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Conserved domains on  [gi|818770764|gb|KKU12053|]
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hypothetical protein UX19_C0009G0008 [Candidatus Woesebacteria bacterium GW2011_GWA1_45_8]

Protein Classification

tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE( domain architecture ID 10002738)

tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB

Gene Symbol:  tsaE
Gene Ontology:  GO:0002949|GO:0005524
PubMed:  36362385

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TsaE COG0802
tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE [Translation, ribosomal ...
5-149 7.49e-49

tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE [Translation, ribosomal structure and biogenesis]; tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 440565  Cd Length: 146  Bit Score: 153.71  E-value: 7.49e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818770764   5 TKSPSQTQKLGQKISADITSGrisPVIALSGDLGSGKTTFVQGLAKGLGVTGRIISPTFILMRKYDLPseedknsERTLY 84
Cdd:COG0802    1 LPSEEETEALGARLAALLKPG---DVILLEGDLGAGKTTFVRGLARGLGVTGEVTSPTFTLVNEYELG-------RLPLY 70
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 818770764  85 HVDLYRLEGAldKEILNLGLPYIWSDPSnIVLIEWAEKIKSLIPSGASWITFENMGEALRKITLK 149
Cdd:COG0802   71 HFDLYRLEDP--EELEDLGLEEYLDGDG-VCLIEWPERIEGLLPEDDLEITIEYLGEDGRRITLT 132
 
Name Accession Description Interval E-value
TsaE COG0802
tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE [Translation, ribosomal ...
5-149 7.49e-49

tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE [Translation, ribosomal structure and biogenesis]; tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440565  Cd Length: 146  Bit Score: 153.71  E-value: 7.49e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818770764   5 TKSPSQTQKLGQKISADITSGrisPVIALSGDLGSGKTTFVQGLAKGLGVTGRIISPTFILMRKYDLPseedknsERTLY 84
Cdd:COG0802    1 LPSEEETEALGARLAALLKPG---DVILLEGDLGAGKTTFVRGLARGLGVTGEVTSPTFTLVNEYELG-------RLPLY 70
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 818770764  85 HVDLYRLEGAldKEILNLGLPYIWSDPSnIVLIEWAEKIKSLIPSGASWITFENMGEALRKITLK 149
Cdd:COG0802   71 HFDLYRLEDP--EELEDLGLEEYLDGDG-VCLIEWPERIEGLLPEDDLEITIEYLGEDGRRITLT 132
TsaE pfam02367
Threonylcarbamoyl adenosine biosynthesis protein TsaE; This family of proteins is involved in ...
5-144 7.53e-45

Threonylcarbamoyl adenosine biosynthesis protein TsaE; This family of proteins is involved in the synthesis of threonylcarbamoyl adenosine (t(6)A).


Pssm-ID: 460540  Cd Length: 127  Bit Score: 142.96  E-value: 7.53e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818770764    5 TKSPSQTQKLGQKISADITSGRispVIALSGDLGSGKTTFVQGLAKGLGVTGRIISPTFILMRKYDLPSeedknseRTLY 84
Cdd:pfam02367   1 LNSEEETEALGKRLAALLKPGD---VILLSGDLGAGKTTFTRGLARGLGVTGPVTSPTFTLVNEYEGGG-------LPLY 70
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 818770764   85 HVDLYRLEGAldKEILNLGLPYIWsDPSNIVLIEWAEKIKSLIPSGASWITFENMGEALR 144
Cdd:pfam02367  71 HFDLYRLEDP--EELEDLGLEDYF-DGDGVCLIEWPERIEELLPEDDLDIEIEREGEEGR 127
T6A_YjeE TIGR00150
tRNA threonylcarbamoyl adenosine modification protein YjeE; This protein family belongs to a ...
11-148 4.36e-29

