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Conserved domains on  [gi|2286982790|gb|KAI6539929|]
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hypothetical protein MCOR16_001139 [Pyricularia oryzae]

Protein Classification

HD domain-containing protein( domain architecture ID 10586555)

HD domain-containing protein may function as a metal dependent phosphohydrolase; similar to Homo sapiens 5'-deoxynucleotidase HDDC2, which catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP)

CATH:  3.30.70.1370
EC:  3.1.-.-
Gene Ontology:  GO:0042578|GO:0046872
PubMed:  9868367
SCOP:  3000943

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
HD_3 pfam13023
HD domain; HD domains are metal dependent phosphohydrolases.
 64-229 2.51e-71

HD domain; HD domains are metal dependent phosphohydrolases.


:

Pssm-ID: 432939  Cd Length: 163  Bit Score: 216.70  E-value: 2.51e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286982790  64 LERLKTTKREGWRRFGIERGESIADHMYRMSLMSMLAPPTLAPrLDLNKCIKMCLIHDMAESLVGDITPVDGVAKPEKAR 143
Cdd:pfam13023   1 ADKLKFVKRQGWLQDGRVRPESVAEHSWRMALMAMLLAEYAGP-VDIARVIKMALIHDLVEILAGDIIPYDGVAKEEKEE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286982790 144 REAATMDYITSTLLGNvygggntVGAEMRAIWQEYEDSETLESKYVHDIDKMELICQMVEYEKR--GEGRLDLGEFAWVA 221
Cdd:pfam13023  80 REREAAERIFGLLPED-------QGEELLALWDEFEARETPEAKFAKDLDKLEPLLQNLEYEGDswAAFEADLSQFYGRN 152


                  ....*...
gi 2286982790 222 KKMVLPEM 229
Cdd:pfam13023 153 STILAEGS 160
 
Name Accession Description Interval E-value
HD_3 pfam13023
HD domain; HD domains are metal dependent phosphohydrolases.
 64-229 2.51e-71

HD domain; HD domains are metal dependent phosphohydrolases.


Pssm-ID: 432939  Cd Length: 163  Bit Score: 216.70  E-value: 2.51e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286982790  64 LERLKTTKREGWRRFGIERGESIADHMYRMSLMSMLAPPTLAPrLDLNKCIKMCLIHDMAESLVGDITPVDGVAKPEKAR 143
Cdd:pfam13023   1 ADKLKFVKRQGWLQDGRVRPESVAEHSWRMALMAMLLAEYAGP-VDIARVIKMALIHDLVEILAGDIIPYDGVAKEEKEE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286982790 144 REAATMDYITSTLLGNvygggntVGAEMRAIWQEYEDSETLESKYVHDIDKMELICQMVEYEKR--GEGRLDLGEFAWVA 221
Cdd:pfam13023  80 REREAAERIFGLLPED-------QGEELLALWDEFEARETPEAKFAKDLDKLEPLLQNLEYEGDswAAFEADLSQFYGRN 152


                  ....*...
gi 2286982790 222 KKMVLPEM 229
Cdd:pfam13023 153 STILAEGS 160
YfbR COG1896
5'-deoxynucleotidase YfbR and related HD superfamily hydrolases [Nucleotide transport and ...
 58-208 2.05e-35

5'-deoxynucleotidase YfbR and related HD superfamily hydrolases [Nucleotide transport and metabolism, General function prediction only];


Pssm-ID: 441500  Cd Length: 162  Bit Score: 124.59  E-value: 2.05e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286982790  58 LPYFHLLERLKTTKREGWRRFGIErgESIADHMYRMSLMSMLAPPTLAPRLDLNKCIKMCLIHDMAESLVGDITPVDGVA 137
Cdd:COG1896     2 LDFLAELDRLKLIKRWGLLRNSRP--ENVAEHSWHVALIAHLLADIANEGVDPERVAKMALLHDLVEIDTGDIPTPVKYA 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2286982790 138 KPEKARREAATMDYITSTLlgnvyggGNTVGAEMRAIWQEYEDSETLESKYVHDIDKMELICQMVEYEKRG 208
Cdd:COG1896    80 NEAKKEIERAAAERLFGLL-------PEELREEFRALWDEFEAGETPEARFVKAADKLEALLQALEEIGAG 143
 
Name Accession Description Interval E-value
HD_3 pfam13023
HD domain; HD domains are metal dependent phosphohydrolases.
 64-229 2.51e-71

HD domain; HD domains are metal dependent phosphohydrolases.


Pssm-ID: 432939  Cd Length: 163  Bit Score: 216.70  E-value: 2.51e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286982790  64 LERLKTTKREGWRRFGIERGESIADHMYRMSLMSMLAPPTLAPrLDLNKCIKMCLIHDMAESLVGDITPVDGVAKPEKAR 143
Cdd:pfam13023   1 ADKLKFVKRQGWLQDGRVRPESVAEHSWRMALMAMLLAEYAGP-VDIARVIKMALIHDLVEILAGDIIPYDGVAKEEKEE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286982790 144 REAATMDYITSTLLGNvygggntVGAEMRAIWQEYEDSETLESKYVHDIDKMELICQMVEYEKR--GEGRLDLGEFAWVA 221
Cdd:pfam13023  80 REREAAERIFGLLPED-------QGEELLALWDEFEARETPEAKFAKDLDKLEPLLQNLEYEGDswAAFEADLSQFYGRN 152


                  ....*...
gi 2286982790 222 KKMVLPEM 229
Cdd:pfam13023 153 STILAEGS 160
YfbR COG1896
5'-deoxynucleotidase YfbR and related HD superfamily hydrolases [Nucleotide transport and ...
 58-208 2.05e-35

5'-deoxynucleotidase YfbR and related HD superfamily hydrolases [Nucleotide transport and metabolism, General function prediction only];


Pssm-ID: 441500  Cd Length: 162  Bit Score: 124.59  E-value: 2.05e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2286982790  58 LPYFHLLERLKTTKREGWRRFGIErgESIADHMYRMSLMSMLAPPTLAPRLDLNKCIKMCLIHDMAESLVGDITPVDGVA 137
Cdd:COG1896     2 LDFLAELDRLKLIKRWGLLRNSRP--ENVAEHSWHVALIAHLLADIANEGVDPERVAKMALLHDLVEIDTGDIPTPVKYA 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2286982790 138 KPEKARREAATMDYITSTLlgnvyggGNTVGAEMRAIWQEYEDSETLESKYVHDIDKMELICQMVEYEKRG 208
Cdd:COG1896    80 NEAKKEIERAAAERLFGLL-------PEELREEFRALWDEFEAGETPEARFVKAADKLEALLQALEEIGAG 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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