|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10764 |
PRK10764 |
potassium-tellurite ethidium and proflavin transporter; Provisional |
5-304 |
3.52e-163 |
|
potassium-tellurite ethidium and proflavin transporter; Provisional
Pssm-ID: 236756 Cd Length: 324 Bit Score: 457.87 E-value: 3.52e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 5 NKPQQVLNLPAGYFGMVLGIIGMGFAWRYASTLWPVTRWPGEGLVALAVICWFLLTVAFVTRAIRFPRSVLAEMRHPVMS 84
Cdd:PRK10764 1 MQSDKVLPLPAGYFGIVLGLIGLGFAWRYAAQLWPLPAWIGEALVALASIIWALLILAYLYKWIRFPESVLAELRHPVQS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 85 SFVSLFPATTMLVAIGFVPWFRAVSLALFGIGVVVQLAYSAWQSAGLWRGKHPQEATTPGLYLPTVANNFISAMACGALG 164
Cdd:PRK10764 81 SFVSLIPITTMLVAIGLVPYSRPLAVVLFSFGVVGQLAFAAWRTAGLWRGGHPEEATTPGLYLPTVANNFVSAMALGALG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 165 FNDAGLVFLGAGVFSWLSLEPVILQRLRSAGELPSALRTSLGIQLAPALVACSAWFSVNGGQADTFAKMLFGYGLLQLLF 244
Cdd:PRK10764 161 YHDAGLLFLGAGVFSWLSLEPVILQRLRSSGELPTALRPSLGIQLAPAFVGCSAYLSVNGGEGDTLAKMLFGYGLLQLLF 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 245 MLRLMPWYLSQPFNASFWSFSFGVSALATTGLHLGQSSPTGFFHAIAVPLFIFTNAIIGW 304
Cdd:PRK10764 241 LLRLMPWILSQGFNASFWSFSFGVAALATTGLHLGHGSDNGFFHTLAVPLFIFANFIIAL 300
|
|
| TDT_TehA |
cd09324 |
Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; This ... |
14-304 |
1.10e-127 |
|
Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; This subfamily includes Tellurite resistance protein TehA that belongs to the C4-dicarboxylate transporter/malic acid transport (TDT) protein family and is a homolog of plant Slow Anion Channel-Associated 1 (SLAC1). The tehA gene encodes an integral membrane protein that has been shown to have efflux activity of quaternary ammonium compounds. TehA protein of Escherichia coli functions as a tellurite-resistance uptake permease.
Pssm-ID: 187764 Cd Length: 301 Bit Score: 366.98 E-value: 1.10e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 14 PAGYFGMVLGIIGMGFAWRYASTLWPVTRWPGEGLVALAVICWFLLTVAFVTRAIRFPRSVLAEMRHPVMSSFVSLFPAT 93
Cdd:cd09324 1 PVGYFGIVLGLAALGLAWRYAAQLWPLPAIVGESLLALASVVWLLLIGAYAYKWLKYREEARAELRHPVQCCFISLIPIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 94 TMLVAIGFVPWFRAVSLALFGIGVVVQLAYSAWQSAGLWRGKHPQEATTPGLYLPTVANNFISAMACGALGFNDAGLVFL 173
Cdd:cd09324 81 TMLVGIALYPYSRLLAEVLIVLGIIGQLAFAAWRTGGLWQGGHFPEATTPVLYLPTVAGNFVSASALAALGYHDLGMLFF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 174 GAGVFSWLSLEPVILQRLRSAGELPSALRTSLGIQLAPALVACSAWFSVNGGQADTFAKMLFGYGLLQLLFMLRLMPWYL 253
Cdd:cd09324 161 GAGMFSWLSLEPVILQRLRTSPPLPPALRPTLGIQLAPAFVGCSAYLSLNGGEVDLLAKMLWGYGLLQLLFLLRLLPWIA 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 635780967 254 SQPFNASFWSFSFGVSALATTGLHLGQSSPTGFFHAIAVPLFIFTNAIIGW 304
Cdd:cd09324 241 EQGFSMGFWAFSFGLAAMATSGLHLYHGGVLGPLSLLALALFNVANGLIAL 291
|
|
| tdt |
TIGR00816 |
C4-dicarboxylate transporter/malic acid transport protein; The Tellurite-Resistance ... |
13-303 |
4.93e-83 |
|
C4-dicarboxylate transporter/malic acid transport protein; The Tellurite-Resistance/Dicarboxylate Transporter (TDT) Family (TC 2.A.16)Two members of the TDT family have been functionally characterized. One is the TehA protein of E. coli which has been implicated in resistance to tellurite; the other is the Mae1 protein of S. pombe which functions in the uptake of malate and other dicarboxylates by a proton symportmechanism. These proteins exhibit 10 putative transmembrane a-helicalspanners (TMSs). [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273285 Cd Length: 320 Bit Score: 254.25 E-value: 4.93e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 13 LPAGYFGMVLGIIGMGFAWRYASTLWPVTRWPGEGLVALAVICWFLLTVAFVTRAIRFPRSVLAEMRHPVMSSFVSLFPA 92
