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Conserved domains on  [gi|4507937|ref|NP_000371|]
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DNA repair protein complementing XP-A cells isoform 1 [Homo sapiens]

Protein Classification

rad14 family protein( domain architecture ID 11489407)

rad14 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
rad14 TIGR00598
DNA repair protein; All proteins in this family for which functions are known are used for the ...
 105-273 1.03e-86

DNA repair protein; All proteins in this family for which functions are known are used for the recognition of DNA damage as part of nucleotide excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


:

Pssm-ID: 273164  Cd Length: 172  Bit Score: 255.87  E-value: 1.03e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507937    105 CEECGKEFMDSYLMNHFDLPTCDNCRDADDKHKLITKTEAKQEYLLKDCDLEKREPPLKFIVKKNPHHSQWGDMKLYLKL 184
Cdd:TIGR00598   1 CEECGKIFMDSYLFDHFDCAVCDNCRDKDDKYKLLTKTEAKEEYLLKDCDLDKREPLLRRIVKKNPHNPRWGDMKLYLKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507937    185 QIVKRSLEVWGSQEALEEAKEVRQENREKMKQKKFDKKVKELRRAVRSSVW--KRETIVHQHEYGPEEN-LEDDMYRKTC 261
Cdd:TIGR00598  81 QVEKRALEVWGSEEALDEEKERREESKEEMKEKKFEKKLKELRRAVRSSEYtnKKEGRVHEHEFGPETNgVEEDTYRRTC 160

                         170
                  ....*....|..
gi 4507937    262 TMCGHELTYEKM 273
Cdd:TIGR00598 161 TTCGLEETYEKM 172
 
Name Accession Description Interval E-value
rad14 TIGR00598
DNA repair protein; All proteins in this family for which functions are known are used for the ...
 105-273 1.03e-86

DNA repair protein; All proteins in this family for which functions are known are used for the recognition of DNA damage as part of nucleotide excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273164  Cd Length: 172  Bit Score: 255.87  E-value: 1.03e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507937    105 CEECGKEFMDSYLMNHFDLPTCDNCRDADDKHKLITKTEAKQEYLLKDCDLEKREPPLKFIVKKNPHHSQWGDMKLYLKL 184
Cdd:TIGR00598   1 CEECGKIFMDSYLFDHFDCAVCDNCRDKDDKYKLLTKTEAKEEYLLKDCDLDKREPLLRRIVKKNPHNPRWGDMKLYLKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507937    185 QIVKRSLEVWGSQEALEEAKEVRQENREKMKQKKFDKKVKELRRAVRSSVW--KRETIVHQHEYGPEEN-LEDDMYRKTC 261
Cdd:TIGR00598  81 QVEKRALEVWGSEEALDEEKERREESKEEMKEKKFEKKLKELRRAVRSSEYtnKKEGRVHEHEFGPETNgVEEDTYRRTC 160

                         170
                  ....*....|..
gi 4507937    262 TMCGHELTYEKM 273
Cdd:TIGR00598 161 TTCGLEETYEKM 172
DBD_XPA cd21076
DNA-binding domain found in DNA repair protein complementing XP-A cells (XPA) and similar ...
 101-207 8.06e-75

DNA-binding domain found in DNA repair protein complementing XP-A cells (XPA) and similar proteins; XPA, also known as xeroderma pigmentosum group A-complementing protein (XPAC), is involved in DNA excision repair. It initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region.


Pssm-ID: 410962 [Multi-domain]  Cd Length: 107  Bit Score: 223.29  E-value: 8.06e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507937  101 DYVICEECGKEFMDSYLMNHFDLPTCDNCRDADDKHKLITKTEAKQEYLLKDCDLEKREPPLKFIVKKNPHHSQWGDMKL 180
Cdd:cd21076   1 DYLICEECGKEFMDSYLYNHFDLPVCDNCRDADGKHKLITKTEAKQEYLLKDCDLDKREPPLKFILKKNPHNSRWGDMKL 80

                        90       100
                ....*....|....*....|....*..
gi 4507937  181 YLKLQIVKRSLEVWGSQEALEEAKEVR 207
Cdd:cd21076  81 YLKLQVEKRALEVWGSEEALEEEKEKR 107
XPA_C pfam05181
XPA protein C-terminus;
135-186 2.86e-26

XPA protein C-terminus;


Pssm-ID: 461572  Cd Length: 51  Bit Score: 97.23  E-value: 2.86e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 4507937    135 KHKLITKTEAKQEYLLKDCDLEKREpPLKFIVKKNPHHSQWGDMKLYLKLQI 186
Cdd:pfam05181   1 KYSLITKTEAKEDYLLTDCDLKDRE-LLRFLKKPNPHNGTWGDMKLYLRLQV 51
RAD14 COG5145
DNA excision repair protein [DNA replication, recombination, and repair];
105-273 7.76e-21

DNA excision repair protein [DNA replication, recombination, and repair];


