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Conserved domains on  [gi|818283614|gb|KKP69018|]
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MAG: Ribose-phosphate pyrophosphokinase [Candidatus Moranbacteria bacterium GW2011_GWE1_35_17]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02297 super family cl31859
ribose-phosphate pyrophosphokinase
 1-300 7.19e-140

ribose-phosphate pyrophosphokinase


The actual alignment was detected with superfamily member PLN02297:

Pssm-ID: 177934 [Multi-domain]  Cd Length: 326  Bit Score: 397.91  E-value: 7.19e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614   1 MSKKIIFAHESVSDLAKTIDDLMDA-ELGSISWEKFGDGWPELFINQADEIRNKDIVFVANFAKPETLFEQFAIIYSLPR 79
Cdd:PLN02297  14 KKQVHLFYCEETEELARKIAAESDAiELGSINWRKFPDGFPNLFINNAHGIRGQHVAFLASFSSPAVIFEQLSVIYALPK 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614  80 HFVRSLRVIVLFYPVGTMERVDTYGDIATAETMARMISATPMTQTGPVIFSIFDIHALQGQFYFSDKILPELVSAIPLLK 159
Cdd:PLN02297  94 LFVASFTLVLPFFPTGTSERVEREGDVATAFTLARILSNIPISRGGPTSLVIFDIHALQERFYFGDNVLPCFESGIPLLK 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614 160 ERIKSI---ENLAIAFPDDGAYKRFGKMFPEYPHIICNKVRMSDgEKIVTIKEGAVEGKHVIIIDDLVQTGGTLLECREV 236
Cdd:PLN02297 174 KRLQQLpdsDNIVIAFPDDGAWKRFHKQFEHFPMVVCTKVREGD-KRIVRIKEGNPAGRHVVIVDDLVQSGGTLIECQKV 252

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614 237 LLHSGAKEVSAYATHGVFPKDSWKNFLP------NLFSHIWITDSCPDTIKKISAEKEFEILSLAPSIAE 300
Cdd:PLN02297 253 LAAHGAAKVSAYVTHGVFPNESWERFTHdnggpeAGFAYFWITDSCPQTVKAVRGKAPFEVLSLAGSIAD 322
 
Name Accession Description Interval E-value
PLN02297 PLN02297
ribose-phosphate pyrophosphokinase
 1-300 7.19e-140

ribose-phosphate pyrophosphokinase


Pssm-ID: 177934 [Multi-domain]  Cd Length: 326  Bit Score: 397.91  E-value: 7.19e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614   1 MSKKIIFAHESVSDLAKTIDDLMDA-ELGSISWEKFGDGWPELFINQADEIRNKDIVFVANFAKPETLFEQFAIIYSLPR 79
Cdd:PLN02297  14 KKQVHLFYCEETEELARKIAAESDAiELGSINWRKFPDGFPNLFINNAHGIRGQHVAFLASFSSPAVIFEQLSVIYALPK 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614  80 HFVRSLRVIVLFYPVGTMERVDTYGDIATAETMARMISATPMTQTGPVIFSIFDIHALQGQFYFSDKILPELVSAIPLLK 159
Cdd:PLN02297  94 LFVASFTLVLPFFPTGTSERVEREGDVATAFTLARILSNIPISRGGPTSLVIFDIHALQERFYFGDNVLPCFESGIPLLK 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614 160 ERIKSI---ENLAIAFPDDGAYKRFGKMFPEYPHIICNKVRMSDgEKIVTIKEGAVEGKHVIIIDDLVQTGGTLLECREV 236
Cdd:PLN02297 174 KRLQQLpdsDNIVIAFPDDGAWKRFHKQFEHFPMVVCTKVREGD-KRIVRIKEGNPAGRHVVIVDDLVQSGGTLIECQKV 252

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614 237 LLHSGAKEVSAYATHGVFPKDSWKNFLP------NLFSHIWITDSCPDTIKKISAEKEFEILSLAPSIAE 300
Cdd:PLN02297 253 LAAHGAAKVSAYVTHGVFPNESWERFTHdnggpeAGFAYFWITDSCPQTVKAVRGKAPFEVLSLAGSIAD 322
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 1-303 4.96e-42

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 147.13  E-value: 4.96e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614   1 MSKKIIFAHESVSDLAKTIDDLMDAELGSISWEKFGDGwpELFINQADEIRNKDIVFVANFAKP--ETLFEQFAIIYSLP 78
Cdd:COG0462    1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDG--EIYVRIEESVRGRDVFVIQSTSPPvnDNLMELLIMIDALK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614  79 RHFVRSLRVIVLFYPVGTMERVDTYGDIATAETMARMISATP----MTqtgpvifsiFDIHALQGQFYFSdkILPELVSA 154
Cdd:COG0462   79 RASARRITAVIPYYGYARQDRKFRPREPITAKLVADLLEAAGadrvLT---------VDLHAPQIQGFFD--IPVDHLYA 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614 155 IPLLKERIKS--IENLAIAFPDDGAYKR---FGKMFpEYPHIICNKVRMSDGEKIVTIKEGAVEGKHVIIIDDLVQTGGT 229
Cdd:COG0462  148 APLLADYIKSkdLEDLVVVSPDVGGVKRaraFAKRL-GAPLAIIDKRRPGANEVEVMNIIGDVEGKTCIIVDDMIDTGGT 226

