|
Name |
Accession |
Description |
Interval |
E-value |
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
22-268 |
8.89e-56 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 186.02 E-value: 8.89e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 22 NTTALTA-YNPYDHDGAVAVPNVTAATFGFRRAEDGEHSFgcayaieevlaRLDPDGtrhmkDIYARLTCPAVRACEASM 100
Cdd:COG0626 4 ATRAVHAgRDPDPQTGAVSPPIYLTSTFVFPSAEALAARF-----------AGEEGG-----YIYSRYGNPTRRALEEAL 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 101 KALEpGADWAFVFPSGMGAITALVQVCCHHsidGspvrDVVIHSSPLYGGTHALLHTFIQRWGFTHVEVNFRDPKELRDA 180
Cdd:COG0626 68 AALE-GGEAALAFASGMAAISAVLLALLKA---G----DHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAA 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 181 LEsygDRVGLVFCETPANPTLDMVDIRMVREIMDEvfdgrRRPPLGVDNTFM-GIFQHTLLMGADVAVYSATKFLSGHSD 259
Cdd:COG0626 140 IR---PNTKLVFLETPSNPTLEVVDIAAIAAIAHA-----AGALLVVDNTFAtPLLQRPLELGADIVVHSATKYLGGHSD 211
|
....*....
gi 818897694 260 LIAGFLVGK 268
Cdd:COG0626 212 VLGGAVVGR 220
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
36-268 |
1.17e-49 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 169.30 E-value: 1.17e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 36 GAVAVPNVTAATFGFRRAEDGEHSFGcayaieevlarldpdgTRHMKDIYARLTCPAVRACEASMKALEpGADWAFVFPS 115
Cdd:cd00614 1 GAVAPPIYQTSTFVFPSPAEAADLFA----------------LREGGYIYSRIGNPTVDALEKKLAALE-GGEAALAFSS 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 116 GMGAITALVqvcchHSIDGSPvrDVVIHSSPLYGGTHALLHTFIQRWGfthVEVNFRDPKELRDALESYGDRVGLVFCET 195
Cdd:cd00614 64 GMAAISTVL-----LALLKAG--DHVVASDDLYGGTYRLFERLLPKLG---IEVTFVDPDDPEALEAAIKPETKLVYVES 133
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 818897694 196 PANPTLDMVDIRMVREIMDEVfdGrrrPPLGVDNTFM-GIFQHTLLMGADVAVYSATKFLSGHSDLIAGFLVGK 268
Cdd:cd00614 134 PTNPTLKVVDIEAIAELAHEH--G---ALLVVDNTFAtPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGS 202
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
29-280 |
3.57e-45 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 159.07 E-value: 3.57e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 29 YNPYDHDGAVAVPNVTAATFGFRRAEDGEHSFgcayaiEEVLARLDPDGTRHMKDIYARLTCPAVRACEASMKALEpGAD 108
Cdd:PRK07049 27 YDPELSEGAVKPPVFLTSTFVFRSAEDGRDFF------DYVSGRKEPPAGEGAGLVYSRFNHPNSEIVEDRLAVYE-GAE 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 109 WAFVFPSGMGAITALVQvcchhsidgSPVR--DVVIHSSPLYGGTHALLHTFIQRWGFThvEVNFRD---PKELRDALE- 182
Cdd:PRK07049 100 SAALFSSGMSAIATTLL---------AFVRpgDVILHSQPLYGGTETLLAKTFRNFGVG--AVGFADglsEAAIGAAAEa 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 183 --SYGdRVGLVFCETPANPTLDMVDIRMVREIMDEVFDGR-RRPPLGVDNTFMG-IFQHTLLMGADVAVYSATKFLSGHS 258
Cdd:PRK07049 169 aaAKG-RVSLILIETPANPTNSLVDVAAVRRVADAIEARQgHRPIIACDNTLLGpVFQKPLEHGADLSVYSLTKYVGGHS 247
|
250 260
....*....|....*....|..
gi 818897694 259 DLIAGFLVGKTGIMTVVKPFTG 280
Cdd:PRK07049 248 DLVAGAVLGRKALIRQVRALRS 269
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
36-269 |
2.95e-41 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 147.38 E-value: 2.95e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 36 GAVAVPNVTAATFGFRRAedGEHSfgcAYaieevlarldpdgtrhmkdIYARLTCPAVRACEASMKALEpGADWAFVFPS 115
Cdd:pfam01053 16 GAVSVPIYLTSTYVFDFA--GEEG---GY-------------------DYSRSGNPTRDVLEERIAALE-GGAAALAFSS 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 116 GMGAITALVQVCCHHSidgspvrDVVIHSSPLYGGTHALLHTFIQRWGFTHVEVNFRDPKELRDALesyGDRVGLVFCET 195
Cdd:pfam01053 71 GMAAITAAILALLKAG-------DHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAI---KPNTKAVYLET 140
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 818897694 196 PANPTLDMVDIRMVREIMDEVfdgrrRPPLGVDNTFM-GIFQHTLLMGADVAVYSATKFLSGHSDLIAGFLVGKT 269
Cdd:pfam01053 141 PTNPLLKVVDIEAIAKLAKKH-----GILVVVDNTFAsPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNG 210
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
11-276 |
2.46e-37 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 137.63 E-value: 2.46e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 11 MSMSGGQAQVNNTTALTAYNPYDHDGAVAVPNVTAATFGFRRAEDGEHSFGcayaieevlarldpdGTRHmKDIYARLTC 90
Cdd:PRK07503 1 MRDSHNNTGFSTRAIHHGYDPLDHGGALVPPVYLTATFAFPTAEYGAECFA---------------GEEE-GHFYSRISN 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 91 PAVRACEASMKALEpGADWAFVFPSGMGAITALVQVCCHHSidgspvrDVVIHSSPLYGGTHALLHTFIQRWGFTHVEVN 170
Cdd:PRK07503 65 PTLALLEQRMASLE-GGEAAVALASGMGAITATLWTLLRPG-------DEVIVDQTLYGCTFAFLHHGLGEFGVTVRHVD 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 171 FRDPKELRDALesyGDRVGLVFCETPANPTLDMVDIRMVREIMDEvfdgrRRPPLGVDNTFMG-IFQHTLLMGADVAVYS 249
Cdd:PRK07503 137 LTDPAALKAAI---SDKTRMVYFETPANPNMRLVDIAAVAEIAHG-----AGAKVVVDNTYCTpYLQRPLELGADLVVHS 208
|
250 260
....*....|....*....|....*..
gi 818897694 250 ATKFLSGHSDLIAGFLVGKTGIMTVVK 276
Cdd:PRK07503 209 ATKYLGGHGDITAGLVVGGKALADRIR 235
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
36-278 |
3.83e-36 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 134.57 E-value: 3.83e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 36 GAVAVPNVTAATFGFRRAEDGehsfGCAYAIEEvlarldpDGTrhmkdIYARLTCPAVRACEASMKALEpGADWAFVFPS 115
Cdd:PRK06234 25 GSLATPIYQTSTFIFDSAEQG----GRRFAGEE-------SGY-----IYSRLGNPTSTEVENKLALLE-GGEAAVVAAS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 116 GMGAITALVQVCCHHSidgspvrDVVIHSSPLYGGTHALLHTFIQRWGfthVEVNFRDPKELRDALESYGDRVGLVFCET 195
Cdd:PRK06234 88 GMGAISSSLWSALKAG-------DHVVASDTLYGCTFALLNHGLTRYG---VEVTFVDTSNLEEVRNALKANTKVVYLET 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 196 PANPTLDMVDIRMVREIMDEVFDGRRrppLGVDNTFMGIF-QHTLLMGADVAVYSATKFLSGHSDLIAGFLVGKTGIMTV 274
Cdd:PRK06234 158 PANPTLKVTDIKAISNIAHENNKECL---VFVDNTFCTPYiQRPLQLGADVVVHSATKYLNGHGDVIAGFVVGKEEFINQ 234
|
....
gi 818897694 275 VKPF 278
Cdd:PRK06234 235 VKLF 238
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
27-281 |
3.94e-33 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 126.11 E-value: 3.94e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 27 TAYNPYDHDGAVAVPNVTAATFGFRRAEDGEHSFgcayAIEEvlarldpDGTrhmkdIYARLTCPAVRACEASMKALEpG 106
Cdd:PRK06767 13 HGYTSEEHKGSLTPPLFQTSTFTFETAQQGEASF----AGVD-------PSY-----IYSRLGNPTVKLFEERMAVLE-G 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 107 ADWAFVFPSGMGAITALVQVCchhsidgSPVRDVVIHSSPLYGGTHALLHTFIQRWGFTHvevNFRDPKELRDALESYGD 186
Cdd:PRK06767 76 GEEALAFGSGMAAISATLIGF-------LKAGDHIICSNGLYGCTYGFLEVLEEKFMITH---SFCDMETEADIENKIRP 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 187 RVGLVFCETPANPTLDMVDIRMVREIMDevfdgRRRPPLGVDNTFMGIF-QHTLLMGADVAVYSATKFLSGHSDLIAGFL 265
Cdd:PRK06767 146 NTKLIFVETPINPTMKLIDLKQVIRVAK-----RNGLLVIVDNTFCSPYlQRPLELGCDAVVHSATKYIGGHGDVVAGVT 220
|
250
....*....|....*..
gi 818897694 266 VGKTGIM-TVVKPFTGD 281
Cdd:PRK06767 221 ICKTRALaEKIRPMRKD 237
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
22-266 |
2.28e-30 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 118.59 E-value: 2.28e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 22 NTTALTA-YNPYDHDGAVAVPNVTAATFgfrrAEDGehsfgcayaieevlarldPDGTRHMKDiYARLTCPAVRACEASM 100
Cdd:PRK07811 14 ATRAIHAgYEPDPATGAVNPPIYASSTF----AQDG------------------VGGLRGGYE-YARTGNPTRTALEEQL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 101 KALEpGADWAFVFPSGMGAITALVQVCChhsidgSPVRDVVIhSSPLYGGTHALLHTFIQRWGFTHVEVNFRDPKELRDA 180
Cdd:PRK07811 71 AALE-GGAYGRAFSSGMAATDCLLRAVL------RPGDHIVI-PNDAYGGTFRLIDKVFTRWGVEYTPVDLSDLDAVRAA 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 181 LesyGDRVGLVFCETPANPTLDMVDIRMVREIMDEvfdgrRRPPLGVDNTFMG-IFQHTLLMGADVAVYSATKFLSGHSD 259
Cdd:PRK07811 143 I---TPRTKLIWVETPTNPLLSITDIAALAELAHD-----AGAKVVVDNTFASpYLQQPLALGADVVVHSTTKYIGGHSD 214
|
....*..
gi 818897694 260 LIAGFLV 266
Cdd:PRK07811 215 VVGGALV 221
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
27-294 |
2.84e-30 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 118.45 E-value: 2.84e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 27 TAYNPYDHDGAVAVPNVTAATFGFRRAEDGEHSFGcayaieevlarldpdGTRHmKDIYARLTCPAVRACEASMKALEpG 106
Cdd:TIGR01328 11 AGYPPKDQFGALTPPIYQTSTFVFDSCEQGGNRFA---------------GQES-GYIYSRLGNPTVSNLEGRIAFLE-G 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 107 ADWAFVFPSGMGAITALVqvcchhsIDGSPVRDVVIHSSPLYGGTHALLHTFIQRWGFTHVEVNFRDPKELRDALEsygD 186
Cdd:TIGR01328 74 TEAAVATSSGMGAIAATL-------LTILKAGDHLISDECLYGCTFALLEHALTKFGIQVDFINMAIPEEVKAHIK---D 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 187 RVGLVFCETPANPTLDMVDIRMVREIMDEvfdgrRRPPLGVDNTFMG-IFQHTLLMGADVAVYSATKFLSGHSDLIAGFL 265
Cdd:TIGR01328 144 NTKIVYFETPANPTMKLIDMERVCRDAHS-----QGVKVIVDNTFATpMLTNPVALGVDVVVHSATKYIGGHGDVVAGLI 218
|
250 260
....*....|....*....|....*....
gi 818897694 266 VGKTGIMTVVKPFTGDAVEASLMNAVPIW 294
Cdd:TIGR01328 219 CGKAELLQQIRMVGIKDMTGSVISPFDAW 247
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
23-266 |
1.08e-29 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 117.44 E-value: 1.08e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 23 TTALTA-YNPYDHDGAVAVPNVTAATFGFRRAEDGEHSFGcayaieevlarLDPDGtrhmkDIYARLTCPAVRACEASMK 101
Cdd:COG2873 10 TLALHAgQEPDPTTGARAVPIYQTTSYVFDDAEHAADLFA-----------LKEPG-----NIYTRIMNPTTDVLEKRIA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 102 ALEPGADwAFVFPSGMGAITALVQVCCHHsidGspvrDVVIHSSPLYGGTHALLHTFIQRWGfthVEVNF---RDPKELR 178
Cdd:COG2873 74 ALEGGVA-ALATASGQAAITLAILNLAEA---G----DHIVASSSLYGGTYNLFAHTLPRLG---IEVRFvdpDDPEAFE 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 179 DALesyGDRVGLVFCETPANPTLDMVDIRMVREIMDEvfdgrRRPPLGVDNTFMG-----IFQHtllmGADVAVYSATKF 253
Cdd:COG2873 143 AAI---DPNTKAIFGETIGNPALDVLDIEAIAEIAHE-----HGVPLIVDNTFATpylcrPIEH----GADIVVHSATKY 210
|
250
....*....|...
gi 818897694 254 LSGHSDLIAGFLV 266
Cdd:COG2873 211 IGGHGTSIGGVIV 223
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
85-269 |
1.62e-29 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 116.08 E-value: 1.62e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 85 YARLTCPAVRACEASMKALEpGADWAFVFPSGMGAITALVqvcchHSIDGSpvrDVVIHSSPLYGGTHALLHTFIQRWGF 164
Cdd:TIGR01329 41 YTRSGNPTRTALESLLAKLD-KADRAFAFSSGMAALDVIT-----RLLNNG---DEIIAGDDLYGGTDRLLTQVVPRSGV 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 165 THVEVNFRDPKELRDALesyGDRVGLVFCETPANPTLDMVDIRMVREIMDEVfdgrrRPPLGVDNTFM-GIFQHTLLMGA 243
Cdd:TIGR01329 112 VVVHVDTTDLDKVKAAL---GPKTKLVLLESPTNPLQKIVDIRKISEMAHAQ-----NALVVVDNTMMsPLLCNPLELGA 183
|
170 180
....*....|....*....|....*.
gi 818897694 244 DVAVYSATKFLSGHSDLIAGFLVGKT 269
Cdd:TIGR01329 184 DIVYHSATKFLAGHSDVMAGVLAVKG 209
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
84-275 |
1.59e-27 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 110.99 E-value: 1.59e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 84 IYARLTCPAVRACEASMKALEpGADWAFVFPSGMGAITALVqvcchHSIDGSPVRDVVIHSSplYGGTHALLHTFIQRWG 163
Cdd:PRK08249 57 IYSRNTNPTVQAFEEKVRILE-GAEAATAFSTGMAAISNTL-----YTFLKPGDRVVSIKDT--YGGTNKIFTEFLPRMG 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 164 FTHVEVNFRDPKELRDALESYGDrvgLVFCETPANPTLDMVDIRMVREIMDEVfdgrrrpplG----VDNTFMG-IFQHT 238
Cdd:PRK08249 129 VDVTLCETGDHEQIEAEIAKGCD---LLYLETPTNPTLKIVDIERLAAAAKKV---------GalvvVDNTFATpINQNP 196
|
170 180 190
....*....|....*....|....*....|....*..
gi 818897694 239 LLMGADVAVYSATKFLSGHSDLIAGFLVGKTGIMTVV 275
Cdd:PRK08249 197 LALGADLVIHSATKFLSGHADALGGVVCGSKELMEQV 233
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
49-278 |
1.76e-27 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 110.86 E-value: 1.76e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 49 GFRRAEDGEHS----------FGCAyaiEEVLARL--DPDGtrhmkDIYARLTCPAVRACEASMKALEpGADWAFVFPSG 116
Cdd:PRK08133 15 GQLRSPFGEHSealfltssfvFESA---AEAAARFagEEPG-----NIYSRFTNPTVTMFQERLAALE-GAEACVATASG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 117 MGAITALVQVCCHHSidgspvrDVVIHSSPLYGGTHALLHTFIQRWGFTHVEVNFRDPKELRDALESygdRVGLVFCETP 196
Cdd:PRK08133 86 MAAILAVVMALLQAG-------DHVVSSRSLFGSTVSLFEKIFARFGIETTFVDLTDLDAWRAAVRP---NTKLFFLETP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 197 ANPTLDMVDIRMVREIMDevfdgRRRPPLGVDNTFMG-IFQHTLLMGADVAVYSATKFLSGHSDLIAGFLVGKTGIMTVV 275
Cdd:PRK08133 156 SNPLTELADIAALAEIAH-----AAGALLVVDNCFCTpALQQPLKLGADVVIHSATKYLDGQGRVLGGAVVGSKELMEEV 230
|
...
gi 818897694 276 KPF 278
Cdd:PRK08133 231 FGF 233
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
85-278 |
5.39e-27 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 109.02 E-value: 5.39e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 85 YARLTCPAVRACEASMKALEPGaDWAFVFPSGMGAITALVqvcchhSIDGSPvrDVVIHSSPLYGGTHALLHTFIQRWGF 164
Cdd:PRK08247 46 YSRTGNPTRGVLEQAIADLEGG-DQGFACSSGMAAIQLVM------SLFRSG--DELIVSSDLYGGTYRLFEEHWKKWNV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 165 THVEVNFRDPKELRDALESygdRVGLVFCETPANPTLDMVDIRMVREIMDevfdgRRRPPLGVDNTFMG-IFQHTLLMGA 243
Cdd:PRK08247 117 RFVYVNTASLKAIEQAITP---NTKAIFIETPTNPLMQETDIAAIAKIAK-----KHGLLLIVDNTFYTpVLQRPLEEGA 188
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 818897694 244 DVAVYSATKFLSGHSDLIAGFLVGK------------TGIMTVVKPF 278
Cdd:PRK08247 189 DIVIHSATKYLGGHNDVLAGLVVAKgqelcerlayyqNAAGAVLSPF 235
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
29-268 |
3.06e-26 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 107.16 E-value: 3.06e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 29 YNPYDHD---GAVAVPNVTAATFgfrraedgeHSFgcayaieevlarlDPDgTRHMKDiYARLTCPAVRACEASMKALEP 105
Cdd:PRK08064 13 HNQYKHDkqtGAVNVPIYHASTF---------HQF-------------DFD-TFGKYD-YSRSGNPTREALEDIIAELEG 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 106 GADwAFVFPSGMGAI-TALVQVCchhsiDGspvrDVVIHSSPLYGGTHALLHTFIQRWGFTHVEVNFRDPKELRDALESy 184
Cdd:PRK08064 69 GTK-GFAFASGMAAIsTAFLLLS-----KG----DHVLISEDVYGGTYRMITEVLSRFGIEHTFVDMTNLEEVAQNIKP- 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 185 gdRVGLVFCETPANPTLDMVDIRMVREIMDEV----FdgrrrpplgVDNTFMG-IFQHTLLMGADVAVYSATKFLSGHSD 259
Cdd:PRK08064 138 --NTKLFYVETPSNPLLKVTDIRGVVKLAKAIgcltF---------VDNTFLTpLLQKPLDLGADVVLHSATKFLAGHSD 206
|
....*....
gi 818897694 260 LIAGFLVGK 268
Cdd:PRK08064 207 VLAGLAVVK 215
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
36-267 |
1.15e-25 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 106.00 E-value: 1.15e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 36 GAVAVPNVTAATFGFRRAEDGEHSfGCAYAIE--EVLARLDPDGTRHM--------KD--IYARLTCPAVRACEASMKAL 103
Cdd:PLN02242 10 PAESKEEDPAAALASARHEFGEHG-GVNMSIEasATFTVMEPDTMRRMfsgelgpdRDfyIYSRHFNPTVLNLGRQMAAL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 104 EpGADWAFVFPSGMGAITA-LVQVCCHHsidgspvrDVVIHSSPLYGGTHALLHTFIQR-WGFTHVEVNFRDPKELRDAL 181
Cdd:PLN02242 89 E-GTEAAYCTASGMSAISSvLLQLCSSG--------GHVVASNTLYGGTHALLAHFLPRkCNITTTFVDITDLEAVKKAV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 182 ESYGDRVglVFCETPANPTLDMVDIRMVREIMDEvfdgrRRPPLGVDNTFMGIFQHTLLMGADVAVYSATKFLSGHSDLI 261
Cdd:PLN02242 160 VPGKTKV--LYFESISNPTLTVADIPELARIAHE-----KGVTVVVDNTFAPMVLSPARLGADVVVHSISKFISGGADII 232
|
....*.
gi 818897694 262 AGFLVG 267
Cdd:PLN02242 233 AGAVCG 238
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
70-270 |
1.00e-24 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 102.77 E-value: 1.00e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 70 LARLDPDGTrhmkDIYARLTCPAVRACEASMKALEpgADWAFVFPSGMGAITALVQVCCHHSidgspvrDVVIHSSPLYG 149
Cdd:PRK07582 34 LSPGEPTGP----DTYGRASNPTWRALEAALGELE--GAEALVFPSGMAAITAVLRALLRPG-------DTVVVPADGYY 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 150 GTHALLHTFIQRWGFTHVEVnfRDPKELRDALesygDRVGLVFCETPANPTLDMVDIRMVREIMDevfdgRRRPPLGVDN 229
Cdd:PRK07582 101 QVRALAREYLAPLGVTVREA--PTAGMAEAAL----AGADLVLAETPSNPGLDVCDLAALAAAAH-----AAGALLVVDN 169
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 818897694 230 TFMGIF-QHTLLMGADVAVYSATKFLSGHSDLIAGFLVGKTG 270
Cdd:PRK07582 170 TTATPLgQRPLELGADLVVASDTKALTGHSDLLLGYVAGRDP 211
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
76-263 |
4.40e-23 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 98.44 E-value: 4.40e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 76 DGTRHMKDIYARLTCPAVRACEASMKALEpGADWAFVFPSGMGAITALVQVCCHHSidgspvrDVVIHSSPLYGGTHALL 155
Cdd:PRK06434 49 DSTRGMPYIYTRWGNPTVQAFEEKYAVLE-NAEHALSFSSGMGAITSAILSLIKKG-------KRILSISDLYGQTFYFF 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 156 HTFIQRWGfthVEVNFRDPKELrDALESYGDRVGLVFCETPANPTLDMVDIRMVREIMDEvfdgrrrPPLGVDNTFMGIF 235
Cdd:PRK06434 121 NKVLKTLG---IHVDYIDTDRL-NSLDFDPSNYDLIYAESITNPTLKVPDIKNVSSFCHE-------NDVIVDATFASPY 189
|
170 180
....*....|....*....|....*....
gi 818897694 236 -QHTLLMGADVAVYSATKFLSGHSDLIAG 263
Cdd:PRK06434 190 nQNPLDLGADVVIHSATKYISGHSDVVMG 218
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
85-269 |
4.61e-22 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 95.56 E-value: 4.61e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 85 YARLTCPAVRACEASMKALEPGADwAFVFPSGMGAITALVQVCCHHsidgspvrDVVIHSSPLYGGTHALLHTFIQRWGf 164
Cdd:PRK07671 44 YSRTGNPTRAALEELIAVLEGGHA-GFAFGSGMAAITAVMMLFSSG--------DHVILTDDVYGGTYRVMTKVLNRFG- 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 165 thVEVNFRDPKELRDALESYGDRVGLVFCETPANPTLDMVDIRMVREIMDEvfdgrRRPPLGVDNTFMG-IFQHTLLMGA 243
Cdd:PRK07671 114 --IEHTFVDTSNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKISTIAKE-----KGLLTIVDNTFMTpYWQSPISLGA 186
|
170 180
....*....|....*....|....*.
gi 818897694 244 DVAVYSATKFLSGHSDLIAGFLVGKT 269
Cdd:PRK07671 187 DIVLHSATKYLGGHSDVVAGLVVVNS 212
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
85-275 |
1.60e-21 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 93.74 E-value: 1.60e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 85 YARLTCPAVRACEASMKALEpGADWAFVFPSGMGAITALVQVCCHhsidgsPVRDVVIHSSpLYGGTHALLHTFIQRWGf 164
Cdd:PRK06460 39 YSREANPTVLELTKKIVELE-NAEMGVAFSSGMGAISTTALALLK------PGNSVLVHRD-MFGRSYRFFTDYLKNWG- 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 165 thVEVNFRDPKELRDALESYGDRVGLVFCETPANPTLDMVDIRMVREIMDEvfdgrRRPPLGVDNTFMG-IFQHTLLMGA 243
Cdd:PRK06460 110 --VNVDASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVVDITELSKVCKE-----NGSILIVDATFSTpINQKPLELGA 182
|
170 180 190
....*....|....*....|....*....|..
gi 818897694 244 DVAVYSATKFLSGHSDLIAGFLVGKTGIMTVV 275
Cdd:PRK06460 183 DIVVHSASKFLAGHNDVIAGLAAGYGKLLNVI 214
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
36-266 |
1.67e-21 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 94.42 E-value: 1.67e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 36 GAVAVPNVTAATFGFrraEDGEHSfgcayaieEVLARLDPDGtrHmkdIYARLTCPAVRACEASMKALEPGADwAFVFPS 115
Cdd:PRK08134 25 GARAVPIHLTTSFVF---RDSDHA--------AALFNLERAG--H---VYSRISNPTVAVLEERVAALEGGVG-AIATAS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 116 GMGA----ITALVQVCCHhsidgspvrdvVIHSSPLYGGTHALLHTFIQRWGFTHVEVNFRDPKELRDALESygdRVGLV 191
Cdd:PRK08134 88 GQAAlhlaIATLMGAGSH-----------IVASSALYGGSHNLLHYTLRRFGIETTFVKPGDIDGWRAAIRP---NTRLL 153
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 818897694 192 FCETPANPTLDMVDIRMVREIMDEvfdgrRRPPLGVDNTFMGIF-QHTLLMGADVAVYSATKFLSGHSDLIAGFLV 266
Cdd:PRK08134 154 FGETLGNPGLEVLDIPTVAAIAHE-----AGVPLLVDSTFTTPYlLRPFEHGADLVYHSATKFLGGHGTAIGGVLV 224
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
36-266 |
9.59e-21 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 92.21 E-value: 9.59e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 36 GAVAVPNVTAATFGFRraeDGEHSfgcayaieevlARLDpdGTRHMKDIYARLTCPAVRACEASMKALEPGADwAFVFPS 115
Cdd:PRK08248 25 GSRAVPIYQTTSYGFR---DSEHA-----------ANLF--SLKEFGNIYTRIMNPTTDVFEKRIAALEGGIG-ALAVSS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 116 GMGAITALVqvcchhsIDGSPVRDVVIHSSPLYGGTHALLHTFIQRWGFTHVEVNFRDPKELRDALEsygDRVGLVFCET 195
Cdd:PRK08248 88 GQAAITYSI-------LNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAAIT---DKTKALFAET 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 818897694 196 PANPTLDMVDIRMVREIMDEvfdgrRRPPLGVDNTFMGIFQ-HTLLMGADVAVYSATKFLSGHSDLIAGFLV 266
Cdd:PRK08248 158 IGNPKGDVLDIEAVAAIAHE-----HGIPLIVDNTFASPYLlRPIEHGADIVVHSATKFIGGHGTSIGGVIV 224
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
85-268 |
1.80e-20 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 91.63 E-value: 1.80e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 85 YARLTCPAVRACEASMKALEPgADWAFVFPSGMGAITALVqvcchHSIDGSpvrDVVIHSSPLYGGTHALLHTFIQRWGF 164
Cdd:PLN02509 127 YTRSGNPTRDALESLLAKLDK-ADRAFCFTSGMAALSAVT-----HLIKNG---EEIVAGDDVYGGSDRLLSQVVPRSGV 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 165 THVEVNFRDPKELRDALesyGDRVGLVFCETPANPTLDMVDIRMVREIMDEvfdgrRRPPLGVDNTFMG-IFQHTLLMGA 243
Cdd:PLN02509 198 VVKRVNTTNLDEVAAAI---GPQTKLVWLESPTNPRQQISDIRKIAEMAHA-----QGALVLVDNSIMSpVLSRPLELGA 269
|
170 180
....*....|....*....|....*
gi 818897694 244 DVAVYSATKFLSGHSDLIAGFLVGK 268
Cdd:PLN02509 270 DIVMHSATKFIAGHSDVMAGVLAVK 294
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
23-266 |
1.87e-20 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 91.47 E-value: 1.87e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 23 TTALTAYNPYDHD-GAVAVPNVTAATFGFRRAEDGEHSFGcayaieevLARLDPdgtrhmkdIYARLTCPAVRACEASMK 101
Cdd:PRK05613 16 TRSIHAGQSVDSDtSARNLPIYQTTSYVFDSAEHAKQRFA--------LEDLGP--------IYSRLTNPTVEALENRIA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 102 ALEPGADwAFVFPSGMGAITALVqvcchhsIDGSPVRDVVIHSSPLYGGTHALLHTFIQRWG--FTHVEvNFRDPKELRD 179
Cdd:PRK05613 80 SLEGGVH-AVAFASGQAAETAAI-------LNLAGAGDHIVTSPRLYGGTETLFLVTLNRLGieVTFVE-NPDDPESWQA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 180 ALEsygDRVGLVFCETPANPTLDMVDIRMVREIMDevfdgRRRPPLGVDNTF-MGIFQHTLLMGADVAVYSATKFLSGHS 258
Cdd:PRK05613 151 AVQ---PNTKAFFGETFANPQADVLDIPAVAEVAH-----RNQVPLIVDNTIaTAALVRPLELGADVVVASLTKFYTGNG 222
|
....*...
gi 818897694 259 DLIAGFLV 266
Cdd:PRK05613 223 SGLGGVLI 230
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
84-263 |
2.74e-20 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 90.58 E-value: 2.74e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 84 IYARLTCPAVRACEASMKALEpGADWAFVFPSGMGAITALVqVCchhsidgsPVR--DVVIHSSPLYGGTHALLHTFIQR 161
Cdd:PRK07504 58 IYSRYSNPTVDMFEKRMCALE-GAEDARATASGMAAVTAAI-LC--------QVKagDHVVAARALFGSCRYVVETLLPR 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 162 WGFTHVEVNFRDPKELRDALESygdRVGLVFCETPANPTLDMVDIRMVREIMDEVfdGRRrppLGVDNTFMG-IFQHTLL 240
Cdd:PRK07504 128 YGIESTLVDGLDLDNWEKAVRP---NTKVFFLESPTNPTLEVIDIAAVAKIANQA--GAK---LVVDNVFATpLFQKPLE 199
|
170 180
....*....|....*....|...
gi 818897694 241 MGADVAVYSATKFLSGHSDLIAG 263
Cdd:PRK07504 200 LGAHIVVYSATKHIDGQGRCLGG 222
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
85-278 |
2.54e-19 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 87.81 E-value: 2.54e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 85 YARLTCPAVRACEASMKALEPGADwAFVFPSGMGAITALVqvcchHSIDGSPvrDVVIHSSPLYGGTHALLHTfIQRWGF 164
Cdd:PRK08574 47 YSREENPTLRPLEEALAKLEGGVD-ALAFNSGMAAISTLF-----FSLLKAG--DRVVLPMEAYGTTLRLLKS-LEKFGV 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 165 THVEVnFRDPKELRDALESYGDRvgLVFCETPANPTLDMVDIRMVREIMDEVfdgrrRPPLGVDNTFMG-IFQHTLLMGA 243
Cdd:PRK08574 118 KVVLA-YPSTEDIIEAIKEGRTK--LVFIETMTNPTLKVIDVPEVAKAAKEL-----GAILVVDNTFATpLLYRPLRHGA 189
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 818897694 244 DVAVYSATKFLSGHSDLIAGFLVGKTGIM------------TVVKPF 278
Cdd:PRK08574 190 DFVVHSLTKYIAGHNDVVGGVAVAWSGEFleelwewrrrlgTIMQPF 236
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
36-266 |
2.66e-19 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 87.88 E-value: 2.66e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 36 GAVAVPNVTAATFGFRRAEDGEHSFGCAyaieevlarlDPDgtrhmkDIYARLTCPAVRACEASMKALEPGADwAFVFPS 115
Cdd:PRK07812 30 NARALPIYQTTSYTFDDTDHAAALFGLA----------EPG------NIYTRIMNPTQDVVEQRIAALEGGVA-ALLLAS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 116 GMGAITALVqvcchhsIDGSPVRDVVIHSSPLYGGTHALLHTFIQRWGfthVEVNF-RDPKELRDALESYGDRVGLVFCE 194
Cdd:PRK07812 93 GQAAETFAI-------LNLAGAGDHIVSSPRLYGGTYNLFHYTLPKLG---IEVSFvEDPDDLDAWRAAVRPNTKAFFAE 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 818897694 195 TPANPTLDMVDIRMVREIMDEVfdgrrRPPLGVDNT-----FMGIFQHtllmGADVAVYSATKFLSGHSDLIAGFLV 266
Cdd:PRK07812 163 TISNPQIDVLDIPGVAEVAHEA-----GVPLIVDNTiatpyLIRPLEH----GADIVVHSATKYLGGHGTAIAGVIV 230
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
29-266 |
6.19e-19 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 86.88 E-value: 6.19e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 29 YNPYDHDGAVAVPNVTAATFGFRRAEDGEHSFGCAYAieevlarldpdgtrhmKDIYARLTCPAVRACEASMKALEPGAD 108
Cdd:PRK06084 12 YSPDPTTKAVAVPIYQTTSYAFDDTQHGADLFDLKVP----------------GNIYTRIMNPTNDVLEQRVAALEGGVG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 109 wAFVFPSGMGAITALVQVCchhsidgSPVRDVVIHSSPLYGGTHALL-HTFiQRWGfthVEVNFRDPKELRdALESYGD- 186
Cdd:PRK06084 76 -ALAVASGMAAITYAIQTI-------AEAGDNIVSVAKLYGGTYNLLaHTL-PRIG---IETRFAAHDDIA-ALEALIDe 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 187 RVGLVFCETPANPTLDMVDIRMVREIMDevfdgRRRPPLGVDNT-----FMGIFQHtllmGADVAVYSATKFLSGHSDLI 261
Cdd:PRK06084 143 RTKAVFCESIGNPAGNIIDIQALADAAH-----RHGVPLIVDNTvatpvLCRPFEH----GADIVVHSLTKYIGGHGTSI 213
|
....*
gi 818897694 262 AGFLV 266
Cdd:PRK06084 214 GGIVV 218
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
85-266 |
3.44e-18 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 84.10 E-value: 3.44e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 85 YARLTCPAVRACEASMKALEpGADWAFVFPSGMGAITALvqvcchhsIDGSPVRDVVIHSSPLYGGTHallhtfiqRWgF 164
Cdd:PRK07269 48 YTRTKNPTRAKLEETLAAIE-SADYALATSSGMSAIVLA--------FSVFPVGSKVVAVRDLYGGSF--------RW-F 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 165 THVEVNFR-------DPKELRDALEsygDRVGLVFCETPANPTLDMVDIRMVREIMDEvfdgrRRPPLGVDNTFMG-IFQ 236
Cdd:PRK07269 110 NQQEKEGRfhftyanTEEELIAAIE---EDTDIVYIETPTNPLMVEFDIEKVAKLAHA-----KGAKVIVDNTFYSpIYQ 181
|
170 180 190
....*....|....*....|....*....|
gi 818897694 237 HTLLMGADVAVYSATKFLSGHSDLIAGFLV 266
Cdd:PRK07269 182 RPIELGADIVLHSATKYLSGHNDVLAGVVV 211
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
85-266 |
4.15e-17 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 81.10 E-value: 4.15e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 85 YARLTCPAVRACEASMKALEPGADwAFVFPSGMGAITALVqvcchhSIDGSpvRDVVIHSSPLYGGTHALLHTFIQRWGF 164
Cdd:PRK06176 44 YSRSGNPTRFALEELIADLEGGVK-GFAFASGLAGIHAVF------SLFQS--GDHVLLGDDVYGGTFRLFDKVLVKNGL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 165 THVEVNFRDPKELRDALESygdRVGLVFCETPANPTLDMVDIRMVREImdevfdGRRRPPLG-VDNTFMG-IFQHTLLMG 242
Cdd:PRK06176 115 SCTIIDTSDLSQIKKAIKP---NTKALYLETPSNPLLKITDLAQCASV------AKDHGLLTiVDNTFATpYYQNPLLLG 185
|
170 180
....*....|....*....|....
gi 818897694 243 ADVAVYSATKFLSGHSDLIAGFLV 266
Cdd:PRK06176 186 ADIVVHSGTKYLGGHSDVVAGLVT 209
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
85-269 |
4.54e-17 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 81.09 E-value: 4.54e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 85 YARLTCPAVRACEASMKALEPGADwAFVFPSGMGAITALVQVCChhsidgSPvRDVVIHSSPLYGGTHALLHTFIQRWGF 164
Cdd:PRK08861 47 YTRSGNPNRGLLEQTLSELESGKG-AVVTNCGTSALNLWVSALL------GP-DDLIVAPHDCYGGTYRLFNTRANKGDF 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 165 THVEVNFRDPKELRDALesyGDRVGLVFCETPANPTLDMVDIRMVREIMDEVfdgrrRPPLGVDNTFMG-IFQHTLLMGA 243
Cdd:PRK08861 119 KVQFVDQSDAAALDAAL---AKKPKLILLETPSNPLVRVVDIAELCQKAKAV-----GALVAVDNTFLTpVLQKPLELGA 190
|
170 180
....*....|....*....|....*.
gi 818897694 244 DVAVYSATKFLSGHSDLIAGFLVGKT 269
Cdd:PRK08861 191 DFVIHSTTKYINGHSDVIGGVLITKT 216
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
84-269 |
9.10e-17 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 80.16 E-value: 9.10e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 84 IYARLTCPAVRACEASMKALEpGADWAFVFPSGMGAI-TALvqvcchhsidGSPVR--DVVIHSSPLYGGTHALLHTFIQ 160
Cdd:PRK07810 63 VYSRYGNPTVSMFEERLRLIE-GAEACFATASGMSAVfTAL----------GALLGagDRLVAARSLFGSCFVVCNEILP 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 161 RWGFTHVEVNFRDPKELRDALESYGDrvgLVFCETPANPTLDMVDIRMVREIMDEVfdGRRrppLGVDNTFMG-IFQHTL 239
Cdd:PRK07810 132 RWGVETVFVDGEDLSQWEEALSVPTQ---AVFFETPSNPMQSLVDIAAVSELAHAA--GAK---VVLDNVFATpLLQRGL 203
|
170 180 190
....*....|....*....|....*....|
gi 818897694 240 LMGADVAVYSATKFLSGHSDLIAGFLVGKT 269
Cdd:PRK07810 204 PLGADVVVYSGTKHIDGQGRVLGGAILGDR 233
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
85-268 |
1.23e-16 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 80.03 E-value: 1.23e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 85 YARLTCPAVRACEASMKALEPGADwAFVFPSGMGAITALVqvcchHSIDGSPVRDVVIHSSplYGGTHALLHTFIQRWGF 164
Cdd:PRK08776 54 YTRSGNPTRDLLGEALAELEGGAG-GVITATGMGAINLVL-----NALLQPGDTLVVPHDA--YGGSWRLFNALAKKGHF 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 165 THVEVNFRDPKELRDALESygdRVGLVFCETPANPTLDMVDIRMVREIMDEVfdgrrRPPLGVDNTFMG-IFQHTLLMGA 243
Cdd:PRK08776 126 ALITADLTDPRSLADALAQ---SPKLVLIETPSNPLLRITDLRFVIEAAHKV-----GALTVVDNTFLSpALQKPLEFGA 197
|
170 180
....*....|....*....|....*
gi 818897694 244 DVAVYSATKFLSGHSDLIAGFLVGK 268
Cdd:PRK08776 198 DLVLHSTTKYINGHSDVVGGAVVAR 222
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
85-268 |
1.33e-16 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 79.94 E-value: 1.33e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 85 YARLTCPAVRACEASMKALEPGADwAFVFPSGMGAITALVQVCCHHSidgspvrDVVIHSSPLYGGTHALLHTFIQRWGF 164
Cdd:PRK08045 46 YSRRGNPTRDVVQRALAELEGGAG-AVLTNTGMSAIHLVTTVFLKPG-------DLLVAPHDCYGGSYRLFDSLAKRGCY 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 165 THVEVNFRDPKELRDALesyGDRVGLVFCETPANPTLDMVDIRMVREIMDEVfdgrrRPPLGVDNTFMG-IFQHTLLMGA 243
Cdd:PRK08045 118 RVLFVDQGDEQALRAAL---AEKPKLVLVESPSNPLLRVVDIAKICHLAREA-----GAVSVVDNTFLSpALQNPLALGA 189
|
170 180
....*....|....*....|....*
gi 818897694 244 DVAVYSATKFLSGHSDLIAGFLVGK 268
Cdd:PRK08045 190 DLVLHSCTKYLNGHSDVVAGVVIAK 214
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
79-267 |
5.59e-16 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 77.81 E-value: 5.59e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 79 RHMKDIYARLTCPAVRACEASMKALEpGADWAFVFPSGMGAITALVQvcchhSIDGSPVRDVVIHSspLYGGTHALLHTF 158
Cdd:PRK05968 51 EKVRPIYSRGDNPTVRAFEEMLAKLE-GAEDARGFASGMAAISSTVL-----SFVEPGDRIVAVRH--VYPDAFRLFETI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 159 IQRWGFTHVEVNFRDPKELRDALESygdrVGLVFCETPANPTLDMVDIRMVREImdevfdGRRRPPLGV-DNTFMG-IFQ 236
Cdd:PRK05968 123 LKRMGVEVDYVDGRDEEAVAKALPG----AKLLYLESPTSWVFELQDVAALAAL------AKRHGVVTMiDNSWASpVFQ 192
|
170 180 190
....*....|....*....|....*....|.
gi 818897694 237 HTLLMGADVAVYSATKFLSGHSDLIAGFLVG 267
Cdd:PRK05968 193 RPITLGVDLVIHSASKYLGGHSDTVAGVVAG 223
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
83-266 |
3.01e-13 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 70.13 E-value: 3.01e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 83 DIYARLTCPAVRACEASMKALEpGADWAFVFPSGMGAitalvQVCCHHSIDGSPvrDVVIHSSPLYGGT-HALLHTFiQR 161
Cdd:PRK05994 55 NIYTRITNPTNAVLEERVAALE-GGTAALAVASGHAA-----QFLVFHTLLQPG--DEFIAARKLYGGSiNQFGHAF-KS 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 162 WGFthvEVNFRDPKELRDALESYGDRVGLVFCETPANPTLDMVDIRMVREIMDevfdgRRRPPLGVDNT-----FMGIFQ 236
Cdd:PRK05994 126 FGW---QVRWADADDPASFERAITPRTKAIFIESIANPGGTVTDIAAIAEVAH-----RAGLPLIVDNTlaspyLIRPIE 197
|
170 180 190
....*....|....*....|....*....|
gi 818897694 237 HtllmGADVAVYSATKFLSGHSDLIAGFLV 266
Cdd:PRK05994 198 H----GADIVVHSLTKFLGGHGNSMGGIIV 223
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
16-265 |
1.04e-12 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 68.30 E-value: 1.04e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 16 GQAQVNNTTALTAYNPYDHDGAVAVPNVTAATFGFRRAEDGEhsfgcayaieevlarldpdgTRHMKDIYARLTCPAVRA 95
Cdd:PRK05967 9 EKAGINTRLAHDGNDPGDYHGFVNPPVVHASTVLFPDAETMA--------------------TRGQKYTYGTRGTPTTDA 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 96 CEASMKALEpGADWAFVFPSGMGAIT----ALVqvcchhsidgSPVRDVVIHSSpLYGGTHALLHTFIQRWGfthVEVNF 171
Cdd:PRK05967 69 LCKAIDALE-GSAGTILVPSGLAAVTvpflGFL----------SPGDHALIVDS-VYYPTRHFCDTMLKRLG---VEVEY 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 172 RDPkELRDALES-YGDRVGLVFCETPANPTLDMVDIRMVREIMDevfdgRRRPPLGVDNTFMG-IFQHTLLMGADVAVYS 249
Cdd:PRK05967 134 YDP-EIGAGIAKlMRPNTKVVHTEAPGSNTFEMQDIPAIAEAAH-----RHGAIVMMDNTWATpLYFRPLDFGVDISIHA 207
|
250
....*....|....*.
gi 818897694 250 ATKFLSGHSDLIAGFL 265
Cdd:PRK05967 208 ATKYPSGHSDILLGTV 223
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
36-266 |
2.61e-11 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 63.94 E-value: 2.61e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 36 GAVAVPNVTAATFGFRRAEDgehsfgcayaIEEVLARLDPDGTrhmkdiYARLTCPAVRACEASMKALEPGADwAFVFPS 115
Cdd:PRK05939 8 GAVHKPIHTSVTYGYEDARD----------LIDVFQGKKPGFT------YARQGTPTTAALEAKITKMEGGVG-TVCFAT 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 116 GMGAITALVQVCCHHSidgspvrDVVIHSSPLYGGTHALLHTfIQRWGfthVEVNFRDPKELRDALESYGDRVGLVFCET 195
Cdd:PRK05939 71 GMAAIAAVFLTLLRAG-------DHLVSSQFLFGNTNSLFGT-LRGLG---VEVTMVDATDVQNVAAAIRPNTRMVFVET 139
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 818897694 196 PANPTLDMVDIRMVREIMDEvfdgrRRPPLGVDNTFMG--IFQhTLLMGADVAVYSATKFLSGHSDLIAGFLV 266
Cdd:PRK05939 140 IANPGTQVADLAGIGALCRE-----RGLLYVVDNTMTSpwLFR-PKDVGASLVINSLSKYIAGHGNALGGAVT 206
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
91-263 |
5.84e-07 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 50.49 E-value: 5.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 91 PAVRACEASMKALEpGADWAFVFPSGMGAITaLVQVCCHHSIDgspvrDVVIHSSpLYGGTHALLHTFIQRWGfthVEVN 170
Cdd:PRK07050 65 PTSLALAQRLAEIE-GGRHALLQPSGLAAIS-LVYFGLVKAGD-----DVLIPDN-AYGPNRDHGEWLARDFG---ITVR 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 171 FRDPKELRDALESYGDRVGLVFCETPANPTLDMVDIRMVREIMDEvfdgrRRPPLGVDNTF-MGIFQHTLLMGADVAVYS 249
Cdd:PRK07050 134 FYDPLIGAGIADLIQPNTRLIWLEAPGSVTMEVPDVPAITAAARA-----RGVVTAIDNTYsAGLAFKPFEHGVDISVQA 208
|
170
....*....|....
gi 818897694 250 ATKFLSGHSDLIAG 263
Cdd:PRK07050 209 LTKYQSGGSDVLMG 222
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
95-266 |
1.33e-05 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 46.23 E-value: 1.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 95 ACEASMKALEPGADWAFvFPSGMGAIT----ALVQVCCHhsidgspvrdvVIHSSPLYGGTHALLHTFIQRWGfthVEVN 170
Cdd:PRK08114 66 SLQEAMCELEGGAGCAL-YPCGAAAVAnailAFVEQGDH-----------VLMTGTAYEPTQDFCSKILSKLG---VTTT 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 171 FRDPKELRDALESYGDRVGLVFCETPANPTLDMVDI----RMVREIMDEVFdgrrrppLGVDNTFM-GIFQHTLLMGADV 245
Cdd:PRK08114 131 WFDPLIGADIAKLIQPNTKVVFLESPGSITMEVHDVpaivAAVRSVNPDAV-------IMIDNTWAaGVLFKALDFGIDI 203
|
170 180
....*....|....*....|.
gi 818897694 246 AVYSATKFLSGHSDLIAGFLV 266
Cdd:PRK08114 204 SIQAGTKYLVGHSDAMIGTAV 224
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
85-263 |
4.17e-04 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 41.64 E-value: 4.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 85 YARLTCPAVRACEASMKALEPGADWAfVFPSGMGAITALVQvcchhsidgSPVR--DVVIHSSPLYGGTHALLHTFIQRW 162
Cdd:PRK09028 55 YGRRGTPTHFAFQAAIVELEGGAGTA-LYPSGAAAISNALL---------SFLKagDHLLMVDSCYEPTRDLCDKILKGF 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 163 GfthVEVNFRDPKELRDALESYGDRVGLVFCETPANPTLDMVDIRMVREIMDE----VFdgrrrpplgVDNTF-MGIFQH 237
Cdd:PRK09028 125 G---IETTYYDPMIGEGIRELIRPNTKVLFLESPGSITMEVQDVPTLSRIAHEhdivVM---------LDNTWaSPINSR 192
|
170 180
....*....|....*....|....*.
gi 818897694 238 TLLMGADVAVYSATKFLSGHSDLIAG 263
Cdd:PRK09028 193 PFEMGVDISIQAATKYIVGHSDVMLG 218
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
97-256 |
4.78e-04 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 40.44 E-value: 4.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 97 EASMKALEPGADWAFVFPSGMGAITALVQvcchhSIDGSpvRDVVIHSSPLYGGTHAllhTFIQRWGFTHVEVNF----- 171
Cdd:cd01494 7 EKLARLLQPGNDKAVFVPSGTGANEAALL-----ALLGP--GDEVIVDANGHGSRYW---VAAELAGAKPVPVPVddagy 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 172 --RDPKELRDALEsyGDRVGLVFCETPANPTLDMVDIRMVREIMDEVFDgrrrpPLGVDNTFMG-----IFQHTLLMGAD 244
Cdd:cd01494 77 ggLDVAILEELKA--KPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGI-----LLLVDAASAGgaspaPGVLIPEGGAD 149
|
170
....*....|..
gi 818897694 245 VAVYSATKFLSG 256
Cdd:cd01494 150 VVTFSLHKNLGG 161
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
103-267 |
6.76e-03 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 37.71 E-value: 6.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 103 LEPGADWAFVFPSGMGAITALVQVCCHHSidgspvrDVVIHSSPLYGGthalLHTFIQRWGFTHVEV----NFRDPKELR 178
Cdd:cd00609 55 VDVPPEEIVVTNGAQEALSLLLRALLNPG-------DEVLVPDPTYPG----YEAAARLAGAEVVPVpldeEGGFLLDLE 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818897694 179 DALESYGDRVGLVFCETPANPT---LDMVDIRMVREIM---------DEV-----FDGRRRPPLgvdnTFMGIFQHTLLM 241
Cdd:cd00609 124 LLEAAKTPKTKLLYLNNPNNPTgavLSEEELEELAELAkkhgiliisDEAyaelvYDGEPPPAL----ALLDAYERVIVL 199
|
170 180
....*....|....*....|....*.
gi 818897694 242 GadvavySATKFLsGHSDLIAGFLVG 267
Cdd:cd00609 200 R------SFSKTF-GLPGLRIGYLIA 218
|
|
| |
