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Conserved domains on  [gi|616919111|gb|KAH10157|]
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protein essB [Staphylococcus aureus VET1779S]

Protein Classification

similar to ESAT-6 secretion machinery protein EssB( domain architecture ID 10008596)

protein similar to ESAT-6 secretion machinery protein EssB

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
YukC COG4499
ESX protein secretion system component YukC [Intracellular trafficking, secretion, and ...
 8-444 2.38e-167

ESX protein secretion system component YukC [Intracellular trafficking, secretion, and vesicular transport];


:

Pssm-ID: 443585  Cd Length: 435  Bit Score: 477.55  E-value: 2.38e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111   8 KNEMQDMLTPLDAEEAAKTKLRLDMREIPKSSIKPEHFHLMYLLEQHSPYFIDAELTELRDSFQIHYDINDNHTPFDNIK 87
Cdd:COG4499    1 MEEKKKTYLEDQLEYQFKKEDDRWTLTFQKSKIKLKDELELQLLKEISPEFVPKEITVTEDELIITYQPPSNLKSFEDIK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111  88 SFTKNEKLRYLLNIKNLEEVNRTRYTFVLAPDELFFTRDGLPIAKTRGLQNVVDPLPVSEAEFLTRYKALVICAFNEKQS 167
Cdd:COG4499   81 KKDRSSKLRFALNLAQLEEHLNSRLTLILHPENLVFDKNLTPYFLHRGVKESLPPYELDEERFLKEYKALVIALFSKKYS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111 168 FDALVEGNLELHKGTPFETKVIEAATLDLLTAFLDEQYQKQEQDYSQNYAYVRKVGHTVFKWVAIGMTTLSVLLIAFLAF 247
Cdd:COG4499  161 FDELYLGSLETAKLSPFEKKILQAETLEALLEFLEKQYEKELEAKEKNMAKVPKKKWKIFKYLSIGLIALLVPLIIPLVY 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111 248 LYFSVMKHNERIEKGYQAFVKEDYTQVLNTYDDLDGKKLDKEALYIYAKSYIQTnkQGLEKDKKENLLNNVTPNSNKDYL 327
Cdd:COG4499  241 LLFFKQPFQEAYLAANAAFLKNDYSQVITTLEDYDPEKMPYVVKYELAYSYIQT--ESLSEEQKENILNNITLQSDPDYL 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111 328 LYWMELGQGHLDEAINIATYLDDNDITKLALINKLNEIKNNGDLSNDKRSEETKKYNDKLQDILDKEKQVKDEKAKSEEE 407
Cdd:COG4499  319 LYWIYIGRGELDEALDIARYLDDNDLIMYALIKKREQIKNDPDLSGEEREQKLKELEAELDEYLEEYEEAKEEEEEVEEE 398

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 616919111 408 KAKAKDEKLKQQEENEKKQKEQAQKDKEKRQEAERKK 444
Cdd:COG4499  399 EEKAAEEKLKQEEEKEKKEDEEAAKAEKEDKTKETKK 435
 
Name Accession Description Interval E-value
YukC COG4499
ESX protein secretion system component YukC [Intracellular trafficking, secretion, and ...
 8-444 2.38e-167

ESX protein secretion system component YukC [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 443585  Cd Length: 435  Bit Score: 477.55  E-value: 2.38e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111   8 KNEMQDMLTPLDAEEAAKTKLRLDMREIPKSSIKPEHFHLMYLLEQHSPYFIDAELTELRDSFQIHYDINDNHTPFDNIK 87
Cdd:COG4499    1 MEEKKKTYLEDQLEYQFKKEDDRWTLTFQKSKIKLKDELELQLLKEISPEFVPKEITVTEDELIITYQPPSNLKSFEDIK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111  88 SFTKNEKLRYLLNIKNLEEVNRTRYTFVLAPDELFFTRDGLPIAKTRGLQNVVDPLPVSEAEFLTRYKALVICAFNEKQS 167
Cdd:COG4499   81 KKDRSSKLRFALNLAQLEEHLNSRLTLILHPENLVFDKNLTPYFLHRGVKESLPPYELDEERFLKEYKALVIALFSKKYS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111 168 FDALVEGNLELHKGTPFETKVIEAATLDLLTAFLDEQYQKQEQDYSQNYAYVRKVGHTVFKWVAIGMTTLSVLLIAFLAF 247
Cdd:COG4499  161 FDELYLGSLETAKLSPFEKKILQAETLEALLEFLEKQYEKELEAKEKNMAKVPKKKWKIFKYLSIGLIALLVPLIIPLVY 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111 248 LYFSVMKHNERIEKGYQAFVKEDYTQVLNTYDDLDGKKLDKEALYIYAKSYIQTnkQGLEKDKKENLLNNVTPNSNKDYL 327
Cdd:COG4499  241 LLFFKQPFQEAYLAANAAFLKNDYSQVITTLEDYDPEKMPYVVKYELAYSYIQT--ESLSEEQKENILNNITLQSDPDYL 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111 328 LYWMELGQGHLDEAINIATYLDDNDITKLALINKLNEIKNNGDLSNDKRSEETKKYNDKLQDILDKEKQVKDEKAKSEEE 407
Cdd:COG4499  319 LYWIYIGRGELDEALDIARYLDDNDLIMYALIKKREQIKNDPDLSGEEREQKLKELEAELDEYLEEYEEAKEEEEEVEEE 398

