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Conserved domains on  [gi|2076552070|gb|KAG8510230|]
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Zinc finger CCCH domain-containing protein 10, partial [Galemys pyrenaicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
 26-411 0e+00

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


:

Pssm-ID: 273105  Cd Length: 390  Bit Score: 658.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070  26 MSGEDEQQEQ--TIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDSMIMEETGKIFKKEKEMKKGIAFPT 103
Cdd:TIGR00495   1 MSGKDEQQEQaySLSNPEVVTKYKMAGEIANNVLKSVVEACSPGAKVVDICEKGDAFIMEETAKIFKKEKEMEKGIAFPT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070 104 SISVNNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVVDVVQGTQVTGRKADVIKAAHLCAEAALRLVK 183
Cdd:TIGR00495  81 CISVNNCVGHFSPLKSDQDYILKEGDVVKIDLGCHIDGFIALVAHTFVVGVAQEEPVTGRKADVIAAAHLAAEAALRLVK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070 184 PGNQNTQVTEAWNKVAHSFNCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAK 263
Cdd:TIGR00495 161 PGNTNTQVTEAINKVAHSYGCTPVEGMLSHQLKQHVIDGEKVIISNPSDSQKKDHDTAEFEENEVYAVDILVSTGEGKAK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070 264 DAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERRFDAMPFTLRAFEDEKKARMGVVECAKHELLQPFNVLYEKEGEFVAQ 343
Cdd:TIGR00495 241 DADQRTTIYKRDPSKTYGLKMKASRAFFSEIERRFDAMPFTLRNFEDEKRARMGLVECVKHELLQPYPVLYEKEGEFVAQ 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2076552070 344 FKFTVLLMPNGPMRITSGPFEPDLYKSEMEVQDAELKALLQSSASRKTQKKKKKKASKTAENATSGET 411
Cdd:TIGR00495 321 FKFTVLLMPNGPMRITSGEFEPDLYKSEMEVQDPEIKALLASPIKRKKQKKKAKKASKTGEAATEGET 388
ZnF_C3H1 smart00356
zinc finger;
669-693 6.31e-05

zinc finger;


:

Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 40.69  E-value: 6.31e-05
                           10        20
                   ....*....|....*....|....*
gi 2076552070  669 KEEVPICRDFLKGDCQRGAKCKFRH 693
Cdd:smart00356   1 KYKTELCKFFKRGYCPRGDRCKFAH 25
ZnF_C3H1 smart00356
zinc finger;
575-597 1.67e-04

zinc finger;


:

Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 39.53  E-value: 1.67e-04
                           10        20
                   ....*....|....*....|...
gi 2076552070  575 AICRDFLRNVCKRGKRCRYRHPD 597
Cdd:smart00356   5 ELCKFFKRGYCPRGDRCKFAHPL 27
 
Name Accession Description Interval E-value
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
 26-411 0e+00

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


Pssm-ID: 273105  Cd Length: 390  Bit Score: 658.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070  26 MSGEDEQQEQ--TIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDSMIMEETGKIFKKEKEMKKGIAFPT 103
Cdd:TIGR00495   1 MSGKDEQQEQaySLSNPEVVTKYKMAGEIANNVLKSVVEACSPGAKVVDICEKGDAFIMEETAKIFKKEKEMEKGIAFPT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070 104 SISVNNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVVDVVQGTQVTGRKADVIKAAHLCAEAALRLVK 183
Cdd:TIGR00495  81 CISVNNCVGHFSPLKSDQDYILKEGDVVKIDLGCHIDGFIALVAHTFVVGVAQEEPVTGRKADVIAAAHLAAEAALRLVK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070 184 PGNQNTQVTEAWNKVAHSFNCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAK 263
Cdd:TIGR00495 161 PGNTNTQVTEAINKVAHSYGCTPVEGMLSHQLKQHVIDGEKVIISNPSDSQKKDHDTAEFEENEVYAVDILVSTGEGKAK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070 264 DAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERRFDAMPFTLRAFEDEKKARMGVVECAKHELLQPFNVLYEKEGEFVAQ 343
Cdd:TIGR00495 241 DADQRTTIYKRDPSKTYGLKMKASRAFFSEIERRFDAMPFTLRNFEDEKRARMGLVECVKHELLQPYPVLYEKEGEFVAQ 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2076552070 344 FKFTVLLMPNGPMRITSGPFEPDLYKSEMEVQDAELKALLQSSASRKTQKKKKKKASKTAENATSGET 411
Cdd:TIGR00495 321 FKFTVLLMPNGPMRITSGEFEPDLYKSEMEVQDPEIKALLASPIKRKKQKKKAKKASKTGEAATEGET 388
PA2G4-like cd01089
Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family ...
 43-359 1.03e-115

Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family members have been implicated in cell cycle control.


Pssm-ID: 238522  Cd Length: 228  Bit Score: 353.94  E-value: 1.03e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070  43 VTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDSMIMEETGKIFKKEKEMKKGIAFPTSISVNNCVCHFSPLKSDQD 122
Cdd:cd01089     1 VTKYKTAGQIANKVLKQVISLCVPGAKVVDLCEKGDKLILEELGKVYKKEKKLEKGIAFPTCISVNNCVCHFSPLKSDAT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070 123 YILKEGDLVKIDLGVHVDGFIANVAHTFVVDVVQGTQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVAHSF 202
Cdd:cd01089    81 YTLKDGDVVKIDLGCHIDGYIAVVAHTIVVGAEAETPVTGKKADVIAAAHYALEAALRLLRPGNQNSDITEAIQKVIVDY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070 203 NCTPIEGMLSHQLKQhvidgektiiqnptdqqkkdhekaefevhevyavdvLVSSGEGKAKdagqrttiykrdpskqygl 282
Cdd:cd01089   161 GCTPVEGVLSHQLKR------------------------------------VVSSGEGKAK------------------- 185

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2076552070 283 kmktsraffseverrfdampftlrafedekkarmgVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNGPMRIT 359
Cdd:cd01089   186 -----------------------------------LVECVKHGLLFPYPVLYEKEGEVVAQFKLTVLLTPNGVTVLT 227
PTZ00053 PTZ00053
methionine aminopeptidase 2; Provisional
 77-354 1.38e-20

methionine aminopeptidase 2; Provisional


Pssm-ID: 240246 [Multi-domain]  Cd Length: 470  Bit Score: 96.32  E-value: 1.38e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070  77 GDSMImEETGKIFKKEKEM------KKGIAFPTSISVNNCVCHFSPLKSDqDYILKEGDLVKIDLGVHVDGFIANVAHTF 150
Cdd:PTZ00053  182 GVKLI-DICERIESKSRELieadglKCGWAFPTGCSLNHCAAHYTPNTGD-KTVLTYDDVCKLDFGTHVNGRIIDCAFTV 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070 151 VVD-----VVQGTQ---VTGrkadvIKAAHLCAeaalRLVKPGNQNTQVTEAW-----NKVahsFNCTPIEGMLSHQLKQ 217
Cdd:PTZ00053  260 AFNpkydpLLQATKdatNTG-----IKEAGIDV----RLSDIGAAIQEVIESYeveikGKT---YPIKSIRNLNGHSIGP 327

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070 218 HVIDGEKTI-IQNPTDQQKkdhekaeFEVHEVYAVDVLVSSGEGKAKDAGQrTTIYKRDPSKQYG-LKMKTSRAFFSEVE 295
Cdd:PTZ00053  328 YIIHGGKSVpIVKGGENTR-------MEEGELFAIETFASTGRGYVNEDLE-CSHYMKDPGAEFVpLRLPKAKQLLKHIN 399

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2076552070 296 RRFDAMPFTLRAFED--EKKARMGVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNG 354
Cdd:PTZ00053  400 TNFGTLAFCRRWLDRlgQDRHLLALKQLVDAGIVNPYPPLCDVRGSYTSQMEHTILLRPTC 460
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 89-199 2.78e-14

