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Conserved domains on  [gi|2130399071|gb|KAH7613207|]
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UEV domain [[Candida] glabrata]

Protein Classification

UEV and Vps23_core domain-containing protein( domain architecture ID 10530391)

UEV and Vps23_core domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UEV pfam05743
UEV domain; This family includes the eukaryotic tumour susceptibility gene 101 protein (TSG101) ...
 27-145 7.87e-42

UEV domain; This family includes the eukaryotic tumour susceptibility gene 101 protein (TSG101). Altered transcripts of this gene have been detected in sporadic breast cancers and many other human malignancies. However, the involvement of this gene in neoplastic transformation and tumorigenesis is still elusive. TSG101 is required for normal cell function of embryonic and adult tissues but that this gene is not a tumour suppressor for sporadic forms of breast cancer. This family is related to the ubiquitin conjugating enzymes.


:

Pssm-ID: 399041  Cd Length: 119  Bit Score: 144.71  E-value: 7.87e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130399071  27 VFHDAVQTLTEFKNLRPRTRVFTDEDGSPRLLLCLYGGIHI-EQG--LDVPVLIWIPESYPIAKPLLFIDLEllgKDLQL 103
Cdd:pfam05743   1 TFKDLVNVLRKFPNLKPRTDVYTFNDGSSKLLLNLYGTIPVtYKGntYNIPILIWLPDTYPFSPPICYVKPT---ASMVI 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2130399071 104 ATNESVEPDGRVHTRLLRQWNPQSANLFNVIQDLADMCNAIA 145
Cdd:pfam05743  78 KVNHHVDAQGRVYLPYLHNWNHPSSNLVDLVQELAQVFQEDP 119
Vps23_core pfam09454
Vps23 core domain; ESCRT complexes form the main machinery driving protein sorting from ...
 398-457 5.81e-20

Vps23 core domain; ESCRT complexes form the main machinery driving protein sorting from endosomes to lysosomes. The core domain of the Vps23 subunit of the heterotrimeric ESCRT-I complex is a helical hairpin sandwiched in a fan-like formation between two other helical hairpins from Vps28 (pfam03997) and Vps37. Vps23 gives ESCRT-I complex its stability.


:

Pssm-ID: 462803 [Multi-domain]  Cd Length: 60  Bit Score: 83.28  E-value: 5.81e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130399071 398 TVYTTEVPALDQLYTLVARDRALTDTIQVLARLLNCGALEFDAFIKKVRELARDQFMARL 457
Cdd:pfam09454   1 EVVVATTPLSNQLLELVAEDKAIEDTIYLLDKALDRGVIDLDTFLKQVRELAREQFLKRA 60
 
Name Accession Description Interval E-value
UEV pfam05743
UEV domain; This family includes the eukaryotic tumour susceptibility gene 101 protein (TSG101) ...
 27-145 7.87e-42

UEV domain; This family includes the eukaryotic tumour susceptibility gene 101 protein (TSG101). Altered transcripts of this gene have been detected in sporadic breast cancers and many other human malignancies. However, the involvement of this gene in neoplastic transformation and tumorigenesis is still elusive. TSG101 is required for normal cell function of embryonic and adult tissues but that this gene is not a tumour suppressor for sporadic forms of breast cancer. This family is related to the ubiquitin conjugating enzymes.


Pssm-ID: 399041  Cd Length: 119  Bit Score: 144.71  E-value: 7.87e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130399071  27 VFHDAVQTLTEFKNLRPRTRVFTDEDGSPRLLLCLYGGIHI-EQG--LDVPVLIWIPESYPIAKPLLFIDLEllgKDLQL 103
Cdd:pfam05743   1 TFKDLVNVLRKFPNLKPRTDVYTFNDGSSKLLLNLYGTIPVtYKGntYNIPILIWLPDTYPFSPPICYVKPT---ASMVI 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2130399071 104 ATNESVEPDGRVHTRLLRQWNPQSANLFNVIQDLADMCNAIA 145
Cdd:pfam05743  78 KVNHHVDAQGRVYLPYLHNWNHPSSNLVDLVQELAQVFQEDP 119
UEV_TSG101-like cd11685
ubiquitin E2 variant (UEV) domain of TSG101 and related proteins; This subfamily includes the ...
 25-147 4.15e-28

ubiquitin E2 variant (UEV) domain of TSG101 and related proteins; This subfamily includes the UEV domain of eukaryotic tumor susceptibility gene 101 protein (TSG101, also known as ESCRT-I complex subunit TSG101, vacuolar protein-sorting protein 23, or Vps23) which functions in endocytic trafficking. TSG101 is a component of the ESCRT (endosomal sorting complex required for transport)-I complex, one of four complexes (ESCRT 0, -I, -II, -III) in the vacuolar protein sorting pathway. TSG101 also facilitates HIV-1 virus budding from infected cells, perhaps by linking the p6 domain of the viral structural Gag protein to the vacuolar protein sorting machinery. The UEV domain of TSG101 binds to an essential tetrapeptide motif within the p6 domain of the structural Gag protein and also to ubiquitin. UEVs are homologous to E2 ubiquitin ligases but lack the conserved cysteine residue required for catalytic activity.