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 818283614 230 LLECREVLLHSGAKEVSAYATHGVFPKDSWKNFLPNLFSHIWITDSCPdtikkISAEKEFE---ILSLAPSIAEIIK 303
Cdd:COG0462  227 LVEAAEALKEAGAKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIP-----LPEEKRCDkikVLSVAPLLAEAIR 298
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 5-304 5.79e-36

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 131.25  E-value: 5.79e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614    5 IIFAHESVSDLAKTIDDLMDAELGSISWEKFGDGwpELFINQADEIRNKDIVFVANFAKPET---LFEQFAIIYSLPRHF 81
Cdd:TIGR01251   2 KIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDG--ELYVRINESVRGKDVFIIQQSTSAPVndnLMELLIMIDALKRAS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614   82 VRSLRVIVLFYPVGTMERVDTYGDIATAETMARMISATPMTQtgpVIfsIFDIHALQGQFYFsdKILPELVSAIPLLKER 161
Cdd:TIGR01251  80 AKSITAVIPYYGYARQDKKFKSREPISAKLVANLLETAGADR---VL--TVDLHSPQIQGFF--DVPVDNLYASPVLAEY 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614  162 IKSI--ENLAIAFPDDGAYKRFGKMFP----EYPHIicNKVRMS-DGEKIVTIKEGAVEGKHVIIIDDLVQTGGTLLECR 234
Cdd:TIGR01251 153 LKKKilDNPVVVSPDAGGVERAKKVADalgcPLAII--DKRRISaTNEVEVMNLVGDVEGKDVVIVDDIIDTGGTIAKAA 230

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614  235 EVLLHSGAKEVSAYATHGVFPKDSWKNFLPNLFSHIWITdscpDTIKKISAEKEFEILSLAPSIAEIIKD 304
Cdd:TIGR01251 231 EILKSAGAKRVIAAATHGVFSGPAIERIANAGVEEVIVT----NTIPHEKHKPKVSVISVAPLIAEAIRR 296
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 154-265 5.11e-14

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 67.81  E-value: 5.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614 154 AIPLLKERIKS--IENLAIAFPDDGAYKRFGKMFPEY--PHIICNKVRMSDGEKIVT------IKEGAVEGKHVIIIDDL 223
Cdd:cd06223    1 AGRLLAEEIREdlLEPDVVVGILRGGLPLAAALARALglPLAFIRKERKGPGRTPSEpyglelPLGGDVKGKRVLLVDDV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 818283614 224 VQTGGTLLECREVLLHSGAKEVSAYATHGVFPKDSWKNFLPN 265
Cdd:cd06223   81 IATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGARELASPG 122
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 5-118 9.34e-09

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 52.42  E-value: 9.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614    5 IIFAHESVSDLAKTIDDLMDAELGSISWEKFGDGwpELFINQADEIRNKDIVFVANFAKP--ETLFEQFAIIYSLPRHFV 82
Cdd:pfam13793   2 KIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDG--EIYVRIEESVRGKDVFIIQSTCPPvnDNLMELLIMIDALKRASA 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 818283614   83 RSLRVIVLFYPVGTMERVDTYGDIATAETMARMISA 118
Cdd:pfam13793  80 KRITAVIPYFGYARQDRKDKPREPITAKLVADLLEA 115
 
Name Accession Description Interval E-value
PLN02297 PLN02297
ribose-phosphate pyrophosphokinase
 1-300 7.19e-140

ribose-phosphate pyrophosphokinase


Pssm-ID: 177934 [Multi-domain]  Cd Length: 326  Bit Score: 397.91  E-value: 7.19e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614   1 MSKKIIFAHESVSDLAKTIDDLMDA-ELGSISWEKFGDGWPELFINQADEIRNKDIVFVANFAKPETLFEQFAIIYSLPR 79
Cdd:PLN02297  14 KKQVHLFYCEETEELARKIAAESDAiELGSINWRKFPDGFPNLFINNAHGIRGQHVAFLASFSSPAVIFEQLSVIYALPK 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614  80 HFVRSLRVIVLFYPVGTMERVDTYGDIATAETMARMISATPMTQTGPVIFSIFDIHALQGQFYFSDKILPELVSAIPLLK 159
Cdd:PLN02297  94 LFVASFTLVLPFFPTGTSERVEREGDVATAFTLARILSNIPISRGGPTSLVIFDIHALQERFYFGDNVLPCFESGIPLLK 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614 160 ERIKSI---ENLAIAFPDDGAYKRFGKMFPEYPHIICNKVRMSDgEKIVTIKEGAVEGKHVIIIDDLVQTGGTLLECREV 236
Cdd:PLN02297 174 KRLQQLpdsDNIVIAFPDDGAWKRFHKQFEHFPMVVCTKVREGD-KRIVRIKEGNPAGRHVVIVDDLVQSGGTLIECQKV 252

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614 237 LLHSGAKEVSAYATHGVFPKDSWKNFLP------NLFSHIWITDSCPDTIKKISAEKEFEILSLAPSIAE 300
Cdd:PLN02297 253 LAAHGAAKVSAYVTHGVFPNESWERFTHdnggpeAGFAYFWITDSCPQTVKAVRGKAPFEVLSLAGSIAD 322
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 1-303 4.96e-42

