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Conserved domains on  [gi|2065885258|gb|KAG7648126|]
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Isopropylmalate dehydrogenase [Arabidopsis thaliana x Arabidopsis arenosa]

Protein Classification

3-isopropylmalate dehydrogenase( domain architecture ID 10010765)

3-isopropylmalate dehydrogenase catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 16-419 0e+00

3-isopropylmalate dehydrogenase


:

Pssm-ID: 215188  Cd Length: 409  Bit Score: 793.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  16 MAAFLQTNIRLE---IIPGRYSSLTDHKFRAPYRIRCAAASPVKKRYNITLLPGDGIGPEVISVAKNVLQKAGFLQGLEF 92
Cdd:PLN02329    1 MAAFLQTNIRLNsikIVPGRYSSLTDHQFRAPYRIRCAAASPGKKRYNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  93 DFQEMPFGGAALDLVGVPLPEETSTAAKQSDAILLGAIGGYKWDKNEKHLRPEMGLLNIRRDLNVFANLRPATVLPQLVD 172
Cdd:PLN02329   81 DFQEMPVGGAALDLVGVPLPEETFTAAKQSDAILLGAIGGYKWDKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQLVD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 173 ASTLKKEVAQGVDMMIVRELTGGIYFGEPRGITINENGEEVGFNTEIYAAHEIDRIARVAFETARKRRGKLCSVDKANVL 252
Cdd:PLN02329  161 ASTLKKEVAEGVDMMIVRELTGGIYFGEPRGITINENGEEVGVSTEIYAAHEIDRIARVAFETARKRRGKLCSVDKANVL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 253 DASILWRKRVTALASEYPDVELSHMYVDNAAMQLVRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGL 332
Cdd:PLN02329  241 DASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGL 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 333 FEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKMIEDAVVDALNKGFRTGDIYSPGNKLVGCKEMGEEVLKS 412
Cdd:PLN02329  321 FEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRIEDAVVDALNKGFRTGDIYSPGNKLVGCKEMGEEVLKS 400


                  ....*..
gi 2065885258 413 VDSKVPV 419
Cdd:PLN02329  401 VDSKVPA 407
 
Name Accession Description Interval E-value
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 16-419 0e+00

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 793.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  16 MAAFLQTNIRLE---IIPGRYSSLTDHKFRAPYRIRCAAASPVKKRYNITLLPGDGIGPEVISVAKNVLQKAGFLQGLEF 92
Cdd:PLN02329    1 MAAFLQTNIRLNsikIVPGRYSSLTDHQFRAPYRIRCAAASPGKKRYNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  93 DFQEMPFGGAALDLVGVPLPEETSTAAKQSDAILLGAIGGYKWDKNEKHLRPEMGLLNIRRDLNVFANLRPATVLPQLVD 172
Cdd:PLN02329   81 DFQEMPVGGAALDLVGVPLPEETFTAAKQSDAILLGAIGGYKWDKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQLVD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 173 ASTLKKEVAQGVDMMIVRELTGGIYFGEPRGITINENGEEVGFNTEIYAAHEIDRIARVAFETARKRRGKLCSVDKANVL 252
Cdd:PLN02329  161 ASTLKKEVAEGVDMMIVRELTGGIYFGEPRGITINENGEEVGVSTEIYAAHEIDRIARVAFETARKRRGKLCSVDKANVL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 253 DASILWRKRVTALASEYPDVELSHMYVDNAAMQLVRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGL 332
Cdd:PLN02329  241 DASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGL 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 333 FEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKMIEDAVVDALNKGFRTGDIYSPGNKLVGCKEMGEEVLKS 412
Cdd:PLN02329  321 FEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRIEDAVVDALNKGFRTGDIYSPGNKLVGCKEMGEEVLKS 400


                  ....*..
gi 2065885258 413 VDSKVPV 419
Cdd:PLN02329  401 VDSKVPA 407
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 58-411 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 565.79  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  58 RYNITLLPGDGIGPEVISVAKNVLQKAGFLQGLEFDFQEMPFGGAALDLVGVPLPEETSTAAKQSDAILLGAIGGYKWDK 137
Cdd:COG0473     1 TYKIAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWDD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 138 nekHLRPEMGLLNIRRDLNVFANLRPATVLPQLvdASTLKKEVAQGVDMMIVRELTGGIYFGEPRGITInENGEEVGFNT 217
Cdd:COG0473    81 ---GVRPESGLLALRKELDLYANLRPAKLYPGL--PSPLKPEIVEGIDLVIVRENTEGLYFGIGGRIGT-GTGEEVAIDT 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 218 EIYAAHEIDRIARVAFETARKRRGKLCSVDKANVL-DASILWRKRVTALASEYPDVELSHMYVDNAAMQLVRDPKQFDTI 296
Cdd:COG0473   155 RVYTRKGIERIARYAFELARKRRKKVTSVDKANVLkLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVI 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 297 VTNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAAKMIE 376
Cdd:COG0473   235 VTENLFGDILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRH-LGEEEAADAIE 313

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 2065885258 377 DAVVDALNKGFRTGDIYSPgnklVGCKEMGEEVLK 411
Cdd:COG0473   314 AAVEKVLAEGVRTPDLGGK----AGTSEMGDAIIA 344
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 60-409 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 555.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  60 NITLLPGDGIGPEVISVAKNVLQKAGFLQGLEFDFQEMPFGGAALDLVGVPLPEETSTAAKQSDAILLGAIGGYKWDKNE 139
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 140 KHLRPEMGLLNIRRDLNVFANLRPATVLPQLVDASTLKKEVAQGVDMMIVRELTGGIYFGEPRGItineNGEEVGFNTEI 219
Cdd:TIGR00169  81 RDQRPEQGLLKLRKSLDLFANLRPAKVFPGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKGR----EGEGEAWDTEV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 220 YAAHEIDRIARVAFETARKRRGKLCSVDKANVLDASILWRKRVTALASEYPDVELSHMYVDNAAMQLVRDPKQFDTIVTN 299
Cdd:TIGR00169 157 YTVPEIERIARVAFEMARKRRKKVTSVDKANVLESSRLWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVTS 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 300 NIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKMIEDAV 379
Cdd:TIGR00169 237 NLFGDILSDEASVITGSLGMLPSASLGSDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEEAADAIEAAV 316

