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Conserved domains on  [gi|2130390340|gb|KAH7604542|]
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SAM-dependent methyltransferase PRMT-type domain profile [[Candida] glabrata]

Protein Classification

SAM-dependent methyltransferase( domain architecture ID 1905023)

SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4076 super family cl44002
Predicted RNA methylase [General function prediction only];
33-225 3.17e-45

Predicted RNA methylase [General function prediction only];


The actual alignment was detected with superfamily member COG4076:

Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 154.42  E-value: 3.17e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  33 HEEMLQDTVRTLSYRNAIIQNkdMFKDKVVLDVGCGTGILSMFAAKNGAKHVIGVDMS-SIIEMARNLVELNGFSDKITL 111
Cdd:COG4076    12 HHPMLNDVERNDAFKAAIERV--VKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNpDIAAVARRIIAANGLSDRITV 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340 112 LRGKLEDVELPfPKVDIIISEWMGYFLLYESMLDTVLYARDRYLVEGGLIFPDKCSIHVAGLEDAQYKDekinYWHD--V 189
Cdd:COG4076    90 INADATDLDLP-EKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESPVDAE----GFEDwqF 164

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2130390340 190 YGFDYSPFIPLIMKEPIvdtVERNAVNTTRSQLIEF 225
Cdd:COG4076   165 DGFDFRLFGFLLYAEPL---LHLTRLVRTPLLLLLL 197
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
33-225 3.17e-45

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 154.42  E-value: 3.17e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  33 HEEMLQDTVRTLSYRNAIIQNkdMFKDKVVLDVGCGTGILSMFAAKNGAKHVIGVDMS-SIIEMARNLVELNGFSDKITL 111
Cdd:COG4076    12 HHPMLNDVERNDAFKAAIERV--VKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNpDIAAVARRIIAANGLSDRITV 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340 112 LRGKLEDVELPfPKVDIIISEWMGYFLLYESMLDTVLYARDRYLVEGGLIFPDKCSIHVAGLEDAQYKDekinYWHD--V 189
Cdd:COG4076    90 INADATDLDLP-EKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESPVDAE----GFEDwqF 164

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2130390340 190 YGFDYSPFIPLIMKEPIvdtVERNAVNTTRSQLIEF 225
Cdd:COG4076   165 DGFDFRLFGFLLYAEPL---LHLTRLVRTPLLLLLL 197
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 62-162 1.07e-14

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 69.38  E-value: 1.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  62 VLDVGCGTGILSMFAAKNGAKHVIGVDMSSI-IEMARNlVELNGFSDKITLLRGKLED-VELPFPKVDIIISeWMGYFLL 139
Cdd:cd02440     2 VLDLGCGTGALALALASGPGARVTGVDISPVaLELARK-AAAALLADNVEVLKGDAEElPPEADESFDVIIS-DPPLHHL 79

                          90       100
                  ....*....|....*....|...
gi 2130390340 140 YESMLDTVLYARdRYLVEGGLIF 162
Cdd:cd02440    80 VEDLARFLEEAR-RLLKPGGVLV 101
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 62-131 2.55e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 67.97  E-value: 2.55e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2130390340  62 VLDVGCGTGILSMFAAKNGAKHVIGVDMSSI-IEMARNLVELNGFsdKITLLRGKLEDveLPFP--KVDIIIS 131
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEmLERARERAAEAGL--NVEFVQGDAED--LPFPdgSFDLVVS 69
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
56-130 2.58e-14

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 71.72  E-value: 2.58e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2130390340  56 MFKDKVVLDVGCGTGILSMFAAKNGAKHVIGVDMSSI-IEMARNLVELNGFSDKITLLRGkledvelpFPKVDIII 130
Cdd:PRK00517  117 VLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVDIDPQaVEAARENAELNGVELNVYLPQG--------DLKADVIV 184
prmA TIGR00406
ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an ...
 51-130 2.57e-12

ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an S-adenosyl-L-methionine-dependent methyltransferase required for the modification of ribosomal protein L11. This protein is found in bacteria and (with a probable transit peptide) in Arabidopsis. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273061  Cd Length: 288  Bit Score: 66.40  E-value: 2.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  51 IQNKDMF--KDKVVLDVGCGTGILSMFAAKNGAKHVIGVDMSSI-IEMARNLVELNGFSDKITL-LRGKLEDVELPFpkv 126
Cdd:TIGR00406 150 LEWLEDLdlKDKNVIDVGCGSGILSIAALKLGAAKVVGIDIDPLaVESARKNAELNQVSDRLQVkLIYLEQPIEGKA--- 226


                  ....
gi 2130390340 127 DIII 130
Cdd:TIGR00406 227 DVIV 230
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
33-225 3.17e-45

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 154.42  E-value: 3.17e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  33 HEEMLQDTVRTLSYRNAIIQNkdMFKDKVVLDVGCGTGILSMFAAKNGAKHVIGVDMS-SIIEMARNLVELNGFSDKITL 111
Cdd:COG4076    12 HHPMLNDVERNDAFKAAIERV--VKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNpDIAAVARRIIAANGLSDRITV 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340 112 LRGKLEDVELPfPKVDIIISEWMGYFLLYESMLDTVLYARDRYLVEGGLIFPDKCSIHVAGLEDAQYKDekinYWHD--V 189
Cdd:COG4076    90 INADATDLDLP-EKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVESPVDAE----GFEDwqF 164

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2130390340 190 YGFDYSPFIPLIMKEPIvdtVERNAVNTTRSQLIEF 225
Cdd:COG4076   165 DGFDFRLFGFLLYAEPL---LHLTRLVRTPLLLLLL 197
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
56-130 1.07e-16

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 79.06  E-value: 1.07e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2130390340  56 MFKDKVVLDVGCGTGILSMFAAKNGAKHVIGVDmssI----IEMARNLVELNGFSDKITLLRGKLEDVElpfpKVDIII 130
Cdd:COG2264   146 LKPGKTVLDVGCGSGILAIAAAKLGAKRVLAVD---IdpvaVEAARENAELNGVEDRIEVVLGDLLEDG----PYDLVV 217
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 62-162 1.07e-14

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 69.38  E-value: 1.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  62 VLDVGCGTGILSMFAAKNGAKHVIGVDMSSI-IEMARNlVELNGFSDKITLLRGKLED-VELPFPKVDIIISeWMGYFLL 139
Cdd:cd02440     2 VLDLGCGTGALALALASGPGARVTGVDISPVaLELARK-AAAALLADNVEVLKGDAEElPPEADESFDVIIS-DPPLHHL 79

                          90       100
                  ....*....|....*....|...
gi 2130390340 140 YESMLDTVLYARdRYLVEGGLIF 162
Cdd:cd02440    80 VEDLARFLEEAR-RLLKPGGVLV 101
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 62-131 2.55e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 67.97  E-value: 2.55e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2130390340  62 VLDVGCGTGILSMFAAKNGAKHVIGVDMSSI-IEMARNLVELNGFsdKITLLRGKLEDveLPFP--KVDIIIS 131
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEmLERARERAAEAGL--NVEFVQGDAED--LPFPdgSFDLVVS 69
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
56-130 2.58e-14

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 71.72  E-value: 2.58e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2130390340  56 MFKDKVVLDVGCGTGILSMFAAKNGAKHVIGVDMSSI-IEMARNLVELNGFSDKITLLRGkledvelpFPKVDIII 130
Cdd:PRK00517  117 VLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVDIDPQaVEAARENAELNGVELNVYLPQG--------DLKADVIV 184
prmA TIGR00406
ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an ...
 51-130 2.57e-12

ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an S-adenosyl-L-methionine-dependent methyltransferase required for the modification of ribosomal protein L11. This protein is found in bacteria and (with a probable transit peptide) in Arabidopsis. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273061  Cd Length: 288  Bit Score: 66.40  E-value: 2.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  51 IQNKDMF--KDKVVLDVGCGTGILSMFAAKNGAKHVIGVDMSSI-IEMARNLVELNGFSDKITL-LRGKLEDVELPFpkv 126
Cdd:TIGR00406 150 LEWLEDLdlKDKNVIDVGCGSGILSIAALKLGAAKVVGIDIDPLaVESARKNAELNQVSDRLQVkLIYLEQPIEGKA--- 226


