|
Name |
Accession |
Description |
Interval |
E-value |
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
166-429 |
1.81e-48 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 170.86 E-value: 1.81e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 166 CSWIAVRQVVRPFLqftravdSLDPAAHS--------PMTEKGPVEVRQAAHAFNEMQSRIQTYLRERAQILASISHDLQ 237
Cdd:PRK09467 169 GGWLFIRIQNRPLV-------ALEHAALQvgkgeippPLREYGASEVRSVTRAFNQMAAGIKQLEDDRTLLMAGVSHDLR 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 238 TPITRMKLRIEM--ADQPELRDKLLSDLDNMSRLVREGIAYARSSEslEETTLKLELNAWVNSIASDYQDIGKNVQFHAR 315
Cdd:PRK09467 242 TPLTRIRLATEMmsEEDGYLAESINKDIEECNAIIEQFIDYLRTGQ--EMPMEMADLNALLGEVIAAESGYEREIETALQ 319
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 316 NARLPIVTRPQALRRVMTNLLDNALKFGDSAV-IEIDEDERQVAIRIMDNGPGIPEAELEAVLQPFYRVETSRNREtgGT 394
Cdd:PRK09467 320 PGPIEVPMNPIAIKRALANLVVNAARYGNGWIkVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGSS--GT 397
|
250 260 270
....*....|....*....|....*....|....*
gi 838655919 395 GLGLAIAAQLTAQLDGKLHIANRAEGGLAVSVTLP 429
Cdd:PRK09467 398 GLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLP 432
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
122-431 |
1.78e-47 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 165.47 E-value: 1.78e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 122 ISHIQAHLTLRDGAPLTIDLIPRMPPVASWLPVVLVLQLLLVALCSWIAVRQVVRPFLQFTRAVDSLDPAAHSPMTEKGP 201
Cdd:COG0642 7 LLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 202 VEVRQAAHAFNEMQSRIQTYLRERAQILASISHDLQTPITRMKLRIEMA------DQPELRDKLLSDLDNMSRLVREGIA 275
Cdd:COG0642 87 LLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLleeldeEQREYLETILRSADRLLRLINDLLD 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 276 YARS-SESLEETTLKLELNAWVNSIASDYQDI--GKNVQFHAR--NARLPIVTRPQALRRVMTNLLDNALKFGDSA---V 347
Cdd:COG0642 167 LSRLeAGKLELEPEPVDLAELLEEVVELFRPLaeEKGIELELDlpDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGgtvT 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 348 IEIDEDERQVAIRIMDNGPGIPEAELEAVLQPFYRVETSRNreTGGTGLGLAIAAQLTAQLDGKLHIANRAEGGLAVSVT 427
Cdd:COG0642 247 VSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRR--GGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVT 324
|
....
gi 838655919 428 LPRG 431
Cdd:COG0642 325 LPLA 328
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
216-430 |
4.59e-47 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 166.27 E-value: 4.59e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 216 SRIQTYLRERAQILASISHDLQTPITRMKLRIEM-----ADQPELRDKLL----SDLDNMSRLVREGIAYARssesLEET 286
Cdd:COG5002 156 TELERLEQMRREFVANVSHELRTPLTSIRGYLELlldgaADDPEERREYLeiilEEAERLSRLVNDLLDLSR----LESG 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 287 TLKLE-----LNAWVNSIASDYQDIGKN----VQFHARNARLPIVTRPQALRRVMTNLLDNALKF---GDSAVIEIDEDE 354
Cdd:COG5002 232 ELKLEkepvdLAELLEEVVEELRPLAEEkgieLELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYtpeGGTITVSLREED 311
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 838655919 355 RQVAIRIMDNGPGIPEAELEAVLQPFYRVETSRNRETGGTGLGLAIAAQLTAQLDGKLHIANRAEGGLAVSVTLPR 430
Cdd:COG5002 312 DQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPL 387
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
210-430 |
5.02e-46 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 158.92 E-value: 5.02e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 210 AFNEMQSRIQTYLRERAQILASISHDLQTPITRMKLRIEM---------ADQPELRDKLLSDLDNMSRLVREGIAYARss 280
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELlldeedlspEERRELLEIIRESAERLLRLIEDLLDLSR-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 281 esLEETTLKLE-----LNAWVNSIASDYQDI----GKNVQFHARNARLPIVTRPQALRRVMTNLLDNALKFGDSA---VI 348
Cdd:COG2205 79 --LESGKLSLElepvdLAELLEEAVEELRPLaeekGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGgtiTI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 349 EIDEDERQVAIRIMDNGPGIPEAELEAVLQPFYRVETSRNreTGGTGLGLAIAAQLTAQLDGKLHIANRAEGGLAVSVTL 428
Cdd:COG2205 157 SARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRG--EGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTL 234
|
..
gi 838655919 429 PR 430
Cdd:COG2205 235 PL 236
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
192-429 |
1.76e-40 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 150.08 E-value: 1.76e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 192 AHSPMTEKGPVEVRQAAHAFNEMQSRIQTYLRERAQILASISHDLQTPITRMKL----------------RIEMADQpel 255
Cdd:PRK09470 210 RQHPELETGPQEFRQAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLatallrrrqgeskeleRIETEAQ--- 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 256 R-DKLLSDLDNMSRlvregiayarssesleeTTLKLELNAWVNSIASDYQDIGKNVQFHA--RN---------ARLPIVT 323
Cdd:PRK09470 287 RlDSMINDLLVLSR-----------------NQQKNHLERETFKANSLWSEVLEDAKFEAeqMGksltvsappGPWPING 349
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 324 RPQALRRVMTNLLDNALKFGDSAV-IEIDEDERQVAIRIMDNGPGIPEAELEAVLQPFYRVETSRNRETGGTGLGLAIAA 402
Cdd:PRK09470 350 NPNALASALENIVRNALRYSHTKIeVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVE 429
|
250 260
....*....|....*....|....*...
gi 838655919 403 QLTAQLDGKLhIANRAE-GGLAVSVTLP 429
Cdd:PRK09470 430 NAIQQHRGWV-KAEDSPlGGLRLTIWLP 456
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
210-429 |
7.15e-33 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 128.57 E-value: 7.15e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 210 AFNEMQSRIQTYLRERAQILASISHDLQTPITRMKLRIEMADQP--ELRDKLLSDLDNMSRLVREGIAYARssesLE--E 285
Cdd:PRK10604 197 AFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSDNLsaAESQALNRDIGQLEALIEELLTYAR----LDrpQ 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 286 TTLKLE---LNAWVNSIASDYQDIGKNVQFHARNAR--LPIVTRPQALRRVMTNLLDNALKFGDSAV-IEIDEDERQVAI 359
Cdd:PRK10604 273 NELHLSepdLPAWLSTHLADIQAVTPEKTVRLDTPHqgDYGALDMRLMERVLDNLLNNALRYAHSRVrVSLLLDGNQACL 352
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 360 RIMDNGPGIPEAELEAVLQPFYRVETSRNRETGGTGLGLAIAAQLTAQLDGKLHIANRAEGGLAVSVTLP 429
Cdd:PRK10604 353 IVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-429 |
1.73e-30 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 113.19 E-value: 1.73e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 328 LRRVMTNLLDNALKFGDSAV-IEIDEDERQVAIRIMDNGPGIPEAELEAVLQPFYRVETSRNRETGGTGLGLAIAAQLTA 406
Cdd:cd16949 1 LARALENVLRNALRYSPSKIlLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIE 80
|
90 100
....*....|....*....|...
gi 838655919 407 QLDGKLHIANRAEGGLAVSVTLP 429
Cdd:cd16949 81 QHGGKIKASNRKPGGLRVRIWLP 103
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
325-429 |
5.60e-30 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 111.97 E-value: 5.60e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 325 PQALRRVMTNLLDNALKFGDSAV---IEIDEDERQVAIRIMDNGPGIPEAELEAVLQPFYRVEtSRNRETGGTGLGLAIA 401
Cdd:smart00387 3 PDRLRQVLSNLLDNAIKYTPEGGritVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTD-KRSRKIGGTGLGLSIV 81
|
90 100
....*....|....*....|....*...
