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Conserved domains on  [gi|1014087614|gb|KYS36569|]
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magnesium transporter CorA [Escherichia coli]

Protein Classification

magnesium transporter CorA( domain architecture ID 10793529)

magnesium transporter CorA mediates both influx and efflux of magnesium, and may also transport nickel and cobalt

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11085 PRK11085
magnesium/cobalt transporter CorA;
1-316 0e+00

magnesium/cobalt transporter CorA;


:

Pssm-ID: 182951  Cd Length: 316  Bit Score: 642.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614   1 MLSAFQLENNRLTRLEVEESQPLVNAVWIDLVEPDDDERLRVQSELGQSLATRPELEDIEASARFFEDDDGLHIHSFFFF 80
Cdd:PRK11085    1 MLSAFQLENNRLTRLEVEESQPLVDAVWIDLVEPDDDERLRVQSELGQSLATRPELEDIEASARFFEDEDGLHIHSFFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  81 EDAEDHAGNSTVAFTIRDGRLFTLRERELPAFRLYRMRARSQSMVDGNAYELLLDLFETKIEQLADEIENIYSDLEQLSR 160
Cdd:PRK11085   81 EDAEDHAGNSTVAFTIRDGRLFTLRERELPAFRLYRMRARSQTLVDGNAYELLLDLFETKIEQLADEIENIYSDLEKLSR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 161 VIMEGHQGDEYDEALSTLAELEDIGWKVRLCLMDTQRALNFLVRKARLPGGQLEQAREILRDIESLLPHNESLFQKVNFL 240
Cdd:PRK11085  161 VIMEGHQGDEYDEALSTLAELEDIGWKVRLCLMDTQRALNFLVRKARLPGGQLEQAREILRDIESLLPHNESLFQKVNFL 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1014087614 241 MQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIIFMILAGLAPYLYFKRKNWL 316
Cdd:PRK11085  241 MQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIILMILAGLAPYLYFKRKNWL 316
 
Name Accession Description Interval E-value
PRK11085 PRK11085
magnesium/cobalt transporter CorA;
1-316 0e+00

magnesium/cobalt transporter CorA;


Pssm-ID: 182951  Cd Length: 316  Bit Score: 642.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614   1 MLSAFQLENNRLTRLEVEESQPLVNAVWIDLVEPDDDERLRVQSELGQSLATRPELEDIEASARFFEDDDGLHIHSFFFF 80
Cdd:PRK11085    1 MLSAFQLENNRLTRLEVEESQPLVDAVWIDLVEPDDDERLRVQSELGQSLATRPELEDIEASARFFEDEDGLHIHSFFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  81 EDAEDHAGNSTVAFTIRDGRLFTLRERELPAFRLYRMRARSQSMVDGNAYELLLDLFETKIEQLADEIENIYSDLEQLSR 160
Cdd:PRK11085   81 EDAEDHAGNSTVAFTIRDGRLFTLRERELPAFRLYRMRARSQTLVDGNAYELLLDLFETKIEQLADEIENIYSDLEKLSR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 161 VIMEGHQGDEYDEALSTLAELEDIGWKVRLCLMDTQRALNFLVRKARLPGGQLEQAREILRDIESLLPHNESLFQKVNFL 240
Cdd:PRK11085  161 VIMEGHQGDEYDEALSTLAELEDIGWKVRLCLMDTQRALNFLVRKARLPGGQLEQAREILRDIESLLPHNESLFQKVNFL 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1014087614 241 MQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIIFMILAGLAPYLYFKRKNWL 316
Cdd:PRK11085  241 MQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIILMILAGLAPYLYFKRKNWL 316
EcCorA-like_1 cd12835
Escherichia coli Mg2+ transporter CorA_like subgroup; A bacterial subgroup of the Escherichia ...
 28-316 1.68e-175

Escherichia coli Mg2+ transporter CorA_like subgroup; A bacterial subgroup of the Escherichia coli CorA-Salmonella typhimurium ZntB_like (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subgroup includes the Mg2+ transporters Escherichia coli CorA and Salmonella typhimurium CorA (which can also transport Co2+, and Ni2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213369  Cd Length: 287  Bit Score: 486.76  E-value: 1.68e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  28 WIDLVEPDDDERLRVQSELGQSLATRPELEDIEASARFFEDDDGLHIHSFFFFEDaEDHAGNSTVAFTIRDGRLFTLRER 107
Cdd:cd12835     1 WIDLIAPDDEEREWLEQLLGQELPDLEDLEEIEASARFYVDEDGLHIHSLFLQDS-EGRARNVTVAFTLRDDRLITLREE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 108 ELPAFRLYRMRARSQSMVDGNAYELLLDLFETKIEQLADEIENIYSDLEQLSRVIMEGHQGDeYDEALSTLAELEDIGWK 187
Cdd:cd12835    80 ELPVFRLLRLRARRGPGEVSDPKDLLLDLFEQKVEYLADIIEDIYRDLERVSREVLEENDED-LEEALGRLARQEDLNGK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 188 VRLCLMDTQRALNFLVRKARLPGGQLEQAREILRDIESLLPHNESLFQKVNFLMQAAMGFINIEQNRIIKIFSVVSVVFL 267
Cdd:cd12835   159 IRLCLMDTQRALSFLLRTRRLSDEQLEDAREILRDIESLLPHTQFLFDKINFLMDAAMGFINIEQNKIIKIFSVAAVVFL 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1014087614 268 PPTLVASSYGMNFEFMPELKWSFGYPGAIIFMILAGLAPYLYFKRKNWL 316
Cdd:cd12835   239 PPTLIASIYGMNFDFMPELDWKFGYPMAIGLMILSAIAPYLYFKRKGWL 287
corA TIGR00383
magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp ...
 2-316 2.66e-132

magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp Genomics 1998;3(3):151-69 discusses this family and suggests that some members may have functions other than Mg2+ transport. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273048 [Multi-domain]  Cd Length: 318  Bit Score: 378.65  E-value: 2.66e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614   2 LSAFQLENNRLTRLE--VEESQPLVNAVWIDLVEPDDDERLrvqSELGQSLATRP-ELEDIEASA---RFFEDDDGLHIH 75
Cdd:TIGR00383   1 ITAIAIEKSRLIKIPffEEFSQELNTVLWIDLIEPTDEERL---AKLGQFFAIHPlALEDILNSPqrpKVEEDEDHLFII 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  76 SFFFFEDAEDHAGNSTVAFTIRDGRLFTLRERELPAFRLYRMRARS-QSMVDGNAYELLLDLFETKIEQLADEIENIYSD 154
Cdd:TIGR00383  78 SFFLNEDEDDTFETEQVSFILGKNLLFTIHERELPAFDSIRERIRTsQKVFEKGADYLLYDIFDAIIDSYFPLLENIEDE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 155 LEQLSRVIMEGHQGDEYDEALSTLAELEdigwKVRLCLMDTQRALNFLVRKARLPGgQLEQAREILRD----IESLLPHN 230
Cdd:TIGR00383 158 LEELEDEIISGPTSTLMDEILSLRTELL----ALRRSLWPLRDVLNFLLRKTHLPI-QTEEVREYLRDiydhILSLLEMI 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 231 ESLFQKVNFLMQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIIFMILAGLAPYLYF 310
Cdd:TIGR00383 233 ETYRELLSSLMDLYLSLVNNKMNEIMKILTVVSTIFIPLTFIAGIYGMNFKFMPELNWKYGYPAVLIVMAVIALGPLIYF 312


                  ....*.
gi 1014087614 311 KRKNWL 316
Cdd:TIGR00383 313 RRKGWL 318
CorA COG0598
Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];
16-316 2.31e-81

Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];


Pssm-ID: 440363 [Multi-domain]  Cd Length: 305  Bit Score: 248.59  E-value: 2.31e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  16 EVEESQPLVNAVWIDLVEPDDDERLRVQSELGQSLATRPELEDIEASARFFEDDDGLHIHS-FFFFEDAEDHAGNSTVAF 94
Cdd:COG0598     5 ALEELLDPEGFVWIDLDGPTDEELEWLAEEFGLHPLALEDALDIEQRPKLEEYDDYLFIVLrTLNYNEEEEELETGPLSI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  95 TIRDGRLFTLRERELPAFRLYRMRARS-QSMVDGNAYELLLDLFETKIEQLADEIENIYSDLEQLSRVIMEGHQgdeyDE 173
Cdd:COG0598    85 FLGPNFLITVRERPLDAFDDVRERLERgPGLLPRGPDYLLYALLDAIVDRYFPVLEELEDELDELEDELFESPD----NE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 174 ALSTLAELEDIGWKVRLCLMDTQRALNFLVR--KARLPGGQLEQAREILRDIESLLPHNESLFQKVNFLMQAAMGFINIE 251
Cdd:COG0598   161 LLRRLYRLRRELVRLRRALAPLREVLSRLLRgeSPLISEEDREYLRDVYDHLERLLEMVDSLRERLSGLLDAYLSLISNR 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1014087614 252 QNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIIFMILAGLAPYLYFKRKNWL 316
Cdd:COG0598   241 QNEIMKVLTIIAAIFLPPTFIAGIYGMNFEGMPELDWPYGYPIVLGLMLLIAVLLYLYFKRKGWL 305
CorA pfam01544
CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx ...
 27-312 2.58e-54

CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx system of Salmonella typhimurium and Escherichia coli. CorA is virtually ubiquitous in the Bacteria and Archaea. There are also eukaryotic relatives of this protein. The family includes the MRS2 protein from yeast that is thought to be an RNA splicing protein. However its membership of this family suggests that its effect on splicing is due to altered magnesium levels in the cell.


Pssm-ID: 460246 [Multi-domain]  Cd Length: 292  Bit Score: 179.05  E-value: 2.58e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  27 VWIDLVEPDDDERLRVQSELGQSLATRPELEDIEASARFFEDDDGLHIHSFFFFED-AEDHAGNSTVAFTIRDGRLFTLR 105
Cdd:pfam01544   5 VWLDLDSPTEAELEWLARTLGLDPLALEDLLDPEERPRVEDYDDYFLLVLPGVNLDdSEEADELVTVSILLGDNFLITVR 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 106 ERELPAFRLYRMRARSQSMVDGNAYELLLDLFETKIEQLADEIENIYSDLEQLSRVIMEghqgDEYDEALSTLAELEDIG 185
Cdd:pfam01544  85 HEPLPALDEVRKRLTLLGGGPLDPGDLLYRLLDEIVDRFLELLEKLEDELDELEDELED----ETNNELLRELAALRRSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 186 WKVRLCLMDTQRALNFLVRKAR---LPGGQLEQAREILRDIESLLPHNESLFQKVNFLMQAAMGFINIEQNRIIKIFSVV 262
Cdd:pfam01544 161 VYLRRSLLPQRDVLNRLLRREDdplLDDEQKEYLRDLLDRLERLLEDLDALRERLRSLQDEYSSLLSERTNRVMKVLTVV 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1014087614 263 SVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIIF--MILAGLAPYLYFKR 312
Cdd:pfam01544 241 TAIFLPLTLITGIYGMNFGGLPELEWSYGYPFVLILglMILLAILLLFYFRR 292
 
Name Accession Description Interval E-value
PRK11085 PRK11085
magnesium/cobalt transporter CorA;
1-316 0e+00

magnesium/cobalt transporter CorA;


Pssm-ID: 182951  Cd Length: 316  Bit Score: 642.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614   1 MLSAFQLENNRLTRLEVEESQPLVNAVWIDLVEPDDDERLRVQSELGQSLATRPELEDIEASARFFEDDDGLHIHSFFFF 80
Cdd:PRK11085    1 MLSAFQLENNRLTRLEVEESQPLVDAVWIDLVEPDDDERLRVQSELGQSLATRPELEDIEASARFFEDEDGLHIHSFFFF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  81 EDAEDHAGNSTVAFTIRDGRLFTLRERELPAFRLYRMRARSQSMVDGNAYELLLDLFETKIEQLADEIENIYSDLEQLSR 160
Cdd:PRK11085   81 EDAEDHAGNSTVAFTIRDGRLFTLRERELPAFRLYRMRARSQTLVDGNAYELLLDLFETKIEQLADEIENIYSDLEKLSR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 161 VIMEGHQGDEYDEALSTLAELEDIGWKVRLCLMDTQRALNFLVRKARLPGGQLEQAREILRDIESLLPHNESLFQKVNFL 240
Cdd:PRK11085  161 VIMEGHQGDEYDEALSTLAELEDIGWKVRLCLMDTQRALNFLVRKARLPGGQLEQAREILRDIESLLPHNESLFQKVNFL 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1014087614 241 MQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIIFMILAGLAPYLYFKRKNWL 316
Cdd:PRK11085  241 MQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIILMILAGLAPYLYFKRKNWL 316
EcCorA-like_1 cd12835
Escherichia coli Mg2+ transporter CorA_like subgroup; A bacterial subgroup of the Escherichia ...
 28-316 1.68e-175

