SWIB/MDM2 domain found in SWIB/MDM2 homologous proteins; This family includes Schizosaccharomyces pombe upstream activation factor subunit spp27, Saccharomyces cerevisiae upstream activation factor subunit UAF30, Chlamydiae DNA topoisomerase/SWIB domain fusion protein, Arabidopsis thaliana zinc finger CCCH domain-containing proteins, AtC3H19 and AtC3H44, and similar proteins. S. pombe spp27, also termed upstream activation factor 27 KDa subunit (p27), or upstream activation factor 30 KDa subunit (p30), or upstream activation factor subunit uaf30, is a component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. S. cerevisiae UAF30, also termed upstream activation factor 30 KDa subunit (p30), is a non-essential component of the UAF. It seems to play a role in silencing transcription by RNA polymerase II. The SWIB domain found in Chlamydiae DNA topoisomerase may play a role in chromatin condensation-decondensation, which is characteristic of the chlamydial developmental cycle and not found in any other types of bacteria. AtC3H19, also termed protein needed for RDR2-independent DNA methylation (NERD), is a plant-specific GW repeat- and PHD finger-containing protein that plays a central role in integrating RNA silencing and chromatin signals in 21 nt small-interfering RNA (siRNA)-dependent DNA methylation on the cytosine pathway, leading to transcriptional gene silencing of specific sequences. This family also includes many uncharacterized proteins containing two copies of SWIB/MDM2 domain.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2067093212 173 CGVSPELQAIVGQPAMPRTEIVKQLWAYIRKNNLQDPSNKRKIICDDALRLVFETDCTDMFKMNKLLAKHI 243
Cdd:cd10567     1 YKLSPELAAFLGVSELSRTEVVKKLWAYIKENNLQDPKNKREILCDEKLKKVFGKDEVVMFEMNKLLSKHL 71

DNA topoisomerase III; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067093212  99 FALQPQPHHLPDELSFRQPQHPPPQPQHLASQVQPQPSVTKPEAfAPNATPETPKQSTPVGAKRRGGPGGLNKvcGVSPE 178
Cdd:PRK14724  845 FEFEPRESKFPPRKTAAAKAGAASAAFGGTVAVKAAKPAKKAAA-KKVAAKTAAAKTPRKAAKKKAAPPAAGL--KPSAA 921

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2067093212 179 LQAIVGQPAMPRTEIVKQLWAYIRKNNLQDPSNKRKIICDDALRLVFETDCTDMFKMNKLLAKHI 243
Cdd:PRK14724  922 LAAVIGAEPVARPEVIKKLWDYIKANNLQDPADKRAINADAKLRPVFGKDQVTMFELAGIVGKHL 986

N-terminal domain of Kruppel-like factor (KLF) 1, KLF2, KLF4, and similar proteins; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF1, KLF2, KLF4, and similar proteins.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2067093212  43 HKAGFIRDQINLLLRTHAQPPSHPQTHHYHPQPKDHFAFRNHPQFQSTHPQQFPPHFALQPQPHH 107
Cdd:cd22056   227 AGPGALQGRGGRGGPDCHLLHSSHHHHHHHHLQYQYMNAPYPPHYAHQGAPQFHGQYSVFREPMR 291

