MAG: Glycosyl transferase group 1 [Candidatus Magasanikbacteria bacterium GW2011_GWA2_42_32]
Protein Classification
glycosyltransferase family 4 protein( domain architecture ID 10133453)
glycosyltransferase family 4 (GT4) protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||
| GT4_PimA-like | cd03801 | phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ... |
2-349 | 6.08e-55 | ||||||
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea. : Pssm-ID: 340831 [Multi-domain] Cd Length: 366 Bit Score: 183.89 E-value: 6.08e-55
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| Name | Accession | Description | Interval | E-value | ||||||
| GT4_PimA-like | cd03801 | phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ... |
2-349 | 6.08e-55 | ||||||
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea. Pssm-ID: 340831 [Multi-domain] Cd Length: 366 Bit Score: 183.89 E-value: 6.08e-55
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| Glycos_transf_1 | pfam00534 | Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ... |
167-331 | 1.22e-37 | ||||||
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family. Pssm-ID: 425737 [Multi-domain] Cd Length: 158 Bit Score: 132.40 E-value: 1.22e-37
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| RfaB | COG0438 | Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ... |
240-353 | 6.20e-26 | ||||||
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 440207 [Multi-domain] Cd Length: 123 Bit Score: 100.45 E-value: 6.20e-26
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| PLN02871 | PLN02871 | UDP-sulfoquinovose:DAG sulfoquinovosyltransferase |
65-336 | 3.94e-12 | ||||||
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase Pssm-ID: 215469 [Multi-domain] Cd Length: 465 Bit Score: 67.04 E-value: 3.94e-12
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| MSMEG_0565_glyc | TIGR04047 | glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from ... |
144-348 | 2.14e-11 | ||||||
glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from Actinobacteria to Proteobacteria to Cyanobacteria features a radical SAM protein, an N-acetyltransferase, an oxidoreductase, and two additional proteins whose functional classes are unclear. The metabolic role of the cluster is probably biosynthetic. This glycosyltransferase, named from member MSMEG_0565 from Mycobacterium smegmatis, occurs in most but not all instances of the cluster. [Unknown function, Enzymes of unknown specificity] Pssm-ID: 274943 [Multi-domain] Cd Length: 373 Bit Score: 64.34 E-value: 2.14e-11
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| PelF | NF038011 | GT4 family glycosyltransferase PelF; Proteins of this family are components of the ... |
186-317 | 5.99e-09 | ||||||
GT4 family glycosyltransferase PelF; Proteins of this family are components of the exopolysaccharide Pel transporter. It has been reported that PelF is a soluble glycosyltransferase that uses UDP-glucose as the substrate for the synthesis of exopolysaccharide Pel, whereas PelG is a Wzx-like and PST family exopolysaccharide transporter. Pssm-ID: 411604 [Multi-domain] Cd Length: 489 Bit Score: 57.25 E-value: 5.99e-09
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| Name | Accession | Description | Interval | E-value | ||||||
| GT4_PimA-like | cd03801 | phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ... |
2-349 | 6.08e-55 | ||||||
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea. Pssm-ID: 340831 [Multi-domain] Cd Length: 366 Bit Score: 183.89 E-value: 6.08e-55
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| GT4_CapM-like | cd03808 | capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ... |
21-329 | 2.37e-39 | ||||||
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides. Pssm-ID: 340837 [Multi-domain] Cd Length: 358 Bit Score: 142.73 E-value: 2.37e-39
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| Glycos_transf_1 | pfam00534 | Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ... |
167-331 | 1.22e-37 | ||||||
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family. Pssm-ID: 425737 [Multi-domain] Cd Length: 158 Bit Score: 132.40 E-value: 1.22e-37
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| GT4_MtfB-like | cd03809 | glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ... |
102-346 | 1.99e-37 | ||||||
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide. Pssm-ID: 340838 [Multi-domain] Cd Length: 362 Bit Score: 137.88 E-value: 1.99e-37
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| GT4_AmsD-like | cd03820 | amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ... |
35-346 | 3.05e-36 | ||||||
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran. Pssm-ID: 340847 [Multi-domain] Cd Length: 351 Bit Score: 134.29 E-value: 3.05e-36
