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Conserved domains on  [gi|818652406|gb|KKS99011|]
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Addiction module toxin, RelE/StbE family [Candidatus Woesebacteria bacterium GW2011_GWB1_43_14]

Protein Classification

type II toxin-antitoxin system RelE family toxin( domain architecture ID 10005193)

type II toxin-antitoxin (TA) system RelE family toxin is the RelE-like toxin component of a type II toxin-antitoxin system, its activity is attenuated by interaction with its cognate antitoxin

Gene Ontology:  GO:0110001|GO:0004521|GO:0017148
PubMed:  20487277|28279904
SCOP:  4003388

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RelE COG2026
mRNA-degrading endonuclease RelE, toxin component of the RelBE toxin-antitoxin system [Defense ...
 2-81 2.93e-18

mRNA-degrading endonuclease RelE, toxin component of the RelBE toxin-antitoxin system [Defense mechanisms];


:

Pssm-ID: 441629  Cd Length: 85  Bit Score: 71.38  E-value: 2.93e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818652406  2 KLYLSLKAKKQLGKLPTSERRKIEKKFLNLSQDPFL-GKKLSGEFKDCWSLKAWPYRVIYVVDIKKKSVFISSILHRQGA 80
Cdd:COG2026   3 KVEFTPRALKDLKKLDKKVQKRIKKKIEELAENPRPgGKKLKGSLKGLYRLRVGDYRIIYEIDDDELVVLVLAIGHRRDV 82


                .
gi 818652406 81 Y 81
Cdd:COG2026  83 Y 83
 
Name Accession Description Interval E-value
RelE COG2026
mRNA-degrading endonuclease RelE, toxin component of the RelBE toxin-antitoxin system [Defense ...
 2-81 2.93e-18

mRNA-degrading endonuclease RelE, toxin component of the RelBE toxin-antitoxin system [Defense mechanisms];


Pssm-ID: 441629  Cd Length: 85  Bit Score: 71.38  E-value: 2.93e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818652406  2 KLYLSLKAKKQLGKLPTSERRKIEKKFLNLSQDPFL-GKKLSGEFKDCWSLKAWPYRVIYVVDIKKKSVFISSILHRQGA 80
Cdd:COG2026   3 KVEFTPRALKDLKKLDKKVQKRIKKKIEELAENPRPgGKKLKGSLKGLYRLRVGDYRIIYEIDDDELVVLVLAIGHRRDV 82


                .
gi 818652406 81 Y 81
Cdd:COG2026  83 Y 83
ParE_toxin pfam05016
ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II ...
 3-81 1.37e-09

ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.


Pssm-ID: 398610 [Multi-domain]  Cd Length: 91  Bit Score: 49.74  E-value: 1.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818652406   3 LYLSLKAKKQLGKL--------PTSERR---KIEKKFLNLSQDPFLGKKLS-GEFKDCWSLKAWPYRVIYVVDIKKKSVF 70
Cdd:pfam05016  1 VILTPKALKDLKKIadyiaqdnPDAAERflkALEEALELLAENPALGRPLPeGGLKGLRRIRIGDYRIIYRIDDDDLVIL 80

                         90
                 ....*....|.
gi 818652406  71 ISSILHRQGAY 81
Cdd:pfam05016 81 ILRVGHRRRDY 91
 
Name Accession Description Interval E-value
RelE COG2026
mRNA-degrading endonuclease RelE, toxin component of the RelBE toxin-antitoxin system [Defense ...
 2-81 2.93e-18

mRNA-degrading endonuclease RelE, toxin component of the RelBE toxin-antitoxin system [Defense mechanisms];


Pssm-ID: 441629  Cd Length: 85  Bit Score: 71.38  E-value: 2.93e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818652406  2 KLYLSLKAKKQLGKLPTSERRKIEKKFLNLSQDPFL-GKKLSGEFKDCWSLKAWPYRVIYVVDIKKKSVFISSILHRQGA 80
Cdd:COG2026   3 KVEFTPRALKDLKKLDKKVQKRIKKKIEELAENPRPgGKKLKGSLKGLYRLRVGDYRIIYEIDDDELVVLVLAIGHRRDV 82


                .
gi 818652406 81 Y 81
Cdd:COG2026  83 Y 83
ParE_toxin pfam05016
ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II ...
 3-81 1.37e-09

ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.


Pssm-ID: 398610 [Multi-domain]  Cd Length: 91  Bit Score: 49.74  E-value: 1.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818652406   3 LYLSLKAKKQLGKL--------PTSERR---KIEKKFLNLSQDPFLGKKLS-GEFKDCWSLKAWPYRVIYVVDIKKKSVF 70
Cdd:pfam05016  1 VILTPKALKDLKKIadyiaqdnPDAAERflkALEEALELLAENPALGRPLPeGGLKGLRRIRIGDYRIIYRIDDDDLVIL 80

                         90
                 ....*....|.
gi 818652406  71 ISSILHRQGAY 81
Cdd:pfam05016 81 ILRVGHRRRDY 91
ParE COG3668
Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];
22-76 4.19e-05

Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];


Pssm-ID: 442885  Cd Length: 96  Bit Score: 38.33  E-value: 4.19e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 818652406 22 RKIEKKFLNLSQDPFLGKKLSG-EFKDCWSLKAWPYRVIYVVDikKKSVFISSILH 76
Cdd:COG3668  34 DEIEEAIELLAEFPELGRPRPElRVPGLRELVVGPYVIFYRVD--DDTVEILRVLH 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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