NCBI Conserved Domain Search

Conserved domains on [gi|47577443|ref|NP_001000630|]

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olfactory receptor Olr691 [Rattus norvegicus]

Protein Classification

olfactory receptor family 4A protein( domain architecture ID 11610412)

olfactory receptor family 4A protein is an odorant receptor belonging to the G-protein coupled receptor 1 family

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

24-289

1.11e-143

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 405.44 E-value: 1.11e-143

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  24 LCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMH 103
Cdd:cd15939   2 ICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 104 FFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15939  82 FFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 184 TLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTIRAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATTY 263
Cdd:cd15939 162 KLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTF 241

                       250       260
                ....*....|....*....|....*.
gi 47577443 264 PEDKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15939 242 PIDKVVAVFYTIITPMLNPLIYTLRN 267

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

24-289

1.11e-143

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 405.44 E-value: 1.11e-143

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  24 LCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMH 103
Cdd:cd15939   2 ICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 104 FFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15939  82 FFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 184 TLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTIRAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATTY 263
Cdd:cd15939 162 KLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTF 241

                       250       260
                ....*....|....*....|....*.
gi 47577443 264 PEDKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15939 242 PIDKVVAVFYTIITPMLNPLIYTLRN 267

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

29-301

5.29e-39

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 138.79 E-value: 5.29e-39

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443    29 FLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGGI 108
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443   109 EILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTLACT 188
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443   189 NTSR---VGLLVVANTgmMGLVTFLVLMwSYSFILYTIRAYPA-ESRRKALSTCSSHVTVVILFFVPVLFIYI--RPATT 262
Cdd:pfam13853 161 DIKVnniYGLFVVTST--FGIDSLLIVL-SYGLILRTVLGIASrEGRLKALNTCGSHVCAVLAFYTPMIGLSMvhRFGHN 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 47577443   263 YPE--DKVFALFYTILAPMFNPLIYTLRNTEMKNALRKVWC 301
Cdd:pfam13853 238 VPPllQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRMLL 278

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

24-289

1.11e-143

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 405.44 E-value: 1.11e-143

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  24 LCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMH 103
Cdd:cd15939   2 ICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 104 FFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15939  82 FFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 184 TLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTIRAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATTY 263
Cdd:cd15939 162 KLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTF 241

                       250       260
                ....*....|....*....|....*.
gi 47577443 264 PEDKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15939 242 PIDKVVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

24-289

2.31e-112

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 326.08 E-value: 2.31e-112

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  24 LCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMH 103
Cdd:cd15226   2 FLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 104 FFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15226  82 FFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 184 TLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTIRAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATTY 263
Cdd:cd15226 162 KLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTF 241

                       250       260
                ....*....|....*....|....*.
gi 47577443 264 PEDKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15226 242 PVDKFLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

24-289

4.19e-108

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 315.58 E-value: 4.19e-108

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  24 LCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMH 103
Cdd:cd13954   2 LLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 104 FFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd13954  82 SLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 184 TLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTIRAYP-AESRRKALSTCSSHVTVVILFFVPVLFIYIRPATT 262
Cdd:cd13954 162 KLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPsAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSS 241

                       250       260
                ....*....|....*....|....*....
gi 47577443 263 YP--EDKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd13954 242 YSsdLDKVVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

24-296

5.19e-106

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 310.54 E-value: 5.19e-106

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  24 LCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMH 103
Cdd:cd15225   2 LLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 104 FFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15225  82 FLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 184 TLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTIRAYP-AESRRKALSTCSSHVTVVILFFVPVLFIYIRPATT 262
Cdd:cd15225 162 KLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPsAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577443 263 Y--PEDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15225 242 YspETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

26-289

2.21e-101

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 298.27 E-value: 2.21e-101

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  26 FPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFF 105
Cdd:cd15230   4 FVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 106 GGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15230  84 GTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 186 ACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATTYP 264
Cdd:cd15230 164 SCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITIlRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSSYS 243

                       250       260
                ....*....|....*....|....*..
gi 47577443 265 --EDKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15230 244 ldQDKVVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

9-299

3.93e-97

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 288.49 E-value: 3.93e-97

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443   9 EFILLGLSQNKKIKTLCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERN 88
Cdd:cd15943   1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  89 IISYTSCMLQLFTMHFFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCG 168
Cdd:cd15943  81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 169 HNEMDHYFCDIYPLLTLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVIL 247
Cdd:cd15943 161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAIlRIHSSEGRRKAFSTCASHLMAVTI 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 47577443 248 FFVPVLFIYIRPATTYPE--DKVFALFYTILAPMFNPLIYTLRNTEMKNALRKV 299
Cdd:cd15943 241 FYGTTLFMYLRPSSSYSLdqDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRI 294

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

26-289

5.87e-97

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 286.92 E-value: 5.87e-97

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  26 FPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFF 105
Cdd:cd15936   4 FLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFT 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 106 GGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15936  84 GGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 186 ACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTIRAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATTYPE 265
Cdd:cd15936 164 ACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQTFPM 243

                       250       260
                ....*....|....*....|....
gi 47577443 266 DKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15936 244 DKAVSVLYTVITPMLNPMIYTLRN 267

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

26-289

4.46e-96

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 284.72 E-value: 4.46e-96

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  26 FPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFF 105
Cdd:cd15940   4 FMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 106 GGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15940  84 ACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 186 ACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTIRAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATTYPE 265
Cdd:cd15940 164 ACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSFSE 243

                       250       260
                ....*....|....*....|....
gi 47577443 266 DKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15940 244 DKVVSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

23-289

8.92e-94

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 278.96 E-value: 8.92e-94

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  23 TLCFPLFLFCYISILGGNMFILISI-TYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFT 101
Cdd:cd15935   1 LLLFVLVLACYAAILLGNLLIVVTVhADPHLLQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 102 MHFFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYP 181
Cdd:cd15935  81 LHFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQ 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 182 LLTLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTIRAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPAT 261
Cdd:cd15935 161 VIKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFS 240

                       250       260
                ....*....|....*....|....*...
gi 47577443 262 TYPEDKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15935 241 SSSVDKVASVFYTLITPALNPLIYTLRN 268

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

26-289

1.08e-93

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 278.68 E-value: 1.08e-93

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  26 FPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFF 105
Cdd:cd15938   4 FALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFV 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 106 GGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15938  84 GAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 186 ACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTIRAypAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATTYPE 265
Cdd:cd15938 164 ACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTILVTIRS--TEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTFPV 241

                       250       260
                ....*....|....*....|....
gi 47577443 266 DKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15938 242 DKHVSVLYNVITPMLNPLIYTLRN 265

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

26-298

7.03e-92

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 274.52 E-value: 7.03e-92

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  26 FPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFF 105
Cdd:cd15417   4 FVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGM 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 106 GGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15417  84 GLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLLSL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 186 ACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATTY- 263
Cdd:cd15417 164 SCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTIlKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSSHs 243

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577443 264 -PEDKVFALFYTILAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15417 244 qDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

24-296

1.32e-91

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 273.76 E-value: 1.32e-91

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  24 LCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMH 103
Cdd:cd15231   2 LLFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 104 FFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15231  82 SFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 184 TLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATT 262
Cdd:cd15231 162 KLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTIlKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSG 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577443 263 YP--EDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15231 242 YSldKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

10-293

7.71e-91

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 272.27 E-value: 7.71e-91

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  10 FILLGLSQNKKIKTLCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNI 89
Cdd:cd15408   1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  90 ISYTSCMLQLFTMHFFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGH 169
Cdd:cd15408  81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 170 NEMDHYFCDIYPLLTLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILF 248
Cdd:cd15408 161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATIlRMRSAEGRHKAFSTCASHLTAVTLF 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 47577443 249 FVPVLFIYIRPATTYPE--DKVFALFYTILAPMFNPLIYTLRNTEMK 293
Cdd:cd15408 241 YGSLAFMYLRPSSRYSLdlDKVASVFYTVVIPMLNPLIYSLRNKEVK 287

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

24-296

3.05e-90

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 270.25 E-value: 3.05e-90

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  24 LCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMH 103
Cdd:cd15235   3 LLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFI 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 104 FFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15235  83 AFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 184 TLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTIRAYP-AESRRKALSTCSSHVTVVILFFVPVLFIYIRPATT 262
Cdd:cd15235 163 KLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPsAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSS 242

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577443 263 YP--EDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15235 243 YSadKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

26-296

3.94e-90

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 270.24 E-value: 3.94e-90

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  26 FPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFF 105
Cdd:cd15229   4 FLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 106 GGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15229  84 AGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 186 ACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATTY- 263
Cdd:cd15229 164 SCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTIlRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSASs 243

                       250       260       270
                ....*....|....*....|....*....|....
gi 47577443 264 -PEDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15229 244 sVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

23-289

1.15e-87

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 263.58 E-value: 1.15e-87

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  23 TLCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTM 102
Cdd:cd15911   1 ILLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 103 HFFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPL 182
Cdd:cd15911  81 GSLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 183 LTLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTIRAYPAES-RRKALSTCSSHVTVVILFFVPVLFIYIRPAT 261
Cdd:cd15911 161 LKLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTgRQKAFSTCSSHLIVVTIFYGTLIIVYVVPST 240

                       250       260       270
                ....*....|....*....|....*....|
gi 47577443 262 TYPED--KVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15911 241 NTSRDlnKVFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

26-298

3.06e-86

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 260.33 E-value: 3.06e-86

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  26 FPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFF 105
Cdd:cd15411   4 FVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIAL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 106 GGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15411  84 ATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 186 ACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATTYP 264
Cdd:cd15411 164 SCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTIlKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSSYS 243

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577443 265 E--DKVFALFYTILAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15411 244 LgqDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

28-296

3.44e-86

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 260.18 E-value: 3.44e-86

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  28 LFLFC-----YISILGGN-MFILISITYSQLvQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFT 101
Cdd:cd15421   1 LFLFSlilliFLVALTGNaLLILLIWLDSRL-HTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 102 MHFFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYP 181
Cdd:cd15421  80 FLTLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPA 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 182 LLTLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPA 260
Cdd:cd15421 160 LLKLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVlRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPG 239

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47577443 261 TTY--PEDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15421 240 SYHspEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

23-289

8.32e-86

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 258.73 E-value: 8.32e-86

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  23 TLCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTM 102
Cdd:cd15232   1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 103 HFFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPL 182
Cdd:cd15232  81 TWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 183 LTLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPAT 261
Cdd:cd15232 161 LLLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSIlRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 47577443 262 TYP--EDKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15232 241 SYSpeKDKVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

23-289

1.06e-85

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 258.70 E-value: 1.06e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  23 TLCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTM 102
Cdd:cd15918   1 QLLFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 103 HFFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPL 182
Cdd:cd15918  81 LLFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 183 LTLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTIRAYP-AESRRKALSTCSSHVTVVILFFVPVLFIYIRPAT 261
Cdd:cd15918 161 LKLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPsAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 47577443 262 TYP--EDKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15918 241 SHSasKDSVAAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