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 72.66  E-value: 2.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070  89 FKKEKEMKKGIAFPTSI--SVNNCVCHFSPLksdqDYILKEGDLVKIDLGVHVD-GFIANVAHTFVVDvvqgtQVTGRKA 165
Cdd:pfam00557  37 ARLRRGGARGPAFPPIVasGPNAAIPHYIPN----DRVLKPGDLVLIDVGAEYDgGYCSDITRTFVVG-----KPSPEQR 107

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2076552070 166 DVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVA 199
Cdd:pfam00557 108 ELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVL 141
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
101-213 3.04e-14

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 73.50  E-value: 3.04e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070 101 FPTSI--SVNNCVCHFSPlksdQDYILKEGDLVKIDLGVHVDGFIANVAHTFVVdvvqGTqVTGRKADVIKAAHLCAEAA 178
Cdd:COG0024    62 FPKSIctSVNEVVVHGIP----SDRVLKDGDIVNIDVGAILDGYHGDSARTFVV----GE-VSPEARRLVEVTEEALYAG 132

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2076552070 179 LRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSH 213
Cdd:COG0024   133 IAAAKPGNRLGDIGHAIQSYAESNGYSVVREFVGH 167
ZnF_C3H1 smart00356
zinc finger;
669-693 6.31e-05

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 40.69  E-value: 6.31e-05
                           10        20
                   ....*....|....*....|....*
gi 2076552070  669 KEEVPICRDFLKGDCQRGAKCKFRH 693
Cdd:smart00356   1 KYKTELCKFFKRGYCPRGDRCKFAH 25
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 675-693 1.13e-04

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 39.71  E-value: 1.13e-04
                          10
                  ....*....|....*....
gi 2076552070 675 CRDFLKGDCQRGAKCKFRH 693
Cdd:pfam18345   1 CKFFLKGRCRYGDKCRFAH 19
ZnF_C3H1 smart00356
zinc finger;
575-597 1.67e-04

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 39.53  E-value: 1.67e-04
                           10        20
                   ....*....|....*....|...
gi 2076552070  575 AICRDFLRNVCKRGKRCRYRHPD 597
Cdd:smart00356   5 ELCKFFKRGYCPRGDRCKFAHPL 27
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 577-595 1.11e-03

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 37.01  E-value: 1.11e-03
                          10
                  ....*....|....*....
gi 2076552070 577 CRDFLRNVCKRGKRCRYRH 595
Cdd:pfam18345   1 CKFFLKGRCRYGDKCRFAH 19
 
Name Accession Description Interval E-value
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
 26-411 0e+00

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


Pssm-ID: 273105  Cd Length: 390  Bit Score: 658.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070  26 MSGEDEQQEQ--TIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDSMIMEETGKIFKKEKEMKKGIAFPT 103
Cdd:TIGR00495   1 MSGKDEQQEQaySLSNPEVVTKYKMAGEIANNVLKSVVEACSPGAKVVDICEKGDAFIMEETAKIFKKEKEMEKGIAFPT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070 104 SISVNNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVVDVVQGTQVTGRKADVIKAAHLCAEAALRLVK 183
Cdd:TIGR00495  81 CISVNNCVGHFSPLKSDQDYILKEGDVVKIDLGCHIDGFIALVAHTFVVGVAQEEPVTGRKADVIAAAHLAAEAALRLVK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070 184 PGNQNTQVTEAWNKVAHSFNCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAK 263
Cdd:TIGR00495 161 PGNTNTQVTEAINKVAHSYGCTPVEGMLSHQLKQHVIDGEKVIISNPSDSQKKDHDTAEFEENEVYAVDILVSTGEGKAK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070 264 DAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERRFDAMPFTLRAFEDEKKARMGVVECAKHELLQPFNVLYEKEGEFVAQ 343
Cdd:TIGR00495 241 DADQRTTIYKRDPSKTYGLKMKASRAFFSEIERRFDAMPFTLRNFEDEKRARMGLVECVKHELLQPYPVLYEKEGEFVAQ 320

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2076552070 344 FKFTVLLMPNGPMRITSGPFEPDLYKSEMEVQDAELKALLQSSASRKTQKKKKKKASKTAENATSGET 411
Cdd:TIGR00495 321 FKFTVLLMPNGPMRITSGEFEPDLYKSEMEVQDPEIKALLASPIKRKKQKKKAKKASKTGEAATEGET 388
PA2G4-like cd01089
Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family ...
 43-359 1.03e-115

Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family members have been implicated in cell cycle control.