Escherichia coli Mg2+ transporter CorA_like subgroup; A bacterial subgroup of the Escherichia coli CorA-Salmonella typhimurium ZntB_like (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subgroup includes the Mg2+ transporters Escherichia coli CorA and Salmonella typhimurium CorA (which can also transport Co2+, and Ni2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213369  Cd Length: 287  Bit Score: 486.76  E-value: 1.68e-175
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  28 WIDLVEPDDDERLRVQSELGQSLATRPELEDIEASARFFEDDDGLHIHSFFFFEDaEDHAGNSTVAFTIRDGRLFTLRER 107
Cdd:cd12835     1 WIDLIAPDDEEREWLEQLLGQELPDLEDLEEIEASARFYVDEDGLHIHSLFLQDS-EGRARNVTVAFTLRDDRLITLREE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 108 ELPAFRLYRMRARSQSMVDGNAYELLLDLFETKIEQLADEIENIYSDLEQLSRVIMEGHQGDeYDEALSTLAELEDIGWK 187
Cdd:cd12835    80 ELPVFRLLRLRARRGPGEVSDPKDLLLDLFEQKVEYLADIIEDIYRDLERVSREVLEENDED-LEEALGRLARQEDLNGK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 188 VRLCLMDTQRALNFLVRKARLPGGQLEQAREILRDIESLLPHNESLFQKVNFLMQAAMGFINIEQNRIIKIFSVVSVVFL 267
Cdd:cd12835   159 IRLCLMDTQRALSFLLRTRRLSDEQLEDAREILRDIESLLPHTQFLFDKINFLMDAAMGFINIEQNKIIKIFSVAAVVFL 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1014087614 268 PPTLVASSYGMNFEFMPELKWSFGYPGAIIFMILAGLAPYLYFKRKNWL 316
Cdd:cd12835   239 PPTLIASIYGMNFDFMPELDWKFGYPMAIGLMILSAIAPYLYFKRKGWL 287
EcCorA-like cd12825
Escherichia coli Mg2+ transporter CorA_like subfamily; A bacterial subfamily of the ...
 28-316 5.66e-138

Escherichia coli Mg2+ transporter CorA_like subfamily; A bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB_like(EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporters Escherichia coli, Salmonella typhimurium, and Helicobacter pylori CorAs (which can also transport Co2+, and Ni2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213359 [Multi-domain]  Cd Length: 287  Bit Score: 392.06  E-value: 5.66e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  28 WIDLVEPDDDERLRVQSELGQSLATRPELEDIEASARFFEDDDGLHIHSFFFFEDAEDHAGNSTVAFTIRDGRLFTLRER 107
Cdd:cd12825     1 WIDLINPTEEELATLSSEYGFILPPREHLEDIEISSRYWEDDSQLFITLSFPNQTKEDTIEEEPVTFIIKGNILFTIRYR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 108 ELPAFRLYRMRARSQSMVDGNAYELLLDLFETKIEQLADEIENIYSDLEQLSRVIMEGHQgdEYDEALSTLAELEDIGWK 187
Cdd:cd12825    81 DLPAFDIFPKRAFSQRKFFNSGEELFLFLFEVIVDYLADILENISKKIKQLSREILEEKQ--FSEEDLDALTKLNENNIT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 188 VRLCLMDTQRALNFLVRKARLPGGQLEQAREILRDIESLLPHNESLFQKVNFLMQAAMGFINIEQNRIIKIFSVVSVVFL 267
Cdd:cd12825   159 LRESLIEKQRIITLLLKSPRENSDTKEKLKIELRDLSSLLDHTTFNFDKLDDLKNNILGKIELEQNKIIKIFTVVTVCFL 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1014087614 268 PPTLVASSYGMNFEFMPELKWSFGYPGAIIFMILAGLAPYLYFKRKNWL 316
Cdd:cd12825   239 PPTLIASIYGMNFKNMPELKWSYGYPFALILMILSTILPLLYFKRKGWL 287
corA TIGR00383
magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp ...
 2-316 2.66e-132

magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp Genomics 1998;3(3):151-69 discusses this family and suggests that some members may have functions other than Mg2+ transport. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273048 [Multi-domain]  Cd Length: 318  Bit Score: 378.65  E-value: 2.66e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614   2 LSAFQLENNRLTRLE--VEESQPLVNAVWIDLVEPDDDERLrvqSELGQSLATRP-ELEDIEASA---RFFEDDDGLHIH 75
Cdd:TIGR00383   1 ITAIAIEKSRLIKIPffEEFSQELNTVLWIDLIEPTDEERL---AKLGQFFAIHPlALEDILNSPqrpKVEEDEDHLFII 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  76 SFFFFEDAEDHAGNSTVAFTIRDGRLFTLRERELPAFRLYRMRARS-QSMVDGNAYELLLDLFETKIEQLADEIENIYSD 154
Cdd:TIGR00383  78 SFFLNEDEDDTFETEQVSFILGKNLLFTIHERELPAFDSIRERIRTsQKVFEKGADYLLYDIFDAIIDSYFPLLENIEDE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 155 LEQLSRVIMEGHQGDEYDEALSTLAELEdigwKVRLCLMDTQRALNFLVRKARLPGgQLEQAREILRD----IESLLPHN 230
Cdd:TIGR00383 158 LEELEDEIISGPTSTLMDEILSLRTELL----ALRRSLWPLRDVLNFLLRKTHLPI-QTEEVREYLRDiydhILSLLEMI 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 231 ESLFQKVNFLMQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIIFMILAGLAPYLYF 310
Cdd:TIGR00383 233 ETYRELLSSLMDLYLSLVNNKMNEIMKILTVVSTIFIPLTFIAGIYGMNFKFMPELNWKYGYPAVLIVMAVIALGPLIYF 312


