|
Name |
Accession |
Description |
Interval |
E-value |
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
30-786 |
3.05e-126 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 405.34 E-value: 3.05e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 30 EQQDDLEGADEALIKEEQEARL-ENERNEEKRRQAMLKRKKKKKAETKSEReAKAReLDDLLAKSAAFSDILT------- 101
Cdd:PLN03142 44 EDDEEAESPAKAEISKREKARLkELKKQKKQEIQKILEQQNAAIDADMNNK-GKGR-LKYLLQQTEIFAHFAKgdqsasa 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 102 KKTQVLGRVGSSL-------------DGKTLGEHSLEMAQQPKCmINGTMRDYQLEGLTWMYEICSQGMSGILADEMGLG 168
Cdd:PLN03142 122 KKAKGRGRHASKLteeeedeeylkeeEDGLGGSGGTRLLVQPSC-IKGKMRDYQLAGLNWLIRLYENGINGILADEMGLG 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 169 KTVQTIALIALLREQENYLGPHLIVAPLSTLSNWEDEFTKWTPSIPVIMYHGNKDDREKIfRTKMLKhlkAGrpttKFPV 248
Cdd:PLN03142 201 KTLQTISLLGYLHEYRGITGPHMVVAPKSTLGNWMNEIRRFCPVLRAVKFHGNPEERAHQ-REELLV---AG----KFDV 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 249 VCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKLFQQLRQFSSATRLLITGTPLQNNLKELWSLLHFLLPNIFTDW 328
Cdd:PLN03142 273 CVTSFEMAIKEKTALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSA 352
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 329 EAFESWFDFSDLEDEqgteefiadqkkQELVKKIHLILQPMLLRRIKQDVAAYLPKKREYVLFAPMTKEQTDLYNVLTNK 408
Cdd:PLN03142 353 ETFDEWFQISGENDQ------------QEVVQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYYKALLQK 420
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 409 KVDtrqyledkvhekiygtksteastkssrsssvaapntmtlpvresprkqqvepeepAANvfsvmmakrgrgrprknpk 488
Cdd:PLN03142 421 DLD-------------------------------------------------------VVN------------------- 426
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 489 leeapvtpkSGGKRkgapaslepepksakstrqstpvstrgrprktrtykdagsdeekmsddefeaklakemvsddedls 568
Cdd:PLN03142 427 ---------AGGER------------------------------------------------------------------ 431
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 569 gqvpltleeraqaeafelakkqigqKKLGNPLAQLRLVCNSPHNFYN-----PWIAstdlpvDDSIVTASGKMLLLDRLL 643
Cdd:PLN03142 432 -------------------------KRLLNIAMQLRKCCNHPYLFQGaepgpPYTT------GEHLVENSGKMVLLDKLL 480
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 644 PRLFQDDHKVLIFSQFTTQLDILEDYCReLRGWKVCRIDGSVAQESRRTQIADFNSDPEYK-IFLLSTRAGGQGINLASA 722
Cdd:PLN03142 481 PKLKERDSRVLIFSQMTRLLDILEDYLM-YRGYQYCRIDGNTGGEDRDASIDAFNKPGSEKfVFLLSTRAGGLGINLATA 559
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2033488177 723 DTVILFDSDFNPQQDLQAQDRCHRIGQTRPVVVFRLATKDTVEENLLNSADAKRRLEKLVIKKG 786
Cdd:PLN03142 560 DIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALDALVIQQG 623
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
135-375 |
3.04e-115 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 350.53 E-value: 3.04e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 135 NGTMRDYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIALLREQENYlGPHLIVAPLSTLSNWEDEFTKWTPSIP 214
Cdd:cd18009 1 GGVMRPYQLEGMEWLRMLWENGINGILADEMGLGKTIQTIALLAHLRERGVW-GPFLVIAPLSTLPNWVNEFARFTPSVP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 215 VIMYHGNKDDREKIfRTKMLKHLKAGRpttKFPVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKLFQQLRQFS 294
Cdd:cd18009 80 VLLYHGTKEERERL-RKKIMKREGTLQ---DFPVVVTSYEIAMRDRKALQHYAWKYLIVDEGHRLKNLNCRLIQELKTFN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 295 SATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFESWFDFSDLEDEQGTEEFIADQKKQELVKKIHLILQPMLLRRI 374
Cdd:cd18009 156 SDNRLLLTGTPLQNNLSELWSLLNFLLPDVFDDLSSFESWFDFSSLSDNAADISNLSEEREQNIVHMLHAILKPFLLRRL 235
|
.
