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Conserved domains on  [gi|767126616|gb|KJG45555|]
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hypothetical protein UA30_19615 [Photobacterium angustum]

Protein Classification

type II secretion system protein( domain architecture ID 11450365)

type II secretion system protein similar to Pseudomonas aeruginosa type II secretion system protein H, which is involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins; required for the translocation of a variety of enzymes across the outer membrane; pilin similar to fimbrial protein PilE, which is required for pilus biogenesis, as well as fimbrial protein PilA, which is responsible for the adhesive property of the pilus

Gene Ontology:  GO:0005886|GO:0015628|GO:0015627
PubMed:  30767847|1365398

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PulG COG2165
Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, ...
 1-62 9.52e-12

Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


:

Pssm-ID: 441768 [Multi-domain]  Cd Length: 99  Bit Score: 58.77  E-value: 9.52e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767126616   1 MDRYGAIARQsKGFSLIELVIVIVILGILAVTVAPRFLSISSDATKASLKGIAGSLHTVIDL 62
Cdd:COG2165    1 MKLRRRRRRQ-RGFTLIELLVVIAIIGILAALALPALQGARERARRAELRSNLRQIQQALER 61
 
Name Accession Description Interval E-value
PulG COG2165
Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, ...
 1-62 9.52e-12

Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 441768 [Multi-domain]  Cd Length: 99  Bit Score: 58.77  E-value: 9.52e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767126616   1 MDRYGAIARQsKGFSLIELVIVIVILGILAVTVAPRFLSISSDATKASLKGIAGSLHTVIDL 62
Cdd:COG2165    1 MKLRRRRRRQ-RGFTLIELLVVIAIIGILAALALPALQGARERARRAELRSNLRQIQQALER 61
typeII_sec_gspG TIGR01710
type II secretion system protein G; This model represents GspG, protein G of the main terminal ...
 12-71 4.33e-08

type II secretion system protein G; This model represents GspG, protein G of the main terminal branch of the general secretion pathway, also called type II secretion. It transports folded proteins across the bacterial outer membrane and is widely distributed in Gram-negative pathogens. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 130771 [Multi-domain]  Cd Length: 134  Bit Score: 50.12  E-value: 4.33e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767126616   12 KGFSLIELVIVIVILGILAVTVAPRFLSISSDA----TKASLKGIAGSLHTV-IDLVEYKAIMQG 71
Cdd:TIGR01710   1 RGFTLLEIMVVLVILGLLAALVAPKLFSQADKAkaqvAKAQIKALKNALDMYrLDNGRYPTEEQG 65
N_methyl pfam07963
Prokaryotic N-terminal methylation motif; This short motif directs methylation of the ...
 9-34 8.82e-06

Prokaryotic N-terminal methylation motif; This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see pfam00114, pfam05946, pfam02501 and pfam07596.


Pssm-ID: 429756 [Multi-domain]  Cd Length: 27  Bit Score: 40.82  E-value: 8.82e-06
                          10        20
                  ....*....|....*....|....*.
gi 767126616    9 RQSKGFSLIELVIVIVILGILAVTVA 34
Cdd:pfam07963   2 RKQRGFTLIELLVALAILAILLAAAL 27
PRK10506 PRK10506
prepilin peptidase-dependent protein;
9-32 3.31e-03

prepilin peptidase-dependent protein;


Pssm-ID: 236704 [Multi-domain]  Cd Length: 162  Bit Score: 36.51  E-value: 3.31e-03
                         10        20
                 ....*....|....*....|....
gi 767126616   9 RQSKGFSLIELVIVIVILGILAVT 32
Cdd:PRK10506   6 KKQRGYTLIELLVVMTIVSILSAW 29
 
Name Accession Description Interval E-value
PulG COG2165
Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, ...
 1-62 9.52e-12

Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 441768 [Multi-domain]  Cd Length: 99  Bit Score: 58.77  E-value: 9.52e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767126616   1 MDRYGAIARQsKGFSLIELVIVIVILGILAVTVAPRFLSISSDATKASLKGIAGSLHTVIDL 62
Cdd:COG2165    1 MKLRRRRRRQ-RGFTLIELLVVIAIIGILAALALPALQGARERARRAELRSNLRQIQQALER 61
FimT COG4970
Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];
6-72 2.26e-10

Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];


Pssm-ID: 443996 [Multi-domain]  Cd Length: 73  Bit Score: 54.47  E-value: 2.26e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767126616   6 AIARQSKGFSLIELVIVIVILGILAVTVAPRFLSISSdatKASLKGIAGSLHTVIDLVEYKAIMQGK 72
Cdd:COG4970    3 RLRRRQRGFTLIELLVVLAILAILAAIAVPSFSSLIA---RQRLRAAANELAAALRLARSEAIRRGQ 66
typeII_sec_gspG TIGR01710
type II secretion system protein G; This model represents GspG, protein G of the main terminal ...
 12-71 4.33e-08

type II secretion system protein G; This model represents GspG, protein G of the main terminal branch of the general secretion pathway, also called type II secretion. It transports folded proteins across the bacterial outer membrane and is widely distributed in Gram-negative pathogens. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 130771 [Multi-domain]  Cd Length: 134  Bit Score: 50.12  E-value: 4.33e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767126616   12 KGFSLIELVIVIVILGILAVTVAPRFLSISSDA----TKASLKGIAGSLHTV-IDLVEYKAIMQG 71
Cdd:TIGR01710   1 RGFTLLEIMVVLVILGLLAALVAPKLFSQADKAkaqvAKAQIKALKNALDMYrLDNGRYPTEEQG 65
PilE COG4968
Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];
9-39 7.13e-07

Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];


Pssm-ID: 443994 [Multi-domain]  Cd Length: 124  Bit Score: 46.22  E-value: 7.13e-07
                         10        20        30
                 ....*....|....*....|....*....|.
gi 767126616   9 RQSKGFSLIELVIVIVILGILAVTVAPRFLS 39
Cdd:COG4968    7 RRQRGFTLIELMIVVAIIGILAAIAIPSYQD 37
ComGC COG4537
Competence protein ComGC [Mobilome: prophages, transposons];
1-44 4.48e-06

Competence protein ComGC [Mobilome: prophages, transposons];


Pssm-ID: 443603 [Multi-domain]  Cd Length: 108  Bit Score: 43.76  E-value: 4.48e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 767126616   1 MDRYGAIARQSKGFSLIELVIVIVILGILAVTVAPRFLSISSDA 44
Cdd:COG4537    1 MKKKKRKLKKEKGFTLIEMLIVLLIISILLLIAVPNLTKQRETA 44
N_methyl pfam07963
Prokaryotic N-terminal methylation motif; This short motif directs methylation of the ...
 9-34 8.82e-06

Prokaryotic N-terminal methylation motif; This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see pfam00114, pfam05946, pfam02501 and pfam07596.


Pssm-ID: 429756 [Multi-domain]  Cd Length: 27  Bit Score: 40.82  E-value: 8.82e-06
                          10        20
                  ....*....|....*....|....*.
gi 767126616    9 RQSKGFSLIELVIVIVILGILAVTVA 34
Cdd:pfam07963   2 RKQRGFTLIELLVALAILAILLAAAL 27
PilA COG4969
Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];
12-30 1.17e-05

Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];


Pssm-ID: 443995 [Multi-domain]  Cd Length: 134  Bit Score: 43.16  E-value: 1.17e-05
                         10
                 ....*....|....*....
gi 767126616  12 KGFSLIELVIVIVILGILA 30
Cdd:COG4969    6 KGFTLIELMIVVAIIGILA 24
IV_pilin_GFxxxE TIGR02532
prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all ...
 12-34 8.78e-05

prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all examples of the N-terminal region of bacterial proteins that resemble type IV pilins at their N-terminus, with a cleavage site G^FxxxE followed by a hydrophobic stretch. The new N-terminal residue, usually Phe, is methylated. Separate domains of the prepilin peptidase appear responsible for cleavage and methylation. Proteins with this N-terminal region include type IV pilins and other components of pilus biogenesis, competence proteins, and type II secretion proteins. Typically several proteins in a single operon have this N-terminal domain. The N-terminal cleavage and methylation site is described by PROSITE motif PS00409 as [KRHEQSTAG]-G-[FYLIVM]-[ST]-[LT]-[LIVP]-E-[LIVMFWSTAG](14). [Cell envelope, Surface structures, Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274182 [Multi-domain]  Cd Length: 24  Bit Score: 38.05  E-value: 8.78e-05
                          10        20
                  ....*....|....*....|...
gi 767126616   12 KGFSLIELVIVIVILGILAVTVA 34
Cdd:TIGR02532   2 RGFTLIELLVVLAILGILALIAL 24
PulJ COG4795
Type II secretory pathway, PulJ/GspJ component [Intracellular trafficking, secretion, and ...
 9-48 1.66e-04

Type II secretory pathway, PulJ/GspJ component [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 443823 [Multi-domain]  Cd Length: 118  Bit Score: 39.61  E-value: 1.66e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 767126616   9 RQSKGFSLIELVIVIVILGILAVTVApRFLSISSDATKAS 48
Cdd:COG4795    6 RRQRGFTLLELLVALAIFALLLLAAY-RGLDSVLRSRERL 44
typeII_sec_gspH TIGR01708
type II secretion system protein H; This model represents GspH, protein H of the main terminal ...
 9-72 4.76e-04

type II secretion system protein H; This model represents GspH, protein H of the main terminal branch of the general secretion pathway, also called type II secretion. It transports folded proteins across the bacterial outer membrane and is widely distributed in Gram-negative pathogens. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 130769 [Multi-domain]  Cd Length: 143  Bit Score: 38.70  E-value: 4.76e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767126616    9 RQSkGFSLIELVIVIVILGILAVTVAPrflSISSDATKASLKGIAGSLHTVIDLVEYKAIMQGK 72
Cdd:TIGR01708   2 RQS-GFTLIELLVVLAIMGLVAAAAAL---SLVSHYGTKSLDQVAGRLAARLRLAQTSARATGR 61
PRK10506 PRK10506
prepilin peptidase-dependent protein;
9-32 3.31e-03

prepilin peptidase-dependent protein;


Pssm-ID: 236704 [Multi-domain]  Cd Length: 162  Bit Score: 36.51  E-value: 3.31e-03
                         10        20
                 ....*....|....*....|....
gi 767126616   9 RQSKGFSLIELVIVIVILGILAVT 32
Cdd:PRK10506   6 KKQRGYTLIELLVVMTIVSILSAW 29
PilW COG4966
Type IV pilus assembly protein PilW [Cell motility, Extracellular structures];
9-42 4.57e-03

Type IV pilus assembly protein PilW [Cell motility, Extracellular structures];


Pssm-ID: 443992 [Multi-domain]  Cd Length: 158  Bit Score: 36.31  E-value: 4.57e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 767126616   9 RQSKGFSLIELVIVIVILGILAVTVAPRFLSISS 42
Cdd:COG4966    2 RRQRGFTLVELMVALAIGLIVLAAVLQLFLSSRR 35
PilV COG4967
Type IV pilus assembly protein PilV [Cell motility, Extracellular structures];
3-34 6.98e-03

Type IV pilus assembly protein PilV [Cell motility, Extracellular structures];


Pssm-ID: 443993 [Multi-domain]  Cd Length: 86  Bit Score: 34.57  E-value: 6.98e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 767126616   3 RYGAIARQSKGFSLIELVIVIVILGILAVTVA 34
Cdd:COG4967    2 SRRRRRRRQRGFTLIEVLVALVILSIGLLGLA 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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