NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|47576593|ref|NP_001001007|]
View 

olfactory receptor Olr1664 [Rattus norvegicus]

Protein Classification

family 2 olfactory receptor( domain architecture ID 11610423)

family 2 olfactory receptor is a G-protein coupled receptor (GPCR) that plays a central role in olfaction, the sense of smell; GPCRs transmit physiological signals from the outside of the cell to the inside via G proteins by binding to an extracellular agonist, which induces conformational changes that lead to the activation of heterotrimeric G proteins, which then bind to and activate numerous downstream effector proteins

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
25-294 6.76e-169

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 469.41  E-value: 6.76e-169
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  25 MPLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIF 104
Cdd:cd15947   1 MPLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 105 HFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVM 184
Cdd:cd15947  81 LWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 185 IKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSS 264
Cdd:cd15947 161 IKLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 47576593 265 SSSQDKNKLLSLFYSLVTPMLNPFIYTLRN 294
Cdd:cd15947 241 SYSQDQGKFISLFYTVVTPTLNPLIYTLRN 270
 
Name Accession Description Interval E-value
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
25-294 6.76e-169

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 469.41  E-value: 6.76e-169
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  25 MPLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIF 104
Cdd:cd15947   1 MPLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 105 HFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVM 184
Cdd:cd15947  81 LWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 185 IKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSS 264
Cdd:cd15947 161 IKLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 47576593 265 SSSQDKNKLLSLFYSLVTPMLNPFIYTLRN 294
Cdd:cd15947 241 SYSQDQGKFISLFYTVVTPTLNPLIYTLRN 270
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
35-305 1.24e-44

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 153.43  E-value: 1.24e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593    35 YVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHFLGATECIL 114
Cdd:pfam13853   5 YLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593   115 LAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMIKMSCANTAF 194
Cdd:pfam13853  85 LLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593   195 NI--AMLSIVGTFysLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVI--SMYVQPSSSSSQDK 270
Cdd:pfam13853 165 NNiyGLFVVTSTF--GIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIglSMVHRFGHNVPPLL 242
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 47576593   271 NKLLSLFYSLVTPMLNPFIYTLRNKDVKGAMRRFL 305
Cdd:pfam13853 243 QIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
 
Name Accession Description Interval E-value
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
25-294 6.76e-169

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 469.41  E-value: 6.76e-169
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  25 MPLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIF 104
Cdd:cd15947   1 MPLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 105 HFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVM 184
Cdd:cd15947  81 LWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 185 IKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSS 264
Cdd:cd15947 161 IKLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 47576593 265 SSSQDKNKLLSLFYSLVTPMLNPFIYTLRN 294
Cdd:cd15947 241 SYSQDQGKFISLFYTVVTPTLNPLIYTLRN 270
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
25-294 4.95e-140

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 396.47  E-value: 4.95e-140
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  25 MPLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIF 104
Cdd:cd13954   1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 105 HFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVM 184
Cdd:cd13954  81 FSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 185 IKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSS 264
Cdd:cd13954 161 LKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 47576593 265 SSSQDKNKLLSLFYSLVTPMLNPFIYTLRN 294
Cdd:cd13954 241 SYSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
27-301 3.42e-136

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 387.12  E-value: 3.42e-136
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHF 106
Cdd:cd15434   3 LSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALG 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMIK 186
Cdd:cd15434  83 LGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALIK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 187 MSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSSS 266
Cdd:cd15434 163 LACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSV 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47576593 267 SQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAM 301
Cdd:cd15434 243 SQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
25-301 2.97e-135

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 384.52  E-value: 2.97e-135
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  25 MPLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIF 104
Cdd:cd15432   1 MVLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 105 HFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVM 184
Cdd:cd15432  81 LGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 185 IKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSS 264
Cdd:cd15432 161 LKLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPS 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47576593 265 SSSQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAM 301
Cdd:cd15432 241 NSSHDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
27-301 2.02e-131

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 374.87  E-value: 2.02e-131
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHF 106
Cdd:cd15225   3 LFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMIK 186
Cdd:cd15225  83 LGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 187 MSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSSS 266
Cdd:cd15225 163 LACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSSY 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47576593 267 SQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAM 301
Cdd:cd15225 243 SPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
25-294 1.32e-125

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 359.90  E-value: 1.32e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  25 MPLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIF 104
Cdd:cd15230   1 VPLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 105 HFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVM 184
Cdd:cd15230  81 AVFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 185 IKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSS 264
Cdd:cd15230 161 LKLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 47576593 265 SSSQDKNKLLSLFYSLVTPMLNPFIYTLRN 294
Cdd:cd15230 241 SYSLDQDKVVSVFYTVVIPMLNPLIYSLRN 270
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
26-294 7.45e-122

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 350.42  E-value: 7.45e-122
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  26 PLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFH 105
Cdd:cd15237   2 LLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 106 FLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMI 185
Cdd:cd15237  82 ALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 186 KMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSS 265
Cdd:cd15237 162 KLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHST 241
                       250       260
                ....*....|....*....|....*....
gi 47576593 266 SSQDKNKLLSLFYSLVTPMLNPFIYTLRN 294
Cdd:cd15237 242 HSPDQDKMISVFYTIVTPMLNPLIYSLRN 270
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
27-301 4.78e-121

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 348.49  E-value: 4.78e-121
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHF 106
Cdd:cd15231   3 LFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMIK 186
Cdd:cd15231  83 FVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 187 MSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSSS 266
Cdd:cd15231 163 LSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGY 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47576593 267 SQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAM 301
Cdd:cd15231 243 SLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
12-303 5.59e-120

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 346.57  E-value: 5.59e-120
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  12 FILLGFSNYPWLEMPLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKS 91
Cdd:cd15410   1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  92 ISYRGCVTQFYIFHFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGN 171
Cdd:cd15410  81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 172 NKVDNFLCEVPVMIKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLF 251
Cdd:cd15410 161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 47576593 252 YGPVISMYVQPSSSSSQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAMRR 303
Cdd:cd15410 241 HGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRK 292
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
12-298 2.49e-119

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 344.69  E-value: 2.49e-119
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  12 FILLGFSNYPWLEMPLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKS 91
Cdd:cd15408   1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  92 ISYRGCVTQFYIFHFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGN 171
Cdd:cd15408  81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 172 NKVDNFLCEVPVMIKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLF 251
Cdd:cd15408 161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 47576593 252 YGPVISMYVQPSSSSSQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVK 298
Cdd:cd15408 241 YGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
12-305 4.72e-119

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 344.35  E-value: 4.72e-119
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  12 FILLGFSNYPWLEMPLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKS 91
Cdd:cd15943   2 FILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  92 ISYRGCVTQFYIFHFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGN 171
Cdd:cd15943  82 ISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCGS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 172 NKVDNFLCEVPVMIKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLF 251
Cdd:cd15943 162 NVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTIF 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 47576593 252 YGPVISMYVQPSSSSSQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAMRRFL 305
Cdd:cd15943 242 YGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRIL 295
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
25-294 1.77e-118

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 341.90  E-value: 1.77e-118
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  25 MPLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIF 104
Cdd:cd15431   1 IILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYIS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 105 HFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQStLTVKLPFCGNNKVDNFLCEVPVM 184
Cdd:cd15431  81 LFLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPV-LTMPLHFCGPNVINHFFCEVQAL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 185 IKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSS 264
Cdd:cd15431 160 LKLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQS 239
                       250       260       270
                ....*....|....*....|....*....|
gi 47576593 265 SSSQDKNKLLSLFYSLVTPMLNPFIYTLRN 294
Cdd:cd15431 240 KSSSDQDKIISVFYGVVTPMLNPLIYSLRN 269
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
26-294 7.02e-118

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 340.23  E-value: 7.02e-118
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  26 PLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFH 105
Cdd:cd15911   2 LLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 106 FLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMI 185
Cdd:cd15911  82 SLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 186 KMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSS 265
Cdd:cd15911 162 KLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTN 241
                       250       260
                ....*....|....*....|....*....
gi 47576593 266 SSQDKNKLLSLFYSLVTPMLNPFIYTLRN 294
Cdd:cd15911 242 TSRDLNKVFSLFYTVLTPLVNPLIYSLRN 270
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
26-301 2.20e-116

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 336.89  E-value: 2.20e-116
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  26 PLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFH 105
Cdd:cd15235   3 LLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFI 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 106 FLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMI 185
Cdd:cd15235  83 AFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLL 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 186 KMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSS 265
Cdd:cd15235 163 KLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSS 242
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47576593 266 SSQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAM 301
Cdd:cd15235 243 YSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
27-301 4.46e-115

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 333.60  E-value: 4.46e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHF 106
Cdd:cd15429   3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMIK 186
Cdd:cd15429  83 LGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVR 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 187 MSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSSS 266
Cdd:cd15429 163 LACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGS 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47576593 267 SQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAM 301
Cdd:cd15429 243 SALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
25-294 2.87e-113

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 328.67  E-value: 2.87e-113
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  25 MPLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIF 104
Cdd:cd15912   1 ILLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 105 HFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVM 184
Cdd:cd15912  81 FFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 185 IKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSS 264
Cdd:cd15912 161 LKLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQ 240
                       250       260       270
                ....*....|....*....|....*....|
gi 47576593 265 SSSQDKNKLLSLFYSLVTPMLNPFIYTLRN 294
Cdd:cd15912 241 SSSLDLNKVVALLNTVVTPLLNPFIYTLRN 270
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
27-303 3.13e-113

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 328.88  E-value: 3.13e-113
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHF 106
Cdd:cd15419   3 LFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMIK 186
Cdd:cd15419  83 FGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 187 MSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSSS 266
Cdd:cd15419 163 LSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAVS 242
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47576593 267 SQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAMRR 303
Cdd:cd15419 243 SPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
27-303 8.29e-113

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 327.68  E-value: 8.29e-113
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHF 106
Cdd:cd15417   3 LFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSG 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMIK 186
Cdd:cd15417  83 MGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLLS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 187 MSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSSS 266
Cdd:cd15417 163 LSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSSH 242
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47576593 267 SQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAMRR 303
Cdd:cd15417 243 SQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
27-301 2.16e-112

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 326.81  E-value: 2.16e-112
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHF 106
Cdd:cd15421   3 LFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMIK 186
Cdd:cd15421  83 LGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 187 MSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSSS 266
Cdd:cd15421 163 LSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYH 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47576593 267 SQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAM 301
Cdd:cd15421 243 SPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
27-294 3.03e-111

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 323.41  E-value: 3.03e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHF 106
Cdd:cd15918   3 LFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMIK 186
Cdd:cd15918  83 FGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 187 MSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSSS 266
Cdd:cd15918 163 LSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSH 242
                       250       260
                ....*....|....*....|....*...
gi 47576593 267 SQDKNKLLSLFYSLVTPMLNPFIYTLRN 294
Cdd:cd15918 243 SASKDSVAAVMYTVVTPMLNPFIYSLRN 270
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
25-303 3.16e-109

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 318.88  E-value: 3.16e-109
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  25 MPLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIF 104
Cdd:cd15411   1 VPLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 105 HFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVM 184
Cdd:cd15411  81 IALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 185 IKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSS 264
Cdd:cd15411 161 LKLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47576593 265 SSSQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAMRR 303
Cdd:cd15411 241 SYSLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
27-301 9.73e-108

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 315.04  E-value: 9.73e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHF 106
Cdd:cd15420   3 LFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMIK 186
Cdd:cd15420  83 LAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 187 MSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSSS 266
Cdd:cd15420 163 LACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSN 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47576593 267 SQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAM 301
Cdd:cd15420 243 SAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
27-301 2.66e-107

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 313.65  E-value: 2.66e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHF 106
Cdd:cd15433   3 LFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMIK 186
Cdd:cd15433  83 LGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 187 MSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSSS 266
Cdd:cd15433 163 LACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHRY 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47576593 267 SQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAM 301
Cdd:cd15433 243 SQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
25-301 6.05e-107

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 312.99  E-value: 6.05e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  25 MPLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIF 104
Cdd:cd15229   1 IFLFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 105 HFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVM 184
Cdd:cd15229  81 FFFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 185 IKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSS 264
Cdd:cd15229 161 LPLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNS 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47576593 265 SSSQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAM 301
Cdd:cd15229 241 ASSSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
28-294 8.06e-105

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 307.07  E-value: 8.06e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  28 FIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHFL 107
Cdd:cd15227   4 FVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 108 GATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMIKM 187
Cdd:cd15227  84 AASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 188 SCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSSSS 267
Cdd:cd15227 164 SCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSP 243
                       250       260
                ....*....|....*....|....*..
gi 47576593 268 QDKNKLLSLFYSLVTPMLNPFIYTLRN 294
Cdd:cd15227 244 SLLDLLLSVFYSVVPPTLNPIIYSLRN 270
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
27-294 1.69e-104