gi 2033488177 375 K 375
Cdd:cd18009 236 K 236
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
33-783 |
8.02e-113 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 360.31 E-value: 8.02e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 33 DDLEGADEALIKEEQEARLENERNEEKRRQAMLKRKKKKKAETKSEREAKARELDDLLAKSAAFSDILTKKTQVLGRVGS 112
Cdd:COG0553 138 LLVLLAALLLLLLLLLLLALLLGRLLLLALLLLALEALLLLGLLLALALLALLELALLAAEAELLLLLELLLELELLAEA 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 113 SLDGKTLGEHSLEMAQQPKCMiNGTMRDYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIALLREQENyLGPHLI 192
Cdd:COG0553 218 AVDAFRLRRLREALESLPAGL-KATLRPYQLEGAAWLLFLRRLGLGGLLADDMGLGKTIQALALLLELKERGL-ARPVLI 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 193 VAPLSTLSNWEDEFTKWTPSIPVIMYHGNKDdrekifRTKMLKHLKagrpttKFPVVCTSYEMVLRDQHNLSKINWEFII 272
Cdd:COG0553 296 VAPTSLVGNWQRELAKFAPGLRVLVLDGTRE------RAKGANPFE------DADLVITSYGLLRRDIELLAAVDWDLVI 363
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 273 IDEGHRMKNADAKLFQQLRQFSSATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFESWFDFSDLEDeqgteefiaD 352
Cdd:COG0553 364 LDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIEKG---------D 434
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 353 QKKQELVKKihlILQPMLLRRIKQDVAAYLPKKREYVLFAPMTKEQTDLYnvltnkkvdtrqyledkvhekiygtkstea 432
Cdd:COG0553 435 EEALERLRR---LLRPFLLRRTKEDVLKDLPEKTEETLYVELTPEQRALY------------------------------ 481
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 433 stkssrsssvaapntmtlpvresprkqqvepeepaanvfsvmmakrgrgrprknpkleeapvtpksggkrkgapaslepe 512
Cdd:COG0553 --------------------------------------------------------------------------------
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 513 pksakstrqstpvstrgrprktrtykdagsdeekmsdDEFEAKLAKEMVSDDEDLSGQVPLTLeeraqaeafelakkqig 592
Cdd:COG0553 482 -------------------------------------EAVLEYLRRELEGAEGIRRRGLILAA----------------- 507
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 593 qkklgnpLAQLRLVCNSPHNFynpwiastdLPVDDSIVTASGKMLLLDRLLPRLFQDDHKVLIFSQFTTQLDILEDYCRE 672
Cdd:COG0553 508 -------LTRLRQICSHPALL---------LEEGAELSGRSAKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEE 571
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 673 lRGWKVCRIDGSVAQESRRTQIADFNSDPEYKIFLLSTRAGGQGINLASADTVILFDSDFNPQQDLQAQDRCHRIGQTRP 752
Cdd:COG0553 572 -RGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRD 650
|
730 740 750
....*....|....*....|....*....|.
gi 2033488177 753 VVVFRLATKDTVEENLLNSADAKRRLEKLVI 783
Cdd:COG0553 651 VQVYKLVAEGTIEEKILELLEEKRALAESVL 681
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
135-375 |
1.09e-104 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 322.73 E-value: 1.09e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 135 NGTMRDYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIALLREQENYLGPHLIVAPLSTLSNWEDEFTKWTPSIP 214
Cdd:cd17997 1 GGTMRDYQIRGLNWLISLFENGINGILADEMGLGKTLQTISLLGYLKHYKNINGPHLIIVPKSTLDNWMREFKRWCPSLR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 215 VIMYHGNKDDREKIFRTKMLkhlkagrpTTKFPVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKLFQQLRQFS 294
Cdd:cd17997 81 VVVLIGDKEERADIIRDVLL--------PGKFDVCITSYEMVIKEKTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFN 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 295 SATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFESWFDFSDLEDEQgteefiadqkkQELVKKIHLILQPMLLRRI 374
Cdd:cd17997 153 SRNRLLLTGTPLQNNLHELWALLNFLLPDVFTSSEDFDEWFNVNNCDDDN-----------QEVVQRLHKVLRPFLLRRI 221
|
.