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 616919111 408 KAKAKDEKLKQQEENEKKQKEQAQKDKEKRQEAERKK 444
Cdd:COG4499  399 EEKAAEEKLKQEEEKEKKEDEEAAKAEKEDKTKETKK 435
T7_EssB TIGR03926
type VII secretion protein EssB; Members of this family are associated with type VII secretion ...
 10-393 3.09e-154

type VII secretion protein EssB; Members of this family are associated with type VII secretion of WXG100 family targets in the Firmicutes, but not in the Actinobacteria. This protein is designated YukC in Bacillus subtilis and EssB is Staphylococcus aureus. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 188441  Cd Length: 377  Bit Score: 441.74  E-value: 3.09e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111   10 EMQDMLTPLDAEEaaKTKLRLDMreiPKSSIKPEHFHLMYLLEQHSPYFIDAELTELRDSFQIHYDINDNHTPFDNIKSF 89
Cdd:TIGR03926   1 YLEDQLTAQFEKE--KDTYTLTF---QRSKIKLQDLLELELLKQHSPLFVPAEIDEDEDEFVISYQPPPAAKSFESIKKK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111   90 TKNEKLRYLLNIKNLEEVNRTRYTFVLAPDELFFTRDGLPIAKTRGLQNVVDPLPVSEAEFLTRYKALVICAFNEKQSFD 169
Cdd:TIGR03926  76 TRNEKLRLALNLADLEEHLNSRLTFILHPENLVFTKGLTPSIIHRGVKESLPPYELDEERFLKQYKAFIIALFDGKYRFE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111  170 ALVEGNLELHKGTPFETKVIEAATLDLLTAFLDEQYQKQEQDYSQNYAYVRKVGHTVFKWVAIGMTTLSVLLIAFLAFLY 249
Cdd:TIGR03926 156 ELYNGSLETLKLSPFAKKILEAETLDALLAFLDEQYIKEEEKKEKTLAFVPKKKWRIFKYIGIGLIILLVPLIIPLIYLL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111  250 FSVMKHNERIEKGYQAFVKEDYTQVLNTYDDLDGKKLDKEALYIYAKSYIQTNKqgLEKDKKENLLNNVTPNSNKDYLLY 329
Cdd:TIGR03926 236 FFAQPKQEAILAANTAFLKDDYSQVITTLEDYSPEKLPKSVKYELAYSYVQTEK--LSEDQKENILNNVTLKSDELYLLY 313

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 616919111  330 WMELGQGHLDEAINIATYLDDNDITKLALINKLNEIKNNGDLSNDKRSEETKKYNDKLQDILDK 393
Cdd:TIGR03926 314 WIYIGRGEFEEALDIAKYLDDNDLIMYALVKYREQVKNDTDLSGDERQEKLDELEKELDEYLKK 377
YukC pfam10140
WXG100 protein secretion system (Wss), protein YukC; Members of this family of proteins ...
 35-393 3.50e-142

WXG100 protein secretion system (Wss), protein YukC; Members of this family of proteins include predicted membrane proteins homologous to YukC in B. subtilis. The YukC protein family would participate to the formation of a translocon required for the secretion of WXG100 proteins (pfam06013) in monoderm bacteria, the WXG100 protein secretion system (Wss). This family includes EssB in Staphylococcus aureus.