Pssm-ID: 238522  Cd Length: 228  Bit Score: 353.94  E-value: 1.03e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070  43 VTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDSMIMEETGKIFKKEKEMKKGIAFPTSISVNNCVCHFSPLKSDQD 122
Cdd:cd01089     1 VTKYKTAGQIANKVLKQVISLCVPGAKVVDLCEKGDKLILEELGKVYKKEKKLEKGIAFPTCISVNNCVCHFSPLKSDAT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070 123 YILKEGDLVKIDLGVHVDGFIANVAHTFVVDVVQGTQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVAHSF 202
Cdd:cd01089    81 YTLKDGDVVKIDLGCHIDGYIAVVAHTIVVGAEAETPVTGKKADVIAAAHYALEAALRLLRPGNQNSDITEAIQKVIVDY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070 203 NCTPIEGMLSHQLKQhvidgektiiqnptdqqkkdhekaefevhevyavdvLVSSGEGKAKdagqrttiykrdpskqygl 282
Cdd:cd01089   161 GCTPVEGVLSHQLKR------------------------------------VVSSGEGKAK------------------- 185

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2076552070 283 kmktsraffseverrfdampftlrafedekkarmgVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNGPMRIT 359
Cdd:cd01089   186 -----------------------------------LVECVKHGLLFPYPVLYEKEGEVVAQFKLTVLLTPNGVTVLT 227
MetAP2 cd01088
Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 45-354 3.71e-44

Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238521 [Multi-domain]  Cd Length: 291  Bit Score: 161.65  E-value: 3.71e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070  45 KYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDSMIMEETGkifkkekemkkGIAFPTSISVNNCVCHFSPLKSDqDYI 124
Cdd:cd01088     3 KYREAGEIHRQVRKYAQSLIKPGMTLLEIAEFVENRIRELGA-----------GPAFPVNLSINECAAHYTPNAGD-DTV 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070 125 LKEGDLVKIDLGVHVDGFIANVAhtFVVDVVQGTQvtgrkaDVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVAHSFNC 204
Cdd:cd01088    71 LKEGDVVKLDFGAHVDGYIADSA--FTVDFDPKYD------DLLEAAKEALNAAIKEAGPDVRLGEIGEAIEEVIESYGF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070 205 TPIEGMLSHQLKQHVIDGEKTIiqnPTDqqkKDHEKAEFEVHEVYAVDVLVSSGEGKAKDaGQRTTIYKRDPSKQYGLKM 284
Cdd:cd01088   143 KPIRNLTGHSIERYRLHAGKSI---PNV---KGGEGTRLEEGDVYAIEPFATTGKGYVHD-GPECSIYMLNRDKPLRLPR 215

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2076552070 285 ktSRAFFSEVERRFDAMPFTLRAFED--EKKARMGVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNG 354
Cdd:cd01088   216 --ARKLLDVIYENFGTLPFARRWLDRlgETKLLMALKNLCKAGIVYPYPVLKEISGGYVAQFEHTIIVREDG 285
PTZ00053 PTZ00053
methionine aminopeptidase 2; Provisional
 77-354 1.38e-20

methionine aminopeptidase 2; Provisional


Pssm-ID: 240246 [Multi-domain]  Cd Length: 470  Bit Score: 96.32  E-value: 1.38e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070  77 GDSMImEETGKIFKKEKEM------KKGIAFPTSISVNNCVCHFSPLKSDqDYILKEGDLVKIDLGVHVDGFIANVAHTF 150
Cdd:PTZ00053  182 GVKLI-DICERIESKSRELieadglKCGWAFPTGCSLNHCAAHYTPNTGD-KTVLTYDDVCKLDFGTHVNGRIIDCAFTV 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070 151 VVD-----VVQGTQ---VTGrkadvIKAAHLCAeaalRLVKPGNQNTQVTEAW-----NKVahsFNCTPIEGMLSHQLKQ 217
Cdd:PTZ00053  260 AFNpkydpLLQATKdatNTG-----IKEAGIDV----RLSDIGAAIQEVIESYeveikGKT---YPIKSIRNLNGHSIGP 327

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070 218 HVIDGEKTI-IQNPTDQQKkdhekaeFEVHEVYAVDVLVSSGEGKAKDAGQrTTIYKRDPSKQYG-LKMKTSRAFFSEVE 295
Cdd:PTZ00053  328 YIIHGGKSVpIVKGGENTR-------MEEGELFAIETFASTGRGYVNEDLE-CSHYMKDPGAEFVpLRLPKAKQLLKHIN 399

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2076552070 296 RRFDAMPFTLRAFED--EKKARMGVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNG 354
Cdd:PTZ00053  400 TNFGTLAFCRRWLDRlgQDRHLLALKQLVDAGIVNPYPPLCDVRGSYTSQMEHTILLRPTC 460
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 101-213 4.55e-17

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 81.77  E-value: 4.55e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070 101 FPTSI--SVNNCVCHFSPlksdQDYILKEGDLVKIDLGVHVDGFIANVAHTFVVdvvqGTqVTGRKADVIKAAHLCAEAA 178
Cdd:cd01086    54 FPKSIctSVNEVVCHGIP----DDRVLKDGDIVNIDVGVELDGYHGDSARTFIV----GE-VSEEAKKLVEVTEEALYKG 124

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2076552070 179 LRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSH 213
Cdd:cd01086   125 IEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFGGH 159
PRK05716 PRK05716
methionine aminopeptidase; Validated
 101-213 4.02e-16

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 79.02  E-value: 4.02e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070 101 FPTSI--SVNNCVCHFSPlksdQDYILKEGDLVKIDLGVHVDGFIANVAHTFVVdvvqGTqVTGRKADVIKAAHLCAEAA 178
Cdd:PRK05716   64 FPKSIctSVNEVVCHGIP----SDKVLKEGDIVNIDVTVIKDGYHGDTSRTFGV----GE-ISPEDKRLCEVTKEALYLG 134

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2076552070 179 LRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSH 213
Cdd:PRK05716  135 IAAVKPGARLGDIGHAIQKYAEAEGFSVVREYCGH 169
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 43-206 2.44e-14

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 72.87  E-value: 2.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070  43 VTKYKMGGDIANRVLRSLVEAsssgvsvlslCEKGDSMImEETGKIFKKEKEMKKGIAFPTSISVNN--CVCHFSPlksd 120
Cdd:cd01066     1 IARLRKAAEIAEAAMAAAAEA----------IRPGVTEA-EVAAAIEQALRAAGGYPAGPTIVGSGArtALPHYRP---- 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070 121 QDYILKEGDLVKIDLGVHVDGFIANVAHTFVVDvvqgtQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVAH 200
Cdd:cd01066    66 DDRRLQEGDLVLVDLGGVYDGYHADLTRTFVIG-----EPSDEQRELYEAVREAQEAALAALRPGVTAEEVDAAAREVLE 140


                  ....*.
gi 2076552070 201 SFNCTP 206
Cdd:cd01066   141 EHGLGP 146
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 89-199 2.78e-14

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 72.66  E-value: 2.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070  89 FKKEKEMKKGIAFPTSI--SVNNCVCHFSPLksdqDYILKEGDLVKIDLGVHVD-GFIANVAHTFVVDvvqgtQVTGRKA 165
Cdd:pfam00557  37 ARLRRGGARGPAFPPIVasGPNAAIPHYIPN----DRVLKPGDLVLIDVGAEYDgGYCSDITRTFVVG-----KPSPEQR 107

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2076552070 166 DVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVA 199
Cdd:pfam00557 108 ELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVL 141
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
101-213 3.04e-14

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 73.50  E-value: 3.04e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070 101 FPTSI--SVNNCVCHFSPlksdQDYILKEGDLVKIDLGVHVDGFIANVAHTFVVdvvqGTqVTGRKADVIKAAHLCAEAA 178
Cdd:COG0024    62 FPKSIctSVNEVVVHGIP----SDRVLKDGDIVNIDVGAILDGYHGDSARTFVV----GE-VSPEARRLVEVTEEALYAG 132