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 147.13  E-value: 4.96e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614   1 MSKKIIFAHESVSDLAKTIDDLMDAELGSISWEKFGDGwpELFINQADEIRNKDIVFVANFAKP--ETLFEQFAIIYSLP 78
Cdd:COG0462    1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDG--EIYVRIEESVRGRDVFVIQSTSPPvnDNLMELLIMIDALK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614  79 RHFVRSLRVIVLFYPVGTMERVDTYGDIATAETMARMISATP----MTqtgpvifsiFDIHALQGQFYFSdkILPELVSA 154
Cdd:COG0462   79 RASARRITAVIPYYGYARQDRKFRPREPITAKLVADLLEAAGadrvLT---------VDLHAPQIQGFFD--IPVDHLYA 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614 155 IPLLKERIKS--IENLAIAFPDDGAYKR---FGKMFpEYPHIICNKVRMSDGEKIVTIKEGAVEGKHVIIIDDLVQTGGT 229
Cdd:COG0462  148 APLLADYIKSkdLEDLVVVSPDVGGVKRaraFAKRL-GAPLAIIDKRRPGANEVEVMNIIGDVEGKTCIIVDDMIDTGGT 226

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 818283614 230 LLECREVLLHSGAKEVSAYATHGVFPKDSWKNFLPNLFSHIWITDSCPdtikkISAEKEFE---ILSLAPSIAEIIK 303
Cdd:COG0462  227 LVEAAEALKEAGAKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIP-----LPEEKRCDkikVLSVAPLLAEAIR 298
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 5-304 5.79e-36

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 131.25  E-value: 5.79e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614    5 IIFAHESVSDLAKTIDDLMDAELGSISWEKFGDGwpELFINQADEIRNKDIVFVANFAKPET---LFEQFAIIYSLPRHF 81
Cdd:TIGR01251   2 KIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDG--ELYVRINESVRGKDVFIIQQSTSAPVndnLMELLIMIDALKRAS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614   82 VRSLRVIVLFYPVGTMERVDTYGDIATAETMARMISATPMTQtgpVIfsIFDIHALQGQFYFsdKILPELVSAIPLLKER 161
Cdd:TIGR01251  80 AKSITAVIPYYGYARQDKKFKSREPISAKLVANLLETAGADR---VL--TVDLHSPQIQGFF--DVPVDNLYASPVLAEY 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614  162 IKSI--ENLAIAFPDDGAYKRFGKMFP----EYPHIicNKVRMS-DGEKIVTIKEGAVEGKHVIIIDDLVQTGGTLLECR 234
Cdd:TIGR01251 153 LKKKilDNPVVVSPDAGGVERAKKVADalgcPLAII--DKRRISaTNEVEVMNLVGDVEGKDVVIVDDIIDTGGTIAKAA 230

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614  235 EVLLHSGAKEVSAYATHGVFPKDSWKNFLPNLFSHIWITdscpDTIKKISAEKEFEILSLAPSIAEIIKD 304
Cdd:TIGR01251 231 EILKSAGAKRVIAAATHGVFSGPAIERIANAGVEEVIVT----NTIPHEKHKPKVSVISVAPLIAEAIRR 296
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
6-303 6.77e-32

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 120.22  E-value: 6.77e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614   6 IFAHESVSDLAKTIDDLMDAELGSISWEKFGDGwpELFINQADEIRNKDIVFVANFAKP--ETLFEQFAIIYSLPRHFVR 83
Cdd:PRK01259   3 LFAGNANPELAEKIAKYLGIPLGKASVGRFSDG--EISVEINENVRGKDVFIIQSTCAPtnDNLMELLIMIDALKRASAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614  84 SLRVIVLFYPVGTMERVDTYGDIATAETMARMISATPMTQtgpVIfsIFDIHALQGQFYFsDKILPELVSAIPLLKE-RI 162
Cdd:PRK01259  81 RITAVIPYFGYARQDRKARSRVPITAKLVANLLETAGADR---VL--TMDLHADQIQGFF-DIPVDNLYGSPILLEDiKQ 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614 163 KSIENLAIAFPDDGAYKR---FGKMFpEYPHIICNKVRMSDGEKIVTIKEGAVEGKHVIIIDDLVQTGGTLLECREVLLH 239
Cdd:PRK01259 155 KNLENLVVVSPDVGGVVRaraLAKRL-DADLAIIDKRRPRANVSEVMNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKE 233

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 818283614 240 SGAKEVSAYATHGVFPKDSWKNFLPNLFSHIWITDSCPDTIKKISAEKeFEILSLAPSIAEIIK 303
Cdd:PRK01259 234 RGAKSVYAYATHPVLSGGAIERIENSVIDELVVTDSIPLSEEAKKCDK-IRVLSVAPLLAEAIR 296
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 5-304 7.74e-28