Cdd:TIGR00816 1 FPWGWFAIVLGTGGLALASLSYSFYLPILKDLSDVLFILAIALFFLFTSCWLARLIRYPSNVLAELKHPVLSSFIPLIPI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 93 TTMLVAIGFVPWFRAVSLALFGIGVVVQLAYSAWQSAGLWRG-KHPQEATTPGLYLPTVANNFISAMACGALGFNDAGL- 170
Cdd:TIGR00816 81 STMLLGIDFIIWGYPLALGLWYIGAIGQLLFSVIVPFYLFKNeSIEIEHTHPGWYLPPVALIFISAAALAILPYLTHELt 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 171 ----VFLGAGVFSWLSLEPVILQRLRSAGELPSALRTSLGIQLAPALVACSAWFS-VNGGQADT-------FAKMLFGYG 238
Cdd:TIGR00816 161 vlfyFGWGAGFFLYLSLEAVLLLRLRLHGLLPSALRPTMFINLAPIGVGIVALINiVNHGEFITikepfliLAIILWGFG 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 635780967 239 LLQLLFMLRLMPWYLSQ--PFNASFWSFSFGVSALATTGLHLGQSSPTGFFHAIAVPLFIFTNAIIG 303
Cdd:TIGR00816 241 LWQLLFAIRLLLWYVKLklPFAMGWWAFIFPLAAYANSTHLVYKGFDFKVFQYIGFGLYVFLNFFWA 307
|
|
| TehA |
COG1275 |
Tellurite resistance protein TehA and related permeases [Defense mechanisms]; |
5-304 |
1.52e-79 |
|
Tellurite resistance protein TehA and related permeases [Defense mechanisms];
Pssm-ID: 440886 Cd Length: 323 Bit Score: 245.15 E-value: 1.52e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 5 NKPQQVLNLPAGYFGMVLGIIGMGFAWRYASTLWPVTRWPGEGLVALAVICWFLLTVAFVTRAIRFPRSVLAEMRHPVMS 84
Cdd:COG1275 4 APRSRLRNLPPAWFALVMGTGGLGLAWRLAAALLPGPAAIAEVLLALAALLFLVLLLLYLLKWLRYPAAVRADLRHPVRG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 85 SFVSLFPATTMLVAIGFVPWFRAVSLALFGIGVVVQLAYSAWQSAGLWRG-KHPQEATTPGLYLPTVANNFISAMACGAL 163
Cdd:COG1275 84 SFFPTIPMALLLLGTGLLPLAPALALVLWLLGVALHLALTVYFPYRLFTGeKFEIEHITPAWFIPVVGNIVVAVAGALLG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 164 GFNDAGLVFLGAGVFSWLSLEPVILQRLRSAGELPSALRTSLGIQLAPALVACSAWFSVNGGQADTFAKMLFGYGLLQLL 243
Cdd:COG1275 164 PLLELSYAFFGVGLFLYLVLLPLVLYRLIFHKPLPEALRPTLWILLAPPAVGLLAYLALGGGPLDGFALILWGFGLWWLL 243
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 635780967 244 FMLRLMPWYLSQPFNASFWSFSFGVSALATTGLHLGQSSPTGFFHAIAVPLFIFTNAIIGW 304
Cdd:COG1275 244 LLLLLTPRLLRLPFSPSWWAFTFPLAAYATATLRLAEATGLPFLAVLALALLVLATLVWLY 304
|
|
| SLAC1 |
pfam03595 |
Voltage-dependent anion channel; This family of transporters has ten alpha helical ... |
12-301 |
4.31e-34 |
|
Voltage-dependent anion channel; This family of transporters has ten alpha helical transmembrane segments. The structure of a bacterial homolog of SLAC1 shows it to have a trimeric arrangement. The pore is composed of five helices with a conserved Phe residue involved in gating. One homolog, Mae1 from the yeast Schizosaccharomyces pombe, functions as a malate uptake transporter; another, Ssu1 from Saccharomyces cerevisiae and other fungi including Aspergillus fumigatus, is characterized as a sulfite efflux pump; and TehA from Escherichia coli is identified as a tellurite resistance protein by virtue of its association in the tehA/tehB operon. In plants, this family is found in the stomatal guard cells functioning as an anion-transporting pore. Many homologs are incorrectly annotated as tellurite resistance or dicarboxylate transporter (TDT) proteins.
