|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0121 |
TIGR00900 |
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds] |
10-367 |
4.07e-79 |
|
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 249.16 E-value: 4.07e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 10 YRHLFMAQVIALIGTGLATVALGLlaYDLAGDRAGAVLGTALAIKMSAYILVAPVAAAFADKFPRRTMLVTLDLVRALVA 89
Cdd:TIGR00900 1 FRLLFAAQLISLIGTAITQVALPL--YVLAGTGSASVLSLAALAGMLPYVVLSPIAGALADRYDRKKVMIGADLIRAVLV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 90 ITLPFVT-----QIWEIYILIFILQAASAAFTPTFQATIPDILPDErEYTRALSLSRLAYDLESVISPMLAAALLTVMSF 164
Cdd:TIGR00900 79 AVLPFVAllgglNIWQVYVLAGILAIAQAFFTPAYQAMLPDLVPEE-QLTQANSLSQAVRSLFYIVGPGIGGLMYATLGI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 165 HNLFAGTAVGFLASAALVVSVTLPKMKALTVK---RSIYDKTTRGMRIFLKTPRLRGLLALNMAVAAASAMVIVNTVVLV 241
Cdd:TIGR00900 158 KWAIWVDAVGFAISALLIVSVRIPELAASEIQalsNAVLRDTREGIKFVLKNPLLRTLLLLALLFNLVFAPAIVALFPYV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 242 QAD-FGFSQRSTAIALAFFGVGSMVSALVLPrLLDNMSDRMPMLAGtALLVIGL---GSGIFLKDYITLVVLWALLGVGY 317
Cdd:TIGR00900 238 QSKyLGRGSTHYGWVLAAFGLGALLGALLLG-LLGRYFKRMALMTG-AIFVIGLailVVGLTPPNFPLFLVLWFAIGVGY 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 636246597 318 SLSQTPGGRLLRRSSTAEDRPALFAAQFALSHSCWLVTYPLAGWVGAAWG 367
Cdd:TIGR00900 316 GPINVPQGTLLQRRVPAELLGRVFGAQFSLSHAAWPLGLILAGPLADHLG 365
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
10-391 |
1.44e-55 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 188.59 E-value: 1.44e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 10 YRHLFMAQVIALIGTGLATVALGLLAYDLAGDraGAVLGTALAIKMSAYILVAPVAAAFADKFPRRTMLVTLDLVRALVA 89
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGS--ALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 90 ITLPFVT-----QIWEIYILIFILQAASAAFTPTFQATIPDILPDErEYTRALSLSRLAYDLESVISPMLAAALLTVMSF 164
Cdd:cd06173 79 AVLALLAllgslSLWLLLVLAFLLGIASAFFGPARQALLPELVPKE-QLVRANALNSLATQLARIIGPALGGLLVALLGP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 165 HNLFAGTAVGFLASAALVVSVTLPKMKALTVKRSIY-DKTTRGMRIFLKTPRLRGLLALNMAVAAASAMVIVNTVVLVQA 243
Cdd:cd06173 158 GGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLlRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 244 DFGFSQRSTAIALAFFGVGSMVSALVLPRLLDNMSDRMPMLAGTALLVIGLGSGIFLKDYITLVVLWALLGVGYSLSQTP 323
Cdd:cd06173 238 VLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVP 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 636246597 324 GGRLLRRSSTAEDRPALFAAQFALSHSCWLVTYPLAGWVGAAWGTQASFIALtvvATLSLVTAVLIWR 391
Cdd:cd06173 318 LNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLA---GALLLLAALLLLL 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
13-347 |
7.49e-30 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 118.54 E-value: 7.49e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 13 LFMAQVIALIGTGLATVALGLLAYDLAGDRAgaVLGTALAIKMSAYILVAPVAAAFADKFPRRTMLVTLDLVRALVAITL 92
Cdd:COG2814 15 LALGAFLSGLGIGIVLPALPLIAADLGASPA--QAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 93 PFVTQIWEIYILIFILQAASAAFTPTFQATIPDILPDEReYTRALSLSRLAYDLESVISPMLAAALLTVMSFHNLFAGTA 172
Cdd:COG2814 93 ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPER-RGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 173 VGFLAsAALVVSVTLPKMKALTVKRSIydkttRGMRIFLKTPRLRGLLALNMAVAAASAMVIVNTVVLVQADFGFSQRST 252
Cdd:COG2814 172 VLALL-ALLLLLRLLPESRPAARARLR-----GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 253 AIALAFFGVGSMVSALVLPRLLDNMSDRMPMLAGTALLVIGLGSGIFLKDYITLVVLWALLGVGYSLSQTPGGRLLRRSS 332
Cdd:COG2814 246 GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELA 325
|
330
....*....|....*
gi 636246597 333 TAEDRPALFAAQFAL 347
Cdd:COG2814 326 PPEARGRASGLYNSA 340
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
13-389 |
2.38e-25 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 106.51 E-value: 2.38e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 13 LFMAQVIALIGTGLATVALGLLAYDLAGDraGAVLGTALAIKMSAYILVAPVAAAFADKFPRRTMLVTLDLVRALVAITL 92
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGAS--VAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 93 PFVTQIWEIYILIFILQAASAAFTPTFQATIPDILPDEREyTRALSLSRLAYDLESVISPMLAAALLTVMSFHNLFAGTA 172
Cdd:cd17325 79 AFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEER-GRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 173 VGFLASAALVVSVTLPKMKALTVKRSIYDKTTRGMRIFLKTPRLRGLLALNMAVAAASAMVIVNTVVLVQADFGFSQRST 252
Cdd:cd17325 158 ALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 253 AIALAFFGVGSMVSALVLPRLLDNMSDRMPMLAGTALLVIGLGSGIFLKDYITLVVLWALLGVGYSLSQTPGGRLLRRSS 332
Cdd:cd17325 238 GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIV 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 636246597 333 TAEDRPALFAAQFALSHSCWLVTYPLAGWVGAAWGTQASFIALTVVATLSLVTAVLI 389
Cdd:cd17325 318 PPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
13-354 |
4.38e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 93.64 E-value: 4.38e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 13 LFMAQVIALIGTGLATVALGL-LAYDLAGDRAgaVLGTALAIKMSAYILVAPVAAAFADKFPRRTMLVTLDLVRALVAIT 91
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPT--EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 92 LPFVTQIWEIYILIFILQAASAAFTPTFQATIPDILPdEREYTRALSLSRLAYDLESVISPMLAAALLTVMSFHNLFAGT 171
Cdd:pfam07690 79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFP-PEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 172 A-VGFLASAALVVSVTLPKMKALTVKRSIYDKTTRGMRIFLKTPRLRGLLALnmAVAAASAMVIVNTVVLVQADFGFSQR 250
Cdd:pfam07690 158 AiLSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLAL--LLFGFAFFGLLTYLPLYQEVLGLSAL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 251 STAIALAFFGVGSMVSALVLPRLLDNMSDRMPMLAGTALLVIGLGSGIFL---KDYITLVVLWALLGVGYSLSQTPGGRL 327
Cdd:pfam07690 236 LAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLsltLSSLWLLLALLLLGFGFGLVFPALNAL 315
|
330 340
....*....|....*....|....*..