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 306.22  E-value: 1.69e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHF 106
Cdd:cd15430   3 LFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMIK 186
Cdd:cd15430  83 MGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 187 MSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSSS 266
Cdd:cd15430 163 LACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSKN 242
                       250       260
                ....*....|....*....|....*...
gi 47576593 267 SQDKNKLLSLFYSLVTPMLNPFIYTLRN 294
Cdd:cd15430 243 AQISDKLITLFYGVVTPMLNPIIYSLRN 270
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
12-303 5.01e-104

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 305.90  E-value: 5.01e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  12 FILLGFSNYPWLEMPLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKS 91
Cdd:cd15945   1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  92 ISYRGCVTQFYIFHFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGN 171
Cdd:cd15945  81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 172 NKVDNFLCEVPVMIKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLF 251
Cdd:cd15945 161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 47576593 252 YGPVISMYVQPSSSSSQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAMRR 303
Cdd:cd15945 241 YGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
25-294 5.62e-104

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 304.95  E-value: 5.62e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  25 MPLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIF 104
Cdd:cd15232   1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 105 HFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVM 184
Cdd:cd15232  81 TWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 185 IKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSS 264
Cdd:cd15232 161 LLLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 47576593 265 SSSQDKNKLLSLFYSLVTPMLNPFIYTLRN 294
Cdd:cd15232 241 SYSPEKDKVVAVLYSVVTPTLNPLIYSLRN 270
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
27-301 2.01e-103

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 303.97  E-value: 2.01e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHF 106
Cdd:cd15424   3 LFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMIK 186
Cdd:cd15424  83 LGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 187 MSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSSS 266
Cdd:cd15424 163 LACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGS 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47576593 267 SQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAM 301
Cdd:cd15424 243 TPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
26-301 9.99e-103

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 302.19  E-value: 9.99e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  26 PLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFH 105
Cdd:cd15234   2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 106 FLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMI 185
Cdd:cd15234  82 LFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 186 KMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSS 265
Cdd:cd15234 162 KLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVT 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47576593 266 SSQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAM 301
Cdd:cd15234 242 HSSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
25-303 1.00e-101

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 299.71  E-value: 1.00e-101
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  25 MPLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIF 104
Cdd:cd15409   1 VPLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 105 HFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVM 184
Cdd:cd15409  81 GFSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 185 IKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSS 264
Cdd:cd15409 161 LKISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47576593 265 SSSQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAMRR 303
Cdd:cd15409 241 LYALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
26-303 2.16e-101

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 298.93  E-value: 2.16e-101
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  26 PLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFH 105
Cdd:cd15412   2 LLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 106 FLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMI 185
Cdd:cd15412  82 ALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 186 KMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSS 265
Cdd:cd15412 162 KLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSE 241
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47576593 266 SSQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAMRR 303
Cdd:cd15412 242 ESVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
27-294 8.03e-101

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 296.91  E-value: 8.03e-101
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHF 106
Cdd:cd15915   3 LFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMIK 186
Cdd:cd15915  83 LGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 187 MSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRI-RSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSS 265
Cdd:cd15915 163 LACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKvRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSG 242
                       250       260
                ....*....|....*....|....*....
gi 47576593 266 SSQDKNKLLSLFYSLVTPMLNPFIYTLRN 294
Cdd:cd15915 243 DSLEQDRIVALLYTVVTPVLNPLIYTLRN 271
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
26-303 1.12e-100

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 296.97  E-value: 1.12e-100
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  26 PLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFH 105
Cdd:cd15416   2 ILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 106 FLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMI 185
Cdd:cd15416  82 TFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 186 KMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSS 265
Cdd:cd15416 162 KLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSS 241
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47576593 266 SSQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAMRR 303
Cdd:cd15416 242 YSMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
16-305 1.13e-99

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 295.05  E-value: 1.13e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  16 GFSNYPWLEMPLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYR 95
Cdd:cd15406   1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  96 GCVTQFYIFHFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVD 175
Cdd:cd15406  81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 176 NFLCEVPVMIKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPV 255
Cdd:cd15406 161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 47576593 256 ISMYVQPSSSSSQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAMRRFL 305
Cdd:cd15406 241 IFMYLKPSSSSSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKVL 290
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
26-303 3.91e-98

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 290.47  E-value: 3.91e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  26 PLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFH 105
Cdd:cd15415   2 PLFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 106 FLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMI 185
Cdd:cd15415  82 VFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 186 KMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSS 265
Cdd:cd15415 162 KLSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQ 241
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47576593 266 SSQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAMRR 303
Cdd:cd15415 242 YSLEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
25-303 3.77e-97

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 288.07  E-value: 3.77e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  25 MPLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIF 104
Cdd:cd15413   1 IPLFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 105 HFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVM 184
Cdd:cd15413  81 LTFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 185 IKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSS 264
Cdd:cd15413 161 LALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKS 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47576593 265 SSSQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAMRR 303
Cdd:cd15413 241 SHSLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
27-294 8.54e-97

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 286.87  E-value: 8.54e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHF 106
Cdd:cd15224   3 LFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMIK 186
Cdd:cd15224  83 LACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLN 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 187 MSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSSS 266
Cdd:cd15224 163 LSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAIS 242
                       250       260
                ....*....|....*....|....*...
gi 47576593 267 SQDKNKLLSLFYSLVTPMLNPFIYTLRN 294
Cdd:cd15224 243 SFDSNKLVSVLYTVVTPLLNPIIYCLRN 270
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
27-294 1.83e-96

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 285.64  E-value: 1.83e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHF 106
Cdd:cd15226   3 LFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMIK 186
Cdd:cd15226  83 FGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 187 MSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVlRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSSS 266
Cdd:cd15226 163 LACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTV-RKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTF 241
                       250       260
                ....*....|....*....|....*...
gi 47576593 267 SQDknKLLSLFYSLVTPMLNPFIYTLRN 294
Cdd:cd15226 242 PVD--KFLAVFYTVITPLLNPIIYTLRN 267
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
12-305 6.38e-96

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 285.53  E-value: 6.38e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  12 FILLGFSNYPWLEMPLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKS 91
Cdd:cd15944   1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  92 ISYRGCVTQFYIFHFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGN 171
Cdd:cd15944  81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 172 NKVDNFLCEVPVMIKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLF 251
Cdd:cd15944 161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 47576593 252 YGPVISMYVQPSSSSSQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAMRRFL 305
Cdd:cd15944 241 YGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
25-301 7.14e-96

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 284.76  E-value: 7.14e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  25 MPLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIF 104
Cdd:cd15428   1 ILLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 105 HFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVM 184
Cdd:cd15428  81 LSFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 185 IKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSS 264
Cdd:cd15428 161 LKLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKS 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47576593 265 SSSQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAM 301
Cdd:cd15428 241 STSKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
25-303 5.00e-95

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 282.78  E-value: 5.00e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  25 MPLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIF 104
Cdd:cd15414   1 IPLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 105 HFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVM 184
Cdd:cd15414  81 GLFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 185 IKMSCANTAFNIAML----SIVGTFYSLVplslILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYV 260
Cdd:cd15414 161 LSLSCADTQINKWVLfimaGALGVLSGLI----ILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYV 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 47576593 261 QPSSSSSQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAMRR 303
Cdd:cd15414 237 RPSSSSSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRR 279
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
27-294 1.42e-94

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 281.02  E-value: 1.42e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHF 106
Cdd:cd15939   3 CFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMIK 186
Cdd:cd15939  83 FGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 187 MSCANTaFNIAMLSIVGT-FYSLVPLSLILVSYGFIVATvLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSS 265
Cdd:cd15939 163 LACTDT-YVIGLLVVANSgLICLLSFLILLISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240
                       250       260
                ....*....|....*....|....*....
gi 47576593 266 SSQDknKLLSLFYSLVTPMLNPFIYTLRN 294
Cdd:cd15939 241 FPID--KVVAVFYTIITPMLNPLIYTLRN 267
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
25-294 2.77e-93

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 277.79  E-value: 2.77e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  25 MPLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIF 104
Cdd:cd15940   1 LAFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 105 HFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVM 184
Cdd:cd15940  81 HLFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 185 IKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATvLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSS 264
Cdd:cd15940 161 IKLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVS-LRKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPST 239
                       250       260       270
                ....*....|....*....|....*....|
gi 47576593 265 SSSQDknKLLSLFYSLVTPMLNPFIYTLRN 294
Cdd:cd15940 240 SFSED--KVVSVFYTVVTPLLNPIIYTLRN 267
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
26-301 2.85e-93

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 278.18  E-value: 2.85e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  26 PLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPD-KSISYRGCVTQFYIF 104
Cdd:cd15916   2 LLFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGgKVISFGGCVAQLYFF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 105 HFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVM 184
Cdd:cd15916  82 HFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 185 IKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSS 264
Cdd:cd15916 162 LKLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGS 241
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47576593 265 SSSQDknKLLSLFYSLVTPMLNPFIYTLRNKDVKGAM 301
Cdd:cd15916 242 KEALD--GVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
27-301 2.92e-93

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 278.16  E-value: 2.92e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHF 106
Cdd:cd15228   3 LFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMIK 186
Cdd:cd15228  83 LGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 187 MSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSSS 266
Cdd:cd15228 163 LACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPSP 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47576593 267 SQDknKLLSLFYSLVTPMLNPFIYTLRNKDVKGAM 301
Cdd:cd15228 243 VLV--TPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
27-294 5.76e-92

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 274.36  E-value: 5.76e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHF 106
Cdd:cd15946   3 LFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMIK 186
Cdd:cd15946  83 LGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 187 MSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSSS 266
Cdd:cd15946 163 LACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNY 242
                       250       260
                ....*....|....*....|....*...
gi 47576593 267 SQDKNKLLSLFYSLVTPMLNPFIYTLRN 294
Cdd:cd15946 243 SPERDKKISLFYNVFTALLNPVIYSLRN 270
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
27-294 1.01e-90

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 271.50  E-value: 1.01e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHF 106
Cdd:cd15913   3 LFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMIK 186
Cdd:cd15913  83 LGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 187 MSCANTAfniAMLSIVGTFYSLV---PLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPS 263
Cdd:cd15913 163 LSCVPAP---GTELICYTLSSLIifgTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPG 239
                       250       260       270
                ....*....|....*....|....*....|.
gi 47576593 264 SSSSQDKNKLLSLFYSLVTPMLNPFIYTLRN 294
Cdd:cd15913 240 SGNSTGMQKIVTLFYSVVTPLLNPLIYSLRN 270
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
27-294 1.21e-89

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 268.47  E-value: 1.21e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHF 106
Cdd:cd15914   3 LFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMIK 186
Cdd:cd15914  83 LGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 187 MSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSSS 266
Cdd:cd15914 163 LACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSY 242
                       250       260
                ....*....|....*....|....*...
gi 47576593 267 SQDKNKLLSLFYSLVTPMLNPFIYTLRN 294
Cdd:cd15914 243 SLDYDRAIAVVYAVLTPFFNPIIYSLRN 270
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
26-294 2.09e-89

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 268.05  E-value: 2.09e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  26 PLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFH 105
Cdd:cd15936   2 FLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 106 FLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMI 185
Cdd:cd15936  82 FTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 186 KMSCANT-AFNIAMLSIVGtFYSLVPLSLILVSYGFIVATvLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSS 264
Cdd:cd15936 162 KLACTDTfLLELLMVSNSG-LVTLLIFFILLISYTVILVK-IRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQ 239
                       250       260       270
                ....*....|....*....|....*....|
gi 47576593 265 SSSQDknKLLSLFYSLVTPMLNPFIYTLRN 294
Cdd:cd15936 240 TFPMD--KAVSVLYTVITPMLNPMIYTLRN 267
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
28-301 6.41e-89

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 267.02  E-value: 6.41e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  28 FIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHFL 107
Cdd:cd15236   4 FALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 108 GATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMIKM 187
Cdd:cd15236  84 GCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 188 SCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSSSS 267
Cdd:cd15236 164 SCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNS 243
                       250       260       270
                ....*....|....*....|....*....|....
gi 47576593 268 QDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAM 301
Cdd:cd15236 244 SDKDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
27-301 8.09e-89

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 266.66  E-value: 8.09e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHF 106
Cdd:cd15233   3 LFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMIK 186
Cdd:cd15233  83 LAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQ 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 187 MSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSSS 266
Cdd:cd15233 163 LSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVY 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47576593 267 SQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAM 301
Cdd:cd15233 243 SSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
27-303 1.26e-88

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 266.26  E-value: 1.26e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHF 106
Cdd:cd15418   4 LFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAG 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMIK 186
Cdd:cd15418  84 LAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLVK 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 187 MSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSSS 266
Cdd:cd15418 164 LACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPSSSH 243
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47576593 267 SQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAMRR 303
Cdd:cd15418 244 TPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKK 280
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
25-303 3.53e-87