                  ....
gi 2130390340 127 DIII 130
Cdd:TIGR00406 227 DVIV 230
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 58-162 3.50e-12

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 62.73  E-value: 3.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  58 KDKVVLDVGCGTGILSMFAAKNGAkHVIGVDMSS-IIEMARNLVElngfSDKITLLRGKLEDVELPFPKVDIIISewMGY 136
Cdd:COG2227    24 AGGRVLDVGCGTGRLALALARRGA-DVTGVDISPeALEIARERAA----ELNVDFVQGDLEDLPLEDGSFDLVIC--SEV 96

                          90       100
                  ....*....|....*....|....*.
gi 2130390340 137 FLLYESMLDTVLYARdRYLVEGGLIF 162
Cdd:COG2227    97 LEHLPDPAALLRELA-RLLKPGGLLL 121
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 50-131 1.32e-11

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 63.63  E-value: 1.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  50 IIQNKDMFK---DKV-------------VLDVGCGTGILS-MFAAKNGAKHVIGVD-MSSIIEMARNLVELNGFSDKITL 111
Cdd:COG4123    13 IIQPRCGYRfgtDAVllaafapvkkggrVLDLGTGTGVIAlMLAQRSPGARITGVEiQPEAAELARRNVALNGLEDRITV 92

                          90       100
                  ....*....|....*....|..
gi 2130390340 112 LRGKLEDVELPFP--KVDIIIS 131
Cdd:COG4123    93 IHGDLKEFAAELPpgSFDLVVS 114
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 62-162 1.70e-11

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 61.87  E-value: 1.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  62 VLDVGCGTGILSMFAAKNGAKHVIGVDMS-SIIEMARNLVELNGFSDKITLLRGKLEDVELPfPKVDIIIS----EWMGY 136
Cdd:COG2230    55 VLDIGCGWGGLALYLARRYGVRVTGVTLSpEQLEYARERAAEAGLADRVEVRLADYRDLPAD-GQFDAIVSigmfEHVGP 133

                          90       100
                  ....*....|....*....|....*.
gi 2130390340 137 fLLYESMLDTVlyarDRYLVEGGLIF 162
Cdd:COG2230   134 -ENYPAYFAKV----ARLLKPGGRLL 154
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 58-130 8.60e-11

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 61.90  E-value: 8.60e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2130390340  58 KDKVVLDVGCGTGILSMFAAKNGAKHVIGVDMSSI-IEMARNLVELNGFSDKITLlrgKLEDvELPFPKVDIII 130
Cdd:pfam06325 161 PGESVLDVGCGSGILAIAALKLGAKKVVGVDIDPVaVRAAKENAELNGVEARLEV---YLPG-DLPKEKADVVV 230
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 58-131 1.25e-10

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 58.85  E-value: 1.25e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2130390340  58 KDKVVLDVGCGTGILSMFAAKNGAkHVIGVDMS-SIIEMARNLVELNGFsdKITLLRGKLEDveLPFP--KVDIIIS 131
Cdd:COG2226    22 PGARVLDLGCGTGRLALALAERGA-RVTGVDISpEMLELARERAAEAGL--NVEFVVGDAED--LPFPdgSFDLVIS 93
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 62-131 2.55e-10

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 59.16  E-value: 2.55e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2130390340  62 VLDVGCGTGILSMFAAKNGAKHVIGVDMS-SIIEMARNLVELNGFSdKITLLRGKLED-VELPFPKVDIIIS 131
Cdd:COG0500    30 VLDLGCGTGRNLLALAARFGGRVIGIDLSpEAIALARARAAKAGLG-NVEFLVADLAElDPLPAESFDLVVA 100
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 55-114 4.51e-10

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 60.20  E-value: 4.51e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2130390340  55 DMFKDKVVLDVGCGTGILSMFAAKNGAKHVIGVDMS-SIIEMARNLVELNGFSDKITLLRG 114
Cdd:COG1092   213 ELAKGKRVLNLFSYTGGFSVHAAAGGAKSVTSVDLSaTALEWAKENAALNGLDDRHEFVQA 273
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 57-161 1.47e-09