gi 636246597 328 LRRSSTAEDRPALFAAQFALSHSCWLV 354
Cdd:pfam07690 316 VSDLAPKEERGTASGLYNTAGSLGGAL 342
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
13-387 |
3.23e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 88.64 E-value: 3.23e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 13 LFMAQVIALIGTGLATVALGLLAYDLAGDRAgaVLGTALAIKMSAYILVAPVAAAFADKFPRRTMLVTLDLVRALVAITL 92
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSAS--QLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 93 PFVTQIWEIYILIFILQAASAAFTPTFQATIPDILPdEREYTRALSLSRLAYDLESVISPMLAAALLT--VMSFHNLFAG 170
Cdd:cd06174 79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFP-ERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 171 TAVGFLASAALV--VSVTLPKMKALTVKRSIYDKTTRGMRIFLKTPRLRGLLALNMAVAAASAMVIVNTVVLVQADFGFS 248
Cdd:cd06174 158 AAALALLAAILLllVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 249 QRSTAIALAFFGVGSMVSALVLPRLLDNMSDRMP-MLAGTALLVIGLGSGIFLKDYITLVVLWALLGVGYSLSQTPGGRL 327
Cdd:cd06174 238 VAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPlLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFAL 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 636246597 328 LRRSSTAEDRPALFAAQFALSHSCWLVTYPLAGWVGAA-WGTQASFIALTVVATLSLVTAV 387
Cdd:cd06174 318 IAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtFGLTGAFLVLAVLLLLAAILLL 378
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
6-392 |
3.74e-16 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 79.51 E-value: 3.74e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 6 SNRTYRHLFMAQVIALIGTGLATVALGLL------AYDLAGDRAGAVLgTALAIkmsAYILVAPVAAAFADKFPRRTMLV 79
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATALWGPLipalkdAFGLSDAQAGLLL-FAFFL---GYLLASLPAGRLIDRFGYKRGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 80 TLDLVRALVAITLPFVTQIWEIYILIFILQAASAAFTPTFQATIPDILPDEReyTRALSLSRLAYDLESVISPMLAAALL 159
Cdd:COG0738 78 LGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETA--ASRLNLLHAFFSLGALLGPLLGGLLI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 160 TV---MSFHNLFAGTAVGFLASAALVVSVTLPKMKALTVKRSIYDKTTRGMrifLKTPRLRGLLALNMAVAAASAMVIVN 236
Cdd:COG0738 156 LLglsLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSL---LKNPRLLLGGLAIFLYVGAEGAIGDW 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 237 TVVLVQADFGFSQRSTAIALAFFGVGSMVSALVLPRLLDNMSDRMPMLAGTALLVIGLGSGIFLKDYITLVVLWALLGVG 316
Cdd:COG0738 233 LPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLG 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 636246597 317 YSLsQTPGGRLLRRSSTAEDRPALFAAQFALSHSCWLVTYPLAGWVGAAWGTQASFIALTVVATLSLVTAVLIWRP 392
Cdd:COG0738 313 LSL-MFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRK 387
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
13-316 |
8.39e-16 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 78.42 E-value: 8.39e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 13 LFMAQVIALIGTGLATVALGLLAYDLAGDRAGAVlGTALAIKMSAYILVAPVAAAFADKFPRRTMLVTLDLVRALVAITL 92
Cdd:cd17329 4 LLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIV-GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 93 PFVTQIWEIYILIFILQAASAAFTPTFQATIPDILPDEReYTRALSLSRLAYDLESVISPMLaAALLTVMSFHNLFAGTA 172
Cdd:cd17329 83 GFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPEN-RTRAFSLLYWAINLGVAIGPLL-GGLLLLYSFRLLFLAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 173 VGFLasAALVVSVTLPKMKALTVKRSIYDKTTRGMRIFLKTPRLRGLLALNMAVAAASAMVIVNTVVLVQADFGFSQRST 252
Cdd:cd17329 161 VLFL--LAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLL 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 636246597 253 AIALAFFGVGSMVSALVLPRLLDNMSDRMPMLAGTALLVIGLGSGIFLKDYITLVVLWALLGVG 316
Cdd:cd17329 239 GLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLG 302
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
13-395 |
2.38e-15 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 76.83 E-value: 2.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 13 LFMAQVIALIGTGLATVALGLLAYDLAGDRAgaVLGTALAIKMSAYILVAPVAAAFADKFPRRTMLVTLDLVRALVAITL 92
Cdd:COG2271 15 LFLAYFLNYLDRSNLSVAAPPLQADLGLSAA--QLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 93 PFVTQIWEIYILIFILQAASAAFTPTFQATIPDILPdEREYTRALSLSRLAYDLESVISPMLAAALLTVMSFHNLFAGTA 172
Cdd:COG2271 93 GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFP-PKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 173 VGFLASAALvvsvtlpkmkaltvkrsiydkttrgmriflktpRLRGLLALNMAVAAASAMVIVNTVVLVQADFGFSQRST 252
Cdd:COG2271 172 LPGLLLALL---------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQA 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 253 AIALAFFGVGSMVSALVLPRLLDNMSDR--MPMLAGTALLVIGLGSGIFLKDYITLVVLWALLGVGYSLSQTPGGRLLRR 330
Cdd:COG2271 219 GLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAE 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 636246597 331 SSTAEDRPALFAAQFALSHSCWLVTYPLAGWVGAAWGTQASFIALTVVATLSLVTAVLIWRPEHE 395
Cdd:COG2271 299 LFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
57-390 |
1.69e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 74.51 E-value: 1.69e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 57 AYILVAPVAAAFADKFPRRTMLVTLDLVRALVAITLPFVTQIWEIYILIFILQAASAAFTPTFQATIPDILPDEREyTRA 136
Cdd:cd17324 46 GYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKR-GRA 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 137 LSLSRLAYDLESVISPMLAAALLTVMSFHNLFAGTAVgFLASAALVVSVTLPKMKALTVKRSiydKTTRGMRIFLKTPRL 216
Cdd:cd17324 125 IGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAV-LALLAALLLWRLLPSLPPKKPGSL---GLLSSLLLLLRNPRL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 217 RGLLALNMAVAAASAMVIVNTVVLVQADFGFSQRSTAIALAFFGVGSMVSALVLPRLLDNMSDRMPMLAGTALLVIGLGS 296
Cdd:cd17324 201 RLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLL 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 297 GIFLKDYITLVVLWALLGVGYSLSQTPG-GRLLRRSSTAEDRPAlfaaqfALSHSCWLVTYPLAGWVGAAWGTQASFIAL 375
Cdd:cd17324 281 TLLGPSPLLLLVGLVLWGLGFFAAHSALqTRVLRLAPEARGLAS------SLYLAAYNLGGALGAALGGLVLDHGGWAGV 354
|
330
....*....|....*
gi 636246597 376 TVVATLSLVTAVLIW 390
Cdd:cd17324 355 GWVGAALLLLALLLA 369
