NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2130377892|gb|KAH7593661|]
View 

Fungal tRNA ligase phosphodiesterase domain [[Candida] glabrata]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
RNA_lig_T4_1 pfam09511
RNA ligase; Members of this family include T4 phage proteins with ATP-dependent RNA ligase ...
61-288 7.15e-111

RNA ligase; Members of this family include T4 phage proteins with ATP-dependent RNA ligase activity. Host defence to phage may include cleavage and inactivation of specific tRNA molecules; members of this family act to reverse this RNA damage. The enzyme is adenylated, transiently, on a Lys residue in a motif KXDGSL. This family also includes fungal tRNA ligases that have adenylyltransferase activity. tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns.i


:

Pssm-ID: 462821  Cd Length: 221  Bit Score: 337.67  E-value: 7.15e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130377892  61 ARGLFITDDSKnPQIVARGYDKFFNIDETPFTRWDTLESDTKGTYNVTLKANGCIIFVSGMADGTLVVCSKHSTGPrdDV 140
Cdd:pfam09511   2 ARGLFTDEDTE-HRIVVRGYDKFFNINEVPETKWEEIELNTKGPYELTEKENGCIIFISGLEDGTLVVTSKHSTGP--DS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130377892 141 DRNHADAGEQFLLSQLKSIGIEPQQLALELYQNNVTAVAEYCDDTFEEHILEYTNDDVGLYLHGINYNETTFRTWDMDSV 220
Cdd:pfam09511  79 NRSHAEAGERWLEKQLAKEGKTYEELAKELRERNVTAVFELCDDSFEEHIVAYYPEKAGLYLHGINYNTPEFVTYPMEEV 158
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2130377892 221 SEFARKYNFKQIKYENFNDFTLLKKFLEECSNSGTYHGQEVEGFVIRCKtrengNDFFFKYKFEEPYL 288
Cdd:pfam09511 159 QKFAKEWGFKKTEFVTLDDIEEVKKFLEEVAETGSYNGREIEGFVIRCK-----SGDMFKYKFKEPYY 221
tRNA_lig_kinase pfam08303
tRNA ligase kinase domain; This domain is found in fungal tRNA ligases and has kinase activity. ...
389-557 2.39e-99

tRNA ligase kinase domain; This domain is found in fungal tRNA ligases and has kinase activity. tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns. This family contains a P-loop motif.


:

Pssm-ID: 400549  Cd Length: 168  Bit Score: 305.48  E-value: 2.39e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130377892 389 LIIPVAVIGCGKTTTAMTINNIYPEsWGHVQNDNITGKDNSLLMKRSLELLAKPGIKCVVVDRNNHQARERKELFDWIDE 468
Cdd:pfam08303   1 LLVPIATIGCGKTTVSLTLNNLFPE-WGHVQNDNITGKDKSKLMKAALELLAKDGSSVVIADRNNHQSRERKQLFTWIDQ 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130377892 469 YKEDYLPYDTNIKVICLSFTKRDDLENVREITTNRVFARGDDHQSIKLSKYGEKKVMGIMSGFIKRFQPVNEDRMPDIMF 548
Cdd:pfam08303  80 LKDNYLPYDTNLKVIALSFVDEDDLEEVREITRDRVLKRGDNHQSIKVESMGEKKVMGIMNGFIKRFQPVNPAKSPDNMF 159

                  ....*....
gi 2130377892 549 DHVIDLTVT 557
Cdd:pfam08303 160 DLVIELDVL 168
tRNA_lig_CPD pfam08302
Fungal tRNA ligase phosphodiesterase domain; This domain is found in fungal tRNA ligases and ...
561-830 4.13e-75

Fungal tRNA ligase phosphodiesterase domain; This domain is found in fungal tRNA ligases and has cyclic phosphodiesterase activity. tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns.