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2076552070 179 LRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSH 213
Cdd:COG0024   133 IAAAKPGNRLGDIGHAIQSYAESNGYSVVREFVGH 167
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 101-213 1.18e-11

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 65.83  E-value: 1.18e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070 101 FPTS--ISVNNCVCHFSPlksdQDYILKEGDLVKIDLGVHVDGFIANVAHTFVVDvvqgtQVTGRKADVIKAAHLCAEAA 178
Cdd:TIGR00500  62 FPGSvcISVNEVVIHGIP----DKKVLKDGDIVNIDVGVIYDGYHGDTAKTFLVG-----KISPEAEKLLECTEESLYKA 132

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2076552070 179 LRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSH 213
Cdd:TIGR00500 133 IEEAKPGNRIGEIGAAIQKYAEAKGFSVVREYCGH 167
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 31-213 3.52e-10

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 61.78  E-value: 3.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070  31 EQQEQTIAEDLVVTKYKMGGDIANRVLR---SLVEASSSGVSVLSLCEKgdsmIMEETGKI--FKKEKemkkgiAFPTS- 104
Cdd:PRK12896    4 EGRGMEIKSPRELEKMRKIGRIVATALKemgKAVEPGMTTKELDRIAEK----RLEEHGAIpsPEGYY------GFPGSt 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070 105 -ISVNNCVCHFSPlkSDQdyILKEGDLVKIDLGVHVDGFIANVAHTFVVDvvqgtQVTGRKADVIKAAHLCAEAALRLVK 183
Cdd:PRK12896   74 cISVNEEVAHGIP--GPR--VIKDGDLVNIDVSAYLDGYHGDTGITFAVG-----PVSEEAEKLCRVAEEALWAGIKQVK 144

                         170       180       190
                  ....*....|....*....|....*....|
gi 2076552070 184 PGNQNTQVTEAWNKVAHSFNCTPIEGMLSH 213
Cdd:PRK12896  145 AGRPLNDIGRAIEDFAKKNGYSVVRDLTGH 174
PRK12318 PRK12318
methionyl aminopeptidase;
101-213 2.30e-07

methionyl aminopeptidase;


Pssm-ID: 183434 [Multi-domain]  Cd Length: 291  Bit Score: 53.67  E-value: 2.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070 101 FPTSI--SVNNCVCHFSPlksdQDYILKEGDLVKIDLGVHVDGFIANVAHtfvvdVVQGTQVTGRKADVIKAAHLCAEAA 178
Cdd:PRK12318  104 FPKTIctSLNEVICHGIP----NDIPLKNGDIMNIDVSCIVDGYYGDCSR-----MVMIGEVSEIKKKVCQASLECLNAA 174

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2076552070 179 LRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSH 213
Cdd:PRK12318  175 IAILKPGIPLYEIGEVIENCADKYGFSVVDQFVGH 209
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
92-198 5.82e-06

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 49.43  E-value: 5.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070  92 EKEMKK----GIAFPTSISV--NNCVCHFSPlksdQDYILKEGDLVKIDLGVHVDGFIANVAHTFVVDVVQGTQvtgRKA 165
Cdd:COG0006   114 EAAMRRrgaeGPSFDTIVASgeNAAIPHYTP----TDRPLKPGDLVLIDAGAEYDGYTSDITRTVAVGEPSDEQ---REI 186

                          90       100       110
                  ....*....|....*....|....*....|....
gi 2076552070 166 -DVIKAAHlcaEAALRLVKPGNQNTQVTEAWNKV 198
Cdd:COG0006   187 yEAVLEAQ---EAAIAALKPGVTGGEVDAAARDV 217
ZnF_C3H1 smart00356
zinc finger;
669-693 6.31e-05

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 40.69  E-value: 6.31e-05
                           10        20
                   ....*....|....*....|....*
gi 2076552070  669 KEEVPICRDFLKGDCQRGAKCKFRH 693
Cdd:smart00356   1 KYKTELCKFFKRGYCPRGDRCKFAH 25
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 675-693 1.13e-04