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
13-388 |
1.06e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 71.86 E-value: 1.06e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 13 LFMAQVIALIGTGLATVALGLLAYDLAGdrAGAVLGTALAIKMSAYILVAPVAAAFADKFPRRTMLVTLDLVRALVAITL 92
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGG--SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 93 PFVTQIWEIYILIFILQAASAAFTPTFQATIPDILPDEREyTRALSLSRLAYDLESVISPMLAAALLTVMSFHNLFAGTA 172
Cdd:cd17489 79 LLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRR-GEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 173 VGFLASAALVVSVTLPKmkalTVKRSIYDKTTRG-MRIFLKTPRLRGLLALnmaVAAASAMVIVNTVVLVQADFGFSQrs 251
Cdd:cd17489 158 VLALLALLLVFLVKDPP----PVAAEEAEAGTRAfRRLVEKKVLPPALILF---LASIAYGAISTFLPLYAAERGISN-- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 252 TAIALAFFGVGSMVSALVLPRLLDNMSDRMPMLAGTALLVIGLGSGIFLKDYITLVVLWALLGVGYSLSQTPGGRLLRRS 331
Cdd:cd17489 229 AGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDL 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 636246597 332 STAEDRPALFAAQFALSHSCWLVTYPLAGWVGAAWGTQASFIALTVVATLSLVTAVL 388
Cdd:cd17489 309 VPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIF 365
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
5-317 |
5.57e-13 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 70.55 E-value: 5.57e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 5 LSNRTYRHLFMAQVIALIGTGLATVALGLLAYDL-AGDRAGAVLGTALAIKMsayILVAPVAAAFADKFPRRTMLVTLDL 83
Cdd:pfam05977 7 LRQGVFRVIWIASLASNLGTLMQDVAASWLMTSLsASPLMVALVQAAATLPI---FLLSIPAGALADNFDRRKIMLAGQL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 84 VRALVAITLPFVTQI-----WEIYILIFILQAASAAFTPTFQATIPDILPdEREYTRALSLSRLAYDLESVISPMLAAAL 158
Cdd:pfam05977 84 LLALVSTLLTLLAGLgllspWLLLGLTFLGGIGTALMDPAWQASVPELVP-RRDLPAAVALNSVGYNIARSVGPALGGVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 159 LTVMSFHNLFAGTAVGFLASAALVVSVTLPKMKALTVKRSIYDKTTRGMRIFLKTPRLRGLLALNMAVAAASAMVIVNTV 238
Cdd:pfam05977 163 LAAFGPAFTFALNALSYFAVIAALWRWKRAAPASPLPRERIFGAVRAGLRFTAMSRELRSVLVRAFAFGLSASAVWALLP 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 239 VLVQADFGFSQRSTAIALAFFGVGSMVSALVLPRLLDNM-SDRMPMLAGTALLVIGLGSGIFLKDYITLVVLwALLGVGY 317
Cdd:pfam05977 243 LVARDLLDGDAIFYGILLGAVGVGAILGALSLPRLRERLgSDRLVLLASVVTALVLLSLALAPNLWLAIPVL-LLGGAAW 321
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
45-322 |
3.19e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 68.00 E-value: 3.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 45 AVLGTALAIKMSAYILVAPVAAAFADKFP-----RRTMLVTLDLVRALVAITLPFV------TQIWEIYILIFILQAASA 113
Cdd:COG2211 46 ALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTApdlsptGKLIYALVTYLLLGLAYT 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 114 AFTPTFQATIPDILPDEREYTRALSLSRLAYDLESVISPMLAAALLTVMSFHNLFAGTAVGFLASAALVVSVTLPkmkAL 193
Cdd:COG2211 126 LVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLT---FF 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 194 TVKRSIYDKTTRG-----MRIFLKTPRLRGLLALNMAVAAASAMVIVNTVVLVQADFGFSQRSTAIALAFFGVGSMVSAL 268
Cdd:COG2211 203 GTKERPVPEEEKVslkesLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAP 282
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 636246597 269 VLPRLLDNMSDRMPMLAGTALLVIGLGSGIFLK--DYITLVVLWALLGVGYSLSQT 322
Cdd:COG2211 283 LWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILV 338
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
43-388 |
5.06e-12 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 66.83 E-value: 5.06e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 43 AGAVLGTALAIKMSAYILVAPVAAAFADKFPRRTMLvTLDLVRALVAITLPFVTQIWEIYILIFILQAASAAFTPTFQAT 122
Cdd:cd17330 32 SGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVL-LLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAY 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 123 IPDILpDEREYTRALSLSRLAYDLESVISPMLAAALLTVMSFhnlfagTAVGFLASAALVVSVTLpkmkaltvkrsiydk 202
Cdd:cd17330 111 IADIT-DEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGY------ALPFLVAAALALLNLVL--------------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 203 ttrgMRIFLktPRLRGLLALNMAVAAASAMVIVNTVVLVQADFGFSQRSTAIALAFFGVGSMVS-ALVLPRLLDNMSDRM 281
Cdd:cd17330 169 ----VLFFL--PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAqLLLIPRLAKRLGERK 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 282 PMLAGTALLVIGLGSGIFLKDYITLVVLWALLGVGYSLSQTPGGRLLRRSSTAEDRPALFAAQFALSHSCWLVTYPLAGW 361
Cdd:cd17330 243 LLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGP 322
|
330 340
....*....|....*....|....*..
gi 636246597 362 VGAAWGTQASFIALTVVATLSLVTAVL 388
Cdd:cd17330 323 LYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
240-404 |
7.65e-11 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 63.21 E-value: 7.65e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 240 LVQADFGFSQRSTAIALAFFGVGSMVSALVLPRLLDNMSDRMPMLAGTALLVIGLGSGIFLKDYITLVVLWALLGVGYSL 319
Cdd:pfam07690 22 LLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 320 SQTPGGRLLRRSSTAEDRPALFAAQFALSHSCWLVTYPLAGWVGAAWGTQASFIALTVVATLSLVtAVLIWRPEHEVYAQ 399
Cdd:pfam07690 102 LFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAV-LLLLPRPPPESKRP 180
|
....*
gi 636246597 400 VHSHK 404
Cdd:pfam07690 181 KPAEE 185
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
59-322 |
4.28e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 61.05 E-value: 4.28e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 59 ILVAPVAAAFADKFPRRTMLVTLDLVRALVAITLPFVTQIWEIYILIFILQAASAAFTPTFQATIPDiLPDEREYTRALS 138
Cdd:cd17473 49 ALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGD-YFEGEERAKMLG 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 139 LSRLAYDLESVISPMLAAALLTVmSFHNLFAGTAVGFLAsaALVVSVTLPKMKALTVKRSIYDKTTRGMrifLKTPRLRG 218
Cdd:cd17473 128 LQSAAMSLGGVVFLLLGGALAEI-GWRAPFLVYLLALPV--LILVLLFLPEPARKSKSAASPGAATAAA---LPWKRVLP 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 219 LLALNMAVAAASAMVIVNTVVLVQADFGFSQRSTAIALAFFGVGSMVSALVLPRLLDNMSDRMPMLAGTALLVIGLGSGI 298
Cdd:cd17473 202 IYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLA 281
|
250 260
....*....|....*....|....