SWIB/MDM2 domain found in SWIB/MDM2 homologous proteins; This family includes Schizosaccharomyces pombe upstream activation factor subunit spp27, Saccharomyces cerevisiae upstream activation factor subunit UAF30, Chlamydiae DNA topoisomerase/SWIB domain fusion protein, Arabidopsis thaliana zinc finger CCCH domain-containing proteins, AtC3H19 and AtC3H44, and similar proteins. S. pombe spp27, also termed upstream activation factor 27 KDa subunit (p27), or upstream activation factor 30 KDa subunit (p30), or upstream activation factor subunit uaf30, is a component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. S. cerevisiae UAF30, also termed upstream activation factor 30 KDa subunit (p30), is a non-essential component of the UAF. It seems to play a role in silencing transcription by RNA polymerase II. The SWIB domain found in Chlamydiae DNA topoisomerase may play a role in chromatin condensation-decondensation, which is characteristic of the chlamydial developmental cycle and not found in any other types of bacteria. AtC3H19, also termed protein needed for RDR2-independent DNA methylation (NERD), is a plant-specific GW repeat- and PHD finger-containing protein that plays a central role in integrating RNA silencing and chromatin signals in 21 nt small-interfering RNA (siRNA)-dependent DNA methylation on the cytosine pathway, leading to transcriptional gene silencing of specific sequences. This family also includes many uncharacterized proteins containing two copies of SWIB/MDM2 domain.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2067093212 173 CGVSPELQAIVGQPAMPRTEIVKQLWAYIRKNNLQDPSNKRKIICDDALRLVFETDCTDMFKMNKLLAKHI 243
Cdd:cd10567     1 YKLSPELAAFLGVSELSRTEVVKKLWAYIKENNLQDPKNKREILCDEKLKKVFGKDEVVMFEMNKLLSKHL 71

SWIB/MDM2 domain; This family includes the SWIB domain and the MDM2 domain. The p53-associated protein (MDM2) is an inhibitor of the p53 tumour suppressor gene binding the transactivation domain and down regulating the ability of p53 to activate transcription. This family contains the p53 binding domain of MDM2.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2067093212 171 KVCGVSPELQAIVGQPAMPRTEIVKQLWAYIRKNNLQDPSNKRKIICDDALRLVFETDCTDMFKMNKLLAKHI 243
Cdd:pfam02201   1 KPFKLSPELAELLGEEELSRPEVVKALWEYIKENNLQDPEDKREIICDEKLKKLFGGDRVKFFEMPKLLSPHL 73

SWIB/MDM2 domain; This family includes the SWIB domain and the MDM2 domain. The p53-associated protein (MDM2) is an inhibitor of the p53 tumour suppressor gene binding the transactivation domain and down regulating the ability of p53 to activate transcription. This family contains the p53 binding domain of MDM2.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2067093212 276 VVISEALAKFLGSEgrEMLQSEALRRVWEYIKVNSLEDPLNAMVILCDANLRELLGCESISALGIQEMLARH 347
Cdd:pfam02201   3 FKLSPELAELLGEE--ELSRPEVVKALWEYIKENNLQDPEDKREIICDEKLKKLFGGDRVKFFEMPKLLSPH 72

DNA topoisomerase III; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067093212  99 FALQPQPHHLPDELSFRQPQHPPPQPQHLASQVQPQPSVTKPEAfAPNATPETPKQSTPVGAKRRGGPGGLNKvcGVSPE 178
Cdd:PRK14724  845 FEFEPRESKFPPRKTAAAKAGAASAAFGGTVAVKAAKPAKKAAA-KKVAAKTAAAKTPRKAAKKKAAPPAAGL--KPSAA 921

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2067093212 179 LQAIVGQPAMPRTEIVKQLWAYIRKNNLQDPSNKRKIICDDALRLVFETDCTDMFKMNKLLAKHI 243
Cdd:PRK14724  922 LAAVIGAEPVARPEVIKKLWDYIKANNLQDPADKRAINADAKLRPVFGKDQVTMFELAGIVGKHL 986

SWI complex, BAF60b domains;

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2067093212  273 SSAVVISEALAKFLGSEgrEMLQSEALRRVWEYIKVNSLEDPLNAMVILCDANLRELLGCESISALGIQEMLARH 347
Cdd:smart00151   2 TKKVTLSPELAKVLGAP--EMTRTEIIKRLWEYIKEHNLQDPQNKREILCDSKLEQIFGKDRMDMFEMNKLLTPH 74