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| GT4_WlbH-like | cd03798 | Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ... |
45-351 | 2.02e-35 | ||||||
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS. Pssm-ID: 340828 [Multi-domain] Cd Length: 376 Bit Score: 132.50 E-value: 2.02e-35
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| GT4_UGDG-like | cd03817 | UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ... |
52-351 | 2.00e-33 | ||||||
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol. Pssm-ID: 340844 [Multi-domain] Cd Length: 372 Bit Score: 127.01 E-value: 2.00e-33
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| GT4_WfcD-like | cd03795 | Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ... |
43-327 | 2.10e-33 | ||||||
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes. Pssm-ID: 340826 [Multi-domain] Cd Length: 355 Bit Score: 126.62 E-value: 2.10e-33
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| GT4_GT28_WabH-like | cd03811 | family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ... |
17-323 | 2.16e-32 | ||||||
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core. Pssm-ID: 340839 [Multi-domain] Cd Length: 351 Bit Score: 124.01 E-value: 2.16e-32
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| GT4_sucrose_synthase | cd03800 | sucrose-phosphate synthase and similar proteins; This family is most closely related to the ... |
142-346 | 6.46e-27 | ||||||
sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light. Pssm-ID: 340830 [Multi-domain] Cd Length: 398 Bit Score: 109.64 E-value: 6.46e-27
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| GT4_mannosyltransferase-like | cd03822 | mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most ... |
167-349 | 3.09e-26 | ||||||
mannosyltransferases of glycosyltransferase family 4 and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides. Pssm-ID: 340849 [Multi-domain] Cd Length: 370 Bit Score: 107.47 E-value: 3.09e-26
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| RfaB | COG0438 | Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ... |
240-353 | 6.20e-26 | ||||||
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 440207 [Multi-domain] Cd Length: 123 Bit Score: 100.45 E-value: 6.20e-26
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| Glyco_trans_1_4 | pfam13692 | Glycosyl transferases group 1; |
167-317 | 1.68e-25 | ||||||
Glycosyl transferases group 1; Pssm-ID: 463957 [Multi-domain] Cd Length: 138 Bit Score: 99.51 E-value: 1.68e-25
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| GT4-like | cd03813 | glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ... |
115-349 | 6.69e-24 | ||||||
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes. Pssm-ID: 340841 [Multi-domain] Cd Length: 474 Bit Score: 102.03 E-value: 6.69e-24
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| GT4_WbuB-like | cd03794 | Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ... |
40-345 | 7.97e-24 | ||||||
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase. Pssm-ID: 340825 [Multi-domain] Cd Length: 391 Bit Score: 100.88 E-value: 7.97e-24
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| GT4_AmsK-like | cd03799 | Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ... |
46-324 | 1.56e-23 | ||||||
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor. Pssm-ID: 340829 [Multi-domain] Cd Length: 350 Bit Score: 99.45 E-value: 1.56e-23
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| GT4_BshA-like | cd04962 | N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ... |
51-351 | 1.03e-21 | ||||||
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes. Pssm-ID: 340859 [Multi-domain] Cd Length: 370 Bit Score: 94.73 E-value: 1.03e-21
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| GT4_WbnK-like | cd03807 | Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ... |
17-319 | 1.35e-21 | ||||||
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis. Pssm-ID: 340836 [Multi-domain] Cd Length: 362 Bit Score: 94.31 E-value: 1.35e-21
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| GT4-like | cd05844 | glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ... |
96-324 | 9.40e-21 | ||||||
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. Pssm-ID: 340860 [Multi-domain] Cd Length: 365 Bit Score: 92.13 E-value: 9.40e-21
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| GT4_GtfA-like | cd04949 | accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ... |
158-344 | 1.15e-20 | ||||||
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria. Pssm-ID: 340855 [Multi-domain] Cd Length: 328 Bit Score: 91.21 E-value: 1.15e-20
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| Glycosyltransferase_GTB-type | cd01635 | glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ... |
26-299 | 1.30e-20 | ||||||
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. Pssm-ID: 340816 [Multi-domain] Cd Length: 235 Bit Score: 89.39 E-value: 1.30e-20
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| GT4_Bme6-like | cd03821 | Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ... |
51-346 | 3.19e-19 | ||||||
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide. Pssm-ID: 340848 [Multi-domain] Cd Length: 377 Bit Score: 87.81 E-value: 3.19e-19
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| GT4-like | cd03814 | glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ... |
48-349 | 6.09e-19 | ||||||
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes. Pssm-ID: 340842 [Multi-domain] Cd Length: 365 Bit Score: 86.58 E-value: 6.09e-19
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| GT4_ALG2-like | cd03805 | alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely ... |
103-335 | 2.91e-18 | ||||||
alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans. Pssm-ID: 340834 [Multi-domain] Cd Length: 392 Bit Score: 84.95 E-value: 2.91e-18
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| GT4_WbdM_like | cd04951 | LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ... |
116-344 | 1.01e-17 | ||||||
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria. Pssm-ID: 340857 [Multi-domain] Cd Length: 360 Bit Score: 83.26 E-value: 1.01e-17
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| GT4_WcaC-like | cd03825 | putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ... |
114-351 | 1.66e-16 | ||||||
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis. Pssm-ID: 340851 [Multi-domain] Cd Length: 364 Bit Score: 79.68 E-value: 1.66e-16
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| GT4_WavL-like | cd03819 | Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ... |
52-330 | 2.30e-15 | ||||||
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core. Pssm-ID: 340846 [Multi-domain] Cd Length: 345 Bit Score: 76.24 E-value: 2.30e-15
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| GT4_ExpE7-like | cd03823 | glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ... |
117-349 | 3.14e-15 | ||||||
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II). Pssm-ID: 340850 [Multi-domain] Cd Length: 357 Bit Score: 75.83 E-value: 3.14e-15
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| GT4_CapH-like | cd03812 | capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ... |
33-353 | 1.66e-13 | ||||||
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1). Pssm-ID: 340840 [Multi-domain] Cd Length: 357 Bit Score: 70.78 E-value: 1.66e-13
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| GT4_PIG-A-like | cd03796 | phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This ... |
111-353 | 1.20e-12 | ||||||
phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate in glycosyl phosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is an important cellular structure that facilitates the attachment of many proteins to cell surfaces. Somatic mutations in PIG-A have been associated with Paroxysmal Nocturnal Hemoglobinuria (PNH), an acquired hematological disorder. Pssm-ID: 340827 [Multi-domain] Cd Length: 398 Bit Score: 68.42 E-value: 1.20e-12
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| PLN02871 | PLN02871 | UDP-sulfoquinovose:DAG sulfoquinovosyltransferase |
65-336 | 3.94e-12 | ||||||
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase Pssm-ID: 215469 [Multi-domain] Cd Length: 465 Bit Score: 67.04 E-value: 3.94e-12
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| MSMEG_0565_glyc | TIGR04047 | glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from ... |
144-348 | 2.14e-11 | ||||||
glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from Actinobacteria to Proteobacteria to Cyanobacteria features a radical SAM protein, an N-acetyltransferase, an oxidoreductase, and two additional proteins whose functional classes are unclear. The metabolic role of the cluster is probably biosynthetic. This glycosyltransferase, named from member MSMEG_0565 from Mycobacterium smegmatis, occurs in most but not all instances of the cluster. [Unknown function, Enzymes of unknown specificity] Pssm-ID: 274943 [Multi-domain] Cd Length: 373 Bit Score: 64.34 E-value: 2.14e-11
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| Glyco_transf_4 | pfam13439 | Glycosyltransferase Family 4; |
43-152 | 4.78e-11 | ||||||
Glycosyltransferase Family 4; Pssm-ID: 463877 [Multi-domain] Cd Length: 169 Bit Score: 60.62 E-value: 4.78e-11
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| GT4_ALG11-like | cd03806 | alpha-1,2-mannosyltransferase ALG11 and similar proteins; This family is most closely related ... |
103-275 | 3.14e-10 | ||||||
alpha-1,2-mannosyltransferase ALG11 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG11 in yeast is involved in adding the final 1,2-linked Man to the Man5GlcNAc2-PP-Dol synthesized on the cytosolic face of the ER. The deletion analysis of ALG11 was shown to block the early steps of core biosynthesis that takes place on the cytoplasmic face of the ER and lead to a defect in the assembly of lipid-linked oligosaccharides. Pssm-ID: 340835 [Multi-domain] Cd Length: 419 Bit Score: 61.09 E-value: 3.14e-10
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| GT4_WbaZ-like | cd03804 | mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 ... |
91-331 | 1.45e-09 | ||||||
mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbaZ in Salmonella enterica has been shown to possess mannosyltransferase activity. Pssm-ID: 340833 [Multi-domain] Cd Length: 356 Bit Score: 58.84 E-value: 1.45e-09
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| PelF | NF038011 | GT4 family glycosyltransferase PelF; Proteins of this family are components of the ... |
186-317 | 5.99e-09 | ||||||
GT4 family glycosyltransferase PelF; Proteins of this family are components of the exopolysaccharide Pel transporter. It has been reported that PelF is a soluble glycosyltransferase that uses UDP-glucose as the substrate for the synthesis of exopolysaccharide Pel, whereas PelG is a Wzx-like and PST family exopolysaccharide transporter. Pssm-ID: 411604 [Multi-domain] Cd Length: 489 Bit Score: 57.25 E-value: 5.99e-09
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| PRK15179 | PRK15179 | Vi polysaccharide biosynthesis protein TviE; Provisional |
160-334 | 3.60e-08 | ||||||
Vi polysaccharide biosynthesis protein TviE; Provisional Pssm-ID: 185101 [Multi-domain] Cd Length: 694 Bit Score: 55.04 E-value: 3.60e-08
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| GT4_ExpC-like | cd03818 | Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 ... |
142-328 | 2.63e-07 | ||||||
Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II). Pssm-ID: 340845 [Multi-domain] Cd Length: 396 Bit Score: 51.98 E-value: 2.63e-07
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| GT4_trehalose_phosphorylase | cd03792 | trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly ... |
167-327 | 5.87e-07 | ||||||
trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose, and the subsequent synthesis of trehalose. This family is most closely related to the GT4 family of glycosyltransferases. Pssm-ID: 340823 [Multi-domain] Cd Length: 378 Bit Score: 50.78 E-value: 5.87e-07
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| GT4_AviGT4-like | cd03802 | UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ... |
144-351 | 1.24e-06 | ||||||
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue. Pssm-ID: 340832 [Multi-domain] Cd Length: 333 Bit Score: 49.59 E-value: 1.24e-06
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| PRK15484 | PRK15484 | lipopolysaccharide N-acetylglucosaminyltransferase; |
121-346 | 1.54e-06 | ||||||
lipopolysaccharide N-acetylglucosaminyltransferase; Pssm-ID: 185381 [Multi-domain] Cd Length: 380 Bit Score: 49.40 E-value: 1.54e-06
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| PRK09922 | PRK09922 | lipopolysaccharide 1,6-galactosyltransferase; |
119-313 | 6.75e-06 | ||||||
lipopolysaccharide 1,6-galactosyltransferase; Pssm-ID: 182148 [Multi-domain] Cd Length: 359 Bit Score: 47.40 E-value: 6.75e-06
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| sucrsPsyn_pln | TIGR02468 | sucrose phosphate synthase/possible sucrose phosphate phosphatase, plant; Members of this ... |
261-327 | 3.23e-04 | ||||||
sucrose phosphate synthase/possible sucrose phosphate phosphatase, plant; Members of this family are sucrose-phosphate synthases of plants. This enzyme is known to exist in multigene families in several species of both monocots and dicots. The N-terminal domain is the glucosyltransferase domain. Members of this family also have a variable linker region and a C-terminal domain that resembles sucrose phosphate phosphatase (SPP) (EC 3.1.3.24) (see TIGR01485), the next and final enzyme of sucrose biosynthesis. The SPP-like domain likely serves a binding and not a catalytic function, as the reported SPP is always encoded by a distinct protein. Pssm-ID: 274147 [Multi-domain] Cd Length: 1050 Bit Score: 42.85 E-value: 3.23e-04
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| PLN02949 | PLN02949 | transferase, transferring glycosyl groups |
150-275 | 1.02e-03 | ||||||
transferase, transferring glycosyl groups Pssm-ID: 215511 [Multi-domain] Cd Length: 463 Bit Score: 40.88 E-value: 1.02e-03
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