                  ....*.
gi 1014087614 311 KRKNWL 316
Cdd:TIGR00383 313 RRKGWL 318
MIT_CorA-like cd11744
metal ion transporter CorA-like divalent cation transporter superfamily; This superfamily of ...
 28-315 8.08e-132

metal ion transporter CorA-like divalent cation transporter superfamily; This superfamily of essential membrane proteins is involved in transporting divalent cations (uptake or efflux) across membranes. They are found in most bacteria and archaea, and in some eukaryotes. It is a functionally diverse group which includes the Mg2+ transporters of Escherichia coli and Salmonella typhimurium CorAs (which can also transport Co2+, and Ni2+ ), the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and the Zn2+ transporter Salmonella typhimurium ZntB, which mediates the efflux of Zn2+ (and Cd2+). It includes five Saccharomyces cerevisiae members: i) two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, ii) two mitochondrial inner membrane Mg2+ transporters: Mfm1p/Lpe10p, and Mrs2p, and iii) and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. It also includes a family of Arabidopsis thaliana members (AtMGTs), some of which are localized to distinct tissues, and not all of which can transport Mg2+. Thermotoga maritima CorA and Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, Mrs2p, and Alr1p. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213354 [Multi-domain]  Cd Length: 286  Bit Score: 376.54  E-value: 8.08e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  28 WIDLVEPDDDERLRVQSELGqslATRPELEDIEA---SARFFEDDDGLHIHSFFFFEDAE-DHAGNSTVAFTIRDGRLFT 103
Cdd:cd11744     1 WIHCERLHDDDIRRVLEDNL---HVPRALEDILLaesRPSFHPLDDNFMIILRGFNMDENaSPEDMLSVRILYFQGALIS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 104 LRERELPAFRLYRMRARSQSMVDGNAYELLLDLFETKIEQLADEIENIYSDLEQLSRVIMEGHqgdeYDEALSTLAELED 183
Cdd:cd11744    78 TREIPSRAFMEIRQRLREHSKGPKSAASLLNQLIEGLNGKIDLYLETIEETLNELDVNDEEGH----YDESTYNHIALQK 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 184 IGWKVRLCLMDTQRALNFLVRKAR-LPGGQLEQAREILRDIESLLPHNESLFQKVNFLMQAAMGFINIEQNRIIKIFSVV 262
Cdd:cd11744   154 ALISIRRFIRPQQYALRDLIRSESeLVTSRPHQYRFAHNNITRINETIEFYLGEVALLQDEIKHNRDEKTNKNSKLFTLV 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1014087614 263 SVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIIFMILAGLAPYLYFKRKNW 315
Cdd:cd11744   234 ATIFLPTTFLAGLYGMNFEGMPGVESSMAFTWFCIALIVAFGLEWLLFKRKGF 286
EcCorA-like_u1 cd12837
uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; A ...
 27-316 1.83e-97

uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; A uncharacterized subgroup of the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. The EcCorA_ZntB-like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA_ZntB-like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213371 [Multi-domain]  Cd Length: 298  Bit Score: 289.43  E-value: 1.83e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  27 VWIDLVEPDDDERLRVQSELGQSLATRPELEDIEASARFFEDDDGLHIHSFFFFEDAEDHAGNSTVAFTIRDGRLFTLRE 106
Cdd:cd12837     1 VWIDLLNPTPEEEAAVEALLGIAIPTREEMSEIEASSRLYREGGALYMTAPLLSRADTDDPELSPVTFVLTPERLVTVRY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 107 RELPAFRLYRMRARSQSMVDGNAYELLLDLFETKIEQLADEIENIYSDLEQLSRVIMEGHQGDE------YDEALSTLAE 180
Cdd:cd12837    81 ADPRAFDTFAARAARQPSGCASGEDVLLGLLEAIVDRLADVLERVGADLDRLSRRIFRSSAKRRrrasrdLRSVLRRIGR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 181 LEDIGWKVRLCLMDTQRALNFLVR--KARLPGGQLEQAREILRDIESLLPHNESLFQKVNFLMQAAMGFINIEQNRIIKI 258
Cdd:cd12837   161 AGDLLSKIRESLLSLGRLLSFLSAnaADWLSKELRARLKTLQRDVASLSEHATFLSNKIQFLLDATLGLINIEQNNIIKI 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1014087614 259 FSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIIFMILAGLAPYLYFKRKNWL 316
Cdd:cd12837   241 FSVASVVFLPPTLIASIYGMNFKHMPELDWPFGYPLALGLMVLSAVLPLLWFKRRGWL 298
HpCorA-like cd12836
Mg2+ transporter Helicobacter pylori CorA-like subgroup; A bacterial subgroup of the ...
 27-316 6.08e-87

Mg2+ transporter Helicobacter pylori CorA-like subgroup; A bacterial subgroup of the Escherichia coli CorA-Salmonella typhimurium ZntB_like (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subgroup includes the Mg2+ transporter Helicobacter pylori CorAs (which can also transport Co2+, and Ni2+); CorA plays an important role in the viability of this pathogen. Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB (members of the EcCorA_ZntB-like family) form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213370 [Multi-domain]  Cd Length: 288  Bit Score: 262.20  E-value: 6.08e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  27 VWIDLVEPDDDERLRVQSELGQSLATRPELEDIEASARFFEDDDGLHIHSFFFFEDaEDHAGNSTVAFTIRDGRLFTLRE 106
Cdd:cd12836     2 LWIDLINPTEEEIKTVEQYFNIEFPTKQESEEIESSSRYWEDEDSITINSNFLVPD-DDGYHNEPVSFILKDNILFTIRY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 107 RELPAFR--LYRMRARSQSMVDGnaYELLLDLFETKIEQLADEIENIYSDLEQLSRVIMegHQGDEYDEALSTLAELEDI 184
Cdd:cd12836    81 GELRTFSetSKKLRANPKKFQTG--YDIFSSILEIRIDYDADLLENISKEISKLRKKLF--ADEDLDEELLEKISRLQEL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 185 GWKVRLCLMDTQRALNFLVRKARLPGGQLEQAREILRDIESLLPHNESLFQKVNFLMQAAMGFINIEQNRIIKIFSVVSV 264
Cdd:cd12836   157 NMTIRENLIDKQRVLSSLLKSEKFPEDLKENLRIMIKDINSLIEHTTFNFERLDYLQNTFLGLINIEQNKIIKIFTVATV 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1014087614 265 VFLPPTLVASSYGMNFEFMPELKWSFGYPGAIIFMILAGLAPYLYFKRKNWL 316
Cdd:cd12836   237 IFMPPTLIASIYGMNFKFMPELDWKYGYPFALLLMVISSILPLLYFKKKKWL 288
CorA COG0598
Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];
16-316 2.31e-81

Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];


Pssm-ID: 440363 [Multi-domain]  Cd Length: 305  Bit Score: 248.59  E-value: 2.31e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  16 EVEESQPLVNAVWIDLVEPDDDERLRVQSELGQSLATRPELEDIEASARFFEDDDGLHIHS-FFFFEDAEDHAGNSTVAF 94
Cdd:COG0598     5 ALEELLDPEGFVWIDLDGPTDEELEWLAEEFGLHPLALEDALDIEQRPKLEEYDDYLFIVLrTLNYNEEEEELETGPLSI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  95 TIRDGRLFTLRERELPAFRLYRMRARS-QSMVDGNAYELLLDLFETKIEQLADEIENIYSDLEQLSRVIMEGHQgdeyDE 173
Cdd:COG0598    85 FLGPNFLITVRERPLDAFDDVRERLERgPGLLPRGPDYLLYALLDAIVDRYFPVLEELEDELDELEDELFESPD----NE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 174 ALSTLAELEDIGWKVRLCLMDTQRALNFLVR--KARLPGGQLEQAREILRDIESLLPHNESLFQKVNFLMQAAMGFINIE 251
Cdd:COG0598   161 LLRRLYRLRRELVRLRRALAPLREVLSRLLRgeSPLISEEDREYLRDVYDHLERLLEMVDSLRERLSGLLDAYLSLISNR 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1014087614 252 QNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIIFMILAGLAPYLYFKRKNWL 316
Cdd:COG0598   241 QNEIMKVLTIIAAIFLPPTFIAGIYGMNFEGMPELDWPYGYPIVLGLMLLIAVLLYLYFKRKGWL 305
EcCorA_ZntB-like cd12821
Escherichia coli CorA-Salmonella typhimurium ZntB_like family; A family of the MIT superfamily ...
 28-315 3.76e-72

Escherichia coli CorA-Salmonella typhimurium ZntB_like family; A family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this family are found in all three kingdoms of life. It is a functionally diverse family, including the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs (which can also transport Co2+, and Ni2+ ), and the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). It also includes two Saccharomyces cerevisiae members: the inner membrane Mg2+ transporters Mfm1p/Lpe10p, and Mrs2p, and a family of Arabidopsis thaliana members (AtMGTs) some of which are localized to distinct tissues, and not all of which can transport Mg2+. Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213355 [Multi-domain]  Cd Length: 285  Bit Score: 224.50  E-value: 3.76e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  28 WIDLVEPDDDERlRVQSELGQSLaTRPELEDIEASARF----FEDDDGLHIHSFFFFEDAEdhagNSTVAFTIRDGRLFT 103
Cdd:cd12821     1 WYDIDEPDDEIR-RLLEELESSH-LPNDLRDILLGVSFprfeEVSGSGIYIQLRKPQKDAD----TASFHFLITRDRLIT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 104 LRERELPAFRLYRMRARSQSM-VDGNAYELLLDLFETKIEQLADEIENIYSDLEQLSRVIMEGHqgdeYDEALSTLAELE 182
Cdd:cd12821    75 VRLDELPALDELRQDLRSGQMkSAKSAAELLFVLLGAIIKALLTGIDQFEEKLEELEWDLLEGN----NAIKLDRILELR 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 183 DIGWKVRLCLMDTQRALNFLVRKAR--LPGGQLEQAREILRDIESLLPHNESLFQKVNFLMQAAMGFINIEQNRIIKIFS 260
Cdd:cd12821   151 RELLRLTNLIEPQQEVLMALQEAFAelLFSEDEEELRRTLDRIERLLQLIEEYEQELDTLQDIEEVVSSHRGNEIMKTLT 230

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1014087614 261 VVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIIFMILAGLAPYLYFKRKNW 315
Cdd:cd12821   231 VVTTVFLPLTLIGGLWGMNFKNMPELEWKYGYLFVLGLIILSTAGLYLYLRRKGW 285
CorA pfam01544
CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx ...
 27-312 2.58e-54

CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx system of Salmonella typhimurium and Escherichia coli. CorA is virtually ubiquitous in the Bacteria and Archaea. There are also eukaryotic relatives of this protein. The family includes the MRS2 protein from yeast that is thought to be an RNA splicing protein. However its membership of this family suggests that its effect on splicing is due to altered magnesium levels in the cell.


Pssm-ID: 460246 [Multi-domain]  Cd Length: 292  Bit Score: 179.05  E-value: 2.58e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  27 VWIDLVEPDDDERLRVQSELGQSLATRPELEDIEASARFFEDDDGLHIHSFFFFED-AEDHAGNSTVAFTIRDGRLFTLR 105
Cdd:pfam01544   5 VWLDLDSPTEAELEWLARTLGLDPLALEDLLDPEERPRVEDYDDYFLLVLPGVNLDdSEEADELVTVSILLGDNFLITVR 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 106 ERELPAFRLYRMRARSQSMVDGNAYELLLDLFETKIEQLADEIENIYSDLEQLSRVIMEghqgDEYDEALSTLAELEDIG 185
Cdd:pfam01544  85 HEPLPALDEVRKRLTLLGGGPLDPGDLLYRLLDEIVDRFLELLEKLEDELDELEDELED----ETNNELLRELAALRRSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 186 WKVRLCLMDTQRALNFLVRKAR---LPGGQLEQAREILRDIESLLPHNESLFQKVNFLMQAAMGFINIEQNRIIKIFSVV 262
Cdd:pfam01544 161 VYLRRSLLPQRDVLNRLLRREDdplLDDEQKEYLRDLLDRLERLLEDLDALRERLRSLQDEYSSLLSERTNRVMKVLTVV 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1014087614 263 SVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIIF--MILAGLAPYLYFKR 312
Cdd:pfam01544 241 TAIFLPLTLITGIYGMNFGGLPELEWSYGYPFVLILglMILLAILLLFYFRR 292
MtCorA-like cd12830
Mycobacterium tuberculosis CorA-like subfamily; This bacterial subfamily belongs to the ...
 27-316 2.50e-31

Mycobacterium tuberculosis CorA-like subfamily; This bacterial subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporter Mycobacterium tuberculosis CorA (which also transports Co2+). Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213364 [Multi-domain]  Cd Length: 292  Bit Score: 118.78  E-value: 2.50e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  27 VWIDLVEPDDDERLRVQSELG-QSLAT--------RPELEDIE-------ASARFFEDDDGLHIHSFFFFedaedhAGnS 90
Cdd:cd12830     3 VWVGLHEPDAEELAAVAEEFGlHELAVedavhahqRPKLERYGdslflvlRTARYVDHTEEVETGETHVF------VG-P 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  91 TVAFTIRDGR---LFTLRER-----EL----PAFRLYRMRARsqsMVDGnaYELLLDLFETKIEQL---------ADEIE 149
Cdd:cd12830    76 DFVVTVRHGAagpLARVRARleadpELlalgPDAVLYAILDF---IVDG--YLPVAEELEDDVDELeeevfspdrRDDIE 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 150 NIYsdleQLSRVIMEGHqgdeydEALSTLAEledigwkvrlclmdtqrALNFLVRKARLPGGqlEQAREILRDI------ 223
Cdd:cd12830   151 RIY----RLKREVLEFR------RAVDPLVE-----------------VLRRLARGHEPLIP--KELRPYFRDVadhllr 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 224 --ESLLPHNESLfqkvNFLMQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIIFMIL 301
Cdd:cd12830   202 vaDRVDSLRELL----SSALQANLALVSVQQNEDMRKISAWAAILAVPTAIAGIYGMNFDHMPELHWTYGYPLVLGLMVA 277

                         330
                  ....*....|....*
gi 1014087614 302 AGLAPYLYFKRKNWL 316
Cdd:cd12830   278 VCLGLYRRFRRNGWL 292
TmCorA-like cd12822
Thermotoga maritima CorA-like family; This family belongs to the MIT superfamily of essential ...
 28-316 2.21e-27

Thermotoga maritima CorA-like family; This family belongs to the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the Thermotoga maritima CorA_like family are found in all three kingdoms of life. It is a functionally diverse family, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes three Saccharomyces cerevisiae members: two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213356 [Multi-domain]  Cd Length: 289  Bit Score: 108.04  E-value: 2.21e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  28 WIDLVEPDDDERLRVQSELG-QSLAtrpeLEDIEASA---RFFEDDDglhiHSFFFF-----EDAEDHAGNSTVAFTIRD 98
Cdd:cd12822     1 WIDLEGPTEEELQLLAEEFGfHPLA----IEDALNERqrpKIEEYDD----YLFLVLralryDEEELELETSELSIFLGK 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  99 GRLFTLRERELPAFRLYRMRARSQSMVDGN-AYELLLDLFETKIEQLADEIENIYSDLEQLSRVIMEGHQGDEYDEAL-- 175
Cdd:cd12822    73 NFLVTVHEGPLRLIDEVIERLLSDPKLLPKgPDFLLYAILDAIVDSYFPILDELEDRLDELEDEILEEPRREVLRELFal 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 176 -STLAELedigwkvRLCLMDTQRALNFLVRkaRLPGGQLEQAREILRD----IESLLPHNESLFQKVNFLMQAAMGFINI 250
Cdd:cd12822   153 rRELLRL-------RRILSPQREVLNRLLR--RENELISEELRPYFRDvydhLERLAELLDSYRDLLSSLLDAYLSLQSN 223

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1014087614 251 EQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIIFMILAGLAPYLYFKRKNWL 316
Cdd:cd12822   224 RTNEVMKVLTIITTIFLPLTFITGIYGMNFEYMPELHWPYGYFIVLGIMLLIAGGLLWWFRRKKWL 289
TmCorA-like_1 cd12828
Thermotoga maritima CorA_like subfamily; This subfamily belongs to the Thermotoga maritima ...
 27-316 7.20e-23

Thermotoga maritima CorA_like subfamily; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this subfamily are found in all three kingdoms of life. It is functionally diverse subfamily, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes Methanosarcina mazei CorA which may be involved in transport of copper and/or other divalent metal ions. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213362 [Multi-domain]  Cd Length: 294  Bit Score: 95.96  E-value: 7.20e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  27 VWIDLVEPDDDERLRvqsELGQ-----SLAtrpeLEDI---EASARFFEDDDGLHI--HSFFFfEDAEDHAGNSTVAFTI 96
Cdd:cd12828     3 TWINVDGLHDIELIE---KLGErfglhPLV----LEDIlntGQRPKVEEYDDYLFIvlKMLYY-DEDTGELESEQVSLIL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  97 RDGRLFTLRERELPAFRLYRMRARS------QSMVDGNAYELL---LDLFETKIEQLADEIEniysDLEQlsRVIMEGHQ 167
Cdd:cd12828    75 GKNYVISFQERPGDVFDPVRERLRNgkgrirKKGADYLAYALLdaiVDNYFPVLEKLGDRIE----DLEE--ELLENPTP 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 168 GdeydealsTLAELEDIgwkvrlclmdtQRALNFLvRKARLP----GGQL---------EQAREILRD--------IESL 226
Cdd:cd12828   149 E--------TLERIHKL-----------KRELLFL-RRSIWPlrevINRLlrgesplisEETRPYLRDvydhtiqvIDTI 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 227 lphnESLFQKVNFLMQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIIFMILAGLAP 306
Cdd:cd12828   209 ----ETYRDMLSGLLDLYLSSVSNRMNEVMKVLTIISTIFIPLTFIAGIYGMNFEYMPELEWKYGYPAVLGVMLLIALGM 284