DNA topoisomerase I/SWI domain fusion protein; Validated

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067093212 240 AKHIIALEPSKESGQAKRLKVDIESTTESSEpgSSAVVISEALAKFLGSEgrEMLQSEALRRVWEYIKVNSLEDPLNAMV 319
Cdd:PRK06319  754 KKKSASTKGKAAKTVKKKSKAKSKKTTKKRA--GPLYTPSPALAAMIGAE--PVGRGEATKKVWDYIKEHGLQSPENKKL 829

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2067093212 320 ILCDANLRELLGCESISALGIQEMLARhHLFK 351
Cdd:PRK06319  830 IIPDSKLQGVIGPDPIDMFQLSKKLSQ-HLIK 860

N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of Kruppel-like factor (KLF)1, KLF2, and KLF4; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domains of an unknown subfamily of KLFs, predominantly found in fish, related to the N-terminal domains of KLF1, KLF2, and KLF4.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2067093212  43 HKAGFIRDQINLLLRTHAQPPSHPQTHHYHPQPKDHFAFRNHPQFQSTHPQQFPPHFALQPQPHH 107
Cdd:cd22056   227 AGPGALQGRGGRGGPDCHLLHSSHHHHHHHHLQYQYMNAPYPPHYAHQGAPQFHGQYSVFREPMR 291

SWIB/MDM2 domain found in SWIB/MDM2 homologous proteins; This family includes Schizosaccharomyces pombe upstream activation factor subunit spp27, Saccharomyces cerevisiae upstream activation factor subunit UAF30, Chlamydiae DNA topoisomerase/SWIB domain fusion protein, Arabidopsis thaliana zinc finger CCCH domain-containing proteins, AtC3H19 and AtC3H44, and similar proteins. S. pombe spp27, also termed upstream activation factor 27 KDa subunit (p27), or upstream activation factor 30 KDa subunit (p30), or upstream activation factor subunit uaf30, is a component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. S. cerevisiae UAF30, also termed upstream activation factor 30 KDa subunit (p30), is a non-essential component of the UAF. It seems to play a role in silencing transcription by RNA polymerase II. The SWIB domain found in Chlamydiae DNA topoisomerase may play a role in chromatin condensation-decondensation, which is characteristic of the chlamydial developmental cycle and not found in any other types of bacteria. AtC3H19, also termed protein needed for RDR2-independent DNA methylation (NERD), is a plant-specific GW repeat- and PHD finger-containing protein that plays a central role in integrating RNA silencing and chromatin signals in 21 nt small-interfering RNA (siRNA)-dependent DNA methylation on the cytosine pathway, leading to transcriptional gene silencing of specific sequences. This family also includes many uncharacterized proteins containing two copies of SWIB/MDM2 domain.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2067093212 173 CGVSPELQAIVGQPAMPRTEIVKQLWAYIRKNNLQDPSNKRKIICDDALRLVFETDCTDMFKMNKLLAKHI 243
Cdd:cd10567     1 YKLSPELAAFLGVSELSRTEVVKKLWAYIKENNLQDPKNKREILCDEKLKKVFGKDEVVMFEMNKLLSKHL 71

SWIB/MDM2 domain; This family includes the SWIB domain and the MDM2 domain. The p53-associated protein (MDM2) is an inhibitor of the p53 tumour suppressor gene binding the transactivation domain and down regulating the ability of p53 to activate transcription. This family contains the p53 binding domain of MDM2.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2067093212 171 KVCGVSPELQAIVGQPAMPRTEIVKQLWAYIRKNNLQDPSNKRKIICDDALRLVFETDCTDMFKMNKLLAKHI 243
Cdd:pfam02201   1 KPFKLSPELAELLGEEELSRPEVVKALWEYIKENNLQDPEDKREIICDEKLKKLFGGDRVKFFEMPKLLSPHL 73

SWIB/MDM2 domain; This family includes the SWIB domain and the MDM2 domain. The p53-associated protein (MDM2) is an inhibitor of the p53 tumour suppressor gene binding the transactivation domain and down regulating the ability of p53 to activate transcription. This family contains the p53 binding domain of MDM2.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2067093212 276 VVISEALAKFLGSEgrEMLQSEALRRVWEYIKVNSLEDPLNAMVILCDANLRELLGCESISALGIQEMLARH 347
Cdd:pfam02201   3 FKLSPELAELLGEE--ELSRPEVVKALWEYIKENNLQDPEDKREIICDEKLKKLFGGDRVKFFEMPKLLSPH 72