10-299

1.75e-85

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 258.74 E-value: 1.75e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  10 FILLGLSQNKKIKTLCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNI 89
Cdd:cd15410   1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  90 ISYTSCMLQLFTMHFFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGH 169
Cdd:cd15410  81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 170 NEMDHYFCDIYPLLTLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILF 248
Cdd:cd15410 161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTIlRIRSAEGRQKAFSTCASHLTAITIF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 47577443 249 FVPVLFIYIRPATTYP--EDKVFALFYTILAPMFNPLIYTLRNTEMKNALRKV 299
Cdd:cd15410 241 HGTILFMYCRPSSSYSldTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKL 293

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

24-289

1.91e-85

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 257.80 E-value: 1.91e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  24 LCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMH 103
Cdd:cd15912   2 LLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 104 FFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15912  82 FLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 184 TLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTIRAYP-AESRRKALSTCSSHVTVVILFFVPVLFIYIRPATT 262
Cdd:cd15912 162 KLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPsASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQS 241

                       250       260
                ....*....|....*....|....*....
gi 47577443 263 YPED--KVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15912 242 SSLDlnKVVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

24-289

3.50e-85

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 257.00 E-value: 3.50e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  24 LCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMH 103
Cdd:cd15227   2 LHFVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 104 FFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15227  82 FFAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 184 TLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTIRAYP-AESRRKALSTCSSHVTVVILFFVPVLFIYIRPATT 262
Cdd:cd15227 162 KLSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPsAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSD 241

                       250       260
                ....*....|....*....|....*....
gi 47577443 263 YPE--DKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15227 242 SPSllDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

23-289

4.02e-85

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 257.20 E-value: 4.02e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  23 TLCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTM 102
Cdd:cd15237   1 ILLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 103 HFFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPL 182
Cdd:cd15237  81 LALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 183 LTLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPAT 261
Cdd:cd15237 161 LKLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATIlRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 47577443 262 TYPE--DKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15237 241 THSPdqDKMISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

24-289

1.12e-84

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 255.82 E-value: 1.12e-84

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  24 LCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMH 103
Cdd:cd15937   2 LLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 104 FFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15937  82 FLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 184 TLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTIRAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATTY 263
Cdd:cd15937 162 KLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRSF 241

                       250       260
                ....*....|....*....|....*.
gi 47577443 264 PEDKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15937 242 PMDKVVAVFHTVIFPLLNPMIYTLRN 267

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

10-298

3.73e-84

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 255.44 E-value: 3.73e-84

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  10 FILLGLSQNKKIKTLCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNI 89
Cdd:cd15945   1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  90 ISYTSCMLQLFTMHFFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGH 169
Cdd:cd15945  81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 170 NEMDHYFCDIYPLLTLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILF 248
Cdd:cd15945 161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVlKIRSAEGRFKAFSTCASHLTAVGLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 47577443 249 FVPVLFIYIRPATTYP--EDKVFALFYTILAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15945 241 YGTLLFMYLRPSSSYSldTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

26-298

2.67e-83

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 252.67 E-value: 2.67e-83

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  26 FPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFF 105
Cdd:cd15416   4 FVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 106 GGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15416  84 GTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 186 ACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATTYP 264
Cdd:cd15416 164 SCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAIlRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSYS 243

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577443 265 ED--KVFALFYTILAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15416 244 MDqnKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

25-298

6.44e-83

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 251.86 E-value: 6.44e-83

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  25 CFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHF 104
Cdd:cd15413   3 LFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 105 FGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLT 184
Cdd:cd15413  83 FIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLA 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 185 LACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATTY 263
Cdd:cd15413 163 LSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAIlRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSSH 242

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47577443 264 P--EDKVFALFYTILAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15413 243 SldTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

24-298

9.00e-83

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 251.46 E-value: 9.00e-83

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  24 LCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMH 103
Cdd:cd15419   2 LLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 104 FFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15419  82 LFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 184 TLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRP-AT 261
Cdd:cd15419 162 KLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTIlRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPgAV 241

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 47577443 262 TYPE-DKVFALFYTILAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15419 242 SSPEqSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

14-299

5.20e-82

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 249.98 E-value: 5.20e-82

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  14 GLSQNKKIKTLCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYT 93
Cdd:cd15406   1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  94 SCMLQLFTMHFFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMD 173
Cdd:cd15406  81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 174 HYFCDIYPLLTLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPV 252
Cdd:cd15406 161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSIlRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 47577443 253 LFIYIRPATTYP--EDKVFALFYTILAPMFNPLIYTLRNTEMKNALRKV 299
Cdd:cd15406 241 IFMYLKPSSSSSmtQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

26-289

6.84e-81

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 246.45 E-value: 6.84e-81

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  26 FPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFF 105
Cdd:cd15915   4 FVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 106 GGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15915  84 GSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 186 ACTNTSRVGLLVVANTGMMGLVTFLVLMWSY----SFILYTIRAypAESRRKALSTCSSHVTVVILFFVPVLFIYIRPAT 261
Cdd:cd15915 164 ACGDTSLNLWLLNIVTGSIALGTFILTLLSYiyiiSFLLLKVRS--KEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSS 241

                       250       260       270
                ....*....|....*....|....*....|
gi 47577443 262 --TYPEDKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15915 242 gdSLEQDRIVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

23-289

5.44e-80

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 243.82 E-value: 5.44e-80

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  23 TLCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTM 102
Cdd:cd15914   1 LLLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 103 HFFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPL 182
Cdd:cd15914  81 HSLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 183 LTLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPAT 261
Cdd:cd15914 161 LSLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVlKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSK 240

                       250       260       270
                ....*....|....*....|....*....|
gi 47577443 262 TYPE--DKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15914 241 SYSLdyDRAIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

26-296

1.95e-79

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 242.69 E-value: 1.95e-79

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  26 FPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFF 105
Cdd:cd15429   4 FVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLAL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 106 GGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15429  84 GGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 186 ACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATTYP 264
Cdd:cd15429 164 ACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAIlRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGSS 243

                       250       260       270
                ....*....|....*....|....*....|....
gi 47577443 265 --EDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15429 244 alQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

26-299

4.45e-79

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 242.33 E-value: 4.45e-79

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  26 FPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFF 105
Cdd:cd15414   4 FLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 106 GGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15414  84 VAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLSL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 186 ACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATTYP 264
Cdd:cd15414 164 SCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAIlRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSSSS 243

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47577443 265 --EDKVFALFYTILAPMFNPLIYTLRNTEMKNALRKV 299
Cdd:cd15414 244 ldLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRT 280

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

23-296

1.08e-78

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 240.80 E-value: 1.08e-78

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  23 TLCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTM 102
Cdd:cd15228   1 TILFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 103 HFFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPL 182
Cdd:cd15228  81 HFLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 183 LTLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPAT 261
Cdd:cd15228 161 LKLACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISIlKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTP 240

                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577443 262 TYPEDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15228 241 SPVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

23-298

1.15e-78

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 240.77 E-value: 1.15e-78

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  23 TLCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTM 102
Cdd:cd15409   1 VPLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 103 HFFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPL 182
Cdd:cd15409  81 GFSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 183 LTLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPAT 261
Cdd:cd15409 161 LKISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTIlKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSS 240

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47577443 262 TYP--EDKVFALFYTILAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15409 241 LYAldQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

26-289

1.30e-77

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 237.91 E-value: 1.30e-77

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  26 FPLFLFCYISILGGNMF-ILISITYSQLvQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHF 104
Cdd:cd15947   4 FVVVLIFYLLTLLGNTAiILLSLLDPRL-HTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLW 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 105 FGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLT 184
Cdd:cd15947  83 LGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 185 LACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATTY 263
Cdd:cd15947 163 LACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVlRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSY 242

                       250       260
                ....*....|....*....|....*...
gi 47577443 264 PED--KVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15947 243 SQDqgKFISLFYTVVTPTLNPLIYTLRN 270

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

26-298

1.85e-77

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 237.70 E-value: 1.85e-77

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  26 FPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFF 105
Cdd:cd15415   4 FMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 106 GGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15415  84 VTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 186 ACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATTYP 264
Cdd:cd15415 164 SCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAIlRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQYS 243

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577443 265 --EDKVFALFYTILAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15415 244 leQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

26-289

3.99e-77

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 236.74 E-value: 3.99e-77

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  26 FPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFF 105
Cdd:cd15431   4 FVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 106 GGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFqNLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15431  84 GITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVI-PVLTMPLHFCGPNVINHFFCEVQALLKL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 186 ACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATTYP 264
Cdd:cd15431 163 ACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVlRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSKSS 242

                       250       260
                ....*....|....*....|....*..
gi 47577443 265 --EDKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15431 243 sdQDKIISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

24-296

1.02e-76

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 235.81 E-value: 1.02e-76

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  24 LCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLI-IERNIISYTSCMLQLFTM 102
Cdd:cd15916   2 LLFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLePGGKVISFGGCVAQLYFF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 103 HFFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPL 182
Cdd:cd15916  82 HFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 183 LTLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPAT 261
Cdd:cd15916 162 LKLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAIlRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGS 241

                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577443 262 TYPEDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15916 242 KEALDGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

10-299

2.73e-74

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 230.44 E-value: 2.73e-74

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  10 FILLGLSQNKKIKTLCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNI 89
Cdd:cd15944   1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  90 ISYTSCMLQLFTMHFFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGH 169
Cdd:cd15944  81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 170 NEMDHYFCDIYPLLTLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILF 248
Cdd:cd15944 161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAIlRMRSAEGRRKAFSTCASHFTGVTLF 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 47577443 249 FVPVLFIYIRPATTYP--EDKVFALFYTILAPMFNPLIYTLRNTEMKNALRKV 299
Cdd:cd15944 241 YGTVIFMYLRPTSVYSldQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKL 293

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

24-296

3.07e-74

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 229.52 E-value: 3.07e-74

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  24 LCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMH 103
Cdd:cd15420   2 LLFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 104 FFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15420  82 ALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 184 TLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATT 262
Cdd:cd15420 162 KLACADTWINEILIFAGCVFILLGPFSLILISYLHILAAIlKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577443 263 YPE--DKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15420 242 NSAeqEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

24-289

2.04e-73

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 227.17 E-value: 2.04e-73

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  24 LCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMH 103
Cdd:cd15224   2 LLFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 104 FFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15224  82 SLACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 184 TLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTIRAYP-AESRRKALSTCSSHVTVVILFFVPVLFIYIRPATT 262
Cdd:cd15224 162 NLSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPsATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAI 241

                       250       260
                ....*....|....*....|....*....
gi 47577443 263 YPED--KVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15224 242 SSFDsnKLVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

28-296

4.36e-73

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 226.49 E-value: 4.36e-73

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  28 LFLFCYISILGGNMFILISITYSQLvQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGG 107
Cdd:cd15434   7 VLIFYLLTLVGNTTIILVSCLDSRL-HTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALGLGG 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 108 IEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTLAC 187
Cdd:cd15434  86 TECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALIKLAC 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 188 TNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYT-IRAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATTYPED 266
Cdd:cd15434 166 VDTTAYEATIFALGVFILLFPLSLILVSYGYIARAvLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSVSQD 245

                       250       260       270
                ....*....|....*....|....*....|..
gi 47577443 267 --KVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15434 246 qgKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

24-298

6.76e-73

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 226.13 E-value: 6.76e-73

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  24 LCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMH 103
Cdd:cd15412   2 LLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 104 FFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15412  82 ALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 184 TLACTNT--SRVGLLVVANTGMMGlvTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPA 260
Cdd:cd15412 162 KLSCSDTyvKETAMFIVAGFNLSS--SLLIILISYLFILIAIlRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPP 239

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 47577443 261 T--TYPEDKVFALFYTILAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15412 240 SeeSVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

26-298

1.20e-72

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 225.76 E-value: 1.20e-72

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  26 FPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFF 105
Cdd:cd15407   4 FIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 106 GGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15407  84 ATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLAL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 186 ACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATTYP 264
Cdd:cd15407 164 SCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITIlRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSHS 243

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577443 265 --EDKVFALFYTILAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15407 244 mdTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

23-289

1.68e-72

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 224.94 E-value: 1.68e-72

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  23 TLCFPLFLFCYISILGGNMF-ILISITYSQLvQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFT 101
Cdd:cd15430   1 ILLFVLCLIMYLVILLGNGVlIIITILDSHL-HTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 102 MHFFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYP 181
Cdd:cd15430  80 SLAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILA 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 182 LLTLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPA 260
Cdd:cd15430 160 VLKLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTIlRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPK 239

                       250       260       270
                ....*....|....*....|....*....|.
gi 47577443 261 T--TYPEDKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15430 240 SknAQISDKLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

27-296

2.82e-71

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 221.92 E-value: 2.82e-71

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  27 PLFLF---CYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMH 103
Cdd:cd15942   2 PLFLFflvVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 104 FFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15942  82 FLGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAML 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 184 TLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATT 262
Cdd:cd15942 162 KLACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAIlKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQ 241

                       250       260       270
                ....*....|....*....|....*....|....
gi 47577443 263 YPEDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15942 242 DPLDGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

24-296

3.94e-70

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 218.89 E-value: 3.94e-70

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  24 LCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMH 103
Cdd:cd15233   2 VLFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 104 FFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15233  82 LLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLF 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 184 TLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATT 262
Cdd:cd15233 162 QLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVlRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSV 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577443 263 YP--EDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15233 242 YSsdKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

24-296

2.45e-69

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 216.91 E-value: 2.45e-69

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  24 LCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMH 103
Cdd:cd15424   2 LLFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIAL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 104 FFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15424  82 SLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 184 TLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRP--A 260
Cdd:cd15424 162 KLACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVlQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPrsG 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577443 261 TTYPEDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15424 242 STPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

26-296

2.55e-69

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 216.90 E-value: 2.55e-69

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  26 FPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFF 105
Cdd:cd15405   4 FFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 106 GGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15405  84 VISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 186 ACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATTYP 264
Cdd:cd15405 164 SCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNIlHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVGS 243

                       250       260       270
                ....*....|....*....|....*....|....
gi 47577443 265 --EDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15405 244 vnQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

24-296

2.78e-69

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 217.02 E-value: 2.78e-69

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  24 LCFPLFLFCYISILGGNMFILISI-TYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLI-IERNIISYTSCMLQLFT 101
Cdd:cd15941   2 LFFLLFLLIYLLTVLGNLLILLTIgSDPHLHGLPMYHFLGHLSFLDACLSSVTVPKVLAGLLtLSGRTISFEGCVVQLYA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 102 MHFFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYP 181
Cdd:cd15941  82 FHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPP 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 182 LLTLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPA 260
Cdd:cd15941 162 VLKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVlRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577443 261 TTYPEDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15941 242 SSQAGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

26-296

5.57e-69

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 215.90 E-value: 5.57e-69

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  26 FPLFLFCY-ISILGGNMFILISITYSQLvQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHF 104
Cdd:cd15234   4 FGLFLSMYlVTVLGNLLIILAVSSDSHL-HTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 105 FGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLT 184
Cdd:cd15234  83 FGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 185 LACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTIRAYP-AESRRKALSTCSSHVTVVILFFVPVLFIYIRPATTY 263
Cdd:cd15234 163 LACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPsSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVTH 242

                       250       260       270
                ....*....|....*....|....*....|....*
gi 47577443 264 PEDK--VFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15234 243 SSRKtaVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

26-299

1.30e-68

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 215.42 E-value: 1.30e-68

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  26 FPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFF 105
Cdd:cd15418   5 FVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 106 GGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15418  85 AYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLVKL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 186 ACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATTY- 263
Cdd:cd15418 165 ACDDTRVYELILYFILGFNVIAPTALILASYTFILAAIlRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPSSSHt 244

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47577443 264 PE-DKVFALFYTILAPMFNPLIYTLRNTEMKNALRKV 299
Cdd:cd15418 245 PDrDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

23-296

1.77e-68

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 215.03 E-value: 1.77e-68

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  23 TLCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTM 102
Cdd:cd15432   1 MVLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 103 HFFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPL 182
Cdd:cd15432  81 LGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPAL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 183 LTLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPAT 261
Cdd:cd15432 161 LKLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVlRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPS 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 47577443 262 TYPED--KVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15432 241 NSSHDrgKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

24-296

6.91e-67

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 210.80 E-value: 6.91e-67

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  24 LCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMH 103
Cdd:cd15428   2 LLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 104 FFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15428  82 SFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 184 TLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRP--A 260
Cdd:cd15428 162 KLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVfGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPksS 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577443 261 TTYPEDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15428 242 TSKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

24-289

6.73e-64

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 202.71 E-value: 6.73e-64

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  24 LCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMH 103
Cdd:cd15946   2 ILFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 104 FFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15946  82 ALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 184 TLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATT 262
Cdd:cd15946 162 KLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAIlKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSN 241

                       250       260
                ....*....|....*....|....*....
gi 47577443 263 Y-PE-DKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15946 242 YsPErDKKISLFYNVFTALLNPVIYSLRN 270

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

24-296

2.75e-62

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 198.84 E-value: 2.75e-62

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  24 LCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMH 103
Cdd:cd15236   2 VFFALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFI 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 104 FFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15236  82 FFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 184 TLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTIRAYP-AESRRKALSTCSSHVTVVILFFVPVLFIYIRPATT 262
Cdd:cd15236 162 KLSCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPsTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSN 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577443 263 YPEDK--VFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15236 242 NSSDKdiVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

23-289

9.82e-62

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 197.15 E-value: 9.82e-62

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  23 TLCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTM 102
Cdd:cd15913   1 ILLFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 103 HFFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPL 182
Cdd:cd15913  81 FSLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 183 LTLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYT-IRAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPAT 261
Cdd:cd15913 161 LALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAvLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGS 240

                       250       260       270
                ....*....|....*....|....*....|
gi 47577443 262 TYPED--KVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15913 241 GNSTGmqKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

24-296

4.71e-59

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 190.77 E-value: 4.71e-59

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  24 LCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMH 103
Cdd:cd15433   2 VLFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 104 FFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15433  82 ALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 184 TLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATT 262
Cdd:cd15433 162 KLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVlRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHR 241

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 47577443 263 YPED--KVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15433 242 YSQAhgKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

29-296

6.23e-56

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 182.49 E-value: 6.23e-56

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  29 FLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGGI 108
Cdd:cd15223   7 FLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFTAM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 109 EILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTLACT 188
Cdd:cd15223  87 ESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVSLACG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 189 NTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYT-IRAYPAESRRKALSTCSSHVTVVILFFVPVLFIYI--RPATTYPE 265
Cdd:cd15223 167 DTTINSIYGLAVAWLIVGSDIILIFFSYALILRAvLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLtyRFGKTIPP 246

                       250       260       270
                ....*....|....*....|....*....|...
gi 47577443 266 D--KVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15223 247 DvhVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

29-292

4.88e-48

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 162.07 E-value: 4.88e-48

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  29 FLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGGI 108
Cdd:cd15917   7 FCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 109 EILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTLACT 188
Cdd:cd15917  87 ESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 189 NTS--RVGLLVVANTgMMGLVTFLVLMwSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATTYPE 265
Cdd:cd15917 167 DTRvnSIYGLFVALL-IVGFDLLFIAL-SYVLILRAVlQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRFGHHV 244

                       250       260       270
                ....*....|....*....|....*....|.
gi 47577443 266 DK----VFALFYTILAPMFNPLIYTLRNTEM 292
Cdd:cd15917 245 PPhvhiLLANLYLLLPPMLNPIVYGVRTKQI 275

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

29-288

1.20e-46

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 158.35 E-value: 1.20e-46

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  29 FLFC--YISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFG 106
Cdd:cd15950   5 IPFCsmYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFT 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 107 GIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTLA 186
Cdd:cd15950  85 AVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 187 CTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLF-IYIR--PATT 262
Cdd:cd15950 165 CADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVlGLSSKEARLKAFSTCGSHVCVILLFYIPGLLsIYTQrfGQGV 244

                       250       260
                ....*....|....*....|....*..
gi 47577443 263 YPEDKVF-ALFYTILAPMFNPLIYTLR 288
Cdd:cd15950 245 PPHTQVLlADLYLLVPPMLNPIIYGMR 271

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

29-292

1.55e-46

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 158.31 E-value: 1.55e-46

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  29 FLFC--YISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFG 106
Cdd:cd15952   5 FPFCavYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFT 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 107 GIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTLA 186
Cdd:cd15952  85 GMESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 187 CTNTSRVGLLVVANTGMMGLVTFLVLMwSYSFILYTIRAYPA-ESRRKALSTCSSHVTVVILFFVPVLFIYI--RPATTY 263
Cdd:cd15952 165 CASIRINIIYGLFAISVLVLDVILIAL-SYVLILRAVFRLPShDARLKALSTCGSHVCVILAFYTPALFSFLthRFGHNI 243

                       250       260       270
                ....*....|....*....|....*....|.
gi 47577443 264 PE--DKVFALFYTILAPMFNPLIYTLRNTEM 292
Cdd:cd15952 244 PRyiHILLANLYVVLPPMLNPVIYGVRTKQI 274

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

29-288

5.20e-45

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 154.37 E-value: 5.20e-45

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  29 FLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGGI 108
Cdd:cd15221   7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVT 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 109 EILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTLACT 188
Cdd:cd15221  87 ESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 189 NTSR---VGLLVVANTGMMGLVTFLVlmwSYSFILYTIRAYPA-ESRRKALSTCSSHVTVVILFFVPVLFIYI--RPATT 262
Cdd:cd15221 167 DITVniwYGLTVALLTVGLDVVLIAV---SYALILRAVFRLPSkDARLKALSTCGSHVCVILMFYTPAFFSFLthRFGRH 243

                       250       260
                ....*....|....*....|....*...
gi 47577443 263 YPEDK--VFALFYTILAPMFNPLIYTLR 288
Cdd:cd15221 244 IPRHVhiLLANLYVLVPPMLNPIVYGVK 271

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

24-291

3.44e-44

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 152.27 E-value: 3.44e-44

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  24 LCFPLFlFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMH 103
Cdd:cd15222   3 ISIPFC-LLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIH 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 104 FFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15222  82 TFSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVM 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 184 TLACTNT---SRVGLLVVANTgmMGLVTFLVLMwSYSFILYTIRAYPA-ESRRKALSTCSSHVTVVILFFVPV--LFIYI 257
Cdd:cd15222 162 KLACSDTrvnSIYGLFVVLST--MGLDSLLILL-SYVLILKTVLGIASrEERLKALNTCVSHICAVLIFYVPMigLSMVH 238