Pssm-ID: 460983 Cd Length: 321 Bit Score: 127.35 E-value: 4.31e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 12 NLPAGYFGMVLGIIGMGFAWRYAStLWPVTRWPGEGLVALAVICWFLLTVAFVTRAIRFPRSVLAEMRHPVMSSFVSLFP 91
Cdd:pfam03595 1 HFTPAWFAIVMGTGGLALLLHHLP-YGRGLRTIGLILFILNLVLFLLLLLLYLLRFILYPEAVRAELRHPVESLFLGTFP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 92 ATTMLVAIGFV------PWFRAVSLALFG-IGVVVQLAYSAWQSAGLWRGKHPQEATTPGLYLPTVANNFISAMA----C 160
Cdd:pfam03595 80 MGFATIINGLVlvpvpgPWLVTLAWVLWWwIGVALALAFAVGVPFLLFTRHHLLEAMTPAWLLPVVPLMVVAALGallaA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 161 GALGFNDAGLVFLGAGVFSWLSLEPVILQRLRSAGELPSALRTSLGIQLAPALVACSAWFSVNGGQADTF---------- 230
Cdd:pfam03595 160 LLLPILVVSYLLWGLGLFLALVILAIYLYRLFTHGLPPAELRPSLFIPLGPPGQGALALLLLGGAAPTILpaltalagei 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 231 --------AKMLFGYGLLQLLFMLRLM---PWYLSQPFNASFWSFSFGVSALATTGLHLGQSSPTGFFHAIAVPLFIFTN 299
Cdd:pfam03595 240 lyvvalllALFLWGFGLWWFFIAALSVlsaLRRGGLPFNLGWWAFTFPLGAFALATIELGKALDSPFFRVLGTILSVLLV 319
|
..
gi 635780967 300 AI 301
Cdd:pfam03595 320 LV 321
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10764 |
PRK10764 |
potassium-tellurite ethidium and proflavin transporter; Provisional |
5-304 |
3.52e-163 |
|
potassium-tellurite ethidium and proflavin transporter; Provisional
Pssm-ID: 236756 Cd Length: 324 Bit Score: 457.87 E-value: 3.52e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 5 NKPQQVLNLPAGYFGMVLGIIGMGFAWRYASTLWPVTRWPGEGLVALAVICWFLLTVAFVTRAIRFPRSVLAEMRHPVMS 84
Cdd:PRK10764 1 MQSDKVLPLPAGYFGIVLGLIGLGFAWRYAAQLWPLPAWIGEALVALASIIWALLILAYLYKWIRFPESVLAELRHPVQS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 85 SFVSLFPATTMLVAIGFVPWFRAVSLALFGIGVVVQLAYSAWQSAGLWRGKHPQEATTPGLYLPTVANNFISAMACGALG 164
Cdd:PRK10764 81 SFVSLIPITTMLVAIGLVPYSRPLAVVLFSFGVVGQLAFAAWRTAGLWRGGHPEEATTPGLYLPTVANNFVSAMALGALG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 165 FNDAGLVFLGAGVFSWLSLEPVILQRLRSAGELPSALRTSLGIQLAPALVACSAWFSVNGGQADTFAKMLFGYGLLQLLF 244
Cdd:PRK10764 161 YHDAGLLFLGAGVFSWLSLEPVILQRLRSSGELPTALRPSLGIQLAPAFVGCSAYLSVNGGEGDTLAKMLFGYGLLQLLF 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 245 MLRLMPWYLSQPFNASFWSFSFGVSALATTGLHLGQSSPTGFFHAIAVPLFIFTNAIIGW 304
Cdd:PRK10764 241 LLRLMPWILSQGFNASFWSFSFGVAALATTGLHLGHGSDNGFFHTLAVPLFIFANFIIAL 300
|
|
| TDT_TehA |
cd09324 |
Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; This ... |
14-304 |
1.10e-127 |
|
Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; This subfamily includes Tellurite resistance protein TehA that belongs to the C4-dicarboxylate transporter/malic acid transport (TDT) protein family and is a homolog of plant Slow Anion Channel-Associated 1 (SLAC1). The tehA gene encodes an integral membrane protein that has been shown to have efflux activity of quaternary ammonium compounds. TehA protein of Escherichia coli functions as a tellurite-resistance uptake permease.