tRNA threonylcarbamoyl adenosine modification protein YjeE; This protein family belongs to a four-gene system responsible for the threonylcarbamoyl adenosine (t6A) tRNA modification. Members of this family have a conserved nucleotide-binding motif GXXGXGKT and a nucleotide-binding fold. Member protein YjeE of Haemophilus influenzae (HI0065) was shown to have (weak) ATPase activity. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129254  Cd Length: 133  Bit Score: 103.29  E-value: 4.36e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818770764   11 TQKLGQKISADitsGRISPVIALSGDLGSGKTTFVQGLAKGLGVTGRIISPTFILMRKYDLpseedknSERTLYHVDLYR 90
Cdd:TIGR00150   8 MDKFGKAFAKP---LDFGTVVLLKGDLGAGKTTLVQGLLQGLGIQGNVTSPTFTLVNEYNE-------GNLMVYHFDLYR 77
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 818770764   91 LEGALDKEIlnLGLPYIWSDPSnIVLIEWAEKIKSLIPSGASWITFENMGEAlRKITL 148
Cdd:TIGR00150  78 LADPEELEL--MGLEDYFEGDG-ICLVEWPEEGLEILPDYDLQIKIDYVGDG-REIEL 131
PRK10646 PRK10646
tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE;
30-129 9.78e-16

tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE;


Pssm-ID: 182615  Cd Length: 153  Bit Score: 69.41  E-value: 9.78e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818770764  30 VIALSGDLGSGKTTFVQGLAKGLGVTGRIISPTFILMRKYDLPSeedknseRTLYHVDLYRLEgalDKEILNLGLPYIWS 109
Cdd:PRK10646  30 VIYLYGDLGAGKTTFSRGFLQALGHQGNVKSPTYTLVEPYTLDN-------LMVYHFDLYRLA---DPEELEFMGIRDYF 99
                         90       100
                 ....*....|....*....|
gi 818770764 110 DPSNIVLIEWAEKIKSLIPS 129
Cdd:PRK10646 100 ANDAICLVEWPQQGAGVLPD 119
 
Name Accession Description Interval E-value
TsaE COG0802
tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE [Translation, ribosomal ...
5-149 7.49e-49

tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE [Translation, ribosomal structure and biogenesis]; tRNA A37 threonylcarbamoyladenosine biosynthesis protein TsaE is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440565  Cd Length: 146  Bit Score: 153.71  E-value: 7.49e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818770764   5 TKSPSQTQKLGQKISADITSGrisPVIALSGDLGSGKTTFVQGLAKGLGVTGRIISPTFILMRKYDLPseedknsERTLY 84
Cdd:COG0802    1 LPSEEETEALGARLAALLKPG---DVILLEGDLGAGKTTFVRGLARGLGVTGEVTSPTFTLVNEYELG-------RLPLY 70
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 818770764  85 HVDLYRLEGAldKEILNLGLPYIWSDPSnIVLIEWAEKIKSLIPSGASWITFENMGEALRKITLK 149
Cdd:COG0802   71 HFDLYRLEDP--EELEDLGLEEYLDGDG-VCLIEWPERIEGLLPEDDLEITIEYLGEDGRRITLT 132
TsaE pfam02367
Threonylcarbamoyl adenosine biosynthesis protein TsaE; This family of proteins is involved in ...
5-144 7.53e-45

Threonylcarbamoyl adenosine biosynthesis protein TsaE; This family of proteins is involved in the synthesis of threonylcarbamoyl adenosine (t(6)A).


Pssm-ID: 460540  Cd Length: 127  Bit Score: 142.96  E-value: 7.53e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818770764    5 TKSPSQTQKLGQKISADITSGRispVIALSGDLGSGKTTFVQGLAKGLGVTGRIISPTFILMRKYDLPSeedknseRTLY 84
Cdd:pfam02367   1 LNSEEETEALGKRLAALLKPGD---VILLSGDLGAGKTTFTRGLARGLGVTGPVTSPTFTLVNEYEGGG-------LPLY 70
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 818770764   85 HVDLYRLEGAldKEILNLGLPYIWsDPSNIVLIEWAEKIKSLIPSGASWITFENMGEALR 144
Cdd:pfam02367  71 HFDLYRLEDP--EELEDLGLEDYF-DGDGVCLIEWPERIEELLPEDDLDIEIEREGEEGR 127
T6A_YjeE TIGR00150
tRNA threonylcarbamoyl adenosine modification protein YjeE; This protein family belongs to a ...
11-148 4.36e-29

tRNA threonylcarbamoyl adenosine modification protein YjeE; This protein family belongs to a four-gene system responsible for the threonylcarbamoyl adenosine (t6A) tRNA modification. Members of this family have a conserved nucleotide-binding motif GXXGXGKT and a nucleotide-binding fold. Member protein YjeE of Haemophilus influenzae (HI0065) was shown to have (weak) ATPase activity. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 129254  Cd Length: 133  Bit Score: 103.29  E-value: 4.36e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818770764   11 TQKLGQKISADitsGRISPVIALSGDLGSGKTTFVQGLAKGLGVTGRIISPTFILMRKYDLpseedknSERTLYHVDLYR 90
Cdd:TIGR00150   8 MDKFGKAFAKP---LDFGTVVLLKGDLGAGKTTLVQGLLQGLGIQGNVTSPTFTLVNEYNE-------GNLMVYHFDLYR 77
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 818770764   91 LEGALDKEIlnLGLPYIWSDPSnIVLIEWAEKIKSLIPSGASWITFENMGEAlRKITL 148
Cdd:TIGR00150  78 LADPEELEL--MGLEDYFEGDG-ICLVEWPEEGLEILPDYDLQIKIDYVGDG-REIEL 131
PRK10646 PRK10646
tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE;
30-129 9.78e-16

tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE;


Pssm-ID: 182615  Cd Length: 153  Bit Score: 69.41  E-value: 9.78e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818770764  30 VIALSGDLGSGKTTFVQGLAKGLGVTGRIISPTFILMRKYDLPSeedknseRTLYHVDLYRLEgalDKEILNLGLPYIWS 109
Cdd:PRK10646  30 VIYLYGDLGAGKTTFSRGFLQALGHQGNVKSPTYTLVEPYTLDN-------LMVYHFDLYRLA---DPEELEFMGIRDYF 99
                         90       100
                 ....*....|....*....|
gi 818770764 110 DPSNIVLIEWAEKIKSLIPS 129
Cdd:PRK10646 100 ANDAICLVEWPQQGAGVLPD 119
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
30-54 1.41e-03

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 37.13  E-value: 1.41e-03
                         10        20
                 ....*....|....*....|....*
gi 818770764  30 VIALSGDLGSGKTTFVQGLAKGLGV 54
Cdd:COG0572    9 IIGIAGPSGSGKTTFARRLAEQLGA 33
Fap7 COG1936
Broad-specificity NMP kinase [Nucleotide transport and metabolism];
30-104 3.17e-03

Broad-specificity NMP kinase [Nucleotide transport and metabolism];


Pssm-ID: 441539 [Multi-domain]  Cd Length: 173  Bit Score: 35.95  E-value: 3.17e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 818770764  30 VIALSGDLGSGKTTFVQGLAKGLGVtgRIISPTFILmRKYDLPSEEDKnsERTLYHVDLYRLEGALDKEILNLGL 104
Cdd:COG1936    2 RIAITGTPGTGKTTVAKLLAERLGL--EVIHLNDLV-KEEGLYTEVDE--ERDSLVVDEDALAEELEELKEGDVI 71
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
28-70 7.19e-03

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 35.94  E-value: 7.19e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 818770764  28 SPVIALSGDLGSGKTTFVQGLA-----KGLGVTGRIisPTFILMRKYD 70
Cdd:COG5635  180 KKRLLILGEPGSGKTTLLRYLAlelaeRYLDAEDPI--PILIELRDLA 225
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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