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 57.20  E-value: 1.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  57 FKDKVVLDVGCGTGILSMFAAKNGAKHVIGVDmssIIEMARNLV----ELNGFsdKITLLRGKLEDVElPFPKVDIII-S 131
Cdd:COG3897    69 VAGKRVLELGCGLGLVGIAAAKAGAADVTATD---YDPEALAALrlnaALNGV--AITTRLGDWRDPP-AAGGFDLILgG 142

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2130390340 132 EwmgyfLLYE-SMLDTVLYARDRYLVEGGLI 161
Cdd:COG3897   143 D-----VLYErDLAEPLLPFLDRLAAPGGEV 168
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
10-162 6.25e-09

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 55.00  E-value: 6.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  10 ATDKQNLNQYEQhYFTSYDH-------YGIHEEMLQDTVRTLSYRnaiiqnkdmfKDKVVLDVGCGTGILSMFAAKNGaK 82
Cdd:COG4976     2 ALDAYVEALFDQ-YADSYDAalvedlgYEAPALLAEELLARLPPG----------PFGRVLDLGCGTGLLGEALRPRG-Y 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  83 HVIGVDMSS-IIEMARNLvelngfSDKITLLRGKLEDVELPFPKVDIIISewmGYFLLYESMLDTVLYARDRYLVEGG-L 160
Cdd:COG4976    70 RLTGVDLSEeMLAKAREK------GVYDRLLVADLADLAEPDGRFDLIVA---ADVLTYLGDLAAVFAGVARALKPGGlF 140


                  ..
gi 2130390340 161 IF 162
Cdd:COG4976   141 IF 142
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
57-131 1.20e-08

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 54.14  E-value: 1.20e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2130390340  57 FKDKVVLDVGCGTGILSMFAAKNGAKHVIGVDMS-SIIEMARNLVElnGFSDKITLLRGKLEDVELPFPkVDIIIS 131
Cdd:COG2263    44 IEGKTVLDLGCGTGMLAIGAALLGAKKVVGVDIDpEALEIARENAE--RLGVRVDFIRADVTRIPLGGS-VDTVVM 116
PRK14968 PRK14968
putative methyltransferase; Provisional
 58-162 1.76e-08

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 53.75  E-value: 1.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  58 KDKVVLDVGCGTGILSMFAAKNGAKhVIGVDMS-SIIEMARNLVELNGF---------SDKITLLRGKLEDV------EL 121
Cdd:PRK14968   23 KGDRVLEVGTGSGIVAIVAAKNGKK-VVGVDINpYAVECAKCNAKLNNIrnngvevirSDLFEPFRGDKFDVilfnppYL 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2130390340 122 PFPKVDiIISEWMGYFL--------LYESMLDTVlyarDRYLVEGGLIF 162
Cdd:PRK14968  102 PTEEEE-EWDDWLNYALsggkdgreVIDRFLDEV----GRYLKPGGRIL 145
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 56-131 2.19e-08

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 52.42  E-value: 2.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  56 MFKDKVVLDVGCGTGILSMFAAK--NGAKHVIGVDMS-SIIEMARNLVELNGFSDkITLLRGKLEDVELPFP--KVDIII 130
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEelGPNAEVVGIDISeEAIEKARENAQKLGFDN-VEFEQGDIEELPELLEddKFDVVI 79


                  .
gi 2130390340 131 S 131
Cdd:pfam13847  80 S 80
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 63-134 2.90e-08

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 50.74  E-value: 2.90e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2130390340  63 LDVGCGTGILSMFAAKNGAkHVIGVDMSsiiEMARNLVELNGFSDKITLLRGKLEDveLPFP--KVDIIISEWM 134
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA-RVTGVDIS---PEMLELAREKAPREGLTFVVGDAED--LPFPdnSFDLVLSSEV 68
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
62-131 1.32e-07

