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Conserved domains on  [gi|818770893|gb|KKU12170|]
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Acr family acridine efflux pump AcrA [Candidatus Woesebacteria bacterium GW2011_GWA1_45_8]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcrA super family cl34052
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ...
 29-86 2.42e-10

Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];


The actual alignment was detected with superfamily member COG0845:

Pssm-ID: 440606 [Multi-domain]  Cd Length: 324  Bit Score: 55.33  E-value: 2.42e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 818770893  29 PTYENVLAIPVSSITEDNK---VFIKTKRGYVE-RKIKTGLQNDTRAQVISGLSQNDEVVVE 86
Cdd:COG0845  244 GERENALLVPASAVVRDGGgayVFVVDADGKVErRPVTLGRRDGDQVEVLSGLKAGDRVVVS 305
 
Name Accession Description Interval E-value
AcrA COG0845
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ...
 29-86 2.42e-10

Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];


Pssm-ID: 440606 [Multi-domain]  Cd Length: 324  Bit Score: 55.33  E-value: 2.42e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 818770893  29 PTYENVLAIPVSSITEDNK---VFIKTKRGYVE-RKIKTGLQNDTRAQVISGLSQNDEVVVE 86
Cdd:COG0845  244 GERENALLVPASAVVRDGGgayVFVVDADGKVErRPVTLGRRDGDQVEVLSGLKAGDRVVVS 305
PRK11578 PRK11578
macrolide transporter subunit MacA; Provisional
 31-85 5.21e-06

macrolide transporter subunit MacA; Provisional


Pssm-ID: 183211 [Multi-domain]  Cd Length: 370  Bit Score: 43.22  E-value: 5.21e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 818770893  31 YENVLAIPVSSITE---DNKVFIKTKRGYVERK--IKTGLQNDTRAQVISGLSQNDEVVV 85
Cdd:PRK11578 303 VKNVLTIPLSALGDpvgDNRYKVKLLRNGETREreVTIGARNDTDVEIVKGLEAGDEVII 362
RND_mfp TIGR01730
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ...
 27-86 2.39e-05

RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273776 [Multi-domain]  Cd Length: 322  Bit Score: 41.15  E-value: 2.39e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 818770893   27 FSPTYENVLAIPVSSITEDNK---VFIKTKRGYVE-RKIKTGLQNDTRAQVISGLSQNDEVVVE 86
Cdd:TIGR01730 245 SLKVRSSAIVVPTQAVIEDLNgkyVYVVKNDGKVSkRPVEVGLRNGGYVEIESGLKAGDQIVTA 308
 
Name Accession Description Interval E-value
AcrA COG0845
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ...
 29-86 2.42e-10

Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];


Pssm-ID: 440606 [Multi-domain]  Cd Length: 324  Bit Score: 55.33  E-value: 2.42e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 818770893  29 PTYENVLAIPVSSITEDNK---VFIKTKRGYVE-RKIKTGLQNDTRAQVISGLSQNDEVVVE 86
Cdd:COG0845  244 GERENALLVPASAVVRDGGgayVFVVDADGKVErRPVTLGRRDGDQVEVLSGLKAGDRVVVS 305
PRK11578 PRK11578
macrolide transporter subunit MacA; Provisional
 31-85 5.21e-06

macrolide transporter subunit MacA; Provisional


Pssm-ID: 183211 [Multi-domain]  Cd Length: 370  Bit Score: 43.22  E-value: 5.21e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 818770893  31 YENVLAIPVSSITE---DNKVFIKTKRGYVERK--IKTGLQNDTRAQVISGLSQNDEVVV 85
Cdd:PRK11578 303 VKNVLTIPLSALGDpvgDNRYKVKLLRNGETREreVTIGARNDTDVEIVKGLEAGDEVII 362
RND_mfp TIGR01730
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ...
 27-86 2.39e-05

RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273776 [Multi-domain]  Cd Length: 322  Bit Score: 41.15  E-value: 2.39e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 818770893   27 FSPTYENVLAIPVSSITEDNK---VFIKTKRGYVE-RKIKTGLQNDTRAQVISGLSQNDEVVVE 86
Cdd:TIGR01730 245 SLKVRSSAIVVPTQAVIEDLNgkyVYVVKNDGKVSkRPVEVGLRNGGYVEIESGLKAGDQIVTA 308
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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