Pssm-ID: 227474  Cd Length: 292  Bit Score: 89.29  E-value: 7.76e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507937  105 CEECGKEFMDSYLMNHFDLPTCDNCRDA-DDKHKLITKTEAKQEYLLKDCDLeKREPPLKFIVKKNPHHSQWGDMKLYLK 183
Cdd:COG5145 119 CKECLQIELDDELEDTFGISVCRSCRHSmPDKYKLLTKTECKSDYLLTDPEL-KDQELFRRLQKPNPHKGTWSKMHLYLR 197

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507937  184 LQIVKRSLEVWGSQEALEEAKEVRQENREKMKQKKFDKKVKELRRAVRSSVWK----RETIVHQHEYGPE-ENLEDDMYR 258
Cdd:COG5145 198 EEVEQFAIKKWGSLEELDREKQRREKMKDDRKEKKLEKKIKELRRKTRTSNYSrmdvREKEKHVHVFDEFvDGPNEPGVI 277

                       170
                ....*....|....*
gi 4507937  259 KTCTMCGHELTYEKM 273
Cdd:COG5145 278 IQRCSCGLEVEQEEI 292
 
Name Accession Description Interval E-value
rad14 TIGR00598
DNA repair protein; All proteins in this family for which functions are known are used for the ...
 105-273 1.03e-86

DNA repair protein; All proteins in this family for which functions are known are used for the recognition of DNA damage as part of nucleotide excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273164  Cd Length: 172  Bit Score: 255.87  E-value: 1.03e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507937    105 CEECGKEFMDSYLMNHFDLPTCDNCRDADDKHKLITKTEAKQEYLLKDCDLEKREPPLKFIVKKNPHHSQWGDMKLYLKL 184
Cdd:TIGR00598   1 CEECGKIFMDSYLFDHFDCAVCDNCRDKDDKYKLLTKTEAKEEYLLKDCDLDKREPLLRRIVKKNPHNPRWGDMKLYLKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507937    185 QIVKRSLEVWGSQEALEEAKEVRQENREKMKQKKFDKKVKELRRAVRSSVW--KRETIVHQHEYGPEEN-LEDDMYRKTC 261
Cdd:TIGR00598  81 QVEKRALEVWGSEEALDEEKERREESKEEMKEKKFEKKLKELRRAVRSSEYtnKKEGRVHEHEFGPETNgVEEDTYRRTC 160

                         170
                  ....*....|..
gi 4507937    262 TMCGHELTYEKM 273
Cdd:TIGR00598 161 TTCGLEETYEKM 172
DBD_XPA cd21076
DNA-binding domain found in DNA repair protein complementing XP-A cells (XPA) and similar ...
 101-207 8.06e-75

DNA-binding domain found in DNA repair protein complementing XP-A cells (XPA) and similar proteins; XPA, also known as xeroderma pigmentosum group A-complementing protein (XPAC), is involved in DNA excision repair. It initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region.


Pssm-ID: 410962 [Multi-domain]  Cd Length: 107  Bit Score: 223.29  E-value: 8.06e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507937  101 DYVICEECGKEFMDSYLMNHFDLPTCDNCRDADDKHKLITKTEAKQEYLLKDCDLEKREPPLKFIVKKNPHHSQWGDMKL 180
Cdd:cd21076   1 DYLICEECGKEFMDSYLYNHFDLPVCDNCRDADGKHKLITKTEAKQEYLLKDCDLDKREPPLKFILKKNPHNSRWGDMKL 80

                        90       100
                ....*....|....*....|....*..
gi 4507937  181 YLKLQIVKRSLEVWGSQEALEEAKEVR 207
Cdd:cd21076  81 YLKLQVEKRALEVWGSEEALEEEKEKR 107
XPA_C pfam05181
XPA protein C-terminus;
135-186 2.86e-26

XPA protein C-terminus;


Pssm-ID: 461572  Cd Length: 51  Bit Score: 97.23  E-value: 2.86e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 4507937    135 KHKLITKTEAKQEYLLKDCDLEKREpPLKFIVKKNPHHSQWGDMKLYLKLQI 186
Cdd:pfam05181   1 KYSLITKTEAKEDYLLTDCDLKDRE-LLRFLKKPNPHNGTWGDMKLYLRLQV 51
DBD_Rad14 cd21077
DNA-binding domain found in yeast DNA repair protein Rad14 and similar proteins; Rad14 is ...
 104-207 9.09e-25

DNA-binding domain found in yeast DNA repair protein Rad14 and similar proteins; Rad14 is involved in nucleotide excision repair. It binds specifically to damaged DNA and is required for the incision step. Rad14 is a component of the nucleotide excision repair factor 1 (NEF1) complex consisting of Rad1, Rad10 and Rad14.


