hypothetical protein AF41_02996 [Citrobacter sp. MGH 55]
GntR family transcriptional regulator( domain architecture ID 11450764)
GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
MngR | COG2188 | DNA-binding transcriptional regulator, GntR family [Transcription]; |
20-245 | 4.79e-66 | ||||
DNA-binding transcriptional regulator, GntR family [Transcription]; : Pssm-ID: 441791 [Multi-domain] Cd Length: 238 Bit Score: 204.71 E-value: 4.79e-66
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Name | Accession | Description | Interval | E-value | ||||
MngR | COG2188 | DNA-binding transcriptional regulator, GntR family [Transcription]; |
20-245 | 4.79e-66 | ||||
DNA-binding transcriptional regulator, GntR family [Transcription]; Pssm-ID: 441791 [Multi-domain] Cd Length: 238 Bit Score: 204.71 E-value: 4.79e-66
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PRK11402 | PRK11402 | transcriptional regulator PhoB; |
22-244 | 4.58e-39 | ||||
transcriptional regulator PhoB; Pssm-ID: 183118 [Multi-domain] Cd Length: 241 Bit Score: 135.73 E-value: 4.58e-39
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UTRA | pfam07702 | UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ... |
108-242 | 3.02e-37 | ||||
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). Pssm-ID: 429607 [Multi-domain] Cd Length: 141 Bit Score: 127.71 E-value: 3.02e-37
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UTRA | smart00866 | The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ... |
108-242 | 1.94e-32 | ||||
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules. Pssm-ID: 214869 [Multi-domain] Cd Length: 143 Bit Score: 115.47 E-value: 1.94e-32
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C_P_lyase_phnF | TIGR02325 | phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ... |
24-247 | 2.25e-28 | ||||
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions] Pssm-ID: 131378 [Multi-domain] Cd Length: 238 Bit Score: 107.56 E-value: 2.25e-28
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WHTH_GntR | cd07377 | Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ... |
23-88 | 6.84e-18 | ||||
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences. Pssm-ID: 153418 [Multi-domain] Cd Length: 66 Bit Score: 75.18 E-value: 6.84e-18
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Name | Accession | Description | Interval | E-value | ||||
MngR | COG2188 | DNA-binding transcriptional regulator, GntR family [Transcription]; |
20-245 | 4.79e-66 | ||||
DNA-binding transcriptional regulator, GntR family [Transcription]; Pssm-ID: 441791 [Multi-domain] Cd Length: 238 Bit Score: 204.71 E-value: 4.79e-66
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PRK11402 | PRK11402 | transcriptional regulator PhoB; |
22-244 | 4.58e-39 | ||||
transcriptional regulator PhoB; Pssm-ID: 183118 [Multi-domain] Cd Length: 241 Bit Score: 135.73 E-value: 4.58e-39
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UTRA | pfam07702 | UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ... |
108-242 | 3.02e-37 | ||||
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). Pssm-ID: 429607 [Multi-domain] Cd Length: 141 Bit Score: 127.71 E-value: 3.02e-37
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UTRA | smart00866 | The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ... |
108-242 | 1.94e-32 | ||||
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules. Pssm-ID: 214869 [Multi-domain] Cd Length: 143 Bit Score: 115.47 E-value: 1.94e-32
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C_P_lyase_phnF | TIGR02325 | phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ... |
24-247 | 2.25e-28 | ||||
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions] Pssm-ID: 131378 [Multi-domain] Cd Length: 238 Bit Score: 107.56 E-value: 2.25e-28
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PRK09764 | PRK09764 | GntR family transcriptional regulator; |
21-244 | 1.81e-22 | ||||
GntR family transcriptional regulator; Pssm-ID: 182065 [Multi-domain] Cd Length: 240 Bit Score: 92.20 E-value: 1.81e-22
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WHTH_GntR | cd07377 | Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ... |
23-88 | 6.84e-18 | ||||
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences. Pssm-ID: 153418 [Multi-domain] Cd Length: 66 Bit Score: 75.18 E-value: 6.84e-18
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PRK10079 | PRK10079 | phosphonate metabolism transcriptional regulator PhnF; Provisional |
44-247 | 3.19e-15 | ||||
phosphonate metabolism transcriptional regulator PhnF; Provisional Pssm-ID: 182227 [Multi-domain] Cd Length: 241 Bit Score: 72.50 E-value: 3.19e-15
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HTH_GNTR | smart00345 | helix_turn_helix gluconate operon transcriptional repressor; |
29-87 | 1.01e-13 | ||||
helix_turn_helix gluconate operon transcriptional repressor; Pssm-ID: 197669 [Multi-domain] Cd Length: 60 Bit Score: 63.75 E-value: 1.01e-13
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GntR | pfam00392 | Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ... |
24-85 | 3.12e-13 | ||||
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor. Pssm-ID: 306822 [Multi-domain] Cd Length: 64 Bit Score: 62.63 E-value: 3.12e-13
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FadR | COG2186 | DNA-binding transcriptional regulator, FadR family [Transcription]; |
17-89 | 7.26e-13 | ||||
DNA-binding transcriptional regulator, FadR family [Transcription]; Pssm-ID: 441789 [Multi-domain] Cd Length: 232 Bit Score: 65.73 E-value: 7.26e-13
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ARO8 | COG1167 | DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ... |
15-85 | 2.08e-12 | ||||
