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Conserved domains on  [gi|949219373|gb|KRP80381|]
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glycerol acyltransferase [Pseudomonas veronii]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 106732)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT super family cl17185
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 89-237 1.24e-06

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


The actual alignment was detected with superfamily member pfam01553:

Pssm-ID: 473073 [Multi-domain]  Cd Length: 131  Bit Score: 47.27  E-value: 1.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949219373   89 VTYTGVEQLKSGTAYVFLANHRdIVMDPAFVNYAVYHAGlPTPRIAIGDNLLQKPFVSDLMRLNKSFIVHRsitgrkEKM 168
Cdd:pfam01553   2 IEVHGLENLPRGGPAIVVANHQ-SYLDVLLLSLALYKRG-RPLVFVAKKELFDIPLVGWLMRLLGCIFIDR------KNR 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 949219373  169 AAYQLLSAYINHSIRHDcQSIWIAqAEGRakdgddRTESAILKMFHVSrkdepFAEVIQSLNLT--PVSIS 237
Cdd:pfam01553  74 KDAAGTLEYLVELLREG-KLVVIF-PEGT------RSREGELLPFKKG-----AFRLAIEAGVPivPVAIS 131
 
Name Accession Description Interval E-value
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 89-237 1.24e-06

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 47.27  E-value: 1.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949219373   89 VTYTGVEQLKSGTAYVFLANHRdIVMDPAFVNYAVYHAGlPTPRIAIGDNLLQKPFVSDLMRLNKSFIVHRsitgrkEKM 168
Cdd:pfam01553   2 IEVHGLENLPRGGPAIVVANHQ-SYLDVLLLSLALYKRG-RPLVFVAKKELFDIPLVGWLMRLLGCIFIDR------KNR 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 949219373  169 AAYQLLSAYINHSIRHDcQSIWIAqAEGRakdgddRTESAILKMFHVSrkdepFAEVIQSLNLT--PVSIS 237
Cdd:pfam01553  74 KDAAGTLEYLVELLREG-KLVVIF-PEGT------RSREGELLPFKKG-----AFRLAIEAGVPivPVAIS 131
LPLAT_DHAPAT-like cd07993
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; ...
 104-290 3.14e-06

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and similar proteins.


Pssm-ID: 153255 [Multi-domain]  Cd Length: 205  Bit Score: 47.57  E-value: 3.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949219373 104 VFLANHRDiVMDPAFVNYAVYHAGLPTPRIAIGDNLLQkPFVSDLMRLNKSFIVHRSItgRKEKMaAYQLLSAYINHSIR 183
Cdd:cd07993   25 VLLPTHRS-YLDFLLLSFILFSLGLPLPHIAAGENLNI-PILGTLLRRLGAFFIRRSF--GKDPL-YRAVLQEYVQELLK 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949219373 184 HDcQSIWIAQAEGRAKDGDDRT-ESAILKMFHVSRKDEPFAEVIqslnLTPVSISYEYDPCDLAKARELYIRATTGTYTK 262
Cdd:cd07993  100 NG-QPLEFFIEGTRSRTGKLLPpKLGLLSVVVEAYLKGSVPDVL----IVPVSISYDRVLEEELYAEELLGPPKPKESLS 174

                        170       180
                 ....*....|....*....|....*....
gi 949219373 263 ApgeddVSIALGITGYK-GRVHVNFAPPI 290
Cdd:cd07993  175 G-----LLGASKILRENfGRIRVDFGEPI 198
PlsB COG2937
Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate ...
 87-139 2.18e-03

Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate O-acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 442180 [Multi-domain]  Cd Length: 707  Bit Score: 40.29  E-value: 2.18e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 949219373  87 DGVTYTGVEQLK---SGTAYVFLANHRDiVMDPAFVNYAVYHAGLPTPRIAIGDNL 139
Cdd:COG2937  186 DGIRVDNLERLRelaKGHEIVYVPCHRS-HMDYLLLSYVLYHNGLVPPHIAAGINL 240
PTZ00374 PTZ00374
dihydroxyacetone phosphate acyltransferase; Provisional
 101-183 4.27e-03

dihydroxyacetone phosphate acyltransferase; Provisional


Pssm-ID: 240389 [Multi-domain]  Cd Length: 1108  Bit Score: 39.47  E-value: 4.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949219373  101 TAYVFLANHRDIVmDPAFVNYAVYHAGLPTPRIAIGDNLLQKPFVSDLMRLNKSFIVHRSItgrKEKMAAYQLLSAYINH 180
Cdd:PTZ00374  629 VAVVLLPLHRSYI-DFIIMTYLLAVMGLPLPHVCAGDDFLRMGPIATLMRGSGAFFMRRSF---RDDPLYAALFKEYVRH 704


                  ...
gi 949219373  181 SIR 183
Cdd:PTZ00374  705 LVL 707
 
Name Accession Description Interval E-value
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 89-237 1.24e-06

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 47.27  E-value: 1.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949219373   89 VTYTGVEQLKSGTAYVFLANHRdIVMDPAFVNYAVYHAGlPTPRIAIGDNLLQKPFVSDLMRLNKSFIVHRsitgrkEKM 168
Cdd:pfam01553   2 IEVHGLENLPRGGPAIVVANHQ-SYLDVLLLSLALYKRG-RPLVFVAKKELFDIPLVGWLMRLLGCIFIDR------KNR 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 949219373  169 AAYQLLSAYINHSIRHDcQSIWIAqAEGRakdgddRTESAILKMFHVSrkdepFAEVIQSLNLT--PVSIS 237
Cdd:pfam01553  74 KDAAGTLEYLVELLREG-KLVVIF-PEGT------RSREGELLPFKKG-----AFRLAIEAGVPivPVAIS 131
LPLAT_DHAPAT-like cd07993
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; ...
 104-290 3.14e-06

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and similar proteins.


Pssm-ID: 153255 [Multi-domain]  Cd Length: 205  Bit Score: 47.57  E-value: 3.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949219373 104 VFLANHRDiVMDPAFVNYAVYHAGLPTPRIAIGDNLLQkPFVSDLMRLNKSFIVHRSItgRKEKMaAYQLLSAYINHSIR 183
Cdd:cd07993   25 VLLPTHRS-YLDFLLLSFILFSLGLPLPHIAAGENLNI-PILGTLLRRLGAFFIRRSF--GKDPL-YRAVLQEYVQELLK 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949219373 184 HDcQSIWIAQAEGRAKDGDDRT-ESAILKMFHVSRKDEPFAEVIqslnLTPVSISYEYDPCDLAKARELYIRATTGTYTK 262
Cdd:cd07993  100 NG-QPLEFFIEGTRSRTGKLLPpKLGLLSVVVEAYLKGSVPDVL----IVPVSISYDRVLEEELYAEELLGPPKPKESLS 174

                        170       180
                 ....*....|....*....|....*....
gi 949219373 263 ApgeddVSIALGITGYK-GRVHVNFAPPI 290
Cdd:cd07993  175 G-----LLGASKILRENfGRIRVDFGEPI 198
PlsB COG2937
Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate ...
 87-139 2.18e-03

Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate O-acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 442180 [Multi-domain]  Cd Length: 707  Bit Score: 40.29  E-value: 2.18e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 949219373  87 DGVTYTGVEQLK---SGTAYVFLANHRDiVMDPAFVNYAVYHAGLPTPRIAIGDNL 139
Cdd:COG2937  186 DGIRVDNLERLRelaKGHEIVYVPCHRS-HMDYLLLSYVLYHNGLVPPHIAAGINL 240
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 88-160 2.33e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 38.79  E-value: 2.33e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 949219373  88 GVTYTGVEQLKSGTAYVFLANHRDIvMDPAFVNYAVyhagLPTPRIAIGDNLLQKPFVSDLMRLNKSFIVHRS 160
Cdd:cd07989   11 RVRVEGLENLPPKGPVIIVANHQSY-LDPLVLGAAL----PRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRG 78
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 89-201 2.55e-03

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 38.84  E-value: 2.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949219373  89 VTYTGVEQLKSGTAYVFLANHRdIVMDPAFVNYAVYHaglpTPRIAIGDNLLQKPFVSDLMRLNKSFIVHRSitGRKEKM 168
Cdd:COG0204   31 VRVEGLENLPADGPVLIVANHQ-SWLDILLLLAALPR----PVRFVAKKELFKIPLLGWLLRALGAIPVDRS--KRRAAL 103

                         90       100       110
                 ....*....|....*....|....*....|....
gi 949219373 169 AAYQLLSAYINHSirhdcQSIWIAqAEG-RAKDG 201
Cdd:COG0204  104 RALRQAVEALKAG-----ESLVIF-PEGtRSPDG 131
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 89-241 2.82e-03

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 38.55  E-value: 2.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949219373  89 VTYTGVEQLKSGTAYVFLANHRdIVMDPAFVNYAVYHAGLPTPRIAIGDNLLQK-PFVSdlmRLNKSFIVHRSITGRKEK 167
Cdd:cd06551   14 LEVKGPPPPPGGGPVLFVSNHS-SWWDGLILFLLLERGLRRDVYGLMDEELLERyPFFT---RLGAFSVDRDSPRSAAKS 89

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 949219373 168 MaayqllsAYINHSIRHDCQSIWIAqAEGRAKDGDDRtesaiLKMFHVSrkdepFAEVIQSLNLT--PVSISYEYD 241
Cdd:cd06551   90 L-------KYVARLLSKPGSVVWIF-PEGTRTRRDKR-----PLQFKPG-----VAHLAEKAGVPivPVALRYTFE 147
PTZ00374 PTZ00374
dihydroxyacetone phosphate acyltransferase; Provisional
 101-183 4.27e-03

dihydroxyacetone phosphate acyltransferase; Provisional


Pssm-ID: 240389 [Multi-domain]  Cd Length: 1108  Bit Score: 39.47  E-value: 4.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 949219373  101 TAYVFLANHRDIVmDPAFVNYAVYHAGLPTPRIAIGDNLLQKPFVSDLMRLNKSFIVHRSItgrKEKMAAYQLLSAYINH 180
Cdd:PTZ00374  629 VAVVLLPLHRSYI-DFIIMTYLLAVMGLPLPHVCAGDDFLRMGPIATLMRGSGAFFMRRSF---RDDPLYAALFKEYVRH 704


                  ...
gi 949219373  181 SIR 183
Cdd:PTZ00374  705 LVL 707
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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