gi 636246597 299 FLKDYITLVVLWALLGVGYSLSQT 322
Cdd:cd17473 282 LASGLWVVLLGAILAGLGFGLLLP 305
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
45-365 |
8.06e-10 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 60.36 E-value: 8.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 45 AVLGTALAIKMSAYILVAPVAAAFADKF-PRRTMLVTLdLVRALVAITLPFVTQIWEIYILIFILQ-AASAAFTPTFQAT 122
Cdd:cd17355 38 AVISLAFTVGLLAFGLAQPFVGRLLDRFgPRRVMLLGL-LLLAAGLVLLALATSLWQLYLLWGLLGgGGAGTLAAVAFAT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 123 IPDILPDEREyTRALSLSRLAYDLESVISPMLAAALLTVMSFHNLFAGTAVGFLASAALVVSVTLPKMKALTVKRSIYDK 202
Cdd:cd17355 117 VAAWWFERRR-GLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDAS 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 203 TTRGMRIFLKTPRLRG--LLALNMAVAAASAMVIVNTVVLVQADFGFSQRSTAIALAFFGVGSMVSALVLPRLLDNMSDR 280
Cdd:cd17355 196 PASPGSTLKEALRSASfwLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPR 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 281 MPMLAGTALLVIGLGSGIFL-KDYITLVVLWALLGVGYSLSQTPGGRLLRRSSTAEDRPALFAAQFALShscwLVTYPLA 359
Cdd:cd17355 276 RLLAASYALRALGLALLLLLpFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPH----QLGSALG 351
|
....*.
gi 636246597 360 GWVGAA 365
Cdd:cd17355 352 PWLGGL 357
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
13-391 |
1.93e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 59.12 E-value: 1.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 13 LFMAQVIALIGTGLATVALGLLAYDLAGDRAGAvlgtalAIKMSAYILVA----PVAAAFADKFPRRTMLVTLDLVRALV 88
Cdd:cd17474 4 VFFATLLAVLGVSIVDPILPAIAEALGASPAQV------GLLITAFTLPAavlmPVAGVLADRFGRKKVLLPGLLLFGIG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 89 AITLPFVTQIWEIYILIFILQAASAAFTPTFQATIPDILPdEREYTRALSLSRLAYDLESVISPMLAAALLTVmSFHNLF 168
Cdd:cd17474 78 GLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFE-GGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 169 AGTAVGFLAsAALVVSVTLPKMKALTVKRSIYDKttRGMRIFLKTPRLRGLLALNMAVAAASAMVIVNTVVLVQADFGFS 248
Cdd:cd17474 156 FLLAALIPV-AFLAILFLLPEPKEKAKSSSATKL--RDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGIS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 249 QRSTAIALAFFGVGSMVSALVLPRLLDN-MSDRMPMLAGTALLVIGLGSGIFLKDYITLVVLWALLGVGYSLSQTPGGRL 327
Cdd:cd17474 233 PIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 636246597 328 LRRSSTAEDRPALFAAQFALSHSCWLVTYPLAGWVGAAWGTQASFIALTVVAtlsLVTAVLIWR 391
Cdd:cd17474 313 VTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIA---LAAAVLLAL 373
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
45-393 |
3.32e-09 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 58.35 E-value: 3.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 45 AVLGTALAIKMSAYILVAPVAAAFADKFPRRTMLVTLDLVRALVAITLPFVTQIWEIYILIFILQAASAAFTPTFQATIP 124
Cdd:COG2223 40 AQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVS 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 125 DILPDEReYTRALSLSRLAYDLESVISPMLAAALLTVMSFHNLFAGTAVGFLASAALVVSVT--LPKMKALTVKRSIydk 202
Cdd:COG2223 120 KWFPPDR-RGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLrdPPAGAAAAAKASL--- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 203 ttRGMRIFLKTPRLRGLLALNMAVAAASAMVIVNTVVLVQADFGFSQRSTAIALAFFGVGSMVSALVLPRLLDNMSDRMP 282
Cdd:COG2223 196 --RDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRV 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 283 MLAGTALLVIG-LGSGIFLKDYITLVVLWALLGVGYSLSQTPGGRLLRRSSTAEDRPALFAAQFALSHSCWLVTYPLAGW 361
Cdd:COG2223 274 LLIVFALMALGlLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGA 353
|
330 340 350
....*....|....*....|....*....|...
gi 636246597 362 VGAAWGT-QASFIALTVVATLSLVTAVLIWRPE 393
Cdd:COG2223 354 LLDATGSyTAAFLVFAVLALVALVLTLLLYRRP 386
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
6-392 |
6.34e-09 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 57.58 E-value: 6.34e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 6 SNRTYRHLFMAQVIALIGTGLAT------VALGLLAYDLAGDRAGAVLGTALAikMSAYILVAPVAAAFADKF-PRRTML 78
Cdd:COG2807 10 RSRRAGRWLLLLAIVLVALNLRPaitsvgPLLPEIRADLGLSATQAGLLTTLP--LLAFGLFAPLAPRLARRFgLERTLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 79 VTLdLVRALVAITLPFVTQIWEIYILIFILQAASAAFTPTFQATIPDILPDEReyTRALSLSRLAYDLESVISPMLAAAL 158
Cdd:COG2807 88 LAL-LLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRV--GLMTGLYTAAMGLGAALAAGLTVPL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 159 LTVMSFHNLFAGTAVgFLASAALVVSVTLPKMKALTVKRSiydkTTRGMRIFLKTPRLRgLLALNMAVAAASAMVIVNTV 238
Cdd:COG2807 165 AAALGWRGALAVWAL-LALLALLLWLPLLRRRPAAAAAAP----AAASLRSLWRSPLAW-LLTLFFGLQSLLYYAVVAWL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 239 VLVQADFGFSQRSTAIALAFFGVGSMVSALVLPRLLDNMSDRMPMLAGTALLVIgLGSGIFLKDYITLVVLWA-LLGVGY 317
Cdd:COG2807 239 PPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGL-AGLLGLLLAPGSLPWLWAvLLGLGQ 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 636246597 318 SLSQTPGGRLL-RRSSTAEDRPALFAAQFALSHSCWLVTYPLAGWVGAAWGT-QASFIALTVVATLSLVTAVLIWRP 392
Cdd:COG2807 318 GGLFPLALTLIgLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSwTAALLLLAALAVLMLVAGLLAGRP 394
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
240-391 |
8.54e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 56.91 E-value: 8.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 240 LVQADFGFSQRSTAIALAFFGVGSMVSALVLPRLLDNMSDRMPMLAGTALLVIGLGSGIFLKDYITLVVLWALLGVGYSL 319
Cdd:COG2814 35 LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGA 114
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 636246597 320 SQTPGGRLLRRSSTAEDRPALFAAQFALSHSCWLVTYPLAGWVGAAWGTQASFIALTVVATLSLVTAVLIWR 391
Cdd:COG2814 115 LFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLP 186
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
13-323 |
6.99e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 54.10 E-value: 6.99e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 13 LFMAQVIALIGTGLATVALGLLAYDLAGDraGAVLGTALAIKMSAYILVAPVAAAFADKFPRRTMLVTLDLVRALVAITL 92
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGAS--PSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLC 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 93 PFVTQIWEIYILIFILQAASAAFTPTFQATIPDILPDEReYTRALSLSRLAYDLESVISPMLAAALLTVMSFHNLFagta 172
Cdd:cd17321 79 ALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGER-RGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIF---- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 173 vGFLASAALVVsvtlpkmkaltvkrsiydkttrgmriFLKTPRLRGLLALNMAVAAASAMVIVNTVVLVQADFGFSQRST 252
Cdd:cd17321 154 -LINVPIGLVA--------------------------LLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQA 206
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 636246597 253 AIALAFFGVGSMVSALVLPRLLDNMSDRMPMLAGTALLVIGLGSGIFLK---DYITLVVLWALLGVGYSLSQTP 323
Cdd:cd17321 207 GLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGadsSVWLLLPGLVLLGLGLGLFATP 280
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
237-396 |
7.37e-08 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 53.97 E-value: 7.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 237 TVVLVQADFGFSQRSTAIALAFFGVGSMVSALVLPRLLDNMSDRMPMLAGTALLVIGLGSGIFLKDYITLVVLWALLGVG 316
Cdd:cd06174 18 LLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 317 YSLSQTPGGRLLRRSSTAEDRPALFAAQFALSHSCWLVTYPLAGWVgAAWGTQASFIALTVVATLSLVTAVLIWRPEHEV 396
Cdd:cd06174 98 SGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGIL-ASSLGFGWRAVFLIAAALALLAAILLLLVVPDP 176
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
13-294 |
3.78e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 51.35 E-value: 3.78e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 13 LFMAQVIALIGTGLATVALGLLAYDLAGDraGAVLGTALAIKMSAYILVAPVAAAFADKFPRRTMLVTLDLVRALVAITL 92
Cdd:COG0477 19 LALGTFLEGLDFTIVNVALPSIAADLGAS--SAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLC 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 93 PFVTQIWEIYILIFILQAASAAFTPTFQATIPDILPDeREYTRALSLSRLAYDLESVISPMLAAALLTVMSFHNLFAGTA 172
Cdd:COG0477 97 GLAPSPELLIAARALQGIGAGGLMPGALALIAELFPA-RERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 173 VgfLASAALVVSVTLPKMKALTVKRSIYDKTTRGMRIFLKTPRLRGLLALNMAVAAASAMVIVNTVVLVQADFGFSQRST 252
Cdd:COG0477 176 P--LGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLL 253
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 636246597 253 AIALAFFGVGSMVSALVLPRLLDNMSDRMPMLAGTALLVIGL 294
Cdd:COG0477 254 LALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
19-386 |
5.78e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 51.41 E-value: 5.78e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 19 IALIGTGLATVALGLLAYDLAGDraGAVLGTALAIKMSAYILVAPVAAAFADKFPRRTMLVTLDLVRALVAITLPFVTQI 98
Cdd:cd17477 7 LLGLGSGLLLPLLSLRLEREGVS--TALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 99 WEIYILIFILQAASAAFTPTFQATIPDILPDEREyTRALSLSRLAYDLESVISPMLAAALLTVMsfhNLFAGTAVGFLAS 178
Cdd:cd17477 85 WVWFLLRFVMGIGLAGLFVVSESWLNALATNENR-GRVLGLYSTVLGLGFALGPLLLALVGTAG---ALPFLIAAVLLLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 179 AALVVSVTLPKMKALTVKRSIydkttRGMRIFLKTPrlrgLLALNMAVAAASAMVIVNTVVLVQADFGFSQRSTAIALAF 258
Cdd:cd17477 161 ALVPLLLTRRAAPEIEEAESI-----SLRRLLRIAP----LALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 259 FGVGSMVSALVLPRLLDNMsDRMPMLAGTALLVIGLGSGIFLKD--YITLVVLWALLGVG----YSLSQTPGGRLLRRSs 332
Cdd:cd17477 232 FVLGGLLLQWPLGWLADRF-DRRRVLLGCALLGALAALLLPLVPglPLALLVLLFLWGGAagplYTLALALAGDRLPGD- 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 636246597 333 taeDRPALFAAqFALSHSCWLVTYP-LAGWVGAAWGTQASFIALTVVATLSLVTA 386
Cdd:cd17477 310 ---ELVAANAA-LLLLYGLGSVIGPlLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| PRK10489 |
PRK10489 |
enterobactin transporter EntS; |
7-192 |
2.26e-06 |
|
enterobactin transporter EntS;
Pssm-ID: 236700 [Multi-domain] Cd Length: 417 Bit Score: 49.59 E-value: 2.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 7 NRTYRHLFMAQVIALIGTGLATVALGLLAYDLAGD--RAGAVLgTALAIKMSAYILVAPVaaaFADKFPRRTMLVtldLV 84
Cdd:PRK10489 16 HPAFRAVFIARFISIFGLGLLGVAVPVQIQMMTGStlQVGLSV-TLTGGAMFIGLMVGGV---LADRYDRKKLIL---LA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 85 RAlvAITLPFVT----------QIWEIYILIFILQAASAAFTPTFQATIPDILPDEReYTRALSLSRLAYDLESVISPML 154
Cdd:PRK10489 89 RG--TCGLGFIGlalnaflpepSLLAIYLLGLWDGFFGSLGVTALLAATPALVGREN-LMQAGAITMLTVRLGSVISPAL 165
|
170 180 190
....*....|....*....|....*....|....*...