Pssm-ID: 431082  Cd Length: 357  Bit Score: 410.50  E-value: 3.50e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111   35 IPKSSIKPEHFHLMYLLEQHSPYFIDAELTELRDSFQIHYDINDNHTPFDNIKSFTKNEKLRYLLNIKNLEEVNRTRYTF 114
Cdd:pfam10140   1 FQKSKIKLKNELEAELLKKENPLFLPKEITETEDEVQITYQPPPNYLPFSEIKKKDLNEKLRFALNIAALEEHLSSRYHF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111  115 VLAPDELFFTRDGLPIAKTRGLQNVVDPLPVSEAEFLTRYKALVICAFNEKQSFDALVEGNLELHKGTPFETKVIEAATL 194
Cdd:pfam10140  81 ILHPENLVFDKNLTPYILHRGIKESLPPYETDEEEFLTEYKALIIALFDKKYSFDDYYNGSLTLAKLSPFAKKILEAKTL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111  195 DLLTAFLDEQYQKQEQDYSQNYAYVRKVGHTVFKWVAIGMTTLSVLLIAFLAFLYFSVMKHNERIEKGYQAFVKEDYTQV 274
Cdd:pfam10140 161 EELRAFLQEEYQEEEAKTEKNYIKVPKKKWKIQKYIGIGLIVLLIPLLIYLIYLLFFVQPKQEAIIAANRAFLKKDYSQV 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111  275 LNTYDDLDGKKLDKEALYIYAKSYIQTNKqgLEKDKKENLLNNVTPNSNKDYLLYWMELGQGHLDEAINIATYLDDNDIT 354
Cdd:pfam10140 241 IDTLEKYDPEKMPKVVKYELAYSYVQTEN--LSDDQKENILNNLTLQSDEDYLLYWIYIGRGEFEEALDIAKRLDDNDLI 318

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 616919111  355 KLALINKLNEIKNNGDLSNDKRSEETKKYNDKLQDILDK 393
Cdd:pfam10140 319 MYALLKYREQIKNDDSLSGEEREKELKKLQKEIDEYSKE 357
PTZ00121 PTZ00121
MAEBL; Provisional
 359-444 3.95e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.29  E-value: 3.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111  359 INKLNEIKNNGDLSNDKRSEETKKYNDKLQDilDKEKQVKDEKAKSEEEKAKAKDEKLKQQEENEKKQKEQAQKDKEKRQ 438
Cdd:PTZ00121 1625 LKKAEEEKKKVEQLKKKEAEEKKKAEELKKA--EEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAK 1702


                  ....*.
gi 616919111  439 EAERKK 444
Cdd:PTZ00121 1703 KAEELK 1708
RND_1 NF037998
protein translocase SecDF, variant type; Members of this family are identified by TCDB as ...
 342-432 6.55e-03

protein translocase SecDF, variant type; Members of this family are identified by TCDB as belonging to 2.A.6.4.4, a variant 12-TM type SecDF, as found in Spiroplasma, Mesoplasma, and Acholeplasma.


Pssm-ID: 468306  Cd Length: 1237  Bit Score: 38.99  E-value: 6.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111  342 INIATYLDDNDITKLAliNKLNEIKNNGDLSNdKRSEETKKYNDKLQDILDKEKQVKDEKAKSEEEKAKAKDEKLKQQEE 421
Cdd:NF037998  618 ANQGVAILNYKISRLE--NKIEKLTNKEKLSS-KLLLKIKKINDKIDLLKKKEENKEAKKNAKLIEKVKAKIKKLEQKIT 694

                          90
                  ....*....|.
gi 616919111  422 NEKKQKEQAQK 432
Cdd:NF037998  695 KLKLNKKKSNK 705
 
Name Accession Description Interval E-value
YukC COG4499
ESX protein secretion system component YukC [Intracellular trafficking, secretion, and ...
 8-444 2.38e-167

ESX protein secretion system component YukC [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 443585  Cd Length: 435  Bit Score: 477.55  E-value: 2.38e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111   8 KNEMQDMLTPLDAEEAAKTKLRLDMREIPKSSIKPEHFHLMYLLEQHSPYFIDAELTELRDSFQIHYDINDNHTPFDNIK 87
Cdd:COG4499    1 MEEKKKTYLEDQLEYQFKKEDDRWTLTFQKSKIKLKDELELQLLKEISPEFVPKEITVTEDELIITYQPPSNLKSFEDIK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111  88 SFTKNEKLRYLLNIKNLEEVNRTRYTFVLAPDELFFTRDGLPIAKTRGLQNVVDPLPVSEAEFLTRYKALVICAFNEKQS 167
Cdd:COG4499   81 KKDRSSKLRFALNLAQLEEHLNSRLTLILHPENLVFDKNLTPYFLHRGVKESLPPYELDEERFLKEYKALVIALFSKKYS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111 168 FDALVEGNLELHKGTPFETKVIEAATLDLLTAFLDEQYQKQEQDYSQNYAYVRKVGHTVFKWVAIGMTTLSVLLIAFLAF 247
Cdd:COG4499  161 FDELYLGSLETAKLSPFEKKILQAETLEALLEFLEKQYEKELEAKEKNMAKVPKKKWKIFKYLSIGLIALLVPLIIPLVY 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111 248 LYFSVMKHNERIEKGYQAFVKEDYTQVLNTYDDLDGKKLDKEALYIYAKSYIQTnkQGLEKDKKENLLNNVTPNSNKDYL 327
Cdd:COG4499  241 LLFFKQPFQEAYLAANAAFLKNDYSQVITTLEDYDPEKMPYVVKYELAYSYIQT--ESLSEEQKENILNNITLQSDPDYL 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111 328 LYWMELGQGHLDEAINIATYLDDNDITKLALINKLNEIKNNGDLSNDKRSEETKKYNDKLQDILDKEKQVKDEKAKSEEE 407
Cdd:COG4499  319 LYWIYIGRGELDEALDIARYLDDNDLIMYALIKKREQIKNDPDLSGEEREQKLKELEAELDEYLEEYEEAKEEEEEVEEE 398

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 616919111 408 KAKAKDEKLKQQEENEKKQKEQAQKDKEKRQEAERKK 444
Cdd:COG4499  399 EEKAAEEKLKQEEEKEKKEDEEAAKAEKEDKTKETKK 435
T7_EssB TIGR03926
type VII secretion protein EssB; Members of this family are associated with type VII secretion ...
 10-393 3.09e-154

type VII secretion protein EssB; Members of this family are associated with type VII secretion of WXG100 family targets in the Firmicutes, but not in the Actinobacteria. This protein is designated YukC in Bacillus subtilis and EssB is Staphylococcus aureus. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 188441  Cd Length: 377  Bit Score: 441.74  E-value: 3.09e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111   10 EMQDMLTPLDAEEaaKTKLRLDMreiPKSSIKPEHFHLMYLLEQHSPYFIDAELTELRDSFQIHYDINDNHTPFDNIKSF 89
Cdd:TIGR03926   1 YLEDQLTAQFEKE--KDTYTLTF---QRSKIKLQDLLELELLKQHSPLFVPAEIDEDEDEFVISYQPPPAAKSFESIKKK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111   90 TKNEKLRYLLNIKNLEEVNRTRYTFVLAPDELFFTRDGLPIAKTRGLQNVVDPLPVSEAEFLTRYKALVICAFNEKQSFD 169
Cdd:TIGR03926  76 TRNEKLRLALNLADLEEHLNSRLTFILHPENLVFTKGLTPSIIHRGVKESLPPYELDEERFLKQYKAFIIALFDGKYRFE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111  170 ALVEGNLELHKGTPFETKVIEAATLDLLTAFLDEQYQKQEQDYSQNYAYVRKVGHTVFKWVAIGMTTLSVLLIAFLAFLY 249
Cdd:TIGR03926 156 ELYNGSLETLKLSPFAKKILEAETLDALLAFLDEQYIKEEEKKEKTLAFVPKKKWRIFKYIGIGLIILLVPLIIPLIYLL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111  250 FSVMKHNERIEKGYQAFVKEDYTQVLNTYDDLDGKKLDKEALYIYAKSYIQTNKqgLEKDKKENLLNNVTPNSNKDYLLY 329
Cdd:TIGR03926 236 FFAQPKQEAILAANTAFLKDDYSQVITTLEDYSPEKLPKSVKYELAYSYVQTEK--LSEDQKENILNNVTLKSDELYLLY 313

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 616919111  330 WMELGQGHLDEAINIATYLDDNDITKLALINKLNEIKNNGDLSNDKRSEETKKYNDKLQDILDK 393
Cdd:TIGR03926 314 WIYIGRGEFEEALDIAKYLDDNDLIMYALVKYREQVKNDTDLSGDERQEKLDELEKELDEYLKK 377
YukC pfam10140
WXG100 protein secretion system (Wss), protein YukC; Members of this family of proteins ...
 35-393 3.50e-142

WXG100 protein secretion system (Wss), protein YukC; Members of this family of proteins include predicted membrane proteins homologous to YukC in B. subtilis. The YukC protein family would participate to the formation of a translocon required for the secretion of WXG100 proteins (pfam06013) in monoderm bacteria, the WXG100 protein secretion system (Wss). This family includes EssB in Staphylococcus aureus.


