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Conserved domains on  [gi|818676215|gb|KKT21887|]
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Fic family protein [Candidatus Giovannonibacteria bacterium GW2011_GWC2_43_8]

Protein Classification

HTH_XRE and COG3177 domain-containing protein( domain architecture ID 11513427)

HTH_XRE and COG3177 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3177 COG3177
Fic family protein [Transcription];
83-308 2.31e-48

Fic family protein [Transcription];


:

Pssm-ID: 442410 [Multi-domain]  Cd Length: 316  Bit Score: 164.09  E-value: 2.31e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818676215  83 NNALKEILDNPDILDQFLLSL----TYHSNGIEGSSLTQNETAAILfRNAALPNKNLVEQLEAKNHETALRYLFNYLTtK 158
Cdd:COG3177   12 DEALGRLDGLPEELRELLRKLlieeAYASSAIEGNTLTLDEVRSLL-EGGLTGGPPLRDEREVLNYVEALEYLLELLR-G 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818676215 159 KPINEMLILKLHGILLN---AIRADAGNYRNHPVRITGAYVPtANHLKIPNLIKELIRDLHHSKQ-NVVAKSALFHSCFE 234
Cdd:COG3177   90 EPLTEELILELHRILLKglrGEDKEPGEYRTGQVGIGAVYVP-PPPEEVPELMEELLDWLNEEDElHPLIKAAIAHYQFE 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818676215 235 QIHPFADGNGRIGRLLMHAMLLNAN------LPPAVILQKNRRFYNLYLNKAQMKEDFGGLEDFIVAAILEGYKILERML 308
Cdd:COG3177  169 TIHPFADGNGRTGRLLMNLLLLRAGllsqplLPLSRIIEEDRDEYYDALEAVRETGDLTPWIEFFLEAILEAAEEALALL 248
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 5-54 1.77e-05

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


:

Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 41.77  E-value: 1.77e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 818676215   5 EKLQFIQQLAGLTQTELASRLSVTFAALNRWINFKSIPRKKMLQKIDKLY 54
Cdd:cd00093    2 ERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKAL 51
 
Name Accession Description Interval E-value
COG3177 COG3177
Fic family protein [Transcription];
83-308 2.31e-48

Fic family protein [Transcription];


Pssm-ID: 442410 [Multi-domain]  Cd Length: 316  Bit Score: 164.09  E-value: 2.31e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818676215  83 NNALKEILDNPDILDQFLLSL----TYHSNGIEGSSLTQNETAAILfRNAALPNKNLVEQLEAKNHETALRYLFNYLTtK 158
Cdd:COG3177   12 DEALGRLDGLPEELRELLRKLlieeAYASSAIEGNTLTLDEVRSLL-EGGLTGGPPLRDEREVLNYVEALEYLLELLR-G 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818676215 159 KPINEMLILKLHGILLN---AIRADAGNYRNHPVRITGAYVPtANHLKIPNLIKELIRDLHHSKQ-NVVAKSALFHSCFE 234
Cdd:COG3177   90 EPLTEELILELHRILLKglrGEDKEPGEYRTGQVGIGAVYVP-PPPEEVPELMEELLDWLNEEDElHPLIKAAIAHYQFE 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818676215 235 QIHPFADGNGRIGRLLMHAMLLNAN------LPPAVILQKNRRFYNLYLNKAQMKEDFGGLEDFIVAAILEGYKILERML 308
Cdd:COG3177  169 TIHPFADGNGRTGRLLMNLLLLRAGllsqplLPLSRIIEEDRDEYYDALEAVRETGDLTPWIEFFLEAILEAAEEALALL 248
Fic pfam02661
Fic/DOC family; This family consists of the Fic (filamentation induced by cAMP) protein and ...
 160-255 1.88e-18