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 262.74  E-value: 3.53e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  25 MPLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIF 104
Cdd:cd15407   1 IPLFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 105 HFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVM 184
Cdd:cd15407  81 VVFATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 185 IKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSS 264
Cdd:cd15407 161 LALSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47576593 265 SSSQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAMRR 303
Cdd:cd15407 241 SHSMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
25-301 2.57e-85

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 257.73  E-value: 2.57e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  25 MPLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIF 104
Cdd:cd15405   1 IPLFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 105 HFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVM 184
Cdd:cd15405  81 CFFVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 185 IKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSS 264
Cdd:cd15405 161 LQLSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47576593 265 SSSQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAM 301
Cdd:cd15405 241 VGSVNQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
27-301 2.90e-85

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 257.85  E-value: 2.90e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDS-PMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPD-KSISYRGCVTQFYIF 104
Cdd:cd15941   3 FFLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQLYAF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 105 HFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVM 184
Cdd:cd15941  83 HFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 185 IKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSS 264
Cdd:cd15941 163 LKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSS 242
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47576593 265 SSSQDknKLLSLFYSLVTPMLNPFIYTLRNKDVKGAM 301
Cdd:cd15941 243 SQAGA--GAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
26-301 2.48e-83

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 252.74  E-value: 2.48e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  26 PLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFH 105
Cdd:cd15942   2 PLFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 106 FLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMI 185
Cdd:cd15942  82 FLGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAML 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 186 KMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSS 265
Cdd:cd15942 162 KLACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQ 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47576593 266 SSQDknKLLSLFYSLVTPMLNPFIYTLRNKDVKGAM 301
Cdd:cd15942 242 DPLD--GVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
27-294 8.65e-81

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 245.83  E-value: 8.65e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQL-DSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFH 105
Cdd:cd15935   3 LFVLVLACYAAILLGNLLIVVTVHADPHLlQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLH 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 106 FLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMI 185
Cdd:cd15935  83 FLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVI 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 186 KMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATvLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSS 265
Cdd:cd15935 163 KLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTT-LRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSS 241
                       250       260
                ....*....|....*....|....*....
gi 47576593 266 SSQDknKLLSLFYSLVTPMLNPFIYTLRN 294
Cdd:cd15935 242 SSVD--KVASVFYTLITPALNPLIYTLRN 268
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
27-294 1.20e-80

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 245.55  E-value: 1.20e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHF 106
Cdd:cd15938   3 LFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMIK 186
Cdd:cd15938  83 VGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 187 MSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIvatVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSSS 266
Cdd:cd15938 163 LACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTI---LVTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTF 239
                       250       260
                ....*....|....*....|....*...
gi 47576593 267 SQDknKLLSLFYSLVTPMLNPFIYTLRN 294
Cdd:cd15938 240 PVD--KHVSVLYNVITPMLNPLIYTLRN 265
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
27-294 2.83e-74

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 229.24  E-value: 2.83e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHF 106
Cdd:cd15937   3 LFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMIK 186
Cdd:cd15937  83 LGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVIK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 187 MSCANT-AFNIAMLSIVGtFYSLVPLSLILVSYGFIVATvLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSS 265
Cdd:cd15937 163 LACTNTyTVELLMFSNSG-LVILLCFLLLLISYAFLLAK-LRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRS 240
                       250       260
                ....*....|....*....|....*....
gi 47576593 266 SSQDknKLLSLFYSLVTPMLNPFIYTLRN 294
Cdd:cd15937 241 FPMD--KVVAVFHTVIFPLLNPMIYTLRN 267
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
21-301 2.30e-69

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 217.16  E-value: 2.30e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  21 PWLEMPLFIMVLVAyvctVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQ 100
Cdd:cd15223   1 HWLSLPFLLLYLVA----LVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQ 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 101 FYIFHFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCI-LLMFMTWLSGLAnSLLQSTLTVKLPFCGNNKVDNFLC 179
Cdd:cd15223  77 MFFIHFFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILkLVLFALIRSGLL-VLPIVVLASQLSYCSSNVIEHCYC 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 180 EVPVMIKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFY--GPVIS 257
Cdd:cd15223 156 DHMALVSLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYtaVLVSS 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 47576593 258 MYVQPSSSSSQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAM 301
Cdd:cd15223 236 LTYRFGKTIPPDVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
22-297 6.81e-61

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 195.33  E-value: 6.81e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  22 WLEMPLFIMvlvaYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQF 101
Cdd:cd15950   2 WIAIPFCSM----YVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQM 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 102 YIFHFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEV 181
Cdd:cd15950  78 FFVHSFTAVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEH 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 182 PVMIKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGP-VISMYV 260
Cdd:cd15950 158 MAVVKLACADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPgLLSIYT 237
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47576593 261 QP-SSSSSQDKNKLLSLFYSLVTPMLNPFIYTLRNKDV 297
Cdd:cd15950 238 QRfGQGVPPHTQVLLADLYLLVPPMLNPIIYGMRTKQI 275
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
22-295 1.61e-60

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 194.43  E-value: 1.61e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  22 WLEMPLFIMVLVAyvctVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQF 101
Cdd:cd15917   2 WLSIPFCAMYLVA----LLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQM 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 102 YIFHFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEV 181
Cdd:cd15917  78 FFIHSFTAMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEH 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 182 PVMIKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQ 261
Cdd:cd15917 158 MAVVKLACGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLT 237
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47576593 262 PSSSSSQDKNK--LLSLFYSLVTPMLNPFIYTLRNK 295
Cdd:cd15917 238 HRFGHHVPPHVhiLLANLYLLLPPMLNPIVYGVRTK 273
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
21-295 4.35e-57

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 185.40  E-value: 4.35e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  21 PWLEMPLFIMvlvaYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQ 100
Cdd:cd15222   1 HWISIPFCLL----YLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQ 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 101 FYIFHFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLmfmtwlsGLAnSLLQSTLTV--------KLPFCGNN 172
Cdd:cd15222  77 MFFIHTFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKI-------GLA-IVLRSVLLLlplpfllkRLPFCHSN 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 173 KVDNFLCEVPVMIKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFY 252
Cdd:cd15222 149 VLSHSYCLHQDVMKLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFY 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 47576593 253 GPVI--SMYVQPSSSSSQDKNKLLSLFYSLVTPMLNPFIYTLRNK 295
Cdd:cd15222 229 VPMIglSMVHRFGKHASPLVHVLMANVYLLVPPVLNPIIYSVKTK 273
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
22-295 8.02e-56

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 182.10  E-value: 8.02e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  22 WLEMPLFIMVLVAyvctVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQF 101
Cdd:cd15221   2 WISIPFCSMYIVA----LLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQM 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 102 YIFHFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEV 181
Cdd:cd15221  78 FFVHFVFVTESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEH 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 182 PVMIKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPV------ 255
Cdd:cd15221 158 MGIARLACADITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAffsflt 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 47576593 256 ------ISMYVQpsssssqdknKLLSLFYSLVTPMLNPFIYTLRNK 295
Cdd:cd15221 238 hrfgrhIPRHVH----------ILLANLYVLVPPMLNPIVYGVKTK 273
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
22-295 1.57e-54

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 179.00  E-value: 1.57e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  22 WLEMPLFIMvlvaYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQF 101
Cdd:cd15953   2 WISIPFCLM----YIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQM 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 102 YIFHFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEV 181
Cdd:cd15953  78 FFIHTLSIMESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEH 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 182 PVMIKMSCANTAFN-----IAMLSIVGtfyslVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVI 256
Cdd:cd15953 158 MAVVKLACGDTTINriyglVVALLVVG-----LDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPAL 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 47576593 257 --SMYVQPSSSSSQDKNKLLSLFYSLVTPMLNPFIYTLRNK 295
Cdd:cd15953 233 fsFLTHRFGQGIAPHIHIILANLYLLVPPMLNPIIYGVKTK 273
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
22-297 6.76e-54

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 177.19  E-value: 6.76e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  22 WLEMPLFIMVLVAyvctVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQF 101
Cdd:cd15952   2 WIGFPFCAVYLIA----LLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQM 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 102 YIFHFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEV 181
Cdd:cd15952  78 FFIHTFTGMESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEH 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 182 PVMIKMSCANTAFNIAMLSIVGTFYSLvPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYV- 260
Cdd:cd15952 158 MGIAKLACASIRINIIYGLFAISVLVL-DVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLt 236
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47576593 261 -QPSSSSSQDKNKLLSLFYSLVTPMLNPFIYTLRNKDV 297
Cdd:cd15952 237 hRFGHNIPRYIHILLANLYVVLPPMLNPVIYGVRTKQI 274
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
22-297 1.65e-50

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 168.68  E-value: 1.65e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  22 WLEMPLFIMVLVAyvctVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQF 101
Cdd:cd15951   2 WISIPFCIMYAVA----LLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQM 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 102 YIFHFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEV 181
Cdd:cd15951  78 FFIHSFSTMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEH 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 182 PVMIKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVI--SMY 259
Cdd:cd15951 158 MAVVKLACADTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALfsFLT 237
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47576593 260 VQPSSSSSQDKNKLLSLFYSLVTPMLNPFIYTLRNKDV 297
Cdd:cd15951 238 HRFGHNVPPHVHILIANVYLLVPPMLNPIIYGVRTKQI 275
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
20-298 5.26e-48

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 162.00  E-value: 5.26e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  20 YPWLEMPLFIMVLVAyvctVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVT 99
Cdd:cd15948   1 HPWISIPFCSAFTVA----LLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLV 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 100 QFYIFHFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQfcilLMFMTWLSGLANSLLQST----LTVKLPFCGNNKVD 175
Cdd:cd15948  77 QMFFLHSFSIMESAVLLAMAFDRYVAICNPLRYATILTNS----VITKIGLAALARAVTLMTplpfLLRRLPYCRSHVIA 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 176 NFLCEVPVMIKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPV 255
Cdd:cd15948 153 HCYCEHMAVVKLACGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPV 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 47576593 256 I--SMYVQPSSSSSQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVK 298
Cdd:cd15948 233 VlsSTMHRFARHVAPHVHILLANFYLLFPPMMNPIVYGVKTKQIR 277
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
35-305 1.24e-44

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 153.43  E-value: 1.24e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593    35 YVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHFLGATECIL 114
Cdd:pfam13853   5 YLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593   115 LAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVMIKMSCANTAF 194
Cdd:pfam13853  85 LLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593   195 NI--AMLSIVGTFysLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVI--SMYVQPSSSSSQDK 270
Cdd:pfam13853 165 NNiyGLFVVTSTF--GIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIglSMVHRFGHNVPPLL 242
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 47576593   271 NKLLSLFYSLVTPMLNPFIYTLRNKDVKGAMRRFL 305
Cdd:pfam13853 243 QIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
22-297 1.57e-44

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 153.10  E-value: 1.57e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  22 WLEMPLFIMvlvaYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQF 101
Cdd:cd15956   2 WLSLPFCFI----YVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQM 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 102 YIFHFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEV 181
Cdd:cd15956  78 FLVHAFSAMESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEH 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 182 PVMIKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYV- 260
Cdd:cd15956 158 MAVVKLACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLm 237
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47576593 261 -QPSSSSSQDKNKLLSLFYSLVTPMLNPFIYTLRNKDV 297
Cdd:cd15956 238 hRFGHSVPSAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
9-298 1.26e-42

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 148.39  E-value: 1.26e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593   9 PKIFILLGF----SNYPWLEMPLFIMVLVAyvctVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRN 84
Cdd:cd15949   1 PSTFILLGIpglePLHVWISIPFCSMYLIA----VLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAI 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  85 LWGPDKSISYRGCVTQFYIFHFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTV 164
Cdd:cd15949  77 FWFSSNEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVR 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 165 KLPFCGNNKVDNFLCEVPVMIKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSH 244
Cdd:cd15949 157 RLPWYRTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSH 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 47576593 245 VVVVTLFYGPVI--SMYVQPSSSSSQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVK 298
Cdd:cd15949 237 VCAILAFYVPIAvsSLIHRFGQNVPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
41-290 1.56e-40

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 142.05  E-value: 1.56e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593    41 GNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIP-QLLRNLWGPDKSISYRGCVTQFYIFHFLGATECILLAVMS 119
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPfWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593   120 LDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNkvdNFLCEVPVMIKMSCANTafnIAML 199
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGN---VTVCFIDFPEDLSKPVS---YTLL 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593   200 SIVGTFYslVPLSLILVSYGFIVATVLRIRSSEG-------KKKAFNTCGSHVVVVTLFYGPVISMYVQPS------SSS 266
Cdd:pfam00001 155 ISVLGFL--LPLLVILVCYTLIIRTLRKSASKQKssertqrRRKALKTLAVVVVVFILCWLPYHIVNLLDSlaldceLSR 232
                         250       260
                  ....*....|....*....|....
gi 47576593   267 SQDKNKLLSLFYSLVTPMLNPFIY 290
Cdd:pfam00001 233 LLDKALSVTLWLAYVNSCLNPIIY 256
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
22-297 3.00e-37