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 108.85  E-value: 7.74e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614   5 IIFAHESVSDLAKTIDDLMDAELGSISWEKFGDGwpELFINQADEIRNKDIVFVANFA-KPETLFEQFAIIYSLPRHFVR 83
Cdd:PRK00934   1 MIIGGSASQLLASEVARLLNTELALVETKRFPDG--ELYVRILGEIDGEDVVIISTTYpQDENLVELLLLIDALRDEGAK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614  84 SLRVIVLFYPVGTMERVDTYGDIATAETMARMISATpmtqtGPVIFSIfDIHALQGQFYFsdKILPELVSAIPLLKERIK 163
Cdd:PRK00934  79 SITLVIPYLGYARQDKRFKPGEPISARAIAKIISAY-----YDRIITI-NIHEPSILEFF--PIPFINLDAAPLIAEYIG 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614 164 S-IENLAIAFPDDGAYKR-------FGKmfpEYPHIicNKVRMSDGEKIVTIKEGAVEGKHVIIIDDLVQTGGTLLECRE 235
Cdd:PRK00934 151 DkLDDPLVLAPDKGALELakeaaeiLGC---EYDYL--EKTRISPTEVEIAPKNLDVKGKDVLIVDDIISTGGTMATAIK 225

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 818283614 236 VLLHSGAKEVSAYATHGVFPKDSWKNFLPNLFSHIWITdscpDTIkkisaEKEFEILSLAPSIAEIIKD 304
Cdd:PRK00934 226 ILKEQGAKKVYVACVHPVLVGDAILKLYNAGVDEIIVT----DTL-----ESEVSKISVAPLIADLLKK 285
PRK00553 PRK00553
ribose-phosphate pyrophosphokinase; Provisional
 2-302 6.30e-27

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 179062 [Multi-domain]  Cd Length: 332  Bit Score: 107.70  E-value: 6.30e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614   2 SKKIIFAHESVSDLAKTIDDLMDAELGSISWEKFGDGwpELFINQADEIRNKDIVFVANFAKP--ETLFEQFAIIYSLPR 79
Cdd:PRK00553   8 SNHVIFSLSKAKKLVDSICRKLSMKPGEIVIQKFADG--ETYIRFDESVRNKDVVIFQSTCSPvnDSLMELLIAIDALKR 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614  80 HFVRSLRVIVLFYPVGTMERVDTYGDIATAETMARMisatpMTQTGPVIFSIFDIHALQGQFYFsDKILPELVSAIPLLK 159
Cdd:PRK00553  86 GSAKSITAILPYYGYARQDRKTAGREPITSKLVADL-----LTKAGVTRVTLTDIHSDQTQGFF-DIPVDILRTYHVFLS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614 160 ERIK--SIENLAIAFPDDGAYKRFGKMFP--EYPHIICNKVRMSD--GEKIVTIkeGAVEGKHVIIIDDLVQTGGTLLEC 233
Cdd:PRK00553 160 RVLEllGKKDLVVVSPDYGGVKRARLIAEslELPLAIIDKRRPKHnvAESINVL--GEVKNKNCLIVDDMIDTGGTVIAA 237

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 818283614 234 REVLLHSGAKEVSAYATHGVFPKDSWKNFLP----NLFSHIWITDSCPDTikKISAEKEFEILSLAPSIAEII 302
Cdd:PRK00553 238 AKLLKKQKAKKVCVMATHGLFNKNAIQLFDEafkkKLIDKLFVSNSIPQT--KFEKKPQFKVVDLAHLYEEVL 308
PLN02369 PLN02369
ribose-phosphate pyrophosphokinase
 14-302 8.86e-26

ribose-phosphate pyrophosphokinase


Pssm-ID: 215209 [Multi-domain]  Cd Length: 302  Bit Score: 103.62  E-value: 8.86e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614  14 DLAKTIDDLMDAELGSISWEKFGDGwpELFINQADEIRNKDIVFVANFAKP--ETLFEQFAIIYSLPRHFVRSLRVIVLF 91
Cdd:PLN02369   2 ALSQEIACYLGLELGKITIKRFADG--EIYVQLQESVRGCDVFLVQPTCPPanENLMELLIMIDACRRASAKRITAVIPY 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614  92 YPVGTMERVDTYGDIATAETMARMisatpMTQTGPVIFSIFDIHALQGQFYFS---DKILPELVSAIPLLKERIKSiENL 168
Cdd:PLN02369  80 FGYARADRKTQGRESIAAKLVANL-----ITEAGADRVLACDLHSGQSMGYFDipvDHVYGQPVILDYLASKTISS-PDL 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614 169 AIAFPDDGAYKR---FGKMFPEYPHIICNKVR----MSDGEKIVtikeGAVEGKHVIIIDDLVQTGGTLLECREVLLHSG 241
Cdd:PLN02369 154 VVVSPDVGGVARaraFAKKLSDAPLAIVDKRRqghnVAEVMNLI----GDVKGKVAIMVDDMIDTAGTITKGAALLHQEG 229

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 818283614 242 AKEVSAYATHGVFPKDSWKNFLPNLFSHIWITDSCPDTIKKisAEKEFEILSLAPSIAEII 302
Cdd:PLN02369 230 AREVYACATHAVFSPPAIERLSSGLFQEVIVTNTIPVSEKN--YFPQLTVLSVANLLGETI 288
PRK02812 PRK02812
ribose-phosphate pyrophosphokinase; Provisional
 6-302 3.64e-23

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235072 [Multi-domain]  Cd Length: 330  Bit Score: 97.12  E-value: 3.64e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614   6 IFAHESVSDLAKTIDDLMDAELGSISWEKFGDGwpELFINQADEIRNKDIVFVANFAKP--ETLFEQFAIIYSLPRHFVR 83
Cdd:PRK02812  24 LFSGSSNPALAQEVARYLGMDLGPMIRKRFADG--ELYVQIQESIRGCDVYLIQPTCAPvnDHLMELLIMVDACRRASAR 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614  84 SLRVIVLFYPVGTMERVDTYGDIATAETMARMIsatpmTQTGPVIFSIFDIHALQGQFYFSdkILPELVSAIPLLKERIK 163
Cdd:PRK02812 102 QITAVIPYYGYARADRKTAGRESITAKLVANLI-----TKAGADRVLAMDLHSAQIQGYFD--IPCDHVYGSPVLLDYLA 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614 164 S--IENLAIAFPDDGAYKR---FGKMFPEYPHIICNKVRMSDGEKIVTIKEGAVEGKHVIIIDDLVQTGGTLLECREVLL 238
Cdd:PRK02812 175 SknLEDIVVVSPDVGGVARaraFAKKLNDAPLAIIDKRRQAHNVAEVLNVIGDVKGKTAILVDDMIDTGGTICEGARLLR 254

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 818283614 239 HSGAKEVSAYATHGVFPKDSWKNFLPNLFSHIWITDSCPdtikkISAEKEFE---ILSLAPSIAEII 302
Cdd:PRK02812 255 KEGAKQVYACATHAVFSPPAIERLSSGLFEEVIVTNTIP-----VPEERRFPqlkVLSVANMLGEAI 316
PRK02269 PRK02269
ribose-phosphate diphosphokinase;
6-303 1.88e-22

ribose-phosphate diphosphokinase;


Pssm-ID: 167353 [Multi-domain]  Cd Length: 320  Bit Score: 95.24  E-value: 1.88e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614   6 IFAHESVSDLAKTIDDLMDAELGSISWEKFGDGwpELFINQADEIRNKDIVFVANFAKP--ETLFEQFAIIYSLPRHFVR 83
Cdd:PRK02269   8 LFALSSNKELAEKVAQEIGIELGKSSVRQFSDG--EIQVNIEESIRGHHVFILQSTSSPvnDNLMEILIMVDALKRASAE 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614  84 SLRVIVLFYPVGTMERVDTYGDIATAETMARMISATPMTQtgpviFSIFDIHALQGQFYFSdkILPELVSAIPLL----K 159
Cdd:PRK02269  86 SINVVMPYYGYARQDRKARSREPITSKLVANMLEVAGVDR-----LLTVDLHAAQIQGFFD--IPVDHLMGAPLIadyfD 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614 160 ERIKSIENLAIAFPDDGAYKRFGKM--FPEYPHIICNKVRMSDGEKIVTIKE--GAVEGKHVIIIDDLVQTGGTLLECRE 235
Cdd:PRK02269 159 RRGLVGDDVVVVSPDHGGVTRARKLaqFLKTPIAIIDKRRSVDKMNTSEVMNiiGNVKGKKCILIDDMIDTAGTICHAAD 238

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 818283614 236 VLLHSGAKEVSAYATHGVFPKDSWKNFLPNLFSHIWITdscpDTIkKISAEKEF---EILSLAPSIAEIIK 303
Cdd:PRK02269 239 ALAEAGATEVYASCTHPVLSGPALDNIQKSAIEKLVVL----DTI-YLPEERLIdkiEQISIADLLGEAII 304
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
15-303 3.97e-20

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 88.47  E-value: 3.97e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614  15 LAKTIDDLMDAELGSISWEKFGDGwpELFINQADEIRNKDIVFVANFAKP--ETLFEQFAIIYSLPRHFVRSLRVIVLFY 92
Cdd:PRK03092   1 LAEEVAKELGVEVTPTTAYDFANG--EIYVRFEESVRGCDAFVLQSHTAPinKWLMEQLIMIDALKRASAKRITVVLPFY 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614  93 PVGtmeRVDTYG----DIAtaetmARMISATPMTQTGPVIFSIfDIHALQGQFYFsDKILPELvSAIPLLKERIKS---I 165
Cdd:PRK03092  79 PYA---RQDKKHrgrePIS-----ARLVADLFKTAGADRIMTV-DLHTAQIQGFF-DGPVDHL-FAMPLLADYVRDkydL 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614 166 ENLAIAFPDDGAYK-------RFGKMfpeyPHIICNKVRMSDGEKIVTIKE--GAVEGKHVIIIDDLVQTGGTLLECREV 236
Cdd:PRK03092 148 DNVTVVSPDAGRVRvaeqwadRLGGA----PLAFIHKTRDPTVPNQVVANRvvGDVEGRTCVLVDDMIDTGGTIAGAVRA 223

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 818283614 237 LLHSGAKEVSAYATHGVFpKDSWKNFLPNL-FSHIWITDSCPdtikkISAEKEFE---ILSLAPSIAEIIK 303
Cdd:PRK03092 224 LKEAGAKDVIIAATHGVL-SGPAAERLKNCgAREVVVTDTLP-----IPEEKRFDkltVLSIAPLLARAIR 288
PRK04923 PRK04923
ribose-phosphate diphosphokinase;
5-303 1.91e-18

ribose-phosphate diphosphokinase;


Pssm-ID: 179893 [Multi-domain]  Cd Length: 319  Bit Score: 83.82  E-value: 1.91e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614   5 IIFAHESVSDLAKTIDDLMDAELGSISWEKFGDGwpELFINQADEIRNKDIVFVANFAKP--ETLFEQFAIIYSLPRHFV 82
Cdd:PRK04923   8 LVFSGNANKPLAQSICKELGVRMGKALVTRFSDG--EVQVEIEESVRRQEVFVIQPTCAPsaENLMELLVLIDALKRASA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614  83 RSLRVIVLFYPVGTMERVDTYGDIA-TAETMARMISATPMTQTGPVifsifDIHALQGQFYFSDKIlpELVSAIPLLKE- 160
Cdd:PRK04923  86 ASVTAVIPYFGYSRQDRRMRSSRVPiTAKVAAKMISAMGADRVLTV-----DLHADQIQGFFDVPV--DNVYASPLLLAd 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614 161 --RIKSIENLAIAFPDDGAYKR---FGKMFPEYPHIICNKVRMSDGEKIVTIKEGAVEGKHVIIIDDLVQTGGTLLECRE 235
Cdd:PRK04923 159 iwRAYGTDNLIVVSPDVGGVVRaraVAKRLDDADLAIIDKRRPRANVATVMNIIGDVQGKTCVLVDDLVDTAGTLCAAAA 238

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 818283614 236 VLLHSGAKEVSAYATHGVFPKDSWKNFLPNLFSHIWITDSCPDTiKKISAEKEFEILSLAPSIAEIIK 303
Cdd:PRK04923 239 ALKQRGALKVVAYITHPVLSGPAVDNINNSQLDELVVTDTIPLS-EAARACAKIRQLSVAELLAETIR 305
PTZ00145 PTZ00145
phosphoribosylpyrophosphate synthetase; Provisional
 1-303 4.03e-17

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 240290 [Multi-domain]  Cd Length: 439  Bit Score: 81.07  E-value: 4.03e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614   1 MSKKIIFAHESVSDLAKTIDDLMDAELGSISWEKFGDGwpELFINQADEIRNKDIVFVANFAKP--ETLFEQFAIIYSLP 78
Cdd:PTZ00145 117 MENAILFSGSSNPLLSKNIADHLGTILGRVHLKRFADG--EVSMQFLESIRGKDVYIIQPTCPPvnENLIELLLMISTCR 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614  79 RHFVRSLRVIVLFYPVGTMERVDTYGDIATAETMARMISATPMTQTGPVifsifDIHALQGQFYFSDKILPELVSA--IP 156
Cdd:PTZ00145 195 RASAKKITAVIPYYGYARQDRKLSSRVPISAADVARMIEAMGVDRVVAI-----DLHSGQIQGFFGPRVPVDNLEAqlIG 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614 157 LLKERIKSIENLAIAFPDDGAYKRFGKMFPEYPH----------IICNKVRMSDGEKIVTIkeGAVEGKHVIIIDDLVQT 226
Cdd:PTZ00145 270 LDYFTKKDLYKPVIVSPDAGGVYRARKFQDGLNHrgisdcgiamLIKQRTKPNEIEKMDLV--GNVYDSDVIIVDDMIDT 347

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 818283614 227 GGTLLECREVLLHSGAKEVSAYATHGVFPKDSWKNFLPNLFSHIWITDSCPDTiKKISAEKEFEILSLAPSIAEIIK 303
Cdd:PTZ00145 348 SGTLCEAAKQLKKHGARRVFAFATHGLFSGPAIERIEASPLEEVVVTDTVKSN-KNIDSCKKITKLSVSVLVADAIR 423
PRK02458 PRK02458
ribose-phosphate pyrophosphokinase; Provisional
 6-285 3.28e-16

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235039 [Multi-domain]  Cd Length: 323  Bit Score: 77.47  E-value: 3.28e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614   6 IFAHESVSDLAKTIDDLMDAELGSISWEKFGDGwpELFINQADEIRNKDIVFVANFAKP--ETLFEQFAIIYSLPRHFVR 83
Cdd:PRK02458  12 LFSLNSNLEIAEKIAQAAGVPLGKLSSRQFSDG--EIMINIEESVRGDDIYIIQSTSFPvnDHLWELLIMIDACKRASAN 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614  84 SLRVIVLFYPVGTMERVDTYGDIATAETMARMIsatpmTQTGPVIFSIFDIHALQGQFYFSdkILPELVSAIPLLKERIK 163
Cdd:PRK02458  90 TVNVVLPYFGYARQDRIAKPREPITAKLVANML-----VKAGVDRVLTLDLHAVQVQGFFD--IPVDNLFTVPLFAKHYC 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614 164 SI----ENLAIAFPDDGAYKRfGKMFPEYphiICNKVRMSDGEKIVTIKE-----GAVEGKHVIIIDDLVQTGGTLLECR 234
Cdd:PRK02458 163 KKglsgSDVVVVSPKNSGIKR-ARSLAEY---LDAPIAIIDYAQDDSEREegyiiGDVAGKKAILIDDILNTGKTFAEAA 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 818283614 235 EVLLHSGAKEVSAYATHGVFPKDSWKNFLPNLFSHIWITDSC------PDTIKKISA 285
Cdd:PRK02458 239 KIVEREGATEIYAVASHGLFAGGAAEVLENAPIKEILVTDSVatkervPKNVTYLSA 295
PRK07199 PRK07199
ribose-phosphate diphosphokinase;
2-304 3.97e-16

ribose-phosphate diphosphokinase;


Pssm-ID: 235960 [Multi-domain]  Cd Length: 301  Bit Score: 76.90  E-value: 3.97e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614   2 SKKIIFAHESVSDLAKTIDDLMDAELGSISWEKFGDGwpELFINQADEIRNKDIVFVANFAKPEtlfEQFaiiysLPRHF 81
Cdd:PRK07199   1 MQPLLLALPGNEAAAGRLAAALGVEVGRIELHRFPDG--ESYVRLDSPVAGRTVVLVCSLDRPD---EKL-----LPLLF 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614  82 V----RSL--RVIVLFYPVGTMERVDTY---GDIATAETMARMISATpmtqtgpvifsiFD-----------IHALQGQF 141
Cdd:PRK07199  71 AaeaaRELgaRRVGLVAPYLAYMRQDIAfhpGEAISQRHFARLLSGS------------FDrlvtvdphlhrYPSLSEVY 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614 142 yfsdKILPELVSAIPLLKERIKS-IENLAIAFPD-------DGAYKRFGkmfpeYPHIICNKVRMSDGEKIVTIKEGAV- 212
Cdd:PRK07199 139 ----PIPAVVLSAAPAIAAWIRAhVPRPLLIGPDeeseqwvAAVAERAG-----APHAVLRKTRHGDRDVEISLPDAAPw 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614 213 EGKHVIIIDDLVQTGGTLLECREVLLHSGAKEVSAYATHGVFPKDSWKNFLPNLFSHIWITDSCPDTIKKIsaekefeil 292
Cdd:PRK07199 210 AGRTPVLVDDIVSTGRTLIEAARQLRAAGAASPDCVVVHALFAGDAYSALAAAGIARVVSTDTVPHPSNAI--------- 280

                        330
                 ....*....|..
gi 818283614 293 SLAPSIAEIIKD 304
Cdd:PRK07199 281 SLAPLLAEALRR 292
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 154-265 5.11e-14

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 67.81  E-value: 5.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614 154 AIPLLKERIKS--IENLAIAFPDDGAYKRFGKMFPEY--PHIICNKVRMSDGEKIVT------IKEGAVEGKHVIIIDDL 223
Cdd:cd06223    1 AGRLLAEEIREdlLEPDVVVGILRGGLPLAAALARALglPLAFIRKERKGPGRTPSEpyglelPLGGDVKGKRVLLVDDV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 818283614 224 VQTGGTLLECREVLLHSGAKEVSAYATHGVFPKDSWKNFLPN 265
Cdd:cd06223   81 IATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGARELASPG 122
ComFC COG1040
DNA utilization protein ComFC/GntX, contains phosphoribosyltransferase domain [General ...
 208-249 3.04e-09

DNA utilization protein ComFC/GntX, contains phosphoribosyltransferase domain [General function prediction only];


Pssm-ID: 440662 [Multi-domain]  Cd Length: 196  Bit Score: 55.60  E-value: 3.04e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 818283614 208 KEGAVEGKHVIIIDDLVQTGGTLLECREVLLHSGAKEVSAYA 249
Cdd:COG1040  149 PPARLAGKHVLLVDDVLTTGATLAEAARALKAAGAARVDVLV 190
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 5-118 9.34e-09

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 52.42  E-value: 9.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614    5 IIFAHESVSDLAKTIDDLMDAELGSISWEKFGDGwpELFINQADEIRNKDIVFVANFAKP--ETLFEQFAIIYSLPRHFV 82
Cdd:pfam13793   2 KIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDG--EIYVRIEESVRGKDVFIIQSTCPPvnDNLMELLIMIDALKRASA 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 818283614   83 RSLRVIVLFYPVGTMERVDTYGDIATAETMARMISA 118
Cdd:pfam13793  80 KRITAVIPYFGYARQDRKDKPREPITAKLVADLLEA 115
PRK06827 PRK06827
phosphoribosylpyrophosphate synthetase; Provisional
 136-254 1.12e-05

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 180714 [Multi-domain]  Cd Length: 382  Bit Score: 46.48  E-value: 1.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614 136 ALQGQFYFS---DKIL------PELVSAIPL---------------LKERIKSI----ENLAIAFPDDGAYKR------- 180
Cdd:PRK06827 149 ALALQELEElgvDNIItfdahdPRIENAIPLmgfenlypsyqiikaLLKNEKDLeidkDHLMVISPDTGAMDRakyyasv 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614 181 FGK---MF---PEYPHIICNKvrmsdgEKIVTIK--EGAVEGKHVIIIDDLVQTGGTLLECREVLLHSGAKEVSAYATHG 252
Cdd:PRK06827 229 LGVdlgLFykrRDYSRVVNGR------NPIVAHEflGRDVEGKDVLIVDDMIASGGSMIDAAKELKSRGAKKIIVAATFG 302