Fic/DOC family; This family consists of the Fic (filamentation induced by cAMP) protein and doc (death on curing). The Fic protein is involved in cell division and is suggested to be involved in the synthesis of PAB or folate, indicating that the Fic protein and cAMP are involved in a regulatory mechanism of cell division via folate metabolism. This family contains a central conserved motif HPFXXGNG in most members. The exact molecular function of these proteins is uncertain. P1 lysogens of Escherichia coli carry the prophage as a stable low copy number plasmid. The frequency with which viable cells cured of prophage are produced is about 10(-5) per cell per generation. A significant part of this remarkable stability can be attributed to a plasmid-encoded mechanism that causes death of cells that have lost P1. In other words, the lysogenic cells appear to be addicted to the presence of the prophage. The plasmid withdrawal response depends on a gene named doc (death on curing) that is represented by this family. Doc induces a reversible growth arrest of E. coli cells by targetting the protein synthesis machinery. Doc hosts the C-terminal domain of its antitoxin partner Phd (prevents host death) through fold complementation, a domain that is intrinsically disordered in solution but that folds into an alpha-helix on binding to Doc.This domain forms complexes with Phd antitoxins containing pfam02604.


Pssm-ID: 426907  Cd Length: 94  Bit Score: 78.66  E-value: 1.88e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818676215  160 PINEMLILKLHGILLnAIRADAGNYRNHPVRITGAYVPtANHLKIPNLIKELIRDLHHSKQNVVAKSALFHSCFEQIHPF 239
Cdd:pfam02661   1 YLDLEDLLALHRLLI-ERHGGAGGARDVNVSGLLESAL-ARPEQIPFGLEELLLYPDLDREHPLEKAAALHFGFAKIHPF 78

                          90
                  ....*....|....*.
gi 818676215  240 ADGNGRIGRLLMHAML 255
Cdd:pfam02661  79 RDGNGRTARLLANLFL 94
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 5-54 1.77e-05

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 41.77  E-value: 1.77e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 818676215   5 EKLQFIQQLAGLTQTELASRLSVTFAALNRWINFKSIPRKKMLQKIDKLY 54
Cdd:cd00093    2 ERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKAL 51
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
1-54 8.46e-05

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 39.83  E-value: 8.46e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 818676215   1 MTVKEKLQFIQQLAGLTQTELASRLSVTFAALNRWINFKSIPRKKMLQKIDKLY 54
Cdd:COG1476    3 KKLGNRLKELRKERGLTQEELAELLGVSRQTISAIENGKYNPSLELALKIARAL 56
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
14-54 1.03e-04

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 39.42  E-value: 1.03e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 818676215    14 AGLTQTELASRLSVTFAALNRWINFKSIPRKKMLQKIDKLY 54
Cdd:smart00530   9 KGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKAL 49
XopAC NF041381
XopAC/AvrAC family type III secretion system effector;
223-263 2.06e-04

XopAC/AvrAC family type III secretion system effector;


Pssm-ID: 469272 [Multi-domain]  Cd Length: 453  Bit Score: 42.79  E-value: 2.06e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 818676215 223 VAKSALFHSCFEQIHPFADGNGRIGRLLMHAMLLNANLPPA 263
Cdd:NF041381 381 VERAALLYQALVSLHPFADGNGPTALLAMDWALQRHGLPPV 421
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 12-54 2.64e-04

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 38.29  E-value: 2.64e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 818676215   12 QLAGLTQTELASRLSVTFAALNRWINFKSIPRKKMLQKIDKLY 54
Cdd:pfam01381   6 EELGLSQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEAL 48
PRK14052 PRK14052
adenosine monophosphate-protein transferase vopS;
77-250 4.14e-04

adenosine monophosphate-protein transferase vopS;


Pssm-ID: 184477 [Multi-domain]  Cd Length: 387  Bit Score: 41.48  E-value: 4.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818676215  77 RKQKLHNNALKEILDNPDILDQFLLSLTYHSNGIEGSSLTQNETAAILFRNAALPNK--NLVEQ-----LEAKNHE---- 145
Cdd:PRK14052 181 AAQKNPTNAINQLEAVFDMEVKNLKAAQRHIEGLASTDLSQGVYAEGLAEDAFNKNGvtDNVERaaawiINASTSKgnda 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818676215 146 ---TALryLFNYLTTKKPINEMLILK-LHGILLNAIRADagnYRNHpvRITGAYVPTAnhLKIPNLIKELIRDLhhSKQN 221
Cdd:PRK14052 261 eniTAL--LKEYAHNGKDLLNMDNLKeLHARLVPNIERD---YRGP--AISGGTLPSS--IGGEGMLKQHIEGF--LKEN 329

                        170       180       190
                 ....*....|....*....|....*....|..
gi 818676215 222 VVAKSALFHSCFEQI---HPFADGNGRIGRLL 250
Cdd:PRK14052 330 PVADKDLGKQLFAGVigyHGFTDGNGRMGRML 361
mob_myst_B TIGR02613
mobile mystery protein B; Members of this protein family, which we designate mobile mystery ...
 229-293 6.51e-03

mobile mystery protein B; Members of this protein family, which we designate mobile mystery protein B, are found in mobization-related contexts more often than not, including within a CRISPR-associated gene region in Geobacter sulfurreducens PCA, and on plasmids in Agrobacterium tumefaciens and Coxiella burnetii, always together with mobile mystery protein A (TIGR02612), a member of the family of helix-turn-helix DNA binding proteins (pfam01381). This protein is encoded by the downstream member of the gene pair and belongs to the Fic protein family (pfam02661), where Fic (filamentation induced by cAMP) is a regulator of cell division. The characteristics of having a two-gene operon in a varied context and often on plasmids, with one member affecting cell division and the other able to bind DNA, suggests similarity to addiction modules.


Pssm-ID: 131662  Cd Length: 186  Bit Score: 37.12  E-value: 6.51e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 818676215  229 FHSCFEQIHPFADGNGRIGRLLMHAMLLNANLPP------AVILQKNRRFYNLYLNKAQMKEDFGGLEDFI 293
Cdd:TIGR02613 115 FHHRLVAIHPFPNGNGRHARLATDLLLEQQGYSPftwgsgSLALVGDLRKEYIAALKAADRHDYGPLLEFA 185
 
Name Accession Description Interval E-value
COG3177 COG3177
Fic family protein [Transcription];
83-308 2.31e-48

Fic family protein [Transcription];


Pssm-ID: 442410 [Multi-domain]  Cd Length: 316  Bit Score: 164.09  E-value: 2.31e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818676215  83 NNALKEILDNPDILDQFLLSL----TYHSNGIEGSSLTQNETAAILfRNAALPNKNLVEQLEAKNHETALRYLFNYLTtK 158
Cdd:COG3177   12 DEALGRLDGLPEELRELLRKLlieeAYASSAIEGNTLTLDEVRSLL-EGGLTGGPPLRDEREVLNYVEALEYLLELLR-G 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818676215 159 KPINEMLILKLHGILLN---AIRADAGNYRNHPVRITGAYVPtANHLKIPNLIKELIRDLHHSKQ-NVVAKSALFHSCFE 234
Cdd:COG3177   90 EPLTEELILELHRILLKglrGEDKEPGEYRTGQVGIGAVYVP-PPPEEVPELMEELLDWLNEEDElHPLIKAAIAHYQFE 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818676215 235 QIHPFADGNGRIGRLLMHAMLLNAN------LPPAVILQKNRRFYNLYLNKAQMKEDFGGLEDFIVAAILEGYKILERML 308
Cdd:COG3177  169 TIHPFADGNGRTGRLLMNLLLLRAGllsqplLPLSRIIEEDRDEYYDALEAVRETGDLTPWIEFFLEAILEAAEEALALL 248
Fic pfam02661
Fic/DOC family; This family consists of the Fic (filamentation induced by cAMP) protein and ...
 160-255 1.88e-18

Fic/DOC family; This family consists of the Fic (filamentation induced by cAMP) protein and doc (death on curing). The Fic protein is involved in cell division and is suggested to be involved in the synthesis of PAB or folate, indicating that the Fic protein and cAMP are involved in a regulatory mechanism of cell division via folate metabolism. This family contains a central conserved motif HPFXXGNG in most members. The exact molecular function of these proteins is uncertain. P1 lysogens of Escherichia coli carry the prophage as a stable low copy number plasmid. The frequency with which viable cells cured of prophage are produced is about 10(-5) per cell per generation. A significant part of this remarkable stability can be attributed to a plasmid-encoded mechanism that causes death of cells that have lost P1. In other words, the lysogenic cells appear to be addicted to the presence of the prophage. The plasmid withdrawal response depends on a gene named doc (death on curing) that is represented by this family. Doc induces a reversible growth arrest of E. coli cells by targetting the protein synthesis machinery. Doc hosts the C-terminal domain of its antitoxin partner Phd (prevents host death) through fold complementation, a domain that is intrinsically disordered in solution but that folds into an alpha-helix on binding to Doc.This domain forms complexes with Phd antitoxins containing pfam02604.


Pssm-ID: 426907  Cd Length: 94  Bit Score: 78.66  E-value: 1.88e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818676215  160 PINEMLILKLHGILLnAIRADAGNYRNHPVRITGAYVPtANHLKIPNLIKELIRDLHHSKQNVVAKSALFHSCFEQIHPF 239
Cdd:pfam02661   1 YLDLEDLLALHRLLI-ERHGGAGGARDVNVSGLLESAL-ARPEQIPFGLEELLLYPDLDREHPLEKAAALHFGFAKIHPF 78

                          90
                  ....*....|....*.
gi 818676215  240 ADGNGRIGRLLMHAML 255
Cdd:pfam02661  79 RDGNGRTARLLANLFL 94
FIDO COG2184
Fido, protein-threonine AMPylation domain [Signal transduction mechanisms];
137-261 1.85e-09

Fido, protein-threonine AMPylation domain [Signal transduction mechanisms];


Pssm-ID: 441787 [Multi-domain]  Cd Length: 196  Bit Score: 56.47  E-value: 1.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818676215 137 EQLEAKNHETALRYLFnYLTTKKPINEMLILKLHGILLNAIRADAGNYRNHPVRITGayVPTANHLKIPNLIKELIRDLH 216
Cdd:COG2184   28 DEAEAELTALRAAELF-ERPPPGVFDLAHLKAIHRRLFGDVYDWAGQIRTVNISKGG--TRFAPPSFIERELEALFDDLR 104

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 818676215 217 H-------SKQNVVAKSALFHSCFEQIHPFADGNGRIGRLLMHAMLLNANLP 261
Cdd:COG2184  105 EenylrglDREEFAERLARFHGELNVIHPFREGNGRTQRLFFDQLARQAGYP 156
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 5-54 1.77e-05

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 41.77  E-value: 1.77e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 818676215   5 EKLQFIQQLAGLTQTELASRLSVTFAALNRWINFKSIPRKKMLQKIDKLY 54
Cdd:cd00093    2 ERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKAL 51
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
1-54 8.46e-05

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 39.83  E-value: 8.46e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 818676215   1 MTVKEKLQFIQQLAGLTQTELASRLSVTFAALNRWINFKSIPRKKMLQKIDKLY 54
Cdd:COG1476    3 KKLGNRLKELRKERGLTQEELAELLGVSRQTISAIENGKYNPSLELALKIARAL 56
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
14-54 1.03e-04

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 39.42  E-value: 1.03e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 818676215    14 AGLTQTELASRLSVTFAALNRWINFKSIPRKKMLQKIDKLY 54
Cdd:smart00530   9 KGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKAL 49
XopAC NF041381
XopAC/AvrAC family type III secretion system effector;
223-263 2.06e-04

XopAC/AvrAC family type III secretion system effector;


Pssm-ID: 469272 [Multi-domain]  Cd Length: 453  Bit Score: 42.79  E-value: 2.06e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 818676215 223 VAKSALFHSCFEQIHPFADGNGRIGRLLMHAMLLNANLPPA 263
Cdd:NF041381 381 VERAALLYQALVSLHPFADGNGPTALLAMDWALQRHGLPPV 421
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
1-50 2.08e-04