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 134.18  E-value: 3.00e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  22 WLEMPLFIMVLVAyvctVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQF 101
Cdd:cd15954   2 WISIPFCFMYIIA----MVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQM 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 102 YIFHFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEV 181
Cdd:cd15954  78 FFVHTFTGMESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDH 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 182 PVMIKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQ 261
Cdd:cd15954 158 MSVVKLACANIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFA 237
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47576593 262 PSSSSSQDKNK---LLSLFYSLVTPMLNPFIYTLRNKDV 297
Cdd:cd15954 238 HRFGGHHITPHihiIMANLYLLLPPMMNPIVYGVKTKQI 276
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
22-297 2.62e-36

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 131.43  E-value: 2.62e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  22 WLEMPLFIMVLVAyvctVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQF 101
Cdd:cd15955   2 WIGIPFCIMFLLA----VLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQM 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 102 YIFHFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVK-LPFCGNNKVDNFLCE 180
Cdd:cd15955  78 FFIHTLQAFESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPLLIKLrLHHFRSTVISHSYCE 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 181 VPVMIKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFY-------- 252
Cdd:cd15955 158 HMAVVKLAADDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYtlaffsff 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 47576593 253 ----GPVISMYVqpsssssqdkNKLLSLFYSLVTPMLNPFIYTLRNKDV 297
Cdd:cd15955 238 ahrfGHHVAPYV----------HILLSNLYLLVPPVLNPIVYGVKTKQI 276
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
27-294 1.13e-24

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 100.44  E-value: 1.13e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHF 106
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLlqstltvkLPFCGNNKVDNFLCevPVMIK 186
Cdd:cd00637  81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLAL--------PPLLGWGVYDYGGY--CCCCL 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 187 MSCANTAFNIAMLSIVGTFYsLVPLSLILVSYGFIVATVLR--------------IRSSEGKKKAFNTCGSHVVVVTLFY 252
Cdd:cd00637 151 CWPDLTLSKAYTIFLFVLLF-LLPLLVIIVCYVRIFRKLRRhrrrirssssnssrRRRRRRERKVTKTLLIVVVVFLLCW 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 47576593 253 GPVISMYVQPSSSSSQDKN----KLLSLFYSLVTPMLNPFIYTLRN 294
Cdd:cd00637 230 LPYFILLLLDVFGPDPSPLprilYFLALLLAYLNSAINPIIYAFFN 275
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
36-301 1.95e-15

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 74.52  E-value: 1.95e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  36 VCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIP----QLLRNLWGPDKSISYrgcvtqFYI-FHFLGAT 110
Cdd:cd14967  11 LVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPfsavYTLLGYWPFGPVLCR------FWIaLDVLCCT 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 111 ECIL-LAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLtvklpfcgnnkvDNFLCEVPVMIKMSC 189
Cdd:cd14967  85 ASILnLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVG------------WRDETQPSVVDCECE 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 190 ANTAFNIAMLSIVGTFYslVPLSLILVSYGFIVATVLRirssegKKKAFNTCGSHVVVVTLFYGPVISMY-VQPSSSSSQ 268
Cdd:cd14967 153 FTPNKIYVLVSSVISFF--IPLLIMIVLYARIFRVARR------ELKAAKTLAIIVGAFLLCWLPFFIIYlVSAFCPPDC 224
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47576593 269 DKNKLLSLFYSL--VTPMLNPFIYTLRNKDVKGAM 301
Cdd:cd14967 225 VPPILYAVFFWLgyLNSALNPIIYALFNRDFRRAF 259
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
28-301 1.55e-14

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 72.62  E-value: 1.55e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  28 FIMVLVAyVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQL----LRNLWgpdkSISYRGCVTQFYI 103
Cdd:cd14969   5 VYLSLIG-VLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSfysnLSGRW----SFGDPGCVIYGFA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 104 FHFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFmTWLSGLANSLlqstltvkLPFCGNNKVdnflceVPV 183
Cdd:cd14969  80 VTFLGLVSISTLAALAFERYLVIVRPLKAFRLSKRRALILIAF-IWLYGLFWAL--------PPLFGWSSY------VPE 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 184 MIKMSCA---------NTAFNIAMLsivgTFYSLVPLSLILVSYGFIVATV--------LRIRSSEGK------KKAFNT 240
Cdd:cd14969 145 GGGTSCSvdwyskdpnSLSYIVSLF----VFCFFLPLAIIIFCYYKIYRTLrkmskraaRRKNSAITKrtkkaeKKVAKM 220
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 241 CGSHVVVVTLFYGP--VISMYVqpssssSQDKNKLLSLFYSLVTPML-------NPFIYTLRNKDVKGAM 301
Cdd:cd14969 221 VLVMIVAFLIAWTPyaVVSLYV------SFGGESTIPPLLATIPALFaksstiyNPIIYVFMNKQFRRAL 284
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
26-301 7.53e-12

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 64.77  E-value: 7.53e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  26 PLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFH 105
Cdd:cd15012   1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 106 FLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSllqstlTVKLPFCGNNKVDNFLCEVPVMI 185
Cdd:cd15012  81 LSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYN------TPYFVFSQTVEILVTQDGQEEEI 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 186 kmSCANTAFNIAMLSIVGTF--YSLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPvisMYVQPS 263
Cdd:cd15012 155 --CVLDREMFNSKLYDTINFivWYLIPLLIMTVLYSKISIVLWKSSSIEARRKVVRLLVAVVVSFALCNLP---YHARKM 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 47576593 264 SSSSQDKNKLLSLFYSLVTPM----------LNPFIYTLRNKDVKGAM 301
Cdd:cd15012 230 WQYWSEPYRCDSNWNALLTPLtflvlyfnsaVNPLLYAFLSKRFRQSM 277
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
29-298 3.03e-10

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 59.86  E-value: 3.03e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  29 IMVLVAYVCT-VVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQL----LRNLWGPDKSISyRGCVTQFYI 103
Cdd:cd15215   3 SVLIVIFLCAsLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWViatsVPLFWPLDSHLC-TALVVLMHL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 104 FHFLGATECIllaVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSglanSLLQSTltvkLPFCGNNKVD----NFLC 179
Cdd:cd15215  82 FAFAGVNTIV---VVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIV----SVLQST----PPLYGWGQAAfderNALC 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 180 EVpvmikmsCANTAFNIAMLSIVGTFysLVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVvvvtLFYGPVISMY 259
Cdd:cd15215 151 SV-------IWGSSYSYTILSVVSSF--VLPVIIMLACYSMVFRAARRCYHCKAAKVIFIIIFSYV----LSMGPYSFLS 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 47576593 260 VQPSSSSSQDKNKLLSLFYSL--VTPMLNPFIYTLRNKDVK 298
Cdd:cd15215 218 VLAVWVDTQVPQWVISIILWLffLQCCIHPYIYGYMHKSIK 258
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
29-305 1.06e-08

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 55.34  E-value: 1.06e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  29 IMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHFLG 108
Cdd:cd15307   5 LLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 109 ATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPfcgNNKVDNFLCEVPVmikms 188
Cdd:cd15307  85 TASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKDH---ASVLVNGTCQIPD----- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 189 cantafniAMLSIVGT---FYslVPLSLILVSYGFIVATVLRIRSSEGK-----KKAFNTCGSHVVVVTLFYGPVISMYV 260
Cdd:cd15307 157 --------PVYKLVGSivcFY--IPLGVMLLTYCLTVRLLARQRSRHGRiirleQKATKVLGVVFFTFVILWSPFFVLNL 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 47576593 261 QPSSSSSQDKnKLLSLFYSLVT------PMLNPFIYTLRNKDVKGAMRRFL 305
Cdd:cd15307 227 LPTVCAECEE-RISHWVFDVVTwlgyasSMVNPIFYTIFNKVFRQAFKKVL 276
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
39-300 1.63e-08

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 54.51  E-value: 1.63e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  39 VVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIP--------------QLLRNLWGPdksisyrgcvtqfyiF 104
Cdd:cd15325  15 VLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPfsaifeilgywafgRVFCNIWAA---------------V 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 105 HFLGATECIL-LAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLlqstltvkLPFCGNNKV---DNFLCE 180
Cdd:cd15325  80 DVLCCTASIMsLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISI--------GPLFGWKEPapeDETICQ 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 181 VpvmikmscaNTAFNIAMLSIVGTFYslVPLSLILVSYGFIVATVLRIRSsegKKKAFNTCGSHVVVVTLFYGPVisMYV 260
Cdd:cd15325 152 I---------TEEPGYALFSALGSFY--LPLAIILVMYCRVYVVALKFSR---EKKAAKTLGIVVGCFVLCWLPF--FLV 215
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 47576593 261 QPSSSSSQDKNKLLSLF-----YSLVTPMLNPFIYTLRNKDVKGA 300
Cdd:cd15325 216 MPIGSIFPAYKPSDTVFkitfwLGYFNSCINPIIYPCSSQEFKKA 260
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
30-300 1.94e-08

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 54.51  E-value: 1.94e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  30 MVLVAYVC-TVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIP----QLLRNLWgpdksISYRGCVTQFYIF 104
Cdd:cd15326   5 LVLGAFILfAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPfsatLEILGYW-----VFGRIFCDIWAAV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 105 HFLGATECIL-LAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSlLQSTLTVKLPFCGNNKVdnflCEVpv 183
Cdd:cd15326  80 DVLCCTASILsLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVIS-IGPLLGWKEPAPPDDKV----CEI-- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 184 mikmscaNTAFNIAMLSIVGTFYslVPLSLILVSYGFIVATVLRIRSsegKKKAFNTCGSHVVVVTLFYGP-VISMYVQP 262
Cdd:cd15326 153 -------TEEPFYALFSSLGSFY--IPLIVILVMYCRVYIVALKFSR---EKKAAKTLGIVVGMFILCWLPfFIALPLGS 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 47576593 263 SSSSSQDKNKLLSLFYSL--VTPMLNPFIYTLRNKDVKGA 300
Cdd:cd15326 221 LFSHLKPPETLFKIIFWLgyFNSCLNPIIYPCSSKEFKRA 260
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
38-300 3.93e-08

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 53.26  E-value: 3.93e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  38 TVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPqllrnlwgpdksISYRGCVTQFYIF-----------HF 106
Cdd:cd15062  14 AIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLP------------FSATLEVLGYWAFgrifcdvwaavDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECIL-LAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSL-----LQSTLTVKLPFCGNNKVDNFlce 180
Cdd:cd15062  82 LCCTASIMsLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIgpllgWKEPAPADEQACGVNEEPGY--- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 181 vpvmikmscantafniAMLSIVGTFYslVPLSLILVSYGFIVATVLRIRSsegKKKAFNTCGSHVVVVTLFYGP-VISMY 259
Cdd:cd15062 159 ----------------VLFSSLGSFY--LPLAIILVMYCRVYVVAFKFSR---EKKAAKTLGIVVGAFVLCWFPfFVVLP 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 47576593 260 VQPSSSSSQDKNKLLSLFYSL--VTPMLNPFIYTLRNKDVKGA 300
Cdd:cd15062 218 LGSLFSTLKPPEPVFKVVFWLgyFNSCLNPIIYPCSSREFKRA 260
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
31-300 5.53e-08

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 53.03  E-value: 5.53e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  31 VLVAyVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPdkSISYRGCV---------TQF 101
Cdd:cd14968   8 VLIA-VLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILISLGL--PTNFHGCLfmaclvlvlTQS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 102 YIFHflgateciLLAVmSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLlqstltvkLPFCGNNKvDNFLCEV 181
Cdd:cd14968  85 SIFS--------LLAI-AIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGL--------TPMFGWNN-GAPLESG 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 182 PVMIKMSCANTAFnIAMLSIVgtFYS-----LVPLSLILVSYGFI--------VATVLRIRSSEGKK---KAFNTCGSHV 245
Cdd:cd14968 147 CGEGGIQCLFEEV-IPMDYMV--YFNffacvLVPLLIMLVIYLRIfrvirkqlRQIESLLRSRRSRStlqKEVKAAKSLA 223
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 246 VVVTLFygpVIS----------MYVQPsssssqDKNKLLSLFY-----SLVTPMLNPFIYTLRNKDVKGA 300
Cdd:cd14968 224 IILFLF---ALCwlplhiinciTLFCP------ECKVPKILTYiaillSHANSAVNPIVYAYRIRKFRQT 284
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
33-232 1.99e-07