Pssm-ID: 410963 [Multi-domain]  Cd Length: 105  Bit Score: 95.16  E-value: 9.09e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507937  104 ICEECGKEFMDSYLMNHFDLPTCDNCRDA-DDKHKLITKTEAKQEYLLKDCDLEKREPpLKFIVKKNPHHSQWGDMKLYL 182
Cdd:cd21077   2 KCRECGSNEIDDVLHDVFGVSVCKACKEKhPEKYSLLTKTECKEDYLLTDPELNDEEL-LPHLEKPNPHKSTWSDMQLFL 80

                        90       100
                ....*....|....*....|....*
gi 4507937  183 KLQIVKRSLEVWGSQEALEEAKEVR 207
Cdd:cd21077  81 RCQVEAFALKKWGSPEALDEEFERR 105
DBD_XPA-like cd21075
DNA-binding domain found in DNA repair protein complementing XP-A cells (XPA), yeast DNA ...
 137-205 2.56e-21

DNA-binding domain found in DNA repair protein complementing XP-A cells (XPA), yeast DNA repair protein RAD14 and similar proteins; The family includes DNA repair protein complementing XP-A cells (XPA), yeast DNA repair protein RAD14, zinc transporter 9 (ZNT9) and similar proteins. XPA, also known as xeroderma pigmentosum group A-complementing protein (XPAC), is involved in DNA excision repair. It initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Rad14 is involved in nucleotide excision repair. It binds specifically to damaged DNA and is required for the incision step. Rad14 is a component of the nucleotide excision repair factor 1 (NEF1) complex consisting of Rad1, Rad10 and Rad14. ZNT9, also known as solute carrier family 30 member 9 (SLC30A9), may act as a zinc transporter involved in intracellular zinc homeostasis and may also play a role as nuclear receptor coactivator. The model corresponds to the DNA-binding domain found in XPA and Rad14. It consists of a conserved N-terminal zinc-binding subdomain and a C-terminal alpha/beta fold subdomain. ZNT9 contains only C-terminal alpha/beta fold subdomain but lacks of N-terminal zinc-binding subdomain.


Pssm-ID: 410961  Cd Length: 67  Bit Score: 84.94  E-value: 2.56e-21
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4507937  137 KLITKTEAKQEYLLKDCDLEKreppLKFIVKKNPHHSQWGDMKLYLKLQIVKRSLEVWGSQEALEEAKE 205
Cdd:cd21075   1 RLITKTDAKKEYRLTDKDLAG----LPYEEKPNPHGPSAAPMKLYLEREVERLAWRKHGGPEGLEAALE 65
RAD14 COG5145
DNA excision repair protein [DNA replication, recombination, and repair];
105-273 7.76e-21

DNA excision repair protein [DNA replication, recombination, and repair];


Pssm-ID: 227474  Cd Length: 292  Bit Score: 89.29  E-value: 7.76e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507937  105 CEECGKEFMDSYLMNHFDLPTCDNCRDA-DDKHKLITKTEAKQEYLLKDCDLeKREPPLKFIVKKNPHHSQWGDMKLYLK 183
Cdd:COG5145 119 CKECLQIELDDELEDTFGISVCRSCRHSmPDKYKLLTKTECKSDYLLTDPEL-KDQELFRRLQKPNPHKGTWSKMHLYLR 197

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507937  184 LQIVKRSLEVWGSQEALEEAKEVRQENREKMKQKKFDKKVKELRRAVRSSVWK----RETIVHQHEYGPE-ENLEDDMYR 258
Cdd:COG5145 198 EEVEQFAIKKWGSLEELDREKQRREKMKDDRKEKKLEKKIKELRRKTRTSNYSrmdvREKEKHVHVFDEFvDGPNEPGVI 277

                       170
                ....*....|....*
gi 4507937  259 KTCTMCGHELTYEKM 273
Cdd:COG5145 278 IQRCSCGLEVEQEEI 292
XPA_N pfam01286
XPA protein N-terminal;
104-133 3.60e-13

XPA protein N-terminal;


Pssm-ID: 460148  Cd Length: 32  Bit Score: 62.17  E-value: 3.60e-13
                          10        20        30
                  ....*....|....*....|....*....|
gi 4507937    104 ICEECGKEFMDSYLMNHFDLPTCDNCRDAD 133
Cdd:pfam01286   3 KCLECGKPFLDSYLLDNFDYPVCDKCRDKE 32
NTD_ZNT9 cd21078
N-terminal domain found in zinc transporter 9 (ZNT9) and similar proteins; ZNT9, also known as ...
 137-212 4.86e-13

N-terminal domain found in zinc transporter 9 (ZNT9) and similar proteins; ZNT9, also known as solute carrier family 30 member 9 (SLC30A9), may act as a zinc transporter involved in intracellular zinc homeostasis and may also play a role as nuclear receptor coactivator.


Pssm-ID: 410964  Cd Length: 89  Bit Score: 63.37  E-value: 4.86e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4507937  137 KLITKTEAKQEYLLKDCDLEKreppLKFIVKKNPHHSQwGDMKLYLKLQIVKRSLEVWGSQEALEEAKEVRQENRE 212
Cdd:cd21078   3 NYITAVRAMNEYLLKPSDLEG----LRKIKRRSPYDDE-PPITVYLRSDVEAKAIEKWGSLEALEKERKKRKEIEE 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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