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis Pssm-ID: 440781 [Multi-domain] Cd Length: 471 Bit Score: 66.01 E-value: 2.08e-12
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YhcF | COG1725 | DNA-binding transcriptional regulator YhcF, GntR family [Transcription]; |
15-85 | 2.29e-12 | ||||
DNA-binding transcriptional regulator YhcF, GntR family [Transcription]; Pssm-ID: 441331 [Multi-domain] Cd Length: 114 Bit Score: 61.73 E-value: 2.29e-12
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PRK04984 | PRK04984 | fatty acid metabolism transcriptional regulator FadR; |
28-94 | 2.07e-08 | ||||
fatty acid metabolism transcriptional regulator FadR; Pssm-ID: 179909 [Multi-domain] Cd Length: 239 Bit Score: 53.34 E-value: 2.07e-08
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PRK03837 | PRK03837 | transcriptional regulator NanR; Provisional |
27-81 | 3.13e-07 | ||||
transcriptional regulator NanR; Provisional Pssm-ID: 235166 [Multi-domain] Cd Length: 241 Bit Score: 49.64 E-value: 3.13e-07
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GntR | COG1802 | DNA-binding transcriptional regulator, GntR family [Transcription]; |
41-99 | 4.24e-07 | ||||
DNA-binding transcriptional regulator, GntR family [Transcription]; Pssm-ID: 441407 [Multi-domain] Cd Length: 222 Bit Score: 49.15 E-value: 4.24e-07
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PRK14999 | PRK14999 | histidine utilization repressor; Provisional |
23-168 | 1.18e-06 | ||||
histidine utilization repressor; Provisional Pssm-ID: 184961 [Multi-domain] Cd Length: 241 Bit Score: 48.01 E-value: 1.18e-06
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pdhR | PRK09464 | pyruvate dehydrogenase complex transcriptional repressor PdhR; |
39-89 | 1.74e-05 | ||||
pyruvate dehydrogenase complex transcriptional repressor PdhR; Pssm-ID: 181879 [Multi-domain] Cd Length: 254 Bit Score: 44.63 E-value: 1.74e-05
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PRK10421 | PRK10421 | DNA-binding transcriptional repressor LldR; Provisional |
44-87 | 1.86e-05 | ||||
DNA-binding transcriptional repressor LldR; Provisional Pssm-ID: 236690 [Multi-domain] Cd Length: 253 Bit Score: 44.76 E-value: 1.86e-05
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PRK11523 | PRK11523 | transcriptional regulator ExuR; |
24-87 | 4.25e-05 | ||||
transcriptional regulator ExuR; Pssm-ID: 183176 [Multi-domain] Cd Length: 253 Bit Score: 43.68 E-value: 4.25e-05
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BirA | COG1654 | Biotin operon repressor [Transcription]; |
42-83 | 1.66e-04 | ||||
Biotin operon repressor [Transcription]; Pssm-ID: 441260 [Multi-domain] Cd Length: 324 Bit Score: 41.90 E-value: 1.66e-04
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PRK09990 | PRK09990 | DNA-binding transcriptional regulator GlcC; Provisional |
29-148 | 1.78e-04 | ||||
DNA-binding transcriptional regulator GlcC; Provisional Pssm-ID: 182186 [Multi-domain] Cd Length: 251 Bit Score: 41.68 E-value: 1.78e-04
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GlpR | COG1349 | DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ... |
52-82 | 4.69e-04 | ||||
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism]; Pssm-ID: 440960 [Multi-domain] Cd Length: 254 Bit Score: 40.50 E-value: 4.69e-04
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PRK10225 | PRK10225 | Uxu operon transcriptional regulator; |
44-84 | 7.46e-04 | ||||
Uxu operon transcriptional regulator; Pssm-ID: 182318 [Multi-domain] Cd Length: 257 Bit Score: 40.00 E-value: 7.46e-04
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HTH_CRP | smart00419 | helix_turn_helix, cAMP Regulatory protein; |
51-83 | 9.94e-04 | ||||
helix_turn_helix, cAMP Regulatory protein; Pssm-ID: 128696 [Multi-domain] Cd Length: 48 Bit Score: 36.26 E-value: 9.94e-04
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HTH_DEOR | smart00420 | helix_turn_helix, Deoxyribose operon repressor; |
52-82 | 1.19e-03 | ||||
helix_turn_helix, Deoxyribose operon repressor; Pssm-ID: 197714 [Multi-domain] Cd Length: 53 Bit Score: 36.05 E-value: 1.19e-03
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HTH_11 | pfam08279 | HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins. |
52-83 | 2.41e-03 | ||||
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins. Pssm-ID: 429896 [Multi-domain] Cd Length: 52 Bit Score: 35.10 E-value: 2.41e-03
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Lrp | COG1522 | DNA-binding transcriptional regulator, Lrp family [Transcription]; |
51-88 | 3.28e-03 | ||||
DNA-binding transcriptional regulator, Lrp family [Transcription]; Pssm-ID: 441131 [Multi-domain] Cd Length: 138 Bit Score: 36.68 E-value: 3.28e-03
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COG3355 | COG3355 | Predicted transcriptional regulator [Transcription]; |
52-94 | 6.17e-03 | ||||
Predicted transcriptional regulator [Transcription]; Pssm-ID: 442583 [Multi-domain] Cd Length: 131 Bit Score: 35.71 E-value: 6.17e-03
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HTH_Crp_2 | pfam13545 | Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain ... |
51-81 | 6.20e-03 | ||||
Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain that is likely to bind DNA. Pssm-ID: 463917 [Multi-domain] Cd Length: 68 Bit Score: 34.35 E-value: 6.20e-03
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HTH_ICLR | smart00346 | helix_turn_helix isocitrate lyase regulation; |
39-84 | 8.32e-03 | ||||
helix_turn_helix isocitrate lyase regulation; Pssm-ID: 214629 [Multi-domain] Cd Length: 91 Bit Score: 34.87 E-value: 8.32e-03
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Blast search parameters | ||||
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