                         330       340       350
                  ....*....|....*....|....*....|
gi 2065885258 380 VDALNKGFRTGDIYSPGNKLVGCKEMGEEV 409
Cdd:TIGR00169 317 KKVLAEGYRTPDLGSSATTAVGTAEMGEEL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
60-409 0e+00

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 531.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  60 NITLLPGDGIGPEVISVAKNVLQKAGFLQGLEFDFQEMPFGGAALDLVGVPLPEETSTAAKQSDAILLGAIGGYKWDknE 139
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWD--P 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 140 KHLRPEMGLLNIRRDLNVFANLRPATVLPQLVDASTLKKEVAqGVDMMIVRELTGGIYFGEPRGITinENGEEVGFNTEI 219
Cdd:pfam00180  79 AGVRPENGLLALRKELGLFANLRPAKVFPPLGDASPLKNEVE-GVDIVIVRELTGGIYFGIEKGIK--GSGNEVAVDTKL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 220 YAAHEIDRIARVAFETARKR-RGKLCSVDKANVLDASILWRKRVTALAS-EYPDVELSHMYVDNAAMQLVRDPKQFDTIV 297
Cdd:pfam00180 156 YSRDEIERIARVAFELARKRgRKKVTSVDKANVLKSSDLWRKIVTEVAKaEYPDVELEHQLVDNAAMQLVKNPSQFDVIV 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 298 TNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKMIED 377
Cdd:pfam00180 236 TPNLFGDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDAADKIEA 315

                         330       340       350
                  ....*....|....*....|....*....|..
gi 2065885258 378 AVVDALNKGFRTGDIYSpGNKLVGCKEMGEEV 409
Cdd:pfam00180 316 AVLKVLESGIRTGDLAG-SATYVSTSEFGEAV 346
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
59-416 3.03e-83

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 258.12  E-value: 3.03e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  59 YNITLLPGDGIGPEVISVAKNVLQKAGflqgLEFDFQEMPFGGAALDLVGVPLPEETSTAAKQSDAILLGAIGGYKWDKN 138
Cdd:NF040626    2 YKITVIPGDGIGKEVMEAALYVLDALD----LNFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAVTSTPGQKS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 139 ekhlrpemGLLNIRRDLNVFANLRPatvlpqlVDASTLKKEVAQGVDMMIVRELTGGIYFGEprgitINENGEEVGFNTE 218
Cdd:NF040626   78 --------PIITLRKELDLYANLRP-------IKSYEGINCLFKDLDFLIVRENTEGLYSGL-----EEEYTEEKAIAER 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 219 IYAAHEIDRIARVAFETARKR-RGKLCSVDKANVLDASI-LWRKRVTALASEYPDVELSHMYVDNAAMQLVRDPKQFDTI 296
Cdd:NF040626  138 VITRKASERICKFAFEYAIKLgRKKVTAVHKANVLKKTDgIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDVI 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 297 VTNNIFGDILSDEASMITGSIGMLPSASLGESGpGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAAKMIE 376
Cdd:NF040626  218 VTTNLFGDILSDEAAGLVGGLGLAPSANIGDKN-GLFEPVHGSAPDIAGKNIANPIAMILSASMMLDY-LGETYEANKLE 295

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 2065885258 377 DAVVDALNKG-FRTGDIYSPGNKLvgckEMGEEVLKSVDSK 416
Cdd:NF040626  296 NALEKVLREGkVVTPDLGGNAKTM----EMANEIKKKIEEL 332
AksF_Meth NF040619
homoisocitrate dehydrogenase;
59-409 2.59e-68

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 219.63  E-value: 2.59e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  59 YNITLLPGDGIGPEVISVAKNVLQKAGflqglEFDFQEMPFGGAALDLVGVPLPEETSTAAKQSDAILLGAIGGYKWD-- 136
Cdd:NF040619    2 PKICVIEGDGIGKEVIPETVRVLKELG-----DFEFIKGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPKPTel 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 137 KNEKHLRPemgLLNIRRDLNVFANLRPATVLPQLVDAstlkkevaQGVDMMIVRELTGGIYFGEPRgitINENGEeVGFN 216
Cdd:NF040619   77 KNKNYKSP---ILTLRKELDLYANVRPINNFGDGQDV--------KNIDFVIIRENTEGLYVGREY---YDEENE-IAIA 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 217 TEIYAAHEIDRIARVAFETARK-RRGKLCSVDKANVLDASI-LWRKRVTALASEY--PDVELSHMYVDNAAMQLVRDPKQ 292
Cdd:NF040619  142 ERIISKKGSERIIKFAFEYAKKnNRKKVSCIHKANVLRVTDgLFLEIFNEIKKKYknFNIEADDYLVDATAMYLIKNPEM 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 293 FDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESgPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAA 372
Cdd:NF040619  222 FDVIVTTNLFGDILSDEASGLIGGLGLAPSANIGDK-KGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDY-LGMKEKG 299

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 2065885258 373 KMIEDAVVDALNKGFRTGDIyspGNKLvGCKEMGEEV 409
Cdd:NF040619  300 DLIREAVKKCLENGKVTPDL---GGNL-KTKEVTDKI 332
 
Name Accession Description Interval E-value
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 16-419 0e+00