Pssm-ID: 187764 Cd Length: 301 Bit Score: 366.98 E-value: 1.10e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 14 PAGYFGMVLGIIGMGFAWRYASTLWPVTRWPGEGLVALAVICWFLLTVAFVTRAIRFPRSVLAEMRHPVMSSFVSLFPAT 93
Cdd:cd09324 1 PVGYFGIVLGLAALGLAWRYAAQLWPLPAIVGESLLALASVVWLLLIGAYAYKWLKYREEARAELRHPVQCCFISLIPIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 94 TMLVAIGFVPWFRAVSLALFGIGVVVQLAYSAWQSAGLWRGKHPQEATTPGLYLPTVANNFISAMACGALGFNDAGLVFL 173
Cdd:cd09324 81 TMLVGIALYPYSRLLAEVLIVLGIIGQLAFAAWRTGGLWQGGHFPEATTPVLYLPTVAGNFVSASALAALGYHDLGMLFF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 174 GAGVFSWLSLEPVILQRLRSAGELPSALRTSLGIQLAPALVACSAWFSVNGGQADTFAKMLFGYGLLQLLFMLRLMPWYL 253
Cdd:cd09324 161 GAGMFSWLSLEPVILQRLRTSPPLPPALRPTLGIQLAPAFVGCSAYLSLNGGEVDLLAKMLWGYGLLQLLFLLRLLPWIA 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 635780967 254 SQPFNASFWSFSFGVSALATTGLHLGQSSPTGFFHAIAVPLFIFTNAIIGW 304
Cdd:cd09324 241 EQGFSMGFWAFSFGLAAMATSGLHLYHGGVLGPLSLLALALFNVANGLIAL 291
|
|
| tdt |
TIGR00816 |
C4-dicarboxylate transporter/malic acid transport protein; The Tellurite-Resistance ... |
13-303 |
4.93e-83 |
|
C4-dicarboxylate transporter/malic acid transport protein; The Tellurite-Resistance/Dicarboxylate Transporter (TDT) Family (TC 2.A.16)Two members of the TDT family have been functionally characterized. One is the TehA protein of E. coli which has been implicated in resistance to tellurite; the other is the Mae1 protein of S. pombe which functions in the uptake of malate and other dicarboxylates by a proton symportmechanism. These proteins exhibit 10 putative transmembrane a-helicalspanners (TMSs). [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273285 Cd Length: 320 Bit Score: 254.25 E-value: 4.93e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 13 LPAGYFGMVLGIIGMGFAWRYASTLWPVTRWPGEGLVALAVICWFLLTVAFVTRAIRFPRSVLAEMRHPVMSSFVSLFPA 92
Cdd:TIGR00816 1 FPWGWFAIVLGTGGLALASLSYSFYLPILKDLSDVLFILAIALFFLFTSCWLARLIRYPSNVLAELKHPVLSSFIPLIPI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 93 TTMLVAIGFVPWFRAVSLALFGIGVVVQLAYSAWQSAGLWRG-KHPQEATTPGLYLPTVANNFISAMACGALGFNDAGL- 170
Cdd:TIGR00816 81 STMLLGIDFIIWGYPLALGLWYIGAIGQLLFSVIVPFYLFKNeSIEIEHTHPGWYLPPVALIFISAAALAILPYLTHELt 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 171 ----VFLGAGVFSWLSLEPVILQRLRSAGELPSALRTSLGIQLAPALVACSAWFS-VNGGQADT-------FAKMLFGYG 238
Cdd:TIGR00816 161 vlfyFGWGAGFFLYLSLEAVLLLRLRLHGLLPSALRPTMFINLAPIGVGIVALINiVNHGEFITikepfliLAIILWGFG 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 635780967 239 LLQLLFMLRLMPWYLSQ--PFNASFWSFSFGVSALATTGLHLGQSSPTGFFHAIAVPLFIFTNAIIG 303
Cdd:TIGR00816 241 LWQLLFAIRLLLWYVKLklPFAMGWWAFIFPLAAYANSTHLVYKGFDFKVFQYIGFGLYVFLNFFWA 307
|
|
| TehA |
COG1275 |
Tellurite resistance protein TehA and related permeases [Defense mechanisms]; |
5-304 |
1.52e-79 |
|
Tellurite resistance protein TehA and related permeases [Defense mechanisms];
Pssm-ID: 440886 Cd Length: 323 Bit Score: 245.15 E-value: 1.52e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 5 NKPQQVLNLPAGYFGMVLGIIGMGFAWRYASTLWPVTRWPGEGLVALAVICWFLLTVAFVTRAIRFPRSVLAEMRHPVMS 84