gi 636246597 155 AAALLTVMSFHNLFAGTAVGFLASAALVvsVTLPKMKA 192
Cdd:PRK10489 166 GGLLIAAGGVAWNYGLAAAGTFITLLPL--LRLPALPP 201
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
57-182 |
2.65e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 49.19 E-value: 2.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 57 AYILVAPVAAAFADKF-PRRTMLVTLdLVRALVAITLPFVTQIWEIYILIFILQAASAAFTPTFQATIPDILPDEREyTR 135
Cdd:cd17391 252 SSLLSAPRLGKLGDRIgHHRILLGAL-LASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVA-GR 329
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 636246597 136 ALSLSRLAYDLESVISPMLAAALLTVMSFHNLFAGTAVGFLASAALV 182
Cdd:cd17391 330 IFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWS 376
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
237-393 |
2.91e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 49.16 E-value: 2.91e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 237 TVVLVQADFGFSQRSTAIALAFFGVGSMVSALVLPRLLDNMSDRMPMLAGTALLVIGLGSGIFLKDYITLVVLWALLGVG 316
Cdd:cd17475 18 LAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 317 YSLSQTPGGRLLRRSSTAEDRP-ALFAAQFALshscwlvtyPLAGWVGAA--------WGTQASFIALTVVATLSLVTAV 387
Cdd:cd17475 98 YGSVQPGGGRAIMRWFPPRERGlAMGIRQTGV---------PLGGALAAAllpplalhYGWRAAFVVAGLVSILAAVLFW 168
|
....*.
gi 636246597 388 LIWRPE 393
Cdd:cd17475 169 LFYREP 174
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
63-389 |
2.41e-05 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 46.06 E-value: 2.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 63 PVAAAFADKFPRRTMLVTLDLVRALVAITLPFVTQIWEIYiLIFILQAASAAFtPTFQATIPDILPDErEYTRALSLSRL 142
Cdd:cd17331 53 PLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLF-LSRLPSVFMHAM-QAAQMVVTDLTDPG-ERAAALGRLGL 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 143 AYDLESVISPMLAAALLTVMSFHNLFAGTAVGFLASAALVVsVTLPK-MKALTVKRSIYDKTTRG------MRIFLKTPR 215
Cdd:cd17331 130 SYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVI-LLIPSnTKSKREKEAKESASPPSvfnlkeILRLLRLPG 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 216 LRGLLALNMAVAA-ASAMVIVNTVVLVQAdFGFSQRSTAIALAFFGVGSMVS-ALVLPRLLDNMSDRMPMLAGTALLVIG 293
Cdd:cd17331 209 VAFLLLVKLLSGLpIGMFQSMFSLVAMDF-FGLTPEENGYLMSYAGVLGMVVqGLLVGPLTKRFGERSLLKLSVALLAIG 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 294 LGSGIFLKDYITLVVLWALLGVGYSLSQTPGGRLLRRSSTAEDRPALFAAQFALSHSCWLVTYPLAGWVGAAWGTQAsfI 373
Cdd:cd17331 288 YLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPS--F 365
|
330
....*....|....*.
gi 636246597 374 ALTVVATLSLVTAVLI 389
Cdd:cd17331 366 GLLGAAINGLLTVYLL 381
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
55-323 |
2.61e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 46.03 E-value: 2.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 55 MSAYILVA----PVAAAFADKFPRRTMLVTLDLVRALVAITLPFVTQIWEIyILIFILQAASAAF-TPTFQATIPDILPd 129
Cdd:cd17503 37 ITSYLLALaimiPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASL-IIFRILQGFGGGVlIPLAQTILLRIYP- 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 130 EREYTRALSLSRLAYDLESVISPMLAAALLTVMSFHNLFagtavgFLASAALVVSVTLPKMKALTVkrsiydkttrgmri 209
Cdd:cd17503 115 PEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIF------YINLPIGILALLLAPLLDLRL-------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 210 fLKTPRLRGLLALNMAVAAASAMVIVNTVVLVQADFGFSQRSTAIALAFFGVGSMVSALVLPRLLDNMSDRMPMLAGTAL 289
Cdd:cd17503 175 -FKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLL 253
|
250 260 270
....*....|....*....|....*....|....*..
gi 636246597 290 LVIGLGSGIFL---KDYITLVVLWALLGVGYSLSQTP 323
Cdd:cd17503 254 LALGTLLLAFLtpdTSLWLIILPLFIRGLGMGLVFMP 290
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
13-172 |
2.89e-05 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 46.07 E-value: 2.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 13 LFMAQVIALIGTGLATVALGLLAYDLAGDRAGAVL--GTALAIKMSAYILVAPVAAAFADKFPRRTMLVTLDLVRALVAI 90
Cdd:PRK09874 224 LFVTTLIIQVATGSIAPILTLYVRELAGNVSNIAFisGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLI 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 91 TLPFVTQIWEIYILIFILQAASAAFTPTFQaTIPDILPDEREYTRALSLSRLAYDLESVISPMLAAALLTVMSFHNLFAG 170
Cdd:PRK09874 304 PMSFVQTPLQLGILRFLLGAADGALLPAVQ-TLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISANYGFRAVFLV 382
|
..
gi 636246597 171 TA 172
Cdd:PRK09874 383 TA 384
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
68-320 |
5.75e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 44.87 E-value: 5.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 68 FADKFPRRTMLVTLDLVRALVAITLPFVTQIWEIYILIFIlQAASAAFTPTFQATIPDILPDEREYTRALSLSRLAYDLE 147
Cdd:cd17320 57 LSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFL-QGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIA 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 148 SVISPMLAAALLTVMSFHNLFAgtavgFLASAALVVSV--------TLPKMKALTVKRSIYdkttRGMRIFLKTPRLRGL 219
Cdd:cd17320 136 PALAPLLGGLLLLFFGWRAIFV-----FLALLGLLLLLlvllflpeTLPEEKRKPLLSSLL----RAYKRVLKNRRFLGY 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 220 LALNMAVAAASAMVIVNTVVLVQADFGFSQRSTAIALAFFGVGSMVSALVLPRLLDNMSDRMPMLAGTALLVIG-----L 294
Cdd:cd17320 207 ALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAalvllL 286
|
250 260
....*....|....*....|....*.