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 793.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  16 MAAFLQTNIRLE---IIPGRYSSLTDHKFRAPYRIRCAAASPVKKRYNITLLPGDGIGPEVISVAKNVLQKAGFLQGLEF 92
Cdd:PLN02329    1 MAAFLQTNIRLNsikIVPGRYSSLTDHQFRAPYRIRCAAASPGKKRYNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  93 DFQEMPFGGAALDLVGVPLPEETSTAAKQSDAILLGAIGGYKWDKNEKHLRPEMGLLNIRRDLNVFANLRPATVLPQLVD 172
Cdd:PLN02329   81 DFQEMPVGGAALDLVGVPLPEETFTAAKQSDAILLGAIGGYKWDKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQLVD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 173 ASTLKKEVAQGVDMMIVRELTGGIYFGEPRGITINENGEEVGFNTEIYAAHEIDRIARVAFETARKRRGKLCSVDKANVL 252
Cdd:PLN02329  161 ASTLKKEVAEGVDMMIVRELTGGIYFGEPRGITINENGEEVGVSTEIYAAHEIDRIARVAFETARKRRGKLCSVDKANVL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 253 DASILWRKRVTALASEYPDVELSHMYVDNAAMQLVRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGL 332
Cdd:PLN02329  241 DASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGL 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 333 FEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKMIEDAVVDALNKGFRTGDIYSPGNKLVGCKEMGEEVLKS 412
Cdd:PLN02329  321 FEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRIEDAVVDALNKGFRTGDIYSPGNKLVGCKEMGEEVLKS 400


                  ....*..
gi 2065885258 413 VDSKVPV 419
Cdd:PLN02329  401 VDSKVPA 407
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 57-416 0e+00

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 656.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  57 KRYNITLLPGDGIGPEVISVAKNVLQKAGFLQGLEFDFQEMPFGGAALDLVGVPLPEETSTAAKQSDAILLGAIGGYKWD 136
Cdd:PRK00772    1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 137 KNEKHLRPEMGLLNIRRDLNVFANLRPATVLPQLVDASTLKKEVAQGVDMMIVRELTGGIYFGEPRGITInENGEEVGFN 216
Cdd:PRK00772   81 NLPPDVRPERGLLALRKELGLFANLRPAKLYPGLADASPLKPEIVAGLDILIVRELTGGIYFGEPRGREG-LGGEERAFD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 217 TEIYAAHEIDRIARVAFETARKRRGKLCSVDKANVLDASILWRKRVTALASEYPDVELSHMYVDNAAMQLVRDPKQFDTI 296
Cdd:PRK00772  160 TMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDVI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 297 VTNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKMIE 376
Cdd:PRK00772  240 VTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAIE 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 2065885258 377 DAVVDALNKGFRTGDIYsPGNKLVGCKEMGEEVLKSVDSK 416
Cdd:PRK00772  320 AAVEKVLAQGYRTADIA-EGGGKVSTSEMGDAILAALAEG 358
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 58-411 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 565.79  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  58 RYNITLLPGDGIGPEVISVAKNVLQKAGFLQGLEFDFQEMPFGGAALDLVGVPLPEETSTAAKQSDAILLGAIGGYKWDK 137
Cdd:COG0473     1 TYKIAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWDD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 138 nekHLRPEMGLLNIRRDLNVFANLRPATVLPQLvdASTLKKEVAQGVDMMIVRELTGGIYFGEPRGITInENGEEVGFNT 217
Cdd:COG0473    81 ---GVRPESGLLALRKELDLYANLRPAKLYPGL--PSPLKPEIVEGIDLVIVRENTEGLYFGIGGRIGT-GTGEEVAIDT 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 218 EIYAAHEIDRIARVAFETARKRRGKLCSVDKANVL-DASILWRKRVTALASEYPDVELSHMYVDNAAMQLVRDPKQFDTI 296
Cdd:COG0473   155 RVYTRKGIERIARYAFELARKRRKKVTSVDKANVLkLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVI 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 297 VTNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAAKMIE 376
Cdd:COG0473   235 VTENLFGDILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRH-LGEEEAADAIE 313

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 2065885258 377 DAVVDALNKGFRTGDIYSPgnklVGCKEMGEEVLK 411
Cdd:COG0473   314 AAVEKVLAEGVRTPDLGGK----AGTSEMGDAIIA 344
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 60-409 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 555.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  60 NITLLPGDGIGPEVISVAKNVLQKAGFLQGLEFDFQEMPFGGAALDLVGVPLPEETSTAAKQSDAILLGAIGGYKWDKNE 139
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 140 KHLRPEMGLLNIRRDLNVFANLRPATVLPQLVDASTLKKEVAQGVDMMIVRELTGGIYFGEPRGItineNGEEVGFNTEI 219
Cdd:TIGR00169  81 RDQRPEQGLLKLRKSLDLFANLRPAKVFPGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKGR----EGEGEAWDTEV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 220 YAAHEIDRIARVAFETARKRRGKLCSVDKANVLDASILWRKRVTALASEYPDVELSHMYVDNAAMQLVRDPKQFDTIVTN 299
Cdd:TIGR00169 157 YTVPEIERIARVAFEMARKRRKKVTSVDKANVLESSRLWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVTS 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 300 NIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKMIEDAV 379
Cdd:TIGR00169 237 NLFGDILSDEASVITGSLGMLPSASLGSDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEEAADAIEAAV 316

                         330       340       350
                  ....*....|....*....|....*....|
gi 2065885258 380 VDALNKGFRTGDIYSPGNKLVGCKEMGEEV 409
Cdd:TIGR00169 317 KKVLAEGYRTPDLGSSATTAVGTAEMGEEL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
60-409 0e+00

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 531.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  60 NITLLPGDGIGPEVISVAKNVLQKAGFLQGLEFDFQEMPFGGAALDLVGVPLPEETSTAAKQSDAILLGAIGGYKWDknE 139
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWD--P 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 140 KHLRPEMGLLNIRRDLNVFANLRPATVLPQLVDASTLKKEVAqGVDMMIVRELTGGIYFGEPRGITinENGEEVGFNTEI 219
Cdd:pfam00180  79 AGVRPENGLLALRKELGLFANLRPAKVFPPLGDASPLKNEVE-GVDIVIVRELTGGIYFGIEKGIK--GSGNEVAVDTKL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 220 YAAHEIDRIARVAFETARKR-RGKLCSVDKANVLDASILWRKRVTALAS-EYPDVELSHMYVDNAAMQLVRDPKQFDTIV 297
Cdd:pfam00180 156 YSRDEIERIARVAFELARKRgRKKVTSVDKANVLKSSDLWRKIVTEVAKaEYPDVELEHQLVDNAAMQLVKNPSQFDVIV 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 298 TNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKMIED 377
Cdd:pfam00180 236 TPNLFGDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDAADKIEA 315

                         330       340       350
                  ....*....|....*....|....*....|..
gi 2065885258 378 AVVDALNKGFRTGDIYSpGNKLVGCKEMGEEV 409
Cdd:pfam00180 316 AVLKVLESGIRTGDLAG-SATYVSTSEFGEAV 346
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 57-383 5.03e-87

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 268.33  E-value: 5.03e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  57 KRYNITLLPGDGIGPEVISVAKNVLQKAGfLQGLEFDFQEMPFGGAALDLVGVPLPEETSTAAKQSDAILLGAIG--GYK 134
Cdd:PRK03437    3 KTMKLAVIPGDGIGPEVVAEALKVLDAVA-AGGPGVETTEYDLGARRYLRTGETLPDSVLAELRQHDAILLGAIGdpSVP 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 135 WDKNEKHLrpemgLLNIRRDLNVFANLRPATVLPQLvdASTLKKevAQGVDMMIVRELTGGIYFGEP---RGITINENGE 211
Cdd:PRK03437   82 SGVLERGL-----LLKLRFALDHYVNLRPSKLYPGV--TSPLAG--PGDIDFVVVREGTEGPYTGNGgalRVGTPHEVAT 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 212 EVGFNTeiyaAHEIDRIARVAFETARKR-RGKLCSVDKANVL-DASILWRKRVTALASEYPDVELSHMYVDNAAMQLVRD 289
Cdd:PRK03437  153 EVSVNT----AFGVERVVRDAFERAQKRpRKHLTLVHKTNVLtFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMVTD 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 290 PKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESG--PGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLG 367
Cdd:PRK03437  229 PSRFDVIVTDNLFGDIITDLAAAVTGGIGLAASGNINPTGtnPSMFEPVHGSAPDIAGQGIADPTAAILSVALLLDH-LG 307

                         330
                  ....*....|....*.
gi 2065885258 368 EEKAAKMIEDAVVDAL 383
Cdd:PRK03437  308 EEDAAARIEAAVEADL 323
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 59-413 4.82e-86

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 265.46  E-value: 4.82e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  59 YNITLLPGDGIGPEVISVAKNVLQKAGflqgLEFDFQEMPFGGAALDLVGVPLPEETSTAAKQSDAILLGAIGGYKWDKn 138
Cdd:PRK14025    2 HKICVIEGDGIGKEVVPAALHVLEATG----LPFEFVYAEAGDEVFEKTGKALPEETIEAAKEADAVLFGAAGETAADV- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 139 ekhlrpemgLLNIRRDLNVFANLRPATVLPQLvdastlkKEVAQGVDMMIVRELTGGIYFGEPRGItinenGEEVGFNTE 218
Cdd:PRK14025   77 ---------IVKLRRILDTYANVRPVKSYKGV-------KCLYPDIDYVIVRENTEGLYKGIEAEI-----ADGVTVATR 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 219 IYAAHEIDRIARVAFETARKR-----RGKLCSVDKANVLDASI-LWRKRVTALASEYPDVELSHMYVDNAAMQLVRDPKQ 292
Cdd:PRK14025  136 VITRKASERIFRFAFEMAKRRkkmgkEGKVTCAHKANVLKKTDgLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQT 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 293 FDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGpGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAA 372
Cdd:PRK14025  216 FDVVVTSNLFGDILSDGAAGLVGGLGLAPSANIGDKY-GLFEPVHGSAPDIAGKGIANPTATILTAVLMLRH-LGENEEA 293

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 2065885258 373 KMIEDAVVDALNKGFRTGDIyspGNKLvGCKEMGEEVLKSV 413
Cdd:PRK14025  294 DKVEKALEEVLALGLTTPDL---GGNL-STMEMAEEVAKRV 330
TTC TIGR02089
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ...
 56-413 1.42e-84

tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]


Pssm-ID: 273963  Cd Length: 352  Bit Score: 262.46  E-value: 1.42e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  56 KKRYNITLLPGDGIGPEVISVAKNVLQKAGFLQG-LEFDFQEMPFGGAALDLVGVPLPEETSTAAKQSDAILLGAIGGYK 134
Cdd:TIGR02089   1 MKQYRIAAIPGDGIGKEVVAAALQVLEAAAKRHGgFSLHFTEFPWSCDYYKEHGKMMPEDGLEKLKKFDAIFLGAVGWPA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 135 wdKNEKHLRPEMGLLNIRRDLNVFANLRPATVLPQLvdASTLKKEVAQGVDMMIVRELTGGIYfGEPRGITINENGEEVG 214
Cdd:TIGR02089  81 --LVPDHISLWGLLLKIRREFDQYANVRPAKLLPGV--TSPLRNCGPGDFDFVVVRENSEGEY-SGVGGRIHRGTDEEVA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 215 FNTEIYAAHEIDRIARVAFETARKRRGKLCSVDKANVLDASI-LWRKRVTALASEYPDVELSHMYVDNAAMQLVRDPKQF 293
Cdd:TIGR02089 156 TQNAIFTRKGVERIMRFAFELAQKRRKHLTSATKSNGIRHSMpFWDEVFAEVAAEYPDVEWDSYHIDALAARFVLKPETF 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 294 DTIVTNNIFGDILSDEASMITGSIGMLPSASLGESG--PGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKA 371
Cdd:TIGR02089 236 DVIVASNLFGDILSDLGAALMGSLGVAPSANINPEGkfPSMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLEH-LGEKEA 314

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 2065885258 372 AKMIEDAVVDALNKGFRTGDIysPGNKlvGCKEMGEEVLKSV 413
Cdd:TIGR02089 315 GAKIMDAIERVTAAGILTPDV--GGKA--TTSEVTEAVCNAL 352
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
59-416 3.03e-83

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 258.12  E-value: 3.03e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  59 YNITLLPGDGIGPEVISVAKNVLQKAGflqgLEFDFQEMPFGGAALDLVGVPLPEETSTAAKQSDAILLGAIGGYKWDKN 138
Cdd:NF040626    2 YKITVIPGDGIGKEVMEAALYVLDALD----LNFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAVTSTPGQKS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 139 ekhlrpemGLLNIRRDLNVFANLRPatvlpqlVDASTLKKEVAQGVDMMIVRELTGGIYFGEprgitINENGEEVGFNTE 218
Cdd:NF040626   78 --------PIITLRKELDLYANLRP-------IKSYEGINCLFKDLDFLIVRENTEGLYSGL-----EEEYTEEKAIAER 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 219 IYAAHEIDRIARVAFETARKR-RGKLCSVDKANVLDASI-LWRKRVTALASEYPDVELSHMYVDNAAMQLVRDPKQFDTI 296
Cdd:NF040626  138 VITRKASERICKFAFEYAIKLgRKKVTAVHKANVLKKTDgIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDVI 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 297 VTNNIFGDILSDEASMITGSIGMLPSASLGESGpGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAAKMIE 376
Cdd:NF040626  218 VTTNLFGDILSDEAAGLVGGLGLAPSANIGDKN-GLFEPVHGSAPDIAGKNIANPIAMILSASMMLDY-LGETYEANKLE 295

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 2065885258 377 DAVVDALNKG-FRTGDIYSPGNKLvgckEMGEEVLKSVDSK 416
Cdd:NF040626  296 NALEKVLREGkVVTPDLGGNAKTM----EMANEIKKKIEEL 332
LEU3_arch TIGR02088
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal ...
 61-410 1.10e-82

isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal decarboxylating dehydrogenases which include the leucine biosynthesis enzyme 3-isopropylmalate dehydrogenase (LeuB, LEU3) and the methanogenic cofactor CoB biosynthesis enzyme isohomocitrate dehydrogenase (AksF). Both of these have been characterized in Methanococcus janaschii. Non-methanogenic archaea have only one hit to this model and presumably this is LeuB, although phylogenetic trees cannot establish which gene is which in the methanogens. The AksF gene is capable of acting on isohomocitrate, iso(homo)2-citrate and iso(homo)3-citrate in the successive elongation cycles of coenzyme B (7-mercaptoheptanoyl-threonine phosphate). This family is closely related to both the LeuB genes found in TIGR00169 and the mitochondrial eukaryotic isocitrate dehydratases found in TIGR00175. All of these are included within the broader subfamily model, pfam00180.


Pssm-ID: 273962  Cd Length: 322  Bit Score: 256.61  E-value: 1.10e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  61 ITLLPGDGIGPEVISVAKNVLQKAGflqgLEFDFQEMPFGGAALDLVGVPLPEETSTAAKQSDAILLGAIGGYKwDKNEK 140
Cdd:TIGR02088   1 VAVIPGDGIGPEVIEAAIRILNKLG----LEIEFIEFEAGDEALKKYGSALPEDTLEEIRKADAILFGAVTTPA-NPGYK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 141 HLrpemgLLNIRRDLNVFANLRPATVLPQLVDASTLkkevaqGVDMMIVRELTGGIYfgeprgitineNGEEVGFNTEIY 220
Cdd:TIGR02088  76 SV-----IVTLRKELDLYANVRPAKSLPGIPDLYPN------GKDIVIVRENTEGLY-----------AGFEFGFSDRAI 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 221 AAHEI-----DRIARVAFETARKRRGKLCSVDKANVLDAS-ILWRKRVTALASEYpDVELSHMYVDNAAMQLVRDPKQFD 294
Cdd:TIGR02088 134 AIRVItregsERIARFAFNLAKERNRKVTCVHKANVLKGTdGLFREVCREIAKRY-GVEYRDMYVDSAAMNLVKDPWRFD 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 295 TIVTNNIFGDILSDEASMITGSIGMLPSASLGESgPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAAKM 374
Cdd:TIGR02088 213 VIVTTNMFGDILSDLASALAGSLGLAPSANIGDR-KALFEPVHGSAPDIAGKGIANPTAAILSVAMMLDY-LGELEKGKL 290

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 2065885258 375 IEDAVVDALNKGFRTGDIyspGNKLVgCKEMGEEVL 410
Cdd:TIGR02088 291 VWEAVEYYIIEGKKTPDL---GGTAK-TKEVGDEIA 322
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 57-413 2.01e-73

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 233.46  E-value: 2.01e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  57 KRYNITLLPGDGIGPEVISVAKNVLQKAGFLQG-LEFDFQEMPFGGAALDLVGVPLPEETSTAAKQSDAILLGAIGGYKW 135
Cdd:PRK08194    2 KQFKIAVIPGDGVGKEVVPAAVRVLKAVAEVHGgLKFEFTEFPWSCEYYLEHGEMMPEDGLEQLKQFDAIFLGAVGNPKL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 136 DKNEKHLrpeMGLL-NIRRDLNVFANLRPATVLPQLVdaSTLKKevAQGVDMMIVRELTGGIYfgEPRGITINENGEEVG 214
Cdd:PRK08194   82 VPDHISL---WGLLiKIRREFEQVINIRPAKQLRGIK--SPLAN--PKDFDLLVVRENSEGEY--SEVGGRIHRGEDEIA 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 215 FNTEIYAAHEIDRIARVAFETARKRRGKLCSVDKANVLDASI-LWRKRVTALASEYPDVELSHMYVDNAAMQLVRDPKQF 293
Cdd:PRK08194  153 IQNAVFTRKGTERAMRYAFELAAKRRKHVTSATKSNGIVHSMpFWDEVFQEVGKDYPEIETDSQHIDALAAFFVTRPEEF 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 294 DTIVTNNIFGDILSDEASMITGSIGMLPSASLGESG--PGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKA 371
Cdd:PRK08194  233 DVIVASNLFGDILTDIGAAIMGSIGIAPAANINVNGkyPSMFEPVHGSAPDIAGKGIANPIGQIWTAKLMLDH-FGEEEL 311

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 2065885258 372 AKMIEDAVVDALNKGFRTGDIyspGNKlVGCKEMGEEVLKSV 413
Cdd:PRK08194  312 GSHLLDVIEDVTEDGIKTPDI---GGR-ATTDEVTDEIISRL 349
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 61-389 1.33e-72

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 230.76  E-value: 1.33e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  61 ITLLPGDGIGPEVISVAKNVLQKAGflQGLEFDFQEMpfGGAALDLVGVPLPEETSTAAKQSDAILLGAI----GGYKWD 136
Cdd:PRK08997    5 ITVIPGDGIGPSIIDATLKILDKLG--CDFEYEFADA--GLTALEKHGELLPQRTLDLIEKNKIALKGPLttpvGEGFTS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 137 KNekhlrpemglLNIRRDLNVFANLRPATVLPQlvdastlKKEVAQGVDMMIVRELTGGIYFGEprGITINENGEEvGFN 216
Cdd:PRK08997   81 IN----------VTLRKKFDLYANVRPVLSFPG-------TKARYDNIDIITVRENTEGMYSGE--GQTVSEDGET-AEA 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 217 TEIYAAHEIDRIARVAFETARKR-RGKLCSVDKANVLDA-SILWRKRVTALASEYPDVELSHMYVDNAAMQLVRDPKQFD 294
Cdd:PRK08997  141 TSIITRKGAERIVRFAYELARKEgRKKVTAVHKANIMKStSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFD 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 295 TIVTNNIFGDILSDEASMITGSIGMLPSASLGESGpGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAAKM 374
Cdd:PRK08997  221 VIVTTNLFGDILSDLCAGLVGGLGMAPGANIGRDA-AIFEAVHGSAPDIAGKNLANPTSVILAAIQMLEY-LGMPDKAER 298

                         330
                  ....*....|....*
gi 2065885258 375 IEDAVVDALNKGFRT 389
Cdd:PRK08997  299 IRKAIVAVIEAGDRT 313
AksF_Meth NF040619
homoisocitrate dehydrogenase;
59-409 2.59e-68

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 219.63  E-value: 2.59e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  59 YNITLLPGDGIGPEVISVAKNVLQKAGflqglEFDFQEMPFGGAALDLVGVPLPEETSTAAKQSDAILLGAIGGYKWD-- 136
Cdd:NF040619    2 PKICVIEGDGIGKEVIPETVRVLKELG-----DFEFIKGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPKPTel 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 137 KNEKHLRPemgLLNIRRDLNVFANLRPATVLPQLVDAstlkkevaQGVDMMIVRELTGGIYFGEPRgitINENGEeVGFN 216
Cdd:NF040619   77 KNKNYKSP---ILTLRKELDLYANVRPINNFGDGQDV--------KNIDFVIIRENTEGLYVGREY---YDEENE-IAIA 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 217 TEIYAAHEIDRIARVAFETARK-RRGKLCSVDKANVLDASI-LWRKRVTALASEY--PDVELSHMYVDNAAMQLVRDPKQ 292
Cdd:NF040619  142 ERIISKKGSERIIKFAFEYAKKnNRKKVSCIHKANVLRVTDgLFLEIFNEIKKKYknFNIEADDYLVDATAMYLIKNPEM 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 293 FDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESgPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAA 372
Cdd:NF040619  222 FDVIVTTNLFGDILSDEASGLIGGLGLAPSANIGDK-KGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDY-LGMKEKG 299

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 2065885258 373 KMIEDAVVDALNKGFRTGDIyspGNKLvGCKEMGEEV 409
Cdd:NF040619  300 DLIREAVKKCLENGKVTPDL---GGNL-KTKEVTDKI 332
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
61-411 1.02e-59

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 201.66  E-value: 1.02e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  61 ITLLPGDGIGPEVISVAKNVLQKAGflQGLEFDFQEMpfgGAALDLVGVP--LPEETSTAAKQSDAILLGAI-----GGY 133
Cdd:PRK09222    7 ITVAYGDGIGPEIMEAVLKILEAAG--APLEIETIEI---GEKVYKKGWTsgISPSAWESIRRTKVLLKAPIttpqgGGY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 134 KwdknekhlrpemgLLN--IRRDLNVFANLRPATVLPQLVDAStlkkevAQGVDMMIVRE----LTGGIyfgEPRgITin 207
Cdd:PRK09222   82 K-------------SLNvtLRKTLGLYANVRPCVSYHPFVETK------HPNLDVVIIREneedLYAGI---EHR-QT-- 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 208 engeevgfnTEIYAAHEI------DRIARVAFETARKR-RGKLCSVDKANVLDASILWRKRV-TALASEYPDVELSHMYV 279
Cdd:PRK09222  137 ---------PDVYQCLKLisrpgsEKIIRYAFEYARANgRKKVTCLTKDNIMKLTDGLFHKVfDEIAKEYPDIEAEHYIV 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 280 DNAAMQLVRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGpGLFEPIHGSAPDIAGQDKANPLATILSAA 359
Cdd:PRK09222  208 DIGAARLATNPENFDVIVTPNLYGDILSDIAAEISGSVGLAGSANIGEEY-AMFEAVHGSAPDIAGKNIANPSGLLNAAV 286

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2065885258 360 MLLKYgLGEEKAAKMIEDAVVDALNKGFRTGDIYSPG--NKLVGCKEMGEEVLK 411
Cdd:PRK09222  287 MMLVH-IGQFDIAELIENAWLKTLEDGIHTADIYNEGvsKKKVGTKEFAEAVIE 339
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 34-392 7.62e-47

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 164.67  E-value: 7.62e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  34 SSLTDHKFRAPYRIRCAAASPVKKryniTLLPGDGIGPEVISVAKNVLQKAGflqglefdfqempfggaaldlvgVPLPE 113
Cdd:PLN00118   21 SSSSSGAFSSSARAFSSSSTPITA----TLFPGDGIGPEIAESVKQVFTAAG-----------------------VPIEW 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 114 ETSTAAKQSDAILLGAIggyKWDKNEKHLRPEMGL----------------LNIRRDLNVFANLRPATVLPQLvdastlk 177
Cdd:PLN00118   74 EEHYVGTTVDPRTGSFL---TWESLESVRRNKVGLkgpmatpigkghrslnLTLRKELGLYANVRPCYSLPGY------- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 178 KEVAQGVDMMIVRELTGGIYFGEPRGITinengEEVGFNTEIYAAHEIDRIARVAFETARKR-RGKLCSVDKANVLD-AS 255
Cdd:PLN00118  144 KTRYDDVDLVTIRENTEGEYSGLEHQVV-----RGVVESLKIITRQASLRVAEYAFHYAKTHgRKRVSAIHKANIMKkTD 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 256 ILWRKRVTALASEYPDVELSHMYVDNAAMQLVRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEP 335
Cdd:PLN00118  219 GLFLKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLIGGLGLTPSCNIGENGLALAEA 298

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2065885258 336 IHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAAKMIEDAVVDALNKG-FRTGDI 392
Cdd:PLN00118  299 VHGSAPDIAGKNLANPTALLLSAVMMLRH-LKLNEQAEQIHNAILNTIAEGkYRTADL 355
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 66-415 2.45e-41

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 151.03  E-value: 2.45e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  66 GDGIGPEVISVAKNVLQKA---GFLQGLEFDFQEMPFGGAALDLVGVPLPEETSTAAKQSDAILLGAI-----GGYKwdk 137
Cdd:COG0538    26 GDGIGPEITRAIWKVIDAAvekAYGGKRDIEWKEVDAGEKARDETGDWLPDETAEAIKEYGVGIKGPLttpvgGGWR--- 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 138 nekhlrpemgLLN--IRRDLNVFANLRPATV---LPQLVdastlkKEvAQGVDMMIVRELTGGIYfgepRGITINENGEE 212
Cdd:COG0538   103 ----------SLNvtIRQILDLYVCRRPVRYfkgVPSPV------KH-PEKVDIVIFRENTEDIY----AGIEWKAGSPE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 213 V---------GFNTEIYAAHE-------------IDRIARVAFETA--RKRRgKLCSVDKANVL---------------- 252
Cdd:COG0538   162 AlkliffledEMGVTVIRFPEdsgigikpvsdegTERLVRAAIQYAldNKRK-SVTLVHKGNIMkftegafkdwgyevae 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 253 ----DASI---LWRKRVTALASEypDVELSHMYVDNAAMQLVRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASL 325
Cdd:COG0538   241 eefgDKFItegPWEKYKGPKPAG--KIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANI 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 326 GESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAAKMIEDAVVDALNKGFRTGDI--YSPGNKLVGCK 403
Cdd:COG0538   319 GDDGGAEFEATHGTAPKYAGKDSTNPGSLILSGTMMLRH-RGWLEAADLIEKAVEKTIESGKVTYDLarLMEGATELSTS 397

                         410
                  ....*....|..
gi 2065885258 404 EMGEEVLKSVDS 415
Cdd:COG0538   398 EFGDAIIENLDK 409
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
61-415 5.68e-37

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 139.20  E-value: 5.68e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  61 ITLLPGDGIGPEVISVAKNVLQKA---GFLQGLEFDFQEMPFGGAALDLVGVPLPEETSTAAKQSDAILLGAI-----GG 132
Cdd:PRK06451   26 ILYVEGDGIGPEITHAAMKVINKAvekAYGSDREIKWVEVLAGDKAEKLTGNRFPKESEELIEKYRVLLKGPLetpigKG 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 133 YKWDKnekhlrpemglLNIRRDLNVFANLRPATVLPQLvdASTLKKevAQGVDMMIVRELTGGIYfgepRGITINENGEE 212
Cdd:PRK06451  106 WKSIN-----------VAIRLMLDLYANIRPVKYIPGI--ESPLKN--PEKIDLIIFRENTDDLY----RGIEYPYDSEE 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 213 V-------------------GFNTEIYAAHEIDRIARVAFETA-RKRRGKLCSVDKANVLDAS----------------- 255
Cdd:PRK06451  167 AkkirdflrkelgveveddtGIGIKLISKFKTQRIARMAIKYAiDHKRKKVTIMHKGNVMKYTegafrewayevalkefr 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 256 --ILWRKRVTALASEYPD---VELSHMYVDNAAMQLVRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGp 330
Cdd:PRK06451  247 dyVVTEEEVTKNYNGVPPsgkVIINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTG- 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 331 GLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAAKMIEDAVVDALNKGFRTGDIYS-PGNKLVGCKEMGEEV 409
Cdd:PRK06451  326 GMFEAIHGTAPKYAGKNVANPTGIIKGGELMLRF-MGWDKAADLIDKAIMESIKQKKVTQDLARfMGVRALSTTEYTDEL 404


                  ....*.
gi 2065885258 410 LKSVDS 415
Cdd:PRK06451  405 ISIIDM 410
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 61-392 1.90e-31

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 123.05  E-value: 1.90e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  61 ITLLPGDGIGPEVISVAKNVLQKagflQGLEFDFQEMPFGGAALDLvgvplPEETSTAAKQSDAILLGA----IGGYKWD 136
Cdd:PLN00123   33 VTLIPGDGIGPLVTGAVEQVMEA----MHAPVYFERYEVHGDMKKV-----PEEVLESIRRNKVCLKGGlatpVGGGVSS 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 137 KNekhlrpemglLNIRRDLNVFANLRPATVLPQLvdastlkKEVAQGVDMMIVRELTGGIYFGEPrgitiNENGEEVGFN 216
Cdd:PLN00123  104 LN----------VQLRKELDLFASLVNCFNLPGL-------PTRHENVDIVVIRENTEGEYSGLE-----HEVVPGVVES 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 217 TEIYAAHEIDRIARVAFETAR-KRRGKLCSVDKANVLD-ASILWRKRVTALASEYPDVELSHMYVDNAAMQLVRDPKQFD 294
Cdd:PLN00123  162 LKVITKFCSERIAKYAFEYAYlNNRKKVTAVHKANIMKlADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFD 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 295 TIVTNNIFGDILSDEASMITGSIGMLPSASLGeSGPGLFEPIHGSA----PDIAGQDKANPLATILSAAMLLKYgLGEEK 370
Cdd:PLN00123  242 VMVTPNLYGNLVANTAAGIAGGTGVMPGGNVG-ADHAVFEQGASAGnvgnEKLVEQKKANPVALLLSSAMMLRH-LQFPS 319

                         330       340
                  ....*....|....*....|...
gi 2065885258 371 AAKMIEDAVVDALNKG-FRTGDI 392
Cdd:PLN00123  320 FADRLETAVKRVIAEGkYRTKDL 342
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 61-411 8.13e-20

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 90.51  E-value: 8.13e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258  61 ITLLPGDGIGPEVISVAKNVLQKA---GFLQGLEFDFQEMPFGGAALDLVG--VPLPEETSTAAKQSD-AI---LLGAIG 131
Cdd:PRK07006   22 IPFIEGDGIGPDITPAMLKVVDAAvekAYKGERKISWMEIYAGEKATKVYGedVWLPEETLDLIREYRvAIkgpLTTPVG 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 132 GykwdknekhlrpemGL--LNI--RRDLNVFANLRPA---TVLPqlvdaSTLKKevAQGVDMMIVRELTGGIYfgepRGI 204
Cdd:PRK07006  102 G--------------GIrsLNValRQELDLYVCLRPVryfKGVP-----SPVKR--PEDTDMVIFRENSEDIY----AGI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 205 TINENGEEV----GFNTEIYAAHEI------------------DRIARVAFETA-RKRRGKLCSVDKANVLD-ASILWRK 260
Cdd:PRK07006  157 EWKAGSAEAkkviKFLQEEMGVKKIrfpetsgigikpvseegtERLVRAAIEYAiDNDRKSVTLVHKGNIMKfTEGAFKD 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 261 RVTALA-SEYPDVELS---HMYVDNAAMQ---LVRD-------------PKQFDTIVTNNIFGDILSDEASMITGSIGML 320
Cdd:PRK07006  237 WGYQLAeEEFGDELIDggpWDKIKNPETGkeiIVKDsiadaflqqillrPAEYDVIATMNLNGDYISDALAAQVGGIGIA 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 321 PSASLGeSGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAAKMIEDAVVDALNKGFRTGDIYS--PGNK 398
Cdd:PRK07006  317 PGANIN-DGHAIFEATHGTAPKYAGLDKVNPGSVILSAEMMLRH-MGWTEAADLIIKSMEKTIASKTVTYDFARlmEGAT 394

                         410
                  ....*....|...
gi 2065885258 399 LVGCKEMGEEVLK 411
Cdd:PRK07006  395 EVKCSEFGDALIK 407
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
280-411 1.70e-16

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 81.30  E-value: 1.70e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 280 DNAAMQLVRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGpGLFEPIHGSAPDIAGQDKANPLATILSAA 359
Cdd:PRK07362  340 DSIFQQIQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNA-AIFEATHGTAPKHAGLDRINPGSVILSGV 418

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2065885258 360 MLLKYgLGEEKAAKMIEDAVVDALNKGFRTGDI---YSPGNKLVGCKEMGEEVLK 411
Cdd:PRK07362  419 MMLEY-LGWQEAADLITKGLSAAIANKQVTYDLarlMEPPVDPLSCSEFAEAIIS 472
PLN00096 PLN00096
isocitrate dehydrogenase (NADP+); Provisional
 270-360 1.77e-03

isocitrate dehydrogenase (NADP+); Provisional


Pssm-ID: 177715  Cd Length: 393  Bit Score: 40.40  E-value: 1.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065885258 270 PDVELSHMYVDNAAMQLVRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGL----FEPIHGSAPD--- 342
Cdd:PLN00096  235 SGDELVHLLSDAATMKLVVWTDGGFGMAAHNYDGDVLTDELAQVHKSPGFITSNLVGVDENGTlikeFEASHGTVTDmde 314

                          90       100
                  ....*....|....*....|...
gi 2065885258 343 --IAGQDKA-NPLATI--LSAAM 360
Cdd:PLN00096  315 arLRGEETSlNPLGMVegLIGAM 337
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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