:

Pssm-ID: 400548  Cd Length: 253  Bit Score: 244.83  E-value: 4.13e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130377892 561 SSLINAKRILNNLHDKYPVLVPTVPTDEEIRAAFEKSL-EYKPTTVKIINEKGSRRNKNKDKKHTSAPTMKKLKPVYFFA 639
Cdd:pfam08302   1 SSRENLETVVNELHKKYPKLVPEMPSAEELDEAIDAALnDYKPDIKHDIGGRGKKKKKNQNNQQQQSPRPKKKKPEYFSV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130377892 640 ELrDPTKLLRCIKAFIEENRSSIDNDSYIHidRLFQDKKYQEKLHVTLIHlMQGKKgteTQQQLWDDYLRSFDEYLTVNP 719
Cdd:pfam08302  81 SL-PTAEVNSILDSLFKDPSASPETSRFYK--QLKQSRRVQPEFHVTLIH-RASKK---EHPELWQRYTKLYKEALAKAP 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130377892 720 ETFDKNCDriKTKYSIKVTVQSLYWDSKIATLTVKpeLVEVErdgslnTLACCNDIPHITLGILEEGIKPVYSNELLKMM 799
Cdd:pfam08302 154 SKSPTSAE--PTLGSCDVRLERLVWDDRIMAIVVR--LVPPE------DWECANKVPHITVGTLSPGVKPKESNDLLKRW 223
                         250       260       270
                  ....*....|....*....|....*....|.
gi 2130377892 800 nQNDKESRPANSFCLELAGLEVQIADVYIHL 830
Cdd:pfam08302 224 -LEEGSGGDTGIGELEIPGKPVLEGTVRGVL 253
 
Name Accession Description Interval E-value
RNA_lig_T4_1 pfam09511
RNA ligase; Members of this family include T4 phage proteins with ATP-dependent RNA ligase ...
61-288 7.15e-111

RNA ligase; Members of this family include T4 phage proteins with ATP-dependent RNA ligase activity. Host defence to phage may include cleavage and inactivation of specific tRNA molecules; members of this family act to reverse this RNA damage. The enzyme is adenylated, transiently, on a Lys residue in a motif KXDGSL. This family also includes fungal tRNA ligases that have adenylyltransferase activity. tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns.i


Pssm-ID: 462821  Cd Length: 221  Bit Score: 337.67  E-value: 7.15e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130377892  61 ARGLFITDDSKnPQIVARGYDKFFNIDETPFTRWDTLESDTKGTYNVTLKANGCIIFVSGMADGTLVVCSKHSTGPrdDV 140
Cdd:pfam09511   2 ARGLFTDEDTE-HRIVVRGYDKFFNINEVPETKWEEIELNTKGPYELTEKENGCIIFISGLEDGTLVVTSKHSTGP--DS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130377892 141 DRNHADAGEQFLLSQLKSIGIEPQQLALELYQNNVTAVAEYCDDTFEEHILEYTNDDVGLYLHGINYNETTFRTWDMDSV 220
Cdd:pfam09511  79 NRSHAEAGERWLEKQLAKEGKTYEELAKELRERNVTAVFELCDDSFEEHIVAYYPEKAGLYLHGINYNTPEFVTYPMEEV 158
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2130377892 221 SEFARKYNFKQIKYENFNDFTLLKKFLEECSNSGTYHGQEVEGFVIRCKtrengNDFFFKYKFEEPYL 288
Cdd:pfam09511 159 QKFAKEWGFKKTEFVTLDDIEEVKKFLEEVAETGSYNGREIEGFVIRCK-----SGDMFKYKFKEPYY 221
tRNA_lig_kinase pfam08303
tRNA ligase kinase domain; This domain is found in fungal tRNA ligases and has kinase activity. ...
389-557 2.39e-99

tRNA ligase kinase domain; This domain is found in fungal tRNA ligases and has kinase activity. tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns. This family contains a P-loop motif.