gi 2033488177 375 K 375
Cdd:cd17997 222 K 222
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
141-403 |
7.14e-97 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 304.61 E-value: 7.14e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 141 YQLEGLTWMYEICSQ-GMSGILADEMGLGKTVQTIALI-ALLREQENYLGPHLIVAPLSTLSNWEDEFTKWT--PSIPVI 216
Cdd:pfam00176 1 YQIEGVNWMLSLENNlGRGGILADEMGLGKTLQTISLLlYLKHVDKNWGGPTLIVVPLSLLHNWMNEFERWVspPALRVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 217 MYHGNKDDREKIFRTKMLKHlkagrpttKFPVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKLFQQLRQFSSA 296
Cdd:pfam00176 81 VLHGNKRPQERWKNDPNFLA--------DFDVVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 297 TRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFESWFDFSdledeqgteefIADQKKQELVKKIHLILQPMLLRRIKQ 376
Cdd:pfam00176 153 NRWILTGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRP-----------IERGGGKKGVSRLHKLLKPFLLRRTKK 221
|
250 260
....*....|....*....|....*..
gi 2033488177 377 DVAAYLPKKREYVLFAPMTKEQTDLYN 403
Cdd:pfam00176 222 DVEKSLPPKVEYILFCRLSKLQRKLYQ 248
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
135-375 |
3.95e-93 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 292.74 E-value: 3.95e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 135 NGTMRDYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIALLREQENYLGPHLIVAPLSTLSNWEDEFTKWTPSIP 214
Cdd:cd17996 1 GGTLKEYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLITYLMEKKKNNGPYLVIVPLSTLSNWVSEFEKWAPSVS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 215 VIMYHGNKDDREKIFRTKMlkhlkagrpTTKFPVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKLFQQL-RQF 293
Cdd:cd17996 81 KIVYKGTPDVRKKLQSQIR---------AGKFNVLLTTYEYIIKDKPLLSKIKWKYMIIDEGHRMKNAQSKLTQTLnTYY 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 294 SSATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFESWFDfSDLEDEQGTEEFIADQKKQELV-KKIHLILQPMLLR 372
Cdd:cd17996 152 HARYRLLLTGTPLQNNLPELWALLNFLLPKIFKSCKTFEQWFN-TPFANTGEQVKIELNEEETLLIiRRLHKVLRPFLLR 230
|
...
gi 2033488177 373 RIK 375
Cdd:cd17996 231 RLK 233
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
138-322 |
5.21e-85 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 269.05 E-value: 5.21e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 138 MRDYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIALLREQENYLGPHLIVAPLSTLSNWEDEFTKWTPSIPVIM 217
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGPGGILADEMGLGKTLQAIAFLAYLLKEGKERGPVLVVCPLSVLENWEREFEKWTPDLRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 218 YHGNKDDREKIFRTKMLKhlkagrpttKFPVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKLFQQLRQFSSAT 297
Cdd:cd17919 81 YHGSQRERAQIRAKEKLD---------KFDVVLTTYETLRRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKR 151
|
170 180
....*....|....*....|....*
gi 2033488177 298 RLLITGTPLQNNLKELWSLLHFLLP 322
Cdd:cd17919 152 RLLLTGTPLQNNLEELWALLDFLDP 176
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
137-373 |
8.43e-83 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 264.99 E-value: 8.43e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 137 TMRDYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIALLREQENYLGPHLIVAPLSTLSNWEDEFTKWTPSIPVI 216
Cdd:cd17993 1 ELRDYQLTGLNWLAHSWCKGNNGILADEMGLGKTVQTISFLSYLFHSQQQYGPFLVVVPLSTMPAWQREFAKWAPDMNVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 217 MYHGNKDDREKIFRTKMLKhlkAGRPTTKFPVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKLFQQLRQFSSA 296
Cdd:cd17993 81 VYLGDIKSRDTIREYEFYF---SQTKKLKFNVLLTTYEIILKDKAFLGSIKWQYLAVDEAHRLKNDESLLYEALKEFKTN 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2033488177 297 TRLLITGTPLQNNLKELWSLLHFLLPniftdwEAFESWFDFSDLEDEqgteefiaDQKKQelVKKIHLILQPMLLRR 373
Cdd:cd17993 158 NRLLITGTPLQNSLKELWALLHFLMP------GKFDIWEEFEEEHDE--------EQEKG--IADLHKELEPFILRR 218
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
138-373 |
1.14e-81 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 261.80 E-value: 1.14e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 138 MRDYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIALLREQENYLGPHLIVAPLSTLSNWEDEFTKWTPsIPVIM 217
Cdd:cd17995 1 LRDYQLEGVNWLLFNWYNRRNCILADEMGLGKTIQSIAFLEHLYQVEGIRGPFLVIAPLSTIPNWQREFETWTD-MNVVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 218 YHGNKDDREKIFRTKMLKHLKAGRP---TTKFPVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKLFQQLRQFS 294
Cdd:cd17995 80 YHGSGESRQIIQQYEMYFKDAQGRKkkgVYKFDVLITTYEMVIADAEELRKIPWRVVVVDEAHRLKNRNSKLLQGLKKLT 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2033488177 295 SATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFESwfDFSDLedeqgteefiadqKKQELVKKIHLILQPMLLRR 373
Cdd:cd17995 160 LEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLE--EFGDL-------------KTAEQVEKLQALLKPYMLRR 223
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
138-373 |
2.49e-78 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 253.04 E-value: 2.49e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 138 MRDYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIALLREQENYLGPHLIVAPLSTLSNWEDEFTKWTPSIPVIM 217
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAHLACEKGNWGPHLIVVPTSVMLNWEMEFKRWCPGFKILT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 218 YHGNKDDREkifrtkmLKHLKAGRPTTkFPVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKLFQQLRQFSSAT 297
Cdd:cd18003 81 YYGSAKERK-------LKRQGWMKPNS-FHVCITSYQLVVQDHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQR 152
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2033488177 298 RLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFESWF-DFSDLEDEQGTEEfiadqkKQELVKKIHLILQPMLLRR 373
Cdd:cd18003 153 RLLLTGTPLQNSLMELWSLMHFLMPHIFQSHQEFKEWFsNPLTAMSEGSQEE------NEELVRRLHKVLRPFLLRR 223
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
128-375 |
3.66e-72 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 236.84 E-value: 3.66e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 128 QQPKCMINGTMRDYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIALLREQENYLGPHLIVAPLSTLSNWEDEFT 207
Cdd:cd18065 6 ESPSYVKGGTLRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNEFK 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 208 KWTPSIPVIMYHGNKDDREKIFRTKMLKhlkagrptTKFPVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKLF 287
Cdd:cd18065 86 RWVPSLRAVCLIGDKDARAAFIRDVMMP--------GEWDVCVTSYEMVIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 288 QQLRQFSSATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFESWFDfsdledeqgTEEFIADQKkqeLVKKIHLILQ 367
Cdd:cd18065 158 EIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWFD---------TKNCLGDQK---LVERLHAVLK 225
|
....*...
gi 2033488177 368 PMLLRRIK 375
Cdd:cd18065 226 PFLLRRIK 233
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
136-386 |
3.35e-71 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 234.95 E-value: 3.35e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 136 GTMRDYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIALLREQENYLGPHLIVAPLSTLSNWEDEFTKWTPSIPV 215
Cdd:cd18064 14 GKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPHMVLVPKSTLHNWMAEFKRWVPTLRA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 216 IMYHGNKDDREKIFRTKMLKhlkagrptTKFPVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKLFQQLRQFSS 295
Cdd:cd18064 94 VCLIGDKDQRAAFVRDVLLP--------GEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 296 ATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFESWFDfsdledeqgTEEFIADQKkqeLVKKIHLILQPMLLRRIK 375
Cdd:cd18064 166 TNRLLLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDSWFD---------TNNCLGDQK---LVERLHMVLRPFLLRRIK 233
|
250
....*....|.
gi 2033488177 376 QDVAAYLPKKR 386
Cdd:cd18064 234 ADVEKSLPPKK 244
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
138-373 |
2.98e-70 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 231.82 E-value: 2.98e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 138 MRDYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIALLREQENYLGPHLIVAPLSTLSNWEDEFTKWTPSIPVIM 217
Cdd:cd18054 21 LRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLLVVPLSTLTSWQREFEIWAPEINVVV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 218 YHGNKDDREKIfRTKMLKHLKAGRptTKFPVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKLFQQLRQFSSAT 297
Cdd:cd18054 101 YIGDLMSRNTI-REYEWIHSQTKR--LKFNALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLLYKTLIDFKSNH 177
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2033488177 298 RLLITGTPLQNNLKELWSLLHFLLPniftdwEAFESWFDFsdlEDEQGteefiadQKKQELVKKIHLILQPMLLRR 373
Cdd:cd18054 178 RLLITGTPLQNSLKELWSLLHFIMP------EKFEFWEDF---EEDHG-------KGRENGYQSLHKVLEPFLLRR 237
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
123-375 |
9.40e-70 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 231.11 E-value: 9.40e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 123 SLEMAQQPKCMINGTMRDYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIALLREQENYLGPHLIVAPLSTLSNW 202
Cdd:cd18063 9 TERVEKQSSLLINGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 203 EDEFTKWTPSIPVIMYHGNkddreKIFRTKMLKHLKAGrpttKFPVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNA 282
Cdd:cd18063 89 TYEFDKWAPSVVKISYKGT-----PAMRRSLVPQLRSG----KFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNH 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 283 DAKLFQQLR-QFSSATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFESWFD--FSdledEQGTEEFIADQKKQELV 359
Cdd:cd18063 160 HCKLTQVLNtHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNapFA----MTGERVDLNEEETILII 235
|
250
....*....|....*.
gi 2033488177 360 KKIHLILQPMLLRRIK 375
Cdd:cd18063 236 RRLHKVLRPFLLRRLK 251
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
138-373 |
8.81e-68 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 225.08 E-value: 8.81e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 138 MRDYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIALLREQENYLGPHLIVAPLSTLSNWEDEFTKWTPSIPVIM 217
Cdd:cd18002 1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLAHLAEEHNIWGPFLVIAPASTLHNWQQEISRFVPQFKVLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 218 YHGNKDDREKIFRTKMLKHLKagRPTTKFPVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKLFQQLRQFSSAT 297
Cdd:cd18002 81 YWGNPKDRKVLRKFWDRKNLY--TRDAPFHVVITSYQLVVQDEKYFQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCRN 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2033488177 298 RLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFESWFDfSDLEDEQGTEEFIadqkKQELVKKIHLILQPMLLRR 373
Cdd:cd18002 159 RLLLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFS-KDIESHAENKTGL----NEHQLKRLHMILKPFMLRR 229
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
128-375 |
5.55e-66 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 221.07 E-value: 5.55e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 128 QQPKCMINGTMRDYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIALLREQENYLGPHLIVAPLSTLSNWEDEFT 207
Cdd:cd18062 14 KQSSLLVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWVYEFD 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 208 KWTPSIPVIMYHGNKDDREkifrtKMLKHLKAGrpttKFPVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKLF 287
Cdd:cd18062 94 KWAPSVVKVSYKGSPAARR-----AFVPQLRSG----KFNVLLTTYEYIIKDKQILAKIRWKYMIVDEGHRMKNHHCKLT 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 288 QQLR-QFSSATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFESWFD--FSdledEQGTEEFIADQKKQELVKKIHL 364
Cdd:cd18062 165 QVLNtHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNapFA----MTGEKVDLNEEETILIIRRLHK 240
|
250
....*....|.
gi 2033488177 365 ILQPMLLRRIK 375
Cdd:cd18062 241 VLRPFLLRRLK 251
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
134-375 |
2.72e-65 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 217.82 E-value: 2.72e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 134 INGTMRDYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIaLLREQENYLGPHLIVAPLSTLSNWEDEFTKWTPSI 213
Cdd:cd18012 1 LKATLRPYQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALL-LSRKEEGRKGPSLVVAPTSLIYNWEEEAAKFAPEL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 214 PVIMYHGNKDDREKIFRTKmlkhlkagrpttKFPVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKLFQQLRQF 293
Cdd:cd18012 80 KVLVIHGTKRKREKLRALE------------DYDLVITSYGLLRRDIELLKEVKFHYLVLDEAQNIKNPQTKTAKAVKAL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 294 SSATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFESwfDFSDLEDEQGTEEfiadqKKQELVKKIhlilQPMLLRR 373
Cdd:cd18012 148 KADHRLALTGTPIENHLGELWSIFDFLNPGLLGSYKRFKK--RFAKPIEKDGDEE-----ALEELKKLI----SPFILRR 216
|
..
gi 2033488177 374 IK 375
Cdd:cd18012 217 LK 218
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
138-373 |
2.50e-64 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 214.99 E-value: 2.50e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 138 MRDYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIALLREQENYLGPHLIVAPLSTLSNWEDEFTKWTPSIPVIM 217
Cdd:cd18006 1 LRPYQLEGVNWLLQCRAEQHGCILGDEMGLGKTCQTISLLWYLAGRLKLLGPFLVLCPLSVLDNWKEELNRFAPDLSVIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 218 YHGnkdDREKifRTKMLKHLKAgrpTTKFPVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKLFQQLRQFSSAT 297
Cdd:cd18006 81 YMG---DKEK--RLDLQQDIKS---TNRFHVLLTTYEICLKDASFLKSFPWASLVVDEAHRLKNQNSLLHKTLSEFSVDF 152
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2033488177 298 RLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFESWFDFSDLEDEQGTeefiadqkkqelVKKIHLILQPMLLRR 373
Cdd:cd18006 153 RLLLTGTPIQNSLQELYALLSFIEPNVFPKDKLDDFIKAYSETDDESET------------VEELHLLLQPFLLRR 216
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
141-373 |
4.96e-61 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 205.37 E-value: 4.96e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 141 YQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIALLREQENYLGPHLIVAPLSTLSNWEDEFTKWTPSIPVIMYHG 220
Cdd:cd17994 4 YQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDFYVVTYVG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 221 NKddrekifrtkmlkhlkagrpttkfpVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKLFQQLRQFSSATRLL 300
Cdd:cd17994 84 DH-------------------------VLLTSYELISIDQAILGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKIGYKLL 138
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2033488177 301 ITGTPLQNNLKELWSLLHFLLPNIFTDWEAFeswfdfsdledeqgTEEFiADQKKQELVKKIHLILQPMLLRR 373
Cdd:cd17994 139 LTGTPLQNNLEELFHLLNFLTPERFNNLQGF--------------LEEF-ADISKEDQIKKLHDLLGPHMLRR 196
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
138-373 |
6.46e-59 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 201.05 E-value: 6.46e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 138 MRDYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIALLREQENYLGPHLIVAPLSTLSNWEDEFTKWTPSIPVIM 217
Cdd:cd18053 21 LRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQREIQTWAPQMNAVV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 218 YHGNKDDREKIfRTKMLKHLKAGRptTKFPVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKLFQQLRQFSSAT 297
Cdd:cd18053 101 YLGDINSRNMI-RTHEWMHPQTKR--LKFNILLTTYEILLKDKSFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNH 177
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2033488177 298 RLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFeswfdfsdlEDEQGteefiadQKKQELVKKIHLILQPMLLRR 373
Cdd:cd18053 178 RLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDF---------EEEHG-------KGREYGYASLHKELEPFLLRR 237
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
138-325 |
8.46e-58 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 196.07 E-value: 8.46e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 138 MRDYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIALLREQENYlGPHLIVAPLSTLSNWEDEFTKWTPSIPVIM 217
Cdd:cd17998 1 LKDYQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLAYLKEIGIP-GPHLVVVPSSTLDNWLREFKRWCPSLKVEP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 218 YHGNKDDREKIfRTKMLKHLkagrptTKFPVVCTSYEMVLRDQHN---LSKINWEFIIIDEGHRMKNADAKLFQQLRQFS 294
Cdd:cd17998 80 YYGSQEERKHL-RYDILKGL------EDFDVIVTTYNLATSNPDDrsfFKRLKLNYVVYDEGHMLKNMTSERYRHLMTIN 152
|
170 180 190
....*....|....*....|....*....|.