DNA topoisomerase III; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067093212  99 FALQPQPHHLPDELSFRQPQHPPPQPQHLASQVQPQPSVTKPEAfAPNATPETPKQSTPVGAKRRGGPGGLNKvcGVSPE 178
Cdd:PRK14724  845 FEFEPRESKFPPRKTAAAKAGAASAAFGGTVAVKAAKPAKKAAA-KKVAAKTAAAKTPRKAAKKKAAPPAAGL--KPSAA 921

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2067093212 179 LQAIVGQPAMPRTEIVKQLWAYIRKNNLQDPSNKRKIICDDALRLVFETDCTDMFKMNKLLAKHI 243
Cdd:PRK14724  922 LAAVIGAEPVARPEVIKKLWDYIKANNLQDPADKRAINADAKLRPVFGKDQVTMFELAGIVGKHL 986

SWIB domain found in the 60 kda subunit of the ATP-dependent SWI/SNF chromatin-remodeling complexes and similar proteins; SWIB domain is a conserved region found within proteins in the SWI/SNF family of complexes. SWI/SNF complex proteins display helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The mammalian complexes are made up of 9-12 proteins called BAFs (BRG1-associated factors), among which the BAF60 subunit serves as a key link between the core complexes and specific transcriptional factors. The BAF60 subunit have at least three members: BAF60a, which is ubiquitous, BAF60b and BAF60c, which are expressed in muscle and pancreatic tissues, respectively. The family also includes Saccharomyces cerevisiae transcription regulatory protein SNF12 and remodel the structure of chromatin complex subunit 6 (RSC6), and Schizosaccharomyces pombe SWI/SNF and RSC complexes subunit SSR3. SNF12, also termed 73-kDa subunit of the SWI/SNF transcriptional regulatory complex, or SWI/SNF complex component SWP73, is involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). RSC6 and SSR3 are components of the RSC, which is involved in transcription regulation and nucleosome positioning. RSC6 is essential for mitotic growth and suppresses formamide sensitivity of the RSC8 mutants.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2067093212 175 VSPELQAIVGQPAMPRTEIVKQLWAYIRKNNLQDPSNKRKIICDDALRLVFETDCTDMFKMNKLLAKHI 243
Cdd:cd10568     1 LSPALAQLLGIKEGTRPNIIYALWQYIKLNKLQDPEDRRLINCDEALKQLFGVERFKFSELPELLNPHL 69

SWIB domain found in the 60 kda subunit of the ATP-dependent SWI/SNF chromatin-remodeling complexes and similar proteins; SWIB domain is a conserved region found within proteins in the SWI/SNF family of complexes. SWI/SNF complex proteins display helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The mammalian complexes are made up of 9-12 proteins called BAFs (BRG1-associated factors), among which the BAF60 subunit serves as a key link between the core complexes and specific transcriptional factors. The BAF60 subunit have at least three members: BAF60a, which is ubiquitous, BAF60b and BAF60c, which are expressed in muscle and pancreatic tissues, respectively. The family also includes Saccharomyces cerevisiae transcription regulatory protein SNF12 and remodel the structure of chromatin complex subunit 6 (RSC6), and Schizosaccharomyces pombe SWI/SNF and RSC complexes subunit SSR3. SNF12, also termed 73-kDa subunit of the SWI/SNF transcriptional regulatory complex, or SWI/SNF complex component SWP73, is involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). RSC6 and SSR3 are components of the RSC, which is involved in transcription regulation and nucleosome positioning. RSC6 is essential for mitotic growth and suppresses formamide sensitivity of the RSC8 mutants.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067093212 278 ISEALAKFLGSEgrEMLQSEALRRVWEYIKVNSLEDPLNAMVILCDANLRELLGCESISALGIQEMLARH 347
Cdd:cd10568     1 LSPALAQLLGIK--EGTRPNIIYALWQYIKLNKLQDPEDRRLINCDEALKQLFGVERFKFSELPELLNPH 68

