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Conserved domains on  [gi|839495802|gb|KMF71786|]
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response regulator membrane protein [Klebsiella pneumoniae]

Protein Classification

SLC13 family permease( domain architecture ID 18423072)

SLC13 (solute carrier 13) family permease is a sodium-coupled symporter that facilitates the transport across biological membranes of various ions including sulfate or Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate; may function as a regulator

Gene Ontology:  GO:0008324
PubMed:  23506872|12915942|24114175

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
61-610 2.21e-62

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


:

Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 210.40  E-value: 2.21e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802  61 AALFIIGDGLVRTGVATKMGAWLVSVAGNSETKMLIYLMLTVAGLGAFMSSTGVVAIFIPVVLSVSARM-----NTSPSR 135
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALgsekrSKFGSA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 136 LMMPLSFAGLISGMMTLVATPPNLVVNSELLREGLHGFSFFSVTPIGLVVLILGIVYMLAVRfmlktdngdsardgrkrs 215
Cdd:COG0471   81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIPISFFEWMLVGLPVALVGLLLLWLVL------------------ 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 216 tfrdlireyhltgrarrlairpgspmigqrlddlklrerycanvigverWRRFRRVIVNVNGVSEfrardvllidmsasd 295
Cdd:COG0471  143 -------------------------------------------------YRLLPPEIKEVPGSKE--------------- 158

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 296 vdlrqfcgeqmlepmVLRGEYfadqaldvgmaevalipdSEMIGKTVREIafrtrfglnivgmkrdgkamdgsvvdeplq 375
Cdd:COG0471  159 ---------------VIREEL------------------AELGPLSRREK------------------------------ 175

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 376 lgdillvvgnwrqiallakrgrdfvvlnmpvevddaspahsqapHAIFCLVLMVALMLTDE---IPNPIAAIIACLLMGK 452
Cdd:COG0471  176 --------------------------------------------IALAIFALTVLLWITGSlhgIPIAVVALLGAVLLLL 211

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 453 FRCINAESAYKAIHWPSIILIVGMMPFALALQKTGGVDLVVKGLMDVAGGEGPYLMLGCLFMMCAAIGLFISNTATAVLM 532
Cdd:COG0471  212 TGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPLLGGLSPLLLLLLLALLTLLLTEFASNTATAALL 291

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 839495802 533 APIALAAAKSMGVSPYPFAMVVAMAASAAFMTPVSSPVNTLVLGPGKYSFSDFVKIGVPFTILVMVVCVLLIPVLFPF 610
Cdd:COG0471  292 LPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWPL 369
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 303-395 8.41e-13

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


:

Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 66.10  E-value: 8.41e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 303 GEQMLEPMVLRGEYFADQALDVGMAEVALIPDSEMIGKTVREIAFRTRFGLNIVGMKRDGKAMDGSVVDEPLQLGDILLV 382
Cdd:COG0490   47 LLLLGELLRLLTRLLIELVLLLAIEEVKVPPGSPLVGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVV 126

                         90
                 ....*....|...
gi 839495802 383 VGNWRQIALLAKR 395
Cdd:COG0490  127 VGTREQLERLEEL 139
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 159-289 8.79e-06

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


:

Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 45.68  E-value: 8.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 159 LVVNSELLREGLHGFSFFSVTPIGLVVLILGIVYMLAVRFMLktDNGDSARDGRKRSTFRDLIREYHLTgRARRLAIRPG 238
Cdd:COG0490    2 ALALLLLLIILLLLLALAALLVAIVIVGVLGLILRGLLLLEL--ALLLLLLGELLRLLTRLLIELVLLL-AIEEVKVPPG 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 839495802 239 SPMIGQRLDDLKLRERYCANVIGVerwRRFRRVIVNVNGVSEFRARDVLLI 289
Cdd:COG0490   79 SPLVGKTLGELNLRQRTGVTVVAI---RRGGEVILSPGPDTVLEAGDTLVV 126
 
Name Accession Description Interval E-value
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
61-610 2.21e-62

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 210.40  E-value: 2.21e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802  61 AALFIIGDGLVRTGVATKMGAWLVSVAGNSETKMLIYLMLTVAGLGAFMSSTGVVAIFIPVVLSVSARM-----NTSPSR 135
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALgsekrSKFGSA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 136 LMMPLSFAGLISGMMTLVATPPNLVVNSELLREGLHGFSFFSVTPIGLVVLILGIVYMLAVRfmlktdngdsardgrkrs 215
Cdd:COG0471   81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIPISFFEWMLVGLPVALVGLLLLWLVL------------------ 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 216 tfrdlireyhltgrarrlairpgspmigqrlddlklrerycanvigverWRRFRRVIVNVNGVSEfrardvllidmsasd 295
Cdd:COG0471  143 -------------------------------------------------YRLLPPEIKEVPGSKE--------------- 158

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 296 vdlrqfcgeqmlepmVLRGEYfadqaldvgmaevalipdSEMIGKTVREIafrtrfglnivgmkrdgkamdgsvvdeplq 375
Cdd:COG0471  159 ---------------VIREEL------------------AELGPLSRREK------------------------------ 175

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 376 lgdillvvgnwrqiallakrgrdfvvlnmpvevddaspahsqapHAIFCLVLMVALMLTDE---IPNPIAAIIACLLMGK 452
Cdd:COG0471  176 --------------------------------------------IALAIFALTVLLWITGSlhgIPIAVVALLGAVLLLL 211

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 453 FRCINAESAYKAIHWPSIILIVGMMPFALALQKTGGVDLVVKGLMDVAGGEGPYLMLGCLFMMCAAIGLFISNTATAVLM 532
Cdd:COG0471  212 TGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPLLGGLSPLLLLLLLALLTLLLTEFASNTATAALL 291

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 839495802 533 APIALAAAKSMGVSPYPFAMVVAMAASAAFMTPVSSPVNTLVLGPGKYSFSDFVKIGVPFTILVMVVCVLLIPVLFPF 610
Cdd:COG0471  292 LPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWPL 369
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 9-194 4.79e-55

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 191.26  E-value: 4.79e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802   9 LSLLAIAVVLFATGKVRMDAIALMVIVAFVLSGTLTLNEAFSGFSDPNVILIAALFIIGDGLVRTGVATKMGAWLVSVAG 88
Cdd:cd01115    1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802  89 NSETKMLIYLMLTVAGLGAFMSSTGVVAIFIPVVLSVSARMNTSPSRLMMPLSFAGLISGMMTLVATPPNLVVNSELLRE 168
Cdd:cd01115   81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSRLLMPLAFAASIGGMLTLIGTPPNLVASGYLESL 160

                        170       180
                 ....*....|....*....|....*.
gi 839495802 169 GLHGFSFFSVTPIGLVVLILGIVYML 194
Cdd:cd01115  161 GGQGFSFFEFTPIGLPLLIIGLLYLW 186
CitMHS pfam03600
Citrate transporter;
16-218 4.98e-40

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 149.38  E-value: 4.98e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802   16 VVLFATGKVRMDAIALMVIVAFVLSGTLTLNEAFSGFSDPNVILIAALFIIGDGLVRTGVATKMGAWLVSVAGNSETKML 95
Cdd:pfam03600   1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802   96 IYLMLTVAGLGAFMSSTGVVAIFIPVVLSVSARMNTSPSRLMMPLSFAGLISGMMTLVATPPNLVVNSELLREGLHgFSF 175
Cdd:pfam03600  81 VALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASALGLSFGD-FGF 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 839495802  176 FSVTPIGLVVLILGIVYMLAVRFMLKTDNGDSARDGRKRSTFR 218
Cdd:pfam03600 160 FMFPPVGVALLLVGLLPLLLIFRKLLPVRKEEEAELEELRKRA 202
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 9-188 9.09e-14

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 73.53  E-value: 9.09e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802    9 LSLLAIAVVLFATGKVRMDAIALMVI-VAFVLSGTLTLN---EAFSGFSDPNVILIAALFIIGDGLVRTGVATKMGAWLV 84
Cdd:TIGR00785  14 LAIFVAAIVGWILEPLPLPVTALLAIpIIAVLLGVLSAFkfkNALSGFADPTIWLFFGAFILATALVKTGLGKRIAYKLV 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802   85 SVAGNSETKM-LIYLMLTVAGLGAFMSSTGVV-AIFIPVVLSVSARMNTSPSR--------LMMPLSFAGLISGMMTLVA 154
Cdd:TIGR00785  94 GKMGGTTLGLgYFLVFLETLLAPMWPSNTARAgGILLPIIKSLLPLLGSKPEKsprkigkyLMLGIAYSASIGSSGFLTG 173

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 839495802  155 TPPNLVVNSELLREGLHGFSFFS----VTPIGLVVLIL 188
Cdd:TIGR00785 174 SAPNALAAGILSKILGIQISWGDwflaGLPLGIILLLL 211
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 303-395 8.41e-13

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 66.10  E-value: 8.41e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 303 GEQMLEPMVLRGEYFADQALDVGMAEVALIPDSEMIGKTVREIAFRTRFGLNIVGMKRDGKAMDGSVVDEPLQLGDILLV 382
Cdd:COG0490   47 LLLLGELLRLLTRLLIELVLLLAIEEVKVPPGSPLVGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVV 126

                         90
                 ....*....|...
gi 839495802 383 VGNWRQIALLAKR 395
Cdd:COG0490  127 VGTREQLERLEEL 139
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 326-394 1.21e-11

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 60.32  E-value: 1.21e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 839495802  326 MAEVALIPDSEMIGKTVREIAFRTRFGLNIVGMKRDGKAMDGSvVDEPLQLGDILLVVGNWRQIALLAK 394
Cdd:pfam02080   1 LVEVTVPENSPLVGKTLKELNLPERFGVRIVAIRRGGRLIIPS-GDTVLEAGDRLLVIGTPDDLAALRE 68
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 159-289 8.79e-06

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 45.68  E-value: 8.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 159 LVVNSELLREGLHGFSFFSVTPIGLVVLILGIVYMLAVRFMLktDNGDSARDGRKRSTFRDLIREYHLTgRARRLAIRPG 238
Cdd:COG0490    2 ALALLLLLIILLLLLALAALLVAIVIVGVLGLILRGLLLLEL--ALLLLLLGELLRLLTRLLIELVLLL-AIEEVKVPPG 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 839495802 239 SPMIGQRLDDLKLRERYCANVIGVerwRRFRRVIVNVNGVSEFRARDVLLI 289
Cdd:COG0490   79 SPLVGKTLGELNLRQRTGVTVVAI---RRGGEVILSPGPDTVLEAGDTLVV 126
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 231-297 1.27e-04

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 40.29  E-value: 1.27e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 839495802  231 RRLAIRPGSPMIGQRLDDLKLRERYCANVIGVERWRRfrrvIVNVNGVSEFRARDVLLIDMSASDVD 297
Cdd:pfam02080   2 VEVTVPENSPLVGKTLKELNLPERFGVRIVAIRRGGR----LIIPSGDTVLEAGDRLLVIGTPDDLA 64
trkA PRK09496
Trk system potassium transporter TrkA;
315-395 9.11e-03

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 38.95  E-value: 9.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 315 EYFADQAldVGMAEVALIPDSEMIGKTVREIAFRTR-FGLNIVGMKRDGKAM--DGSVVdepLQLGDILLVVGNWRQIAL 391
Cdd:PRK09496 145 EEFADGR--VQLVEVKVYEGSPLVGKPLSDLREHFPdIDVRVVAIFRGGRLIipRGDTV---IEAGDEVYFIGAREHIRA 219


                 ....
gi 839495802 392 LAKR 395
Cdd:PRK09496 220 VMSE 223
 
Name Accession Description Interval E-value
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
61-610 2.21e-62

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 210.40  E-value: 2.21e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802  61 AALFIIGDGLVRTGVATKMGAWLVSVAGNSETKMLIYLMLTVAGLGAFMSSTGVVAIFIPVVLSVSARM-----NTSPSR 135
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALgsekrSKFGSA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 136 LMMPLSFAGLISGMMTLVATPPNLVVNSELLREGLHGFSFFSVTPIGLVVLILGIVYMLAVRfmlktdngdsardgrkrs 215
Cdd:COG0471   81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIPISFFEWMLVGLPVALVGLLLLWLVL------------------ 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 216 tfrdlireyhltgrarrlairpgspmigqrlddlklrerycanvigverWRRFRRVIVNVNGVSEfrardvllidmsasd 295
Cdd:COG0471  143 -------------------------------------------------YRLLPPEIKEVPGSKE--------------- 158

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 296 vdlrqfcgeqmlepmVLRGEYfadqaldvgmaevalipdSEMIGKTVREIafrtrfglnivgmkrdgkamdgsvvdeplq 375
Cdd:COG0471  159 ---------------VIREEL------------------AELGPLSRREK------------------------------ 175

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 376 lgdillvvgnwrqiallakrgrdfvvlnmpvevddaspahsqapHAIFCLVLMVALMLTDE---IPNPIAAIIACLLMGK 452
Cdd:COG0471  176 --------------------------------------------IALAIFALTVLLWITGSlhgIPIAVVALLGAVLLLL 211

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 453 FRCINAESAYKAIHWPSIILIVGMMPFALALQKTGGVDLVVKGLMDVAGGEGPYLMLGCLFMMCAAIGLFISNTATAVLM 532
Cdd:COG0471  212 TGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPLLGGLSPLLLLLLLALLTLLLTEFASNTATAALL 291

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 839495802 533 APIALAAAKSMGVSPYPFAMVVAMAASAAFMTPVSSPVNTLVLGPGKYSFSDFVKIGVPFTILVMVVCVLLIPVLFPF 610
Cdd:COG0471  292 LPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWPL 369
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 9-194 4.79e-55

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 191.26  E-value: 4.79e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802   9 LSLLAIAVVLFATGKVRMDAIALMVIVAFVLSGTLTLNEAFSGFSDPNVILIAALFIIGDGLVRTGVATKMGAWLVSVAG 88
Cdd:cd01115    1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802  89 NSETKMLIYLMLTVAGLGAFMSSTGVVAIFIPVVLSVSARMNTSPSRLMMPLSFAGLISGMMTLVATPPNLVVNSELLRE 168
Cdd:cd01115   81 KGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSRLLMPLAFAASIGGMLTLIGTPPNLVASGYLESL 160

                        170       180
                 ....*....|....*....|....*.
gi 839495802 169 GLHGFSFFSVTPIGLVVLILGIVYML 194
Cdd:cd01115  161 GGQGFSFFEFTPIGLPLLIIGLLYLW 186
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 418-608 7.39e-46

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 166.61  E-value: 7.39e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 418 APHAIFCLVLMVALMLTDEIPNPIAAIIACLLMGK---FRCINAESAYKAIHWPSIILIVGMMPFALALQKTGGVDLVVK 494
Cdd:cd01115  189 FRLAVLIITIVLLAALAAITGLLPVSVAIAIGAIVlvfGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAE 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 495 GLMDVAGGEGPYLMLGCLFMMCAAIGLFISNTATAVLMAPIALAAAKSMGVSPYPFAMVVAMAASAAFMTPVSSPVNTLV 574
Cdd:cd01115  269 ALISLLGGLPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIV 348

                        170       180       190
                 ....*....|....*....|....*....|....
gi 839495802 575 LGPGKYSFSDFVKIGVPFTILVMVVCVLLIPVLF 608
Cdd:cd01115  349 LGPGGYKFSDFAKVGLPLSILSLVVSVTMIPLIW 382
CitMHS pfam03600
Citrate transporter;
16-218 4.98e-40

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 149.38  E-value: 4.98e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802   16 VVLFATGKVRMDAIALMVIVAFVLSGTLTLNEAFSGFSDPNVILIAALFIIGDGLVRTGVATKMGAWLVSVAGNSETKML 95
Cdd:pfam03600   1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802   96 IYLMLTVAGLGAFMSSTGVVAIFIPVVLSVSARMNTSPSRLMMPLSFAGLISGMMTLVATPPNLVVNSELLREGLHgFSF 175
Cdd:pfam03600  81 VALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASALGLSFGD-FGF 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 839495802  176 FSVTPIGLVVLILGIVYMLAVRFMLKTDNGDSARDGRKRSTFR 218
Cdd:pfam03600 160 FMFPPVGVALLLVGLLPLLLIFRKLLPVRKEEEAELEELRKRA 202
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 17-604 4.43e-33

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 131.22  E-value: 4.43e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802  17 VLFATGKVRMDAIALMVIVAFVLSGTLTLNEAFSGFSDPNVILIAALFIIGDGLVRTGVATKMGAWLVSVAGNSETKMLI 96
Cdd:cd00625    2 VLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGSRRLLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802  97 yLMLTVAGLGAFMSSTGVVAIFIPVVLSVSARMNTSP-SRLMMPLSFAGLISGMMTLVATPPNLVVNSELLREGLHGFSF 175
Cdd:cd00625   82 -LMLLTAALSAFFSNDATAVLLTPIVLALLRKLGLSPpVPLLLALAFAANIGGAATPIGNPPNLIIASLSGLGFLDFLAF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 176 FSVTPIGLVVLILGIVYMLAVRFMLKTDNgdsardgrkrstfrdlireyhltgrarrlairpgspmigqrlddlklrery 255
Cdd:cd00625  161 MAPPALGLLLLLLGLLYLLFRKKLLLPDE--------------------------------------------------- 189

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 256 canvigverwrrfrrvivnvngvsefrardvllidmsasdvdlrqfcgeqmlepmvlrgeyfadqaldvgmaevaliPDS 335
Cdd:cd00625  190 -----------------------------------------------------------------------------DKL 192

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 336 EMIGKTVREIAFRTRFGLnivgmkrdgkamdgsvvdeplqlgdillvvgnwrqiallakrgrdfvvlnmpvevddaspah 415
Cdd:cd00625  193 TVLAEPLPARPLLKKFLL-------------------------------------------------------------- 210

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 416 sqapHAIFCLVLMVALMLTDEIPNPIAAIIAC-LLMGKFRCINAESAYKAIHWPSIILIVGMMPFALALQKTGGVDLVVK 494
Cdd:cd00625  211 ----LALLLLLLFVLLFFFLIPLGLIALLGALlLLLLLVRGLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAE 286

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 495 GLMDVAGGeGPYLMLGCLFMMCAAIGLFISNTATAVLMAPIALAAAK-----SMGVSPYPFAMVVAMAASAAFMTPVSSP 569
Cdd:cd00625  287 LLVALVGL-PPLAALLLIGLLSALLSNFISNVPTVALLLPIAASLAPpepawLALALGSTLGGNLTLIGSLANLIPLGAA 365

                        570       580       590
                 ....*....|....*....|....*....|....*
gi 839495802 570 VNTLVlgpgKYSFSDFVKIGVPFTILVMVVCVLLI 604
Cdd:cd00625  366 ENAGV----GISFGEFLKVGLPLTLLSLVVSLLYL 396
CitMHS pfam03600
Citrate transporter;
391-547 2.81e-19

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 89.29  E-value: 2.81e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802  391 LLAKRGRDFVVLNMPVEVDDASPAHSQAPHAIFCLVLMVALMLTDEIPNPIAAIIACLLMGKFRCINAESAYKAIHWPSI 470
Cdd:pfam03600 178 LLIFRKLLPVRKEEEAELEELRKRAIKDKLLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTL 257

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 839495802  471 ILIVGMMPFALALQKTGGVDLVVKGLMDVAggeGPYLMLGCLFMMCAAIGLFISNTATAVLMAPIALAAAKSMGVSP 547
Cdd:pfam03600 258 LFFAGLFILVGALEKTGLADALADALGGLS---GLLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGD 331
CitMHS pfam03600
Citrate transporter;
429-608 2.54e-18

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 86.60  E-value: 2.54e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802  429 VALMLTDEIPNPIAAIIACLLMGKFRCINAESAYKAIHWPSIILIVGMMPFALALQKTGGVDLVVKGLMDVAGGeGPYLM 508
Cdd:pfam03600   1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGG-KPRRL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802  509 LGCLFMMCAAIGLFISNTATAVLMAPIALAAAKSMGVSPYPFAMVVAMAASAAF-MTPVSSPVNTLVLGPGKYSFSDFVK 587
Cdd:pfam03600  80 LVALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGtATPIGDPPNIIIASALGLSFGDFGF 159

                         170       180
                  ....*....|....*....|.
gi 839495802  588 IGVPFTILVMVVCVLLIPVLF 608
Cdd:pfam03600 160 FMFPPVGVALLLVGLLPLLLI 180
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
1-196 3.56e-18

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 86.36  E-value: 3.56e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802   1 MNGELIWVLSLLAIAVVLFATG---KVRMDAIALMVIVAFVLSGTLTLNEAFSGFSDPNVILIAALFIIGDGLVRTGVAT 77
Cdd:COG0471  170 LSRREKIALAIFALTVLLWITGslhGIPIAVVALLGAVLLLLTGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAA 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802  78 KMGAWLVSVAGN-SETKMLIYLMLTVAGLGAFMSSTGVVAIFIPVVLSVSARMNTSPSRLMMPLSFAGLiSGMMTLVATP 156
Cdd:COG0471  250 WLADALLPLLGGlSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALAVAFAAS-CAFLLPVGTP 328

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 839495802 157 PNLVVnsellrEGLHGFSFFSVTPIGLVVLILGIVYMLAV 196
Cdd:COG0471  329 PNAIV------YGSGYYKFKDFLKVGLPLNLIGLVVLLLL 362
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 430-610 1.28e-17

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 85.38  E-value: 1.28e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 430 ALMLTDEIPNPIAAIIACLLMGKFRCINAESAYKAIHWPSIILIVGMMPFALALQKTGGVDLVVKGLMDVAGGEGPYLML 509
Cdd:cd00625    2 VLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGSRRLLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 510 gcLFMMCAAIGLFISNTATAVLMAPIALAAAKSMGVSPYPFAMVVAMAASAA--FMTPVSSPVNTLVLGPGKYSFSDFVK 587
Cdd:cd00625   82 --LMLLTAALSAFFSNDATAVLLTPIVLALLRKLGLSPPVPLLLALAFAANIggAATPIGNPPNLIIASLSGLGFLDFLA 159

                        170       180
                 ....*....|....*....|...
gi 839495802 588 IGVPFTILVMVVCVLLIPVLFPF 610
Cdd:cd00625  160 FMAPPALGLLLLLLGLLYLLFRK 182
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
421-609 9.49e-17

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 82.87  E-value: 9.49e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 421 AIFCLVLMVALMLTDEIPNPIAAIIACLLMGKFRCINAESAYKAIHWPSIILIVGMMPFALALQKTGGVDLVVKGLMDVA 500
Cdd:COG1055    7 AIFVLTYLLIILEPRGLNRAVAALLGAALLLLLGVVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIKLARRA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 501 GGEgPYLMLGCLFMMCAAIGLFISNTATAVLMAPIALAAAKSMGVSPYPFAMVVAMAA-SAAFMTPVSSPVNTLVLGPGK 579
Cdd:COG1055   87 KGS-PRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPVPFLIAIVFAAnIGGAATPIGNPTNIMIASAGG 165

                        170       180       190
                 ....*....|....*....|....*....|
gi 839495802 580 YSFSDFVKIGVPFTILVMVVCVLLIPVLFP 609
Cdd:COG1055  166 LSFLDFLANLFPPSLVSLLVTLLVLYLLFR 195
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
6-193 1.06e-14

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 76.32  E-value: 1.06e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802   6 IWVLSLLAIAVVLFATGKVRMD--AIALMVIVAFVLSGTLTLNEAFSGFsDPNVI-LIAALFIIGDGLVRTGVATKMGAW 82
Cdd:COG1055    3 ILALAIFVLTYLLIILEPRGLNraVAALLGAALLLLLGVVSLEDALEAI-DWNTIlFLLGMMIIVAILDESGFFEWLAIK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802  83 LVSVAGNSETKMLIYLMLTVAGLGAFMSSTGVVAIFIPVVLSVSARMNTSPSRLMMPLSFAGLISGMMTLVATPPNLVVN 162
Cdd:COG1055   82 LARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPVPFLIAIVFAANIGGAATPIGNPTNIMIA 161

                        170       180       190
                 ....*....|....*....|....*....|..
gi 839495802 163 SellREGLHGFSFFSV-TPIGLVVLILGIVYM 193
Cdd:COG1055  162 S---AGGLSFLDFLANlFPPSLVSLLVTLLVL 190
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 425-610 6.95e-14

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 73.77  E-value: 6.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 425 LVLMVALMLTDEIPNPIAAIIACLLMGKFRCINAESAYKAIHWPSIILIVGMMPFALALQKTGGVDLVVKGLMDVAGGEG 504
Cdd:cd01115    4 LVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 505 PYLMLGcLFMMCAAIGLFISNTATAVLMAPIALAAAKSMGVSPYP-FAMVVAMAASAAFMTPVSSPVNTLVLGPGKYSFS 583
Cdd:cd01115   84 RRLLLL-LMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSRlLMPLAFAASIGGMLTLIGTPPNLVASGYLESLGG 162

                        170       180
                 ....*....|....*....|....*....
gi 839495802 584 DFVKIGV--PFTILVMVVCVLLIPVLFPF 610
Cdd:cd01115  163 QGFSFFEftPIGLPLLIIGLLYLWFIFRL 191
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 9-188 9.09e-14

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 73.53  E-value: 9.09e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802    9 LSLLAIAVVLFATGKVRMDAIALMVI-VAFVLSGTLTLN---EAFSGFSDPNVILIAALFIIGDGLVRTGVATKMGAWLV 84
Cdd:TIGR00785  14 LAIFVAAIVGWILEPLPLPVTALLAIpIIAVLLGVLSAFkfkNALSGFADPTIWLFFGAFILATALVKTGLGKRIAYKLV 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802   85 SVAGNSETKM-LIYLMLTVAGLGAFMSSTGVV-AIFIPVVLSVSARMNTSPSR--------LMMPLSFAGLISGMMTLVA 154
Cdd:TIGR00785  94 GKMGGTTLGLgYFLVFLETLLAPMWPSNTARAgGILLPIIKSLLPLLGSKPEKsprkigkyLMLGIAYSASIGSSGFLTG 173

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 839495802  155 TPPNLVVNSELLREGLHGFSFFS----VTPIGLVVLIL 188
Cdd:TIGR00785 174 SAPNALAAGILSKILGIQISWGDwflaGLPLGIILLLL 211
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 303-395 8.41e-13

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 66.10  E-value: 8.41e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 303 GEQMLEPMVLRGEYFADQALDVGMAEVALIPDSEMIGKTVREIAFRTRFGLNIVGMKRDGKAMDGSVVDEPLQLGDILLV 382
Cdd:COG0490   47 LLLLGELLRLLTRLLIELVLLLAIEEVKVPPGSPLVGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVV 126

                         90
                 ....*....|...
gi 839495802 383 VGNWRQIALLAKR 395
Cdd:COG0490  127 VGTREQLERLEEL 139
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 8-196 1.79e-12

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 69.15  E-value: 1.79e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802   8 VLSLLAIAVVLFATGKVRMDAIALMVIVAFVLSGTLTLNEAFSGFSDPNVILIAALFIIGDGLVRTGVATKMGAWLVSVA 87
Cdd:cd01115  195 IITIVLLAALAAITGLLPVSVAIAIGAIVLVFGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISLL 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802  88 GN-SETKMLIYLMLTVAGLGAFMSSTGVVAIFIPVVLSVSARMNTSPSRLMMPLSFAGlISGMMTLVATPPNLVVNSEll 166
Cdd:cd01115  275 GGlPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGA-SCAFMLPVGTPPNAIVLGP-- 351

                        170       180       190
                 ....*....|....*....|....*....|
gi 839495802 167 reglHGFSFFSVTPIGLVVLILGIVYMLAV 196
Cdd:cd01115  352 ----GGYKFSDFAKVGLPLSILSLVVSVTM 377
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 5-191 2.54e-12

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 68.82  E-value: 2.54e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802   5 LIWVLSLLAIAVVLFATGKVRMDAIALMVIVAFVLSGTLTLNEAFSGFSDPNVILIAALFIIGDGLVRTGVATKMGAWLV 84
Cdd:cd00625  210 LLALLLLLLFVLLFFFLIPLGLIALLGALLLLLLLVRGLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLV 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802  85 SVAGNSETKMLIYLMLTVAGLGAFMSSTGVVAIFIPVVLSVSArmntsPSRLMMPLSFAGLISGMMTLVATPPNLVVNSE 164
Cdd:cd00625  290 ALVGLPPLAALLLIGLLSALLSNFISNVPTVALLLPIAASLAP-----PEPAWLALALGSTLGGNLTLIGSLANLIPLGA 364

                        170       180
                 ....*....|....*....|....*..
gi 839495802 165 LLREGlHGFSFFSVTPIGLVVLILGIV 191
Cdd:cd00625  365 AENAG-VGISFGEFLKVGLPLTLLSLV 390
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 326-394 1.21e-11

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 60.32  E-value: 1.21e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 839495802  326 MAEVALIPDSEMIGKTVREIAFRTRFGLNIVGMKRDGKAMDGSvVDEPLQLGDILLVVGNWRQIALLAK 394
Cdd:pfam02080   1 LVEVTVPENSPLVGKTLKELNLPERFGVRIVAIRRGGRLIIPS-GDTVLEAGDRLLVIGTPDDLAALRE 68
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 425-608 1.68e-11

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 66.51  E-value: 1.68e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 425 LVLMVALMLTDEIPNPIAAIIACLLMGKFRCINAESAYKAIH----WPSIILIVGMMPFALALQKTGGVDLVVKGLMDVA 500
Cdd:cd01116    1 FIITYALIIFEKVHRTVAALAGALWLVILGLATLSPDLETIVswvdWETLALLLGMMIIVSILSETGVFEYLAIWAVKIS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 501 GGEgPYLMLGCLFMMCAAIGLFISNTATAVLMAPIALAAAKSMGVSPYPFAMVVAMAASAAFM-TPVSSPVNTLVLGPGK 579
Cdd:cd01116   81 KGR-PWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAANIGGAaTLIGDPPNIMIGSAAG 159

                        170       180
                 ....*....|....*....|....*....
gi 839495802 580 YSFSDFVKIGVPFTILVMVVCVLLIPVLF 608
Cdd:cd01116  160 LTFNDFLLHMLPSVVLALVVTFILLYFLY 188
YbiR_permease cd01117
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ...
 18-208 2.01e-11

Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.


Pssm-ID: 238537 [Multi-domain]  Cd Length: 384  Bit Score: 66.15  E-value: 2.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802  18 LFATGKVRMDAIALMVIVAF--VLSGTLTLNEAFSGFSDPNVILIAALFIIGDGLVRTGVATKMGAWLVSVAGNSEtKML 95
Cdd:cd01117    3 LGRVPGLRLDRWAIALLGAAlmLLFGVISLEDAPAAIDLDTIILLFGLMVVSAALELSGFFDALGSRILVKAGSPR-RLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802  96 IYLMLTVAGLGAFMSSTGVVAIFIPVVLSVSARMNTSPSRLMMPLSFAGLISGMMTLVATPPNLVVNSElLREGLHGFSF 175
Cdd:cd01117   82 FLLVLLSGILSALLTNDTACLVFTPIVLELARVAGLPPIPLLLALATAANIGSAATPIGNPQNLLIASE-SGISFPFFLA 160

                        170       180       190
                 ....*....|....*....|....*....|...
gi 839495802 176 FSVTPIGLVVLILGIVYMLAVRFMLKTDNGDSA 208
Cdd:cd01117  161 AMAPLALLGLLLLLILLLVLFPGELKGLPLDKA 193
COG3273 COG3273
Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];
8-398 1.29e-10

Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];


Pssm-ID: 442504 [Multi-domain]  Cd Length: 387  Bit Score: 63.53  E-value: 1.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802   8 VLSLLAIAVVLFATGKVRMDAIALMVIVAFVLSGTLTLNEAFSGFSDPNVILIAALFIIGDGLVRTGVATKMGAWLVSVA 87
Cdd:COG3273   13 PVLVKLLLVEMKDTAELLIDLAYSAVLDESDALAEEVLELELRMDVLQLLARMSLLLAARALEEAELLAPVLGVVAAAVA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802  88 GNSETKMLIYLMLTVAGLGAFMSSTGVVAIFIPVVLSVSARMNTSPSRLMMPLSFAGLISGMMTLVATPPNLVVNSELLR 167
Cdd:COG3273   93 ISAAAGDIAKVVLEDIGLPEAMRAALPEAVETLVRATVAASSALAGRTLLLILLETETGVRVIAIRRGDDWLLNPGPTTI 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 168 EGLHGFSFFSVTPIGLVVLILGIVYMLAVRFMLKtdnGDSARDGRKRSTFRDLIREYHLTGRARRLAIRpgSPMIGQRLD 247
Cdd:COG3273  173 LRADDLVLLRGPEGGILEVYLAATGDLYERPRPP---EDSIVEMKNLSELAVDLAYSSVLFDSEELAEE--VRELEEEVD 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 248 DLKLRERYCANVIG--VERWRRFRRVIVNVNGVSEFRARDVLLIDMSASDVDLRQFCGEQMLEPmvlrgeyfadqalDVG 325
Cdd:COG3273  248 ALKSRLEAWVLRAArrVDDPVALRGLLHLASSTEVISDAALDIAEGVLRGLEDHPVVAEAVRES-------------DER 314

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 839495802 326 MAEVALIPDSEMIGKTVREIAFRTRFGLNIVGMKRDGKAMDGSVVDEPLQLGDILLVVGNWRQIALLAKRGRD 398
Cdd:COG3273  315 IVRVTVPPGSPLVGKTLGELKLETETGVRVIAIRRGGGWIYDPDGDTRLRAGDVLIVKGTREGLERLEELAGG 387
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 437-608 1.93e-10

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 63.13  E-value: 1.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802  437 IPNPIAAIIACLLMGKFRCINAESAYK-AIHWPSIILIVGMMPFALALQKTGGVDLVVKGLMDVAGGEGP-YLMLGCLFM 514
Cdd:TIGR00785 270 INASVVALLAVVLMLFLGIVTWKDIQKnKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSPtIAVLVLVVL 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802  515 MCAAIGLFISNTATAVLMAPIALAAAKSMGVSPYPFAMVVAMAA-SAAFMTPVSSPVNTLVLGPGKYSFSDFVKIGVPFT 593
Cdd:TIGR00785 350 FYIILYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSAsLMGFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIG 429

                         170
                  ....*....|....*
gi 839495802  594 ILVMVVCVLLIPVLF 608
Cdd:TIGR00785 430 IVGLIVLLLVGTLWW 444
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
6-191 2.71e-10

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 62.84  E-value: 2.71e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802   6 IWVLSLLAIAVVLFATGKVRMDAIALMVIVAFVLSGTLTLNEAFSGFSDPNVILIAALFIIGDGLVRTGVATKMGAWLVS 85
Cdd:COG1055  222 LLVLALLLVGFVLHSFLGLPPALIALLGAAVLLLLARVDVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLAS 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802  86 VAGNSETKMLIYLMLTVAGLGAFMSSTGVVAIFIPVVLSVSARMNTSPsrLMMPLSFAGLISGMMTLVATPPNLVVnSEL 165
Cdd:COG1055  302 LTGGNLLLAALLILWLSAILSAVVDNVPLVAALLPLIPDLGATGNPEP--LWLALALGATLGGNLTPIGSAANVIV-LGI 378

                        170       180
                 ....*....|....*....|....*.
gi 839495802 166 LREGLHGFSFFSVTPIGLVVLILGIV 191
Cdd:COG1055  379 AEKKGIKISFGEFLKVGLPLTLLTLL 404
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 9-161 4.81e-10

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 61.98  E-value: 4.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802    9 LSLLAIAVVLFATGK---VRMDAIALMVIVAFVLSGTLTLNEAFSGFSDPNV-ILIAALFIIGDGLVRTGVATKMGAWLV 84
Cdd:TIGR00785 252 LGIFLLALLLWIFGGslgINASVVALLAVVLMLFLGIVTWKDIQKNKVAWNTlILFGGLIGLAGGLKKSGFIKWFSEKLV 331

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 839495802   85 SVAGNSETKMLI--YLMLTVAGLGAFMSSTGVVAIFIPVVLSVSARMNTSPSRLMMPLSFAGLISGMMTLVATPPNLVV 161
Cdd:TIGR00785 332 GILDGLSPTIAVlvLVVLFYIILYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMGFLTPYATPPNAIA 410
YbiR_permease cd01117
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ...
 441-610 5.63e-10

Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.


Pssm-ID: 238537 [Multi-domain]  Cd Length: 384  Bit Score: 61.52  E-value: 5.63e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 441 IAAIIACLLMGkFRCINAESAYKAIHWPSIILIVGMMPFALALQKTGGVDLVVKGLMDVAGGEgpylmLGCLFMMCAAIG 520
Cdd:cd01117   16 IALLGAALMLL-FGVISLEDAPAAIDLDTIILLFGLMVVSAALELSGFFDALGSRILVKAGSP-----RRLLFLLVLLSG 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 521 L---FISNTATAVLMAPIALAAAKSMGVSPYPFAMVVAMAASA-AFMTPVSSPVNTLVLGPGKYSFSDFVKIGVPFTILV 596
Cdd:cd01117   90 IlsaLLTNDTACLVFTPIVLELARVAGLPPIPLLLALATAANIgSAATPIGNPQNLLIASESGISFPFFLAAMAPLALLG 169

                        170
                 ....*....|....
gi 839495802 597 MVVCVLLIPVLFPF 610
Cdd:cd01117  170 LLLLLILLLVLFPG 183
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 5-194 1.62e-09

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 60.34  E-value: 1.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802   5 LIWVLSLLAIAVVLFATG---KVRMDAIALM-VIVAFVLSGTLTLNEAFSGFSDPNVILIAALFIIGDGLVRTGVATKMG 80
Cdd:cd01116  217 LLKSLTILTLVIIGFVLHsplGVSLGWIALLgALLLLLLADKLDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIA 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802  81 AWLVSVAGNSETKMLIYLMLTVAGLGAFMSSTGVVAIFIPVVLSVSARMNTSPSRLMMPLSFAGLISGMMTLVATPPNLV 160
Cdd:cd01116  297 ELLVGVILGRIAVAVILILWISALLSAFIDNIPVTATMIPIVKDLASQLGIPLLPLWWALALGACLGGNGTLIGASANVV 376

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 839495802 161 VNSELLREGlHGFSFFSVTPIGLVV----LILGIVYML 194
Cdd:cd01116  377 AAGIAEQHG-YKISFWEFLKVGFPImlvsLILATVYLL 413
CitMHS pfam03600
Citrate transporter;
7-133 6.50e-08

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 55.01  E-value: 6.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802    7 WVLSLLAIAVVLFATGKVRMDAIALMVIVAFVLSGTLTLNEAFSGFSDPNVILIAALFIIGDGLVRTGVATKMGAWLVSV 86
Cdd:pfam03600 207 LLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGL 286

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 839495802   87 AGNseTKMLIYLMLTVAGLGAFMSSTGVVAIFIPVVLSVSARMNTSP 133
Cdd:pfam03600 287 SGL--LVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGD 331
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 416-609 6.82e-08

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 55.04  E-value: 6.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802  416 SQAPHAIFCLVLMVALMLTDEIPNPIAAIIACLLM----GKFRCINAESAYKAIHWPSIILIVGMMPFALALQKTGGVDL 491
Cdd:TIGR00785   8 SGAWLLLAIFVAAIVGWILEPLPLPVTALLAIPIIavllGVLSAFKFKNALSGFADPTIWLFFGAFILATALVKTGLGKR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802  492 VVKGLMDVAGGEGPYLMLGCLFMMCAAIGLFISNTA-TAVLMAPIALAAAKSMGVSP---------YPFAMVVAMAASAA 561
Cdd:TIGR00785  88 IAYKLVGKMGGTTLGLGYFLVFLETLLAPMWPSNTArAGGILLPIIKSLLPLLGSKPeksprkigkYLMLGIAYSASIGS 167

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 839495802  562 FMTPVSSPVNTLVLG------PGKYSFSDFVKIGVPFTILVMVVCVLLIPVLFP 609
Cdd:TIGR00785 168 SGFLTGSAPNALAAGilskilGIQISWGDWFLAGLPLGIILLLLVPLLLYVLFP 221
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 28-196 7.45e-08

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 54.95  E-value: 7.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802  28 AIALMVIVAFVLSGTLTLNEAFSgFSDPNVI-LIAALFIIGDGLVRTGVATKMGAWLVSVAGNSETKMLIYLMLTVAGLG 106
Cdd:cd01116   21 AGALWLVILGLATLSPDLETIVS-WVDWETLaLLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLLLLLGLLTAFLS 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 107 AFMSSTGVVAIFIPVVLSVSARMNTSPSRLMMPLSFAGLISGMMTLVATPPNLVVNSellREGLHGFSFFSVT-PIGLVV 185
Cdd:cd01116  100 AFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAANIGGAATLIGDPPNIMIGS---AAGLTFNDFLLHMlPSVVLA 176

                        170
                 ....*....|.
gi 839495802 186 LILGIVYMLAV 196
Cdd:cd01116  177 LVVTFILLYFL 187
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 9-160 3.27e-07

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 53.14  E-value: 3.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802    9 LSLLAIAVVLFATGKVRMDAIALMVIVAF-VLSGTLT---LNEAFSGFSDPNVILIAALFIIGDGLVRTGVATKMGAWLV 84
Cdd:pfam00939  34 FAIFIATIVGWILEPLPMAVIALFAISLSaILIGTLLakaLSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLV 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802   85 SVAGNSETKMLIYLMLTVAGLGAFMSSTGV--VAIFIPVVLSVSARMNTSP---------SRLMMPLSFAGLISGMMTLV 153
Cdd:pfam00939 114 KKMGKRTLGLGYGLVFSDLLLAPATPSNTAraGGIVFPIIMSLPPAFGSDPekgserrigAYLMWTVYQSTSITSAMFLT 193


                  ....*..
gi 839495802  154 ATPPNLV 160
Cdd:pfam00939 194 AMAPNLL 200
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
422-604 1.64e-06

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 50.90  E-value: 1.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 422 IFCLVLMVALMLTDEIPNPIA--AIIACLLMGKFRCINAESAYKAIHWPSIILIVGMMPFALALQKTGGVDLVVKGLMDV 499
Cdd:COG1055  223 LVLALLLVGFVLHSFLGLPPAliALLGAAVLLLLARVDVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASL 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 500 AGGEGPYLMLGCLFMMcAAIGLFISNTATAVLMAPIAlaaaKSMGVSPYPFAMVVAMAASAAF---MTPVSSPVNTLVLG 576
Cdd:COG1055  303 TGGNLLLAALLILWLS-AILSAVVDNVPLVAALLPLI----PDLGATGNPEPLWLALALGATLggnLTPIGSAANVIVLG 377

                        170       180       190
                 ....*....|....*....|....*....|...
gi 839495802 577 -----PGKYSFSDFVKIGVPFTILVMVVCVLLI 604
Cdd:COG1055  378 iaekkGIKISFGEFLKVGLPLTLLTLLIALLYL 410
ArsB_permease cd01118
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ...
 421-608 5.12e-06

Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.


Pssm-ID: 238538 [Multi-domain]  Cd Length: 416  Bit Score: 49.19  E-value: 5.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 421 AIFCLVLMVALMLTDEIPNPIAAIIACLLMGKFRCINAESAYKAIH--WPSIILIVGMMPFALALQKTGGVDLVVKGLMD 498
Cdd:cd01118    4 AIFVLTLVLVIWRPFGLPEAVWAVLGAVIALILGLVSPHDALEVWGivWDVTLTLIGVILLSLLLDEEGFFEWVAALAAR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 499 VAGGEGPYLMLGcLFMMCAAIGLFISNTATAVLMAPIALAAAKSMGVSPY---PFAMVVAMAA-SAAFMTPVSSPVNTLV 574
Cdd:cd01118   84 WARGSGRKLFTL-IVLLGAAVTAFFANDGTALILTPIVIALLRALGAKKNrtlPFLYACAFIAdAASLPLPISNLVNIVT 162

                        170       180       190
                 ....*....|....*....|....*....|....
gi 839495802 575 LGPGKYSFSDFVKIGVPFTILVMVVCVLLIPVLF 608
Cdd:cd01118  163 AGYFGIGFTEYAALMFLPSIVSILATYVVLYLFF 196
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 323-381 8.43e-06

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 48.14  E-value: 8.43e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 839495802 323 DVGMAEVALIPDSEMIGKTVREIAFRTRFGLNIVGMKRDGKAM--DGsvvDEPLQLGDILL 381
Cdd:COG0569  239 DAEIVEVTVPEGSPLVGKTLKELDLRERYGVTVVAIKRGGEVIipSG---DTVLEAGDELI 296
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 159-289 8.79e-06

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 45.68  E-value: 8.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 159 LVVNSELLREGLHGFSFFSVTPIGLVVLILGIVYMLAVRFMLktDNGDSARDGRKRSTFRDLIREYHLTgRARRLAIRPG 238
Cdd:COG0490    2 ALALLLLLIILLLLLALAALLVAIVIVGVLGLILRGLLLLEL--ALLLLLLGELLRLLTRLLIELVLLL-AIEEVKVPPG 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 839495802 239 SPMIGQRLDDLKLRERYCANVIGVerwRRFRRVIVNVNGVSEFRARDVLLI 289
Cdd:COG0490   79 SPLVGKTLGELNLRQRTGVTVVAI---RRGGEVILSPGPDTVLEAGDTLVV 126
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 467-604 6.34e-05

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 45.83  E-value: 6.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802  467 WPSIILIVGMMPFALALQKTGGVDLVVKGLMD-VAGGEGPYLMLGCLFMMCAAIGLFISNTATAVLMAPIALAAAKSMGV 545
Cdd:pfam00939 322 WNTLIWLGGLIMLANGLERSGFIEWLGNTLSTsLSGFSPAMAFIIILSLFYLSHYLFASATAHTAAMLPIFAAVAQAIPG 401

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 839495802  546 SPYPFAMVVAMAAS--AAFMTPVSSPVNTLVLGPGKYSFSDFVKIGVPFTILVMVVCVLLI 604
Cdd:pfam00939 402 APPLLAALLLGFAIslGGFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLG 462
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 231-297 1.27e-04

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 40.29  E-value: 1.27e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 839495802  231 RRLAIRPGSPMIGQRLDDLKLRERYCANVIGVERWRRfrrvIVNVNGVSEFRARDVLLIDMSASDVD 297
Cdd:pfam02080   2 VEVTVPENSPLVGKTLKELNLPERFGVRIVAIRRGGR----LIIPSGDTVLEAGDRLLVIGTPDDLA 64
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
 176-395 1.69e-04

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 44.34  E-value: 1.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 176 FSVT-PIGLVVLILgivYMLAVRFMLKTDNGDSARDGRKRSTFRdlirEYHLTGRARRLAirpGSPMIGQRLDDLklRER 254
Cdd:COG2985  158 YAVAyPFGVIGIIL---FVALLPKLFRIDLDAEAKKLEAGEGSA----YPPLVTRAYRVT---NPNLVGKTVAEL--EAL 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 255 YCANVIgVERWRRFRRVIVnVNGVSEFRARDVLLIDMSASDVD-LRQFCGEqmlepmvlrgEYFADQALDVGMAEV-ALI 332
Cdd:COG2985  226 LGTRVV-ISRIRRGGEIIV-PTPDTVLQEGDIVLVVGTREALEaAEALLGE----------EVDDSELLDSDLDVRrIVV 293

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 839495802 333 PDSEMIGKTVREIAFRTRFGLNIVGMKRDGKAM--DGSVVdepLQLGDILLVVGNWRQIALLAKR 395
Cdd:COG2985  294 TNKEVAGKTLGELNLRNRFGVVITRVRRGGVELpaTPDTV---LQLGDRLTVVGPKEDVERVAKL 355
ArsB_permease cd01118
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ...
 5-196 1.99e-04

Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.


Pssm-ID: 238538 [Multi-domain]  Cd Length: 416  Bit Score: 44.18  E-value: 1.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802   5 LIWVLSLLAIAVVLFATGKVRMDAIALMVIVAFVLSGTLTLNEAFSGFSD--PNVILIAALFIIGDGLVRTGVATKMGAW 82
Cdd:cd01118    1 LAIAIFVLTLVLVIWRPFGLPEAVWAVLGAVIALILGLVSPHDALEVWGIvwDVTLTLIGVILLSLLLDEEGFFEWVAAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802  83 LVSVAGNSETKMLIYLMLTVAGLGAFMSSTGVVAIFIPVVLSVSARMNTSPSRLMMPLSFAGLISGMMTLVATPPNLVvn 162
Cdd:cd01118   81 AARWARGSGRKLFTLIVLLGAAVTAFFANDGTALILTPIVIALLRALGAKKNRTLPFLYACAFIADAASLPLPISNLV-- 158

                        170       180       190
                 ....*....|....*....|....*....|....
gi 839495802 163 sELLREGLHGFSFFSVTPIGLVVLILGIVYMLAV 196
Cdd:cd01118  159 -NIVTAGYFGIGFTEYAALMFLPSIVSILATYVV 191
DctM pfam06808
Tripartite ATP-independent periplasmic transporter, DctM component; This family contains a ...
 504-610 3.13e-04

Tripartite ATP-independent periplasmic transporter, DctM component; This family contains a diverse range of predicted transporter proteins. Including the DctM subunit of the bacterial and archaeal TRAP C4-dicarboxylate transport (Dct) system permease. In general, C4-dicarboxylate transport systems allow C4-dicarboxylates like succinate, fumarate, and malate to be taken up. TRAP C4-dicarboxylate carriers are secondary carriers that use an electrochemical H+ gradient as the driving force for transport. DctM is an integral membrane protein that is one of the constituents of TRAP carriers. Note that many family members are hypothetical proteins.


Pssm-ID: 284275 [Multi-domain]  Cd Length: 413  Bit Score: 43.40  E-value: 3.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802  504 GPYLMLGCLFMMCAAIGLFISNTATAVLMAPIALAAAKSMGVSPYPFAMVVAMAASAAFMTPVSSPVNTLVLGPGKYSFS 583
Cdd:pfam06808 308 GNLLFLILVNLLCLVLGMFLDPTAAIIILVPILAPAAAQLGIDPIHFGVVIVYNGSIGLITPPVGLALFVAAGIAKVSFE 387

                          90       100
                  ....*....|....*....|....*..
gi 839495802  584 DFVKIGVPFtILVMVVCVLLIPVLFPF 610
Cdd:pfam06808 388 EVVKGVVPF-LFVLVPALVLIISVPEL 413
GntT COG2610
H+/gluconate symporter GntT or related permease, GntP/DsdX family [Carbohydrate transport and ...
 11-156 4.80e-04

H+/gluconate symporter GntT or related permease, GntP/DsdX family [Carbohydrate transport and metabolism];


Pssm-ID: 442022 [Multi-domain]  Cd Length: 440  Bit Score: 42.79  E-value: 4.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802  11 LLAIAVVLFATGKVRMDAIALMVIVAFV---LSG------TLTLNEAFSGFSDPNVILIAALFIIGDGLVRTGVATKMGA 81
Cdd:COG2610    8 LLAIALLILLIIKFKLHPFLALLLAALLvglLAGmplakiVTSIMTGFGGTLGSIGLVIGLGAMLGKLLEDSGAAERIAD 87

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 839495802  82 WLVSVAGnsETKMLIYLMLT--VAGLGAFMSStgVVAIFIPVVLSVSARMNTSPSRLMMPLSfAGLISGMMTLVATP 156
Cdd:COG2610   88 TIIKKFG--EKRAPLALVLAgfILGIPVFFDV--GFVILAPLAFSLARRAGISKLLIGLALA-AGLSTTHMLVPPTP 159
DctM pfam06808
Tripartite ATP-independent periplasmic transporter, DctM component; This family contains a ...
 28-157 6.79e-04

Tripartite ATP-independent periplasmic transporter, DctM component; This family contains a diverse range of predicted transporter proteins. Including the DctM subunit of the bacterial and archaeal TRAP C4-dicarboxylate transport (Dct) system permease. In general, C4-dicarboxylate transport systems allow C4-dicarboxylates like succinate, fumarate, and malate to be taken up. TRAP C4-dicarboxylate carriers are secondary carriers that use an electrochemical H+ gradient as the driving force for transport. DctM is an integral membrane protein that is one of the constituents of TRAP carriers. Note that many family members are hypothetical proteins.


Pssm-ID: 284275 [Multi-domain]  Cd Length: 413  Bit Score: 42.24  E-value: 6.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802   28 AIALMVIVAFVLSGTLTLNEAFSGFSDPN------VILIAALFIIGDGLVRTGVATKMGAWLVSVAGNSETkMLIYLMLT 101
Cdd:pfam06808 241 AVVYALLIGVLVYRRLTLEEVAAALLQTAkttaavLFILAAAGIFAGLLTITGVPFKLSDWLLSLGGGNLL-FLILVNLL 319

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 839495802  102 VAGLGAFMSSTGVVAIFIPVVLSVSARMNTSPSRLMMPLSFAGLISGMmtlvaTPP 157
Cdd:pfam06808 320 CLVLGMFLDPTAAIIILVPILAPAAAQLGIDPIHFGVVIVYNGSIGLI-----TPP 370
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 214-288 1.86e-03

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 40.82  E-value: 1.86e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 839495802 214 RSTFRDLIREYHLTGRARRLAIRPGSPMIGQRLDDLKLRERYCANVIGVERwrrfRRVIVNVNGVSEFRARDVLL 288
Cdd:COG0569  226 RPGVLDVLELADGDAEIVEVTVPEGSPLVGKTLKELDLRERYGVTVVAIKR----GGEVIIPSGDTVLEAGDELI 296
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 8-194 2.32e-03

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 40.82  E-value: 2.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802    8 VLSLLAIAVVLFATG-KVRMDA--IALMVIVAFVLSGTLTLNEAFSGFSDPN-VILIAALFIIGDGLVRTGVATKMGAWL 83
Cdd:pfam00939 272 LLGLFVLLLLLWIFGgSLNIDAttVAIIGLALMLLLRILDWKDIVKNKGAWNtLIWLGGLIMLANGLERSGFIEWLGNTL 351

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802   84 VSVAGNSETKMLIYLMLTVAGLG--AFMSSTGVVAIFIPVVLSVSARMNTSPSRL-MMPLSFAGLISGMMTLVATPPNLV 160
Cdd:pfam00939 352 STSLSGFSPAMAFIIILSLFYLShyLFASATAHTAAMLPIFAAVAQAIPGAPPLLaALLLGFAISLGGFLTPYGTGPGPI 431

                         170       180       190
                  ....*....|....*....|....*....|....
gi 839495802  161 VnsellreglHGFSFFSVTPIGLVVLILGIVYML 194
Cdd:pfam00939 432 Y---------FGSGYLKVKDWWRIGAILTIIGLL 456
trkA PRK09496
Trk system potassium transporter TrkA;
315-395 9.11e-03

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 38.95  E-value: 9.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839495802 315 EYFADQAldVGMAEVALIPDSEMIGKTVREIAFRTR-FGLNIVGMKRDGKAM--DGSVVdepLQLGDILLVVGNWRQIAL 391
Cdd:PRK09496 145 EEFADGR--VQLVEVKVYEGSPLVGKPLSDLREHFPdIDVRVVAIFRGGRLIipRGDTV---IEAGDEVYFIGAREHIRA 219


                 ....
gi 839495802 392 LAKR 395
Cdd:PRK09496 220 VMSE 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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