Pssm-ID: 431082  Cd Length: 357  Bit Score: 410.50  E-value: 3.50e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111   35 IPKSSIKPEHFHLMYLLEQHSPYFIDAELTELRDSFQIHYDINDNHTPFDNIKSFTKNEKLRYLLNIKNLEEVNRTRYTF 114
Cdd:pfam10140   1 FQKSKIKLKNELEAELLKKENPLFLPKEITETEDEVQITYQPPPNYLPFSEIKKKDLNEKLRFALNIAALEEHLSSRYHF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111  115 VLAPDELFFTRDGLPIAKTRGLQNVVDPLPVSEAEFLTRYKALVICAFNEKQSFDALVEGNLELHKGTPFETKVIEAATL 194
Cdd:pfam10140  81 ILHPENLVFDKNLTPYILHRGIKESLPPYETDEEEFLTEYKALIIALFDKKYSFDDYYNGSLTLAKLSPFAKKILEAKTL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111  195 DLLTAFLDEQYQKQEQDYSQNYAYVRKVGHTVFKWVAIGMTTLSVLLIAFLAFLYFSVMKHNERIEKGYQAFVKEDYTQV 274
Cdd:pfam10140 161 EELRAFLQEEYQEEEAKTEKNYIKVPKKKWKIQKYIGIGLIVLLIPLLIYLIYLLFFVQPKQEAIIAANRAFLKKDYSQV 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111  275 LNTYDDLDGKKLDKEALYIYAKSYIQTNKqgLEKDKKENLLNNVTPNSNKDYLLYWMELGQGHLDEAINIATYLDDNDIT 354
Cdd:pfam10140 241 IDTLEKYDPEKMPKVVKYELAYSYVQTEN--LSDDQKENILNNLTLQSDEDYLLYWIYIGRGEFEEALDIAKRLDDNDLI 318

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 616919111  355 KLALINKLNEIKNNGDLSNDKRSEETKKYNDKLQDILDK 393
Cdd:pfam10140 319 MYALLKYREQIKNDDSLSGEEREKELKKLQKEIDEYSKE 357
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 376-444 2.30e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 46.66  E-value: 2.30e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 616919111  376 RSEETKKYNDKLQdILDKEKQVKDEKAKSEEEKAKAKDEKLKQQEENEKKQKEQAQKDKEKRQEAERKK 444
Cdd:pfam17380 426 RAEQEEARQREVR-RLEEERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQR 493
PTZ00121 PTZ00121
MAEBL; Provisional
 359-444 3.95e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.29  E-value: 3.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111  359 INKLNEIKNNGDLSNDKRSEETKKYNDKLQDilDKEKQVKDEKAKSEEEKAKAKDEKLKQQEENEKKQKEQAQKDKEKRQ 438
Cdd:PTZ00121 1625 LKKAEEEKKKVEQLKKKEAEEKKKAEELKKA--EEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAK 1702


                  ....*.
gi 616919111  439 EAERKK 444
Cdd:PTZ00121 1703 KAEELK 1708
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 375-444 5.97e-05

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 44.84  E-value: 5.97e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 616919111  375 KRSEETKKYNDKLQDILDKEKQVKDEKAKSEEEKAKA--------KDEKLKQQEENEKKQKEQAQKdKEKRQEAERKK 444
Cdd:TIGR02794  99 AAEKAAKQAEQAAKQAEEKQKQAEEAKAKQAAEAKAKaeaeaerkAKEEAAKQAEEEAKAKAAAEA-KKKAEEAKKKA 175
PTZ00121 PTZ00121
MAEBL; Provisional
 375-444 6.44e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.52  E-value: 6.44e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111  375 KRSEETKKYNDKLQDILDKEKQvKDEKAKSEEEKAKAKDEKLKQQEENEKKQKEQAQKDKEKRQEAERKK 444
Cdd:PTZ00121 1695 KKEAEEAKKAEELKKKEAEEKK-KAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLK 1763
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 393-443 7.31e-05

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 44.84  E-value: 7.31e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 616919111  393 KEKQVKDEKAKSEEEKAKAKDEKLKQQEEN------EKKQKEQAQKDKEKRQEAERK 443
Cdd:TIGR02794  95 EQRAAAEKAAKQAEQAAKQAEEKQKQAEEAkakqaaEAKAKAEAEAERKAKEEAAKQ 151
PTZ00121 PTZ00121
MAEBL; Provisional
 372-444 8.27e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.13  E-value: 8.27e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 616919111  372 SNDKRSEETKKYNDKLQDILDKEKQVKDEKAKSEEEKAKAkdEKLKQQEENEKKQKEQAQKDKEKRQEAERKK 444
Cdd:PTZ00121 1368 AAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKA--DELKKAAAAKKKADEAKKKAEEKKKADEAKK 1438
PTZ00121 PTZ00121
MAEBL; Provisional
 375-444 9.32e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.13  E-value: 9.32e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 616919111  375 KRSEETKKYNDKLQDILDkEKQVKDEKAKSEEEKAKAKDEKLKQQEENEKKQKEQAQK--DKEKRQEAERKK 444
Cdd:PTZ00121 1322 KKAEEAKKKADAAKKKAE-EAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKkaDAAKKKAEEKKK 1392
Cgr1 pfam03879
Cgr1 family; Members of this family are coiled-coil proteins that are involved in pre-rRNA ...
 366-444 6.08e-04

Cgr1 family; Members of this family are coiled-coil proteins that are involved in pre-rRNA processing.


Pssm-ID: 427562 [Multi-domain]  Cd Length: 107  Bit Score: 39.14  E-value: 6.08e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 616919111  366 KNNGDLSNDKRSEETKKYNDKLQDILDKEKQVKDEKAKSEEEKAKAKDEKLKQQEENEKKQKEqAQKDKEKRQEAERKK 444
Cdd:pfam03879  21 SSLVVGPKSKSWEKRQEKRLELKAIKAKEKELKDEKEAERQRRIQAIKERREAKEEKERYEEL-AAKMHAKKVERLKRK 98
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 375-444 6.51e-04

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 41.72  E-value: 6.51e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 616919111 375 KRSEETKKYNDKLQDILDKEKQVKDEKAKsEEEKAKAK-DEKLKQQEENEKKQKEQAQK----DKEKRQEAERKK 444
Cdd:PRK09510 112 AAQEQKKQAEEAAKQAALKQKQAEEAAAK-AAAAAKAKaEAEAKRAAAAAKKAAAEAKKkaeaEAAKKAAAEAKK 185
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 391-444 7.90e-04

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 41.72  E-value: 7.90e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 616919111 391 LDKEKQVKDEKAKSEEEKAKAKDEKLKQQEENEKKQKEQAQ---KDKEKRQEAERKK 444
Cdd:PRK09510 106 LEKERLAAQEQKKQAEEAAKQAALKQKQAEEAAAKAAAAAKakaEAEAKRAAAAAKK 162
PTZ00121 PTZ00121
MAEBL; Provisional
 375-444 7.97e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.05  E-value: 7.97e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 616919111  375 KRSEETKKYNDKLQDILDKEKQVKDEKAKSEEEKAKAKDEKLKQQE----ENEKKQKEQAQKDKEKRQEAERKK 444
Cdd:PTZ00121 1384 KKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEkkkaDEAKKKAEEAKKADEAKKKAEEAK 1457
PTZ00121 PTZ00121
MAEBL; Provisional
 355-444 9.55e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.67  E-value: 9.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111  355 KLALINKLNEIKNNGDLSNDKRSEETKKYNDKLQDILDKEKQVKDEKAKSEEEKAKAKDEKlKQQEENEKKQKEQAQKDK 434
Cdd:PTZ00121 1593 RIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELK-KAEEENKIKAAEEAKKAE 1671

                          90
                  ....*....|
gi 616919111  435 EKRQEAERKK 444
Cdd:PTZ00121 1672 EDKKKAEEAK 1681
CCDC47 pfam07946
PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of ...
 377-444 1.16e-03

PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex, formed by CCDC47 and Asterix proteins, acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. CCDC47 is required to maintain the stability of Asterix. CCDC47 is associated with various membrane-associated processes and is component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. It is also involved in the regulation of calcium ion homeostasis in the ER, being also required for proper protein degradation via the ERAD (ER-associated degradation) pathway.


Pssm-ID: 462322  Cd Length: 323  Bit Score: 40.63  E-value: 1.16e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111  377 SEETKKYNDKLQDILDKE--KQVKDEKAkseeEKAKAKDEKLKQQEENEKKQKEQAQKdKEKRQEAERKK 444
Cdd:pfam07946 255 RPEALKKAKKTREEEIEKikKAAEEERA----EEAQEKKEEAKKKEREEKLAKLSPEE-QRKYEEKERKK 319
PRK12704 PRK12704
phosphodiesterase; Provisional
 351-442 1.16e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 41.30  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111 351 NDITKLALINKLNEIKNngdlsndKRSEETKKYNDKLQDILDKEKQV---------KDEKAKSEEEKAKAKDEKLKQQEE 421
Cdd:PRK12704  52 EAIKKEALLEAKEEIHK-------LRNEFEKELRERRNELQKLEKRLlqkeenldrKLELLEKREEELEKKEKELEQKQQ 124