DEK C terminal domain; DEK is a chromatin associated protein that is linked with cancers and autoimmune disease. This domain is found at the C terminal of DEK and is of clinical importance since it can reverse the characteriztic abnormal DNA-mutagen sensitivity in fibroblasts from ataxia-telangiectasia (A-T) patients. The structure of this domain shows it to be homologous to the E2F/DP transcription factor family. This domain is also found in chitin synthase proteins like Swiss:Q8TF96, and in protein phosphatases such as Swiss:Q6NN85.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2067093212   3 SDQEIAKGVESVLSQADPTVATTyNSVVQQLEAKLGLDLSHKAGFIRDQINLLL 56
Cdd:pfam08766   2 TDEEIREAIREILRTADLETVTK-KQVRKQLEERLGVDLSERKAFINALIDEIL 54

DNA topoisomerase I/SWI domain fusion protein; Validated

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067093212 240 AKHIIALEPSKESGQAKRLKVDIESTTESSEpgSSAVVISEALAKFLGSEgrEMLQSEALRRVWEYIKVNSLEDPLNAMV 319
Cdd:PRK06319  754 KKKSASTKGKAAKTVKKKSKAKSKKTTKKRA--GPLYTPSPALAAMIGAE--PVGRGEATKKVWDYIKEHGLQSPENKKL 829

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2067093212 320 ILCDANLRELLGCESISALGIQEMLARhHLFK 351
Cdd:PRK06319  830 IIPDSKLQGVIGPDPIDMFQLSKKLSQ-HLIK 860

DNA topoisomerase III; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2067093212 249 SKESGQAKRLKVDIESTTESSEPGSSAVVISEALAKFLGSEgrEMLQSEALRRVWEYIKVNSLEDPLNAMVILCDANLRE 328
Cdd:PRK14724  889 KKVAAKTAAAKTPRKAAKKKAAPPAAGLKPSAALAAVIGAE--PVARPEVIKKLWDYIKANNLQDPADKRAINADAKLRP 966

                          90
                  ....*....|....*....
gi 2067093212 329 LLGCESISALGIQEMLARH 347
Cdd:PRK14724  967 VFGKDQVTMFELAGIVGKH 985

SWIB domain found in BRG1-associated factor 60B (BAF60B) and similar proteins; BAF60B, also termed SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 (SMARCD2), or 60 kDa BRG-1/Brm-associated factor subunit B, is a component of the BAF complex. It is involved in transcriptional activation and repression of select genes by chromatin remodeling. It plays a role in the ATM-p53 pathway in sensing chromatin opening by facilitating ATM recruitment to the SWI/SNF complex, as well as ATM activation. It also regulates transcriptional networks controlling differentiation of neutrophil granulocytes. Thus, it acts as a key factor controlling myelopoiesis and is a potential tumor suppressor in leukemia.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2067093212 175 VSPELQAIVGQPAMPRTEIVKQLWAYIRKNNLQDPSNKRKIICDDALRLVF 225
Cdd:cd17675     7 LDPRLARLLGVHTQTRANIMQALWLYIKHNKLQDSHEKEYINCNRYFRQIF 57

N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of Kruppel-like factor (KLF)1, KLF2, and KLF4; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domains of an unknown subfamily of KLFs, predominantly found in fish, related to the N-terminal domains of KLF1, KLF2, and KLF4.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2067093212  43 HKAGFIRDQINLLLRTHAQPPSHPQTHHYHPQPKDHFAFRNHPQFQSTHPQQFPPHFALQPQPHH 107
Cdd:cd22056   227 AGPGALQGRGGRGGPDCHLLHSSHHHHHHHHLQYQYMNAPYPPHYAHQGAPQFHGQYSVFREPMR 291