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 47577443 258 RPAttypeDKVFALFYTILA-------PMFNPLIYTLRNTE 291
Cdd:cd15222 239 RFG-----KHASPLVHVLMAnvyllvpPVLNPIIYSVKTKQ 274

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

29-291

2.70e-43

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 149.72 E-value: 2.70e-43

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  29 FLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGGI 108
Cdd:cd15953   7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 109 EILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTLACT 188
Cdd:cd15953  87 ESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 189 NT--SRVGLLVVANTGMMGLVTFLVLmwSYSFILYTI-RAYPAESRRKALSTCSSHVTVVILFFVPVLFIYI--RPATTY 263
Cdd:cd15953 167 DTtiNRIYGLVVALLVVGLDLLLIAL--SYALIIRAVlRLSSKKARQKALNTCTAHICVILMSYTPALFSFLthRFGQGI 244

                       250       260       270
                ....*....|....*....|....*....|
gi 47577443 264 PE--DKVFALFYTILAPMFNPLIYTLRNTE 291
Cdd:cd15953 245 APhiHIILANLYLLVPPMLNPIIYGVKTKE 274

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

29-292

5.51e-40

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 141.15 E-value: 5.51e-40

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  29 FLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGGI 108
Cdd:cd15956   7 FCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 109 EILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTLACT 188
Cdd:cd15956  87 ESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLACG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 189 NTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTIRAYPA-ESRRKALSTCSSHVTVVILFFVPVLFIYI----RPATTY 263
Cdd:cd15956 167 ATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSpEARGKAFSTCSAHICVILFFYIPGLLSVLmhrfGHSVPS 246

                       250       260
                ....*....|....*....|....*....
gi 47577443 264 PEDKVFALFYTILAPMFNPLIYTLRNTEM 292
Cdd:cd15956 247 AAHVLLSNLYLLLPPALNPIVYGIRTKQI 275

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

29-289

1.58e-39

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 139.79 E-value: 1.58e-39

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  29 FLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGGI 108
Cdd:cd15951   7 FCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 109 EILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTLACT 188
Cdd:cd15951  87 ESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 189 NT---SRVGLLVVANTGmmGLVTFLVLMwSYSFILYTIRAYPA-ESRRKALSTCSSHVTVVILFFVPVLFIYIRPATTYP 264
Cdd:cd15951 167 DTrvsRAYGLSVAFLVG--GLDVIFIAV-SYIQILRAVFKLPSkEARLKTFGTCGSHICVILVFYIPALFSFLTHRFGHN 243

                       250       260
                ....*....|....*....|....*....
gi 47577443 265 EDKVFALF----YTILAPMFNPLIYTLRN 289
Cdd:cd15951 244 VPPHVHILianvYLLVPPMLNPIIYGVRT 272

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

29-301

5.29e-39

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 138.79 E-value: 5.29e-39

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443    29 FLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGGI 108
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443   109 EILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTLACT 188
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443   189 NTSR---VGLLVVANTgmMGLVTFLVLMwSYSFILYTIRAYPA-ESRRKALSTCSSHVTVVILFFVPVLFIYI--RPATT 262
Cdd:pfam13853 161 DIKVnniYGLFVVTST--FGIDSLLIVL-SYGLILRTVLGIASrEGRLKALNTCGSHVCAVLAFYTPMIGLSMvhRFGHN 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 47577443   263 YPE--DKVFALFYTILAPMFNPLIYTLRNTEMKNALRKVWC 301
Cdd:pfam13853 238 VPPllQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRMLL 278

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

8-293

5.25e-37

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 133.75 E-value: 5.25e-37

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443   8 TEFILLGLSQNKKIKTLCFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIER 87
Cdd:cd15949   2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  88 NIISYTSCMLQLFTMHFFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFC 167
Cdd:cd15949  82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 168 GHNEMDHYFCDIYPLLTLACTNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTIRAYP-AESRRKALSTCSSHVTVVI 246
Cdd:cd15949 162 RTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLAtSEARLKTFGTCVSHVCAIL 241

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 47577443 247 LFFVPV----LFIYIRPATTYPEDKVFALFYTILAPMFNPLIYTLRNTEMK 293
Cdd:cd15949 242 AFYVPIavssLIHRFGQNVPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

29-293

2.78e-36

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 131.57 E-value: 2.78e-36

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  29 FLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGGI 108
Cdd:cd15948   8 FCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIM 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 109 EILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTLACT 188
Cdd:cd15948  88 ESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLACG 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 189 NTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTIRAYPA-ESRRKALSTCSSHVTVVILFFVPVLF---IYIRPATTYP 264
Cdd:cd15948 168 DTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASkEEQLKAFGTCGSHICAILVFYTPVVLsstMHRFARHVAP 247

                       250       260       270
                ....*....|....*....|....*....|
gi 47577443 265 EDKVF-ALFYTILAPMFNPLIYTLRNTEMK 293
Cdd:cd15948 248 HVHILlANFYLLFPPMMNPIVYGVKTKQIR 277

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

39-285

1.86e-30

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 115.47 E-value: 1.86e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443    39 GNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERN-IISYTSCMLQLFTMHFFGGIEILILTAMA 117
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDwPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443   118 YDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISlpfCGHNEMDHYFCDIYPLLTLACTNtsrvgLLV 197
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWT---LTVPEGNVTVCFIDFPEDLSKPV-----SYT 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443   198 VANTGMMGLVTFLVLMWSYSFILYTIRAYPA--------ESRRKALSTCSSHVTVVILFFVPVLFIYIRPATTYPEDKV- 268
Cdd:pfam00001 153 LLISVLGFLLPLLVILVCYTLIIRTLRKSASkqkssertQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSr 232

                         250       260
                  ....*....|....*....|....
gi 47577443   269 -------FALFYTILAPMFNPLIY 285
Cdd:pfam00001 233 lldkalsVTLWLAYVNSCLNPIIY 256

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

29-292

1.43e-29

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 113.76 E-value: 1.43e-29

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  29 FLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGGI 108
Cdd:cd15954   7 FCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGM 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 109 EILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTLACT 188
Cdd:cd15954  87 ESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 189 NTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTIRAYP-AESRRKALSTCSSHVTVVILFFVPVLFIYIRPA-----TT 262
Cdd:cd15954 167 NIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSsKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRfgghhIT 246

                       250       260       270
                ....*....|....*....|....*....|
gi 47577443 263 YPEDKVFALFYTILAPMFNPLIYTLRNTEM 292
Cdd:cd15954 247 PHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

26-292

4.49e-26

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 104.47 E-value: 4.49e-26

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  26 FPLFLFCYISILGgNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFF 105
Cdd:cd15955   5 IPFCIMFLLAVLG-NCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 106 GGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAM-VTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLT 184
Cdd:cd15955  84 QAFESGILLAMALDRYVAICHPLRHSSILTPQVLLGIgVLVVVRAVVLIIPCPLLIKLRLHHFRSTVISHSYCEHMAVVK 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 185 LACTNT--SRVGLLVVANTGMMGLVTFLVLmwSYSFILYTIRAYPA-ESRRKALSTCSSHVTVVILFFVPVLFIY----- 256
Cdd:cd15955 164 LAADDVrvNKIYGLFVAFSILGFDIIFITT--SYALIFRAVFRLPQkEARLKAFNTCTAHIFVFLLFYTLAFFSFfahrf 241

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47577443 257 ---IRPATTYpedkVFALFYTILAPMFNPLIYTLRNTEM 292
Cdd:cd15955 242 ghhVAPYVHI----LLSNLYLLVPPVLNPIVYGVKTKQI 276

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

28-289

8.25e-21

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 90.04 E-value: 8.25e-21

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  28 LFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGG 107
Cdd:cd00637   4 LYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 108 IEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSffqnllaiSLPFCGHNEMDHYFCDIYpllTLAC 187
Cdd:cd00637  84 ASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLA--------LPPLLGWGVYDYGGYCCC---CLCW 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 188 TNTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTIRAYPAESRRKALSTCSSH------------VTVVILFFV---PV 252
Cdd:cd00637 153 PDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRrrrrerkvtktlLIVVVVFLLcwlPY 232

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 47577443 253 LFIYIRPATTYPEDKVFALFYTI------LAPMFNPLIYTLRN 289
Cdd:cd00637 233 FILLLLDVFGPDPSPLPRILYFLalllayLNSAINPIIYAFFN 275

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

36-296

1.48e-11

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 63.35 E-value: 1.48e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  36 ILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGGIEILILTA 115
Cdd:cd14967  13 TVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCCTASILNLCA 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 116 MAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFfqnllaisLPFCGHNEMDHYFCDIYPLltlaCTNTSRVGL 195
Cdd:cd14967  93 ISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISL--------PPLVGWRDETQPSVVDCEC----EFTPNKIYV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 196 LVVANTGMMglVTFLVLMWSYSFILYTiraypAESRRKALSTcsshVTVVILFFV----PVLFIYIRPA---TTYPEDKV 268
Cdd:cd14967 161 LVSSVISFF--IPLLIMIVLYARIFRV-----ARRELKAAKT----LAIIVGAFLlcwlPFFIIYLVSAfcpPDCVPPIL 229

                       250       260       270
                ....*....|....*....|....*....|
gi 47577443 269 FALFYTI--LAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd14967 230 YAVFFWLgyLNSALNPIIYALFNRDFRRAF 259

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

28-296

1.26e-10

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 61.07 E-value: 1.26e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  28 LFLFCYISILGgNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGG 107
Cdd:cd14969   7 LSLIGVLGVVL-NGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGL 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 108 IEILILTAMAYDRYVAICKPLHYTIIMSRgRCQAMVTACCAGAFIHSFFqnllaislPFCGHN----EMDHYFCDIYPLL 183
Cdd:cd14969  86 VSISTLAALAFERYLVIVRPLKAFRLSKR-RALILIAFIWLYGLFWALP--------PLFGWSsyvpEGGGTSCSVDWYS 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 184 TLACTNTSRVGLLVVANtgmmgLVTFLVLMWSYSFILYTIRAYPAESRRKALST-------CSSHVTVVILFFVPVLFIY 256
Cdd:cd14969 157 KDPNSLSYIVSLFVFCF-----FLPLAIIIFCYYKIYRTLRKMSKRAARRKNSAitkrtkkAEKKVAKMVLVMIVAFLIA 231

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 47577443 257 IRP-------ATTYPEDKVFALFYTI------LAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd14969 232 WTPyavvslyVSFGGESTIPPLLATIpalfakSSTIYNPIIYVFMNKQFRRAL 284

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

28-296

3.85e-09

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 56.53 E-value: 3.85e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  28 LFLFCYIS--ILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLiierniisYTSCMLQLFTMHFF 105
Cdd:cd14972   2 LVVAIVLGvfIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVL--------LVSLTPSPATWLLR 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 106 GGIEILILTAMAY-------DRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIhsffqnlLAISLPFCGH-NEMDHYFC 177
Cdd:cd14972  74 KGSLVLSLLASAYsllaiavDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVL-------LALLPVLGWNcVLCDQESC 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 178 -DIYPLLTlactnTSRVGLLVVANTGMMGLVTFL-----VLMWSYSF--ILYTIRAYPAESRRkalsTCSSHVTVVILFF 249
Cdd:cd14972 147 sPLGPGLP-----KSYLVLILVFFFIALVIIVFLyvrifWCLWRHANaiAARQEAAVPAQPST----SRKLAKTVVIVLG 217

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 47577443 250 VPV-----LFIYIRPATTYPEDK------VFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd14972 218 VFLvcwlpLLILLVLDVLCPSVCdiqavfYYFLVLALLNSAINPIIYAFRLKEMRRAV 275

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

39-296

1.01e-07

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 52.26 E-value: 1.01e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  39 GNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPkfLSDLIIERNIISYTSCMLQLFTMHFFGGIEILILTAMAY 118
Cdd:cd14968  17 GNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIP--LAILISLGLPTNFHGCLFMACLVLVLTQSSIFSLLAIAI 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 119 DRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFfqnllaisLPFCG-HNEMDHYFCDIYPLLTLACTNTSRVGLLV 197
Cdd:cd14968  95 DRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGL--------TPMFGwNNGAPLESGCGEGGIQCLFEEVIPMDYMV 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 198 VANTGMMGLVTFLVLMWSYSFILYTIR------------AYPAESRRKALSTCSSHVTVVILFFVPVLFIYIRPATTY-- 263
Cdd:cd14968 167 YFNFFACVLVPLLIMLVIYLRIFRVIRkqlrqiesllrsRRSRSTLQKEVKAAKSLAIILFLFALCWLPLHIINCITLfc 246

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 47577443 264 PEDKV------FALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd14968 247 PECKVpkiltyIAILLSHANSAVNPIVYAYRIRKFRQTF 285

7tmA_Opsin5_neuropsin

cd15074

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...

28-151

2.21e-07

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.

Pssm-ID: 320202 [Multi-domain] Cd Length: 284 Bit Score: 51.51 E-value: 2.21e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  28 LFLFCYISILGGNMFILISITYSQLVQQPMYFFLNyLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGG 107
Cdd:cd15074   7 LTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVN-LAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGC 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 47577443 108 IEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAF 151
Cdd:cd15074  86 CSINTLTAISIYRYLKICHPPYGPKLSRRHVCIVIVAIWLYALF 129

7tmA_Melanopsin

cd15336

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...

39-138

1.38e-06

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320458 [Multi-domain] Cd Length: 290 Bit Score: 48.95 E-value: 1.38e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  39 GNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGGIEILILTAMAY 118
Cdd:cd15336  17 GNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFGITSMITLLAISL 96

                        90       100
                ....*....|....*....|
gi 47577443 119 DRYVAICKPLHYTIIMSRGR 138
Cdd:cd15336  97 DRYLVITKPLASIRWVSKKR 116

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

26-155

1.77e-06

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 48.70 E-value: 1.77e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  26 FPLFLFCYISILG--GNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPK----------FLSDLIierniisyt 93
Cdd:cd15055   2 LLYIVLSSISLLTvlGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMPFsmirsietcwYFGDTF--------- 72

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 47577443  94 sCMLQLFTMHFFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSF 155
Cdd:cd15055  73 -CKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSS 133

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

33-226

2.46e-06

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 48.10 E-value: 2.46e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  33 YISILG-----GNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGG 107
Cdd:cd15083   6 FILIIGligvvGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGI 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 108 IEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMvtacCAGAFIHSffqnLLAISLPFCGHNE--MDHYFC----DIyp 181
Cdd:cd15083  86 MSINTLAAIAVDRYLVITRPMKASVRISHRRALIV----IAVVWLYS----LLWVLPPLFGWSRyvLEGLLTscsfDY-- 155

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 47577443 182 lltLACTNTSRVGLLVVANTGMmgLVTFLVLMWSYSFILYTIRAY 226
Cdd:cd15083 156 ---LSRDDANRSYVICLLIFGF--VLPLLIIIYCYSFIFRAVRRH 195

7tmA_Parapinopsin

cd15075

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...

30-128

3.84e-06

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.

Pssm-ID: 320203 [Multi-domain] Cd Length: 279 Bit Score: 47.46 E-value: 3.84e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  30 LFCYISILGGNMFILISITYSQLvQQPMYFFLNYLALSDLCytstvTPKFLSDLIIERNIISY-----TSCMLQLFTMHF 104
Cdd:cd15075   9 VFSIASVVLNATVIIVTLRHKQL-RQPLNYALVNLAVADLG-----TTVFGGLLSVVTNAVGYfnlgrVGCVLEGFAVAF 82

                        90       100
                ....*....|....*....|....
gi 47577443 105 FGGIEILILTAMAYDRYVAICKPL 128
Cdd:cd15075  83 FGIAALCTVAVIAVDRLFVVCKPL 106

7tmA_Prostanoid_R

cd14981

G protein-coupled receptors for prostanoids, member of the class A family of ...

100-176

5.64e-06

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.

Pssm-ID: 320112 [Multi-domain] Cd Length: 288 Bit Score: 47.24 E-value: 5.64e-06

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47577443 100 FTMHFFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAfihsffqnLLAISLPFCGHNEMDHYF 176
Cdd:cd14981  81 FMMSFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFA--------LLIASLPLLGLGSYVLQY 149

7tmA_Octopamine_R

cd15063

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...

36-295

7.40e-06

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.

Pssm-ID: 320191 [Multi-domain] Cd Length: 266 Bit Score: 46.72 E-value: 7.40e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  36 ILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGGIEILILTA 115
Cdd:cd15063  14 VVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWMCTASILNLCA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 116 MAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFfqnllaisLPFCGHNEMDHYFCD--IYPLLTLACTNTSRV 193
Cdd:cd15063  94 ISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICF--------PPLVGWNDGKDGIMDysGSSSLPCTCELTNGR 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 194 GLLVVANTGMMGLVTFLVLMWSYsfilytiRAYPAESRR-KALSTCSSHVTVVILFFVPVLFIYIRPATTYP--EDKVFA 270
Cdd:cd15063 166 GYVIYSALGSFYIPMLVMLFFYF-------RIYRAARMEtKAAKTVAIIVGCFIFCWLPFFTVYLVRAFCEDciPPLLFS 238

                       250       260
                ....*....|....*....|....*..
gi 47577443 271 LFYTI--LAPMFNPLIYTLRNTEMKNA 295
Cdd:cd15063 239 VFFWLgyCNSALNPCIYALFSRDFRFA 265

7tmA_GPR119_R_insulinotropic_receptor

cd15104

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...

34-296

8.41e-06

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320232 [Multi-domain] Cd Length: 283 Bit Score: 46.60 E-value: 8.41e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  34 ISILGGNMFILISIT-YSQLVQQPMYFFLNYLALSDLCyTSTVTPKFLSDLIIERNIISY-TSCMLQLFTMHFFGGIEIL 111
Cdd:cd15104  11 PLIITGNLLVIVALLkLIRKKDTKSNCFLLNLAIADFL-VGLAIPGLATDELLSDGENTQkVLCLLRMCFVITSCAASVL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 112 ILTAMAYDRYVAICKPLHYTIIMSRGRcqamVTACCAGAFIHSFFQNLLAISLPFC---GHNEMDHYFCDIYP--LLTLA 186
Cdd:cd15104  90 SLAAIAFDRYLALKQPLRYKQIMTGKS----AGALIAGLWLYSGLIGFLPLISPQFqqtSYKGKCSFFAAFHPrvLLVLS 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 187 CtntsrvgllvvantgMMGLVTFLVLMWSYSFILYTIRAY-------------PAESRR-----KALSTCSSHVTVVILF 248
Cdd:cd15104 166 C---------------MVFFPALLLFVFCYCDILKIARVHsraiykvehalarQIHPRRtlsdfKAARTVAVLIGCFLLS 230

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 47577443 249 FVPVLFIYIRPATT-----YPEDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15104 231 WLPFQITGLVQALCdecklYDVLEDYLWLLGLCNSLLNPWIYAFWQKEVRRAL 283

7tmA_Beta3_AR

cd15959

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...

31-143

1.89e-05

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320625 [Multi-domain] Cd Length: 302 Bit Score: 45.67 E-value: 1.89e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  31 FCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGGIEI 110
Cdd:cd15959   9 LAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVTASI 88

                        90       100       110
                ....*....|....*....|....*....|...
gi 47577443 111 LILTAMAYDRYVAICKPLHYTIIMSRGRCQAMV 143
Cdd:cd15959  89 ETLCAIAVDRYLAITNPLRYEALVTKRRARTAV 121

7tmA_Chemokine_R

cd14984

classical and atypical chemokine receptors, member of the class A family of ...

26-250

3.82e-05

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.

Pssm-ID: 341319 [Multi-domain] Cd Length: 278 Bit Score: 44.51 E-value: 3.82e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  26 FPLFLFCYISILG--GNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVtPKFLSDLIIErNIISYTSC--MLQLFT 101
Cdd:cd14984   2 FLPVLYSLVFLLGlvGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLTL-PFWAVYAADG-WVFGSFLCklVSALYT 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 102 MHFFGGIeiLILTAMAYDRYVAICKPLHYtiimSRGRCQAMVTACCAGAFIHSffqnlLAISLPFC----GHNEMDHYFC 177
Cdd:cd14984  80 INFYSGI--LFLACISIDRYLAIVHAVSA----LRARTLLHGKLTCLGVWALA-----LLLSLPEFifsqVSEENGSSIC 148

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 47577443 178 D-IYPLLTLActnTSRVGLLVVANTGMMgLVTFLVLMWSYSFILYTIRAYPAESRRKALSTCsshVTVVILFFV 250
Cdd:cd14984 149 SyDYPEDTAT---TWKTLLRLLQNILGF-LLPLLVMLFCYSRIIRTLLRARNHKKHRALRVI---FAVVVVFFL 215

7tmA_Cannabinoid_R

cd15099

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...

19-296

4.59e-05

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 320227 [Multi-domain] Cd Length: 281 Bit Score: 44.44 E-value: 4.59e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  19 KKIKTLCFPLFLFCYISilggNMFILISITYSQ-LVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLII----ERNIISYT 93
Cdd:cd15099   1 KAIAVLCFLAGPVTFLE----NILVLLTILSSTaLRRRPSYLFIGSLALADMLASVIFTISFLDFHVFhqrdSRNLFLFK 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  94 scmLQLFTMHFFGGIEILILTAMayDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFfqnllaisLPFCGHN--E 171
Cdd:cd15099  77 ---LGGVTMAFTASVGSLLLTAL--DRYLCIYQPSNYKLLVTRTRAKVAILLMWCVTIIISF--------LPLMGWRckT 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 172 MDHYFCDIYPLLtlacTNTSRVGLLVVAntgmmgLVTFLVLMWSYSFILYTIRAYPAESRRKALS--------------- 236
Cdd:cd15099 144 WDSPCSRLFPYI----DRHYLASWTGLQ------LVLLFLIIYAYPYILWKAHRHEANMGGPKLGrqqvkgqarmrmdir 213

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 47577443 237 ---TCSSHVTVVILFFVPVLFIYIRPATTYPEDKVFALF-----YTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15099 214 lakTLSLILLVLAICWLPVLAFMLVDVRVTLTNKQKRMFafcsmLCLVNSCVNPIIYALRSRELRGAM 281

7tmA_tyramine_R-like

cd15061

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

34-295

5.15e-05

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320189 [Multi-domain] Cd Length: 256 Bit Score: 43.89 E-value: 5.15e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  34 ISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGGIEILIL 113
Cdd:cd15061  11 IFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDVLLCTASILNL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 114 TAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIhsffqnllAISLPFCGHNEmdHYFCDIYplltlACTNTSRV 193
Cdd:cd15061  91 CCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLL--------ITSPPLVGPSW--HGRRGLG-----SCYYTYDK 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 194 GLLVVANTGMMgLVTFLVLMWSYSFILYTIraypaESRRKALSTCSSHVTVVILFFVPVLFIY-IRPATTYPEDKVFALF 272
Cdd:cd15061 156 GYRIYSSMGSF-FLPLLLMLFVYLRIFRVI-----AKERKTAKTLAIVVGCFIVCWLPFFIMYlIEPFCDCQFSEALSTA 229

                       250       260
                ....*....|....*....|....*.
gi 47577443 273 YTILA---PMFNPLIYTLRNTEMKNA 295
Cdd:cd15061 230 FTWLGyfnSVINPFIYAFYNKDFRRA 255

7tmA_5-HT1_5_7

cd15064

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...

39-295

6.21e-05

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320192 [Multi-domain] Cd Length: 258 Bit Score: 43.86 E-value: 6.21e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  39 GNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGGIEILILTAMAY 118
Cdd:cd15064  17 GNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLDVTCCTASILHLCVIAL 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 119 DRYVAICKPLHYTIIMSRGRCQAMVtaccAGAFIHSFFqnllaISLP----FCGHNEMDHYFCDIyplltlactnTSRVG 194
Cdd:cd15064  97 DRYWAITDAVEYAHKRTPKRAAVMI----ALVWTLSIC-----ISLPplfgWRTPDSEDPSECLI----------SQDIG 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 195 LLVVANTGMMGLVTFLVLmwsysfILYTiRAYPAESR-RKALSTCSSHVTVVIL----FFVPVLFIYIRPATTYPED-KV 268
Cdd:cd15064 158 YTIFSTFGAFYIPLLLML------ILYW-KIYRAAAReRKAAKTLGIILGAFIVcwlpFFLVALIVPLCSHCWIPLAlKS 230

                       250       260
                ....*....|....*....|....*..
gi 47577443 269 FALFYTILAPMFNPLIYTLRNTEMKNA 295
Cdd:cd15064 231 FFLWLGYFNSLINPLIYTFFNKDFRKA 257

7tmA_DmOct-betaAR-like

cd15066

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...

21-145

7.25e-05

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.

Pssm-ID: 320194 [Multi-domain] Cd Length: 265 Bit Score: 43.52 E-value: 7.25e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  21 IKTLCFPLFLfcyISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLF 100
Cdd:cd15066   1 LKGFAMTLII---LAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNS 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 47577443 101 TMHFFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTA 145
Cdd:cd15066  78 LDVYFSTASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLAN 122

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

28-285

7.42e-05

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 43.74 E-value: 7.42e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  28 LFLFCYISI----LGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMH 103
Cdd:cd14993   2 VLIVLYVVVfllaLVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 104 FFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIhsffqnllaISLPFCGHNEMDHYFCDI-YPL 182
Cdd:cd14993  82 VSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAII---------IMLPLLVVYELEEIISSEpGTI 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 183 LTLACT----NTSRVGLLVVANTGMMGLVTFLVLMWSYSFILYTI-RAYPAESRRKALSTCSSH------------VTVV 245
Cdd:cd14993 153 TIYICTedwpSPELRKAYNVALFVVLYVLPLLIISVAYSLIGRRLwRRKPPGDRGSANSTSSRRilrskkkvarmlIVVV 232

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 47577443 246 ILFFV---PVLFIYIRPATTYPEDKVFALFYTILAPMF----------NPLIY 285
Cdd:cd14993 233 VLFALswlPYYVLSILLDFGPLSSEESDENFLLILPFAqllgysnsaiNPIIY 285

7tmA_5-HT7

cd15329

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...

28-146

8.50e-05

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320452 [Multi-domain] Cd Length: 260 Bit Score: 43.41 E-value: 8.50e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  28 LFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIIS------YTSCMLQLFT 101
Cdd:cd15329   6 VLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGeilcdvWISFDVLLCT 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 47577443 102 MhffggiEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTAC 146
Cdd:cd15329  86 A------SILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIV 124

7tmA_Beta1_AR

cd15958

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...

34-156

1.33e-04

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320624 [Multi-domain] Cd Length: 298 Bit Score: 42.97 E-value: 1.33e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  34 ISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPkfLSDLIIERNIISYTSCMLQLFTmhffgGIEILIL 113
Cdd:cd15958  12 LLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVP--FGATLVVRGRWLYGSFFCELWT-----SVDVLCV 84

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 47577443 114 TA-------MAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFF 156
Cdd:cd15958  85 TAsietlcvIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVSFL 134

7tmA_5-HT2B

cd15306

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...

28-138

1.37e-04

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341347 [Multi-domain] Cd Length: 277 Bit Score: 42.90 E-value: 1.37e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  28 LFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNI-ISYTSCMLQLFTMHFFG 106
Cdd:cd15306   6 LILMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAMWpLPLVLCPIWLFLDVLFS 85

                        90       100       110
                ....*....|....*....|....*....|..
gi 47577443 107 GIEILILTAMAYDRYVAICKPLHYTIIMSRGR 138
Cdd:cd15306  86 TASIMHLCAISLDRYIAIKKPIQASQYNSRAT 117

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

37-250

1.42e-04

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 42.61 E-value: 1.42e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  37 LGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYT---------STVTPKFLSDLIIERnIISYtscmLQLFTMHffgg 107
Cdd:cd15196  15 LFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVAlfnvlpqliWDITYRFYGGDLLCR-LVKY----LQVVGMY---- 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 108 IEILILTAMAYDRYVAICKPLHYTIIMSRgRCQAMVTACCAGAFIHSFFQnLLAISLPFCGHnemDHYFCdiYPLLTLAC 187
Cdd:cd15196  86 ASSYVLVATAIDRYIAICHPLSSHRWTSR-RVHLMVAIAWVLSLLLSIPQ-LFIFSYQEVGS---GVYDC--WATFEPPW 158

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47577443 188 TNTSRVGLLVVANTgmmgLVTFLVLMWSYSFILYTIraypaesRRKALSTCSSHVTVVILFFV 250
Cdd:cd15196 159 GLRAYITWFTVAVF----VVPLIILAFCYGRICYVV-------WRAKIKTVKLTLVVVACYIV 210

7tmA_Parietopsin

cd15085

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...

24-143

1.68e-04

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.

Pssm-ID: 320213 [Multi-domain] Cd Length: 280 Bit Score: 42.53 E-value: 1.68e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  24 LCFPLFLFCYISILGGNMFILISITYSQLvQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMH 103
Cdd:cd15085   3 LSFLMFLNATFSIFNNVLVIAVTLKNPQL-RNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVN 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 47577443 104 FFGGIEILILTAMAYDRYVAICKPLHyTIIMSRGR-CQAMV 143
Cdd:cd15085  82 YFGIVSLWSLTLLAYERYNVVCKPMG-GLKLSTKRgYQGLL 121

7tmA_Peropsin

cd15073

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...

28-296

2.37e-04

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.

Pssm-ID: 320201 [Multi-domain] Cd Length: 280 Bit Score: 42.03 E-value: 2.37e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  28 LFLFCYISILGGNMFILISITYSQLVQqPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGG 107
Cdd:cd15073   7 LIVAGIISTISNGIVLVTFVKFRELRT-PTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGM 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 108 IEILILTAMAYDRYVAICKPLHYTiIMSRGRCQAMVTAccagAFIHSFFQNLLAISLPFCGHNEMDHYFCDIypllTLAC 187
Cdd:cd15073  86 ASIGLLTVVAVDRYLTICRPDLGR-KMTTNTYTVMILL----AWTNAFFWAAMPLVGWASYALDPTGATCTI----NWRK 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 188 TNTSRVG-LLVVANTGMMglVTFLVLMWSYSFILYTIRAYPAESRRKALSTCSSH--------VTVVILFFVP-----VL 253
Cdd:cd15073 157 NDSSFVSyTMSVIVVNFI--VPLAVMFYCYYNVSRFVKKVLASDCLESVNIDWTDqndvtkmsVIMIVMFLVAwspysIV 234

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 47577443 254 FIYirpaTTYPEDKVFALFYTILAPMF-------NPLIYTLRNTEMKNAL 296
Cdd:cd15073 235 CLW----ASFGEPKKIPPWMAIIPPLFaksstfyNPCIYVIANKKFRRAI 280

7tmA_Trissin_R

cd15012

trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...

28-128

2.45e-04

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320140 [Multi-domain] Cd Length: 277 Bit Score: 42.05 E-value: 2.45e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  28 LFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGG 107
Cdd:cd15012   5 LYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSYT 84

                        90       100
                ....*....|....*....|.
gi 47577443 108 IEILILTAMAYDRYVAICKPL 128
Cdd:cd15012  85 ASIGILVVISVERYIAILHPL 105

7tmA_GHSR-like

cd15928

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...

24-152

2.67e-04

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.

Pssm-ID: 320594 [Multi-domain] Cd Length: 288 Bit Score: 42.09 E-value: 2.67e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  24 LCFPLFLFCyisiLGGNMFILISITYSQLVQQPMYFFLNYLALSDLcYTSTVTPKFLSDLIIERN-IISYTSCMLQLFTM 102
Cdd:cd15928   6 VCSVLMLVG----ASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDL-LIFLVLPLDLYRLWRYRPwRFGDLLCRLMYFFS 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 47577443 103 HFFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFI 152
Cdd:cd15928  81 ETCTYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIV 130

7tmA_Vasopressin-like

cd14986

vasopressin receptors and its related G protein-coupled receptors, member of the class A ...

37-154

3.41e-04

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.

Pssm-ID: 320117 [Multi-domain] Cd Length: 295 Bit Score: 41.59 E-value: 3.41e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  37 LGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYT-STVTPKFLSDLIIER-------NIISYtscmLQLFTMHffggI 108
Cdd:cd14986  15 LVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAfFTVLTQIIWEATGEWvagdvlcRIVKY----LQVVGLF----A 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 47577443 109 EILILTAMAYDRYVAICKPLHytiiMSRGRCQA--MVTACCAGAFIHS 154
Cdd:cd14986  87 STYILVSMSLDRYQAIVKPMS----SLKPRKRArlMIVVAWVLSFLFS 130

7tmA_alpha2_AR

cd15059

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...

36-165

3.64e-04

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320187 [Multi-domain] Cd Length: 261 Bit Score: 41.56 E-value: 3.64e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  36 ILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGGIEILILTA 115
Cdd:cd15059  14 IIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALDVLFCTASIVNLCA 93

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 47577443 116 MAYDRYVAICKPLHYTIIMSRGRCQAMVTAccagAFIHSffqnlLAISLP 165
Cdd:cd15059  94 ISLDRYWSVTQAVEYNLKRTPRRAKAMIAA----VWIIS-----AVISLP 134

7tmA_Beta_AR

cd15058

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...

24-143

4.90e-04

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320186 [Multi-domain] Cd Length: 305 Bit Score: 41.28 E-value: 4.90e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  24 LCFPLFLFCYIsILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCmlQLFTmh 103
Cdd:cd15058   3 LLLLLALIILA-IVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWC--ELWT-- 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 47577443 104 ffgGIEILILTA-------MAYDRYVAICKPLHYTIIMSRGRCQAMV 143
Cdd:cd15058  78 ---SVDVLCVTAsietlcvIAVDRYIAITRPLRYQVLLTKRRARVIV 121

7tmA_FMRFamide_R-like

cd14978

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...

34-183

6.47e-04

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.

Pssm-ID: 410630 [Multi-domain] Cd Length: 299 Bit Score: 40.69 E-value: 6.47e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  34 ISILG--GNMFILISITySQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYT-----SCMLQLFTMHFFG 106
Cdd:cd14978  10 ICIFGiiGNILNLVVLT-RKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSyfyayFLPYIYPLANTFQ 88

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 47577443 107 GIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFFqNLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd14978  89 TASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLP-RFFEYEVVECENCNNNSYYYVIPTLL 164

7tmA_Adenosine_R_A3

cd15070

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...

39-296

6.97e-04

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.

Pssm-ID: 320198 [Multi-domain] Cd Length: 280 Bit Score: 40.53 E-value: 6.97e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  39 GNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPkfLSDLIIERNIISYTSCMLQLFTMHFFGGIEILILTAMAY 118
Cdd:cd15070  17 GNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIP--LAIVVSLGVTIHFYSCLFMSCLLVVFTHASIMSLLAIAV 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 119 DRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFfqnllaisLPFCGHNEMDHYFCDIYPLLTLACTNTSRVGLLVV 198
Cdd:cd15070  95 DRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGL--------TPMFGWNRKPSLESVNTTPLQCQFTSVMRMDYMVY 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 199 ANTGMMGLVTFLVLMWSYSFILYTIRAYPAES----------RRKALSTCSSHVTVVILFFVPVLFIYIRPATTYPEDKV 268
Cdd:cd15070 167 FSFFTWILIPLVIMCALYVDIFYIIRNKLSQNatgfretgafYGREFKTAKSLALVLFLFAVCWLPLSIINCVVYFNPKV 246

                       250       260       270
                ....*....|....*....|....*....|....
gi 47577443 269 --FALFYTILA----PMFNPLIYTLRNTEMKNAL 296
Cdd:cd15070 247 pkIALYLGILLshanSMMNPIVYACKIKKFKETY 280

7tmA_GnRHR-like

cd15195

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...

39-223

7.11e-04

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.

Pssm-ID: 320323 [Multi-domain] Cd Length: 293 Bit Score: 40.84 E-value: 7.11e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  39 GNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGGIEILILTAMAY 118
Cdd:cd15195  17 GNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAVWNYTVEWLAGDLMCRVMMFLKQFGMYLSSFMLVVIAL 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 119 DRYVAICKPLhyTIIMSRGRCQAMVTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTLactntSRVGLLVV 198
Cdd:cd15195  97 DRVFAILSPL--SANQARKRVKIMLTVAWVLSALCSIPQSFIFSVLRKMPEQPGFHQCVDFGSAPTK-----KQERLYYF 169

                       170       180
                ....*....|....*....|....*
gi 47577443 199 ANTGMMGLVTFLVLMWSYSFILYTI 223
Cdd:cd15195 170 FTMILSFVIPLIITVTCYLLILFEI 194

7tmA_PGI2

cd15141

prostaglandin I2 receptor, member of the class A family of seven-transmembrane G ...

64-233

1.03e-03

prostaglandin I2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin I2 receptor (also called prostacyclin receptor or prostanoid IP receptor) is a class A, G protein-coupled receptor whose endogenous ligand is prostacyclin, which is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and vascular smooth muscle cells (VSMCs). The PGI2 receptor is coupled to both G(s) and G(q) protein subtypes, resulting in increased cAMP formation, phosphoinositide turnover, and Ca2+ signaling. PGI2 receptor activation by prostacyclin induces VSMC differentiation and produces a potent vasodilation and inhibition of platelet aggregation.

Pssm-ID: 320269 [Multi-domain] Cd Length: 301 Bit Score: 40.19 E-value: 1.03e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  64 LALSDLCYTSTVTPKFLSDLIIERNIISYTS----CMLQLFTMHFFGGIEILILTAMAYDRYVAICKPLHYTIIMSRGrc 139
Cdd:cd15141  46 LAATDLLGTCFLSPMVFVSYAQNSSLLGLAAgqplCHLFAFAMTFFGLASMLILFAMAVERCLAISHPYFYAQHSGRR-- 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 140 qamvtaCCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTLACTNTSRVGLLV--VANTGMMGLVTFLVLMWSYS 217
Cdd:cd15141 124 ------LAKLALPAIYAFGALFCALPLLGVGRHKQYCPGTWCFIRMTVPGHREPGSLAfsLLYASLMALLIAAIFLCNGS 197

                       170
                ....*....|....*.
gi 47577443 218 FILYTIRAYPAESRRK 233
Cdd:cd15141 198 VTVSLCRMYRGQKARR 213

7tmA_CB2

cd15341

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...

34-296

1.10e-03

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 320463 [Multi-domain] Cd Length: 279 Bit Score: 40.21 E-value: 1.10e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  34 ISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLsDLIIERNIISYTSCMLQL--FTMHFFGGIEIL 111
Cdd:cd15341  13 LCILENVAVLYLILSSPKLRRKPSYLFIGSLALADFLASVVFACSFV-DFHVFHGVDSSAIFLLKLggVTMSFTASLGSL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 112 ILtaMAYDRYVAICKPLHYTIIMSRGRcqAMVTAccAGAFIHSFFQNLlaisLPFCGHN--EMDHYFCDIYPLLTlacTN 189
Cdd:cd15341  92 LL--MAFDRYVCIYYPSEYKALVTRKR--ALVAL--AVMWVLTALIAY----LPLMGWNccPLNSPCSELFPLIP---ND 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 190 TSRVGLLVVAntgmmglVTFLVLMWSYSFILY------------TIRAYPAESRRKALSTCSSHVTVVILFFV----PVL 253
Cdd:cd15341 159 YLLSWLLLVA-------ILLSGIIYTYGHVLWkahkhvvymekhQDQQGPGNARMRLDVRLAKTLGLVLAVLLicwsPVL 231

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 47577443 254 FIYIRPATTYPEDKVFALF-----YTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15341 232 ALMMHSLFTSLSDHIKKAFafcstLCLVNSMVNPIIYALRSRELRSSL 279

7tmA_Dop1R2-like

cd15067

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...

28-295

1.38e-03

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.

Pssm-ID: 320195 [Multi-domain] Cd Length: 262 Bit Score: 39.65 E-value: 1.38e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  28 LFLFCYISILGgNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPkflsdliieRNIISYTSCMLQLF------T 101
Cdd:cd15067   6 LSLFCLVTVAG-NLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMP---------FSILHEMTGGYWLFgrdwcdV 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 102 MHFFGGI----EILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTAccagAFIHSffqnlLAISLPFCGHNEMdhyfC 177
Cdd:cd15067  76 WHSFDVLastaSILNLCVISLDRYWAITDPISYPSRMTKRRALIMIAL----VWICS-----ALISFPAIAWWRA----V 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 178 DIYPLLTLACTNTSRVGLLVVANTgmmglVTFLVLMWSYSFILYTIraYPAESR-RKALSTCSSHVTVVIL----FFVPV 252
Cdd:cd15067 143 DPGPSPPNQCLFTDDSGYLIFSSC-----VSFYIPLVVMLFTYYRI--YRAAAKeQKAAKTLGIVMGVFILcwlpFFVTN 215

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 47577443 253 LFIYIRPATTYP-EDKVFALFYTI--LAPMFNPLIYTLRNTEMKNA 295
Cdd:cd15067 216 ILIGFCPSNCVSnPDILFPLVTWLgyINSGMNPIIYACSSRDFRRA 261

7tmA_5-HT2A

cd15304

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...

28-145

1.41e-03

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341345 [Multi-domain] Cd Length: 267 Bit Score: 39.53 E-value: 1.41e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  28 LFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTP-KFLSDLIIERNIISYTSCMLQLFTMHFFG 106
Cdd:cd15304   6 LTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPvSMLTILYGYRWPLPSKLCAVWIYLDVLFS 85

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 47577443 107 GIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTA 145
Cdd:cd15304  86 TASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIA 124

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

28-135

1.63e-03

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 39.64 E-value: 1.63e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  28 LFLFCYISIL---GGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLsdliiernIISYTSCMlqlftmhF 104
Cdd:cd15312   3 MYLFMAGAILltvFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSM--------VRSVESCW-------Y 67

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 47577443 105 FGGI---------------EILILTAMAYDRYVAICKPLHYTIIMS 135
Cdd:cd15312  68 FGDLfckihssldmmlsttSIFHLCFIAVDRYYAVCDPLHYRTKIT 113

7tmA_Pinopsin

cd15084

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...

41-128

1.86e-03

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320212 [Multi-domain] Cd Length: 295 Bit Score: 39.46 E-value: 1.86e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  41 MFILISITYSQLvQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGGIEILILTAMAYDR 120
Cdd:cd15084  30 LVIVVSIKYKKL-RSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTMCEFEGFMVSLTGIVGLWSLAILAFER 108


                ....*...
gi 47577443 121 YVAICKPL 128
Cdd:cd15084 109 YLVICKPM 116

7tmA_alpha2C_AR

cd15323

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...

31-296

1.89e-03

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320446 [Multi-domain] Cd Length: 261 Bit Score: 39.15 E-value: 1.89e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  31 FCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGGIEI 110
Cdd:cd15323   9 FLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTSSI 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 111 LILTAMAYDRYVAICKPLHYTIIMSRGRCQAM------VTACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCdiypllt 184
Cdd:cd15323  89 VHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIivtvwlISAVISFPPLISMYRDPEGDVYPQCKLNDETWYIL------- 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 185 lactnTSRVGLLvVANTGMMGLVtflvlmwsysfilyTIRAYP-AESRRKALSTCSSHVT-VVILFFVPVLFIY-----I 257
Cdd:cd15323 162 -----SSCIGSF-FAPCLIMILV--------------YIRIYRvAKAREKRFTFVLAVVMgVFVVCWFPFFFSYslygiC 221

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 47577443 258 RPATTYPEdKVFALFYTI--LAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15323 222 REACEVPE-PLFKFFFWIgyCNSSLNPVIYTIFNQDFRRSF 261

7tmA_alpha1A_AR

cd15325

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

39-138

2.06e-03

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320448 [Multi-domain] Cd Length: 261 Bit Score: 39.11 E-value: 2.06e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  39 GNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGGIEILILTAMAY 118
Cdd:cd15325  17 GNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMSLCIISI 96

                        90       100
                ....*....|....*....|
gi 47577443 119 DRYVAICKPLHYTIIMSRGR 138
Cdd:cd15325  97 DRYIGVSYPLRYPSIMTERR 116

7tmA_NTSR-like

cd14979

neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...