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 51.52  E-value: 1.99e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  33 VAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPD---------KSISYrgcvTQFYI 103
Cdd:cd14997   9 VIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWAREpwllgefmcKLVPF----VELTV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 104 FHflgATECILLAVmSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVPv 183
Cdd:cd14997  85 AH---ASVLTILAI-SFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFITEFKEEDFNDGTPVAVCRTP- 159
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 47576593 184 mikmscANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIRSSE 232
Cdd:cd14997 160 ------ADTFWKVAYILSTIVVFFVVPLAILSGLYSVICRRLVGHPALE 202
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
29-243 2.20e-07

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 51.56  E-value: 2.20e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  29 IMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCvtQFYIF--HF 106
Cdd:cd15083   5 IFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGC--DMYGFsgGL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECILLAVMSLDRYIAICKPLRYPAIM-HQQFCILLMFmTWLSGLANSLLqstltvklPFCGNNKVdnflceVPVMI 185
Cdd:cd15083  83 FGIMSINTLAAIAVDRYLVITRPMKASVRIsHRRALIVIAV-VWLYSLLWVLP--------PLFGWSRY------VLEGL 147
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47576593 186 KMSC-----ANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVlriRSSEGKKKAFNTCGS 243
Cdd:cd15083 148 LTSCsfdylSRDDANRSYVICLLIFGFVLPLLIIIYCYSFIFRAV---RRHEKAMKEMAKRFS 207
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
29-305 2.97e-07

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 51.06  E-value: 2.97e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  29 IMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIP-QLLRNLWGPDKSISYRGCVTQFYIFHFL 107
Cdd:cd15305   5 LLILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPvSLIAILYDYAWPLPRYLCPIWISLDVLF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 108 GATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLAnsllqstLTVKLPFCGNNKvdnflcEVPVMIKM 187
Cdd:cd15305  85 STASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIG-------ISMPIPVIGLQD------DEKVFVNG 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 188 SCantAFNIAMLSIVGTFYS-LVPLSLILVSYGFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVI---SMYVQPS 263
Cdd:cd15305 152 TC---VLNDENFVLIGSFVAfFIPLIIMVITYCLTIQVLQRQQAINNERRASKVLGIVFFLFLIMWCPFFitnILSVLCK 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 47576593 264 SSSSQD-KNKLLSLFY--SLVTPMLNPFIYTLRNKDVKGAMRRFL 305
Cdd:cd15305 229 EACDQKlMEELLNVFVwvGYVSSGINPLVYTLFNKTYRRAFSNYI 273
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
41-159 3.37e-07

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 50.97  E-value: 3.37e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  41 GNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTT-TTIPQLLRNL----WGPD---KSISYRGCVTQFyifhflgaTEC 112
Cdd:cd15387  17 GNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVfQVLPQLIWDItfrfYGPDflcRLVKYLQVVGMF--------AST 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 47576593 113 ILLAVMSLDRYIAICKPLRYpaiMHQQFCILLMFMTWLSGLANSLLQ 159
Cdd:cd15387  89 YMLLLMSIDRCLAICQPLRS---LHRRSDRVYVLFSWLLSLVFSIPQ 132
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
29-246 6.74e-07

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 50.07  E-value: 6.74e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  29 IMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTI-PQLL---RNLW-GPD---KSISYRGCVTq 100
Cdd:cd14986   5 AVLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVlTQIIweaTGEWvAGDvlcRIVKYLQVVG- 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 101 fyifhfLGATECILLAvMSLDRYIAICKPLRYPAimHQQFCILLMFMTWLSGLANSLLQSTLTVKLpfcgnnkvdnflcE 180
Cdd:cd14986  84 ------LFASTYILVS-MSLDRYQAIVKPMSSLK--PRKRARLMIVVAWVLSFLFSIPQLVIFVER-------------E 141
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 181 VPVMIKM--SCANTAFNIAMLSIVGTFYSLV-PLSLILVSYGFIVATV-LRIRSSEGKKKAFNTCGSHVV 246
Cdd:cd14986 142 LGDGVHQcwSSFYTPWQRKVYITWLATYVFViPLIILSYCYGRILRTIwIRSRQKTDRPIAPTAMSCRSV 211
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
29-295 1.46e-06

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 48.86  E-value: 1.46e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  29 IMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIP----QLLRNLW--GPDKsisyrgCVTQFY 102
Cdd:cd15049   5 IATGSLSLVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNlytvYLVMGYWplGPLL------CDLWLA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 103 IFHFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLansLLQSTLTVKLP-FCGNNKVDNFLCEV 181
Cdd:cd15049  79 LDYVASNASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISF---VLWAPAILGWQyFVGERTVPDGQCYI 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 182 PVMikmscANTAFNIAmlSIVGTFYslVPLSLILVSYGFIVATVLRirssegKKKAFNTCGSHVVVVTLFYGPVISMYVQ 261
Cdd:cd15049 156 QFL-----DDPAITFG--TAIAAFY--LPVLVMTILYWRIYRETAR------ERKAARTLSAILLAFIITWTPYNILVLV 220
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47576593 262 PSSSSSQDKNKLLSLFYSL--VTPMLNPFIYTLRNK 295
Cdd:cd15049 221 STFCAKCIPDTLWSFGYWLcyINSTINPFCYALCNK 256
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
27-300 3.18e-06

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 47.69  E-value: 3.18e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVayVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIP-QLLRNLWGPDKSISYRGCVTQFYIFH 105
Cdd:cd15052   5 LLLLLLV--IATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPlSILTELFGGVWPLPLVLCLLWVTLDV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 106 FLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLAnsllqstLTVKLPFCGNNKVDNFLCEVPVMI 185
Cdd:cd15052  83 LFCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIG-------ISSPIPVLGIIDTTNVLNNGTCVL 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 186 kmscANTAFniamlSIVGTFYS-LVPLSLILVSYGfivatvLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSS 264
Cdd:cd15052 156 ----FNPNF-----VIYGSIVAfFIPLLIMVVTYA------LTIRLLSNEQKASKVLGIVFAVFVICWCPFFITNILTGL 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 47576593 265 SSSQDKN---KLLSLFYSL--VTPMLNPFIYTLRNKDVKGA 300
Cdd:cd15052 221 CEECNCRispWLLSVFVWLgyVSSTINPIIYTIFNKTFRRA 261
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
29-232 3.39e-06

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 47.65  E-value: 3.39e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  29 IMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTT----TIPQLLRNLWgpdkSISYRGCvtQFYIF 104
Cdd:cd15074   5 IYLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFgyplAIISAFAHRW----LFGDIGC--VFYGF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 105 --HFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFmTWLSGLansllqstLTVKLPFCGNNKVdnflceVP 182
Cdd:cd15074  79 cgFLFGCCSINTLTAISIYRYLKICHPPYGPKLSRRHVCIVIVA-IWLYAL--------FWAVAPLVGWGSY------GP 143
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 47576593 183 VMIKMSC-----------ANTAFNIAMLsivgTFYSLVPLSLILVSYGFIVATVLRIRSSE 232
Cdd:cd15074 144 EPFGTSCsidwtgasasvGGMSYIISIF----IFCYLLPVLIIVFSYVKIIRKVKSSRKRV 200
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
27-150 3.77e-06

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 47.35  E-value: 3.77e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHF 106
Cdd:cd15067   2 LGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGGYWLFGRDWCDVWHSFDV 81
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 47576593 107 LGATECIL-LAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWL 150
Cdd:cd15067  82 LASTASILnLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWI 126
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
29-305 6.26e-06

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 46.75  E-value: 6.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  29 IMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIP-QLLRNLWGPDKSISYRGCVTQFYIFHFL 107
Cdd:cd15306   5 LLILMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPiALLTILFEAMWPLPLVLCPIWLFLDVLF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 108 GATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWlsglansLLQSTLTVKLPFCGNNKVDNFLCEVPVMIKm 187
Cdd:cd15306  85 STASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVW-------LISIGIAIPVPIKGIETDVDNPNNITCVLT- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 188 scANTAFNIAMLSIVGTFYslVPLSLILVSYgFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSSSS 267
Cdd:cd15306 157 --KERFGDFILFGSLAAFF--TPLAIMIVTY-FLTIHALRKQTITNEQRASKVLGIVFFLFLLMWCPFFITNITSVLCDS 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 47576593 268 QDKN---KLLSLF--YSLVTPMLNPFIYTLRNKDVKGAMRRFL 305
Cdd:cd15306 232 CNQTtlqMLMEIFvwIGYVSSGVNPLVYTLFNKTFRDAFGRYI 274
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
29-227 7.14e-06

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 46.82  E-value: 7.14e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  29 IMVLVAYVCT----VVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIP-QLLRNLWGPD-------KSISYRG 96
Cdd:cd14993   1 IVLIVLYVVVfllaLVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPlTLLENVYRPWvfgevlcKAVPYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  97 CVTQfyifhflgATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLAnsllqstltVKLPFCGNNKVDN 176
Cdd:cd14993  81 GVSV--------SASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAII---------IMLPLLVVYELEE 143
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 177 FLCEVPVMIKMSC---------ANTAFNIAMLsivgTFYSLVPLSLILVSYGFIVATVLR 227
Cdd:cd14993 144 IISSEPGTITIYIctedwpspeLRKAYNVALF----VVLYVLPLLIISVAYSLIGRRLWR 199
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
31-225 1.13e-05

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 46.25  E-value: 1.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  31 VLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCvtQFYIF--HFLG 108
Cdd:cd15336   7 ILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGC--ELYAFcgALFG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 109 ATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLlqstltvkLPFCGnnkvdnFLCEVPVMIKMS 188
Cdd:cd15336  85 ITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSL--------PPLFG------WSAYVPEGLLTS 150
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 47576593 189 CA-----NTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATV 225
Cdd:cd15336 151 CTwdymtFTPSVRAYTMLLFCFVFFIPLGIIIYCYLFIFLAI 192
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
115-300 1.33e-05

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 45.78  E-value: 1.33e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 115 LAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLlqstltvkLPFCG---NNKVDNFLCevpvMIKMSCAN 191
Cdd:cd15064  91 LCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISL--------PPLFGwrtPDSEDPSEC----LISQDIGY 158
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 192 TAFniamlSIVGTFYslVPLSLILVSYGFIVATVLRIRssegkkKAFNTCGSHVVVVTLFYGP--VISMyVQPSSSSSQD 269
Cdd:cd15064 159 TIF-----STFGAFY--IPLLLMLILYWKIYRAAARER------KAAKTLGIILGAFIVCWLPffLVAL-IVPLCSHCWI 224
                       170       180       190
                ....*....|....*....|....*....|...
gi 47576593 270 KNKLLSLFYSL--VTPMLNPFIYTLRNKDVKGA 300
Cdd:cd15064 225 PLALKSFFLWLgyFNSLINPLIYTFFNKDFRKA 257
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
27-296 1.35e-05

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 45.81  E-value: 1.35e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIP-QLLRNLWGpdkSISYRGCVTQFYI-F 104
Cdd:cd15061   2 LISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPlAIIRQLLG---YWPLGSHLCDFWIsL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 105 HFLGATECIL-LAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLlqstltvkLPFCGNNKvdnflcEVPV 183
Cdd:cd15061  79 DVLLCTASILnLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITS--------PPLVGPSW------HGRR 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 184 MIKMSCANTAFNIAMLSIVGTFYslVPLSLILvsygFIVATVLRIRSSEgkKKAFNTCGSHVVVVTLFYGPVISMYVQPS 263
Cdd:cd15061 145 GLGSCYYTYDKGYRIYSSMGSFF--LPLLLML----FVYLRIFRVIAKE--RKTAKTLAIVVGCFIVCWLPFFIMYLIEP 216
                       250       260       270
                ....*....|....*....|....*....|....*
gi 47576593 264 SSSSQDKNKLLSLFYSL--VTPMLNPFIYTLRNKD 296
Cdd:cd15061 217 FCDCQFSEALSTAFTWLgyFNSVINPFIYAFYNKD 251
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
22-295 1.40e-05

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 45.84  E-value: 1.40e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  22 WLEMPLFIMVlvaYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDL-----CFTTTTIPQLLRN-LWGPDKsisyr 95
Cdd:cd15206   1 ELIIPLYSVI---FLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLllavfCMPFTLVGQLLRNfIFGEVM----- 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  96 gCVTQFYIFHFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGlansllqstLTVKLPFCGNNKVD 175
Cdd:cd15206  73 -CKLIPYFQAVSVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLS---------FLIMSPILVFSNLI 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 176 NFLCEVPVMIKMSCANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLrirssEGKKKA----------FNTCGSHV 245
Cdd:cd15206 143 PMSRPGGHKCREVWPNEIAEQAWYVFLDLMLLVIPGLVMSVAYGLISWTLL-----EAKKRVirmlfvivveFFICWTPL 217
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 47576593 246 VVVT---LFYGPVISMYVQPSSSSsqdknklLSLFYSLVTPMLNPFIYTLRNK 295
Cdd:cd15206 218 YVINtwkAFDPPSAARYVSSTTIS-------LIQLLAYISSCVNPITYCFMNK 263
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
29-130 1.49e-05