gi 838655919 402 AQLTAQLDGKLHIANRAEGGLAVSVTLP 429
Cdd:smart00387 82 KKLVELHGGEISVESEPGGGTTFTITLP 109
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
328-428 |
1.76e-29 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 110.39 E-value: 1.76e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 328 LRRVMTNLLDNALKFGDSA---VIEIDEDERQVAIRIMDNGPGIPEAELEAVLQPFYRVETSrnRETGGTGLGLAIAAQL 404
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGgtiEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKS--REGGGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 838655919 405 TAQLDGKLHIANRAEGGLAVSVTL 428
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
226-430 |
1.37e-28 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 116.21 E-value: 1.37e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 226 AQILASISHDLQTPIT---------RMKLRIEMADQPELRDKLLSDL----DNMSRLVREGIAYARSSE-SLEEttlkLE 291
Cdd:COG5000 202 GELARRIAHEIKNPLTpiqlsaerlRRKLADKLEEDREDLERALDTIirqvDRLKRIVDEFLDFARLPEpQLEP----VD 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 292 LNAWVNSIASDYQD--IGKNVQFHARNA--RLPIVTRPQALRRVMTNLLDNALKFGDSA---VIEIDEDERQVAIRIMDN 364
Cdd:COG5000 278 LNELLREVLALYEPalKEKDIRLELDLDpdLPEVLADRDQLEQVLINLLKNAIEAIEEGgeiEVSTRREDGRVRIEVSDN 357
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 838655919 365 GPGIPEAELEAVLQPFYrveTSRnreTGGTGLGLAIAAQLTAQLDGKLHIANRAEGGLAVSVTLPR 430
Cdd:COG5000 358 GPGIPEEVLERIFEPFF---TTK---PKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPL 417
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-429 |
2.81e-28 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 107.15 E-value: 2.81e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 328 LRRVMTNLLDNALKFGDSAV-IEIDEDERQVAIRIMDNGPGIPEAELEAVLQPFYRVETSRNreTGGTGLGLAIAAQLTA 406
Cdd:cd16950 1 LKRVLSNLVDNALRYGGGWVeVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRISD 78
|
90 100
....*....|....*....|...
gi 838655919 407 QLDGKLHIANRAEGGLAVSVTLP 429
Cdd:cd16950 79 AHGGSLTLANRAGGGLCARIELP 101
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
325-429 |
2.07e-26 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 102.45 E-value: 2.07e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 325 PQALRRVMTNLLDNALKF---GDSAVIEIDEDERqVAIRIMDNGPGIPEAELEAVLQPFYRVETsrnRETGGTGLGLAIA 401
Cdd:pfam02518 3 ELRLRQVLSNLLDNALKHaakAGEITVTLSEGGE-LTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLSIV 78
|
90 100
....*....|....*....|....*...
gi 838655919 402 AQLTAQLDGKLHIANRAEGGLAVSVTLP 429
Cdd:pfam02518 79 RKLVELLGGTITVESEPGGGTTVTLTLP 106
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
168-400 |
2.07e-25 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 107.86 E-value: 2.07e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 168 WIAVRQVVRPFLQFTRAVDSLDP---AAHSPMTEKgPVEVRQAAHAFNEMQSRIQTYLRERAQILASISHDLQTPITRMK 244
Cdd:TIGR01386 182 WWITRLGLEPLRRLSAVAARISPeslDQRLDPSRA-PAELRELAQSFNAMLGRLEDAFQRLSQFSADLAHELRTPLTNLL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 245 LRIEMA-----DQPELRDKLLSDLDN---MSRLVREGIAYARSSESLEETTL-KLELNAWVNSIASDYQDIG--KNVQFH 313
Cdd:TIGR01386 261 GQTQVAlsqprTGEEYREVLESNLEElerLSRMVSDMLFLARADNGQLALERvRLDLAAELAKVAEYFEPLAeeRGVRIR 340
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 314 AR-NARLPivTRPQALRRVMTNLLDNALKF---GDSAVIEIDEDERQVAIRIMDNGPGIPEAELEAVLQPFYRVETSRNR 389
Cdd:TIGR01386 341 VEgEGLVR--GDPQMFRRAISNLLSNALRHtpdGGTITVRIERRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSN 418
|
250
....*....|.
gi 838655919 390 ETGGTGLGLAI 400
Cdd:TIGR01386 419 SGEGTGLGLAI 429
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
203-429 |
3.39e-24 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 104.33 E-value: 3.39e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 203 EVRQAAHAFNEMQSRIQTYLRERAQILASISHDLQTPITRMKLRIEmADQPELRD-----------------KLLSDLDN 265
Cdd:PRK10549 218 ELGRLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRGELE-AIQDGVRKftpesvaslqaevgtltKLVDDLHQ 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 266 MSRLVREGIAYARSSesleettlkLELNAWVNSIASDYQDIgknvqFHARNARL--------PIVTRPQALRRVMTNLLD 337
Cdd:PRK10549 297 LSLSDEGALAYRKTP---------VDLVPLLEVAGGAFRER-----FASRGLTLqlslpdsaTVFGDPDRLMQLFNNLLE 362
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 338 NALKFGDSA---VIEIDEDERQVAIRIMDNGPGIPEAELEAVLQPFYRVETSRNRETGGTGLGLAIAAQLTAQLDGKLHI 414
Cdd:PRK10549 363 NSLRYTDSGgslHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIA 442
|
250
....*....|....*
gi 838655919 415 ANRAEGGLAVSVTLP 429
Cdd:PRK10549 443 AHSPFGGVSITVELP 457
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
202-430 |
5.79e-24 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 104.10 E-value: 5.79e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 202 VEVRQAAHAFNEMQSRIQTYLRERAQILASISHDLQTPITRMKL---RIEMADQPELRDKLLSDLD-------NMSRLVR 271
Cdd:COG4251 259 LELEELEEELEERTAELERSNEELEQFAYVASHDLREPLRKISGfsqLLEEDYGDKLDEEGREYLErirdaaeRMQALID 338
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 272 EGIAYARSSESLEETTlKLELNAWVNSIASDYQDI--GKNVQFHARNarLPIV-TRPQALRRVMTNLLDNALKF---GDS 345
Cdd:COG4251 339 DLLAYSRVGRQELEFE-PVDLNELLEEVLEDLEPRieERGAEIEVGP--LPTVrGDPTLLRQVFQNLISNAIKYsrpGEP 415
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 346 AVIEID--EDERQVAIRIMDNGPGIPEAELEAVLQPFYRVETSRNREtgGTGLGLAIAAQLTAQLDGKLHIANRAEGGLA 423
Cdd:COG4251 416 PRIEIGaeREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEYE--GTGIGLAIVKKIVERHGGRIWVESEPGEGAT 493
|
....*..
gi 838655919 424 VSVTLPR 430
Cdd:COG4251 494 FYFTLPK 500
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
107-430 |
1.49e-23 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 101.03 E-value: 1.49e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 107 LSAQYPLQFTAVPGPISHIQAHLTLRDGAPLTIDLIPRMPPVASWLPVVLVLQLLLVALCSWIAVRQVVRPFLQFTRAVD 186
Cdd:COG4191 22 LALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAAL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 187 SLDPAAHSPMTEKGPVEVRQAAHAFNEMQSR-IQTylrER----AQILASISHDLQTPITRMKLRIEMA--------DQP 253
Cdd:COG4191 102 DAEENAELEELERDITELERAEEELRELQEQlVQS---EKlaalGELAAGIAHEINNPLAAILGNAELLrrrledepDPE 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 254 ELRDKL---LSDLDNMSRLVREGIAYARSSESLEETtlkLELNAWVNSIAS------DYQDIgkNVQFHARNARLPIVTR 324
Cdd:COG4191 179 ELREALeriLEGAERAAEIVRSLRAFSRRDEEEREP---VDLNELIDEALEllrprlKARGI--EVELDLPPDLPPVLGD 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 325 PQALRRVMTNLLDNALK-FGDSA----VIEIDEDERQVAIRIMDNGPGIPEAELEAVLQPFYrveTSRnRETGGTGLGLA 399
Cdd:COG4191 254 PGQLEQVLLNLLINAIDaMEEGEggriTISTRREGDYVVISVRDNGPGIPPEVLERIFEPFF---TTK-PVGKGTGLGLS 329
|
330 340 350
....*....|....*....|....*....|.
gi 838655919 400 IAAQLTAQLDGKLHIANRAEGGLAVSVTLPR 430
Cdd:COG4191 330 ISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
328-429 |
7.63e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 92.56 E-value: 7.63e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 328 LRRVMTNLLDNALKFGDS-------AVIEIDEDERQVAIRIMDNGPGIPEAELEAVLQPFYRVETSRNRETGGTGLGLAI 400
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEgevtlrvSLEEEEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 838655919 401 AAQLTAQLDGKLHIANRAEGGLAVSVTLP 429
Cdd:cd16922 81 SKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
167-430 |
1.10e-22 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 98.50 E-value: 1.10e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 167 SWIAVRQVVRPFLQF-----TRAVDSLDP-AAHSPMTEKGPVevrqaAHAFNEMQSRIQTYLRERAQILASISHDLQTPI 240
Cdd:PRK10755 78 CFQAVRWITRPLAELqkeleARTADNLTPiAIHSSTLEIEAV-----TSALNQLVSRLTSTLDQERLFTADVAHELRTPL 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 241 TRMKLRIEMADQPELRD--KLLSDLDNMSRLVREGIAYARSSESLEE---TTLKlelnaWVNS-IASDYQDIGKNVQFHA 314
Cdd:PRK10755 153 AGIRLHLELLEKQHHIDvaPLIARLDQMMHTVEQLLQLARAGQSFSSghyQTVK-----LLEDvILPSQDELSEMLEQRQ 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 315 RNARLPIVTRPQA-------LRRVMTNLLDNALKF---GDSAVIEIDEDERQVAIRIMDNGPGIPEAELEAVLQPFYRVE 384
Cdd:PRK10755 228 QTLLLPESAADITvqgdatlLRLLLRNLVENAHRYspeGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMD 307
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 838655919 385 TsrnrETGGTGLGLAIAAQLTAQLDGKLHIANRAE-GGLAVSVTLPR 430
Cdd:PRK10755 308 S----RYGGIGLGLSIVSRITQLHHGQFFLQNRQErSGTRAWVWLPK 350
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
169-430 |
1.13e-22 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 99.85 E-value: 1.13e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 169 IAVRQVVRPFLQFTRAVDS---------LDPAAHspmtekgPVEVRQAAHAFNEMQSRIQTYLRERAQILASISHDLQTP 239
Cdd:PRK09835 204 LAVHKGHAPIRSVSRQIQNitskdldvrLDPQTV-------PIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTP 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 240 ITRMKLRIEMA-----DQPELRDKLLSDLDN---MSRLVREGIAYARS-SESLEETTLKLELNAWVNSIASDYQDIGKNV 310
Cdd:PRK09835 277 ITNLITQTEIAlsqsrSQKELEDVLYSNLEEltrMAKMVSDMLFLAQAdNNQLIPEKKMLDLADEVGKVFDFFEAWAEER 356
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 311 QFHAR-NARLPIVT-RPQALRRVMTNLLDNALKF---GDSAVIEIDEDERQVAIRIMDNGPGIPEAELEAVLQPFYRVET 385
Cdd:PRK09835 357 GVELRfVGDPCQVAgDPLMLRRAISNLLSNALRYtpaGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDP 436
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 838655919 386 SRNRETGGTGLGLAIAAQLTAQLDGKLHIANRAEGGLAVsVTLPR 430
Cdd:PRK09835 437 SRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDARGTRFV-ISLPR 480
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
176-427 |
7.94e-22 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 97.03 E-value: 7.94e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 176 RPFLQFTRAVDSLDPAAHSPMTEKG-PVEVRQAAHAFNEMQSRIQTYL-RERaQILASISHDLQTPITRMKLRIEMA--- 250
Cdd:PRK10337 187 APLKKLALALRMRDPDSETPLNATGvPSEVRPLVEALNQLFARTHAMMvRER-RFTSDAAHELRSPLAALKVQTEVAqls 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 251 -DQPELRDKLLSDL----DNMSRLVREGIAYAR--SSESLEETT---LKLELNAWVNSIASDYQDIGKNVQFHArNARlP 320
Cdd:PRK10337 266 dDDPQARKKALLQLhagiDRATRLVDQLLTLSRldSLDNLQDVAeipLEDLLQSAVMDIYHTAQQAGIDVRLTL-NAH-P 343
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 321 IVTRPQAL--RRVMTNLLDNALKFGDS-AVIEIDEDERqvAIRIMDNGPGIPEAELEAVLQPFYRvetSRNRETGGTGLG 397
Cdd:PRK10337 344 VIRTGQPLllSLLVRNLLDNAIRYSPQgSVVDVTLNAR--NFTVRDNGPGVTPEALARIGERFYR---PPGQEATGSGLG 418
|
250 260 270
....*....|....*....|....*....|.
gi 838655919 398 LAIAAQLtAQLDG-KLHIANRAEGGLAVSVT 427
Cdd:PRK10337 419 LSIVRRI-AKLHGmNVSFGNAPEGGFEAKVS 448
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
326-428 |
2.46e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 89.11 E-value: 2.46e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 326 QALRRVMTNLLDNALKFGDSAV---IEIDEDERQVAIRIMDNGPGIPEAELEAVLQPFYRVETSRNRETGGTGLGLAIAA 402
Cdd:cd16947 19 EALQRILKNLISNAIKYGSDGKflgMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGLTITK 98
|
90 100
....*....|....*....|....*.
gi 838655919 403 QLTAQLDGKLHIANRAEGGLAVSVTL 428
Cdd:cd16947 99 RLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
325-429 |
5.60e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 87.52 E-value: 5.60e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 325 PQALRRVMTNLLDNALKFGDSA-VIEIDEDERQVAIRI--MDNGPGIPEAELEAVLQPFYRVETSRNRETGGTGLGLAIA 401
Cdd:cd16946 2 RDRLQQLFVNLLENSLRYTDTGgKLRIRAAQTPQEVRLdvEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAIC 81
|
90 100
....*....|....*....|....*...
gi 838655919 402 AQLTAQLDGKLHIANRAEGGLAVSVTLP 429
Cdd:cd16946 82 HNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
303-428 |
4.57e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 85.76 E-value: 4.57e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 303 YQDIGKNVQFHA-RNARLPIvtRPQALRRVMTNLLDNALKFGDSAV-IEIDEDERQVAIRIMDNGPGIPEAELEAVLQPF 380
Cdd:cd16954 14 YQRKGVSISLDIsPELRFPG--ERNDLMELLGNLLDNACKWCLEFVeVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRG 91
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 838655919 381 YRVETSRNretgGTGLGLAIAAQLTAQLDGKLHIANRAEGGLAVSVTL 428
Cdd:cd16954 92 QRLDEQRP----GQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
166-431 |
2.29e-19 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 89.90 E-value: 2.29e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 166 CSWIavrqVVRPFLQFTRAVDSLDPAAHSPMTEKGPVEVRQAAHAFNEMQSR------IQTYLReraqilaSISHDLQTP 239
Cdd:PRK11100 202 VVWW----LNRSIRRLTRYADAVTEGKPVPLPKLGSSELRELAQALESMRVKlegkayVEQYVQ-------TLTHELKSP 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 240 ITRMK-----LRIEMAdqPELRDKLLSDLDN----MSRLVREGIAYARssesLE-----ETTLKLELNAWVNSIASDYQD 305
Cdd:PRK11100 271 LAAIRgaaelLQEDPP--PEDRARFTGNILTqsarLQQLIDRLLELAR----LEqrqelEVLEPVALAALLEELVEAREA 344
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 306 I--GKNVQFHARNARLPIVTRPQALRRVMTNLLDNALKF---GDSAVIEIDEDERQVAIRIMDNGPGIPEAELEAVLQPF 380
Cdd:PRK11100 345 QaaAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFspeGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERF 424
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 838655919 381 Y---RVETSRNretgGTGLGLAIAAQLTAQLDGKLHIANRAEGGLAVSVTLPRG 431
Cdd:PRK11100 425 YslpRPANGRK----STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRH 474
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
227-429 |
1.97e-18 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 87.09 E-value: 1.97e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 227 QILASISHDLQTPITRMK-----LRIEMADQPELRDKLLSDLDNMSRLVREGIAYAR-SSESLEETTLKLELNAWVNSIA 300
Cdd:COG5805 289 QLAAGIAHEIRNPLTSIKgflqlLQPGIEDKEEYFDIMLSELDRIESIISEFLALAKpQAVNKEKENINELIQDVVTLLE 368
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 301 SdyQDIGKNVQFHA-RNARLPIVT--RPQaLRRVMTNLLDNALKF---GDSAVIEIDEDERQVAIRIMDNGPGIPEAELE 374
Cdd:COG5805 369 T--EAILHNIQIRLeLLDEDPFIYcdENQ-IKQVFINLIKNAIEAmpnGGTITIHTEEEDNSVIIRVIDEGIGIPEERLK 445
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 838655919 375 AVLQPFYRVETSrnretgGTGLGLAIAAQLTAQLDGKLHIANRAEGGLAVSVTLP 429
Cdd:COG5805 446 KLGEPFFTTKEK------GTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
227-429 |
2.54e-18 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 86.95 E-value: 2.54e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 227 QILASISHDLQTPITRMK-----LRI-EMADQPELRDKLLSDLDNMSRLVREGIAYARSSESLEETTlklELNAWVNSIA 300
Cdd:COG5809 272 ELAAGIAHEIRNPLTSLKgfiqlLKDtIDEEQKTYLDIMLSELDRIESIISEFLVLAKPQAIKYEPK---DLNTLIEEVI 348
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 301 S--DYQDIGKNVQFHAR-NARLP-IVTRPQALRRVMTNLLDNALKF---GDSAVIEI-DEDERQVAIRIMDNGPGIPEAE 372
Cdd:COG5809 349 PllQPQALLKNVQIELElEDDIPdILGDENQLKQVFINLLKNAIEAmpeGGNITIETkAEDDDKVVISVTDEGCGIPEER 428
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 838655919 373 LEAVLQPFYrvetsrNRETGGTGLGLAIAAQLTAQLDGKLHIANRAEGGLAVSVTLP 429
Cdd:COG5809 429 LKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLP 479
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
213-429 |
5.01e-18 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 86.63 E-value: 5.01e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 213 EMQSRIQTylrERAQI----LASISHDLQTPITRMKLRIEM------------ADQP-ELRDKLLS------DLDNMSRL 269
Cdd:PRK10490 651 EEQARLAS---EREQLrnalLAALSHDLRTPLTVLFGQAEIltldlasegsphARQAsEIRQQVLNttrlvnNLLDMARI 727
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 270 VREGIAYARSSESLEETtlklelnawvnsIASDYQDIGKNVQFHARNARLP-----IVTRPQALRRVMTNLLDNALKF-G 343
Cdd:PRK10490 728 QSGGFNLRKEWLTLEEV------------VGSALQMLEPGLSGHPINLSLPepltlIHVDGPLFERVLINLLENAVKYaG 795
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 344 DSAVIEID--EDERQVAIRIMDNGPGIPEAELEAVLQPFYRVetsrNRETG--GTGLGLAIAAQLTAQLDGKLHIANRAE 419
Cdd:PRK10490 796 AQAEIGIDahVEGERLQLDVWDNGPGIPPGQEQLIFDKFARG----NKESAipGVGLGLAICRAIVEVHGGTIWAENRPE 871
|
250
....*....|
gi 838655919 420 GGLAVSVTLP 429
Cdd:PRK10490 872 GGACFRVTLP 881
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
216-430 |
8.56e-18 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 85.19 E-value: 8.56e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 216 SRIQT-YLRERAQILASISHDLQTPITRMK-----LRIEMADQPE--LRDKLLSDLDNMSRLVregiayarsSESL---E 284
Cdd:COG5808 231 QEINTqKLELIGTFAASTAHEIRNPLTSIKgfiqlLQEKYPELEDqkYFDIIQEEIQRINQIV---------SEFLvlgK 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 285 ETTLKLE---LNAWVNSIAS--DYQDIGKNVQFHARNARLPIVTR--PQALRRVMTNLLDNALKF---GDSAVIEIDEDE 354
Cdd:COG5808 302 PTAKKLElddLNELIEEILSiiDSEANLKNIRVEKQSLDEPLHIKcdKDRIKQVLLNLIKNAIEAmkeGGKLTISIENDD 381
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 838655919 355 RQVAIRIMDNGPGIPEAELEAVLQPFYrveTSRNretGGTGLGLAIAAQLTAQLDGKLHIANRAEGGLAVSVTLPR 430
Cdd:COG5808 382 EKAVIEVIDNGEGIPEDIIDEIFEPFV---TTKE---GGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTFTIRLPL 451
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-428 |
1.47e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 78.22 E-value: 1.47e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 328 LRRVMTNLLDNALKF-GDSAVIEIDEDERQVA-IRIMDNGPGIPEAELEAVLQPFYRvetSRNRETGGTGLGLAIAAQLT 405
Cdd:cd16940 14 LFLLLRNLVDNAVRYsPQGSRVEIKLSADDGAvIRVEDNGPGIDEEELEALFERFYR---SDGQNYGGSGLGLSIVKRIV 90
|
90 100
....*....|....*....|...
gi 838655919 406 AQLDGKLHIANRAEGGLAVSVTL 428
Cdd:cd16940 91 ELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-430 |
2.84e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 77.09 E-value: 2.84e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 328 LRRVMTNLLDNALKFGDSAV-IEIDEDERQVAIRIMDNGPGIPEAELEAVLQPFYRVETSRNRETGGTGLGLAIAAQLTA 406
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVrIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVAL 80
|
90 100
....*....|....*....|....
gi 838655919 407 QLDGKLHIANRAEGGLAVSVTLPR 430
Cdd:cd16939 81 WHGGHVECDDSELGGACFRLTWPR 104
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
225-429 |
4.32e-16 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 79.67 E-value: 4.32e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 225 RAQILASISHDLQTPITRMKLRIEMADQPEL----RDKLLS----DLDNMSRLVREGIAYARSsesleETTLKLELNAWV 296
Cdd:PRK11006 204 RRNFFANVSHELRTPLTVLQGYLEMMQDQPLegalREKALHtmreQTQRMEGLVKQLLTLSKI-----EAAPTIDLNEKV 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 297 N-------------SIASDYQDIGKNVqfharNARLPIVTRPQALRRVMTNLLDNALKFgDSAVIEIDEDERQVA----I 359
Cdd:PRK11006 279 DvpmmlrvlereaqTLSQGKHTITFEV-----DNSLKVFGNEDQLRSAISNLVYNAVNH-TPEGTHITVRWQRVPqgaeF 352
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 360 RIMDNGPGIPEAELEAVLQPFYRVETSRNRETGGTGLGLAIAAQLTAQLDGKLHIANRAEGGLAVSVTLP 429
Cdd:PRK11006 353 SVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
325-423 |
5.34e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 73.26 E-value: 5.34e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 325 PQALRRVMTNLLDNALKF---GDSAVIEIDEDERQVAIRIMDNGPGIPEAELEAVLQPFYRVETSRNRETGgTGLGLAIA 401
Cdd:cd16945 2 PFLLRQAINNLLDNAIDFspeGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKS-TGLGLAFV 80
|
90 100
....*....|....*....|..
gi 838655919 402 AQLTAQLDGKLHIANRAEGGLA 423
Cdd:cd16945 81 QEVAQLHGGRITLRNRPDGVLA 102
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-429 |
2.92e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 71.26 E-value: 2.92e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 328 LRRVMTNLLDNALKFG-DSAVIEID--EDERQVAIRIMDNGPGIPEAELEAVLQPFYRVETSRNreTGGTGLGLAIAAQL 404
Cdd:cd16923 1 LQRVFSNLLSNAIKYSpENTRIYITsfLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRN--TEGAGLGLSIAKAI 78
|
90 100
....*....|....*....|....*
gi 838655919 405 TAQLDGKLHIANRAEGGLaVSVTLP 429
Cdd:cd16923 79 IELHGGSASAEYDDNHDL-FKVRLP 102
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
215-430 |
3.41e-15 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 77.70 E-value: 3.41e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 215 QSRIQTYLR--ERAQIL----ASISHDLQTPITRMKLRIEM----ADQPELRDKL---LSDLDNMSRLVREGIAYARSSE 281
Cdd:PRK11360 374 RKRLQRRVArqERLAALgelvAGVAHEIRNPLTAIRGYVQIwrqqTSDPPSQEYLsvvLREVDRLNKVIDQLLEFSRPRE 453
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 282 SLEEttlKLELNAWVNSIASDYQDIGK--NVQFH-ARNARLP-IVTRPQALRRVMTNLLDNALK-FGDSAVIEID---ED 353
Cdd:PRK11360 454 SQWQ---PVSLNALVEEVLQLFQTAGVqaRVDFEtELDNELPpIWADPELLKQVLLNILINAVQaISARGKIRIRtwqYS 530
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 838655919 354 ERQVAIRIMDNGPGIPEAELEAVLQPFYrveTSRNRetgGTGLGLAIAAQLTAQLDGKLHIANRAEGGLAVSVTLPR 430
Cdd:PRK11360 531 DGQVAVSIEDNGCGIDPELLKKIFDPFF---TTKAK---GTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPI 601
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-431 |
8.09e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 70.31 E-value: 8.09e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 328 LRRVMTNLLDNALKF---GDSAVIEIDEDERQVAIRIMDNGPGIPEAELEAVLQPFYRVETSRNRETGGTGLGLAIAAql 404
Cdd:cd16952 1 LRSAFSNLVSNAVKYtppSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVK-- 78
|
90 100
....*....|....*....|....*..
gi 838655919 405 taqldgklHIANRAEGGLAVSVTLPRG 431
Cdd:cd16952 79 --------HVMSRHDARLLIASELGKG 97
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
229-410 |
8.93e-15 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 76.55 E-value: 8.93e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 229 LASISHDLQTP----ITRMKLrIEMADQPELRDKLLSDLDNMSRLVREGIAYARSSESLEETTLKLELNAW-----VNSI 299
Cdd:PRK10841 451 LATVSHELRTPlygiIGNLDL-LQTKELPKGVDRLVTAMNNSSSLLLKIISDILDFSKIESEQLKIEPREFsprevINHI 529
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 300 ASDYqdigknvqfharnarLPIVTR--------------------PQALRRVMTNLLDNALKFGDSA--VIEIDEDERQV 357
Cdd:PRK10841 530 TANY---------------LPLVVKkrlglycfiepdvpvalngdPMRLQQVISNLLSNAIKFTDTGciVLHVRVDGDYL 594
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 838655919 358 AIRIMDNGPGIPEAELEAVLQPFYRVETSRNRETGGTGLGLAIAAQLTAQLDG 410
Cdd:PRK10841 595 SFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDG 647
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
167-429 |
1.07e-14 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 76.22 E-value: 1.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 167 SWIAVRQVVRPFLQFtraVDSLDPAAHSPMTEKGPV----EVRQAAHAFNEMQSRIQTYLR-------ERAQILA----- 230
Cdd:PRK15347 314 FLLLRRYLAKPLWRF---VDIINKTGPAALEPRLPEnrldELGSIAKAYNQLLDTLNEQYDtlenkvaERTQALAeakqr 390
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 231 -------------SISHDLQTPITRMKLRIEM-------ADQPELRD-------KLLSDLDNM---SRlvregIAYARSS 280
Cdd:PRK15347 391 aeqankrksehltTISHEIRTPLNGVLGALELlqntpltAEQMDLADtarqctlSLLAIINNLldfSR-----IESGQMT 465
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 281 ESLEETTLKLELNAWVNSIASDYQDIGKNVQ-FHARNARLPIVTRPQALRRVMTNLLDNALKFGDSAVI--EIDEDERQV 357
Cdd:PRK15347 466 LSLEETALLPLLDQAMLTIQGPAQSKSLTLRtFVGAHVPLYLHLDSLRLRQILVNLLGNAVKFTETGGIrlRVKRHEQQL 545
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 838655919 358 AIRIMDNGPGIPEAELEAVLQPFYRVETSrnreTGGTGLGLAIAAQLTAQLDGKLHIANRAEGGLAVSVTLP 429
Cdd:PRK15347 546 CFTVEDTGCGIDIQQQQQIFTPFYQADTH----SQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLP 613
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
212-431 |
1.60e-14 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 74.88 E-value: 1.60e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 212 NEMQSRIQTY--LRERAQILASISHD----LQTpITRMklrIEMADQPELRDKLLSDLDNMSRLVRegiayaRSSESLEE 285
Cdd:COG3290 174 TELERLEEELegVKELAEALRAQRHDfrnhLHT-ISGL---LQLGEYDEALEYIDEISEELQELID------SLLSRIGN 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 286 TTLKLELNAWVNSIASdyqdigKNVQFH-ARNARLP-IVTRPQALRRVMTNLLDNALkfgDSAV----------IEIDED 353
Cdd:COG3290 244 PVLAALLLGKAARARE------RGIDLTiDIDSDLPdLPLSDTDLVTILGNLLDNAI---EAVEklpeeerrveLSIRDD 314
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 838655919 354 ERQVAIRIMDNGPGIPEAELEAVLQPFYrveTSRNREtgGTGLGLAIAAQLTAQLDGKLHIANRAEGGLAVSVTLPRG 431
Cdd:COG3290 315 GDELVIEVEDSGPGIPEELLEKIFERGF---STKLGE--GRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKE 387
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-429 |
2.00e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 68.89 E-value: 2.00e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 328 LRRVMTNLLDNALKF---GDSAVIEI----DEDERQVAIRimDNGPGIPEAELEAVLQPFYRVETsrNRETGGTGLGLAI 400
Cdd:cd16921 1 LGQVLTNLLGNAIKFrrpRRPPRIEVgaedVGEEWTFYVR--DNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAI 76
|
90 100
....*....|....*....|....*....
gi 838655919 401 AAQLTAQLDGKLHIANRAEGGLAVSVTLP 429
Cdd:cd16921 77 VRKIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
223-429 |
3.11e-14 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 74.94 E-value: 3.11e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 223 RERAQILASISHDLQTPITRMKLRIEM-ADQPEL---RDKL-------------LSDLDNMSRLVREGIAYARSSESLE- 284
Cdd:PRK11466 442 QAKSAFLAAMSHEIRTPLYGILGTAQLlADNPALnaqRDDLraitdsgeslltiLNDILDYSAIEAGGKNVSVSDEPFEp 521
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 285 ----ETTLKL---ELNAWVNSIASDYQDIgknvqfharnarLP--IVTRPQALRRVMTNLLDNALKFGDSAVIEIDE--D 353
Cdd:PRK11466 522 rpllESTLQLmsgRVKGRPIRLATDIADD------------LPtaLMGDPRRIRQVITNLLSNALRFTDEGSIVLRSrtD 589
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 838655919 354 ERQVAIRIMDNGPGIPEAELEAVLQPFYRVETSRnretGGTGLGLAIAAQLTAQLDGKLHIANRAEGGLAVSVTLP 429
Cdd:PRK11466 590 GEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLP 661
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
167-430 |
5.97e-14 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 73.13 E-value: 5.97e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 167 SWIAVRQVVRPFLQFTRAVDSLDPAAHSPMTEKGPVEVRQAAHAFNEMQSRIQTYLRERAQILASIS------------- 233
Cdd:COG2972 174 SYLLSRSITRPIKRLKKAMKKVEKGDLVRLEVSGNDEIGILARSFNEMVERIKELIEEVYELELEKKeaelkalqaqinp 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 234 HDLQTPITRMKLRIEMADQPELRDkLLSDLdnmSRLVREGIayarsSESLEETTLKLELNawvnsIASDYQDI-----GK 308
Cdd:COG2972 254 HFLFNTLNSIRWLAELEDPEEAEE-MLEAL---SKLLRYSL-----SKGDELVTLEEELE-----LIKSYLEIqklrfGD 319
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 309 NVQFH------ARNARLPivtrpqalRRVMTNLLDNALKFG-----DSAVIEID--EDERQVAIRIMDNGPGIPEAELEA 375
Cdd:COG2972 320 RLEVEieideeLLDLLIP--------KLILQPLVENAIEHGiepkeGGGTIRISirKEGDRLVITVEDNGVGMPEEKLEK 391
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 838655919 376 VLQPFyrvetsrNRETGGTGLGLAIAAQLTAQLDGK---LHIANRAEGGLAVSVTLPR 430
Cdd:COG2972 392 LLEEL-------SSKGEGRGIGLRNVRERLKLYYGEeygLEIESEPGEGTTVTIRIPL 442
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
203-429 |
7.50e-14 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 74.00 E-value: 7.50e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 203 EVRQAAHAFNEMQSRIQTYLRERAQILASISHDLQTPITRMKLRIEMADQpelrdkllSDLDNMSRLVREGIAYARSSES 282
Cdd:PRK09959 690 ETRDLIHALEVERNKAINATVAKSQFLATMSHEIRTPISSIMGFLELLSG--------SGLSKEQRVEAISLAYATGQSL 761
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 283 LEETTLKLElnawVNSIAS-DYQ------DIGKNVQ-----FHARNARLPIVTR--------------PQALRRVMTNLL 336
Cdd:PRK09959 762 LGLIGEILD----VDKIESgNYQlqpqwvDIPTLVQntchsFGAIAASKSIALScsstfpdhylvkidPQAFKQVLSNLL 837
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 337 DNALKFGD-------SAVIEIDEDERQVAIRIMDNGPGIPEAELEAVLQPFyrVETSRNRETGGTGLGLAIAAQLTAQLD 409
Cdd:PRK09959 838 SNALKFTTegavkitTSLGHIDDNHAVIKMTIMDSGSGLSQEEQQQLFKRY--SQTSAGRQQTGSGLGLMICKELIKNMQ 915
|
250 260
....*....|....*....|
gi 838655919 410 GKLHIANRAEGGLAVSVTLP 429
Cdd:PRK09959 916 GDLSLESHPGIGTTFTITIP 935
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
227-400 |
8.22e-14 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 72.29 E-value: 8.22e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 227 QILASISHDLQTPITRMKLRIE----------MADQPELRDKLL----SDLDNMSRLVREGIAYARSS-ESLEETTLKLE 291
Cdd:PRK09303 153 RVLAMLAHDLRTPLTAASLALEtlelgqidedTELKPALIEQLQdqarRQLEEIERLITDLLEVGRTRwEALRFNPQKLD 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 292 LNAWVNSIASDYQDI--GKNVQFHAR-NARLPIV-TRPQALRRVMTNLLDNALKF-GDSAVIEIDEDER---QVAIRIMD 363
Cdd:PRK09303 233 LGSLCQEVILELEKRwlAKSLEIQTDiPSDLPSVyADQERIRQVLLNLLDNAIKYtPEGGTITLSMLHRttqKVQVSICD 312
|
170 180 190
....*....|....*....|....*....|....*..
gi 838655919 364 NGPGIPEAELEAVLQPFYRVetSRNRETGGTGLGLAI 400
Cdd:PRK09303 313 TGPGIPEEEQERIFEDRVRL--PRDEGTEGYGIGLSV 347
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
227-429 |
8.47e-14 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 72.19 E-value: 8.47e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 227 QILASISHDLQTPIT-------RMKLRIEMADQPELRDKLLSDLDNMSRLVREGIAYARSSESLEETtlkLELNAWVNSI 299
Cdd:COG3852 137 ELAAGLAHEIRNPLTgirgaaqLLERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRPPEREP---VNLHEVLERV 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 300 ASDYQ-DIGKNVQFHAR-NARLPIVT-RPQALRRVMTNLLDNALK-FGDSAVIEI------------DEDERQVAIRIMD 363
Cdd:COG3852 214 LELLRaEAPKNIRIVRDyDPSLPEVLgDPDQLIQVLLNLVRNAAEaMPEGGTITIrtrverqvtlggLRPRLYVRIEVID 293
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 838655919 364 NGPGIPEAELEAVLQPFYrveTSRnreTGGTGLGLAIAAQLTAQLDGKLHIANRAEGGLAVSVTLP 429
Cdd:COG3852 294 NGPGIPEEILDRIFEPFF---TTK---EKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLP 353
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-428 |
1.30e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 66.71 E-value: 1.30e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 328 LRRVMTNLLDNAL----KFGDSAV-IEIDEDERQVAIRIMDNGPGIPEAELEAVLQPFYrvetsRNRETG-GTGLGLAIA 401
Cdd:cd16976 1 IQQVLMNLLQNALdamgKVENPRIrIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF-----TTKPVGkGTGLGLSIS 75
|
90 100
....*....|....*....|....*..
gi 838655919 402 AQLTAQLDGKLHIANRAEGGLAVSVTL 428
Cdd:cd16976 76 YGIVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
168-430 |
1.44e-12 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 69.28 E-value: 1.44e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 168 WIAVRQVVRPFLQFTRAVDSLDPAAHSPMTEKGPVEVRQAAHAFNEM-QSRIQTYLRERAQiLASISHDLQTPI-----T 241
Cdd:PRK10815 209 WLAAWWSLRPIEALAKQVRELEEGEREQLDPNPPRELTSLVRNLNRLlKNERERYTKYRTT-LTDLTHSLKTPLavlqsT 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 242 RMKLR------IEMAdQPELrdkllsdLDNMSRLVREgIAY--ARSSESLEETTLKLELN---AWVNSIASD----YQ-- 304
Cdd:PRK10815 288 LRSLRsgkqmsVEQA-EPIM-------LEQISRISQQ-IGYylHRASMRSEHNLLSRELHsvaPLLDNLTSAlnkvYQrk 358
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 305 ------DIGKNVQFharnarlpiVTRPQALRRVMTNLLDNALKFGDSAV-IEIDEDERQVAIRIMDNGPGIPEAELEAVL 377
Cdd:PRK10815 359 gvnitlDISPEITF---------VGEKNDFMEVMGNVLDNACKYCLEFVeISARQTDEHLHIVVEDDGPGIPESKRELIF 429
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 838655919 378 QPFYRVETSRNretgGTGLGLAIAAQLTAQLDGKLHIANRAEGGLAVSVTLPR 430
Cdd:PRK10815 430 DRGQRADTLRP----GQGLGLSVAREITEQYEGKISAGDSPLGGARMEVIFGR 478
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
325-430 |
2.17e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 63.21 E-value: 2.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 325 PQALRRVMTNLLDNALK----FGdSAVIEIDEDERQVAIRIMDNGPGIPEAELEAVLQPFYrveTSRNRETgGTGLGLAI 400
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQamegRG-RITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFF---TTKPVGE-GTGLGLSL 75
|
90 100 110
....*....|....*....|....*....|
gi 838655919 401 AAQLTAQLDGKLHIANRAEGGLAVSVTLPR 430
Cdd:cd16943 76 SYRIIQKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
325-429 |
3.53e-12 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 62.90 E-value: 3.53e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 325 PQALRRVMTNLLDNALKFGDSA-----VIEIDEDERqVAIRIMDNGPGIPEAELEAVLQPFYRVETSRNRETGGTGLGLA 399
Cdd:cd16925 2 AEKYERVVLNLLSNAFKFTPDGgrircILEKFRLNR-FLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 838655919 400 IAAQLTAQLDGKLHIANRAEGGLAVSVTLP 429
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
223-429 |
4.13e-12 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 68.04 E-value: 4.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 223 RERAQILASISHDLQTPI------TRMKLRIEMADQPELRDK-----------LLSDLDNMSRLVREgiayarsseslee 285
Cdd:PRK11091 281 RDKTTFISTISHELRTPLngivglSRILLDTELTAEQRKYLKtihvsaitlgnIFNDIIDMDKMERR------------- 347
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 286 ttlKLEL-NAWVN--SIASDYQDIG------KNVQFH-ARNARLP--IVTRPQALRRVMTNLLDNALKF---GDSAVIEI 350
Cdd:PRK11091 348 ---KLQLdNQPIDftDFLADLENLSglqaeqKGLRFDlEPLLPLPhkVITDGTRLRQILWNLISNAVKFtqqGGVTVRVR 424
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 351 DEDERQVAIRIMDNGPGIPEAELEAVLQPFYRVETSR-NRETGGTGLGLAIAAQLTAQLDGKLHIANRAEGGLAVSVTLP 429
Cdd:PRK11091 425 YEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHgGKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIH 504
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
326-426 |
1.95e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 60.55 E-value: 1.95e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 326 QALRRVMTNLLDNALKF---GDSAVIEIDEDERQVAIRIMDNGPGIPEAELEAVLQPFYRVETSRNREtGGTGLGLAIAA 402
Cdd:cd16975 3 LLLSRALINIISNACQYapeGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSG-GHYGMGLYIAK 81
|
90 100
....*....|....*....|....
gi 838655919 403 QLTAQLDGKLHIANRAEGGLAVSV 426
Cdd:cd16975 82 NLVEKHGGSLIIENSQKGGAEVTV 105
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
327-411 |
5.67e-11 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 64.49 E-value: 5.67e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 327 ALR--RVMTNLLDNALKFGDSAVIEIDEDER-----QVAIRIM--DNGPGIPEAELEAVLQPFYRVETSRNRETGGTGLG 397
Cdd:PRK11107 406 PLRlqQIITNLVGNAIKFTESGNIDILVELRalsntKVQLEVQirDTGIGISERQQSQLFQAFRQADASISRRHGGTGLG 485
|
90
....*....|....
gi 838655919 398 LAIAAQLTAQLDGK 411
Cdd:PRK11107 486 LVITQKLVNEMGGD 499
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
327-429 |
1.05e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 58.32 E-value: 1.05e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 327 ALRRVMTNLLDNA--------LKFGDSAV-IEIDEDERqVAIRIMDNGPGIPEAELEAVLQPFYrveTSRNRetgGTGLG 397
Cdd:cd16944 4 QISQVLTNILKNAaeaiegrpSDVGEVRIrVEADQDGR-IVLIVCDNGKGFPREMRHRATEPYV---TTRPK---GTGLG 76
|
90 100 110
....*....|....*....|....*....|..
gi 838655919 398 LAIAAQLTAQLDGKLHIANRAEGGLAVSVTLP 429
Cdd:cd16944 77 LAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
215-431 |
1.58e-10 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 61.17 E-value: 1.58e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 215 QSRIQTYLRERAQILASIsHD--LQTpITRMKLRIEMADQ--PELRDKLLSDLDNMSRLVREGIAYARS------SESLE 284
Cdd:COG4585 44 ARAEEAREEERRRIAREL-HDgvGQS-LSAIKLQLEAARRllDADPEAAREELEEIRELAREALAELRRlvrglrPPALD 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 285 ETTLKLELNAWVNSIASDYqdiGKNVQFHA--RNARLPIVTRpQALRRVMTNLLDNALKFGD--SAVIEIDEDERQVAIR 360
Cdd:COG4585 122 DLGLAAALEELAERLLRAA---GIRVELDVdgDPDRLPPEVE-LALYRIVQEALTNALKHAGatRVTVTLEVDDGELTLT 197
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 838655919 361 IMDNGPGIPEAEleavlqpfyrvetsrnreTGGTGLGLAIAAQLTAQLDGKLHIANRAEGGLAVSVTLPRG 431
Cdd:COG4585 198 VRDDGVGFDPEA------------------APGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLA 250
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-429 |
4.04e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 56.91 E-value: 4.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 328 LRRVMTNLLDNALKF---GDSAVIEIDEDERQVAIRIMDNGPGIPEAELEAVLQPFYRVETSRNrETGGTGLGLAIAAQL 404
Cdd:cd16948 6 LSFIIGQIVSNALKYskqGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRN-FQESTGMGLYLVKKL 84
|
90 100
....*....|....*....|....*
gi 838655919 405 TAQLDGKLHIANRAEGGLAVSVTLP 429
Cdd:cd16948 85 CDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-429 |
4.61e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 56.64 E-value: 4.61e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 328 LRRVMTNLLDNALKFGDSAVIEIDE--------DERQVAIRIMDNGPGIPEAELEAVLQPFYRVETSrnretgGTGLGLA 399
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEGGCERREltirtspaDDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLS 74
|
90 100 110
....*....|....*....|....*....|
gi 838655919 400 IAAQLTAQLDGKLHIANRAEGGLAVSVTLP 429
Cdd:cd16920 75 ICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-424 |
1.81e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 54.89 E-value: 1.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 328 LRRVMTNLLDNALKFGDSAVIEID----EDERQVAIRIMDNGPGIPEAELEAVLQPFYrVETSRNRETG-GTGLGLAIAA 402
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDTGRITvsamPTGKMVTISVEDEGPGIPQEKLESIFDRFY-TERPANEAFGqHSGLGLSISR 79
|
90 100
....*....|....*....|..
gi 838655919 403 QLTAQLDGKLHIANRAEGGLAV 424
Cdd:cd16953 80 QIIEAHGGISVAENHNQPGQVI 101
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
254-429 |
5.15e-09 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 57.87 E-value: 5.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 254 ELRDKLLSDLDNMSRLVREGIAYARSSE-SLEETTLKLELNAWVNSIASDYQDIGKNVQFHARNARLPIVTRPQALRRVM 332
Cdd:PRK10364 274 QLAQVMAKEADRLNRVVSELLELVKPTHlALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVL 353
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 333 TNLLDNALK-FGDSAVI--EIDEDERQVAIRIMDNGPGIPEAELEAVLQPFYrveTSRNRetgGTGLGLAIAAQLTAQLD 409
Cdd:PRK10364 354 LNLYLNAIQaIGQHGVIsvTASESGAGVKISVTDSGKGIAADQLEAIFTPYF---TTKAE---GTGLGLAVVHNIVEQHG 427
|
170 180
....*....|....*....|
gi 838655919 410 GKLHIANRAEGGLAVSVTLP 429
Cdd:PRK10364 428 GTIQVASQEGKGATFTLWLP 447
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
334-429 |
6.96e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 53.06 E-value: 6.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 334 NLLDNALK-FGDSAV------IEIDEDERQVAIRIMDNGPGIPEAELEAVlqpFYRVETSrnRETGGTGLGLAIAAQLTA 406
Cdd:cd16915 7 NLIDNALDaLAATGApnkqveVFLRDEGDDLVIEVRDTGPGIAPELRDKV---FERGVST--KGQGERGIGLALVRQSVE 81
|
90 100
....*....|....*....|...
gi 838655919 407 QLDGKLHIANRAEGGLAVSVTLP 429
Cdd:cd16915 82 RLGGSITVESEPGGGTTFSIRIP 104
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-429 |
1.55e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 52.40 E-value: 1.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 328 LRRVMTNLLDNA---LKFGDSAVIEIDEDERQVAIR-----------IMDNGPGIPeAELEAVLqpFYRVETSRnreTGG 393
Cdd:cd16918 1 LIQVFLNLVRNAaqaLAGSGGEIILRTRTQRQVTLGhprhrlalrvsVIDNGPGIP-PDLQDTI--FYPMVSGR---ENG 74
|
90 100 110
....*....|....*....|....*....|....*.
gi 838655919 394 TGLGLAIAAQLTAQLDGKLHIANRAeGGLAVSVTLP 429
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQP-GHTVFSVSLP 109
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-429 |
8.86e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 49.47 E-value: 8.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 328 LRRVMTNLLDNALKF--GDSAVIEIDEDERQVAIRIMDNGPGIPEAeleavlqpfyrvetsrnRETGGTGLGLAIAAQLT 405
Cdd:cd16917 1 LYRIVQEALTNALKHagASRVRVTLSYTADELTLTVVDDGVGFDGP-----------------APPGGGGFGLLGMRERA 63
|
90 100
....*....|....*....|....
gi 838655919 406 AQLDGKLHIANRAEGGLAVSVTLP 429
Cdd:cd16917 64 ELLGGTLTIGSRPGGGTRVTARLP 87
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
225-429 |
2.08e-07 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 53.40 E-value: 2.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 225 RAQILASISHDLQTPITRM--------KLRIEMADQPELrDKLLSDLDNMSRLVregiayarsseslEETTL--KLELNA 294
Cdd:PRK10618 450 RKAFLQNIGDELKQPLQSLaqlaaqlrQTSDEEQQQPEL-DQLAEQSDVLVRLV-------------DNIQLlnMLETQD 515
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 295 W-----VNSIASDYQDIGKNV-------------QFHARNARLPIVTRPqALRRVMTNLLDNAL---KFGD-SAVIEIDE 352
Cdd:PRK10618 516 WkpeqeLFSLQDLIDEVLPEVlpaikrkglqlliHNHLKAEQLRIGDRD-ALRKILLLLLNYAItttAYGKiTLEVDQDE 594
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 838655919 353 DER-QVAIRIMDNGPGIPEAELEAVLQPFYRvETSRNRETGGTGLGLAIAAQLTAQLDGKLHIANRAEGGLAVSVTLP 429
Cdd:PRK10618 595 SSPdRLTIRILDTGAGVSIKELDNLHFPFLN-QTQGDRYGKASGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHLK 671
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
309-431 |
2.34e-07 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 53.14 E-value: 2.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 309 NVQFHARNARlpIVTRPQALRRVMTNLLDNALK-FGDSAVIEIDEDE-----------------RQVAIRIMDNGPGIPE 370
Cdd:PRK13837 544 DFDQDQEPAV--VEGNPAELQQVLMNLCSNAAQaMDGAGRVDISLSRaklrapkvlshgvlppgRYVLLRVSDTGAGIDE 621
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 838655919 371 AELEAVLQPFYrveTSRNretGGTGLGLAIAAQLTAQLDGKLHIANRAEGGLAVSVTLPRG 431
Cdd:PRK13837 622 AVLPHIFEPFF---TTRA---GGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPPS 676
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
359-412 |
1.20e-06 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 50.08 E-value: 1.20e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 838655919 359 IRIMDNGPGIPeAELEAVLqpFYRVETSRNretGGTGLGLAIAAQLTAQLDGKL 412
Cdd:PRK11073 283 IDIEDNGPGIP-PHLQDTL--FYPMVSGRE---GGTGLGLSIARNLIDQHSGKI 330
|
|
| nifL_nitrog |
TIGR02938 |
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ... |
317-429 |
1.90e-06 |
|
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]
Pssm-ID: 131984 [Multi-domain] Cd Length: 494 Bit Score: 49.90 E-value: 1.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 317 ARLP-IVTRPQALRRVMTNLLDNALKFGDSAVIEIDE-------DERQVAIRIMDNGPGIPEAELEAVLQPFYrveTSRN 388
Cdd:TIGR02938 376 ATLPaILGRELQLRSLFKALVDNAIEAMNIKGWKRRElsittalNGDLIVVSILDSGPGIPQDLRYKVFEPFF---TTKG 452
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 838655919 389 RETGGTGLGLAIAAQLTAQLDGKLHIANRAEGGLAVSVTLP 429
Cdd:TIGR02938 453 GSRKHIGMGLSVAQEIVADHGGIIDLDDDYSEGCRIIVEFR 493
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
355-429 |
2.86e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 45.83 E-value: 2.86e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 838655919 355 RQVAIRIMDNGPGIPEAELEAVLQPFYRVetsrnRETG-GTGLGLAIAAQLTAQLDGKLHIANRAEGGLAVSVTLP 429
Cdd:cd16919 46 NYVCLEVSDTGSGMPAEVLRRAFEPFFTT-----KEVGkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
331-429 |
1.16e-05 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 47.60 E-value: 1.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 331 VMTNLLDNALKfgdsAVIEIDEDERQVA---------IRIMDNGPGIPEAELEAVLQPFYRVETSrNRetggtGLGLAIA 401
Cdd:PRK11086 437 ILGNLIENALE----AVGGEEGGEISVSlhyrngwlhCEVSDDGPGIAPDEIDAIFDKGYSTKGS-NR-----GVGLYLV 506
|
90 100
....*....|....*....|....*...
gi 838655919 402 AQLTAQLDGKLHIANRAEGGLAVSVTLP 429
Cdd:PRK11086 507 KQSVENLGGSIAVESEPGVGTQFFVQIP 534
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
224-278 |
2.40e-05 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 41.81 E-value: 2.40e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 838655919 224 ERAQILASISHDLQTPITRMKLRIEM-------ADQPELRDKLLSDLDNMSRLVREGIAYAR 278
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELlrdekldEEQREYLETILRSAERLLRLINDLLDLSR 62
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
355-429 |
3.50e-05 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 45.82 E-value: 3.50e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 838655919 355 RQVAIRIMDNGPGIPEAELEAVLQPFYrveTSRNrETGGTGLGLAIAAQLTAQLDGKLHIANRAEGGLAVSVTLP 429
Cdd:PRK13557 323 RYVSIAVTDTGSGMPPEILARVMDPFF---TTKE-EGKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFP 393
|
|
| PRK10935 |
PRK10935 |
nitrate/nitrite two-component system sensor histidine kinase NarQ; |
338-429 |
3.64e-05 |
|
nitrate/nitrite two-component system sensor histidine kinase NarQ;
Pssm-ID: 236800 [Multi-domain] Cd Length: 565 Bit Score: 46.00 E-value: 3.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 338 NALKFGDSAVIEI---DEDERQVAIRIMDNGPGIPEAElEAvLQPFyrvetsrnretggtglGLAIAAQLTAQLDGKLHI 414
Cdd:PRK10935 482 NAIKHANASEIAVscvTNPDGEHTVSIRDDGIGIGELK-EP-EGHY----------------GLNIMQERAERLGGTLTI 543
|
90
....*....|....*
gi 838655919 415 ANRAEGGLAVSVTLP 429
Cdd:PRK10935 544 SQPPGGGTTVSLTFP 558
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
224-281 |
7.28e-05 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 40.63 E-value: 7.28e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 838655919 224 ERAQILASISHDLQTPITRMKLRIEM-------ADQPELRDKLLSDLDNMSRLVREGIAYARSSE 281
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELlldtelsEEQREYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_TopVIB-like |
cd16933 |
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family ... |
311-406 |
8.10e-05 |
|
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family includes the histidine kinase-like ATPase (HATPase) domain of the B subunit of topoisomerase VI (Topo VIB). Topo VI is a heterotetrameric complex composed of two TopVIA and two TopVIB subunits and is categorized as a type II B DNA topoisomerase. It is found in archaea and also in plants. Type II enzymes cleave both strands of a DNA duplex and pass a second duplex through the resulting break in an ATP-dependent mechanism. DNA cleavage by Topo VI generates two-nucleotide 5'-protruding ends.
Pssm-ID: 340410 [Multi-domain] Cd Length: 203 Bit Score: 43.49 E-value: 8.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 311 QFHARNARLPIVTRP-QALRRVMTNLLDNALKFGDSAVI------EIDEDERQ-VAIRIMDNGPGIPEAELEAVlqpFYR 382
Cdd:cd16933 2 EFFRKNKEMLGFDNPiRSLYTTVRELVENSLDATEEAGIlpdikvEIEEIGKDhYKVIVEDNGPGIPEEQIPKV---FGK 78
|
90 100 110
....*....|....*....|....*....|.
gi 838655919 383 VETS---RNRETGGT-GLGLAIA---AQLTA 406
Cdd:cd16933 79 VLYGskyHNKQSRGQqGLGISAAvlySQMTT 109
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
222-278 |
1.04e-04 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 40.27 E-value: 1.04e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 838655919 222 LRERAQILASISHDLQTPITRMKLRIEM--------ADQPELRDKLLSDLDNMSRLVREGIAYAR 278
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELleeellddEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
335-429 |
3.00e-04 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 42.97 E-value: 3.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 335 LLDNALKFG----DSAVIEID--EDERQVAIRIMDNGPGIPEaeleavlqpfyrvetsRNRETGGTGLGLAIAAQLTAQL 408
Cdd:COG3920 407 LVTNALKHAflsgEGGRIRVSwrREDGRLRLTVSDNGVGLPE----------------DVDPPARKGLGLRLIRALVRQL 470
|
90 100
....*....|....*....|.
gi 838655919 409 DGKLHIanRAEGGLAVSVTLP 429
Cdd:COG3920 471 GGTLEL--DRPEGTRVRITFP 489
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
331-430 |
9.52e-04 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 41.36 E-value: 9.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 331 VMTNLLDNALKF------GDSAV-IEIDEDERQVAIRIMDNGPGIPEAELEAVlqpFYRVETSRNRETGGTGLGLAIAAQ 403
Cdd:PRK15053 436 IVGNLLDNAFEAslrsdeGNKIVeLFLSDEGDDVVIEVADQGCGVPESLRDKI---FEQGVSTRADEPGEHGIGLYLIAS 512
|
90 100
....*....|....*....|....*..
gi 838655919 404 LTAQLDGKLHIANRAEGGLAVSVTLPR 430
Cdd:PRK15053 513 YVTRCGGVITLEDNDPCGTLFSIFIPK 539
|
|
| top6b |
TIGR01052 |
DNA topoisomerase VI, B subunit; This model describes DNA topoisomerase VI, an archaeal type ... |
311-406 |
1.20e-03 |
|
DNA topoisomerase VI, B subunit; This model describes DNA topoisomerase VI, an archaeal type II DNA topoisomerase (DNA gyrase). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273417 [Multi-domain] Cd Length: 488 Bit Score: 40.96 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 311 QFHARNARLPIVTRP-QALRRVMTNLLDNALKFGDSAVI--EIDEDERQVA-----IRIMDNGPGIPEAELEAVL-QPFY 381
Cdd:TIGR01052 11 EFFRKNKHMLGYSGKiRSLTTVIHELVTNSLDACEEAGIlpDIKVEIEKIGkdhykVTVEDNGPGIPEEYIPKVFgKMLA 90
|
90 100
....*....|....*....|....*....
gi 838655919 382 RVETSRNRET-GGTGLGLAIA---AQLTA 406
Cdd:TIGR01052 91 GSKFHRIIQSrGQQGIGISGAvlySQMTT 119
|
|
| PRK04184 |
PRK04184 |
DNA topoisomerase VI subunit B; Validated |
335-408 |
3.51e-03 |
|
DNA topoisomerase VI subunit B; Validated
Pssm-ID: 235246 [Multi-domain] Cd Length: 535 Bit Score: 39.49 E-value: 3.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 335 LLDNALKFGDSAVI---------EIDEDERQVAIRIMDNGPGIPEAELEAVlqpFYRVETS----RNRETGGT-GLGLAi 400
Cdd:PRK04184 44 LVDNSLDACEEAGIlpdikieikRVDEGKDHYRVTVEDNGPGIPPEEIPKV---FGKLLYGskfhNLRQSRGQqGIGIS- 119
|
....*...
gi 838655919 401 AAQLTAQL 408
Cdd:PRK04184 120 AAVLYAQM 127
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
335-430 |
3.92e-03 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 37.20 E-value: 3.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 335 LLDNALKFGDSA------VIEIDEDERQVAIRIMDNGPGIPeaeLEAVLQPFyrvetsrnRETGGTGLGLAIAAQLTAQL 408
Cdd:COG2172 42 AVTNAVRHAYGGdpdgpvEVELELDPDGLEIEVRDEGPGFD---PEDLPDPY--------STLAEGGRGLFLIRRLMDEV 110
|
90 100
....*....|....*....|..
gi 838655919 409 DgklhiANRAEGGLAVSVTLPR 430
Cdd:COG2172 111 E-----YESDPGGTTVRLVKRL 127
|
|
| HATPase_AgrC-ComD-like |
cd16935 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
296-364 |
5.32e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.
Pssm-ID: 340412 [Multi-domain] Cd Length: 134 Bit Score: 37.17 E-value: 5.32e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 838655919 296 VNSIASDYQDIG--KNVQFHArNARLPIVT--RPQALRRVMTNLLDNALKfgdsAVIEIDEDERQ--VAIRIMDN 364
Cdd:cd16935 2 LDSLLSEKLELAreKGIEFTI-EIDIPILLpiSPLDLCIIFGNLLDNAIE----ACAKIDKENRFihLKIRQKKG 71
|
|
| COG1389 |
COG1389 |
DNA topoisomerase VI, subunit B [Replication, recombination and repair]; |
335-405 |
7.08e-03 |
|
DNA topoisomerase VI, subunit B [Replication, recombination and repair];
Pssm-ID: 440999 [Multi-domain] Cd Length: 530 Bit Score: 38.66 E-value: 7.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 838655919 335 LLDNALKFGDSA------VIEIDEDERQ--VAIRIMDNGPGIPEAELEAVL-QPFYRVETSRNRETGGT-GLGLAIA--- 401
Cdd:COG1389 43 AVDNSLDACEEAgilpdiKVSIERVDGKdiYRVTVEDNGPGIPPEQIPKVFgKLLYGSKFHVLRQSRGQqGIGISAAvly 122
|
....
gi 838655919 402 AQLT 405
Cdd:COG1389 123 AQMT 126
|
|
| HAMP |
pfam00672 |
HAMP domain; |
169-220 |
7.14e-03 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 34.52 E-value: 7.14e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 838655919 169 IAVRQVVRPFLQFTRAVDSLDPAA-HSPMTEKGPVEVRQAAHAFNEMQSRIQT 220
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDlDVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| |