                 ..
gi 818283614 253 VF 254
Cdd:PRK06827 303 FF 304
HptA COG0634
Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; ...
 212-245 1.15e-05

Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; Hypoxanthine-guanine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440399  Cd Length: 176  Bit Score: 45.02  E-value: 1.15e-05
                         10        20        30
                 ....*....|....*....|....*....|....
gi 818283614 212 VEGKHVIIIDDLVQTGGTLLECREVLLHSGAKEV 245
Cdd:COG0634   89 IEGRDVLIVEDIIDTGLTLSYLLELLKSRGPASV 122
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 210-303 1.69e-05

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


Pssm-ID: 434046  Cd Length: 184  Bit Score: 44.42  E-value: 1.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818283614  210 GAVEGKHVIIIDDLVQTGGTLLECREVLLHSGAKEVSAYATHGVFPKDSWKNFLPNLFSHIWITDSCPDTIKKISAEKeF 289
Cdd:pfam14572  79 GDVGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHK-I 157

                          90
                  ....*....|....
gi 818283614  290 EILSLAPSIAEIIK 303
Cdd:pfam14572 158 KTIDISQLIAEAIR 171
PRK11595 PRK11595
DNA utilization protein GntX; Provisional
 209-249 2.19e-05

DNA utilization protein GntX; Provisional


Pssm-ID: 183221 [Multi-domain]  Cd Length: 227  Bit Score: 44.64  E-value: 2.19e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 818283614 209 EGAVEGKHVIIIDDLVQTGGTLLECREVLLHSGAKEVSAYA 249
Cdd:PRK11595 182 ELPVQGQHMAIVDDVVTTGSTVAEIAQLLLRNGAASVQVWC 222
PRK07322 PRK07322
adenine phosphoribosyltransferase; Provisional
 211-249 2.44e-05

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 180928  Cd Length: 178  Bit Score: 44.20  E-value: 2.44e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 818283614 211 AVEGKHVIIIDDLVQTGGTLLECREVLLHSGAkEVSAYA 249
Cdd:PRK07322 117 KLKGKRVAIVDDVVSTGGTLTALERLVERAGG-QVVAKA 154
PLN02238 PLN02238
hypoxanthine phosphoribosyltransferase
 199-246 2.91e-04

hypoxanthine phosphoribosyltransferase


Pssm-ID: 215132  Cd Length: 189  Bit Score: 41.18  E-value: 2.91e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 818283614 199 SDGEKIVTI--KEGAVEGKHVIIIDDLVQTGGTLLECREVLLHSGAKEVS 246
Cdd:PLN02238  80 SSGVAKVSGadLKIDVKGKHVLLVEDIVDTGNTLSALVAHLEAKGAASVS 129
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 201-245 9.33e-04

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 38.89  E-value: 9.33e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 818283614  201 GEKIVTIKEGAVEGKHVIIIDDLVQTGGTLLECREVLLHSGAKEV 245
Cdd:pfam00156  69 EVMKTSSALPDLKGKTVLIVDDILDTGGTLLKVLELLKNVGPKEV 113
PRK09162 PRK09162
hypoxanthine-guanine phosphoribosyltransferase; Provisional
 211-247 2.07e-03

hypoxanthine-guanine phosphoribosyltransferase; Provisional


Pssm-ID: 181675  Cd Length: 181  Bit Score: 38.30  E-value: 2.07e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 818283614 211 AVEGKHVIIIDDLVQTGGTLLECREVLLHSGAKEVSA 247
Cdd:PRK09162  94 SLKGRTVLVVDDILDEGHTLAAIRDRCLEMGAAEVYS 130
PRK02277 PRK02277
orotate phosphoribosyltransferase-like protein; Provisional
 210-245 4.48e-03

orotate phosphoribosyltransferase-like protein; Provisional


Pssm-ID: 235023 [Multi-domain]  Cd Length: 200  Bit Score: 37.54  E-value: 4.48e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 818283614 210 GAVEGKHVIIIDDLVQTGGTLLECREVLLHSGAKEV 245
Cdd:PRK02277 136 ASVEGKRCVIVDDVITSGTTMKETIEYLKEHGGKPV 171
PRK05793 PRK05793
amidophosphoribosyltransferase; Provisional
 202-245 4.75e-03

amidophosphoribosyltransferase; Provisional


Pssm-ID: 235611 [Multi-domain]  Cd Length: 469  Bit Score: 38.48  E-value: 4.75e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 818283614 202 EKIVTIK----EGAVEGKHVIIIDDLVQTGGTLLECREVLLHSGAKEV 245
Cdd:PRK05793 337 ERAVRVKlnplKVNVEGKRVVLIDDSIVRGTTSKRLVELLRKAGAKEV 384
PLN02293 PLN02293
adenine phosphoribosyltransferase
 210-245 8.51e-03

adenine phosphoribosyltransferase


Pssm-ID: 177930  Cd Length: 187  Bit Score: 36.58  E-value: 8.51e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 818283614 210 GAVE-GKHVIIIDDLVQTGGTLLECREVLLHSGAKEV 245
Cdd:PLN02293 120 GAVEpGERALVIDDLIATGGTLCAAINLLERAGAEVV 156
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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