSFQVALHLHPSERPLWeedLNWALKLREnqqslrekAS 187
Cdd:COG3914 126 GRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEAL---NNLGNALQD--------LG 194

                       170       180
                ....*....|....*....|
gi 50540514 188 QVDEARRLLVEAPELKGDYD 207
Cdd:COG3914 195 RLEEAIAAYRRALELDPDNA 214
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 67-165 2.27e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 60.39  E-value: 2.27e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50540514  67 GALLAEQDRNWEALKKWDEAVQLTPEDAVLYEMKSQVLITLGEVFLAVQSAEMATRLRPIWWEAWQTLGRAQLSLGEVEL 146
Cdd:COG3914 119 GNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEE 198

                        90
                ....*....|....*....
gi 50540514 147 AVRSFQVALHLHPSERPLW 165
Cdd:COG3914 199 AIAAYRRALELDPDNADAH 217
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
67-230 1.32e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 54.24  E-value: 1.32e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50540514  67 GALLAEQDRNWEALKKWDEAVQLTPEDAVLYEMKSQVLITLGEVFLAVQSAEMATRLRPIWWEAWQTLGRAQLSLGEVEL 146
Cdd:COG0457  49 GLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDE 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50540514 147 AVRSFQVALHLHPSERPLWEEdLNWALKLRENQQSLREKASQVDEARRLLVEAPELKGDYDFESDEVIEACSAMADRQKQ 226
Cdd:COG0457 129 AIEAYERALELDPDDADALYN-LGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQAL 207


                ....
gi 50540514 227 YEDL 230
Cdd:COG0457 208 RKKL 211
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 57-201 1.40e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 52.50  E-value: 1.40e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50540514  57 AAKSKRLKEEGALLAEQDRNWEALKKWDEAVQLTPEDAVLYEMKSQVLITLGEVFLAVQSAEMATRLRPIWWEAWQTLGR 136
Cdd:COG4783   1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGL 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 50540514 137 AQLSLGEVELAVRSFQVALHLHPserplweEDLNWALKLRENQQSLREKASQVDEARRLLVEAPE 201
Cdd:COG4783  81 ALLKAGDYDEALALLEKALKLDP-------EHPEAYLRLARAYRALGRPDEAIAALEKALELDPD 138
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
67-234 1.55e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 53.86  E-value: 1.55e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50540514  67 GALLAEQDRNWEALKKWDEAVQLTPEDAVLYEMKSQVLITLGEVFLAVQSAEMATRLRPIWWEAWQTLGRAQLSLGEVEL 146
Cdd:COG0457  15 GLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEE 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50540514 147 AVRSFQVALHLHPSERPLWeedlnwalklrENQQSLREKASQVDEARRLLVEAPELKGDYDFESDEVIEACSAMADRQKQ 226
Cdd:COG0457  95 ALEDYDKALELDPDDAEAL-----------YNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEA 163


                ....*...
gi 50540514 227 YEDLKKKA 234
Cdd:COG0457 164 LELLEKLE 171
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
67-229 1.43e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.16  E-value: 1.43e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50540514  67 GALLAEQDRNWEALKKWDEAVQLTPEDAVLYEMKSQVLITLGEVFLAVQSAEMATRLRPIWWEAWQTLGRAQLSLGEVEL 146
Cdd:COG0457  83 GLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEE 162

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50540514 147 AVRSFQVALHLHPSERPLWEEDLNWALKLRENQQSLREKASQVDEARRLLVEAPELKGDYDFESDEVIEACSAMADRQKQ 226
Cdd:COG0457 163 ALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALALYQ 242


                ...
gi 50540514 227 YED 229
Cdd:COG0457 243 YRA 245
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 17-159 6.68e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 48.03  E-value: 6.68e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50540514  17 QTVQQFEQDSEQADEDEVEREGVDWLHVIKRKREVLLEDCAAKSKRLKEEGALLAEQDRNWEALKKWDEAVQLTPEDAVL 96
Cdd:COG5010  11 PLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPEL 90

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 50540514  97 YEMKSQVLITLGEVFLAVQSAEMATRLRPIWWEAWQTLGRAQLSLGEVELAVRSFQVALHLHP 159
Cdd:COG5010  91 YYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 67-161 6.98e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.49  E-value: 6.98e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50540514  67 GALLAEQDRNWEALKKWDEAVQLTPEDAVLYEMKSQVLITLGEVFLAVQSAEMATRLRPIWWEAWQTLGRAQLSLGEVEL 146
Cdd:COG4783  45 GEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDE 124