Pssm-ID: 400549  Cd Length: 168  Bit Score: 305.48  E-value: 2.39e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130377892 389 LIIPVAVIGCGKTTTAMTINNIYPEsWGHVQNDNITGKDNSLLMKRSLELLAKPGIKCVVVDRNNHQARERKELFDWIDE 468
Cdd:pfam08303   1 LLVPIATIGCGKTTVSLTLNNLFPE-WGHVQNDNITGKDKSKLMKAALELLAKDGSSVVIADRNNHQSRERKQLFTWIDQ 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130377892 469 YKEDYLPYDTNIKVICLSFTKRDDLENVREITTNRVFARGDDHQSIKLSKYGEKKVMGIMSGFIKRFQPVNEDRMPDIMF 548
Cdd:pfam08303  80 LKDNYLPYDTNLKVIALSFVDEDDLEEVREITRDRVLKRGDNHQSIKVESMGEKKVMGIMNGFIKRFQPVNPAKSPDNMF 159

                  ....*....
gi 2130377892 549 DHVIDLTVT 557
Cdd:pfam08303 160 DLVIELDVL 168
tRNA_lig_CPD pfam08302
Fungal tRNA ligase phosphodiesterase domain; This domain is found in fungal tRNA ligases and ...
561-830 4.13e-75

Fungal tRNA ligase phosphodiesterase domain; This domain is found in fungal tRNA ligases and has cyclic phosphodiesterase activity. tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns.


Pssm-ID: 400548  Cd Length: 253  Bit Score: 244.83  E-value: 4.13e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130377892 561 SSLINAKRILNNLHDKYPVLVPTVPTDEEIRAAFEKSL-EYKPTTVKIINEKGSRRNKNKDKKHTSAPTMKKLKPVYFFA 639
Cdd:pfam08302   1 SSRENLETVVNELHKKYPKLVPEMPSAEELDEAIDAALnDYKPDIKHDIGGRGKKKKKNQNNQQQQSPRPKKKKPEYFSV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130377892 640 ELrDPTKLLRCIKAFIEENRSSIDNDSYIHidRLFQDKKYQEKLHVTLIHlMQGKKgteTQQQLWDDYLRSFDEYLTVNP 719
Cdd:pfam08302  81 SL-PTAEVNSILDSLFKDPSASPETSRFYK--QLKQSRRVQPEFHVTLIH-RASKK---EHPELWQRYTKLYKEALAKAP 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130377892 720 ETFDKNCDriKTKYSIKVTVQSLYWDSKIATLTVKpeLVEVErdgslnTLACCNDIPHITLGILEEGIKPVYSNELLKMM 799
Cdd:pfam08302 154 SKSPTSAE--PTLGSCDVRLERLVWDDRIMAIVVR--LVPPE------DWECANKVPHITVGTLSPGVKPKESNDLLKRW 223
                         250       260       270
                  ....*....|....*....|....*....|.
gi 2130377892 800 nQNDKESRPANSFCLELAGLEVQIADVYIHL 830
Cdd:pfam08302 224 -LEEGSGGDTGIGELEIPGKPVLEGTVRGVL 253
 
Name Accession Description Interval E-value
RNA_lig_T4_1 pfam09511
RNA ligase; Members of this family include T4 phage proteins with ATP-dependent RNA ligase ...
61-288 7.15e-111

RNA ligase; Members of this family include T4 phage proteins with ATP-dependent RNA ligase activity. Host defence to phage may include cleavage and inactivation of specific tRNA molecules; members of this family act to reverse this RNA damage. The enzyme is adenylated, transiently, on a Lys residue in a motif KXDGSL. This family also includes fungal tRNA ligases that have adenylyltransferase activity. tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns.i


Pssm-ID: 462821  Cd Length: 221  Bit Score: 337.67  E-value: 7.15e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130377892  61 ARGLFITDDSKnPQIVARGYDKFFNIDETPFTRWDTLESDTKGTYNVTLKANGCIIFVSGMADGTLVVCSKHSTGPrdDV 140
Cdd:pfam09511   2 ARGLFTDEDTE-HRIVVRGYDKFFNINEVPETKWEEIELNTKGPYELTEKENGCIIFISGLEDGTLVVTSKHSTGP--DS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130377892 141 DRNHADAGEQFLLSQLKSIGIEPQQLALELYQNNVTAVAEYCDDTFEEHILEYTNDDVGLYLHGINYNETTFRTWDMDSV 220
Cdd:pfam09511  79 NRSHAEAGERWLEKQLAKEGKTYEELAKELRERNVTAVFELCDDSFEEHIVAYYPEKAGLYLHGINYNTPEFVTYPMEEV 158
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2130377892 221 SEFARKYNFKQIKYENFNDFTLLKKFLEECSNSGTYHGQEVEGFVIRCKtrengNDFFFKYKFEEPYL 288
Cdd:pfam09511 159 QKFAKEWGFKKTEFVTLDDIEEVKKFLEEVAETGSYNGREIEGFVIRCK-----SGDMFKYKFKEPYY 221
tRNA_lig_kinase pfam08303
tRNA ligase kinase domain; This domain is found in fungal tRNA ligases and has kinase activity. ...
389-557 2.39e-99

tRNA ligase kinase domain; This domain is found in fungal tRNA ligases and has kinase activity. tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns. This family contains a P-loop motif.


Pssm-ID: 400549  Cd Length: 168  Bit Score: 305.48  E-value: 2.39e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130377892 389 LIIPVAVIGCGKTTTAMTINNIYPEsWGHVQNDNITGKDNSLLMKRSLELLAKPGIKCVVVDRNNHQARERKELFDWIDE 468
Cdd:pfam08303   1 LLVPIATIGCGKTTVSLTLNNLFPE-WGHVQNDNITGKDKSKLMKAALELLAKDGSSVVIADRNNHQSRERKQLFTWIDQ 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130377892 469 YKEDYLPYDTNIKVICLSFTKRDDLENVREITTNRVFARGDDHQSIKLSKYGEKKVMGIMSGFIKRFQPVNEDRMPDIMF 548
Cdd:pfam08303  80 LKDNYLPYDTNLKVIALSFVDEDDLEEVREITRDRVLKRGDNHQSIKVESMGEKKVMGIMNGFIKRFQPVNPAKSPDNMF 159

                  ....*....
gi 2130377892 549 DHVIDLTVT 557
Cdd:pfam08303 160 DLVIELDVL 168
tRNA_lig_CPD pfam08302
Fungal tRNA ligase phosphodiesterase domain; This domain is found in fungal tRNA ligases and ...
561-830 4.13e-75

Fungal tRNA ligase phosphodiesterase domain; This domain is found in fungal tRNA ligases and has cyclic phosphodiesterase activity. tRNA ligases are enzymes required for the splicing of precursor tRNA molecules containing introns.


Pssm-ID: 400548  Cd Length: 253  Bit Score: 244.83  E-value: 4.13e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130377892 561 SSLINAKRILNNLHDKYPVLVPTVPTDEEIRAAFEKSL-EYKPTTVKIINEKGSRRNKNKDKKHTSAPTMKKLKPVYFFA 639
Cdd:pfam08302   1 SSRENLETVVNELHKKYPKLVPEMPSAEELDEAIDAALnDYKPDIKHDIGGRGKKKKKNQNNQQQQSPRPKKKKPEYFSV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130377892 640 ELrDPTKLLRCIKAFIEENRSSIDNDSYIHidRLFQDKKYQEKLHVTLIHlMQGKKgteTQQQLWDDYLRSFDEYLTVNP 719
Cdd:pfam08302  81 SL-PTAEVNSILDSLFKDPSASPETSRFYK--QLKQSRRVQPEFHVTLIH-RASKK---EHPELWQRYTKLYKEALAKAP 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2130377892 720 ETFDKNCDriKTKYSIKVTVQSLYWDSKIATLTVKpeLVEVErdgslnTLACCNDIPHITLGILEEGIKPVYSNELLKMM 799
Cdd:pfam08302 154 SKSPTSAE--PTLGSCDVRLERLVWDDRIMAIVVR--LVPPE------DWECANKVPHITVGTLSPGVKPKESNDLLKRW 223
                         250       260       270
                  ....*....|....*....|....*....|.
gi 2130377892 800 nQNDKESRPANSFCLELAGLEVQIADVYIHL 830
Cdd:pfam08302 224 -LEEGSGGDTGIGELEIPGKPVLEGTVRGVL 253
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH