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Conserved domains on  [gi|4557467|ref|NP_000073|]
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DNA excision repair protein ERCC-8 isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
14-361 2.59e-35

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.88  E-value: 2.59e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467   14 DPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPvEGRYMLSGGSDGVIVLYDLEnssrqsyyTCKAVCSIGRd 93
Cdd:COG2319  91 RLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLA--------TGKLLRTLTG- 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467   94 hpdvHRYSVETVQWYPhDTGMFTSSSFDKTLKVWDTNTLQTADVFnfeetvySHHMSPV-----STKHCLVAVGTRGPKV 168
Cdd:COG2319 161 ----HSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTL-------TGHTGAVrsvafSPDGKLLASGSADGTV 228

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467  169 QLCDLKSGSCSHILQGHRQEILAVSWSPrYDYILATASADSRVKLWDVRRASgCLITLdqhngkksqavesanTAHNGKV 248
Cdd:COG2319 229 RLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGE-LLRTL---------------TGHSGGV 291

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467  249 NGLCFTSDGLHLLTVGTDNRMRLWNSSNGE--NTLvnygkvcnnskKGLKFTVSCgcsseFVFVPYGSTIA--------- 317
Cdd:COG2319 292 NSVAFSPDGKLLASGSDDGTVRLWDLATGKllRTL-----------TGHTGAVRS-----VAFSPDGKTLAsgsddgtvr 355

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....
gi 4557467  318 VYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361
Cdd:COG2319 356 LWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
14-361 2.59e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.88  E-value: 2.59e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467   14 DPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPvEGRYMLSGGSDGVIVLYDLEnssrqsyyTCKAVCSIGRd 93
Cdd:COG2319  91 RLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLA--------TGKLLRTLTG- 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467   94 hpdvHRYSVETVQWYPhDTGMFTSSSFDKTLKVWDTNTLQTADVFnfeetvySHHMSPV-----STKHCLVAVGTRGPKV 168
Cdd:COG2319 161 ----HSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTL-------TGHTGAVrsvafSPDGKLLASGSADGTV 228

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467  169 QLCDLKSGSCSHILQGHRQEILAVSWSPrYDYILATASADSRVKLWDVRRASgCLITLdqhngkksqavesanTAHNGKV 248
Cdd:COG2319 229 RLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGE-LLRTL---------------TGHSGGV 291

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467  249 NGLCFTSDGLHLLTVGTDNRMRLWNSSNGE--NTLvnygkvcnnskKGLKFTVSCgcsseFVFVPYGSTIA--------- 317
Cdd:COG2319 292 NSVAFSPDGKLLASGSDDGTVRLWDLATGKllRTL-----------TGHTGAVRS-----VAFSPDGKTLAsgsddgtvr 355

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....
gi 4557467  318 VYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361
Cdd:COG2319 356 LWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 40-361 2.71e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 131.30  E-value: 2.71e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467   40 RIHGGGINTLDIEPVeGRYMLSGGSDGVIVLYDLENSSRQSYYTckavcsigrdhpdVHRYSVETVQWYPHDTGMFtSSS 119
Cdd:cd00200   6 KGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLK-------------GHTGPVRDVAASADGTYLA-SGS 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467  120 FDKTLKVWDTNTLQTADVFN-FEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPrY 198
Cdd:cd00200  71 SDKTIRLWDLETGECVRTLTgHTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-D 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467  199 DYILATASADSRVKLWDVRRASgCLITLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE 278
Cdd:cd00200 147 GTFVASSSQDGTIKLWDLRTGK-CVATL---------------TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467  279 NTLVNYGKvcNNSKKGLKFTVS----CGCSSEfvfvpygSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSR 354
Cdd:cd00200 211 CLGTLRGH--ENGVNSVAFSPDgyllASGSED-------GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA 281


                ....*..
gi 4557467  355 DCNILAW 361
Cdd:cd00200 282 DGTIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 175-215 2.22e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 2.22e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 4557467     175 SGSCSHILQGHRQEILAVSWSPRYDYiLATASADSRVKLWD 215
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
176-215 5.09e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 5.09e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 4557467    176 GSCSHILQGHRQEILAVSWSPRYDYiLATASADSRVKLWD 215
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 172-282 1.07e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 47.64  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467   172 DLKSGSCshILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV---RRA---------------------SGCLITLD 227
Cdd:PTZ00420 113 EIKDPQC--ILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIeneKRAfqinmpkklsslkwnikgnllSGTCVGKH 190

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4557467   228 QH-NGKKSQAVESANTAHNGKVNGLCFTSDGL-----HLLTVG-TDNRMR---LWNSSNGENTLV 282
Cdd:PTZ00420 191 MHiIDPRKQEIASSFHIHDGGKNTKNIWIDGLggddnYILSTGfSKNNMRemkLWDLKNTTSALV 255
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
14-361 2.59e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.88  E-value: 2.59e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467   14 DPLRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPvEGRYMLSGGSDGVIVLYDLEnssrqsyyTCKAVCSIGRd 93
Cdd:COG2319  91 RLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLA--------TGKLLRTLTG- 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467   94 hpdvHRYSVETVQWYPhDTGMFTSSSFDKTLKVWDTNTLQTADVFnfeetvySHHMSPV-----STKHCLVAVGTRGPKV 168
Cdd:COG2319 161 ----HSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTL-------TGHTGAVrsvafSPDGKLLASGSADGTV 228

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467  169 QLCDLKSGSCSHILQGHRQEILAVSWSPrYDYILATASADSRVKLWDVRRASgCLITLdqhngkksqavesanTAHNGKV 248
Cdd:COG2319 229 RLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGE-LLRTL---------------TGHSGGV 291

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467  249 NGLCFTSDGLHLLTVGTDNRMRLWNSSNGE--NTLvnygkvcnnskKGLKFTVSCgcsseFVFVPYGSTIA--------- 317
Cdd:COG2319 292 NSVAFSPDGKLLASGSDDGTVRLWDLATGKllRTL-----------TGHTGAVRS-----VAFSPDGKTLAsgsddgtvr 355

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....
gi 4557467  318 VYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361
Cdd:COG2319 356 LWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 40-361 2.71e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 131.30  E-value: 2.71e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467   40 RIHGGGINTLDIEPVeGRYMLSGGSDGVIVLYDLENSSRQSYYTckavcsigrdhpdVHRYSVETVQWYPHDTGMFtSSS 119
Cdd:cd00200   6 KGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLK-------------GHTGPVRDVAASADGTYLA-SGS 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467  120 FDKTLKVWDTNTLQTADVFN-FEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPrY 198
Cdd:cd00200  71 SDKTIRLWDLETGECVRTLTgHTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-D 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467  199 DYILATASADSRVKLWDVRRASgCLITLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSNGE 278
Cdd:cd00200 147 GTFVASSSQDGTIKLWDLRTGK-CVATL---------------TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467  279 NTLVNYGKvcNNSKKGLKFTVS----CGCSSEfvfvpygSTIAVYTVYSGEQITMLKGHYKTVDCCVFQSNFQELYSGSR 354
Cdd:cd00200 211 CLGTLRGH--ENGVNSVAFSPDgyllASGSED-------GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA 281


                ....*..
gi 4557467  355 DCNILAW 361
Cdd:cd00200 282 DGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
16-361 6.86e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.73  E-value: 6.86e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467   16 LRLRRAESTRRVLGLELNKDRDVERIHGGGINTLDIEPvEGRYMLSGGSDGVIVLYDLENSSRQSyytckavcsigrdHP 95
Cdd:COG2319  51 LAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLR-------------TL 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467   96 DVHRYSVETVQWYPhDTGMFTSSSFDKTLKVWDTNTLQTADVFN-FEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLK 174
Cdd:COG2319 117 TGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDGK---LLASGSDDGTVRLWDLA 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467  175 SGSCSHILQGHRQEILAVSWSP--RYdyiLATASADSRVKLWDVRRASgCLITLdqhngkksqavesanTAHNGKVNGLC 252
Cdd:COG2319 193 TGKLLRTLTGHTGAVRSVAFSPdgKL---LASGSADGTVRLWDLATGK-LLRTL---------------TGHSGSVRSVA 253

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467  253 FTSDGLHLLTVGTDNRMRLWNSSNGEntlvnygkvCNNSKKGLKFTVSCgcsseFVFVPYGSTIA---------VYTVYS 323
Cdd:COG2319 254 FSPDGRLLASGSADGTVRLWDLATGE---------LLRTLTGHSGGVNS-----VAFSPDGKLLAsgsddgtvrLWDLAT 319

                       330       340       350
                ....*....|....*....|....*....|....*...
gi 4557467  324 GEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361
Cdd:COG2319 320 GKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
42-273 9.32e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.86  E-value: 9.32e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467   42 HGGGINTLDIEPvEGRYMLSGGSDGVIVLYDLEnssrqsyyTCKAVCSIGRdhpdvHRYSVETVQWYPhDTGMFTSSSFD 121
Cdd:COG2319 203 HTGAVRSVAFSP-DGKLLASGSADGTVRLWDLA--------TGKLLRTLTG-----HSGSVRSVAFSP-DGRLLASGSAD 267

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467  122 KTLKVWDTNTLQTADVFN-FEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPrYDY 200
Cdd:COG2319 268 GTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGK---LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGK 343

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4557467  201 ILATASADSRVKLWDVRrASGCLITLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273
Cdd:COG2319 344 TLASGSDDGTVRLWDLA-TGELLRTL---------------TGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 42-273 2.90e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 109.35  E-value: 2.90e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467   42 HGGGINTLDIEPvEGRYMLSGGSDGVIVLYDLENssrqsyYTCKAVCsigRDHPDvhrySVETVQWyPHDTGMFTSSSFD 121
Cdd:cd00200  92 HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVET------GKCLTTL---RGHTD----WVNSVAF-SPDGTFVASSSQD 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467  122 KTLKVWDTNTLQTADVFN-FEETVYSHHMSPVSTKHClvaVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRyDY 200
Cdd:cd00200 157 GTIKLWDLRTGKCVATLTgHTGEVNSVAFSPDGEKLL---SSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GY 232

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4557467  201 ILATASADSRVKLWDVRRASgCLITLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273
Cdd:cd00200 233 LLASGSEDGTIRVWDLRTGE-CVQTL---------------SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
98-361 9.47e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.83  E-value: 9.47e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467   98 HRYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQTADVFNFEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGS 177
Cdd:COG2319  35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR---LLASASADGTVRLWDLATGL 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467  178 CSHILQGHRQEILAVSWSPryD-YILATASADSRVKLWDVrrASG-CLITLdqhngkksqavesanTAHNGKVNGLCFTS 255
Cdd:COG2319 112 LLRTLTGHTGAVRSVAFSP--DgKTLASGSADGTVRLWDL--ATGkLLRTL---------------TGHSGAVTSVAFSP 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467  256 DGLHLLTVGTDNRMRLWNSSNGE--NTLvnygkvcnnskKGLKFTVSCgcsseFVFVPYGSTIA---------VYTVYSG 324
Cdd:COG2319 173 DGKLLASGSDDGTVRLWDLATGKllRTL-----------TGHTGAVRS-----VAFSPDGKLLAsgsadgtvrLWDLATG 236

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 4557467  325 EQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361
Cdd:COG2319 237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
42-217 1.75e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.28  E-value: 1.75e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467   42 HGGGINTLDIEPvEGRYMLSGGSDGVIVLYDLENSSRQSYYTckavcsigrdhpdVHRYSVETVQWYPhDTGMFTSSSFD 121
Cdd:COG2319 245 HSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLT-------------GHSGGVNSVAFSP-DGKLLASGSDD 309

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467  122 KTLKVWDTNTLQTADVFN-FEETVYSHHMSPVSTkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDY 200
Cdd:COG2319 310 GTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGK---TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRT 386

                       170
                ....*....|....*..
gi 4557467  201 iLATASADSRVKLWDVR 217
Cdd:COG2319 387 -LASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 178-361 1.73e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.30  E-value: 1.73e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467  178 CSHILQGHRQEILAVSWSPRYDYiLATASADSRVKLWDVrrasgclitldqhngkKSQAVESANTAHNGKVNGLCFTSDG 257
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDL----------------ETGELLRTLKGHTGPVRDVAASADG 63

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467  258 LHLLTVGTDNRMRLWNSSNGEntlvnygkvCNNSKKGLKFTVSCgcsseFVFVPYGS---------TIAVYTVYSGEQIT 328
Cdd:cd00200  64 TYLASGSSDKTIRLWDLETGE---------CVRTLTGHTSYVSS-----VAFSPDGRilssssrdkTIKVWDVETGKCLT 129

                       170       180       190
                ....*....|....*....|....*....|...
gi 4557467  329 MLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361
Cdd:cd00200 130 TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 175-215 2.22e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 2.22e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 4557467     175 SGSCSHILQGHRQEILAVSWSPRYDYiLATASADSRVKLWD 215
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
176-215 5.09e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 5.09e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 4557467    176 GSCSHILQGHRQEILAVSWSPRYDYiLATASADSRVKLWD 215
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 172-282 1.07e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 47.64  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467   172 DLKSGSCshILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV---RRA---------------------SGCLITLD 227
Cdd:PTZ00420 113 EIKDPQC--ILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIeneKRAfqinmpkklsslkwnikgnllSGTCVGKH 190

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4557467   228 QH-NGKKSQAVESANTAHNGKVNGLCFTSDGL-----HLLTVG-TDNRMR---LWNSSNGENTLV 282
Cdd:PTZ00420 191 MHiIDPRKQEIASSFHIHDGGKNTKNIWIDGLggddnYILSTGfSKNNMRemkLWDLKNTTSALV 255
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 82-275 1.28e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.39  E-value: 1.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467    82 YTCKAVCSIGRD--HPDVH---RYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQ-TADVFNFEETVYSHHMSpvSTK 155
Cdd:PLN00181 510 FECESIIKDGRDihYPVVElasRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQlVTEMKEHEKRVWSIDYS--SAD 587

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467   156 HCLVAVGTRGPKVQLCDLKSGSCSHILQGhRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLITLdqhngkksq 235
Cdd:PLN00181 588 PTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTM--------- 657

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 4557467   236 avesanTAHNGKVNGLCFTsDGLHLLTVGTDNRMRLWNSS 275
Cdd:PLN00181 658 ------IGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLS 690
WD40 COG2319
WD40 repeat [General function prediction only];
42-131 6.19e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.90  E-value: 6.19e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467   42 HGGGINTLDIEPvEGRYMLSGGSDGVIVLYDLENSSRQSYYTckavcsigrdhpdVHRYSVETVQWYPhDTGMFTSSSFD 121
Cdd:COG2319 329 HTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLT-------------GHTGAVTSVAFSP-DGRTLASGSAD 393

                        90
                ....*....|
gi 4557467  122 KTLKVWDTNT 131
Cdd:COG2319 394 GTVRLWDLAT 403
PTZ00421 PTZ00421
coronin; Provisional
 173-277 1.76e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 43.34  E-value: 1.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467   173 LKSGSCSHI--LQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRasgclitldqhnGKKSQAVESantaHNGKVNG 250
Cdd:PTZ00421 110 LTQNISDPIvhLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER------------GKAVEVIKC----HSDQITS 173

                         90       100
                 ....*....|....*....|....*..
gi 4557467   251 LCFTSDGLHLLTVGTDNRMRLWNSSNG 277
Cdd:PTZ00421 174 LEWNLDGSLLCTTSKDKKLNIIDPRDG 200
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 242-273 3.78e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 3.78e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 4557467     242 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 192-278 1.50e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.64  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557467    192 VSWSPRYDyILATASADSRVklwDVRRASGclitldqhngkksQAVESANT-AHNGKVNGLCFTSDGlHLLTVGT-DNRM 269
Cdd:pfam12894   1 MSWCPTMD-LIALATEDGEL---LLHRLNW-------------QRVWTLSPdKEDLEVTSLAWRPDG-KLLAVGYsDGTV 62


                  ....*....
gi 4557467    270 RLWNSSNGE 278
Cdd:pfam12894  63 RLLDAENGK 71
WD40 pfam00400
WD domain, G-beta repeat;
242-273 3.12e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 3.12e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 4557467    242 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 323-361 4.80e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 4.80e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 4557467     323 SGEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
324-361 5.70e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 5.70e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 4557467    324 GEQITMLKGHYKTVDCCVFQSNFQELYSGSRDCNILAW 361
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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