Cdd:COG1275 4 APRSRLRNLPPAWFALVMGTGGLGLAWRLAAALLPGPAAIAEVLLALAALLFLVLLLLYLLKWLRYPAAVRADLRHPVRG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 85 SFVSLFPATTMLVAIGFVPWFRAVSLALFGIGVVVQLAYSAWQSAGLWRG-KHPQEATTPGLYLPTVANNFISAMACGAL 163
Cdd:COG1275 84 SFFPTIPMALLLLGTGLLPLAPALALVLWLLGVALHLALTVYFPYRLFTGeKFEIEHITPAWFIPVVGNIVVAVAGALLG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 164 GFNDAGLVFLGAGVFSWLSLEPVILQRLRSAGELPSALRTSLGIQLAPALVACSAWFSVNGGQADTFAKMLFGYGLLQLL 243
Cdd:COG1275 164 PLLELSYAFFGVGLFLYLVLLPLVLYRLIFHKPLPEALRPTLWILLAPPAVGLLAYLALGGGPLDGFALILWGFGLWWLL 243
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 635780967 244 FMLRLMPWYLSQPFNASFWSFSFGVSALATTGLHLGQSSPTGFFHAIAVPLFIFTNAIIGW 304
Cdd:COG1275 244 LLLLLTPRLLRLPFSPSWWAFTFPLAAYATATLRLAEATGLPFLAVLALALLVLATLVWLY 304
|
|
| TDT_TehA_like |
cd09322 |
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA proteins; The ... |
17-304 |
4.33e-75 |
|
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA proteins; The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane a-helical spanners (TMSs).
Pssm-ID: 187762 Cd Length: 289 Bit Score: 232.82 E-value: 4.33e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 17 YFGMVLGIIGMGFAWRYASTLWPVTRWPGEGLVALAVICWFLLTVAFVTRAIRFPRSVLAEMRHPVMSSFVSLFPATTML 96
Cdd:cd09322 1 LFPIVLGLLGLGLAWLGALLLLGLPSIVGEILGILALLLWLLLLLKYLLKLLRYPEAVKAELRHPVRASFFATFSMSLML 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 97 VAIGFVPWFRAVSLALFGIGVVVQLAYSAWQSAGLWRGKHPQEATTPGLYLPTVANNFISAMACgALGFNDAGLVFLGAG 176
Cdd:cd09322 81 LSIYLLPYSPLLARVLWILGAVLHLVFTLYFVSRWIRGGKFLEHVTPSWFIPYVGNIVVPVTGP-ALGGPELGWFFFGVG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 177 VFSWLSLEPVILQRLRSAGELPSALRTSLGIQLAPALVACSAWFSVNGGQADTFAKMLFGYGLLQLLFMLRLMPWYLSQP 256
Cdd:cd09322 160 LIFWLVLLPLVLYRLIFHEPLPEPLRPTLAILLAPPSLGLAAYLALFGGPIDLFALILLGLALFLFLLLLRLLPRLLKLP 239
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 635780967 257 FNASFWSFSFGVSALATTGLHLGQSSPTGFFHAIAVPLFIFTNAIIGW 304
Cdd:cd09322 240 FSPSWWAFTFPLAALAIALLKMAAYLGSGFLQLLALVLLELLTAVILV 287
|
|
| TDT_SLAC1_like |
cd09323 |
Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion ... |
12-304 |
4.43e-50 |
|
Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); SLAC1 (Slow Anion Channel-Associated 1) is a plasma membrane protein, preferentially expressed in guard cells, which encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. It is essential for stomatal closure in response to carbon dioxide, abscisic acid, ozone, light/dark transitions, humidity change, calcium ions, hydrogen peroxide and nitric oxide. In the Arabidopsis genome, SLAC1 is part of a gene family with five members and encodes a membrane protein that has ten putative transmembrane domains flanked by large N- and C-terminal domains. Mutations in SLAC1 impair slow (S-type) anion channel currents that are activated by cytosolic calcium ions and abscisic acid, but do not affect rapid (R-type) anion channel currents or calcium ion channel function.
Pssm-ID: 187763 Cd Length: 297 Bit Score: 168.49 E-value: 4.43e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 12 NLPAGYFGMVLGIIGMGFAWRYASTLWPVTRWPGEGLVALAVICWFLLTVAFVTRAIRFPRSVLAEMRHPVMSSFVSLFP 91
Cdd:cd09323 1 HFPVSLFAIVMGLSGLALAWRKAAELLGLPAAISEALGWLAVAVFVVLAALYALKILRYPEAVKAEFNHPVRINFFPAIS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 92 ATTMLVAIGFVPWFRAVSLALFGIGVVVQLAYSAWQSAGLWRGKHPQEAT-TPGLYLPTVAnNFISAMACGALGFNDAGL 170
Cdd:cd09323 81 ISLLLLSIALLPYSPVLALALWIIGAVLQLALTLYVVSRWISHRQFQIGHaNPAWFIPVVG-NLVVPIAGVPLGYAEVSW 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 171 VFLGAGVFSWLSLEPVILQRLRSAGELPSALRTSLGIQLAPALVACSAWFSVNgGQADTFAKMLFGYGLLQLLFMLRLMP 250
Cdd:cd09323 160 FFFSVGLFFWLVLFTIVFNRLIFHEPLPAKLLPTLFILIAPPAVGFLAYLKLT-GSLDAFARILYYIALFLFLLLLFQVR 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 635780967 251 WYLSQPFNASFWSFSFGVSALATTGLHLGQSSPTGFFHAIAVPLFIFTNAIIGW 304
Cdd:cd09323 239 RFRKLPFFLSWWAYSFPLAALAIATLRMAELTGSLFLQVLALVLLALLTLVVAV 292
|
|
| SLAC1 |
pfam03595 |
Voltage-dependent anion channel; This family of transporters has ten alpha helical ... |
12-301 |
4.31e-34 |
|
Voltage-dependent anion channel; This family of transporters has ten alpha helical transmembrane segments. The structure of a bacterial homolog of SLAC1 shows it to have a trimeric arrangement. The pore is composed of five helices with a conserved Phe residue involved in gating. One homolog, Mae1 from the yeast Schizosaccharomyces pombe, functions as a malate uptake transporter; another, Ssu1 from Saccharomyces cerevisiae and other fungi including Aspergillus fumigatus, is characterized as a sulfite efflux pump; and TehA from Escherichia coli is identified as a tellurite resistance protein by virtue of its association in the tehA/tehB operon. In plants, this family is found in the stomatal guard cells functioning as an anion-transporting pore. Many homologs are incorrectly annotated as tellurite resistance or dicarboxylate transporter (TDT) proteins.
Pssm-ID: 460983 Cd Length: 321 Bit Score: 127.35 E-value: 4.31e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 12 NLPAGYFGMVLGIIGMGFAWRYAStLWPVTRWPGEGLVALAVICWFLLTVAFVTRAIRFPRSVLAEMRHPVMSSFVSLFP 91
Cdd:pfam03595 1 HFTPAWFAIVMGTGGLALLLHHLP-YGRGLRTIGLILFILNLVLFLLLLLLYLLRFILYPEAVRAELRHPVESLFLGTFP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 92 ATTMLVAIGFV------PWFRAVSLALFG-IGVVVQLAYSAWQSAGLWRGKHPQEATTPGLYLPTVANNFISAMA----C 160
Cdd:pfam03595 80 MGFATIINGLVlvpvpgPWLVTLAWVLWWwIGVALALAFAVGVPFLLFTRHHLLEAMTPAWLLPVVPLMVVAALGallaA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 161 GALGFNDAGLVFLGAGVFSWLSLEPVILQRLRSAGELPSALRTSLGIQLAPALVACSAWFSVNGGQADTF---------- 230
Cdd:pfam03595 160 LLLPILVVSYLLWGLGLFLALVILAIYLYRLFTHGLPPAELRPSLFIPLGPPGQGALALLLLGGAAPTILpaltalagei 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 231 --------AKMLFGYGLLQLLFMLRLM---PWYLSQPFNASFWSFSFGVSALATTGLHLGQSSPTGFFHAIAVPLFIFTN 299
Cdd:pfam03595 240 lyvvalllALFLWGFGLWWFFIAALSVlsaLRRGGLPFNLGWWAFTFPLGAFALATIELGKALDSPFFRVLGTILSVLLV 319
|
..
gi 635780967 300 AI 301
Cdd:pfam03595 320 LV 321
|
|
| TDT_like_3 |
cd09321 |
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance ... |
16-297 |
5.73e-18 |
|
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane a-helical spanners (TMSs).
Pssm-ID: 187761 Cd Length: 327 Bit Score: 83.12 E-value: 5.73e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 16 GYFGMVLGIIGMGFAWRYASTLWPVTRWPGEGLVALAVICWFLLTVAFVTRAIRFPRSVLAEMRHPVMSSFVSLFPATTM 95
Cdd:cd09321 4 SWFASVMGTGALAIASYLYSAYFPFLKTLAVFLTYLNFLLFFVLLVPWLLRWILYPKEALADLKHPVLSNFYPTMPIALL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 96 LVA-----IGFVPWFRAVSLALFGIGVVVQLAYSAWQSAGLWRGKH-PQEATTPGLYLPTVAN-------NFISAMACGA 162
Cdd:cd09321 84 VLAtniliVGQGPLGYSLALTLWILGSILIFIFSFIVSYIMFINEEiPIEHINPAWFIPPVGLiviplagNFLIPHFPGA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 163 LG--FNDAGLVFLGAGVFSWLSLEPVILQRLRSAGELPSALRTSLGIQLAPALVACSAWFS-VNGGQADT---------- 229
Cdd:cd09321 164 WQesILVINLFGFGIGFFLFLFLLAIILHRLILHEPPPPELAPTFWINLAPIGAGVVALINlVKALPFAGlenlvdlani 243
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 635780967 230 FAKMLFGYGLLQLLFMLRLMPWYLSQ---PFNASFWSFSFGVSALATTGLHLGQSSPTGFFHAIAVPLFIF 297
Cdd:cd09321 244 FALILWGFGLWWLILAVLLTLYYLKRgnlPFSLGWWAFIFPLGAYTIATYLVAKVLNFSFLSGLGIFLYWL 314
|
|
| TDT |
cd09299 |
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance ... |
17-302 |
1.05e-15 |
|
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane alpha-helical spanners (TMSs).
Pssm-ID: 187756 Cd Length: 326 Bit Score: 76.60 E-value: 1.05e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 17 YFGMVLGIIGMGFAWRYASTLWPVTRWPGEGLVALAVICWFLLTVAFVTRAIRFPRSVLAEMRH-PVMSSFVSLFPATTM 95
Cdd:cd09299 1 WFGIVMGTGILSLALYLLPYQFPGLRIIGKILFILAIVIFILFFALWLLRLIRYPRHVVRESHHnPVEASFLAAVPISLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 96 LVAIGFVPWFRA--------VSLALFGIGVVVQLAYSAWQSAGLWRGKHP-QEATTPGLYLPTVANNFISAMA------- 159
Cdd:cd09299 81 TIIDFLALYGGAntgrlvilIAYVLWWIGLALSLVSAVGVPYLLFTNHVYeIEHISPAWLLPIVPPMTSAALAgallpys 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 160 ---CGALGFNDAGLVFLGAGVFSWLSLEPVILQRLRSAGELPSALRTSLGIQLAPALVACSAWFSVNGGQ---------- 226
Cdd:cd09299 161 pggAIQLSVIFLGYLFFGIGFFLFIFIGAIIFSRLVINKLPPGQLAPTLMIVLGPMGQSIFALLLLGKNArlifflyasf 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 227 ----ADTFAKMLFGYGLLQLLFMLRLMPWYL--SQPFNASFWSFSF--GVSALATTGLHLGQSSPtgFFHAIAVPLFIFT 298
Cdd:cd09299 241 lqalAVFASIILWGFGLWWLLLALVSILRTLrkKLPFSLGWWSYVFplGVYTNGTYALYKLMDLP--AFSIFATILLIIL 318
|
....
gi 635780967 299 NAII 302
Cdd:cd09299 319 VALW 322
|
|
| TDT_C4-dicarb_trans |
cd09325 |
C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) ... |
12-304 |
1.06e-11 |
|
C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; This subfamily contains bacterial C4-dicarboxylate transporters, which is part of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family. It includes Tellurite resistance protein tehA; the tehA gene encodes an integral membrane protein that has been shown to have efflux activity of quaternary ammonium compounds. TehA protein of Escherichia coli functions as a tellurite-resistance uptake permease.
Pssm-ID: 187765 Cd Length: 293 Bit Score: 64.49 E-value: 1.06e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 12 NLPAGYFGMVLGIIGMGfaWRYASTLWPVTRWPGEGLvalAVICWFLLTVAFvtraIRFPRSVLAEMRHPVMSSFVSLFP 91
Cdd:cd09325 1 KIPIPIAGLALGLASLG--NLLELSYGSILRNICGLI---ALILLILLLLKI----ILFPKTLKEELKNPVIASVFPTFP 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 92 ATTMLVAIGFVPWFRAVSLALFGIGVVVQL---AYSAWQSAGLWRGKHPqeatTPGLYLPTVAnNFISAMACGALGFNDA 168
Cdd:cd09325 72 MALMLLSTYLKPFFPALAQLLWLLAIILHIiliIYFTYKRILKFNLEHV----FPSWFVVYVG-IVVASVTAPAFGQPLL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 169 GLVFLGAGVFSWLSLEPVILQRLRSAGELPSALRTSLGIQLAPAlVACSAWFSVNGGQADT-FAKMLFGYGLLQLLFMLR 247
Cdd:cd09325 147 GQIAFWFGFVAYLILLPLVLYRLVKIKELPDAALPTIAIFAAPA-SLCLAGYLNSFPEPNPvLVLFLLILSQLLYFFVLL 225
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 635780967 248 LMPWYLSQPFNASFWSFSF-----GVSALATTGLHLGQSSPTGFFHAIAVPLFIFTNAIIGW 304
Cdd:cd09325 226 QLPRLLKLPFYPSFAAFTFplvisATALKKTSTYLASYGLYLPILKYLALFEILIATVIVLY 287
|
|
| TDT_SSU1 |
cd09318 |
Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity ... |
42-151 |
4.71e-04 |
|
Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); This family contains the sulfite sensitivity protein (sulfite efflux pump; SSU1) and belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family. The SSU1 gene encodes the sulfite pump required for efficient sulfite efflux. Mutations in the SSU1 gene cause sensitivity to sulfite while overexpression confers heightened resistance to sulfite toxicity. In dematophytes and other filamentous fungi, sulfite is excreted as a reducing agent during keratin degradation; thus sulfite transporters in keratinolytic fungi could be a new target for antifungal drugs in dermatology. The number of genes encoding sulfite efflux pumps in fungal genomes varies from species to species.
Pssm-ID: 187758 Cd Length: 341 Bit Score: 41.41 E-value: 4.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 42 RWPGEGLVALAVICWFLLTVAFVTRAIRFPRSVLAEMRHPVMSSFVSLFP---ATT-----MLVAIGFVPWFRAVSLALF 113
Cdd:cd09318 34 RIIGYILFGINVLLFILFTVLFIARYVLYPERFRAMLKHPTQSLFLGTIPmglATIingivLLCGPVWGPWAIILAWVLW 113
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 635780967 114 GIGVVVQLA------YSAWQSaglwRGKHPQEATTPGLYLPTVA 151
Cdd:cd09318 114 WIDVALSLAtawgvpFLMFTR----QNKHALEKMTAVWLLPIVA 153
|
|
| TDT_like_2 |
cd09320 |
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance ... |
39-297 |
7.62e-03 |
|
The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; The Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes members from all three kingdoms, but only three members of the family have been functionally characterized: the TehA protein of E. coli functioning as a tellurite-resistance uptake permease, the Mae1 protein of S. pombe functioning in the uptake of malate and other dicarboxylates, and the sulfite efflux pump (SSU1) of Saccharomyces cerevisiae. In plants, the plasma membrane protein SLAC1 (Slow Anion Channel-Associated 1), which is preferentially expressed in guard cells, encodes a distant homolog of fungal and bacterial dicarboxylate/malic acid transport proteins. SLAC1 is essential in mediating stomatal responses to physiological and stress stimuli. Members of the TDT family exhibit 10 putative transmembrane alpha-helical spanners (TMSs).
Pssm-ID: 187760 Cd Length: 327 Bit Score: 37.69 E-value: 7.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 39 PVTRWPGEGLVALAVICWFLLTVAFVTRAIRFPRsvLAEMRHPVMSSFVSLFP---------ATTMLVAIGFVPWFRAVS 109
Cdd:cd09320 25 PGLRTGAEAFWLVAALLLVALTAGFAAHWRRHPA--FARARDPVMMPFWGMVSmgllavgaaTLTVGPDVIGHDAAVAVD 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 110 LALFGIGVVVQLAYSAWQSAGLwrGKHPQEATTPGLYLP--------TVANNFISAMACGALGFN--DAGLVFLGAGVFS 179
Cdd:cd09320 103 TVLWVIGTVLGLVTAVVIPRRL--IRRHRGTPTPVWGLPvvppmvsaTTGAQLVPHLPAGQPRLTllLACYACFGLSLLA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635780967 180 WLSLEPVILQRLRSAGELPSALRTSLGIQL--------APALVACSAWFSVNGGQADTFAKMLFGYGLLQLLFMLRLMPW 251
Cdd:cd09320 181 AAIIFALVYRRLWRGGPLPLAAAPTAWIPLgvvgqstaAAQLLAAAAGHVLPPPTAQTLHVFAVLYGVVMLGFGVPLLAL 260
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 635780967 252 YLSQ---------PFNASFWSFSFGVSALATTGLHLGQSSPTGFFHAIAVPLFIF 297
Cdd:cd09320 261 AAAVtvravrrgmPFSPTWWAFTFPVGTCVLGAHALAVHTGLAWFDWLAAALLVL 315
|
|
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