                         90       100
                 ....*....|....*....|..
gi 616919111 422 N-EKKQKEQAQKDKEKRQEAER 442
Cdd:PRK12704 125 ElEKKEEELEELIEEQLQELER 146
PTZ00121 PTZ00121
MAEBL; Provisional
 375-444 1.19e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.67  E-value: 1.19e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 616919111  375 KRSEETKKYNDKLQDILDkEKQVKDEKAKSEEEKAKAKDEKLKQQE----ENEKKQKEQAQKDKEKRQEAERKK 444
Cdd:PTZ00121 1411 KKAAAAKKKADEAKKKAE-EKKKADEAKKKAEEAKKADEAKKKAEEakkaEEAKKKAEEAKKADEAKKKAEEAK 1483
PTZ00121 PTZ00121
MAEBL; Provisional
 375-444 1.31e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.28  E-value: 1.31e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 616919111  375 KRSEETKKYNDKLQDILDKEKQVKDEKAKSEEEKAKA----KDEKLKQQEENEKKQKEQAQKDKEKRQEAERKK 444
Cdd:PTZ00121 1391 KKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAeekkKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKK 1464
PTZ00121 PTZ00121
MAEBL; Provisional
 373-444 1.43e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.28  E-value: 1.43e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 616919111  373 NDKRSEETKKYNDKLQDILDKEKQVKDEKAKSEEEKAKAkdEKLKQQEEnEKKQKEQAQKDKEKRQEAERKK 444
Cdd:PTZ00121 1461 EAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKA--DEAKKAAE-AKKKADEAKKAEEAKKADEAKK 1529
PTZ00121 PTZ00121
MAEBL; Provisional
 361-444 1.91e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 1.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111  361 KLNEIKNNGDLSNdKRSEETKKYndklqdilDKEKQVKDEKAKSEEEKAKAKDEKLKQQEENEKKQKEQAQKDKEKRQEA 440
Cdd:PTZ00121 1323 KAEEAKKKADAAK-KKAEEAKKA--------AEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKA 1393


                  ....
gi 616919111  441 ERKK 444
Cdd:PTZ00121 1394 DEAK 1397
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 375-444 1.95e-03

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 38.87  E-value: 1.95e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 616919111  375 KRSEETKKYNDKLQDILDKEKQVKDEKAKSEEEKAKAKDEKLKQQEENEKKQKEQAQKDKEK-----RQEAERKK 444
Cdd:pfam05672  44 RKEELRRRAEEERARREEEARRLEEERRREEEERQRKAEEEAEEREQREQEEQERLQKQKEEaeakaREEAERQR 118
PTZ00121 PTZ00121
MAEBL; Provisional
 375-444 2.35e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.51  E-value: 2.35e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111  375 KRSEETKKYNDKLQDiLDKEKQVKDEKAKSEEEKAKAKDEKLKQQEEnEKKQKEQAQKDKEKRQEAERKK 444
Cdd:PTZ00121 1709 KKEAEEKKKAEELKK-AEEENKIKAEEAKKEAEEDKKKAEEAKKDEE-EKKKIAHLKKEEEKKAEEIRKE 1776
PTZ00121 PTZ00121
MAEBL; Provisional
 375-444 2.41e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.51  E-value: 2.41e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 616919111  375 KRSEETKKYNDK----LQDILDKEKQVKDEKAKSEEEkAKAKDEKLKQQEENEKKQKEQAQKDKEKRQEAERKK 444
Cdd:PTZ00121 1581 RKAEEAKKAEEArieeVMKLYEEEKKMKAEEAKKAEE-AKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELK 1653
PTZ00121 PTZ00121
MAEBL; Provisional
 375-444 3.43e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.12  E-value: 3.43e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 616919111  375 KRSEETKKYnDKLQDILDKEKQVKDEKAKSEEEKAKAKDEKLKQQEEN---------EKKQKEQAQKDKEKRQEAERKK 444
Cdd:PTZ00121 1296 KKAEEKKKA-DEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKkaaeaakaeAEAAADEAEAAEEKAEAAEKKK 1373
PTZ00121 PTZ00121
MAEBL; Provisional
 357-444 3.67e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.12  E-value: 3.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111  357 ALINKLNEIKNNGDLSndKRSEETKKYNDKLQDI------LDKEKQVKDEKAKSEEEKAKA----KDEKLKQQEENEKKQ 426
Cdd:PTZ00121 1382 AAKKKAEEKKKADEAK--KKAEEDKKKADELKKAaaakkkADEAKKKAEEKKKADEAKKKAeeakKADEAKKKAEEAKKA 1459

                          90
                  ....*....|....*...
gi 616919111  427 KEQAQKDKEKRQEAERKK 444
Cdd:PTZ00121 1460 EEAKKKAEEAKKADEAKK 1477
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 395-443 3.73e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 39.44  E-value: 3.73e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 616919111  395 KQVKDEKAKSEEEKAKAKDEKLKQQEENEKKQKEQAQKDKEKRQEAERK 443
Cdd:TIGR02794 180 KAKAEAEAKAKAEEAKAKAEAAKAKAAAEAAAKAEAEAAAAAAAEAERK 228
PTZ00121 PTZ00121
MAEBL; Provisional
 375-444 3.73e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.74  E-value: 3.73e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 616919111  375 KRSEETKKYNDKLQDILD--KEKQVKDEKAKSEEEK----AKAKDEKLKQQEENEKKQKEQAQKDKE-KRQEAERKK 444
Cdd:PTZ00121 1343 KAAEAAKAEAEAAADEAEaaEEKAEAAEKKKEEAKKkadaAKKKAEEKKKADEAKKKAEEDKKKADElKKAAAAKKK 1419
PTZ00121 PTZ00121
MAEBL; Provisional
 375-444 3.86e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.74  E-value: 3.86e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 616919111  375 KRSEETKKYND--KLQDILDKEKQVKDEKAKSEEEKAKAKDEKLKQQEENEKKQKEQAQKDKEKRQEAERKK 444
Cdd:PTZ00121 1278 RKADELKKAEEkkKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAK 1349
PTZ00121 PTZ00121
MAEBL; Provisional
 359-444 4.14e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.74  E-value: 4.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111  359 INKLNEIKNNGDLSNDKRSEETKKYNDKLQDILDKEKQVKDEKAKSE----EEKAKAKDEKLKQQEENEKKQKEQAQKDK 434
Cdd:PTZ00121 1646 KKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEalkkEAEEAKKAEELKKKEAEEKKKAEELKKAE 1725

                          90
                  ....*....|....*....
gi 616919111  435 E---------KRQEAERKK 444
Cdd:PTZ00121 1726 EenkikaeeaKKEAEEDKK 1744
PTZ00121 PTZ00121
MAEBL; Provisional
 375-444 4.39e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.74  E-value: 4.39e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111  375 KRSEETKKyNDKLQDILDKEKQVKDEKAKSEEEKAKAkdEKLKQQEenEKKQKEQAQKDKEKRQEAERKK 444
Cdd:PTZ00121 1477 KKAEEAKK-ADEAKKKAEEAKKKADEAKKAAEAKKKA--DEAKKAE--EAKKADEAKKAEEAKKADEAKK 1541
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 392-443 4.52e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 39.02  E-value: 4.52e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 616919111 392 DKEKQV-KDEKAKSEE--EKAKAKDEKLKQQEenekKQKEQAQKDKEKRQEAERK 443
Cdd:PRK09510  76 RAEEQRkKKEQQQAEElqQKQAAEQERLKQLE----KERLAAQEQKKQAEEAAKQ 126
RND_1 NF037998
protein translocase SecDF, variant type; Members of this family are identified by TCDB as ...
 342-432 6.55e-03

protein translocase SecDF, variant type; Members of this family are identified by TCDB as belonging to 2.A.6.4.4, a variant 12-TM type SecDF, as found in Spiroplasma, Mesoplasma, and Acholeplasma.


Pssm-ID: 468306  Cd Length: 1237  Bit Score: 38.99  E-value: 6.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111  342 INIATYLDDNDITKLAliNKLNEIKNNGDLSNdKRSEETKKYNDKLQDILDKEKQVKDEKAKSEEEKAKAKDEKLKQQEE 421
Cdd:NF037998  618 ANQGVAILNYKISRLE--NKIEKLTNKEKLSS-KLLLKIKKINDKIDLLKKKEENKEAKKNAKLIEKVKAKIKKLEQKIT 694

                          90
                  ....*....|.
gi 616919111  422 NEKKQKEQAQK 432
Cdd:NF037998  695 KLKLNKKKSNK 705
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 379-443 6.79e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 38.67  E-value: 6.79e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 616919111  379 ETKKYNDKLQDILDKEKQVKDEKAKS-EEEKAKAKDEKLKQQEENEKKQKEQAQKDKE--KRQEAERK 443
Cdd:TIGR02794  58 QKKPAAKKEQERQKKLEQQAEEAEKQrAAEQARQKELEQRAAAEKAAKQAEQAAKQAEekQKQAEEAK 125
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 375-444 7.50e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 38.25  E-value: 7.50e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111 375 KRSEETKKYNDKLQDILDKEKQVKDEKAKSEEEKakakdEKLKQQEEnEKKQKEQAQKDKEKRQEAERKK 444
Cdd:PRK09510  75 KRAEEQRKKKEQQQAEELQQKQAAEQERLKQLEK-----ERLAAQEQ-KKQAEEAAKQAALKQKQAEEAA 138
PTZ00121 PTZ00121
MAEBL; Provisional
 375-444 9.34e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.58  E-value: 9.34e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111  375 KRSEETKKYNDKLQDildKEKQVKDEKAKSEEEKAKAKDEKLKQQEENEKKQKEQAQKDKEKRQEAERKK 444
Cdd:PTZ00121 1451 KKAEEAKKAEEAKKK---AEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKK 1517
PTZ00121 PTZ00121
MAEBL; Provisional
 375-444 9.42e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.58  E-value: 9.42e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616919111  375 KRSEETKKYNDKLQDILDKEKqvKDEKAKSEEEKAKAkdEKLKQQEenEKKQKEQAQKDKEKRQEAERKK 444
Cdd:PTZ00121 1490 KKAEEAKKKADEAKKAAEAKK--KADEAKKAEEAKKA--DEAKKAE--EAKKADEAKKAEEKKKADELKK 1553
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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