gi 636246597 295 GSGIFLKDYITLVVLWALLGVGYSLS 320
Cdd:cd17320 287 AALLGGLSLWPLVAPLFLIFFGFGLI 312
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
238-391 |
7.29e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 44.87 E-value: 7.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 238 VVLVQADFGFSQRSTAIALAFFGVGSMVSALVLPRLLDNMSDRMPMLAGTALLVIGLGSGIFLKDYITLVVLWALLGVGY 317
Cdd:COG2223 28 APPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGG 107
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 636246597 318 SLSQTPGGRLLRRSSTAEDRPALFAAQFALSHSCWLVTYPLAGWVGAAWGTQASFIaltVVATLSLVTAVLIWR 391
Cdd:COG2223 108 GGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL---ILGILLLVVAVLAWL 178
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
40-192 |
1.39e-04 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 44.53 E-value: 1.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 40 GDRAGAVLGTALAIKMSAYILVAPVAAAFADKFPRRTMLVTLDLVRALV--AITLPFVTQ-IWEIYILIFILQAASAAFT 116
Cdd:PRK08633 42 GSEQVILTAIVNALFLLPFLLLSSPAGFLADKFSKNRVIRIVKLFEVGLtlLIVLAYYLGwFWLAFAVTFLLGAQSAIYS 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 117 PTFQATIPDILPDEReytralsLSRLAYDLESV-ISPMLAAALLTVMSFHNLFAGTAVGFLASAA-------------LV 182
Cdd:PRK08633 122 PAKYGIIPELVGKEN-------LSRANGLLEAFtIVAILAGTALFSFLFESVNGNTPSEILGRIApaglvllavavlgLI 194
|
170
....*....|
gi 636246597 183 VSVTLPKMKA 192
Cdd:PRK08633 195 FAYRLPKVPA 204
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
29-391 |
1.55e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 43.71 E-value: 1.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 29 VALGLLAYDLAGDRAgaVLGTALAIKMSAYILVAPVAAAFADKFPRRTMLVTLDLVRALVAITLPFVTQIWEIYILIFIL 108
Cdd:cd17319 24 VAAPTIMKDLGLSPT--QYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 109 QAASAAFTPTFQATIPDILPdEREYTRALSLSRLAYDLESVISPMLAAALLTVMSFHNLFAGTAV-GFLasAALVVSVTL 187
Cdd:cd17319 102 GVAEAGFFPGAIKALAEWFP-ARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLlGLL--LAVLWWFYL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 188 PKMKALTVKRSIYDKTTRGMRIFLKTprlrgllalnmavaaasamvivntvvLVQADFGFSQRSTAIALAFFGVGSMVSA 267
Cdd:cd17319 179 RQVWGLALGYFGINYALYGLLTWLPT--------------------------YLKQARGFSLKQVGLLAAIPFLAGAIGM 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 268 LVLPRLLDNMSD---RMPMLAGTALLVIGLGSGIFLKDYITLVVLWALLGVGYSLSQTPGGRLLRRSSTAEDRPALFAAQ 344
Cdd:cd17319 233 ILGGRLSDRLLRgarRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLI 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 636246597 345 FALSHSCWLVTYPLAGWVGAAWGTQASfiALTVVATLSLVTAVLIWR 391
Cdd:cd17319 313 NSGGNLGGFVAPLLIGYLVDATGSYTA--AFLFLAAVALLAALLVLL 357
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
59-183 |
3.83e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 42.53 E-value: 3.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 59 ILVAPVAAAFADK-FPRRTMLVTLDLVRALVAITLPFVTQIWEIYILIFILQAASAAFTPTFQATIPDIL--PDEREYTR 135
Cdd:cd17471 46 IVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLFAFLRNYWVLLLVGVVLLSLGAAAFPQLFALAREYAdrSSGRDATL 125
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 636246597 136 ALSLSRLAYDLESVISPMLAAALLTVMSFHNLFAGTAVGFLASAALVV 183
Cdd:cd17471 126 FNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVL 173
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
234-388 |
4.25e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 42.23 E-value: 4.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 234 IVNTVVLVQADFGFSQRSTAIALAFFGVGSMVSALVLPRLLDNMSDRMPMLAGTALLVIGLGSGIFLKDYITLVVLWALL 313
Cdd:cd17313 265 VYHGTSAASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALG 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 314 GVGYSLSQTPGGRLLRRSSTAEDRP----------ALFAAQFALShscwlvtyPLAGWVGAAWGTQASFIALTVVATLSL 383
Cdd:cd17313 345 GIGWATININPYPLVSDYHSESGRGqgtdtgllnlAISLAQILVS--------LLAGPIIDVKGYGTVFPVAAVASFLSL 416
|
....*
gi 636246597 384 VTAVL 388
Cdd:cd17313 417 VGALF 421
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
26-139 |
4.44e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 42.22 E-value: 4.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 26 LATVALGLLAYDLAGDRAGAVLGTALAIkmsAYILVAPVAAAFADKFPRRTMLVTLDLVRALVAITLPFVTQIWEIYILI 105
Cdd:cd17328 18 IAGVLPDIQSDFLIDDSLAGLLQTVFII---SYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFR 94
|
90 100 110
....*....|....*....|....*....|....
gi 636246597 106 FILQAASAAFTPTFQATIPDILPDEREyTRALSL 139
Cdd:cd17328 95 ALVGIGEASYSPIAPTIIADLFPKEKR-TRALGV 127
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
242-393 |
5.67e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 41.87 E-value: 5.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 242 QADFGFSQRSTAIALAFFGVGSMVSALVLPRLLDNMSDRMPMLAGTALLVIGLGSGIFLKDYITLVVLWALLGVGySLSQ 321
Cdd:cd17355 30 IAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGG-GAGT 108
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 636246597 322 TPGGRLLRRSSTAEDRPALFAAQFALSHSCW--LVTYPLAGWVGAAWGTQASFIALTVVATLSLVTAVLIWRPE 393
Cdd:cd17355 109 LAAVAFATVAAWWFERRRGLALGILTAGGGLgsLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRR 182
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
238-394 |
5.95e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 41.83 E-value: 5.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 238 VVLVQADFGFSQRSTAIALAFFGVGSMVSALVLPRLLDNMSDRMPMLAGTALLVIGLGSGIFLKDYITLVVLWALLGVGY 317
Cdd:cd17329 23 AIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 318 SLSQTPGGRLLRRSSTAEDRPALFAAQFALSHSCWLVTYPLAGWVGaawgtQASFIALTVVATLSLVTAVLI---WRPEH 394
Cdd:cd17329 103 GLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL-----LYSFRLLFLAAAVLFLLAALVllfLLPET 177
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
243-396 |
7.32e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 41.41 E-value: 7.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 243 ADFGFSQRSTAIALAFFGVGSMVSALVLPRLLDNMSDRMPMLAGTALLVIGLGSGIFLKDYITLVVLWALLGVGYSLSQT 322
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWP 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 636246597 323 PGGRLLRRSSTAEDRPALFAAQFALSHSCWLVTYPLAGWVGAAWGTQASFIALTVVATLSLVTAVLIWRPEHEV 396
Cdd:cd17325 104 AAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPP 177
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
55-336 |
9.05e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 41.41 E-value: 9.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 55 MSAYILVAPVAAAF----ADKFPRRTMLVTLDLVRALVAITLPFVTQIWeIYILIFILQAASAAFTPTFQATIPDILPDE 130
Cdd:cd17504 37 LTAYLLVGAVSTPIlgrlGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLP-VLIAGRALQGIGGAVFPLAFALVREEFPPE 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 131 REYTrALSLSRLAYDLESVISPMLAAALLTVMSFHNLFAGTAVGFLASAALVVSVTLpkmkaltvkrsiydkttrgmRIF 210
Cdd:cd17504 116 RVPV-AQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLIDL--------------------RLL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 211 lktpRLRGLLALNMAVAAASAMVIVNTVVLVQ-------ADFGFSQRSTAIALAFFGVGSMVSALVLPRLLDNMSDRMPM 283
Cdd:cd17504 175 ----RRRNVLLANITALLAGFGMFMVFQLLPQllqlptpTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVL 250
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 636246597 284 LAGTALLVIG-LGSGIFLKDYITLVVLWALLGVGYSLSQTPGGRLLRRSSTAED 336
Cdd:cd17504 251 LIGLVISAVGlLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDR 304
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
68-384 |
1.02e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.99 E-value: 1.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 68 FADKFPRRTMLVTLD-LVRALVAITLPFVTQIWEIYILIFILQAASAAFTPTFQATIPDILPDErEYTRALSLSRLAYDL 146
Cdd:cd17370 57 LSDRTGKRKPLVILGyGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPS-GRGKAFGLHRALDTL 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 147 ESVISPMLAAALL--TVMSFHNLFAGTAV-GFLASAALVVSVTLPKMKALTVKRSIYDKTTRGMRIFlktPRLRGLLALN 223
Cdd:cd17370 136 GAVLGPLLAALLLylLGGNYRTIFLLAAIpALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAF---WLYLLAVALF 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 224 MAVAAASAMVIVNTvvlvqADFGFSQRSTAIALAFFGVGSMVSALVLPRLLDNMSDRMPMLAGTALLVIGLGSGIFLKDY 303
Cdd:cd17370 213 ALGNFSFAFLILRA-----QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSL 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 304 ITLVVLWALLGVGYSLSQTpggrlLRRSSTAEDRPA--------LFAAQFALShscWLVTYPLAGWVGAAWGTQASFIAL 375
Cdd:cd17370 288 WLLLLGFILWGLYMGAQES-----IERAAVADLVPAelrgtaygLFNTVVGIG---WLLASLIAGYLWDLISPSAAFLFS 359
|
....*....