28-156

2.44e-03

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320110 [Multi-domain] Cd Length: 300 Bit Score: 38.88 E-value: 2.44e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  28 LFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERN-IISYTSCMLQLFTMHFFG 106
Cdd:cd14979   6 IYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYPwAFGDGGCKLYYFLFEACT 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 47577443 107 GIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFF 156
Cdd:cd14979  86 YATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIP 135

7tmA_photoreceptors_insect

cd15079

insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...

25-146

2.87e-03

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320207 [Multi-domain] Cd Length: 292 Bit Score: 38.71 E-value: 2.87e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  25 CFPLFLFCyISILGGNMFILISITYSQLVQQPMYFFLNyLALSDLCYTSTvTPKFLSDLIIERNIISYTSCMLQLFTMHF 104
Cdd:cd15079   5 FIYIFLGI-VSLLGNGLVIYIFSTTKSLRTPSNMLVVN-LAISDFLMMIK-MPIFIYNSFYEGWALGPLGCQIYAFLGSL 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 47577443 105 FGGIEILILTAMAYDRYVAICKPLHYTiIMSRGRCQAMVTAC 146
Cdd:cd15079  82 SGIGSIWTNAAIAYDRYNVIVKPLNGN-PLTRGKALLLILFI 122

7tmA_Opsin_Gq_invertebrates

cd15337

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...

33-144

3.01e-03

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320459 [Multi-domain] Cd Length: 292 Bit Score: 38.84 E-value: 3.01e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  33 YISILG-----GNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVT-PKFLSDLIIERNIISYTSCMLQLFTMHFFG 106
Cdd:cd15337   6 YIAIVGilgviGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNGfPLKTISSFNKKWIWGKVACELYGFAGGIFG 85

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 47577443 107 GIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVT 144
Cdd:cd15337  86 FMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMII 123

7tmA_UII-R

cd14999

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...

39-128

3.10e-03

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.

Pssm-ID: 320130 [Multi-domain] Cd Length: 282 Bit Score: 38.58 E-value: 3.10e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  39 GNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVtPKFLSDLIIERNIISYTSCM----LQLFTMHffggIEILILT 114
Cdd:cd14999  16 GNVYTLVVMCLSMRPRASMYVYILNLALADLLYLLTI-PFYVSTYFLKKWYFGDVGCRllfsLDFLTMH----ASIFTLT 90

                        90
                ....*....|....
gi 47577443 115 AMAYDRYVAICKPL 128
Cdd:cd14999  91 VMSTERYLAVVKPL 104

7tmA_5-HT2C

cd15305

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...

28-145

3.67e-03

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341346 [Multi-domain] Cd Length: 275 Bit Score: 38.35 E-value: 3.67e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  28 LFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNI-ISYTSCMLQLFTMHFFG 106
Cdd:cd15305   6 LILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDYAWpLPRYLCPIWISLDVLFS 85

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 47577443 107 GIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTA 145
Cdd:cd15305  86 TASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAA 124

7tmA_tyramine_octopamine_R-like

cd15060

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...

39-295

3.68e-03

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320188 [Multi-domain] Cd Length: 260 Bit Score: 38.18 E-value: 3.68e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  39 GNMFILISI-TYSQL--VQQpmyFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGGIEILILTA 115
Cdd:cd15060  17 GNILVILSVfTYRPLriVQN---FFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCDILCCTASILNLCA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 116 MAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSffqnllaiSLPFCGHNEMDHYFCDIYPlltlaCTNTSRVGL 195
Cdd:cd15060  94 IALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALIS--------VPPLIGWNDWPENFTETTP-----CTLTEEKGY 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 196 LVVANTGmmglvTFLVLMWSYSFILYTI-RAYPAEsrRKALSTCSSHVTVVILFFVPVLFIY-IRP--ATTYPEDKV--F 269
Cdd:cd15060 161 VIYSSSG-----SFFIPLLIMTIVYVKIfIATSKE--RRAARTLGIIMGVFVVCWLPFFLMYvILPfcETCSPSAKVvnF 233

                       250       260
                ....*....|....*....|....*.
gi 47577443 270 ALFYTILAPMFNPLIYTLRNTEMKNA 295
Cdd:cd15060 234 ITWLGYVNSALNPVIYTIFNLDFRRA 259

7tmA_purinoceptor-like

cd14982

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...

64-251

3.71e-03

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341318 [Multi-domain] Cd Length: 283 Bit Score: 38.40 E-value: 3.71e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  64 LALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGGIEILILTAMAYDRYVAICKPLHYTIImsRGRCQAMv 143
Cdd:cd14982  42 LALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGLLFYINMYGSILFLTCISVDRYLAVVHPLKSRRL--RRKRYAV- 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 144 tACCAGAFIHSFFQNLLAISLPFCGHNEMDHYFCDIYPLLTLACTNTSRVGLLVVantgmMGLVTFLVLMWSYSFILYTI 223
Cdd:cd14982 119 -GVCAGVWILVLVASVPLLLLRSTIAKENNSTTCFEFLSEWLASAAPIVLIALVV-----GFLIPLLIILVCYSLIIRAL 192

                       170       180       190
                ....*....|....*....|....*....|...
gi 47577443 224 RAYPAES-----RRKALSTCSSHVTVVILFFVP 251
Cdd:cd14982 193 RRRSKQSqksvrKRKALRMILIVLAVFLVCFLP 225

7tm_GPCRs

cd14964

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...

25-257

4.73e-03

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410628 [Multi-domain] Cd Length: 267 Bit Score: 38.18 E-value: 4.73e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  25 CFPLFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHF 104
Cdd:cd14964   1 TTIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 105 FGGIEILILTAMAYDRYVAICKPLHYTIIMSRGRCQAMVTACCAGAFIHSFfqnllaisLPFCGHNEMDHYFCDIYpllt 184
Cdd:cd14964  81 ANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSI--------PPLVGKGAIPRYNTLTG---- 148

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 47577443 185 LACTNTSRVGLLVVANTGMMGLVTFLVLMwSYSFILYTIRAYPAESRRKALSTCSSHVTVVILFFVPVLFIYI 257
Cdd:cd14964 149 SCYLICTTIYLTWGFLLVSFLLPLVAFLV-IFSRIVLRLRRRVRAIRSAASLNTDKNLKATKSLLILVITFLL 220

7tmA_NPSR

cd15197

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...

33-148

4.94e-03

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).

Pssm-ID: 320325 [Multi-domain] Cd Length: 294 Bit Score: 38.17 E-value: 4.94e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  33 YISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCytsTVTPKFLSDlIIERNIISYTSCMLQLFTMHFFGGIEI-- 110
Cdd:cd15197  11 FVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLC---VGLINVLTD-IIWRITVEWRAGDFACKVIRYLQVVVTya 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 47577443 111 --LILTAMAYDRYVAICKPLHYtiimSRGRCQAMVTACCA 148
Cdd:cd15197  87 stYVLVALSIDRYDAICHPMNF----SQSGRQARVLICVA 122

7tmA_Opioid_R-like

cd14970

opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...

32-128

5.01e-03

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.

Pssm-ID: 320101 [Multi-domain] Cd Length: 282 Bit Score: 38.04 E-value: 5.01e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  32 CYISILGGNMFILISITYSQLVQQPMYFFLNyLALSDLCYTSTVtPKFLSDLIIERNIISYTSCMLQLFTMHFFGGIEIL 111
Cdd:cd14970  11 CVVGLTGNSLVIYVILRYSKMKTVTNIYILN-LAVADELFLLGL-PFLATSYLLGYWPFGEVMCKIVLSVDAYNMFTSIF 88

                        90
                ....*....|....*..
gi 47577443 112 ILTAMAYDRYVAICKPL 128
Cdd:cd14970  89 CLTVMSVDRYLAVVHPV 105

7tmA_5-HT1E

cd15335

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...

40-296

6.26e-03

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320457 [Multi-domain] Cd Length: 258 Bit Score: 37.60 E-value: 6.26e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  40 NMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGGIEILILTAMAYD 119
Cdd:cd15335  18 NSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVDMTCCTCSILHLCVIALD 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 120 RYVAICKPLHYTIIMSRGRCQAMV-TACCAGAFIHS---FFQNLLAISLPFCGHNEMDHYFCDIYplltlactntSRVGL 195
Cdd:cd15335  98 RYWAITDAIEYARKRTAKRAGLMIlTVWTISIFISIpplFWRNHHDANIPSQCIIQHDHVIYTIY----------STFGA 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443 196 LVVANTgmmglvtfLVLmwsysfILYTiRAYPAESR-RKALSTCSSHVTVVIL----FFVPVLFIYIRPATTYPEDKVFA 270
Cdd:cd15335 168 FYIPLT--------LIL------ILYY-RIYHAASReRKAARILGLILGAFILswlpFFIKELIVGLSVMTVSPEVADFL 232

                       250       260
                ....*....|....*....|....*.
gi 47577443 271 LFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15335 233 TWLGYVNSLVNPLLYTSFNEDFKLAF 258

7tmA_GPR19

cd15008

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...

28-145

6.61e-03

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320137 [Multi-domain] Cd Length: 275 Bit Score: 37.51 E-value: 6.61e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  28 LFLFCYISILGGNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDLIIERNIISYTSCMLQLFTMHFFGG 107
Cdd:cd15008   5 VFGVLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTPG 84

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 47577443 108 IEILILTAMAYDRYVAICKPLHYTIimSRGRCQAMVTA 145
Cdd:cd15008  85 VQIYVLLSICVDRFYTIVYPLSFKV--SREKAKKMIAA 120

7tmA_CCK-BR

cd15979

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...

37-128

7.27e-03

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320645 [Multi-domain] Cd Length: 275 Bit Score: 37.49 E-value: 7.27e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  37 LGGNMFILISITYSQLVQQPMYFFLNYLALSDL-----CYTSTVTPKFLSDLIIERNIisytsCMLQLFTMHFFGGIEIL 111
Cdd:cd15979  15 VFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLmlavfCMPFTLIPNLMGTFIFGEVI-----CKAVAYLMGVSVSVSTF 89

                        90
                ....*....|....*..
gi 47577443 112 ILTAMAYDRYVAICKPL 128
Cdd:cd15979  90 SLVAIAIERYSAICNPL 106

7tmA_ETH-R

cd14997

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...

29-129

8.34e-03

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320128 [Multi-domain] Cd Length: 294 Bit Score: 37.27 E-value: 8.34e-03

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47577443  29 FLFCYISILG--GNMFILISITYSQLVQQPMYFFLNYLALSDLCYTSTVTPKFLSDL-IIERNIISYTSCMLQLFTMHFF 105
Cdd:cd14997   5 VVYGVIFVVGvlGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETwAREPWLLGEFMCKLVPFVELTV 84

                        90       100
                ....*....|....*....|....
gi 47577443 106 GGIEILILTAMAYDRYVAICKPLH 129
Cdd:cd14997  85 AHASVLTILAISFERYYAICHPLQ 108

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01