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 45.92  E-value: 1.49e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  29 IMVLVAYVCT--VVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDL-CFTTTTIPQLLRNLWGpDKSISYRGCVTQFYIFH 105
Cdd:cd15075   3 LSIIMAVFSIasVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLgTTVFGGLLSVVTNAVG-YFNLGRVGCVLEGFAVA 81
                        90       100
                ....*....|....*....|....*
gi 47576593 106 FLGATECILLAVMSLDRYIAICKPL 130
Cdd:cd15075  82 FFGIAALCTVAVIAVDRLFVVCKPL 106
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
27-157 1.54e-05

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 45.67  E-value: 1.54e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAyvctVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQllrnlwgpDKSISYRGCVTQFYIF-- 104
Cdd:cd15327   7 LAIFILMA----IVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPF--------SATLEVLGFWAFGRVFcd 74
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 47576593 105 -----HFLGATECIL-LAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSL 157
Cdd:cd15327  75 iwaavDVLCCTASILsLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISI 133
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
33-301 2.19e-05

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 45.11  E-value: 2.19e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  33 VAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIP----QLLRNLWgpdkSISYRGCvtQFYIFH--F 106
Cdd:cd15073   9 VAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPfsaaSDLHGSW----KFGYAGC--QWYAFLniF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMfMTWLSGLANSLlqstltvkLPFCGNNKVDNFLCEVPVMIK 186
Cdd:cd15073  83 FGMASIGLLTVVAVDRYLTICRPDLGRKMTTNTYTVMIL-LAWTNAFFWAA--------MPLVGWASYALDPTGATCTIN 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 187 MSCANTAF-NIAMLSIVGTFysLVPLSLILVSYgFIVATVLRIRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYV---QP 262
Cdd:cd15073 154 WRKNDSSFvSYTMSVIVVNF--IVPLAVMFYCY-YNVSRFVKKVLASDCLESVNIDWTDQNDVTKMSVIMIVMFLvawSP 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 47576593 263 SS-----SSSQDKNKlLSLFYSLVTPML-------NPFIYTLRNKDVKGAM 301
Cdd:cd15073 231 YSivclwASFGEPKK-IPPWMAIIPPLFaksstfyNPCIYVIANKKFRRAI 280
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
26-232 3.00e-05

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 45.01  E-value: 3.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  26 PLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWgpdksisyrgcvtQFYIFH 105
Cdd:cd15134   2 PITIIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIW-------------QQYPWV 68
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 106 FlGATECILLAVM---------------SLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLT-----VK 165
Cdd:cd15134  69 F-GEVFCKLRAFLsemssyasvltitafSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPFAIQTrivylEY 147
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47576593 166 LPFCGNNKVDNFLCEVPvmikmscaNTAFNIAMLSIVGTF-YSLVPLSLILVSYGFIvatVLRIRSSE 232
Cdd:cd15134 148 PPTSGEALEESAFCAML--------NEIPPITPVFQLSTFlFFIIPMIAIIVLYVLI---GLQLRRST 204
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
29-131 3.47e-05

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 44.81  E-value: 3.47e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  29 IMVL-VAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTT-TTIPQLLRNL----WGPDKSISyrgCVTQFY 102
Cdd:cd15385   4 IAVLaVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFfQVLPQLCWDItyrfYGPDFLCR---IVKHLQ 80
                        90       100
                ....*....|....*....|....*....
gi 47576593 103 IFHFLGATecILLAVMSLDRYIAICKPLR 131
Cdd:cd15385  81 VLGMFAST--YMLVMMTADRYIAICHPLK 107
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
29-300 3.63e-05

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 44.54  E-value: 3.63e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  29 IMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIP-QLLRNLWGPDKSISYRGCVTQFYIFHFL 107
Cdd:cd15304   5 LLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPvSMLTILYGYRWPLPSKLCAVWIYLDVLF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 108 GATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLAnsllqstLTVKLPFCGNNKvdnflcEVPVMIKM 187
Cdd:cd15304  85 STASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVG-------ISMPIPVFGLQD------DSKVFKEG 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 188 SCANTAFNIAMLSIVGTFYslVPLSLILVSYGFIVATVLRIRSSEgkKKAFNTCGS----HVVVVTLFYGPVISMYVQPS 263
Cdd:cd15304 152 SCLLADENFVLIGSFVAFF--IPLTIMVITYFLTIKSLQQSISNE--QKASKVLGIvfflFVVMWCPFFITNVMAVICKE 227
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47576593 264 SSSSQDKNKLLSLFY--SLVTPMLNPFIYTLRNKDVKGA 300
Cdd:cd15304 228 SCNEVVIGGLLNVFVwiGYLSSAVNPLVYTLFNKTYRSA 266
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
26-131 3.84e-05

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 44.57  E-value: 3.84e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  26 PLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFH 105
Cdd:cd15001   1 PVIIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQL 80
                        90       100
                ....*....|....*....|....*.
gi 47576593 106 FLGATECILLAVMSLDRYIAICKPLR 131
Cdd:cd15001  81 LSFICSVLTLTAISIERYYVILHPMK 106
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
27-296 5.25e-05

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 43.80  E-value: 5.25e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIP----QLLRNLWgpdksiSYRGCVTQFY 102
Cdd:cd15329   3 IGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPlaiiYELSGYW------PFGEILCDVW 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 103 I-FHFLGATECIL-LAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLlqstltvkLPFCG--NNKVDNFL 178
Cdd:cd15329  77 IsFDVLLCTASILnLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISI--------PPLFGwkNKVNDPGV 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 179 CEVpvmikmsCANTAFNIamLSIVGTFYslVPLSLILVSYGFIvatvLRIRSSEGkkKAFNTCGSHVVVVTL-------- 250
Cdd:cd15329 149 CQV-------SQDFGYQI--YATFGAFY--IPLIVMLVLYYKI----YRAAKSER--KAIKTLGIIMGAFTLcwlpffil 211
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 47576593 251 -----FYGPVISMYVQPSSSSsqdknklLSLFYSLVTPMLNPFIYTLRNKD 296
Cdd:cd15329 212 allrpFLKPIKCSCIPLWLSR-------LFLWLGYANSFLNPIIYAKFNRE 255
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
62-159 6.06e-05

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 43.99  E-value: 6.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  62 FLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFC 141
Cdd:cd15219  38 FLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLETFLTSNAMLSMAALSIDRWIAVVFPLSYTSKMRYRDA 117
                        90
                ....*....|....*...
gi 47576593 142 ILLMFMTWLSGLANSLLQ 159
Cdd:cd15219 118 ALMVGYSWLHSLTFSLVA 135
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
27-300 6.17e-05

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 43.57  E-value: 6.17e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVC-TVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIP----QLLRNLWgpdksiSYRGCVTQF 101
Cdd:cd15060   2 VTTILLSVIIAfTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPlnvaYFLLGKW------LFGIHLCQM 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 102 YI-FHFLGATECIL-LAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLsglanslLQSTLTVKLPFCGNNKVDNFlc 179
Cdd:cd15060  76 WLtCDILCCTASILnLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWA-------LSALISVPPLIGWNDWPENF-- 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 180 evpvMIKMSCANTAFN-IAMLSIVGTFYslVPLSLILVSYGFIvatvlrIRSSEGKKKAFNTCGSHVVVVTLFYGPVISM 258
Cdd:cd15060 147 ----TETTPCTLTEEKgYVIYSSSGSFF--IPLLIMTIVYVKI------FIATSKERRAARTLGIIMGVFVVCWLPFFLM 214
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 47576593 259 YV-QPSSSSSQDKNKLLSLFYSL--VTPMLNPFIYTLRNKDVKGA 300
Cdd:cd15060 215 YViLPFCETCSPSAKVVNFITWLgyVNSALNPVIYTIFNLDFRRA 259
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
29-239 7.46e-05

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 43.78  E-value: 7.46e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  29 IMVLVAYVCTVVGNI-SIIVVSKidPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRG-----CVTQFY 102
Cdd:cd14978   5 YVLPVICIFGIIGNIlNLVVLTR--KSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYfyayfLPYIYP 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 103 IFHFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNNKVDNFLCEVP 182
Cdd:cd14978  83 LANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPT 162
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 47576593 183 VMIKMSCANTAFNIAMLSIVGTFyslVPLSLILVSYGFIVATVLRIRSSEGKKKAFN 239
Cdd:cd14978 163 LLRQNETYLLKYYFWLYAIFVVL---LPFILLLILNILLIRALRKSKKRRRLLRRRR 216
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
25-254 7.49e-05

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 43.79  E-value: 7.49e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  25 MPLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTT---TIPQLLRNLWGPDKSISYRGCVTQF 101
Cdd:cd14982   1 TLFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTlpfRIYYYLNGGWWPFGDFLCRLTGLLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 102 YIFHFLGateCILLAVMSLDRYIAICKPLRYPAIMHQQF----CILLMFMTWLSGLANSLLQSTLTVKlpfCGNNKVDNF 177
Cdd:cd14982  81 YINMYGS---ILFLTCISVDRYLAVVHPLKSRRLRRKRYavgvCAGVWILVLVASVPLLLLRSTIAKE---NNSTTCFEF 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 178 LcevpvMIKMSCANTAFNIAMlsivgTFYSLVPLSLILVSYGFIVATVLRIRSSEG----KKKAFNTCGSHVVVVTLFYG 253
Cdd:cd14982 155 L-----SEWLASAAPIVLIAL-----VVGFLIPLLIILVCYSLIIRALRRRSKQSQksvrKRKALRMILIVLAVFLVCFL 224

                .
gi 47576593 254 P 254
Cdd:cd14982 225 P 225
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
28-298 9.14e-05

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 43.39  E-value: 9.14e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  28 FIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHFL 107
Cdd:cd15214   3 SIAIIIIAILICLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLI 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 108 GATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLqstltvklPFCGNNKV--DNFLCEVPVMI 185
Cdd:cd15214  83 SSASMLTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIWLHSLIGCLP--------PLFGWSSLefDRFKWMCVAAW 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 186 KMSCANTAFNIamlsivgTFYSLVPLSLILVSYGFIvatvlrIRSSEGKK-KAFNTCGSHVVVVTLFYGP---VISMYVQ 261
Cdd:cd15214 155 HKEAGYTAFWQ-------VWCALLPFVVMLVCYGFI------FRVARANQcKAFITILVVLGAFVTTWGPymvVISTEAL 221
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47576593 262 PSSSSSQDKNKLLSLFYSLVTPMLNPFIYTLRNKDVK 298
Cdd:cd15214 222 WGKNSVSPQLETLATWLSFTSAVCHPLIYGLWNKTVR 258
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
35-300 9.27e-05

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 43.04  E-value: 9.27e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  35 YVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIP-----QLLrNLWGPDKSIsyrgcVTQFYIFHFLGA 109
Cdd:cd15330  11 ILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPmaalyQVL-NKWTLGQVT-----CDLFIALDVLCC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 110 TECIL-LAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSlLQSTLTVKLPfcgNNKVDNFLCEVpvmikms 188
Cdd:cd15330  85 TSSILhLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSIS-IPPMLGWRTP---EDRSDPDACTI------- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 189 caNTAFNIAMLSIVGTFYslVPLSLILVSYGFIvatvlrIRSSEGKKKAFNTCGSHVVVVTLFYGP-VISMYVQPSSSSS 267
Cdd:cd15330 154 --SKDPGYTIYSTFGAFY--IPLILMLVLYGRI------FKAAARERKTVKTLGIIMGTFILCWLPfFIVALVLPFCEST 223
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47576593 268 QDKNKLLS-----LFYSlvTPMLNPFIYTLRNKDVKGA 300
Cdd:cd15330 224 CHMPELLGaiinwLGYS--NSLLNPIIYAYFNKDFQSA 259
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
36-221 1.02e-04

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 43.19  E-value: 1.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  36 VCTVVGNISIIVVSKIDPQLDSPMY-FFLSNLSFLDLCFTTTTIP----QLLRNLWGpdksisyRGCVTQFYI-FHFLGA 109
Cdd:cd15057  12 LLTLLGNALVIAAVLRFRHLRSKVTnYFIVSLAVSDLLVAILVMPwaavNEVAGYWP-------FGSFCDVWVsFDIMCS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 110 TECIL-LAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWlsglANSLLQSTLTVKLPF--CGNNKVDNFLCEVPVMIK 186
Cdd:cd15057  85 TASILnLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAW----TLSALISFIPVQLGWhrADDTSEALALYADPCQCD 160
                       170       180       190
                ....*....|....*....|....*....|....*
gi 47576593 187 MScANTAFniAMLSIVGTFYslVPLSLILVSYGFI 221
Cdd:cd15057 161 SS-LNRTY--AISSSLISFY--IPVAIMIVTYTRI 190
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
29-132 1.37e-04