                        90
                ....*....|....*
gi 50540514 147 AVRSFQVALHLHPSE 161
Cdd:COG4783 125 AIAALEKALELDPDD 139
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
69-160 1.02e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 43.24  E-value: 1.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50540514  69 LLAEQDRNWEALKKWDEAVQLTPEDAVLYEMKSQVLITLGEVFLAVQsAEMATRLRPIWWEAWQTLGRAQLSLGEVELAV 148
Cdd:COG3063   1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEAL 79

                        90
                ....*....|..
gi 50540514 149 RSFQVALHLHPS 160
Cdd:COG3063  80 AYLERALELDPS 91
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 68-202 1.25e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.41  E-value: 1.25e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50540514  68 ALLAEQDRNWE-ALKKWDEAVQLTPEDAVLYEMKSQVLITLGEVFLAVQSAEMATRLRPIWWEAWQTLGRAQLSLGEVEL 146
Cdd:COG2956 117 AEIYEQEGDWEkAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEE 196

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 50540514 147 AVRSFQVALHLHPserplweEDLNWALKLRENQQSLREKASQVDEARRLLVEAPEL 202
Cdd:COG2956 197 AIAALERALEQDP-------DYLPALPRLAELYEKLGDPEEALELLRKALELDPSD 245
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 67-164 3.59e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 41.52  E-value: 3.59e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50540514  67 GALLAEQDRNWEALKKWDEAVQLTPEDAVLYEMKSQVLITLGEVFLAVQSAEMATRLRPIWWEAWQTLGRAQLSLGEVEL 146
Cdd:COG3914 153 GEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEV 232

                        90
                ....*....|....*...
gi 50540514 147 AVRSFQVALHLHPSERPL 164
Cdd:COG3914 233 YDRFEELLAALARGPSEL 250
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 67-163 3.91e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 39.60  E-value: 3.91e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50540514  67 GALLAEQDRNWEALKKWDEAVQLTPEDAVLYEMKSQVLITLGEVFLAVQSAEMATRLRPIWWEAWQTLGRAQLSLGEVEL 146
Cdd:COG4235  24 GRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAE 103

                        90
                ....*....|....*..
gi 50540514 147 AVRSFQVALHLHPSERP 163
Cdd:COG4235 104 AIAAWQKLLALLPADAP 120
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 78-161 6.27e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 38.83  E-value: 6.27e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50540514  78 EALKKWDEAVQLTPEDAVLYEMKSQVLITLGEVFLAVQSAEMATRLRPIWWEAWQTLGRAQLSLGEVELAVRSFQVALHL 157
Cdd:COG4235   1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80


                ....
gi 50540514 158 HPSE 161
Cdd:COG4235  81 DPDN 84
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 42-202 1.64e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 38.02  E-value: 1.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50540514  42 LHVIKRKREVLLEDCAAKSKRLKEEGALLAEQDRNWEALKKWDEAVQLTPEDAVLYEMKSQVLITLGEVFLAVQSAEMAT 121
Cdd:COG5010   2 RALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQAL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50540514 122 RLRPIWWEAWQTLGRAQLSLGEVELAVRSFQVALHLHPSErplweedlnwaLKLRENQQSLREKASQVDEARRLLVEAPE 201
Cdd:COG5010  82 QLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDN-----------PNAYSNLAALLLSLGQDDEAKAALQRALG 150


                .
gi 50540514 202 L 202
Cdd:COG5010 151 T 151
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 65-207 1.83e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.94  E-value: 1.83e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50540514  65 EEGALLAEQDRNWEALKKWDEAVQLTPEDAVLYEMKSQVLITLGEVFLAVQSAEMATRLRPIWWEAWQTLGRAQLSLGEV 144
Cdd:COG2956  13 FKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLL 92

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 50540514 145 ELAVRSFQVALHLHPSERPLWEEDLNWALKLRENQQS------LREKASQVDEARRLLVEAPELKGDYD 207
Cdd:COG2956  93 DRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAievlerLLKLGPENAHAYCELAELYLEQGDYD 161
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 68-207 2.45e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.30  E-value: 2.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50540514    68 ALLAEQDRNWEALKKWDEAVQLTPEDAVLYEMKSQVLITLGEVFLAVQSAEMATRLRPIWWEAWQTLGRAQLSLGEVELA 147
Cdd:TIGR02917 541 GLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKA 620

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 50540514   148 VRSFQVALHLHPSERPLWeedlnwaLKLRENQQSLREkasqVDEARRLLVEAPELKGDYD 207
Cdd:TIGR02917 621 VSSFKKLLALQPDSALAL-------LLLADAYAVMKN----YAKAITSLKRALELKPDNT 669
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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