gi 636246597 376 TVVATLSLV 384
Cdd:cd17370 360 AVLALIALL 368
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
48-390 |
1.04e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 41.10 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 48 GTALAIKMSAYILVAPVAAAFADKFPRRTMLVTLDLVRALVAITLPFVTQIWEIYILiFILQAASAAFTPTFQATIPDIL 127
Cdd:cd17391 39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLIL-RLLQGVFSGYVPNATALIASQT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 128 PDEREyTRALSLSRLAYDLESVISPMLAAALLTVMSFHNLFAGTAVGFLASAALVVSVTLPKMKALTVKRSIydkttRGM 207
Cdd:cd17391 118 PKEKS-GWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKEDFKPVEKKKMV-----STK 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 208 RIFLKTPRLRGLLAL--NMAVAAASAMVIVNTVVLVQADFGFSQRSTA----IALAFFGVGSMVSALVLPRLLDNMSDRM 281
Cdd:cd17391 192 EVWNSVPNPSLLISLfvTTFIIQLANQSIEPILTLYIRQLMGDASNLAfisgLVFSATGVSSLLSAPRLGKLGDRIGHHR 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 282 PMLAGTALLVIGLGSGIFLKDYITLVVLWALLGVGYSLSQTPGGRLLRRSSTAEDRPALFA-AQFALSHSCwlVTYPLAG 360
Cdd:cd17391 272 ILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGyNQSFQYLGN--VAGPLLG 349
|
330 340 350
....*....|....*....|....*....|.
gi 636246597 361 -WVGAAWGTQASFialtvVATLSLVTAVLIW 390
Cdd:cd17391 350 sAIAAHFGYRAVF-----VVTALLVLLNAIW 375
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
241-394 |
1.05e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 41.01 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 241 VQADFGFSQRSTAIALAFFGVGSMVSALVLPRLLDNMSDRMPMLAGTALLVIGLGSGIFLKDYITLVVLWALLGVGYSLS 320
Cdd:COG2807 44 IRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVG 123
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 636246597 321 QTPGGRLLRRSstAEDRPALFAAQFALSHSCW-LVTYPLAGWVGAAWGTQASFIALTVVATLSLVTAVLIWRPEH 394
Cdd:COG2807 124 NVLLPGLIKRW--FPDRVGLMTGLYTAAMGLGaALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRP 196
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
13-185 |
3.88e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.12 E-value: 3.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 13 LFMAQVIALIGTGLATVALGLLAYDLAGDRAGAVLGTALAikmsAYILVAPVAAAFADKFPRRTMLVTLDLVRALVAITL 92
Cdd:cd17316 185 LWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISL----GALVGALIAGLLSDRIGRKKTLVIGLILSGILALPL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 93 PFVTQ--IWEIYILIFILQAASAAFTPTFQATIPDILPDEREYTR---ALSLSRLAydleSVISPMLAAALLTVMSFHNL 167
Cdd:cd17316 261 FYLLSgsPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGvglSYNLGRLG----GGGAPPLIALLLASTGGTGV 336
|
170
....*....|....*...
gi 636246597 168 FAgTAVGFLASAALVVSV 185
Cdd:cd17316 337 PA-LILALLAIVALIVAL 353
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
58-316 |
4.84e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 38.84 E-value: 4.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 58 YILVAPVAAAFADKFPRRTMLVTLDLVRALVAITLPFVTQIWEIYILIFILQAASAAFTPTFQATIPDILPdeREYTRAL 137
Cdd:cd17333 44 YLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFE--ESSATRL 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 138 SLSRLAYDLESVISPMLAAALLT-VMSFHNLFAGTAvgfLASAALVVSVTLPKMKALTVKRSIYDKTTRGMRIFLKTPRL 216
Cdd:cd17333 122 NVLHGFFGLGALIGPLIATSLLTsELSWSWAYLIIG---LIYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRN 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 217 RG--LLALNMAVAAASAMVIVNTV-VLVQADFGFSQRSTAIALAFFGVGSMVSALVLPRLLDNMSDRMPMLAGTALLVIG 293
Cdd:cd17333 199 PSiiLGALALFLYVGAETAFSSWVpSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLG 278
|
250 260
....*....|....*....|...
gi 636246597 294 LGSGIFLKDYITLVVLWALLGVG 316
Cdd:cd17333 279 LLILLLAPTLVVGLVATALLGLF 301
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
234-389 |
8.89e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 37.87 E-value: 8.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636246597 234 IVNTVV-LVQADFGFSQRSTAIALAFFGVGSMVSALVLPRLLDNMSDRMPMLAGTALLVIGLGSGIFLKDYITLVVLWAL 312
Cdd:COG0477 32 IVNVALpSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARAL 111
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 636246597 313 LGVGYSLSQTPGGRLLRRSSTAEDRPALFAAQFALSHSCWLVTYPLAGWVGAAWGTQASFIALTVVATLSLVTAVLI 389
Cdd:COG0477 112 QGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRL 188
|
|
| |