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 42.61  E-value: 1.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  29 IMVL-VAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTI-PQLLrnlWgpDKSISYRG----C--VTQ 100
Cdd:cd15196   4 IAVLaTILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALFNVlPQLI---W--DITYRFYGgdllCrlVKY 78
                        90       100       110
                ....*....|....*....|....*....|..
gi 47576593 101 FYIFHFLGATecILLAVMSLDRYIAICKPLRY 132
Cdd:cd15196  79 LQVVGMYASS--YVLVATAIDRYIAICHPLSS 108
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
115-300 1.57e-04

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 42.48  E-value: 1.57e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 115 LAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSglansllqSTLTVKLPFCGNNKVDNFLCEVPVMIKMSCANTAF 194
Cdd:cd15063  91 LCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVL--------SFVICFPPLVGWNDGKDGIMDYSGSSSLPCTCELT 162
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 195 N---IAMLSIVGTFYslVPLSLILVSYGFIVatvlriRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSSSSQDKN 271
Cdd:cd15063 163 NgrgYVIYSALGSFY--IPMLVMLFFYFRIY------RAARMETKAAKTVAIIVGCFIFCWLPFFTVYLVRAFCEDCIPP 234
                       170       180       190
                ....*....|....*....|....*....|.
gi 47576593 272 KLLSLFYSL--VTPMLNPFIYTLRNKDVKGA 300
Cdd:cd15063 235 LLFSVFFWLgyCNSALNPCIYALFSRDFRFA 265
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
21-234 1.79e-04

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 42.44  E-value: 1.79e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  21 PWLEMPLFIMVLVayvcTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIP----QLLRNLWGpdksisyrg 96
Cdd:cd15058   1 PGLLLLLALIILA----IVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPlgatIVVTGKWQ--------- 67
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  97 cvtqfyifhfLGATECIL---------------LAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSglanSLLQST 161
Cdd:cd15058  68 ----------LGNFWCELwtsvdvlcvtasietLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIV----SALVSF 133
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 162 LTVKLPFCGNNKVDNFLCEVPvmiKMSCA---NTAFniAMLSIVGTFYslVPLSLILVSYG--FIVAT--VLRIRSSEGK 234
Cdd:cd15058 134 VPIMNQWWRANDPEANDCYQD---PTCCDfrtNMAY--AIASSVVSFY--IPLLIMIFVYArvFLIATrqLQLIDKRRLR 206
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-132 2.62e-04

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 42.03  E-value: 2.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  28 FIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCftTTTIPQLLRNLWgpDKSISYR----GCVTQFYI 103
Cdd:cd15197   4 LATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLC--VGLINVLTDIIW--RITVEWRagdfACKVIRYL 79
                        90       100
                ....*....|....*....|....*....
gi 47576593 104 FHFLGATECILLAVMSLDRYIAICKPLRY 132
Cdd:cd15197  80 QVVVTYASTYVLVALSIDRYDAICHPMNF 108
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
115-292 2.71e-04

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 41.77  E-value: 2.71e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 115 LAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWL-SGLANSLLqstLTVKLPFCGNNKVDNFLCEVPVMIKmscanta 193
Cdd:cd15055  91 LVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFvSALYSSVL---LYDNLNQPGLIRYNSCYGECVVVVN------- 160
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 194 FNIAMLSIVGTFYslVPLSLILVSYG--FIVAT--VLRIRS------SEGKK---------KAFNTCGSHVVVVTLFYGP 254
Cdd:cd15055 161 FIWGVVDLVLTFI--LPCTVMIVLYMriFVVARsqARAIRShtaqvsLEGSSkkvskkserKAAKTLGIVVGVFLLCWLP 238
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 47576593 255 --VISMYVQPSSSSSQDKNKLLSLFYslVTPMLNPFIYTL 292
Cdd:cd15055 239 yyIVSLVDPYISTPSSVFDVLIWLGY--FNSCLNPLIYAL 276
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
29-301 3.51e-04

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 41.51  E-value: 3.51e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  29 IMVLVAYVCT--VVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHF 106
Cdd:cd14972   1 VLVVAIVLGVfiVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGATECILLAVmSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLlqstltvkLPFCGNNKVDnflCEVPvmik 186
Cdd:cd14972  81 LLASAYSLLAI-AVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLAL--------LPVLGWNCVL---CDQE---- 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 187 mSCANTAFNIAM-LSIVGTFYSLVPLSLILVSYGFIVATVLR--------------IRSSEGKKKAFNtcgshVVVVT-- 249
Cdd:cd14972 145 -SCSPLGPGLPKsYLVLILVFFFIALVIIVFLYVRIFWCLWRhanaiaarqeaavpAQPSTSRKLAKT-----VVIVLgv 218
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 47576593 250 --LFYGPVISMYVQPSSSSSQ---DKNKLLSLFYSLVTPMLNPFIYTLRNKDVKGAM 301
Cdd:cd14972 219 flVCWLPLLILLVLDVLCPSVcdiQAVFYYFLVLALLNSAINPIIYAFRLKEMRRAV 275
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
29-153 3.90e-04

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 41.35  E-value: 3.90e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  29 IMVLVAYV---CTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFH 105
Cdd:cd15301   2 LIVIVAAVlslVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDY 81
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 47576593 106 FLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGL 153
Cdd:cd15301  82 LASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISL 129
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
29-159 4.44e-04

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 41.32  E-value: 4.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  29 IMVLVA-YVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTT-TTIPQLLRNL----WGPD---KSISYRGCVT 99
Cdd:cd15386   4 IGVLAAiLVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALfQVLPQLIWEItyrfQGPDllcRAVKYLQVLS 83
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 100 QFyifhflgATECILLAvMSLDRYIAICKPLRYPAIMHQQFCILLMfMTWLSGLANSLLQ 159
Cdd:cd15386  84 MF-------ASTYMLIM-MTVDRYIAVCHPLRTLQQPSRQAYLMIG-ATWLLSCILSLPQ 134
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
25-157 6.41e-04

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 40.80  E-value: 6.41e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  25 MPLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIP-QLLRNLWGPDKSISYRGCVTQFYI 103
Cdd:cd14979   1 VLVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPvELYNFWWQYPWAFGDGGCKLYYFL 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 47576593 104 FHFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSL 157
Cdd:cd14979  81 FEACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAI 134
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
29-157 6.91e-04

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 40.81  E-value: 6.91e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  29 IMVLVAY----VCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDL-----CFTTTTIPQLLRNLW--GPD--KSISYR 95
Cdd:cd15392   1 VIIILMYstifVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDIlmavfCVPFSFIALLILQYWpfGEFmcPVVNYL 80
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47576593  96 GCVTQFyifhflgaTECILLAVMSLDRYIAICKPLRYPaiMHQQFCILLMFMTWLSGLANSL 157
Cdd:cd15392  81 QAVSVF--------VSAFTLVAISIDRYVAIMWPLRPR--MTKRQALLLIAVIWIFALATAL 132
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
27-150 7.05e-04

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 40.51  E-value: 7.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLS----FLDLCFTTTTIPQLLRNLWGPDKSIsyrgCVTQFY 102
Cdd:cd15317   3 IYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLAtadfLLGLCVMPFSMIRTVETCWYFGDLF----CKFHTG 78
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 47576593 103 IFHFLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWL 150
Cdd:cd15317  79 LDLLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWL 126
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
26-157 7.42e-04

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 40.67  E-value: 7.42e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  26 PLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIP-QLLRNLwgpdksisyrgcvTQFYIF 104
Cdd:cd15203   2 ILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPfTLIYTL-------------TKNWPF 68
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 47576593 105 -----HFLGATECI-------LLAVMSLDRYIAICKPLRYPaiMHQQFCILLMFMTWLSGLANSL 157
Cdd:cd15203  69 gsilcKLVPSLQGVsifvstlTLTAIAIDRYQLIVYPTRPR--MSKRHALLIIALIWILSLLLSL 131
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
25-182 1.07e-03

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 39.98  E-value: 1.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  25 MPLFIMVLVayVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIP----QLLRNLWGpdksISYRGCVTq 100
Cdd:cd15048   3 LAVLISVLI--LVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPfyipYTLTGKWP----FGKVFCKA- 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 101 FYIFHFLGATECILLAVM-SLDRYIAICKPLRYPAIMHQQFCILLMFMTWLsgLANSLLQSTLTVKLPFCGNNKVDNFLC 179
Cdd:cd15048  76 WLVVDYTLCTASALTIVLiSLDRYLSVTKAVKYRAKQTKRRTVLLMALVWI--LAFLLYGPAIIGWDLWTGYSIVPTGDC 153

                ...
gi 47576593 180 EVP 182
Cdd:cd15048 154 EVE 156
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
26-229 1.24e-03

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 39.78  E-value: 1.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  26 PLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLcFTTTTIPQLLRNLWGPdKSISYRGCVTQFYIFH 105
Cdd:cd15928   2 AVTAVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDL-LIFLVLPLDLYRLWRY-RPWRFGDLLCRLMYFF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 106 FLGATECILLAV--MSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANS----LLQSTLTVklpfcgNNKVDNFLC 179
Cdd:cd15928  80 SETCTYASILHItaLSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAgpalVLVGVEHI------QGQQTPRGF 153
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 47576593 180 EvpvmikmsCANTAFNIAMLSI---VGTFYSLVPLSLILVSYGFIVATVLRIR 229
Cdd:cd15928 154 E--------CTVVNVSSGLLSVmlwVSTSFFFVPMVCLSLLYGLIGRALWDRR 198
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
39-157 2.09e-03

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 39.17  E-value: 2.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  39 VVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHFLGATECILLAVM 118
Cdd:cd15210  15 VPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLVAVSLLTLVLI 94
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 47576593 119 SLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSL 157
Cdd:cd15210  95 TLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFL 133
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
25-221 2.18e-03

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 39.01  E-value: 2.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  25 MPLFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLcFTTTTIPQLLRNLWGPDKSIsYRGCVTQFYIF 104
Cdd:cd15132   1 IPVTIVCLILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDL-LILLCLPFDLYRLWKSRPWI-FGEFLCRLYHY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 105 HFLGATECILLAV--MSLDRYIAICKPLRYPAIMHQQFCILLMFMTWlsglANSLLQSTltvklPFCGNNKVDNFLCEVP 182
Cdd:cd15132  79 ISEGCTYATILHItaLSIERYLAICFPLRAKVLVTRRRVKCVIAALW----AFALLSAG-----PFLFLVGVEQDNNIHP 149
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 47576593 183 VMIKMSCANT--AFNIAMLSI---VGTFYSLVPLSLILVSYGFI 221
Cdd:cd15132 150 DDFSRECKHTpyAVSSGLLGImiwVTTTYFFLPMLCLSFLYGFI 193
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
39-225 2.30e-03

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 39.23  E-value: 2.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  39 VVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTT------TIpQLLRNLWGPDKSisyrGCvtQFY-----IFHFL 107
Cdd:cd15337  15 VIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVngfplkTI-SSFNKKWIWGKV----AC--ELYgfaggIFGFM 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 108 GATEcilLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLsglaNSLLQSTltvkLPFCGnnkvdnFLCEVPVMIKM 187
Cdd:cd15337  88 SITT---LAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWL----WSLLWSI----PPFFG------WGRYVPEGFQT 150
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 47576593 188 SCA-----NTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATV 225
Cdd:cd15337 151 SCTfdylsRDLNNRLFILGLFIFGFLCPLLIIIFCYVNIIRAV 193
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
22-157 2.36e-03

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 39.02  E-value: 2.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  22 WLEMPLFIMVLVayvcTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIP-QLLRNLWGpdKSISYRGCVTQ 100
Cdd:cd15054   2 WVAAFLCLIILL----TVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPpAMLNALYG--RWVLARDFCPI 75
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 47576593 101 FYIFHFLGATECIL-LAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTW-LSGLANSL 157
Cdd:cd15054  76 WYAFDVMCCSASILnLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWtLAALASFL 134
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
29-298 3.43e-03

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 38.41  E-value: 3.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  29 IMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHFLG 108
Cdd:cd17790   5 ITTGILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYVAS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 109 ATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLsgLANSLLQSTLTVKLPFCGNNKVDNFLCEVPVmikMS 188
Cdd:cd17790  85 NASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWL--ISFVLWAPAILFWQYLVGERTVLAGQCYIQF---LS 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 189 CANTAFNIAMlsivGTFYslVPLSLILVSYGFIVatvlriRSSEGKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSSSSQ 268
Cdd:cd17790 160 QPIITFGTAI----AAFY--LPVTIMIILYWRIY------RETIKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDC 227
                       250       260       270
                ....*....|....*....|....*....|..
gi 47576593 269 DKNKLLSLFYSL--VTPMLNPFIYTLRNKDVK 298
Cdd:cd17790 228 VPKTLWELGYWLcyVNSTVNPMCYALCNKSFR 259
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
27-225 3.47e-03

