|
Name |
Accession |
Description |
Interval |
E-value |
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
13-510 |
7.62e-106 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 326.34 E-value: 7.62e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 13 LSAAFIIMATYGLSHLIGLVKTrLLISSFFSAqSQLLDVYYAAFVIPDTIFQLLVIGSLSAAFIPTFSKYLAK-DEKEAW 91
Cdd:COG0728 1 LRAALIVAIGTLLSRILGFVRD-ILIAAAFGA-GAVADAFFVAFRIPNLLRRLFAEGALSAAFVPVLAEALEKeGEEEAR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 92 TMTSTTMNLIILIFMLLSALIFVFAYPLSRLIAPGFTAFQIGTMVQLLRIMLVAQIFFSISGFLTGIIQSHQRFLIPALA 171
Cdd:COG0728 79 RFASRVLTLLLLVLLVLTLLGILFAPLLVKLLAPGFDPEKFALAVALTRIMFPYILFIGLSALLGGVLNARGRFAAPALA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 172 PVAYNLGIIAGIVFLSPTL--GILGPAWGVVLGAVLHMLIQLPLAWRLGFRPSLSLNFSHPGVREVGRLMPPRVLALGID 249
Cdd:COG0728 159 PVLLNLVIIAGLLLLAPLFgpGIYALAWGVLLGGVLQLLIQLPALRRLGLRLRPRFDLRDPGVRRVLKLMLPALLGVSVS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 250 QIEQFVAVTLASLLVPGSLSLLNAARLLFTIPTSLFGVTISQAAFPQLAKEAAHSNLDQFRSTLISSFLQIAFMALPLST 329
Cdd:COG0728 239 QINLLVDTILASFLPEGSVSALYYADRLYQLPLGLFGVAIGTALLPRLSRAAAAGDLEEFRRTLSRGLRLVLLLTLPAAV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 330 LFIILRIPIVRLIFGAKTFPWAATLLTGKTLAILCASAAFYAVMQLVIRGFYALHDTRTPLLVGFLAAIFSSLLAVFSVT 409
Cdd:COG0728 319 GLIVLAEPIVRLLFERGAFTAEDTALTALALAAYALGLPAFALVKVLARAFYARQDTRTPVRIAVIAVVVNIVLNLLLVP 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 410 WLgwGILGIAVAISATAILETLVLSWLLYRRVSVAPHK-VFVPLAKMILTSLITGLFLWLPMRLLDEFVFDTTRTLPLLL 488
Cdd:COG0728 399 PL--GHAGLALATSLSALVNALLLLVLLRRRLGGLPLRgILRTLLKLLLASLVMGAVLWLLLRLLGDWLGGGLLGRLLAL 476
|
490 500
....*....|....*....|..
gi 818798794 489 LTGITTLIGlsVYFFLSVVFKI 510
Cdd:COG0728 477 ALLILVGAA--VYFALLLLLGV 496
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
20-440 |
1.88e-104 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 320.17 E-value: 1.88e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 20 MATYGLSHLIGLVKTrLLISSFFSAqSQLLDVYYAAFVIPDTIFQLLVIGSLSAAFIPTFSKYLAK-DEKEAWTMTSTTM 98
Cdd:cd13123 1 AIGTLLSRILGFVRD-VLIAAAFGA-GPLADAFFVAFRIPNLLRRLFAEGALSAAFVPVFSEYLEKeGEEEARRFASRVL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 99 NLIILIFMLLSALIFVFAYPLSRLIAPGFTAFQIGTMVQLLRIMLVAQIFFSISGFLTGIIQSHQRFLIPALAPVAYNLG 178
Cdd:cd13123 79 TLLLLVLLLLTLLGILFAPLLVKLLAPGFSGDKFELAVALTRIMFPYLLFISLSALLGGILNAHGRFFAPALAPVLLNLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 179 IIAGIVFLSPTL--GILGPAWGVVLGAVLHMLIQLPLAWRLGFRPSLSLNFSHPGVREVGRLMPPRVLALGIDQIEQFVA 256
Cdd:cd13123 159 IIAGLLLLAPLFdlGIYALAWGVLLGGVLQLLVQLPALRRLGFRFRPRLDFRDPGVRRVLKLMLPALLGVSVSQINLLVD 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 257 VTLASLLVPGSLSLLNAARLLFTIPTSLFGVTISQAAFPQLAKEAAHSNLDQFRSTLISSFLQIAFMALPLSTLFIILRI 336
Cdd:cd13123 239 TILASFLPEGSISALYYADRLYQLPLGIFGVAIATALLPRLSRLAAAGDLDEFRRTLSRGLRLVLFLLLPAAVGLIVLAE 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 337 PIVRLIFGAKTFPWAATLLTGKTLAILCASAAFYAVMQLVIRGFYALHDTRTPLLVGFLAAIFSSLLAVFSVTWlgWGIL 416
Cdd:cd13123 319 PIVRLLFERGAFTAEDTLMTASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKIAVIAVAVNILLNLLLIKP--LGHV 396
|
410 420
....*....|....*....|....
gi 818798794 417 GIAVAISATAILETLVLSWLLYRR 440
Cdd:cd13123 397 GLALATSLSAWVNALLLLVLLRRR 420
|
|
| murJ_mviN |
TIGR01695 |
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously ... |
25-468 |
5.55e-60 |
|
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273763 [Multi-domain] Cd Length: 502 Bit Score: 206.41 E-value: 5.55e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 25 LSHLIGLVKTrLLISSFFSAqSQLLDVYYAAFVIPDTIFQLLVIGSLSAAFIPTFSKYLAKDEKEAWTMTSTTMNLIILI 104
Cdd:TIGR01695 15 FSRITGFVRD-AIIASAFGA-GLTADAFNVAFVIPNFFRRLFAEGAFNSAFVPVFTKAKKKEKEARRAFANTVTTLLILS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 105 FMLLSALIFVFAYPLSRLIAPGFTAFQIGTMVQLLRIMLVAQIFFSISGFLTGIIQSHQRFLIPALAPVAYNLGIIAGIV 184
Cdd:TIGR01695 93 LLLVVLIGIFFAPFVISLLAPGFADETRSLAVSLTRIMFPYLLLISLAAVFGGILNARKRFFIPSFSPILFNIGVILSLL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 185 FLSPTLGILG--PAWGVVLGAVLHMLIQLPLAWRLGFRPSLSLNFSHPGVREVGRLMPPRVLALGIDQIEQFVAVTLASL 262
Cdd:TIGR01695 173 FFDWNYGQYSlaLAIGVLIGGVAQLLIQLPFLRKAGFLLKPRFNFRDPGLKRFLKLFLPTTLGSSASQITLLINTALASF 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 263 LVPGSLSLLNAARLLFTIPTSLFGVTISQAAFPQLAKEAAHSNLDQFRSTLISSFLQIAFMALPLSTLFIILRIPIVRLI 342
Cdd:TIGR01695 253 LEIGSVSALYYANRIYQLPLGIFGISLSTVLLPKLSRHASEGNWNELRDLLNQGIRLSLLLTIPSSFGLLILSIPIVSLL 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 343 FGAKTFPWAATLLTGKTLAILCASAAFYAVMQLVIRGFYALHDTRTPLLVGFLAAIFSSLLAVFSVTWLGWGilGIAVAI 422
Cdd:TIGR01695 333 FERGAFSEEDTVMTATILAAYGLGLIFYSLQKVLLRAFYARKDTRTPFINSVISVVLNALLSLLLIFPLGLV--GIALAT 410
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 818798794 423 SATAILETLVLSWLLYRRVSVAPH-KVFVPLAKMILTSLITGLFLWL 468
Cdd:TIGR01695 411 SAASMVSSVLLYLMLNRRLKGILPfGVLKVLAKLVIASAIIGGVLYL 457
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
38-477 |
1.59e-57 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 198.67 E-value: 1.59e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 38 ISSFFSAqSQLLDVYYAAFVIPDTIFQLLVIGSLSAAFIPTFSKYLAKDEKEAWTMTSTTMNLIILIFMLLSALIFVFAY 117
Cdd:pfam03023 1 IAAYFGA-GLLSDAFNVAFKIPNLLRRLFAEGAFSSAFIPVLAELKAQDKEEAAEFVRKVSTLLILVLLLVTLIGILAAP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 118 PLSRLIAPGFTAFQIGTMVQLLRIMLVAQIFFSISGFLTGIIQSHQRFLIPALAPVAYNLGIIAGIVFLSPTLG--ILGP 195
Cdd:pfam03023 80 WLIRLLAPGFDPETFSLAVSLLRITFPYLLLVSLSAVFGAVLNARKKFFAPSFSPVLLNVGVILTLLLLANYLGnaIYAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 196 AWGVVLGAVLHMLIQLPLAWRLGFRPSLSLNFSHPGVREVGRLMPPRVLALGIDQIEQFVAVTLASLLVPGSLSLLNAAR 275
Cdd:pfam03023 160 AIGVLIGGVLQLLVQLPFLKKAGLLLKPRFGFRDKGLKRFLKLMLPTLLGVSVSQLNLLIDTFLASFLAPGSVSYLYYAD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 276 LLFTIPTSLFGVTISQAAFPQLAKEAAHSNLDQFRSTLISSFLQIAFMALPLSTLFIILRIPIVRLIFGAKTFPWAATLL 355
Cdd:pfam03023 240 RIYQLPLGIFGVSISTVLLPRLSRHAADGDWDEFRDLLDQAIRLTLLLMIPVSFGLLVLSIPIVSLLFERGNFSPEDVTA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 356 TGKTLAILCASAAFYAVMQLVIRGFYALHDTRTPLLVGFLAAIFSSLLAVFSVtwLGWGILGIAVAISATAILETLVLSW 435
Cdd:pfam03023 320 TAEVLAAYALGLIPYALVKLLSRVFYAREDTKTPFKISLISAVLNILLSLLLL--PPLGVAGLALATSLSSLIGLVFLYY 397
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 818798794 436 LLYRRVSVAPHKVF--VPLAKMILTSLITGLFLWLPMRLLDEFV 477
Cdd:pfam03023 398 ILRKRLGGFDLRGIktFLASLVVPTALMAGVILLLSSLTQGPWV 441
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
13-510 |
7.62e-106 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 326.34 E-value: 7.62e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 13 LSAAFIIMATYGLSHLIGLVKTrLLISSFFSAqSQLLDVYYAAFVIPDTIFQLLVIGSLSAAFIPTFSKYLAK-DEKEAW 91
Cdd:COG0728 1 LRAALIVAIGTLLSRILGFVRD-ILIAAAFGA-GAVADAFFVAFRIPNLLRRLFAEGALSAAFVPVLAEALEKeGEEEAR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 92 TMTSTTMNLIILIFMLLSALIFVFAYPLSRLIAPGFTAFQIGTMVQLLRIMLVAQIFFSISGFLTGIIQSHQRFLIPALA 171
Cdd:COG0728 79 RFASRVLTLLLLVLLVLTLLGILFAPLLVKLLAPGFDPEKFALAVALTRIMFPYILFIGLSALLGGVLNARGRFAAPALA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 172 PVAYNLGIIAGIVFLSPTL--GILGPAWGVVLGAVLHMLIQLPLAWRLGFRPSLSLNFSHPGVREVGRLMPPRVLALGID 249
Cdd:COG0728 159 PVLLNLVIIAGLLLLAPLFgpGIYALAWGVLLGGVLQLLIQLPALRRLGLRLRPRFDLRDPGVRRVLKLMLPALLGVSVS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 250 QIEQFVAVTLASLLVPGSLSLLNAARLLFTIPTSLFGVTISQAAFPQLAKEAAHSNLDQFRSTLISSFLQIAFMALPLST 329
Cdd:COG0728 239 QINLLVDTILASFLPEGSVSALYYADRLYQLPLGLFGVAIGTALLPRLSRAAAAGDLEEFRRTLSRGLRLVLLLTLPAAV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 330 LFIILRIPIVRLIFGAKTFPWAATLLTGKTLAILCASAAFYAVMQLVIRGFYALHDTRTPLLVGFLAAIFSSLLAVFSVT 409
Cdd:COG0728 319 GLIVLAEPIVRLLFERGAFTAEDTALTALALAAYALGLPAFALVKVLARAFYARQDTRTPVRIAVIAVVVNIVLNLLLVP 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 410 WLgwGILGIAVAISATAILETLVLSWLLYRRVSVAPHK-VFVPLAKMILTSLITGLFLWLPMRLLDEFVFDTTRTLPLLL 488
Cdd:COG0728 399 PL--GHAGLALATSLSALVNALLLLVLLRRRLGGLPLRgILRTLLKLLLASLVMGAVLWLLLRLLGDWLGGGLLGRLLAL 476
|
490 500
....*....|....*....|..
gi 818798794 489 LTGITTLIGlsVYFFLSVVFKI 510
Cdd:COG0728 477 ALLILVGAA--VYFALLLLLGV 496
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
20-440 |
1.88e-104 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 320.17 E-value: 1.88e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 20 MATYGLSHLIGLVKTrLLISSFFSAqSQLLDVYYAAFVIPDTIFQLLVIGSLSAAFIPTFSKYLAK-DEKEAWTMTSTTM 98
Cdd:cd13123 1 AIGTLLSRILGFVRD-VLIAAAFGA-GPLADAFFVAFRIPNLLRRLFAEGALSAAFVPVFSEYLEKeGEEEARRFASRVL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 99 NLIILIFMLLSALIFVFAYPLSRLIAPGFTAFQIGTMVQLLRIMLVAQIFFSISGFLTGIIQSHQRFLIPALAPVAYNLG 178
Cdd:cd13123 79 TLLLLVLLLLTLLGILFAPLLVKLLAPGFSGDKFELAVALTRIMFPYLLFISLSALLGGILNAHGRFFAPALAPVLLNLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 179 IIAGIVFLSPTL--GILGPAWGVVLGAVLHMLIQLPLAWRLGFRPSLSLNFSHPGVREVGRLMPPRVLALGIDQIEQFVA 256
Cdd:cd13123 159 IIAGLLLLAPLFdlGIYALAWGVLLGGVLQLLVQLPALRRLGFRFRPRLDFRDPGVRRVLKLMLPALLGVSVSQINLLVD 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 257 VTLASLLVPGSLSLLNAARLLFTIPTSLFGVTISQAAFPQLAKEAAHSNLDQFRSTLISSFLQIAFMALPLSTLFIILRI 336
Cdd:cd13123 239 TILASFLPEGSISALYYADRLYQLPLGIFGVAIATALLPRLSRLAAAGDLDEFRRTLSRGLRLVLFLLLPAAVGLIVLAE 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 337 PIVRLIFGAKTFPWAATLLTGKTLAILCASAAFYAVMQLVIRGFYALHDTRTPLLVGFLAAIFSSLLAVFSVTWlgWGIL 416
Cdd:cd13123 319 PIVRLLFERGAFTAEDTLMTASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKIAVIAVAVNILLNLLLIKP--LGHV 396
|
410 420
....*....|....*....|....
gi 818798794 417 GIAVAISATAILETLVLSWLLYRR 440
Cdd:cd13123 397 GLALATSLSAWVNALLLLVLLRRR 420
|
|
| murJ_mviN |
TIGR01695 |
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously ... |
25-468 |
5.55e-60 |
|
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273763 [Multi-domain] Cd Length: 502 Bit Score: 206.41 E-value: 5.55e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 25 LSHLIGLVKTrLLISSFFSAqSQLLDVYYAAFVIPDTIFQLLVIGSLSAAFIPTFSKYLAKDEKEAWTMTSTTMNLIILI 104
Cdd:TIGR01695 15 FSRITGFVRD-AIIASAFGA-GLTADAFNVAFVIPNFFRRLFAEGAFNSAFVPVFTKAKKKEKEARRAFANTVTTLLILS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 105 FMLLSALIFVFAYPLSRLIAPGFTAFQIGTMVQLLRIMLVAQIFFSISGFLTGIIQSHQRFLIPALAPVAYNLGIIAGIV 184
Cdd:TIGR01695 93 LLLVVLIGIFFAPFVISLLAPGFADETRSLAVSLTRIMFPYLLLISLAAVFGGILNARKRFFIPSFSPILFNIGVILSLL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 185 FLSPTLGILG--PAWGVVLGAVLHMLIQLPLAWRLGFRPSLSLNFSHPGVREVGRLMPPRVLALGIDQIEQFVAVTLASL 262
Cdd:TIGR01695 173 FFDWNYGQYSlaLAIGVLIGGVAQLLIQLPFLRKAGFLLKPRFNFRDPGLKRFLKLFLPTTLGSSASQITLLINTALASF 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 263 LVPGSLSLLNAARLLFTIPTSLFGVTISQAAFPQLAKEAAHSNLDQFRSTLISSFLQIAFMALPLSTLFIILRIPIVRLI 342
Cdd:TIGR01695 253 LEIGSVSALYYANRIYQLPLGIFGISLSTVLLPKLSRHASEGNWNELRDLLNQGIRLSLLLTIPSSFGLLILSIPIVSLL 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 343 FGAKTFPWAATLLTGKTLAILCASAAFYAVMQLVIRGFYALHDTRTPLLVGFLAAIFSSLLAVFSVTWLGWGilGIAVAI 422
Cdd:TIGR01695 333 FERGAFSEEDTVMTATILAAYGLGLIFYSLQKVLLRAFYARKDTRTPFINSVISVVLNALLSLLLIFPLGLV--GIALAT 410
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 818798794 423 SATAILETLVLSWLLYRRVSVAPH-KVFVPLAKMILTSLITGLFLWL 468
Cdd:TIGR01695 411 SAASMVSSVLLYLMLNRRLKGILPfGVLKVLAKLVIASAIIGGVLYL 457
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
38-477 |
1.59e-57 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 198.67 E-value: 1.59e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 38 ISSFFSAqSQLLDVYYAAFVIPDTIFQLLVIGSLSAAFIPTFSKYLAKDEKEAWTMTSTTMNLIILIFMLLSALIFVFAY 117
Cdd:pfam03023 1 IAAYFGA-GLLSDAFNVAFKIPNLLRRLFAEGAFSSAFIPVLAELKAQDKEEAAEFVRKVSTLLILVLLLVTLIGILAAP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 118 PLSRLIAPGFTAFQIGTMVQLLRIMLVAQIFFSISGFLTGIIQSHQRFLIPALAPVAYNLGIIAGIVFLSPTLG--ILGP 195
Cdd:pfam03023 80 WLIRLLAPGFDPETFSLAVSLLRITFPYLLLVSLSAVFGAVLNARKKFFAPSFSPVLLNVGVILTLLLLANYLGnaIYAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 196 AWGVVLGAVLHMLIQLPLAWRLGFRPSLSLNFSHPGVREVGRLMPPRVLALGIDQIEQFVAVTLASLLVPGSLSLLNAAR 275
Cdd:pfam03023 160 AIGVLIGGVLQLLVQLPFLKKAGLLLKPRFGFRDKGLKRFLKLMLPTLLGVSVSQLNLLIDTFLASFLAPGSVSYLYYAD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 276 LLFTIPTSLFGVTISQAAFPQLAKEAAHSNLDQFRSTLISSFLQIAFMALPLSTLFIILRIPIVRLIFGAKTFPWAATLL 355
Cdd:pfam03023 240 RIYQLPLGIFGVSISTVLLPRLSRHAADGDWDEFRDLLDQAIRLTLLLMIPVSFGLLVLSIPIVSLLFERGNFSPEDVTA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 356 TGKTLAILCASAAFYAVMQLVIRGFYALHDTRTPLLVGFLAAIFSSLLAVFSVtwLGWGILGIAVAISATAILETLVLSW 435
Cdd:pfam03023 320 TAEVLAAYALGLIPYALVKLLSRVFYAREDTKTPFKISLISAVLNILLSLLLL--PPLGVAGLALATSLSSLIGLVFLYY 397
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 818798794 436 LLYRRVSVAPHKVF--VPLAKMILTSLITGLFLWLPMRLLDEFV 477
Cdd:pfam03023 398 ILRKRLGGFDLRGIktFLASLVVPTALMAGVILLLSSLTQGPWV 441
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
61-438 |
9.20e-14 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 72.96 E-value: 9.20e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 61 TIFQLLVIGSLSAAFIptfsKYLAKDEKEawtMTSTTMNLIILIFMLLSALIFVFAYplsrlIAPGFTAFQIGTMVQLLR 140
Cdd:cd13128 46 GLFSIFADLGLPTALV----REIARYRKE---KIREIISTSLVLKLILGILALLLLF-----LFAFLIAFYDPELVLLLY 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 141 IMLVAQIFFSISGFLTGIIQSHQRFLIPALA-PVAYNLGIIAGIVFLSPTLGILGPAWGVVLGAVLHMLIQLpLAWRLGF 219
Cdd:cd13128 114 ILALSLPFSALNSLFRGIFQGFEKMKYIVIArIIESVLSLILALILVLLGGGLIGFALAYLIASVLSAILLL-YIYRKKI 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 220 RPSLSLNFSHPGVREVGR----LMPPRVLALGIDQIEQFVavtLASLLVPGSLSLLNAARLLFTIPTsLFGVTISQAAFP 295
Cdd:cd13128 193 LLPKFFSFDLKLAKELLRfsipLALSGIFSLIYTRIDTIM---LGYFLGDAAVGIYNAAYRIAELLL-FIPSAISTALFP 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 296 QLAKeAAHSNLDQFRSTLISSFLQIAFMALPLSTLFIILRIPIVRLIFGAKtFPWAATlltgkTLAILCASAAFYAVMQL 375
Cdd:cd13128 269 RISE-LYKNDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEE-YLPAAL-----VLQILAWGFLFIFLNGI 341
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 818798794 376 VIRGFYALHDTRTPLLVGFLAAIFSSLLAVFSVTwlGWGILGIAVAISATAILETLVLSWLLY 438
Cdd:cd13128 342 FGSILQAIGKQKLTLKILLIGALLNVILNLLLIP--KYGIIGAAIATLISEFIIFILLLYLLK 402
|
|
| MATE_tuaB_like |
cd13127 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
84-443 |
2.57e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240532 [Multi-domain] Cd Length: 406 Bit Score: 71.75 E-value: 2.57e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 84 AKDEKEAWTMTSTTMNLIILIfmLLSALIFVFAYPLSRLiapgftaFQIGTMVQLLRIMLVAQIFFSISGFLTGIIQSHQ 163
Cdd:cd13127 63 RKDLTEEDLSTVFWLNLLLGL--LLYLLLFLLAPLIAAF-------YNEPELIPLLRVLSLSFLLSGLGSVPRALLQREL 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 164 RFLIPALAPVAYNL-GIIAGIVFLSPTLGIlgpaWGVVLGAVLHMLIQLPLAWRLGfRPSLSLNFSHPGVREV----GRL 238
Cdd:cd13127 134 RFKKLAIIELISTLvSGVVAIVLALLGFGV----WALVAQQLVGALVSTVLLWILS-RWRPRLSFSLASLKELlsfgSKL 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 239 MPPRVLALGIDQIEQFVavtLASLLVPGSLSLLNAARLLFTIPTSLFGVTISQAAFPQLAKeaAHSNLDQFRSTLISSFL 318
Cdd:cd13127 209 LGSNLLNYFSRNLDNLI---IGKFLGAAALGYYSRAYRLALLPVQNITGPITRVLFPALSR--LQDDPERLRRAYLKALR 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 319 QIAFMALPLSTLFIILRIPIVRLIFGAKtfpWAATLLTgktLAILCASAAFYAVMQLVIRGFYALHDTRTPLLVGFLAAI 398
Cdd:cd13127 284 LLALITFPLMVGLALLAEPLVLLLLGEK---WLPAVPI---LQILALAGLFQPLSSLNGSLLLALGRTDLLLKLGLIKAV 357
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 818798794 399 FSSLLAVFSVTWlgwGILGIAVAISATAILETLVLSWLLYRRVSV 443
Cdd:cd13127 358 LTVLALLIGIPY---GIIGVAIAYVIASLLSFPLNLYLAGRLIGI 399
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
46-433 |
2.01e-11 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 65.81 E-value: 2.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 46 SQLLDVYYAAF--VIPDTIFQLLVIGSLSAAFIPTFSKYLAKDEKEAWTMTSTTMNLIILIFMLLSALIFVFAYPLSRLI 123
Cdd:cd12082 23 GRLLGDALAAVglAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVLAILLGLLLAALLLFFSPLILSL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 124 ApGFTAFQIGTMVQLLRIMLVAQIFFSISGFLTGIIQSHQRFLIPALAPVaynLGIIAGIVFL--------SPTLGILGP 195
Cdd:cd12082 103 L-GAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISV---LSNLLNILLDpllifglgPPELGIAGA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 196 AWGVVLGAVLHMLIQLPLAWRLGFRPSLSLNFSHPGVREVGRLMPPRVLALGIDQIEQFVAVTLASLLV----PGSLSLL 271
Cdd:cd12082 179 ALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGLLIIVAIVAafggAAALAAY 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 272 NAARLLFTIpTSLFGVTISQAAFPQLAKEAAHSNLDQFRSTLISSFLQIAFMALPLSTLFIILRIPIVRLIFGAKTFPWA 351
Cdd:cd12082 259 TVAFRIASL-AFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLILLFPEPILSLFTNDPEFLEL 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 352 ATLLtgktLAILCASAAFYAVMQLVIRGFYALHDTRTPLLVGFLAAIFSSLLAVFSVTWLGWGILGIAVAISATAILETL 431
Cdd:cd12082 338 AVSY----LRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAYLGLGLYGIWLALVISLILAAL 413
|
..
gi 818798794 432 VL 433
Cdd:cd12082 414 VL 415
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
71-436 |
1.26e-10 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 63.62 E-value: 1.26e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 71 LSAAFIPTFSKYL-AKDEKEAWTMTSTTMNLIILIFMLLSALIFVFAYPLSRLIAPGFTAFQIGtmVQLLRIMLVAQIFF 149
Cdd:COG0534 63 LGVGGTALVAQALgAGDREEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALA--RDYLRIILLGLPFL 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 150 SISGFLTGIIQSHQRFLIPALAPVAYN-LGIIAGIVF-LSPTLGILGPAWGVVLGAVLHMLIQLPLAWRLGFRPSLSLNF 227
Cdd:COG0534 141 LLFNVLNGILRGLGDTKTPMIIMLIGNvLNIVLDPLLiFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRD 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 228 SHPGVREVGRLmpprvLALGIDQIEQFVAVTLASLLVPGSLSLL--------NAARLLFTIpTSLFGVTISQAAFPQLAK 299
Cdd:COG0534 221 LRPDRKILKRI-----LRIGLPAGLQQLAESLGFLVLNALVARLgtaavaayGIALRIESL-AFMPALGLGQAAQPLVGQ 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 300 EAAHSNLDQFRSTLISSFLQIAFMALPLSTLFIILRIPIVRLiFGAKTfpwAATLLTGKTLAILCASAAFYAVMQLVIRG 379
Cdd:COG0534 295 NLGAGDYDRARRAARLALLLALGIGLLLALLLFLFPEPIIGL-FTDDP---EVIALAATYLRIAALFQPFDGLQFVLSGA 370
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 818798794 380 FYALHDTRTPLLVGFLAAIFSSLLAVFSVTWLGWGILGIAVAISATAILETLVLSWL 436
Cdd:COG0534 371 LRGAGDTRFPMIISLLRLWLVRLPLAYLLAFLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
10-433 |
3.08e-08 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 55.73 E-value: 3.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 10 SHILSAAFIIMATYGLSHLIGLVKTRLLISSFFSAQSQLLDVYYAAFvipdTIFQLLVIGSLSAAFIPTFSKYLAKDEKE 89
Cdd:COG2244 2 KKLLKNTLWLLLGQLLGALLGFLLLPLLARLLGPEEYGLFALALSIV----ALLSVLADLGLSTALVRFIAEYREEELRR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 90 AWtmtSTTMNLIILIFMLLSALIFVFAYPLSRLiapgftaFQIGTMVQLLRIMLVAQIFFSISGFLTGIIQSHQRFLIPA 169
Cdd:COG2244 78 LL---STALLLRLLLSLLLALLLLLLAPFIAAL-------LGEPELALLLLLLALALLLSALSAVLLALLRGLERFKLLA 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 170 LAPVAYNLGIIAGIVFLsptLGILGPAWGVVLgavlhmliqlplawrlgfrpslslnfshpgvREVGRLMPPRVLALGID 249
Cdd:COG2244 148 LINILSSLLSLLLALLL---ALLGLGLWGLVL-------------------------------KYSLPLLLSGLLGLLLT 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 250 QIEQFVavtLASLLVPGSLSLLNAARLLFTIPTsLFGVTISQAAFPQLAKEAAHSNLDQFRSTLISSFLQIAFMALPLST 329
Cdd:COG2244 194 NLDRLL---LGALLGPAAVGIYSAAYRLASLLL-LLITALSQVLFPRLSRLLAEGDREELRRLYRKALRLLLLLGLPLAL 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 330 LFIILRIPIVRLIFGAKTFPwaatllTGKTLAILCASAAFYAVMQLVIRGFYALHDTRTPLLVGFLAAIFSSLLAVFSVT 409
Cdd:COG2244 270 GLALLAPPLLSLLFGPEYAE------AAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAVLNLVLNLLLIP 343
|
410 420
....*....|....*....|....
gi 818798794 410 WlgWGILGIAVAISATAILETLVL 433
Cdd:COG2244 344 R--YGLVGAAIATLLSYLVLLLLL 365
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
31-211 |
1.61e-07 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 53.63 E-value: 1.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 31 LVKTRLLISSFFSAQSQLLDVYYAAFVIPDTIFQLLVIGSLSAAFIPTFSKYLAKDEKEAWTMTSTTMNLIILIFMLLSA 110
Cdd:cd13124 250 TVPRRLQAAGLSESEATALYGILTGRAQPLVQLPTVIATALSTSLVPAISEAYAKGDKKELRRRINQALRLTLLIGLPAA 329
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 111 L-IFVFAYPLSRLIapgftaFQIGTMVQLLRIMLVAQIFFSISGFLTGIIQSHQRFLIPALAPVAYNLGIIAGIVFLSPT 189
Cdd:cd13124 330 VgLAVLAEPINTLL------FGDSEGGLILQILAPSILFLSLQQVTAAILQGLGKVKIPVINLLIGLLVKIVLNYVLIPI 403
|
170 180
....*....|....*....|..
gi 818798794 190 LGILGPAWGVVLGAVLHMLIQL 211
Cdd:cd13124 404 FGIYGAAIATVIGFLVAALLNL 425
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
35-211 |
1.40e-05 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 47.25 E-value: 1.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 35 RLLISSFFSAQSqlLDVYYAAFVIPDTIfqLLVIGSLSAAFIPTFSKYLA-KDEKEAWTMTSTTMNLIILIFMLLSALIF 113
Cdd:COG2244 197 RLLLGALLGPAA--VGIYSAAYRLASLL--LLLITALSQVLFPRLSRLLAeGDREELRRLYRKALRLLLLLGLPLALGLA 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 114 VFAYPLSRLIAPGftafQIGTMVQLLRIMLVAQIFFSISGFLTGIIQSHQRFLIPALAPVAYNLGIIAGIVFLSPTLGIL 193
Cdd:COG2244 273 LLAPPLLSLLFGP----EYAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAVLNLVLNLLLIPRYGLV 348
|
170
....*....|....*...
gi 818798794 194 GPAWGVVLGAVLHMLIQL 211
Cdd:COG2244 349 GAAIATLLSYLVLLLLLL 366
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
70-443 |
2.64e-05 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 46.69 E-value: 2.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 70 SLSAAFIPTF-SKYLAK-----DEKEAWTMTSTTMNLIILIFMLLSALIFVFAYPLSRLIapgftaFQIGTMVQLLRIML 143
Cdd:cd13124 45 TLATAGIPVAiSKLVAEynalgDYKGARRIFRVSLILLLILGLVFFLLLFFGAPFLAQLL------LGDPRLAPVIRALA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 144 VAQIFFSISGFLTGIIQSHQRFLIPALAPVAYNLGIIAGIVFL---------SPTLGILGPAWGVVLGAVLHMLIQLPLA 214
Cdd:cd13124 119 PAILIVPLLSVLRGYFQGLQNMTPTAVSQVIEQIVRVIVILVLaylllpvggGLYYAAAGATFGAVIGALAGLLVLLYYY 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 215 WRLGFRPSLSLNFSHPGVREVGRLMPpRVLALGI--------DQIEQFV-AVTLASLLVPGSLSLLNAARL--------- 276
Cdd:cd13124 199 RKKRRELKRLLRKSPRSKISTKEILK-ELLSYAIpitlssliLPLLQLIdSFTVPRRLQAAGLSESEATALygiltgraq 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 277 -LFTIPTSlFGVTISQAAFPQLAKEAAHSNLDQFRSTLISSFLQIAFMALPLSTLFIILRIPIVRLIFGAKTfpwaatll 355
Cdd:cd13124 278 pLVQLPTV-IATALSTSLVPAISEAYAKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDSE-------- 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 356 TGKTLAILCASAAFYAVMQLVIRGFYALHDTRTPLLVGFLAAIFSSLLAVFSVTWlgWGILGIAVAISATAILETLVLSW 435
Cdd:cd13124 349 GGLILQILAPSILFLSLQQVTAAILQGLGKVKIPVINLLIGLLVKIVLNYVLIPI--FGIYGAAIATVIGFLVAALLNLR 426
|
....*...
gi 818798794 436 LLYRRVSV 443
Cdd:cd13124 427 ALKKLLGF 434
|
|
| Polysacc_synt_3 |
pfam13440 |
Polysaccharide biosynthesis protein; |
106-346 |
1.06e-04 |
|
Polysaccharide biosynthesis protein;
Pssm-ID: 404342 [Multi-domain] Cd Length: 293 Bit Score: 44.51 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 106 MLLSALIFVFAYPLSRLIAPGFTAFQIGTMVQLLRIMLVAQIFFSISgflTGIIQSHQRFLIPALAP-VAYNLGIIAGIV 184
Cdd:pfam13440 55 LIFGALIYLILFALAPLIASFYNQPELVPVLRVLALVLILNGLSSVQ---TALLRRDLRFKKLFKITlTSSVIGGIVGIV 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 185 FLSPTLGILGPAWGVVLGAVLHMLIqlpLAWRLGFRPSLSLNFSH--PGVREVGRLMPPRVLALGIDQIEQFVavtLASL 262
Cdd:pfam13440 132 LAYLGFGVWALVIGTLAQQLLSLVL---LWLASDWRPRLTFSLKVikELFSFGSWLLLSNLLNYLARNLDNLI---IGKV 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 263 LVPGSLSLLNAARLLFTIPTSLFGVTISQAAFPQLAKeaAHSNLDQFRSTLISSFLQIAFMALPLSTLFIILRIPIVRLI 342
Cdd:pfam13440 206 LGTAALGLYSVAYRLALLPTANITSVITKVLFPALSR--IQDDKAKLRELYLRVLRLIAFIVFPIMAGLAVVAEPLVLVL 283
|
....
gi 818798794 343 FGAK 346
Cdd:pfam13440 284 LGSQ 287
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
84-424 |
1.44e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 44.42 E-value: 1.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 84 AKDEKEAWTMTSTTMNLIILIFMLLSALIFVFAYPLSRLIapGFTAFQIGTMVQLLRIMLVAQIFFSISGFLTGIIQSHQ 163
Cdd:cd13134 72 AKDKKKARQIAGVALLFNLLLGLVFSLLLLFFGAELLRLM--GLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHG 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 164 RFLIPALAPVAYNLGIIAGIVFL------SPTLGILGPAWGVVLGAVLHMLIQLPLAWR---LGFRPSLSLNFSHPGVRE 234
Cdd:cd13134 150 RTKIPMYVSLIMNILNIVGNYLLifgwfgLPKLGVAGVAISTVISRAVGLVLLFILLFRklkIRFRLKDLRPFPKKLLKK 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 235 VGRLMPPRVLALGIDQIEQFVAVTLASLLvpGSLSLlnAARLLFTIPTS---LFGVTISQAAFPQLAKEAAHSNLDQFRS 311
Cdd:cd13134 230 ILKIGLPSAGEELSYNLSQTVITAFIARL--GTAAL--AARTYASNISMfvfLFSLAIGQATQIIVGHLVGAGDFDEAYK 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 312 TLISSFLQIAFMALPLSTLFIILRIPIVRlIFGAKtfpwAATLLTGKTLAILCASAAFYAVMQLV-IRGFYALHDTRTPL 390
Cdd:cd13134 306 RVLKSLKIGLLVSLAVALLLALFREPILG-LFTDD----PEIIALGKTLLLISILLEPGRAFNIVlIGSLRAAGDARFPV 380
|
330 340 350
....*....|....*....|....*....|....*
gi 818798794 391 LVGFLAA-IFSSLLAVFSVTWLGWGILGIAVAISA 424
Cdd:cd13134 381 LIGIISMwGISVPLAYLLGIVLGLGLLGVWIAFAA 415
|
|
| MATE_like_11 |
cd13126 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
253-441 |
2.19e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides, such as O-antigen. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240531 [Multi-domain] Cd Length: 396 Bit Score: 43.83 E-value: 2.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 253 QFVAVTLASLLVPGSLSLLNAARLLfTIPTSLFGVTISQAAFPQLAKEAAHSNLDQFRSTLISSFLQIAfMALPLSTLFI 332
Cdd:cd13126 216 QNSDLLLGALGSLAAVGALRGAQTL-LGPLTILAAGLVTAAVPELARRKDMSPRRRRRAALVLSGVVAA-AALVWGLALL 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 333 ILRIPIVRLIFGAKTFPWAATLLtgktlaILCASAAFYAVMQLVIRGFYALHDTRTPLLVgflAAIFSSLLAVFSVTWLG 412
Cdd:cd13126 294 LLPDLIGEALLGDVWAGAQALLL------PLILAQAGAALAVGPAAYLLALGRAKGTLRV---NLVGAPQLLGLGLTGAL 364
|
170 180 190
....*....|....*....|....*....|
gi 818798794 413 -WGILGIAVAIsATAILETLVLSWLLYRRV 441
Cdd:cd13126 365 lGGAVGAAWGL-ALALLLGLPVWWLLLRRA 393
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
305-440 |
5.23e-04 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 42.50 E-value: 5.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 305 NLDQFRSTLISSFLQIAFMALPLSTLFIILRIPIVRLIFGAKtfpwAATLLTGKTLAILCASAAFYAVMQLVIRGFYALH 384
Cdd:cd13137 72 DYERARRALGQSLLLALLLSLPLALLGLLFAEPLLRLLGADP----EVIALALTYLRIVLLGIPFFFLSLVGNAALRGAG 147
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 385 DTRTPLLVGFLAAIFSSLLAVF----SVTWLGWGILGIAVAISATAILETLVLSWLLYRR 440
Cdd:cd13137 148 DTKTPMYIMIIVNVLNIVLDYVlifgLWGFPGLGVAGAALATVISRVVGALLLLFLLLRG 207
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
310-452 |
2.57e-03 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 40.24 E-value: 2.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 310 RSTLISSFLQIAFMALPLSTLFIILRIPIVRLIFGAKTFPWAATLLTGKTLAILCASAAFyAVMQLVIRG-FYALHDTRT 388
Cdd:cd13136 76 REEAIALLVRALLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQYLRIRILGAPA-VLLNYVATGwFRGLQDTRT 154
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 818798794 389 PLLVGFLAAIFSSLLAVFSVTWLGWGILGIAVAISATAILETLVLSWLLYRRVSVAPHKVFVPL 452
Cdd:cd13136 155 PLILQIVGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRRRVRLLGKSLSRRL 218
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
305-440 |
2.71e-03 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 40.13 E-value: 2.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 305 NLDQFRSTLISSFLQIAFMALPLSTLFIILRIPIVRLiFGAKtfpwAATLLTGKT-LAILCASAAFYAVMQLVIRGFYAL 383
Cdd:COG0534 79 DREEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRL-LGAD----PEVLALARDyLRIILLGLPFLLLFNVLNGILRGL 153
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 818798794 384 HDTRTPLLVGFLAAIFSSLLAVFSVTWLGWGILGIAVAISATAILETLVLSWLLYRR 440
Cdd:COG0534 154 GDTKTPMIIMLIGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRK 210
|
|
| MATE_tuaB_like |
cd13127 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
36-225 |
4.95e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240532 [Multi-domain] Cd Length: 406 Bit Score: 39.39 E-value: 4.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 36 LLISSFFSAQSqlLDVYYAAFVIPDTIFQLLvIGSLSAAFIPTFSKyLAKDEKEAWTMTSTTMNLIILIFMLLSALIFVF 115
Cdd:cd13127 224 LIIGKFLGAAA--LGYYSRAYRLALLPVQNI-TGPITRVLFPALSR-LQDDPERLRRAYLKALRLLALITFPLMVGLALL 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 116 AYPLSRLIapgFTAfQIGTMVQLLRIMLVAQIFFSISGFLTGIIQSHQRFLIPALAPVAYNLGIIAGIVFLSPtLGILGP 195
Cdd:cd13127 300 AEPLVLLL---LGE-KWLPAVPILQILALAGLFQPLSSLNGSLLLALGRTDLLLKLGLIKAVLTVLALLIGIP-YGIIGV 374
|
170 180 190
....*....|....*....|....*....|
gi 818798794 196 AWGVVLGAVLHMLIQLPLAWRLGFRPSLSL 225
Cdd:cd13127 375 AIAYVIASLLSFPLNLYLAGRLIGISLLEL 404
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
54-440 |
6.68e-03 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 39.03 E-value: 6.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 54 AAFVIPDTIFQLL--VIGSLSAAFIPTFSKYL-AKDEKEAWTMTSTTMNLIILIFMLLSALIFVFAYPLSRLIAPGFTAF 130
Cdd:cd13137 37 AAVGLATQVLWLLlvLNMALGTGTVALVSQSYgAGDYERARRALGQSLLLALLLSLPLALLGLLFAEPLLRLLGADPEVI 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 131 QIGTmvQLLRIMLVAQIFFSISGFLTGIIQSHQRFLIPALAPVAYNLGIIAGIVFL------SPTLGILGPAWGVVLGAV 204
Cdd:cd13137 117 ALAL--TYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVNVLNIVLDYVLifglwgFPGLGVAGAALATVISRV 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 205 LHMLIQLPLAWRLGFRPSLSLNFSHP---GVREVGRLMPPRVLALGIDQIEQFVAVTLASLLVPGSLSLLNAARLLFTIP 281
Cdd:cd13137 195 VGALLLLFLLLRGRLPIKISFKGFRLdrkIIKKLLRIGLPAGLEQLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLA 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 282 TsLFGVTISQAAFPQLAKEAAHSNLDQ-FRSTLISSFLQIAFMALpLSTLFIILRIPIVRLIFG-AKTFPWAATLLtgkt 359
Cdd:cd13137 275 F-MPGFGFSMAASTLVGQNLGAGDPDEaRRYGKRALRLGVLFMGL-LGLLLFIFAPPLASLFTPdPEVIELGVLYL---- 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798794 360 lAILCASAAFYAVMQLVIRGFYALHDTRTPLLVGFLAAIFSSL-LAVFSVTWLGWGILGIAVAISATAILETLVLSWLLY 438
Cdd:cd13137 349 -RIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLpLAYLLGFVLGLGLTGIWLAMFVDTIVRAILLLYRFR 427
|
..
gi 818798794 439 RR 440
Cdd:cd13137 428 KG 429
|
|
| |