Pssm-ID: 467408  Cd Length: 126  Bit Score: 108.16  E-value: 4.15e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130399071  25 KLVFHDAVQTLTEFKNLRPRTRVFTDEDGSPRLLLCLYGGIHI---EQGLDVPVLIWIPESYPIAKPLLFIDLEllGKDL 101
Cdd:cd11685     1 DRVREDLLNLLQKYPSLKPKTDTFTFNDGSSKLLLCLTGTIPItyrGSTYNIPITIWLPETYPYSPPIVYVVPT--PSMM 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2130399071 102 QLATNESVEPDGRVHTRLLRQWNPQSANLFNVIQDLADMCNAIAPI 147
Cdd:cd11685    79 IIKPHPHVDPNGRVYLPYLSEWNPPSSNLVDLVQELSAVFSEEPPV 124
Vps23_core pfam09454
Vps23 core domain; ESCRT complexes form the main machinery driving protein sorting from ...
 398-457 5.81e-20

Vps23 core domain; ESCRT complexes form the main machinery driving protein sorting from endosomes to lysosomes. The core domain of the Vps23 subunit of the heterotrimeric ESCRT-I complex is a helical hairpin sandwiched in a fan-like formation between two other helical hairpins from Vps28 (pfam03997) and Vps37. Vps23 gives ESCRT-I complex its stability.


Pssm-ID: 462803 [Multi-domain]  Cd Length: 60  Bit Score: 83.28  E-value: 5.81e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130399071 398 TVYTTEVPALDQLYTLVARDRALTDTIQVLARLLNCGALEFDAFIKKVRELARDQFMARL 457
Cdd:pfam09454   1 EVVVATTPLSNQLLELVAEDKAIEDTIYLLDKALDRGVIDLDTFLKQVRELAREQFLKRA 60
UBCc smart00212
Ubiquitin-conjugating enzyme E2, catalytic domain homologues; Proteins destined for ...
 12-149 2.95e-03

Ubiquitin-conjugating enzyme E2, catalytic domain homologues; Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. This pathway functions in regulating many fundamental processes required for cell viability.TSG101 is one of several UBC homologues that lacks this active site cysteine.


Pssm-ID: 214562 [Multi-domain]  Cd Length: 145  Bit Score: 38.04  E-value: 2.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130399071   12 WLFKVIQPIYKQPKLVFHDAVqtlTEFKNLRPRTRVFTDEDGSPrlllclY-GGIHieqgldvPVLIWIPESYPIAKPLL 90
Cdd:smart00212   1 RLLKELKELRKDPPPGFTAYP---VDDENLLEWTGTIVGPPGTP------YeGGVF-------KLTIEFPEDYPFKPPKV 64

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2130399071   91 FIDLELLgkdlqlatNESVEPDGRVHTRLLRQ--WNPQSaNLFNVIQDLADMCNAIAPIQP 149
Cdd:smart00212  65 KFITKIY--------HPNVDSSGEICLDILKQekWSPAL-TLETVLLSLQSLLSEPNPDSP 116
 
Name Accession Description Interval E-value
UEV pfam05743
UEV domain; This family includes the eukaryotic tumour susceptibility gene 101 protein (TSG101) ...
 27-145 7.87e-42

UEV domain; This family includes the eukaryotic tumour susceptibility gene 101 protein (TSG101). Altered transcripts of this gene have been detected in sporadic breast cancers and many other human malignancies. However, the involvement of this gene in neoplastic transformation and tumorigenesis is still elusive. TSG101 is required for normal cell function of embryonic and adult tissues but that this gene is not a tumour suppressor for sporadic forms of breast cancer. This family is related to the ubiquitin conjugating enzymes.


Pssm-ID: 399041  Cd Length: 119  Bit Score: 144.71  E-value: 7.87e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130399071  27 VFHDAVQTLTEFKNLRPRTRVFTDEDGSPRLLLCLYGGIHI-EQG--LDVPVLIWIPESYPIAKPLLFIDLEllgKDLQL 103
Cdd:pfam05743   1 TFKDLVNVLRKFPNLKPRTDVYTFNDGSSKLLLNLYGTIPVtYKGntYNIPILIWLPDTYPFSPPICYVKPT---ASMVI 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2130399071 104 ATNESVEPDGRVHTRLLRQWNPQSANLFNVIQDLADMCNAIA 145
Cdd:pfam05743  78 KVNHHVDAQGRVYLPYLHNWNHPSSNLVDLVQELAQVFQEDP 119
UEV_TSG101-like cd11685
ubiquitin E2 variant (UEV) domain of TSG101 and related proteins; This subfamily includes the ...
 25-147 4.15e-28

ubiquitin E2 variant (UEV) domain of TSG101 and related proteins; This subfamily includes the UEV domain of eukaryotic tumor susceptibility gene 101 protein (TSG101, also known as ESCRT-I complex subunit TSG101, vacuolar protein-sorting protein 23, or Vps23) which functions in endocytic trafficking. TSG101 is a component of the ESCRT (endosomal sorting complex required for transport)-I complex, one of four complexes (ESCRT 0, -I, -II, -III) in the vacuolar protein sorting pathway. TSG101 also facilitates HIV-1 virus budding from infected cells, perhaps by linking the p6 domain of the viral structural Gag protein to the vacuolar protein sorting machinery. The UEV domain of TSG101 binds to an essential tetrapeptide motif within the p6 domain of the structural Gag protein and also to ubiquitin. UEVs are homologous to E2 ubiquitin ligases but lack the conserved cysteine residue required for catalytic activity.


Pssm-ID: 467408  Cd Length: 126  Bit Score: 108.16  E-value: 4.15e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130399071  25 KLVFHDAVQTLTEFKNLRPRTRVFTDEDGSPRLLLCLYGGIHI---EQGLDVPVLIWIPESYPIAKPLLFIDLEllGKDL 101
Cdd:cd11685     1 DRVREDLLNLLQKYPSLKPKTDTFTFNDGSSKLLLCLTGTIPItyrGSTYNIPITIWLPETYPYSPPIVYVVPT--PSMM 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2130399071 102 QLATNESVEPDGRVHTRLLRQWNPQSANLFNVIQDLADMCNAIAPI 147
Cdd:cd11685    79 IIKPHPHVDPNGRVYLPYLSEWNPPSSNLVDLVQELSAVFSEEPPV 124
Vps23_core pfam09454
Vps23 core domain; ESCRT complexes form the main machinery driving protein sorting from ...
 398-457 5.81e-20

Vps23 core domain; ESCRT complexes form the main machinery driving protein sorting from endosomes to lysosomes. The core domain of the Vps23 subunit of the heterotrimeric ESCRT-I complex is a helical hairpin sandwiched in a fan-like formation between two other helical hairpins from Vps28 (pfam03997) and Vps37. Vps23 gives ESCRT-I complex its stability.


Pssm-ID: 462803 [Multi-domain]  Cd Length: 60  Bit Score: 83.28  E-value: 5.81e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130399071 398 TVYTTEVPALDQLYTLVARDRALTDTIQVLARLLNCGALEFDAFIKKVRELARDQFMARL 457
Cdd:pfam09454   1 EVVVATTPLSNQLLELVAEDKAIEDTIYLLDKALDRGVIDLDTFLKQVRELAREQFLKRA 60
UBCc smart00212
Ubiquitin-conjugating enzyme E2, catalytic domain homologues; Proteins destined for ...
 12-149 2.95e-03

Ubiquitin-conjugating enzyme E2, catalytic domain homologues; Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. This pathway functions in regulating many fundamental processes required for cell viability.TSG101 is one of several UBC homologues that lacks this active site cysteine.


Pssm-ID: 214562 [Multi-domain]  Cd Length: 145  Bit Score: 38.04  E-value: 2.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130399071   12 WLFKVIQPIYKQPKLVFHDAVqtlTEFKNLRPRTRVFTDEDGSPrlllclY-GGIHieqgldvPVLIWIPESYPIAKPLL 90
Cdd:smart00212   1 RLLKELKELRKDPPPGFTAYP---VDDENLLEWTGTIVGPPGTP------YeGGVF-------KLTIEFPEDYPFKPPKV 64

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2130399071   91 FIDLELLgkdlqlatNESVEPDGRVHTRLLRQ--WNPQSaNLFNVIQDLADMCNAIAPIQP 149
Cdd:smart00212  65 KFITKIY--------HPNVDSSGEICLDILKQekWSPAL-TLETVLLSLQSLLSEPNPDSP 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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