                         330
                  ....*....|
gi 1014087614 307 YLYFKRKNWL 316
Cdd:cd12828   285 LLYFKRKKWL 294
TmCorA-like_u3 cd12832
Uncharacterized subfamily of the Thermotoga maritima CorA-like family; This subfamily belongs ...
 28-316 1.88e-22

Uncharacterized subfamily of the Thermotoga maritima CorA-like family; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the TmCorA-like family are found in all three kingdoms of life. It is a functionally diverse family which includes the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and three Saccharomyces cerevisiae proteins: two located in the plasma membrane: the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213366 [Multi-domain]  Cd Length: 287  Bit Score: 94.59  E-value: 1.88e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  28 WIDLVEPDDDERLRVQSELGQSLATRPELEDIEASARFfEDDDGLHihsFFFF----EDAEDHAGNST-----VAFTIRD 98
Cdd:cd12832     1 WIDVVAPTEEDLEDLARRYNLHETSLKDCLDPDHLPKY-EEVDGVT---FIILrvytDKKRENADTIQelttkIAIFVVD 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  99 GRLFTLRERELPAFRLYRMRARSQSMVDGNAYELLLDL-------FETKIEQLADEIENIysdlEqlSRVIMEGHQGDey 171
Cdd:cd12832    77 KFVITIHRTDLEFIANLKEKWLSGMHKCESPTELLLRIvkdalktYEAPLEKLSEELDKY----E--EEVFLKKRKGS-- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 172 dealsTLAELEDIGWKVRLClmdtQRALNF---LVRKARLPGGQLEQAREILRDIESLLPHNESLFQKVNFLMQAamgFI 248
Cdd:cd12832   149 -----LLKRLYHLKRKASVI----KRVLNLtqdVIDKIDTPLKSDPYTQDLRDLLIKLLSLYDELHENATNLLSL---YI 216

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1014087614 249 NIEQNR---IIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIIFMILAGLAPYLYFKRKNWL 316
Cdd:cd12832   217 SLSSQRtneVMRVLTIFSVFFLPLTFIAGVYGMNFKYMPELHWKYGYPATLLVMIVIVVGIYFWFKRKGWL 287
TmCorA-like_u2 cd12831
Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; This ...
 253-316 1.49e-21

Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the TmCorA-like family are found in all three kingdoms of life. It is a functionally diverse family which includes the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and three Saccharomyces cerevisiae proteins: two located in the plasma membrane: the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213365 [Multi-domain]  Cd Length: 287  Bit Score: 92.23  E-value: 1.49e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1014087614 253 NRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIIFMILAGLAPYLYFKRKNWL 316
Cdd:cd12831   224 NSIMMTLTIISTIFMPLTFIAGIYGMNFEYMPELKWHYGYFVVLGIMLLIAIGMILWFKKKGWF 287
EcCorA_ZntB-like_u1 cd12826
uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB ...
 248-316 3.05e-21

uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; A uncharacterized subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB (EcCorA-ZntB_like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. The EcCorA-ZntB_like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA-ZntB_like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213360  Cd Length: 281  Bit Score: 91.09  E-value: 3.05e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1014087614 248 INIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIIFMILAGLAPYLYFKRKNWL 316
Cdd:cd12826   213 IDIRQNRIMKILTVVTTIFLPLTLITGWYGMNFTNMPELHWKYGYPVVIILSILIVVIEIIYFKKKKWL 281
EcCorA_ZntB-like_u2 cd12827
uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB ...
 28-316 7.18e-12

uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; A uncharacterized subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB (EcCorA-ZntB_like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes.The EcCorA-ZntB-like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA-ZntB-like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213361 [Multi-domain]  Cd Length: 289  Bit Score: 64.83  E-value: 7.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  28 WIDLVEPDDDERLRVQSELGQSLATRPELEDIEASARFFEDDDGLHIHSFFFFEDAEDHAGNST----VAFTIRDGRLFT 103
Cdd:cd12827     1 WINVVNPTEEEIEQLAEKYGIPEDFLTYALDEEERSRIEYDDDTDYLLIILDVPVEEEEDDDEYetipLGIILTKDRLIT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 104 LRERELPAFRLYRMRaRSQSMVDGNAYELLLDLFE----------TKIEQLADEIEN---------------------IY 152
Cdd:cd12827    81 ICNHETDLLDDFLEG-RVKNFDTSSKTRFLLQILYriatsylkylRQINKERDELEQelrkstknkelfqlldlekslVY 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 153 ------SD---LEQLSRviMEGHQGDEYDEALstlaeLEDIgwkvrlcLMDTQRALnflvrkarlpggqlEQArEILRDI 223
Cdd:cd12827   160 fstslkSNeivLEKLKR--SRSLKLDEEDKEL-----LEDV-------IIENKQAI--------------EMA-EIYSDI 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 224 esllphneslfqkVNFLMQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNfEFMPELKWSFGYPGAIIFMILAG 303
Cdd:cd12827   211 -------------LSGLMDAFASVISNNLNNVMKFLTSITIVLTIPTIITGFYGMN-VPLPFADSPYAFWIILLISLLLS 276

                         330
                  ....*....|...
gi 1014087614 304 LAPYLYFKRKNWL 316
Cdd:cd12827   277 VIVALILRRKKYF 289
Alr1p-like cd12829
Saccharomyces cerevisiae Alr1p-like subfamily; This eukaryotic subfamily belongs to the ...
 28-313 9.73e-10

Saccharomyces cerevisiae Alr1p-like subfamily; This eukaryotic subfamily belongs to the Thermotoga maritima CorA (TmCorA)-family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes three Saccharomyces cerevisiae members: two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213363 [Multi-domain]  Cd Length: 305  Bit Score: 58.43  E-value: 9.73e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  28 WIDLVEPDDDERLRVQSELGQSLATrpeLEDIEASarffEDDDGLHIHSFFFF----------EDAEDHAGNSTVAFTIR 97
Cdd:cd12829     1 WLDVQSPTDDDMRAIGKLFPIHPLT---LEDILSQ----DTREKVELFPNYYFisfraiesdsELDENVLEPVNVYIVVF 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  98 DGRLFTLRERELPAFRlyRMRARSQSMVDG---NAYELLLDLFETKIEQLADEIENIYSD---LEQLSRVIMEGHQGDey 171
Cdd:cd12829    74 REGILTFHFKPLDHIE--RVRKRIRLLSDShllSSDWVLYALLDSIVDSFFPLVDSIEKEvdsIDELVLLISSSDQSD-- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 172 dealsTLAELEDIGWKV---RLCLMDTQRALNFLvRKARLPGGQLEQAREI---LRDIESllpHNESLFQKVNF----LM 241
Cdd:cd12829   150 -----LLRRIGDLRRRVtslLRLLFAKSDVLKQL-LKRLMKKTFVSPDSEVaiyLGDVQD---HILTLLQKLNHyedlLS 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 242 QAAMGF---INIEQNR-------IIKIFSVVSVVFLPPTLVASSYGMN----FEFMPELKWSFGYpGAIIFMILAGLAPY 307
Cdd:cd12829   221 RSHSNYlaqLSLEMSQesngtdkAMLRLTVIATIFLPLQLITGLFGMNvkvpGQDIESLYWFFGI-VIVAIMVLVAIVVV 299


                  ....*.
gi 1014087614 308 LYFKRK 313
Cdd:cd12829   300 FLVRRW 305
ZntB_u1 cd12834
Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like ...
 78-313 1.54e-08

Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; The MIT superfamily of essential membrane proteins is involved in transporting divalent cations (uptake or efflux) across membranes. The ZntB-like subfamily includes the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN which occur in proteins belonging to this subfamily, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213368 [Multi-domain]  Cd Length: 290  Bit Score: 54.90  E-value: 1.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  78 FFFEDAEDHAGNSTVAFTIRDGRLFTLRERELPAFRLYRMRARSQSMVDGNAyelllDLFETKIEQLADEIENIYSDL-E 156
Cdd:cd12834    55 LERDFAEASTDVGTLRFAVTPRLLITARRQPLRSVDRLRQAVERGLRFRSPA-----DLLEHLLREQADTLSRIVRELtD 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 157 QLSRV---IMEGHQGDEYDE---ALSTLAELEdigwkvRLcLMDTQRALNFLVRKAR--LPGGQLEQAREILRDIESLLP 228
Cdd:cd12834   130 ELDRIedrLLSGRLRRERRElgaLRRRLVRLH------RL-LAPEPAALFRLLRRPPdwLPDADLETLRRLTERLDALDR 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 229 HNESLFQKVNFLMQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMP--ELKWSFGYpgAIIFMILAGLAP 306
Cdd:cd12834   203 DLVALQERARLLQEEIAARLAEQTNRSLYILSVVTALLLPPTLVTGLFGMNTGGLPlaEGPHGFWI--AVALALLAAGLA 280


                  ....*..
gi 1014087614 307 YLYFKRK 313
Cdd:cd12834   281 YLLLRRL 287
ZntB-like_1 cd12833
Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; A bacterial subgroup belonging to ...
 98-316 3.41e-05

Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; A bacterial subgroup belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subgroup includes the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, which occur in proteins belonging to this subfamily, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213367 [Multi-domain]  Cd Length: 290  Bit Score: 44.79  E-value: 3.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  98 DGRLFTLRERelpafRLYRMRARSQSMVDGNAYELLLDLFETKIEQLADEIENIYSDLEQL-----SRVIMEGHQGDEYD 172
Cdd:cd12833    75 PGRIISTRRR-----RLLAVDDIREALEAGKGPKSPGDFLAALAERLTDRMEDVIDELEDRldeleERVLEEEDEELRGE 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 173 -------------------EALSTLAeLEDIGWkvrlcLMDTQRAlnflvrkaRLpggqLEQAREILRDIESLlphnESL 233
Cdd:cd12833   150 laelrrqaialrrylapqrDALERLA-REDLPW-----LSDDDRL--------RL----REAADRLTRYIEDL----DAI 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 234 FQKVNFLMQAAMGFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIIFMILAGLAPYLYFKRK 313
Cdd:cd12833   208 RERAAVLQEELTNRRAEQMNRRMYVLSIVAAIFLPLGFLTGLLGINVGGIPGAENPWAFWIFCGLLVVLAVGLLLLFRRK 287


                  ...
gi 1014087614 314 NWL 316
Cdd:cd12833   288 KWL 290
ZntB-like cd12824
Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; A bacterial subfamily belonging ...
 29-313 4.74e-05

Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; A bacterial subfamily belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, which occur in proteins belonging to this subfamily, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213358 [Multi-domain]  Cd Length: 290  Bit Score: 44.43  E-value: 4.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614  29 IDLVEPDDDERLRVQSELGQslATRPELEDIEASARFFEDDDG-LHIHSFFFFEDAEDHAGNSTVAFTIRDGRLFTLRER 107
Cdd:cd12824     7 CDRADPAIRSWLEDNTHLPE--ATVDHLLAPVRFPHFEPVDDGfLLSLRGIRMDEAASPSDMADLRILIGQGAAVTVRSG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 108 ELPAFRLYRmrarsQSMVDGNAYELLLDLFETKIEQLADEIENIYSDLEQLSrvimeghqgDEYDEAL---------STL 178
Cdd:cd12824    85 PSRAVDELR-----RALRDHSSLKSLADLLAQMISGMTKRLELVIFDLTETL---------DEVEDNLldggtapppYAL 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1014087614 179 AELEDIGWKVRLCLMDTQRALNFLVRKArlPGGQLEQAREILRD----IESLLPHNESLFQKVNFLMQAAMGFINIEQNR 254
Cdd:cd12824   151 IALQRRLFRIRRQIRPQQQALRPLITDP--AELLVTSDRETLRRasnnVTRYLETLDFCRTRVALLQDEIKAQRDEKTTR 228

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1014087614 255 IIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIIFMILAGLAPYLYFKRK 313
Cdd:cd12824   229 SSLLLTVVATVFLPLTFITGLLGMNVGGIPDVESPMGFWWVTGLSILVALLAWLLLRRL 287
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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