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 38.33  E-value: 3.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTiPQLLRNLWGPDKSISYRGCvtqfYIFHF 106
Cdd:cd15079   3 LGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKM-PIFIYNSFYEGWALGPLGC----QIYAF 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 107 LGA----TECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFmTWLSGLANSLlqstltvkLPFCGnnKVDNFlceVP 182
Cdd:cd15079  78 LGSlsgiGSIWTNAAIAYDRYNVIVKPLNGNPLTRGKALLLILF-IWLYALPWAL--------LPLLF--GWGRY---VP 143
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 47576593 183 VMIKMSC-----ANTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATV 225
Cdd:cd15079 144 EGFLTSCsfdylTRDWNTRSFVATIFVFAYVIPLIIIIYCYSFIVKAV 191
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
39-297 3.72e-03

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 38.64  E-value: 3.72e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  39 VVGN-ISIIVVSKI-DPQLDSPMYFFLSNLSFLDL---CFTT-TTIPQLLRNLWGPDKSIsyrgCVTQFYIFHFLGATEC 112
Cdd:cd15142  15 VVGNlIAIVVLCKSrKEQKETTFYTLVCGLAVTDLlgtCLASpVTIATYLKGRWPGGQPL----CEYFSFILLFFSLSGL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 113 ILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQST--LTVKLPFCGNNKVDNFLCEVPVMIKMSCA 190
Cdd:cd15142  91 SIICAMSIERYLAINHAYFYNHYVDKRLAGLTLFAIYASNILFCALPSMglGKSKLQYPKTWCFIDWRTNVSVHAAYSYM 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 191 NTAFNIAMLSIVGTFYSLVPLSLILVSYGFIVATVLRIR---SSEGKKKAFNTC------------GSHVVVVTLFYGPV 255
Cdd:cd15142 171 YAGFSSLLILVTVLCNVLVCGALIRMHRQFVRRTSLGTDqrlSDFRRRRSFRRMagaeiqmvilliATSVVVLICSIPLV 250
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 47576593 256 ISMYV----QPSSSSSQDKN-KLLSLFYSLVTPMLNPFIYTLRNKDV 297
Cdd:cd15142 251 VRVFVnqlyQPAVEKDLDKNpDLQAIRIASVNPILDPWIYILLRKTV 297
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
42-290 3.95e-03

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 38.22  E-value: 3.95e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  42 NISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTtIPQLLRNLWGPDK-SISYRGCVTQFYIFHFLGATECILLAVMSL 120
Cdd:cd15365  18 NCISLYVSCLQIRKKNELGVYLFNLSLSDLLYIVI-LPLWIDYLWNGDNwTLSGFVCIFSAFLLYTNFYTSTALLTCIAL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 121 DRYIAICKPLRYPAIMHQQFCILLMFMTWL-SGLANSLlqsTLTVKLPFcgNNKVDNFLCEVPVMIKMSCANtaFNIAML 199
Cdd:cd15365  97 DRYLAVVHPLKFMHLRTIRTALSVSVAIWLlEICFNAV---ILTWEDSF--HESSSHTLCYDKFPLEDWQAR--LNLFRI 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 200 SIvgtfYSLVPLSLILVSYGFIVATVLRIRSSEG--KKKAFNTCGSHVVVVTLFYGPVISMYVQPSSSSSQDKNKLLSLF 277
Cdd:cd15365 170 CL----GYLLPLLIILFCYWKIYQAVRSNQATEDqeKKKIFKLLLLITVTFVICFTPYHVVLLIRSIVEPCDCRNAKWLY 245
                       250       260
                ....*....|....*....|.
gi 47576593 278 Y--------SLVTPMLNPFIY 290
Cdd:cd15365 246 TlykitvalTSLNCIADPFLY 266
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
29-157 4.23e-03

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 38.21  E-value: 4.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  29 IMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSI-SYRGCVTQFYIFHFL 107
Cdd:cd15212   5 LVLLAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRPGWLfGDRLCLANGFFNACF 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 47576593 108 GATECILLAVMSLDRYIAICKPLRypAIMHQQFCILLMFMTWLSGLANSL 157
Cdd:cd15212  85 GIVSTLTMTLISFDRYYAIVRQPQ--GKIGRRRALQLLAAAWLTALGFSL 132
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
27-158 4.93e-03

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 37.96  E-value: 4.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVayvcTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPqllrnlwgPDKSISYRGcvtqfyifHF 106
Cdd:cd15959   7 LSLAILV----IVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVP--------PGATILLTG--------HW 66
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47576593 107 -LGATECIL---------------LAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLL 158
Cdd:cd15959  67 pLGTTVCELwtsvdvlcvtasietLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFL 134
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
36-134 5.01e-03

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 37.92  E-value: 5.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  36 VCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIP-QLLRNLwgpdKSISYRG---CVTQFYIFHFLGATE 111
Cdd:cd15318  12 LIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPfSTIRSV----ESCWYFGdsfCRLHTCLDTLFCLTS 87
                        90       100
                ....*....|....*....|...
gi 47576593 112 CILLAVMSLDRYIAICKPLRYPA 134
Cdd:cd15318  88 IFHLCFISIDRHCAICDPLLYPS 110
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
38-306 5.37e-03

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 38.01  E-value: 5.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  38 TVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHFLGATECILLAV 117
Cdd:cd15299  17 TIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 118 MSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLAnsLLQSTLTVKLPFCGNNKVDNFLCEVPVMikmscanTAFNIA 197
Cdd:cd15299  97 ISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFV--LWAPAILFWQYFVGKRTVPPDECFIQFL-------SEPIIT 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 198 MLSIVGTFYslVPLSLILVSYGFIVATVLRirssegKKKAFNTCGSHVVVVTLFYGPVISMYVQPSSSSSQDKNKLLSLF 277
Cdd:cd15299 168 FGTAIAAFY--LPVTIMTILYWRIYKETIK------EKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLG 239
                       250       260       270
                ....*....|....*....|....*....|.
gi 47576593 278 YSL--VTPMLNPFIYTLRNKDVKGAMRRFLV 306
Cdd:cd15299 240 YWLcyINSTVNPVCYALCNKTFRTTFKMLLL 270
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
36-151 5.97e-03

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 37.56  E-value: 5.97e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  36 VCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLL-------RNLWGPDKSISYRGCVTQFYIFHFLG 108
Cdd:cd15352  12 IVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETImiavlnsGYLVISDQFIQHMDNVFDSMICISLV 91
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 47576593 109 ATECILLAVmSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLS 151
Cdd:cd15352  92 ASICNLLAI-AVDRYVTIFYALRYHSIMTVRKALVLIAVIWVV 133
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
115-158 6.00e-03

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 37.74  E-value: 6.00e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 47576593 115 LAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLL 158
Cdd:cd15066  90 LCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISFL 133
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
29-130 6.30e-03

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 37.83  E-value: 6.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  29 IMVLVA-YVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTT-TTIPQLLRN----LWGPD---KSISYRGCVT 99
Cdd:cd15388   4 IAVLAIiFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFfQVLPQLVWDitdrFRGPDvlcRLVKYLQVVG 83
                        90       100       110
                ....*....|....*....|....*....|.
gi 47576593 100 QFyifhflGATECILlaVMSLDRYIAICKPL 130
Cdd:cd15388  84 MF------ASSYMIV--AMTFDRHQAICRPM 106
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
58-290 7.06e-03

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 37.42  E-value: 7.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  58 PMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGC--VTQFYIFHFLGATecILLAVMSLDRYIAICKPLRYPAI 135
Cdd:cd15372  33 PSTIFLINLAVADLLLILVLPFKISYHFLGNNWPFGEGLCrvVTAFFYGNMYCSV--LLLMCISLDRYLAVVHPFFARTL 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 136 MHQQFCILLMFMTWLSGLANSLlqsTLTVKLPFCGNNKVDNFLCEVPVMIKMSCANTAFNIAMLSIVGTfysLVPLSLIL 215
Cdd:cd15372 111 RSRRFALCMCTAIWLIAAALTL---PLTLQRQSYPLERLNITLCHDVLPLDEQDTYLFYYFACLAVLGF---LLPLVVIL 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 216 VSYGFIVATVLRIRSSEGkkKAFNTCGSHVVVVTLFYGPV-ISMYVQPSSSSSQDKNKL-----LSLFYSLVTPMLNPFI 289
Cdd:cd15372 185 FCYGSVLHTLLRSGQRYG--HAMKLTVLVLVSFVLCFTPSnLLLLLHYSDPTLDDGGNLyivymVSLAISTLNSCVDPFI 262

                .
gi 47576593 290 Y 290
Cdd:cd15372 263 Y 263
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
28-150 7.24e-03

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 37.52  E-value: 7.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  28 FIMVLVAyVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPDKSISYRGCVTQFYIFHFL 107
Cdd:cd15085   5 FLMFLNA-TFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVNYF 83
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 47576593 108 GATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMtWL 150
Cdd:cd15085  84 GIVSLWSLTLLAYERYNVVCKPMGGLKLSTKRGYQGLLFI-WL 125
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
27-133 7.85e-03

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 37.27  E-value: 7.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTV--VGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTtIPQLLRNLWGPDKSISYRGCVTQFYIF 104
Cdd:cd14970   1 IVIPAVYSVVCVVglTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLG-LPFLATSYLLGYWPFGEVMCKIVLSVD 79
                        90       100
                ....*....|....*....|....*....
gi 47576593 105 HFLGATECILLAVMSLDRYIAICKPLRYP 133
Cdd:cd14970  80 AYNMFTSIFCLTVMSVDRYLAVVHPVKSL 108
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
29-131 8.73e-03

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 37.36  E-value: 8.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  29 IMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDL-CFTTTTIPQLLRNLWGPDKSI-SYRGCVTQFYiFHF 106
Cdd:cd14995   5 FLVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLmVLVAAGLPNEIESLLGPDSWIyGYAGCLLITY-LQY 83
                        90       100
                ....*....|....*....|....*..
gi 47576593 107 LG--ATECILLAvMSLDRYIAICKPLR 131
Cdd:cd14995  84 LGinASSLSITA-FTIERYIAICHPMK 109
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
115-300 8.86e-03

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 37.31  E-value: 8.86e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 115 LAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWLSGLANSLLQSTLtvklpfcGNNKVDNFLCEVPVMIKMSCANTAF 194
Cdd:cd15051  91 LFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFLPIHL-------GWNTPDGRVQNGDTPNQCRFELNPP 163
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 195 NIAMLSIvGTFYslVPLSLILVSYG--FIVA--TVLRIR-----SSEGKKKAFNTCGSHVVVVTLF---------YGPVI 256
Cdd:cd15051 164 YVLLVAI-GTFY--LPLLIMCGVYLriFRIAreQAKRINaltpaSTANSSKSAATAREHKATVTLAavlgafiicWFPYF 240
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 47576593 257 SMY----VQPSSSSSQDKNKLLSLFYslVTPMLNPFIYTLRNKDVKGA 300
Cdd:cd15051 241 TYFtyrgLCGDNINETALSVVLWLGY--ANSALNPILYAFLNRDFRRA 286
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
27-150 9.68e-03

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 36.95  E-value: 9.68e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  27 LFIMVLVAYVCTVVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIP-QLLRNLwgpdKSISYRGCVtqFYIFH 105
Cdd:cd15312   3 MYLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPySMVRSV----ESCWYFGDL--FCKIH 76
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 47576593 106 -----FLGATECILLAVMSLDRYIAICKPLRYPAIMHQQFCILLMFMTWL 150
Cdd:cd15312  77 ssldmMLSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWS 126
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
26-218 9.78e-03

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 37.03  E-value: 9.78e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593  26 PLFIMVLVAYVCT-VVGNISIIVVSKIDPQLDSPMYFFLSNLSFLDLCFTTTTIPQLLRNLWGPdksisyRGCVTQFYIF 104
Cdd:cd15394   1 PLIIPLYSLVVLVgVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEP------RGWVFGRFMC 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47576593 105 H--FLGATECILLAVMSL-----DRYIAICKPLRYPaiMHQQFCILLMFMTWLSGLANSLLQSTLTVKLPFCGNnkvDNF 177
Cdd:cd15394  75 YfvFLMQPVTVYVSVFTLtaiavDRYYVTVYPLRRR--ISRRTCAYIVAAIWLLSCGLALPAAAHTYYVEFKGL---DFS 149
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 47576593 178 LCEvPVMIKMSCANTAFNIAMLSIVgtfySLVPLSLILVSY 218
Cdd:cd15394 150 ICE-EFWFGQEKQRLAYACSTLLIT----YVLPLLAISLSY 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH