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Conserved domains on  [gi|818798789|gb|KKU38774|]
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Protein GrpE [Candidatus Amesbacteria bacterium GW2011_GWA1_46_35]

Protein Classification

nucleotide exchange factor GrpE( domain architecture ID 10001738)

nucleotide exchange factor GrpE functions as a nucleotide exchange factor for DnaK and participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may also function as a thermosensor

CATH:  3.90.20.20|2.30.22.10
Gene Ontology:  GO:0000774|GO:0051087|GO:0042803|GO:0006457
SCOP:  4003783|4002724

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 38-164 2.10e-36

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 122.95  E-value: 2.10e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  38 VKTLTENWKRALADYHNLVKRVDADKKDFVTYATANIMAKLLPTLDVLELAAIHSQD--------QGVQMAVKQFRDVLT 109
Cdd:COG0576    8 LAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAEEdedvksllEGVEMTLKQLLDVLE 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 818798789 110 AEGLQEISPKiGDSYNHEIHECLETLPGE--PDNTIAEIVTKGYKINNYVIRPAKIK 164
Cdd:COG0576   88 KHGVEEIEPV-GEPFDPNLHEAVSQVPSPdvEPGTVVEVLQKGYRLGDRVLRPAMVV 143
 
Name Accession Description Interval E-value
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 38-164 2.10e-36

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 122.95  E-value: 2.10e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  38 VKTLTENWKRALADYHNLVKRVDADKKDFVTYATANIMAKLLPTLDVLELAAIHSQD--------QGVQMAVKQFRDVLT 109
Cdd:COG0576    8 LAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAEEdedvksllEGVEMTLKQLLDVLE 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 818798789 110 AEGLQEISPKiGDSYNHEIHECLETLPGE--PDNTIAEIVTKGYKINNYVIRPAKIK 164
Cdd:COG0576   88 KHGVEEIEPV-GEPFDPNLHEAVSQVPSPdvEPGTVVEVLQKGYRLGDRVLRPAMVV 143
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 39-164 3.98e-33

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 114.53  E-value: 3.98e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  39 KTLTENWKRALADYHNLVKRVDADKKDFVTYATANIMAKLLPTLDVLELAAIHSQD--------QGVQMAVKQFRDVLTA 110
Cdd:cd00446    1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKeeelknllEGVEMTLKQLLKVLEK 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 818798789 111 EGLQEISPKiGDSYNHEIHECLETLPGE--PDNTIAEIVTKGYKINNYVIRPAKIK 164
Cdd:cd00446   81 HGVEEIEPE-GEKFDPNLHEAVMQVESPdkEPGTVVEVLQKGYKLHDRVLRPAMVV 135
GrpE pfam01025
GrpE;
38-164 3.80e-28

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 102.69  E-value: 3.80e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789   38 VKTLTENWKRALADYHNLVKRVDADKKDFVTYATANIMAKLLPTLDVLELAAIHSQD--------QGVQMAVKQFRDVLT 109
Cdd:pfam01025  27 IEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSAPEnedvksllEGVEMTLKQLLKILE 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 818798789  110 AEGLQEISPKiGDSYNHEIHECLETLPGE--PDNTIAEIVTKGYKINNYVIRPAKIK 164
Cdd:pfam01025 107 KHGVEKIEPE-GEPFDPNLHEAVSQVPSPekPEGTVVEVLQKGYKLHDRVLRPAMVV 162
PRK14144 PRK14144
heat shock protein GrpE; Provisional
 43-163 1.02e-19

heat shock protein GrpE; Provisional


Pssm-ID: 184535 [Multi-domain]  Cd Length: 199  Bit Score: 81.69  E-value: 1.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  43 ENWK---RALADYHNLVKRVDADKKDFVTYATANIMAKLLPTLDVLELA---AIHSQD----QGVQMAVKQFRDVLTAEG 112
Cdd:PRK14144  63 ENWEksvRALAELENVRRRMEREVANAHKYGVEKLISALLPVVDSLEQAlqlADKNSDpsmhEGLELTMKLFLDALQKFD 142

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 818798789 113 LQEISPkIGDSYNHEIHECL--ETLPGEPDNTIAEIVTKGYKINNYVIRPAKI 163
Cdd:PRK14144 143 VEQIDP-LGQTFDPQQHEAMsmQPAPGAPPNSVITVFQKGYKLSDRVIRPARV 194
 
Name Accession Description Interval E-value
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 38-164 2.10e-36

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 122.95  E-value: 2.10e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  38 VKTLTENWKRALADYHNLVKRVDADKKDFVTYATANIMAKLLPTLDVLELAAIHSQD--------QGVQMAVKQFRDVLT 109
Cdd:COG0576    8 LAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAEEdedvksllEGVEMTLKQLLDVLE 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 818798789 110 AEGLQEISPKiGDSYNHEIHECLETLPGE--PDNTIAEIVTKGYKINNYVIRPAKIK 164
Cdd:COG0576   88 KHGVEEIEPV-GEPFDPNLHEAVSQVPSPdvEPGTVVEVLQKGYRLGDRVLRPAMVV 143
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 39-164 3.98e-33

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 114.53  E-value: 3.98e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  39 KTLTENWKRALADYHNLVKRVDADKKDFVTYATANIMAKLLPTLDVLELAAIHSQD--------QGVQMAVKQFRDVLTA 110
Cdd:cd00446    1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKeeelknllEGVEMTLKQLLKVLEK 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 818798789 111 EGLQEISPKiGDSYNHEIHECLETLPGE--PDNTIAEIVTKGYKINNYVIRPAKIK 164
Cdd:cd00446   81 HGVEEIEPE-GEKFDPNLHEAVMQVESPdkEPGTVVEVLQKGYKLHDRVLRPAMVV 135
GrpE pfam01025
GrpE;
38-164 3.80e-28

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 102.69  E-value: 3.80e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789   38 VKTLTENWKRALADYHNLVKRVDADKKDFVTYATANIMAKLLPTLDVLELAAIHSQD--------QGVQMAVKQFRDVLT 109
Cdd:pfam01025  27 IEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSAPEnedvksllEGVEMTLKQLLKILE 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 818798789  110 AEGLQEISPKiGDSYNHEIHECLETLPGE--PDNTIAEIVTKGYKINNYVIRPAKIK 164
Cdd:pfam01025 107 KHGVEKIEPE-GEPFDPNLHEAVSQVPSPekPEGTVVEVLQKGYKLHDRVLRPAMVV 162
PRK14144 PRK14144
heat shock protein GrpE; Provisional
 43-163 1.02e-19

heat shock protein GrpE; Provisional


Pssm-ID: 184535 [Multi-domain]  Cd Length: 199  Bit Score: 81.69  E-value: 1.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  43 ENWK---RALADYHNLVKRVDADKKDFVTYATANIMAKLLPTLDVLELA---AIHSQD----QGVQMAVKQFRDVLTAEG 112
Cdd:PRK14144  63 ENWEksvRALAELENVRRRMEREVANAHKYGVEKLISALLPVVDSLEQAlqlADKNSDpsmhEGLELTMKLFLDALQKFD 142

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 818798789 113 LQEISPkIGDSYNHEIHECL--ETLPGEPDNTIAEIVTKGYKINNYVIRPAKI 163
Cdd:PRK14144 143 VEQIDP-LGQTFDPQQHEAMsmQPAPGAPPNSVITVFQKGYKLSDRVIRPARV 194
PRK14140 PRK14140
heat shock protein GrpE; Provisional
 47-164 3.76e-16

heat shock protein GrpE; Provisional


Pssm-ID: 237622 [Multi-domain]  Cd Length: 191  Bit Score: 71.95  E-value: 3.76e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  47 RALADYHNLVKRVDADKKDFVTYATANIMAKLLPTLDVLELA-AIHSQD-------QGVQMAVKQFRDVLTAEGLQEIsP 118
Cdd:PRK14140  62 RLQADFENYKRRIQKENEAAEKYRAQSLASDLLPALDNFERAlQIEADDeqtksllKGVEMVHRQLLEALKKEGVEVI-E 140

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 818798789 119 KIGDSYNHEIHECLETLPgEPD---NTIAEIVTKGYKINNYVIRPAKIK 164
Cdd:PRK14140 141 AVGEQFDPNLHQAVMQDE-DEDfesNEVVEELQKGYKLKDRVIRPSMVK 188
PRK14148 PRK14148
heat shock protein GrpE; Provisional
 36-163 3.86e-16

heat shock protein GrpE; Provisional


Pssm-ID: 172637 [Multi-domain]  Cd Length: 195  Bit Score: 72.09  E-value: 3.86e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  36 DTVKTLTENWK-------RALADYHNLVKRVDADKKDFVTYATANIMAKLLPTLDVLELAAIH--------SQDQGVQMA 100
Cdd:PRK14148  47 DTIKELEDSCDqfkdealRAKAEMENIRKRAERDVSNARKFGIEKFAKELLPVIDSIEQALKHevkleeaiAMKEGIELT 126

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 818798789 101 VKQFRDVLTAEGLQEISPKiGDSYNHEIHECLETLPGEP--DNTIAEIVTKGYKINNYVIRPAKI 163
Cdd:PRK14148 127 AKMLVDILKKNGVEELDPK-GEKFDPNLHEAMAMIPNPEfeDNTIFDVFQKGYMLNGRIVRAAKV 190
PRK14153 PRK14153
heat shock protein GrpE; Provisional
 41-161 5.86e-16

heat shock protein GrpE; Provisional


Pssm-ID: 184540 [Multi-domain]  Cd Length: 194  Bit Score: 71.80  E-value: 5.86e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  41 LTENWKRALADYHNLVKRVDADKKDFVTYATANIMAKLLPTLDVLELA---AIHSQD-----QGVQMAVKQFRDVLTAEG 112
Cdd:PRK14153  52 LKEQLFRLAAEFDNFRKRTAREMEENRKFVLEQVLLDLLEVTDNFERAlesARTAEDmnsivEGIEMVSKQFFSILEKYG 131

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 818798789 113 LQEISPKIG--DSYNHEIHECLETlPGEPDNTIAEIVTKGYKINNYVIRPA 161
Cdd:PRK14153 132 LERIECEGEefDPHRHEAMMHVET-SEVPDNTIVDVCKPGYALNSKVIRPA 181
PRK14164 PRK14164
heat shock protein GrpE; Provisional
 17-161 7.95e-16

heat shock protein GrpE; Provisional


Pssm-ID: 237632 [Multi-domain]  Cd Length: 218  Bit Score: 71.76  E-value: 7.95e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  17 ASDASPRLDLRGGGPQAEGDtVKTLTENWKRALADYHNLVKRVDADKKDFVTYATANIMAKLLPTLDVLELAAIHSQ-DQ 95
Cdd:PRK14164  66 LDDVDPELADDGEASTVEAQ-LAERTEDLQRVTAEYANYRRRTERERQAIIETAKAGVATDLLPILDDLDLAEQHGDlNE 144

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 818798789  96 GvqmAVKQFRDVLTA--EGLQ-EISPKIGDSYNHEIHECLETLPGEPDNTIAEIVTKGYKINNYVIRPA 161
Cdd:PRK14164 145 G---PLKAFSDKLTNvlAGLKvEKFGEEGDAFDPEIHEAVQDLSSGDEKVLGTVLRKGYRMGDRVLRTA 210
PRK14163 PRK14163
heat shock protein GrpE; Provisional
 3-163 1.11e-15

heat shock protein GrpE; Provisional


Pssm-ID: 184546 [Multi-domain]  Cd Length: 214  Bit Score: 71.31  E-value: 1.11e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789   3 TKKSPNITPHPPL----TASDASPRL-DLRGGGPQ----------AEGDTVKTL----TENWKRALADYHNLVKRVDADK 63
Cdd:PRK14163   2 TEETPGFEEKPDVpsgaTPDDAEPKAaSEEGAAPAgdaaatagltAQLDQVRTAlgerTADLQRLQAEYQNYRRRVERDR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  64 KDFVTYATANIMAKLLPTLDVLELAAIHSQDQGVQMAVKQFRDVLTAE-GLQEISpKIGDSYNHEIHECL--ETLPGEPD 140
Cdd:PRK14163  82 VTVKEIAVANLLSELLPVLDDVGRAREHGELVGGFKSVAESLETTVAKlGLQQFG-KEGEPFDPTIHEALmhSYAPDVTE 160

                        170       180
                 ....*....|....*....|...
gi 818798789 141 NTIAEIVTKGYKINNYVIRPAKI 163
Cdd:PRK14163 161 TTCVAILQPGYRIGERTIRPARV 183
PRK14154 PRK14154
heat shock protein GrpE; Provisional
 47-163 4.15e-15

heat shock protein GrpE; Provisional


Pssm-ID: 237626 [Multi-domain]  Cd Length: 208  Bit Score: 69.84  E-value: 4.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  47 RALADYHNLVKRVDADKKDFVTYATANIMAKLLPTLDVL---------ELAAIHSQDQGVQMAVKQFRDVLTAEGLQEIS 117
Cdd:PRK14154  77 RAQAEMDNLRKRIEREKADIIKFGSKQLITDLLPVADSLihglespasEDPQVKSMRDGMSLTLDLLHNTLAKHGVQVIN 156

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 818798789 118 PKIGDSYNHEIHECL--ETLPGEPDNTIAEIVTKGYKINNYVIRPAKI 163
Cdd:PRK14154 157 PNPGDPFDPALHEAMsvQAVPDAKPDTIIQVLQKGYQLNGRVLRAARV 204
PRK14149 PRK14149
heat shock protein GrpE; Provisional
 39-170 8.95e-15

heat shock protein GrpE; Provisional


Pssm-ID: 184538 [Multi-domain]  Cd Length: 191  Bit Score: 68.36  E-value: 8.95e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  39 KTLTENWKRALADYHNLVKRVDADKKDFVTYATANIMAKLLPTLDVLELAAIHSQD--------QGVQMAVKQFRDVLTA 110
Cdd:PRK14149  53 KEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGALKSAAEvdkesaltKGLELTMEKLHEVLAR 132

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 818798789 111 EGLQEIsPKIGDsYNHEIHECLETLPGEP--DNTIAEIVTKGYKINNYVIRPAKIkAYVKDN 170
Cdd:PRK14149 133 HGIEGI-ECLEE-FDPNFHNAIMQVKSEEkeNGKIVQVLQQGYKYKGRVLRPAMV-SIAKND 191
PRK14145 PRK14145
heat shock protein GrpE; Provisional
 46-164 2.10e-14

heat shock protein GrpE; Provisional


Pssm-ID: 184536 [Multi-domain]  Cd Length: 196  Bit Score: 67.64  E-value: 2.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  46 KRALADYHNLVKRVDADKKDFVTYATANIMAKLLPTLDVLELAAIHSQD-----QGVQMAVKQFRDVLTAEGLQEISP-- 118
Cdd:PRK14145  69 QRLKAEFENYRKRTEKEKSEMVEYGKEQVILELLPVMDNFERALASSGDynslkEGIELIYRQFKKILDKFGVKEIEAeg 148

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 818798789 119 KIGDSYNHeiHECL-ETLPGEPDNTIAEIVTKGYKINNYVIRPAKIK 164
Cdd:PRK14145 149 QIFDPYKH--HAVMqEEVEGKQPNEIIEVFQKGYYLKDKVIRPSLVK 193
PRK14160 PRK14160
heat shock protein GrpE; Provisional
 38-164 1.13e-13

heat shock protein GrpE; Provisional


Pssm-ID: 237629 [Multi-domain]  Cd Length: 211  Bit Score: 65.93  E-value: 1.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  38 VKTLTENWKRALADYHNLVKRVDADKKDFVTYATANIMAKLLPTLDVLELAA-----IHSQDQGVQMAVKQFRDVLTAEG 112
Cdd:PRK14160  77 LEALKDRLLRTVAEYDNYRKRTAKEKEGIYSDACEDVLKELLPVLDNLERAAavegsVEDLKKGIEMTVKQFKTSLEKLG 156

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 818798789 113 LQEISPKIGdsYNHEIHECLETLPGEP--DNTIAEIVTKGYKINNYVIRPAKIK 164
Cdd:PRK14160 157 VEEISTEGE--FDPNLHNAVMHVEDENygENEIVEVFQKGYKRGDKVIRYSMVK 208
PRK14139 PRK14139
heat shock protein GrpE; Provisional
 10-161 1.93e-13

heat shock protein GrpE; Provisional


Pssm-ID: 237621 [Multi-domain]  Cd Length: 185  Bit Score: 64.61  E-value: 1.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  10 TPHPPLTASDASPRLDLRGGGPQAegdTVKTLTENWKRALADYHNLVKRVDADKKDFVTYATANIMAKLLPTLDVLELA- 88
Cdd:PRK14139  23 AAAAAAAAEDAAPALEAELAEAEA---KAAELQDSFLRAKAETENVRRRAQEDVAKAHKFAIESFAESLLPVKDSLEAAl 99

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 818798789  89 AIHSQD-----QGVQMAVKQFRDVLTAEGLQEISPkIGDSYNHEIHECLETLPGE-PDNTIAEIVTKGYKINNYVIRPA 161
Cdd:PRK14139 100 ADESGDleklrEGVELTLKQLTSAFEKGRVVEINP-VGEKFDPHQHQAISMVPAEqEPNTVVAVLQKGYTIADRVLRPA 177
PRK14156 PRK14156
heat shock protein GrpE; Provisional
 47-166 8.55e-13

heat shock protein GrpE; Provisional


Pssm-ID: 237628 [Multi-domain]  Cd Length: 177  Bit Score: 62.93  E-value: 8.55e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  47 RALADYHNLVKRVDADKKDFVTYATANIMAKLLPTLDVLE--LAAIHSQD---QGVQMAVKQFRDVLTAEGLQEISpkiG 121
Cdd:PRK14156  52 RAHAEMQNIQRRANEERQQLQRYRSQDLAKAILPSLDNLEraLAVEGLTDdvkKGLEMVQESLIQALKEEGVEEVA---V 128

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 818798789 122 DSYNHEIHECLETLPGE---PDNTIAEIVTKGYKINNYVIRPAKIKAY 166
Cdd:PRK14156 129 DSFDHNLHMAVQTLPADdehPADSIAQVFQKGYKLHERLLRPAMVVVY 176
PRK14158 PRK14158
heat shock protein GrpE; Provisional
 30-161 2.17e-12

heat shock protein GrpE; Provisional


Pssm-ID: 172646 [Multi-domain]  Cd Length: 194  Bit Score: 62.26  E-value: 2.17e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  30 GPQAEGDTVKTLTE-----------NWKRAL---ADYHNLVKRVDADKKDFVTYATANIMAKLLPTLDVLELAAIHSQD- 94
Cdd:PRK14158  34 QPVAAADRIKELEEalaakeaeaaaNWDKYLrerADLENYRKRVQKEKEELLKYGNESLILEILPAVDNMERALDHADEe 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 818798789  95 ------QGVQMAVKQFRDVLTAEGLQEISPKIGDSYNHEIHECL---ETLPGEPdNTIAEIVTKGYKINNYVIRPA 161
Cdd:PRK14158 114 smsaiiEGIRMTLSMLLSTLKKFGVTPVEAEKGTPFDPAYHQAMcqvESAEQEP-NTVVAVFQKGYLLNERLLRPA 188
PRK14159 PRK14159
heat shock protein GrpE; Provisional
 32-163 7.25e-12

heat shock protein GrpE; Provisional


Pssm-ID: 172647 [Multi-domain]  Cd Length: 176  Bit Score: 60.47  E-value: 7.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  32 QAEGDTVKtltENWKRALADYHNLVKRVDADKKDFVTYATANIMAKLLPTLDVLELAA-IHSQDQ-------GVQMAVKQ 103
Cdd:PRK14159  36 QKDYDELK---DKYMRANAEFENIKKRMEKEKLSAMAYANESFAKDLLDVLDALEAAVnVECHDEislkikeGVQNTLDL 112

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 818798789 104 FRDVLTAEGLQEIspKIGDSYNHEIHECLETLPGE--PDNTIAEIVTKGYKINNYVIRPAKI 163
Cdd:PRK14159 113 FLKKLEKHGVALI--KEEKEFDPNLHEAMFHVDSEnhQSGEVVQVLQKGYKIADRVIRPTKV 172
PRK14143 PRK14143
heat shock protein GrpE; Provisional
 7-164 3.18e-11

heat shock protein GrpE; Provisional


Pssm-ID: 237624 [Multi-domain]  Cd Length: 238  Bit Score: 59.74  E-value: 3.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789   7 PNITPHPPLTASDASPRLDLRGGGPQAEGDTVK----TLTENWKRALADYHNLVKRVDADKKDFVTYATANIMAKLLPTL 82
Cdd:PRK14143  48 AESSPDSGSAASETAADNAARLAQLEQELESLKqeleELNSQYMRIAADFDNFRKRTSREQEDLRLQLKCNTLSEILPVV 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  83 DVLELA------------AIHSQDQGVqmaVKQFRDVLTAEGLQEISPkIGDSYNHEIHECL--ETLPGEPDNTIAEIVT 148
Cdd:PRK14143 128 DNFERArqqlkpegeeaqALHRSYQGL---YKQLVDVLKRLGVSPMRV-VGQEFDPNLHEAVlrEPSDEHPEDVVLEELQ 203

                        170
                 ....*....|....*.
gi 818798789 149 KGYKINNYVIRPAKIK 164
Cdd:PRK14143 204 RGYHLGGRVLRHAMVK 219
PRK14151 PRK14151
heat shock protein GrpE; Provisional
 47-161 7.37e-11

heat shock protein GrpE; Provisional


Pssm-ID: 172640 [Multi-domain]  Cd Length: 176  Bit Score: 57.87  E-value: 7.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  47 RALADYHNLVKRVDADKKDFVTYATANIMAKLLPTLDVLELA---------AIHSQDQGVQMAVKQFRDVLTAEGLQEIS 117
Cdd:PRK14151  45 RAAADLQNVRRRAEQDVEKAHKFALEKFAGDLLPVVDSLERGlelssaddeAIKPMREGVELTLKMFQDTLKRYQLEAVD 124

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 818798789 118 PKiGDSYNHEIHECL---ETLPGEPdNTIAEIVTKGYKINNYVIRPA 161
Cdd:PRK14151 125 PH-GEPFNPEHHQAMamqESADVEP-NSVLKVFQKGYLLNGRLLRPA 169
PRK14150 PRK14150
heat shock protein GrpE; Provisional
 78-161 6.52e-10

heat shock protein GrpE; Provisional


Pssm-ID: 184539 [Multi-domain]  Cd Length: 193  Bit Score: 55.31  E-value: 6.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  78 LLPTLDVLELA---------AIHSQDQGVQMAVKQFRDVLTAEGLQEISPkIGDSYNHEIHECLETLPGE--PDNTIAEI 146
Cdd:PRK14150  94 LLPVIDNLERAlqaadkeneALKALIEGVELTLKSLLDTVAKFGVEVVGP-VGEPFNPEVHQAISMQESEdhEPNTVMMV 172

                         90
                 ....*....|....*
gi 818798789 147 VTKGYKINNYVIRPA 161
Cdd:PRK14150 173 MQKGYTLNGRLLRPA 187
PRK14146 PRK14146
heat shock protein GrpE; Provisional
 38-164 4.84e-09

heat shock protein GrpE; Provisional


Pssm-ID: 172635 [Multi-domain]  Cd Length: 215  Bit Score: 53.58  E-value: 4.84e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  38 VKTLTENWKRALADYHNLVKRvdaDKKDFVTY---ATANIMAKLLPTLDVLE-LAAIHSQD-------QGVQMAVKQFRD 106
Cdd:PRK14146  70 IESLKDSWARERAEFQNFKRR---SAQEFVSIrkeAVKSLVSGFLNPIDNLErVGATQNQSeelkpfvEGVKMILKEFYS 146

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 818798789 107 VLTAEGLQEISPKiGDSYNHEIHECLETLPGE--PDNTIAEIVTKGYKI----NNYVIRPAKIK 164
Cdd:PRK14146 147 VLEKSNVIRFDPK-GEPFDPMSMEALSSEEGDqySEETVIDVYQAGYYYkeneDKFTLRPARVR 209
PRK14147 PRK14147
heat shock protein GrpE; Provisional
 6-161 7.01e-09

heat shock protein GrpE; Provisional


Pssm-ID: 237625 [Multi-domain]  Cd Length: 172  Bit Score: 52.26  E-value: 7.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789   6 SPNITPHPPLTASDASPRLDLRGGGPQAEGDTVktltenwkRALADYHNLVKRVDADKKDFVTYATANIMAKLLPTLDVL 85
Cdd:PRK14147  10 SEDLAQNPPETDPLKAEVESLRSEIALVKADAL--------RERADLENQRKRIARDVEQARKFANEKLLGELLPVFDSL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  86 ELAAIHSQDQ------GVQMAVKQFRDVLTAEGLQEISPkIGDSYNHEIHECLET--LPGEPDNTIAEIVTKGYKINNYV 157
Cdd:PRK14147  82 DAGLTAAGTEpsplrdGLELTYKQLLKVAADNGLTLLDP-VGQPFNPEHHQAISQgeAEGVAPGHVVQVFQKGYLLNERL 160


                 ....
gi 818798789 158 IRPA 161
Cdd:PRK14147 161 LRPA 164
PRK14161 PRK14161
heat shock protein GrpE; Provisional
 38-168 7.56e-09

heat shock protein GrpE; Provisional


Pssm-ID: 237630 [Multi-domain]  Cd Length: 178  Bit Score: 52.28  E-value: 7.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  38 VKTLTENWKRALADYHNLVKRVDADKKDFVTYATANIMAKLLPTLDVLELAAIHSQDQ----------GVQMAVKQFRDV 107
Cdd:PRK14161  35 IEELKDKLIRTTAEIDNTRKRLEKARDEAKDYAIATFAKELLNVSDNLSRALAHKPANsdvevtniiaGVQMTKDELDKV 114

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 818798789 108 LTAEGLQEISPKIGDSYNHEIHECLETL--PGEPDNTIAEIVTKGYKINNYVIRPAKIKAYVK 168
Cdd:PRK14161 115 FHKHHIEEIKPEIGSMFDYNLHNAISQIehPDHAPNSIITLMQSGYKIRDRLLRPATVQVVKK 177
PRK14162 PRK14162
heat shock protein GrpE; Provisional
 39-161 5.14e-08

heat shock protein GrpE; Provisional


Pssm-ID: 237631 [Multi-domain]  Cd Length: 194  Bit Score: 50.22  E-value: 5.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  39 KTLTENWKRALADYHNLVKRVDADKKDFVTYATANIMAKLLPTLDVLELA-AIHSQDQ-------GVQMAVKQFRDVLTA 110
Cdd:PRK14162  56 KDLEDKYLRSQAEIQNMQNRYAKERAQLIKYESQSLAKDVLPAMDNLERAlAVKADDEaakqlkkGVQMTLDHLVKALKD 135

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 818798789 111 EGLQEISPKiGDSYNHEIHECLETLPGEPD---NTIAEIVTKGYKINNYVIRPA 161
Cdd:PRK14162 136 HGVTEIKAD-GEKFDPTLHQAVQTVAAENDdqkDHVVQVLQKGYQYKDRTLRPA 188
PRK14155 PRK14155
heat shock protein GrpE; Provisional
 38-168 3.96e-07

heat shock protein GrpE; Provisional


Pssm-ID: 237627 [Multi-domain]  Cd Length: 208  Bit Score: 48.04  E-value: 3.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  38 VKTLTENWKRALADYHNLVKRVDADKKDFVTYATANIMAKLLPTLDVLELAAIHS----QDQ-------GVQMAVKQFRD 106
Cdd:PRK14155  29 VAALKDQALRYAAEAENTKRRAEREMNDARAYAIQKFARDLLGAADNLGRATAASpkdsADPavknfiiGVEMTEKELLG 108

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 818798789 107 VLTAEGLQEISPKIGDSYNHEIHECLETLPGE--PDNTIAEIVTKGYKINNYVIRPAKIKAYVK 168
Cdd:PRK14155 109 AFERNGLKKIDPAKGDKFDPHLHQAMMEQPSTevAAGGVLQVMQAGYELMGRLVRPAMVAVAAK 172
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 47-161 1.99e-06

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 45.82  E-value: 1.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818798789  47 RALADYHNLVKRVDADKKDFVTYATANIMAKLLPTLDVLELA-------AIHSQD-------QGVQMAVKQFRDVLTAEG 112
Cdd:PRK14141  56 RLAAEMENLRKRTQRDVADARAYGIAGFARDMLSVSDNLRRAldaipaeARAAADaglkaliEGVEMTERAMLNALERHG 135

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 818798789 113 LQEISPKiGDSYNHEIHECLETLPGE--PDNTIAEIVTKGYKINNYVIRPA 161
Cdd:PRK14141 136 VKKLDPE-GQKFDPNFHQAMFEVPNPdvPNNTVVQVVQAGYTIGERVLRPA 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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