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 49.05  E-value: 1.32e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2130390340  62 VLDVGCGTGILS-MFAAKNGAKHVIGVDMS-SIIEMARNLVelngfsDKITLLRGKLEDVELPfPKVDIIIS 131
Cdd:COG4106     5 VLDLGCGTGRLTaLLAERFPGARVTGVDLSpEMLARARARL------PNVRFVVADLRDLDPP-EPFDLVVS 69
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 33-119 3.07e-07

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 50.61  E-value: 3.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  33 HEEMLqDTVrtLSYrnaiIQNKDMFKDKVVLDVGCGTGILSMFAAKNGAKhVIGVDMSS-IIEMARNLVELNGFSDKITL 111
Cdd:PRK07580   45 HQRMR-DTV--LSW----LPADGDLTGLRILDAGCGVGSLSIPLARRGAK-VVASDISPqMVEEARERAPEAGLAGNITF 116


                  ....*...
gi 2130390340 112 LRGKLEDV 119
Cdd:PRK07580  117 EVGDLESL 124
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 58-130 6.52e-07

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 50.56  E-value: 6.52e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2130390340  58 KDKVVLDVGCGTGILSMFAAKNgAKHVIGVDMS-SIIEMARNLVELNGFsDKITLLRGKLEDV---ELPFPKVDIII 130
Cdd:COG2265   233 GGERVLDLYCGVGTFALPLARR-AKKVIGVEIVpEAVEDARENARLNGL-KNVEFVAGDLEEVlpeLLWGGRPDVVV 307
arsM PRK11873
arsenite methyltransferase;
61-131 2.28e-06

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 48.41  E-value: 2.28e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2130390340  61 VVLDVGCGTGILSMFAAKN-GAK-HVIGVDMS-SIIEMARNLVELNGFSDkITLLRGKLEDVELPFPKVDIIIS 131
Cdd:PRK11873   80 TVLDLGSGGGFDCFLAARRvGPTgKVIGVDMTpEMLAKARANARKAGYTN-VEFRLGEIEALPVADNSVDVIIS 152
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 63-161 5.39e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 44.28  E-value: 5.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  63 LDVGCGTG-ILSMFAAKNGAKHVIGVDMSSI-IEMARNLVELNGFsDKITLLRGKLEDV-ELPFPKVDIIIsewMGYFLL 139
Cdd:pfam08242   1 LEIGCGTGtLLRALLEALPGLEYTGLDISPAaLEAARERLAALGL-LNAVRVELFQLDLgELDPGSFDVVV---ASNVLH 76

                          90       100
                  ....*....|....*....|..
gi 2130390340 140 YESMLDTVLYARDRYLVEGGLI 161
Cdd:pfam08242  77 HLADPRAVLRNIRRLLKPGGVL 98
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 62-124 1.03e-05

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 46.30  E-value: 1.03e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2130390340  62 VLDVGCGTGILSMFAAKNGAK--HVIGVDMSSiiEM---ARNLVELNGFSDKITLLRGKLEdvELPFP 124
Cdd:PRK00216   55 VLDLACGTGDLAIALAKAVGKtgEVVGLDFSE--GMlavGREKLRDLGLSGNVEFVQGDAE--ALPFP 118
FtsJ pfam01728
FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal ...
 58-131 1.50e-05

FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesized that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping.


Pssm-ID: 426399  Cd Length: 179  Bit Score: 44.89  E-value: 1.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  58 KDKVVLDVGCGTGILSMFAAKNGAKHVIGVDmssIIEMarNLVELNGFsDKITLLRG---KLEDVELPFP----KVDIII 130
Cdd:pfam01728  21 PGKTVLDLGAAPGGWSQVALQRGAGKVVGVD---LGPM--QLWKPRND-PGVTFIQGdirDPETLDLLEEllgrKVDLVL 94


                  .
gi 2130390340 131 S 131
Cdd:pfam01728  95 S 95
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 61-131 1.66e-05

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 45.91  E-value: 1.66e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2130390340  61 VVLDVGCGTGI--LSMFAAKNGAkHVIGVDMSSI-IEMAR-NlVELNGFSDKITLLRGKLEDVELPFPKVDIIIS 131
Cdd:COG2890   115 RVLDLGTGSGAiaLALAKERPDA-RVTAVDISPDaLAVARrN-AERLGLEDRVRFLQGDLFEPLPGDGRFDLIVS 187
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 49-131 2.52e-05

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 45.15  E-value: 2.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  49 AIIQNKDMFKDKVVLDVGCGTGILS-MFAAKNGAKHVIGVDMSSI-IEMAR-NLVELNGfsDKITLLRGKLEDvELPFPK 125
Cdd:PRK09328   99 WALEALLLKEPLRVLDLGTGSGAIAlALAKERPDAEVTAVDISPEaLAVARrNAKHGLG--ARVEFLQGDWFE-PLPGGR 175


                  ....*.
gi 2130390340 126 VDIIIS 131
Cdd:PRK09328  176 FDLIVS 181
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
45-131 5.62e-05

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 44.12  E-value: 5.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  45 SYRNAIIQNKDMFKDKVVLDVGCGTGILSMFAAKNGAK-HVIGVDmSSIIEMARNLVELNGfsdKITLLRGkleD-VELP 122
Cdd:PRK14896   16 RVVDRIVEYAEDTDGDPVLEIGPGKGALTDELAKRAKKvYAIELD-PRLAEFLRDDEIAAG---NVEIIEG---DaLKVD 88


                  ....*....
gi 2130390340 123 FPKVDIIIS 131
Cdd:PRK14896   89 LPEFNKVVS 97
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 50-161 6.38e-05

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 43.15  E-value: 6.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  50 IIQNKdmFKDKVVLDVGCGTGILSMFAAKNGAKHVIGVDMS----SIIEmaRNLVELnGFSDKITLLRGkleDVE----- 120
Cdd:COG0742    35 ILGPD--IEGARVLDLFAGSGALGLEALSRGAASVVFVEKDrkaaAVIR--KNLEKL-GLEDRARVIRG---DALrflkr 106

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2130390340 121 LPFPKVDIIisewmgyFL-------LYESMLDTVlyARDRYLVEGGLI 161
Cdd:COG0742   107 LAGEPFDLV-------FLdppyakgLLEKALELL--AENGLLAPGGLI 145
CMAS pfam02353
Mycolic acid cyclopropane synthetase; This family consist of ...
 62-126 1.03e-04

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


Pssm-ID: 396777 [Multi-domain]  Cd Length: 272  Bit Score: 43.47  E-value: 1.03e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2130390340  62 VLDVGCGTGILSMFAAKNGAKHVIGVDMSS-IIEMARNLVELNGFSDKITLLRGKLEDVELPFPKV 126
Cdd:pfam02353  65 LLDIGCGWGGLMRRAAERYDVNVVGLTLSKnQYKLARKRVAAEGLARKVEVLLQDYRDFDEPFDRI 130
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 48-131 1.16e-04

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 43.11  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  48 NAIIQNKDMFKdkvVLDVGCGTGILSM-FAAKNGAKHVIGVD-MSSIIEMARNLVELNGFSDKITLLRGKLEDvELPFPK 125
Cdd:TIGR00536 107 ASLISQPPILH---ILDLGTGSGCIALaLAYEFPNAEVIAVDiSPDALAVAEENAEKNQLEHRVEFIQSNLFE-PLAGQK 182


                  ....*.
gi 2130390340 126 VDIIIS 131
Cdd:TIGR00536 183 IDIIVS 188
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 49-131 1.20e-04

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 43.04  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  49 AIIQNKDMFKDKVVLDVGCGTGILS-MFAAKNGAKHVIGVDMSSiiEMARNLVELNgfSDKITLLRGKLEDVELPFPKVD 127
Cdd:TIGR02072  25 ALLKEKGIFIPASVLDIGCGTGYLTrALLKRFPQAEFIALDISA--GMLAQAKTKL--SENVQFICGDAEKLPLEDSSFD 100


                  ....
gi 2130390340 128 IIIS 131
Cdd:TIGR02072 101 LIVS 104
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 62-131 2.28e-04

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 41.71  E-value: 2.28e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2130390340  62 VLDVGCGTGILSMFAAK-NGAKHVIGVDMSSI-IEMARNLVELNGFSDkITLLRGkleDVELPFP--KVDIIIS 131
Cdd:COG2813    53 VLDLGCGYGVIGLALAKrNPEARVTLVDVNARaVELARANAAANGLEN-VEVLWS---DGLSGVPdgSFDLILS 122
PRK08317 PRK08317
hypothetical protein; Provisional
 62-132 2.30e-04

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 42.23  E-value: 2.30e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2130390340  62 VLDVGCGTGILSM-FAAKNGAK-HVIGVDMS-SIIEMARNLVELNGfsDKITLLRGKLEDveLPFPK--VDIIISE 132
Cdd:PRK08317   23 VLDVGCGPGNDAReLARRVGPEgRVVGIDRSeAMLALAKERAAGLG--PNVEFVRGDADG--LPFPDgsFDAVRSD 94
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 51-131 3.31e-04

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 40.65  E-value: 3.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  51 IQNKDMFKDKVVLDVGCGTGILSMFAAKNGAKhvIGVDMSSIIEMArnlVElngfSDKITLLRGKLEDVE---------L 121
Cdd:pfam05175  24 LEHLPKDLSGKVLDLGCGAGVLGAALAKESPD--AELTMVDINARA---LE----SARENLAANGLENGEvvasdvysgV 94

                          90
                  ....*....|
gi 2130390340 122 PFPKVDIIIS 131
Cdd:pfam05175  95 EDGKFDLIIS 104
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 56-161 3.88e-04

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 40.55  E-value: 3.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  56 MFKDKVVLDVGCGTGI--LSMFAAKNGAKHVIGVDMS-SIIEMARNLVELNGFSDKITLLRGKLEDV--ELPFPKVDIIi 130
Cdd:COG4122    14 LLGAKRILEIGTGTGYstLWLARALPDDGRLTTIEIDpERAAIARENFARAGLADRIRLILGDALEVlpRLADGPFDLV- 92

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 2130390340 131 sewmgyFL-----LYESMLDTVLyardRYLVEGGLI 161
Cdd:COG4122    93 ------FIdadksNYPDYLELAL----PLLRPGGLI 118
Rsm22 COG5459
Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal ...
 57-138 7.01e-04

Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal structure and biogenesis]; Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 444210 [Multi-domain]  Cd Length: 306  Bit Score: 41.09  E-value: 7.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  57 FKDKVVLDVGCGTG--ILSMFAAKNGAKHVIGVDMS-SIIEMARNLVElNGFSDKITLLRGKLEDV--ELPFPKVDIIIs 131
Cdd:COG5459    79 FAPLTVLDVGAGPGtaAWAAADAWPSLLDATLLERSaAALALGRRLAR-AAANPALETAEWRLADLaaALPAPPADLVV- 156


                  ....*..
gi 2130390340 132 ewMGYFL 138
Cdd:COG5459   157 --ASYVL 161
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 56-201 7.06e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 39.72  E-value: 7.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  56 MFKDKVVLDVGCGTGILSMFAAKNGAkHVIGVDMSSI-IEMARNLVELNGFSDkitllrgklEDVELPFPKVDIIISewm 134
Cdd:pfam13489  20 LPSPGRVLDFGCGTGIFLRLLRAQGF-SVTGVDPSPIaIERALLNVRFDQFDE---------QEAAVPAGKFDVIVA--- 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2130390340 135 gyFLLYESMLDTVLYARD--RYLVEGGLIFpdkcsIHVAGLEDAQykDEKINYWHdvYGFDYSPFIPLI 201
Cdd:pfam13489  87 --REVLEHVPDPPALLRQiaALLKPGGLLL-----LSTPLASDEA--DRLLLEWP--YLRPRNGHISLF 144
PRK15068 PRK15068
tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;
58-88 1.21e-03

tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;


Pssm-ID: 237898  Cd Length: 322  Bit Score: 40.23  E-value: 1.21e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2130390340  58 KDKVVLDVGCGTG--ILSMFAAknGAKHVIGVD 88
Cdd:PRK15068  122 KGRTVLDVGCGNGyhMWRMLGA--GAKLVVGID 152
PRK14967 PRK14967
putative methyltransferase; Provisional
 62-131 1.35e-03

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 39.65  E-value: 1.35e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2130390340  62 VLDVGCGTGILSMFAAKNGAKHVIGVDMS-SIIEMARNLVELNGFsdKITLLRGKLEDVeLPFPKVDIIIS 131
Cdd:PRK14967   40 VLDLCTGSGALAVAAAAAGAGSVTAVDISrRAVRSARLNALLAGV--DVDVRRGDWARA-VEFRPFDVVVS 107
rlmL PRK11783
bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2)) ...
 55-108 1.47e-03

bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL;


Pssm-ID: 236981 [Multi-domain]  Cd Length: 702  Bit Score: 40.56  E-value: 1.47e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2130390340  55 DMFKDKVVLDVGCGTGILSMFAAKNGAKHVIGVDMSSI-IEMARNLVELNGFSDK 108
Cdd:PRK11783  535 QMAKGKDFLNLFAYTGTASVHAALGGAKSTTTVDMSNTyLEWAERNFALNGLSGR 589
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 58-132 1.54e-03

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 38.78  E-value: 1.54e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2130390340  58 KDKVVLDVGCGTGILSMFAAKNGAKhVIGVDMSS-IIEMARNLVELNGFSDkITLLRGKLEDVELPFPKVDIIISE 132
Cdd:COG1041    26 EGDTVLDPFCGTGTILIEAGLLGRR-VIGSDIDPkMVEGARENLEHYGYED-ADVIRGDARDLPLADESVDAIVTD 99
cbiT PRK00377
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
 36-181 3.37e-03

cobalt-precorrin-6Y C(15)-methyltransferase; Provisional


Pssm-ID: 234740  Cd Length: 198  Bit Score: 38.24  E-value: 3.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  36 MLQDTVRTLSYRNAIIqnkdmFKDKVVLDVGCGTGILSMFAA---KNGAKhVIGVDMSS-IIEMARNLVELNGFSDKITL 111
Cdd:PRK00377   23 MTKEEIRALALSKLRL-----RKGDMILDIGCGTGSVTVEASllvGETGK-VYAVDKDEkAINLTRRNAEKFGVLNNIVL 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2130390340 112 LRGKLEDVelpfpkVDIIISEWMGYFLLYESM-LDTVLYARDRYLVEGGLIFPDKCSIH-----VAGLEDAQYKDE 181
Cdd:PRK00377   97 IKGEAPEI------LFTINEKFDRIFIGGGSEkLKEIISASWEIIKKGGRIVIDAILLEtvnnaLSALENIGFNLE 166
PTZ00338 PTZ00338
dimethyladenosine transferase-like protein; Provisional
 49-123 6.18e-03

dimethyladenosine transferase-like protein; Provisional


Pssm-ID: 240367 [Multi-domain]  Cd Length: 294  Bit Score: 38.06  E-value: 6.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  49 AIIQNKDMFKDKVVLDVGCGTGILSMFAAKNgAKHVIGVDMSsiiemARNLVELN------GFSDKITLLRGKLEDVELP 122
Cdd:PTZ00338   27 KIVEKAAIKPTDTVLEIGPGTGNLTEKLLQL-AKKVIAIEID-----PRMVAELKkrfqnsPLASKLEVIEGDALKTEFP 100


                  .
gi 2130390340 123 F 123
Cdd:PTZ00338  101 Y 101
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 59-161 7.84e-03

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 37.92  E-value: 7.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130390340  59 DKVVLDVGCGTGILSMFAAKNGAKHVIGVDM--SSIIEMARNlVELNGFSDKITLLRGkleDV-ELPF---PKVDIIIse 132
Cdd:COG2520   181 GERVLDMFAGVGPFSIPIAKRSGAKVVAIDInpDAVEYLKEN-IRLNKVEDRVTPILG---DArEVAPeleGKADRII-- 254

                          90       100
                  ....*....|....*....|....*....
gi 2130390340 133 wMGYFLLYESMLDTVLYArdryLVEGGLI 161
Cdd:COG2520   255 -MNLPHSADEFLDAALRA----LKPGGVI 278
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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