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Conserved domains on  [gi|844664158|gb|KMJ32341|]
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galactitol utilization operon repressor [Salmonella enterica subsp. enterica serovar Typhimurium]

Protein Classification

DeoR/GlpR family DNA-binding transcription regulator( domain architecture ID 11442564)

DeoR/GlpR family DNA-binding transcription regulator is a helix-turn-helix type transcriptional regulator that may be involved in sugar metabolism

Gene Ontology:  GO:0003700|GO:0003677
PubMed:  15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 1-257 1.45e-101

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


:

Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 295.89  E-value: 1.45e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158   1 MNSFERRNKIVDLINTQGSVLVMDLSNTFGISEVTIRADLRLLEEKGLVTRFHGGAAKPGSHLAEGDnqeviLEDRYQLA 80
Cdd:COG1349    1 MLAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPP-----FAERETLN 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158  81 SDPKKRIAQAAAAMVEEGMTIILDSGSTTLLIAEALARKSNITVITNSLPAAFTLSENKDLTLVVCGGTVRHKTHSMHGT 160
Cdd:COG1349   76 AEEKRAIARAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGP 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158 161 IAERSLHGISADLMFVGADGIDATNGITTFNEG-YSISGVMAAAAHKVIAVLDATKFNRRGFNQVLPMDKIDCVITDDTI 239
Cdd:COG1349  156 LAEEALRRFRADKAFLGASGIDAEGGLTTFDEEeAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGP 235

                        250
                 ....*....|....*...
gi 844664158 240 SKQDKAALAKTGVELMIV 257
Cdd:COG1349  236 PPELLEALEEAGVEVIVA 253
 
Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 1-257 1.45e-101

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 295.89  E-value: 1.45e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158   1 MNSFERRNKIVDLINTQGSVLVMDLSNTFGISEVTIRADLRLLEEKGLVTRFHGGAAKPGSHLAEGDnqeviLEDRYQLA 80
Cdd:COG1349    1 MLAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPP-----FAERETLN 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158  81 SDPKKRIAQAAAAMVEEGMTIILDSGSTTLLIAEALARKSNITVITNSLPAAFTLSENKDLTLVVCGGTVRHKTHSMHGT 160
Cdd:COG1349   76 AEEKRAIARAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGP 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158 161 IAERSLHGISADLMFVGADGIDATNGITTFNEG-YSISGVMAAAAHKVIAVLDATKFNRRGFNQVLPMDKIDCVITDDTI 239
Cdd:COG1349  156 LAEEALRRFRADKAFLGASGIDAEGGLTTFDEEeAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGP 235

                        250
                 ....*....|....*...
gi 844664158 240 SKQDKAALAKTGVELMIV 257
Cdd:COG1349  236 PPELLEALEEAGVEVIVA 253
srlR PRK10434
DNA-binding transcriptional repressor;
1-257 1.33e-72

DNA-binding transcriptional repressor;


Pssm-ID: 182457 [Multi-domain]  Cd Length: 256  Bit Score: 222.26  E-value: 1.33e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158   1 MNSFERRNKIVDLINTQGSVLVMDLSNTFGISEVTIRADLRLLEEKGLVTRFHGGAakpgshLAEGDNQEVILEDRYQLA 80
Cdd:PRK10434   1 MKPRQRQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGV------VLNKEESDPPIDHKTLIN 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158  81 SDPKKRIAQAAAAMVEEGMTIILDSGSTTLLIAEALARKSNITVITNSLPAAFTLSE-NKDLTLVVCGGTVRHKTHSMHG 159
Cdd:PRK10434  75 THKKELIAEAAVSLIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSElDNEQTILMPGGTFRKKSASFHG 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158 160 TIAERSLHGISADLMFVGADGIDATNGITTFNEGYSISGVMAAAAHKVIAVLDATKFNRRGFNQVLPMDKIDCVITDDTI 239
Cdd:PRK10434 155 QLAENAFEHFTFDKLFIGTDGIDLNAGVTTFNEVYTVSKAMCNAAREIILMADSSKFGRKSPNVVCSLEKVDKLITDAGI 234

                        250
                 ....*....|....*...
gi 844664158 240 SKQDKAALAKTGVELMIV 257
Cdd:PRK10434 235 DPAFRQALEEKGIEVIIT 252
AgaR NF040755
transcriptional repressor AgaR;
1-257 3.32e-71

transcriptional repressor AgaR;


Pssm-ID: 468715 [Multi-domain]  Cd Length: 256  Bit Score: 218.68  E-value: 3.32e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158   1 MNSFERRNKIVDLINTQGSVLVMDLSNTFGISEVTIRADLRLLEEKGLVTRFHGGAAkPGSHLAEGdnQEVILEDRYQLA 80
Cdd:NF040755   2 KGTSERREQIIQRLRQQGSVQVEDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGGAL-INDGFIPG--AEPSVEDKSRLN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158  81 SDPKKRIAQAAAAMVEEGMTIILDSGSTTLLIAEALARKSNITVITNSLPAAFTLSENKDLTLVVCGGTVRHKTHSMHGT 160
Cdd:NF040755  79 TAVKRLIAAAAAELIKPGDRVILDSGTTTYEIARHLKQHQDVVVMTNGLNVANELLEAEGVEVLMTGGHLRRQSLSFYGD 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158 161 IAERSLHGISADLMFVGADGIDATNGITTFNEG-YSISGVMAAAAHKVIAVLDATKFNRRGFNQVLPMDKIDCVITDDTI 239
Cdd:NF040755 159 QAEQSLQNYHFDKLFLGVDGFDLERGITTHNEDeARLNRRMCEVAERIIAVTDSSKFGRSSLHKIRDTGRIDTLITDSGI 238

                        250
                 ....*....|....*...
gi 844664158 240 SKQDKAALAKTGVELMIV 257
Cdd:NF040755 239 PEEYLQGLRKLGVEVILV 256
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 84-236 1.15e-59

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 186.18  E-value: 1.15e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158   84 KKRIAQAAAAMVEEGMTIILDSGSTTLLIAEALARKSNITVITNSLPAAFTLSENKDLTLVVCGGTVRHKTHSMHGTIAE 163
Cdd:pfam00455   6 KRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRRNLTVITNSLNIANELSEKPDIEVILLGGEVRPKTGAFVGPLAE 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 844664158  164 RSLHGISADLMFVGADGIDATNGITTFNEG-YSISGVMAAAAHKVIAVLDATKFNRRGFNQVLPMDKIDCVITD 236
Cdd:pfam00455  86 EFLRQFNVDKAFIGANGIDLEGGLTTSDEEeAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITD 159
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
6-57 8.45e-14

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 64.17  E-value: 8.45e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 844664158     6 RRNKIVDLINTQGSVLVMDLSNTFGISEVTIRADLRLLEEKGLVTRFHGGAA 57
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGAV 52
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 8-54 4.84e-04

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 37.43  E-value: 4.84e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 844664158   8 NKIVDLINTQ----GSVL--VMDLSNTFGISEVTIRADLRLLEEKGLVTRFHG 54
Cdd:cd07377    8 DQLREAILSGelkpGDRLpsERELAEELGVSRTTVREALRELEAEGLVERRPG 60
rpiA TIGR00021
ribose 5-phosphate isomerase; This model describes ribose 5-phosphate isomerase, an enzyme of ...
 84-128 2.05e-03

ribose 5-phosphate isomerase; This model describes ribose 5-phosphate isomerase, an enzyme of the non-oxidative branch of the pentose phosphate pathway. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 272859  Cd Length: 218  Bit Score: 38.36  E-value: 2.05e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 844664158   84 KKRIA-QAAAAMVEEGMTIILDSGSTTLLIAEALARK-----SNITVITNS 128
Cdd:TIGR00021   1 LKRAAaEAAAEYVEDGMVVGLGTGSTVAYFIEALGERvkqegLDIVGVPTS 51
 
Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 1-257 1.45e-101

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 295.89  E-value: 1.45e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158   1 MNSFERRNKIVDLINTQGSVLVMDLSNTFGISEVTIRADLRLLEEKGLVTRFHGGAAKPGSHLAEGDnqeviLEDRYQLA 80
Cdd:COG1349    1 MLAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPP-----FAERETLN 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158  81 SDPKKRIAQAAAAMVEEGMTIILDSGSTTLLIAEALARKSNITVITNSLPAAFTLSENKDLTLVVCGGTVRHKTHSMHGT 160
Cdd:COG1349   76 AEEKRAIARAAASLIEDGDTIFLDAGTTTLALARALPDRRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGP 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158 161 IAERSLHGISADLMFVGADGIDATNGITTFNEG-YSISGVMAAAAHKVIAVLDATKFNRRGFNQVLPMDKIDCVITDDTI 239
Cdd:COG1349  156 LAEEALRRFRADKAFLGASGIDAEGGLTTFDEEeAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAGP 235

                        250
                 ....*....|....*...
gi 844664158 240 SKQDKAALAKTGVELMIV 257
Cdd:COG1349  236 PPELLEALEEAGVEVIVA 253
srlR PRK10434
DNA-binding transcriptional repressor;
1-257 1.33e-72

DNA-binding transcriptional repressor;


Pssm-ID: 182457 [Multi-domain]  Cd Length: 256  Bit Score: 222.26  E-value: 1.33e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158   1 MNSFERRNKIVDLINTQGSVLVMDLSNTFGISEVTIRADLRLLEEKGLVTRFHGGAakpgshLAEGDNQEVILEDRYQLA 80
Cdd:PRK10434   1 MKPRQRQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGV------VLNKEESDPPIDHKTLIN 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158  81 SDPKKRIAQAAAAMVEEGMTIILDSGSTTLLIAEALARKSNITVITNSLPAAFTLSE-NKDLTLVVCGGTVRHKTHSMHG 159
Cdd:PRK10434  75 THKKELIAEAAVSLIHDGDSIILDAGSTVLQMVPLLSRFNNITVMTNSLHIVNALSElDNEQTILMPGGTFRKKSASFHG 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158 160 TIAERSLHGISADLMFVGADGIDATNGITTFNEGYSISGVMAAAAHKVIAVLDATKFNRRGFNQVLPMDKIDCVITDDTI 239
Cdd:PRK10434 155 QLAENAFEHFTFDKLFIGTDGIDLNAGVTTFNEVYTVSKAMCNAAREIILMADSSKFGRKSPNVVCSLEKVDKLITDAGI 234

                        250
                 ....*....|....*...
gi 844664158 240 SKQDKAALAKTGVELMIV 257
Cdd:PRK10434 235 DPAFRQALEEKGIEVIIT 252
AgaR NF040755
transcriptional repressor AgaR;
1-257 3.32e-71

transcriptional repressor AgaR;


Pssm-ID: 468715 [Multi-domain]  Cd Length: 256  Bit Score: 218.68  E-value: 3.32e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158   1 MNSFERRNKIVDLINTQGSVLVMDLSNTFGISEVTIRADLRLLEEKGLVTRFHGGAAkPGSHLAEGdnQEVILEDRYQLA 80
Cdd:NF040755   2 KGTSERREQIIQRLRQQGSVQVEDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGGAL-INDGFIPG--AEPSVEDKSRLN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158  81 SDPKKRIAQAAAAMVEEGMTIILDSGSTTLLIAEALARKSNITVITNSLPAAFTLSENKDLTLVVCGGTVRHKTHSMHGT 160
Cdd:NF040755  79 TAVKRLIAAAAAELIKPGDRVILDSGTTTYEIARHLKQHQDVVVMTNGLNVANELLEAEGVEVLMTGGHLRRQSLSFYGD 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158 161 IAERSLHGISADLMFVGADGIDATNGITTFNEG-YSISGVMAAAAHKVIAVLDATKFNRRGFNQVLPMDKIDCVITDDTI 239
Cdd:NF040755 159 QAEQSLQNYHFDKLFLGVDGFDLERGITTHNEDeARLNRRMCEVAERIIAVTDSSKFGRSSLHKIRDTGRIDTLITDSGI 238

                        250
                 ....*....|....*...
gi 844664158 240 SKQDKAALAKTGVELMIV 257
Cdd:NF040755 239 PEEYLQGLRKLGVEVILV 256
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 84-236 1.15e-59

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 186.18  E-value: 1.15e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158   84 KKRIAQAAAAMVEEGMTIILDSGSTTLLIAEALARKSNITVITNSLPAAFTLSENKDLTLVVCGGTVRHKTHSMHGTIAE 163
Cdd:pfam00455   6 KRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRRNLTVITNSLNIANELSEKPDIEVILLGGEVRPKTGAFVGPLAE 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 844664158  164 RSLHGISADLMFVGADGIDATNGITTFNEG-YSISGVMAAAAHKVIAVLDATKFNRRGFNQVLPMDKIDCVITD 236
Cdd:pfam00455  86 EFLRQFNVDKAFIGANGIDLEGGLTTSDEEeAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITD 159
PRK09802 PRK09802
DeoR family transcriptional regulator;
2-257 4.57e-57

DeoR family transcriptional regulator;


Pssm-ID: 182086 [Multi-domain]  Cd Length: 269  Bit Score: 183.13  E-value: 4.57e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158   2 NSFERRNKIVDLINTQGSVLVMDLSNTFGISEVTIRADLRLLEEKGLVTRFHGGAAKPGSHLAegdNQEVILEDRYQLAS 81
Cdd:PRK09802  14 GTSERREQIIQRLRQQGSVQVNDLSALYGVSTVTIRNDLAFLEKQGIAVRAYGGALICDSTTP---SVEPSVEDKSALNT 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158  82 DPKKRIAQAAAAMVEEGMTIILDSGSTTLLIAEALARKSNITVITNSLPAAFTLSENKDLTLVVCGGTVRHKTHSMHGTI 161
Cdd:PRK09802  91 AMKRSVAKAAVELIQPGHRVILDSGTTTFEIARLMRKHTDVIAMTNGMNVANALLEAEGVELLMTGGHLRRQSQSFYGDQ 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158 162 AERSLHGISADLMFVGADGIDATNGITTFNEGYS-ISGVMAAAAHKVIAVLDATKFNRRGFNQVLPMDKIDCVITDDTIS 240
Cdd:PRK09802 171 AEQSLQNYHFDMLFLGVDAIDLERGVSTHNEDEArLNRRMCEVAERIIVVTDSSKFNRSSLHKIIDTQRIDMIIVDEGIP 250

                        250
                 ....*....|....*..
gi 844664158 241 KQDKAALAKTGVELMIV 257
Cdd:PRK09802 251 ADSLEGLRKAGVEVILV 267
PRK10906 PRK10906
DeoR/GlpR family transcriptional regulator;
1-238 8.41e-31

DeoR/GlpR family transcriptional regulator;


Pssm-ID: 182827 [Multi-domain]  Cd Length: 252  Bit Score: 114.57  E-value: 8.41e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158   1 MNSFERRNKIVDLINTQGSVLVMDLSNTFGISEVTIRADLRLLEEKGLVTRFHGGAAKPGShlaegdNQEVILEDRYQLA 80
Cdd:PRK10906   1 MKQTQRHDAIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNDLAEQNKILRHHGGAALPSS------SVNTPWHDRKATQ 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158  81 SDPKKRIAQAAAAMVEEGMTIILDSGSTTLLIAEALARKSNITVITNSLPAAFTLSENKDLTLVVCGGTVRHKThsmHGT 160
Cdd:PRK10906  75 TEEKERIARKVASQIPNGATLFIDIGTTPEAVAHALLNHSNLRIVTNNLNVANTLMAKEDFRIILAGGELRSRD---GGI 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158 161 IAERSLHGISA---DLMFVGADGIDATNGITTFN--EGYSISGVMAAAAHkVIAVLDATKFNRRGFNQVLPMDKIDCVIT 235
Cdd:PRK10906 152 IGEATLDFISQfrlDFGILGISGIDSDGSLLEFDyhEVRTKRAIIENSRH-VMLVVDHSKFGRNAMVNMGSISMVDAVYT 230


                 ...
gi 844664158 236 DDT 238
Cdd:PRK10906 231 DQL 233
PRK13509 PRK13509
HTH-type transcriptional regulator UlaR;
1-257 6.51e-28

HTH-type transcriptional regulator UlaR;


Pssm-ID: 184100 [Multi-domain]  Cd Length: 251  Bit Score: 107.01  E-value: 6.51e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158   1 MNSFERRNKIVDLINTQGSVLVMDLSNTFGISEVTIRADLRLLEEKGLVTRFHGGAakpgshlaegdnqEVILEDRYQLA 80
Cdd:PRK13509   1 MTEAQRHQILLELLAQLGFVTVEKVIERLGISPATARRDINKLDESGKLKKVRNGA-------------EAITQQRPRWT 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158  81 ---------SDPKKRIAQAAAAMVEEGMTIILDSGSTTLLIAEALARKsNITVITNSLPAAFTLSENKDLTLVVCGGTVr 151
Cdd:PRK13509  68 pmnihqaqnHDEKVRIAKAASQLCNPGESVVINCGSTAFLLGRELCGK-PVQIITNYLPLANYLIDQEHDSVIIMGGQY- 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158 152 HKTHSMHGTIAERSLHGISADLMF-----VGADGIDATNGITTFNEGYsisgvMAAAAHKVIAVLDATKFNRRGFNQVLP 226
Cdd:PRK13509 146 NKSQSITLSPQGSENSLYAGHWMFtsgkgLTADGLYKTDMLTAMAEQK-----MLSVVGKLVVLVDSSKIGERAGMLFSR 220

                        250       260       270
                 ....*....|....*....|....*....|.
gi 844664158 227 MDKIDCVITDDTISKQDKAALAKTGVELMIV 257
Cdd:PRK13509 221 ADQIDMLITGKNADPEVLQQLEAQGVSILLV 251
PRK10411 PRK10411
L-fucose operon activator;
5-238 1.15e-21

L-fucose operon activator;


Pssm-ID: 236684 [Multi-domain]  Cd Length: 240  Bit Score: 90.25  E-value: 1.15e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158   5 ERRNKIVDLINTQGSVLVMDLSNTFGISEVTIRADLRLLEEKGLVTRFHGGA-AKPGSHLAEGDNQEVILEDRYQLASDp 83
Cdd:PRK10411   4 ARQQAIVDLLLNHTSLTTEALAEQLNVSKETIRRDLNELQTQGKILRNHGRAkYIHRQNQDSGDPFHIRLKSHYAHKAD- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158  84 kkrIAQAAAAMVEEGMTIILDSGSTTLLIAEALArKSNITVITNSLPAAFTLSENKDLTLVVCGGTVRHKTHSMHGTIAE 163
Cdd:PRK10411  83 ---IAREALAWIEEGMVIALDASSTCWYLARQLP-DINIQVFTNSHPICQELGKRERIQLISSGGTLERKYGCYVNPSLI 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 844664158 164 RSLHGISADLMFVGADGIDATNGI---TTFNEGYSiSGVMAAAAHKVIaVLDATKFNRRGFNQVLPMDKIDCVITDDT 238
Cdd:PRK10411 159 SQLKSLEIDLFIFSCEGIDSSGALwdsNAINADYK-SMLLKRAAQSLL-LIDKSKFNRSGEARIGHLDEVTHIISDER 234
PRK10681 PRK10681
DNA-binding transcriptional repressor DeoR; Provisional
 5-236 2.96e-17

DNA-binding transcriptional repressor DeoR; Provisional


Pssm-ID: 182644 [Multi-domain]  Cd Length: 252  Bit Score: 78.59  E-value: 2.96e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158   5 ERRNKIVDLINTQGSVLVMDLSNTFGISEVTIRADLRllEEKGLVTRFhGG----AAKPGSHLAEGDNQEVILEDryqla 80
Cdd:PRK10681   7 ERIGQLLQALKRSDKLHLKDAAALLGVSEMTIRRDLN--AHSAPVVLL-GGyivlEPRSASHYLLSDQKSRLVEE----- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158  81 sdpKKRIAQAAAAMVEEGMTIILDSGSTTLLIAEALARKSNITVITNSLPAAFTLSENKDLTLVVCGGTVrHKTHSMHGT 160
Cdd:PRK10681  79 ---KRRAAQLAATLVEPNQTLFFDCGTTTPWIIEAIDNELPFTAVCYSLNTFLALQEKPHCRAILCGGEF-HASNAIFKP 154

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 844664158 161 IAERS-LHGISADLMFVGADGIDATNGITTFN--EGYSISGVMAAAAHKVIaVLDATKFNRRGFNQVLPMDKIDCVITD 236
Cdd:PRK10681 155 LDFQQtLDNICPDIAFYSAAGVHVSKGATCFNleELPVKHWAMAMAQKHVL-VVDHSKFGKVRPARMGDLTRFDTVVSD 232
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
6-57 8.45e-14

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 64.17  E-value: 8.45e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 844664158     6 RRNKIVDLINTQGSVLVMDLSNTFGISEVTIRADLRLLEEKGLVTRFHGGAA 57
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGAV 52
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
6-57 7.32e-13

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 61.51  E-value: 7.32e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 844664158    6 RRNKIVDLINTQGSVLVMDLSNTFGISEVTIRADLRLLEEKGLVTRFHGGAA 57
Cdd:pfam08220   1 RIQQILELLKQQGTLSVEELAELLGVSEMTIRRDLNELEEQGLLTRTHGGAV 52
DeoR COG2390
DNA-binding transcriptional regulator LsrR, DeoR family [Transcription];
24-125 6.90e-06

DNA-binding transcriptional regulator LsrR, DeoR family [Transcription];


Pssm-ID: 441955 [Multi-domain]  Cd Length: 301  Bit Score: 46.28  E-value: 6.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158  24 DLSNTFGISEVTIRADLRLLEEKGLVT-RFHggaakpgSHLAEGDNQEVILEDRYQL------------ASDPKKRIAQA 90
Cdd:COG2390   15 EIAERLGISRRTVSRLLAEAREEGLVRiSIT-------DPLAGLLELERELRERFGLkevivvpgdsddDEEVLRALGRA 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 844664158  91 AAAMVEE----GMTIILDSGSTTLLIAEALARKS--NITVI 125
Cdd:COG2390   88 AAEYLERllkdGDVIGVGWGRTLAAVAEALPPLPlpDVTVV 128
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 7-57 3.49e-05

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 40.68  E-value: 3.49e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 844664158    7 RNKIVDLINTQGSVL--VMDLSNTFGISEVTIRADLRLLEEKGLVTRFHGGAA 57
Cdd:pfam00392  10 REDILSGRLRPGDKLpsERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGT 62
CoA_trans smart00882
Coenzyme A transferase; Coenzyme A (CoA) transferases belong to an evolutionary conserved ...
 87-257 1.11e-04

Coenzyme A transferase; Coenzyme A (CoA) transferases belong to an evolutionary conserved family of enzymes catalyzing the reversible transfer of CoA from one carboxylic acid to another. They have been identified in many prokaryotes and in mammalian tissues. The bacterial enzymes are heterodimer of two subunits (A and B) of about 25 Kd each while eukaryotic SCOT consist of a single chain which is colinear with the two bacterial subunits.


Pssm-ID: 214882 [Multi-domain]  Cd Length: 212  Bit Score: 42.19  E-value: 1.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158    87 IAQAAAAMVEEGMTIILDSGSTT-----LLIAEALARKSNITVITNSlpAAFTLS---ENKDLTLVVCG-GTVRHKTHSM 157
Cdd:smart00882   1 SAAEAAREIKDGDTVALGGFGGLptpaaLILALIRQGPKDLTLISEN--GGLGLGllaGEGDVKKIIAGhVGLTPLLGRL 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158   158 --HGTI-AERSLHGISADLMFVGADGIDAT---NGITTFNEGYSISG-----------VMAAAAHKVIAVLDATKFNRRG 220
Cdd:smart00882  79 yfDGEIeSFLLPQGGLADRLRAGAAGVPGFgtlAGLGTDVDPRYEGGkvrpfgmggayLLVPAIRPDVALIRAHTADEFG 158

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 844664158   221 fNQVlpMDKIDCVITDDTIskqdKAALAKTGVELMIV 257
Cdd:smart00882 159 -NLV--YEKEATSCGLPLT----AAAAKKVIVQVEEI 188
PRK00702 PRK00702
ribose-5-phosphate isomerase RpiA;
84-128 3.31e-04

ribose-5-phosphate isomerase RpiA;


Pssm-ID: 234816  Cd Length: 220  Bit Score: 40.82  E-value: 3.31e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 844664158  84 KKRIAQAAAAMVEEGMTIILDSGSTTLLIAEALARK----SNITVITNS 128
Cdd:PRK00702   7 KKAAAEAAAEYVEDGMIVGLGTGSTAAYFIDALGERvkegLIIGGVPTS 55
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 8-54 4.84e-04

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 37.43  E-value: 4.84e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 844664158   8 NKIVDLINTQ----GSVL--VMDLSNTFGISEVTIRADLRLLEEKGLVTRFHG 54
Cdd:cd07377    8 DQLREAILSGelkpGDRLpsERELAEELGVSRTTVREALRELEAEGLVERRPG 60
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
7-56 4.99e-04

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 37.55  E-value: 4.99e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 844664158     7 RNKIVDLINTQGSVL--VMDLSNTFGISEVTIRADLRLLEEKGLVTRFHGGA 56
Cdd:smart00345   6 REDIVSGELRPGDKLpsERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSG 57
IF-2B pfam01008
Initiation factor 2 subunit family; This family includes initiation factor 2B alpha, beta and ...
 87-219 1.08e-03

Initiation factor 2 subunit family; This family includes initiation factor 2B alpha, beta and delta subunits from eukaryotes, initiation factor 2B subunits 1 and 2 from archaebacteria and some proteins of unknown function from prokaryotes. Initiation factor 2 binds to Met-tRNA, GTP and the small ribosomal subunit. Members of this family have also been characterized as 5-methylthioribose- 1-phosphate isomerases, an enzyme of the methionine salvage pathway. The crystal structure of Ypr118w, a non-essential, low-copy number gene product from Saccharomyces cerevisiae, reveals a dimeric protein with two domains and a putative active site cleft.


Pssm-ID: 395798 [Multi-domain]  Cd Length: 281  Bit Score: 39.58  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158   87 IAQAAAAMVEEGMTI--ILDSGSTTLLIAEALARKSNITVI-TNSLP------AAFTLSENK-DLTLVvcggtvrhkTHS 156
Cdd:pfam01008  97 IGAIAAELIKDGDTIltHCNSGTVLGVLRAAHKEGKRFRVIvTESRPrlqgrlTAKELVQAGiPVTLI---------TDS 167

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 844664158  157 MHGTIAERslhgisADLMFVGADGIdATNGITTFNEGYSISGVMAAAAHK-VIAVLDATKFNRR 219
Cdd:pfam01008 168 AVGYVMQE------VDKVIVGADRI-LANGGIANKIGTYQLALLAKAHNVpFYVVAETYKFDPR 224
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
5-97 1.28e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 39.14  E-value: 1.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844664158   5 ERRNKIVDLINTQGSVLVMDLSNTFGISEVTIRADLRLLEEKGLVTRF--HGGAAKPgSHL----AEGDNQeviLEDRYQ 78
Cdd:COG2345   13 PTRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVEREteRRGRGRP-AKLyrltEAGRAR---FPRAYD 88

                         90
                 ....*....|....*....
gi 844664158  79 LasdpkkrIAQAAAAMVEE 97
Cdd:COG2345   89 D-------LAVALLDALRE 100
rpiA TIGR00021
ribose 5-phosphate isomerase; This model describes ribose 5-phosphate isomerase, an enzyme of ...
 84-128 2.05e-03

ribose 5-phosphate isomerase; This model describes ribose 5-phosphate isomerase, an enzyme of the non-oxidative branch of the pentose phosphate pathway. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 272859  Cd Length: 218  Bit Score: 38.36  E-value: 2.05e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 844664158   84 KKRIA-QAAAAMVEEGMTIILDSGSTTLLIAEALARK-----SNITVITNS 128
Cdd:TIGR00021   1 LKRAAaEAAAEYVEDGMVVGLGTGSTVAYFIEALGERvkqegLDIVGVPTS 51
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
23-54 2.05e-03

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 38.30  E-value: 2.05e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 844664158  23 MDLSNTFGISEVTIRADLRLLEEKGLVTRFHG 54
Cdd:COG2188   33 RELAEEFGVSRMTVRKALDELVEEGLLERRQG 64
YobV COG2378
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains ...
 1-45 3.13e-03

Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains [Transcription];


Pssm-ID: 441945 [Multi-domain]  Cd Length: 314  Bit Score: 38.14  E-value: 3.13e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 844664158   1 MNSFERRNKIVDLINTQGSVLVMDLSNTFGISEVTIRADLRLLEE 45
Cdd:COG2378    1 MSRLERLLALLQLLQSRRGVTAAELAERLEVSERTIYRDIDALRE 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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