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 39.71  E-value: 1.13e-04
                          10
                  ....*....|....*....
gi 2076552070 675 CRDFLKGDCQRGAKCKFRH 693
Cdd:pfam18345   1 CKFFLKGRCRYGDKCRFAH 19
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 102-215 1.62e-04

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 44.49  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070 102 PTSIS-VNNCVCHFSPLksdqDYILKEGDLVKIDLGVHVDGFIANVAHTFVVDvvqGtQVTGRKADVIKAAHLCAEAALR 180
Cdd:cd01087    50 YIVAAgSNAAILHYVHN----DQPLKDGDLVLIDAGAEYGGYASDITRTFPVN---G-KFTDEQRELYEAVLAAQKAAIA 121

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2076552070 181 LVKPGNQNTQVTEAWNKVAHsfnctpiEGMLSHQL 215
Cdd:cd01087   122 ACKPGVSYEDIHLLAHRVLA-------EGLKELGI 149
ZnF_C3H1 smart00356
zinc finger;
575-597 1.67e-04

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 39.53  E-value: 1.67e-04
                           10        20
                   ....*....|....*....|...
gi 2076552070  575 AICRDFLRNVCKRGKRCRYRHPD 597
Cdd:smart00356   5 ELCKFFKRGYCPRGDRCKFAHPL 27
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 92-185 4.13e-04

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 42.50  E-value: 4.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2076552070  92 EKEMKK----GIAFPTSIS--VNNCVCHFSPlkSDQdyILKEGDLVKIDLGVHVDGFIANVAHTFVVdvvqgtqvtGRKA 165
Cdd:cd01092    36 EYFMRKlgaeGPSFDTIVAsgPNSALPHGVP--SDR--KIEEGDLVLIDFGAIYDGYCSDITRTVAV---------GEPS 102

                          90       100
                  ....*....|....*....|....
gi 2076552070 166 DVIKAAH---LCA-EAALRLVKPG 185
Cdd:cd01092   103 DELKEIYeivLEAqQAAIKAVKPG 126
PRK15173 PRK15173
peptidase; Provisional
 114-185 4.97e-04

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 43.55  E-value: 4.97e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2076552070 114 FSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVVDvvQGTQVTGRKADVIKAAHlcaEAALRLVKPG 185
Cdd:PRK15173  159 FSPKLIPSNTKACSGDLIKFDCGVDVDGYGADIARTFVVG--EPPEITRKIYQTIRTGH---EHMLSMVAPG 225
PRK14575 PRK14575
putative peptidase; Provisional
 114-185 7.17e-04

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 43.16  E-value: 7.17e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2076552070 114 FSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVVDvvQGTQVTGRKADVIKAAHlcaEAALRLVKPG 185
Cdd:PRK14575  242 FSPKLIPSNTKACSGDLIKFDCGVDVDGYGADIARTFVVG--EPPEITRKIYQTIRTGH---EHMLSMVAPG 308
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 577-595 1.11e-03

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 37.01  E-value: 1.11e-03
                          10
                  ....*....|....*....
gi 2076552070 577 CRDFLRNVCKRGKRCRYRH 595
Cdd:pfam18345   1 CKFFLKGRCRYGDKCRFAH 19
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
673-695 1.54e-03

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 36.79  E-value: 1.54e-03
                          10        20
                  ....*....|....*....|....
gi 2076552070 673 PICRDFLK-GDCQRGAKCKFRHLQ 695
Cdd:pfam00642   4 ELCRFFLRtGYCKYGDRCKFAHGQ 27
zf-CCCH_4 pfam18044
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ...
 673-693 9.98e-03

CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.


Pssm-ID: 465626  Cd Length: 22  Bit Score: 34.49  E-value: 9.98e-03
                          10        20
                  ....*....|....*....|.
gi 2076552070 673 PICRDFLKGDCQRGAKCKFRH 693
Cdd:pfam18044   1 RLCRYFQKGGCRYGDNCRFSH 21
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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