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 39.21  E-value: 2.08e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 818676215   1 MTVKEKLQFIQQLAGLTQTELASRLSVTFAALNRWINFKSIPRKKMLQKI 50
Cdd:COG1396    6 KALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKL 55
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 12-53 2.41e-04

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 38.77  E-value: 2.41e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 818676215  12 QLAGLTQTELASRLSVTFAALNRWINFKSIPRKKMLQKIDKL 53
Cdd:COG1813   22 EARGLSQEELAEKLGVSESTIRRIERGEATPSLDTLRKLEKA 63
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 12-54 2.64e-04

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 38.29  E-value: 2.64e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 818676215   12 QLAGLTQTELASRLSVTFAALNRWINFKSIPRKKMLQKIDKLY 54
Cdd:pfam01381   6 EELGLSQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEAL 48
YiaG COG2944
DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];
5-52 3.82e-04

DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];


Pssm-ID: 442187 [Multi-domain]  Cd Length: 64  Bit Score: 37.99  E-value: 3.82e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 818676215   5 EKLQFIQQLAGLTQTELASRLSVTFAALNRWINFKSIPR---KKMLQKIDK 52
Cdd:COG2944    9 EEIRALRERLGLSQAEFAALLGVSVSTVRRWEQGRRKPSgaaLKLLRLLEK 59
PRK14052 PRK14052
adenosine monophosphate-protein transferase vopS;
77-250 4.14e-04

adenosine monophosphate-protein transferase vopS;


Pssm-ID: 184477 [Multi-domain]  Cd Length: 387  Bit Score: 41.48  E-value: 4.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818676215  77 RKQKLHNNALKEILDNPDILDQFLLSLTYHSNGIEGSSLTQNETAAILFRNAALPNK--NLVEQ-----LEAKNHE---- 145
Cdd:PRK14052 181 AAQKNPTNAINQLEAVFDMEVKNLKAAQRHIEGLASTDLSQGVYAEGLAEDAFNKNGvtDNVERaaawiINASTSKgnda 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818676215 146 ---TALryLFNYLTTKKPINEMLILK-LHGILLNAIRADagnYRNHpvRITGAYVPTAnhLKIPNLIKELIRDLhhSKQN 221
Cdd:PRK14052 261 eniTAL--LKEYAHNGKDLLNMDNLKeLHARLVPNIERD---YRGP--AISGGTLPSS--IGGEGMLKQHIEGF--LKEN 329

                        170       180       190
                 ....*....|....*....|....*....|..
gi 818676215 222 VVAKSALFHSCFEQI---HPFADGNGRIGRLL 250
Cdd:PRK14052 330 PVADKDLGKQLFAGVigyHGFTDGNGRMGRML 361
mob_myst_B TIGR02613
mobile mystery protein B; Members of this protein family, which we designate mobile mystery ...
 229-293 6.51e-03

mobile mystery protein B; Members of this protein family, which we designate mobile mystery protein B, are found in mobization-related contexts more often than not, including within a CRISPR-associated gene region in Geobacter sulfurreducens PCA, and on plasmids in Agrobacterium tumefaciens and Coxiella burnetii, always together with mobile mystery protein A (TIGR02612), a member of the family of helix-turn-helix DNA binding proteins (pfam01381). This protein is encoded by the downstream member of the gene pair and belongs to the Fic protein family (pfam02661), where Fic (filamentation induced by cAMP) is a regulator of cell division. The characteristics of having a two-gene operon in a varied context and often on plasmids, with one member affecting cell division and the other able to bind DNA, suggests similarity to addiction modules.


Pssm-ID: 131662  Cd Length: 186  Bit Score: 37.12  E-value: 6.51e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 818676215  229 FHSCFEQIHPFADGNGRIGRLLMHAMLLNANLPP------AVILQKNRRFYNLYLNKAQMKEDFGGLEDFI 293
Cdd:TIGR02613 115 FHHRLVAIHPFPNGNGRHARLATDLLLEQQGYSPftwgsgSLALVGDLRKEYIAALKAADRHDYGPLLEFA 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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