gi 2033488177 295 SATRLLITGTPLQNNLKELWSLLHFLLPNIF 325
Cdd:cd17998 153 ANFRLLLTGTPLQNNLLELMSLLNFIMPKPF 183
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
138-373 |
5.02e-56 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 192.56 E-value: 5.02e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 138 MRDYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIAllreqENYL----GPHLIVAPLSTLSNWEDEFTKWTpSI 213
Cdd:cd18058 1 LREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLS-----EIFLmgirGPFLIIAPLSTITNWEREFRTWT-EM 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 214 PVIMYHGNKDDREKIFRTKMLKHLKAGRPTT---KFPVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKLFQQL 290
Cdd:cd18058 75 NAIVYHGSQISRQMIQQYEMYYRDEQGNPLSgifKFQVVITTFEMILADCPELKKINWSCVIIDEAHRLKNRNCKLLEGL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 291 RQFSSATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFeswfdfsdledeqgTEEFiADQKKQELVKKIHLILQPML 370
Cdd:cd18058 155 KLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTF--------------LEEF-GDLKTEEQVKKLQSILKPMM 219
|
...
gi 2033488177 371 LRR 373
Cdd:cd18058 220 LRR 222
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
141-373 |
1.64e-54 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 188.68 E-value: 1.64e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 141 YQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIALLREQENYLGPHLIVAPLSTLSNWEDEFTKWTPSIPVIMYHG 220
Cdd:cd18055 4 YQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHTKGPFLVSAPLSTIINWEREFQMWAPDFYVVTYTG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 221 NKDDREKI------FRTKMLKHLKAG-----RPTTKFPVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKLFQQ 289
Cdd:cd18055 84 DKDSRAIIrenefsFDDNAVKGGKKAfkmkrEAQVKFHVLLTSYELVTIDQAALGSIRWACLVVDEAHRLKNNQSKFFRV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 290 LRQFSSATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFeswfdfsdledeqgTEEFiADQKKQELVKKIHLILQPM 369
Cdd:cd18055 164 LNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGF--------------LEEF-ADISKEDQIKKLHDLLGPH 228
|
....
gi 2033488177 370 LLRR 373
Cdd:cd18055 229 MLRR 232
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
629-758 |
4.25e-54 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 183.83 E-value: 4.25e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 629 IVTASGKMLLLDRLLPRLFQDDHKVLIFSQFTTQLDILEDYCRElRGWKVCRIDGSVAQESRRTQIADFNSDPEYKIFLL 708
Cdd:cd18793 6 EEVVSGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRE-RGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLL 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 2033488177 709 STRAGGQGINLASADTVILFDSDFNPQQDLQAQDRCHRIGQTRPVVVFRL 758
Cdd:cd18793 85 STKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRL 134
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
140-322 |
5.68e-53 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 182.91 E-value: 5.68e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 140 DYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIALLREQENYLGPHLIVAPLSTLSNWEDEFTKWTPSIPVIMYH 219
Cdd:cd18000 3 KYQQTGVQWLWELHCQRVGGILGDEMGLGKTIQIIAFLAALHHSKLGLGPSLIVCPATVLKQWVKEFHRWWPPFRVVVLH 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 220 ------GNKDDREKIFRTKMLKHLKAGRPTtkfpVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKLFQQLRQF 293
Cdd:cd18000 83 ssgsgtGSEEKLGSIERKSQLIRKVVGDGG----ILITTYEGFRKHKDLLLNHNWQYVILDEGHKIRNPDAEITLACKQL 158
|
170 180
....*....|....*....|....*....
gi 2033488177 294 SSATRLLITGTPLQNNLKELWSLLHFLLP 322
Cdd:cd18000 159 RTPHRLILSGTPIQNNLKELWSLFDFVFP 187
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
138-373 |
5.94e-53 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 184.50 E-value: 5.94e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 138 MRDYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIALLREQENYLGPHLIVAPLSTLSNWEDEFTKWTPSIPVIM 217
Cdd:cd18057 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 218 YHGNKDDR------------------EKIFRTKMLKHLkagrpttKFPVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRM 279
Cdd:cd18057 81 YTGDKESRsvirenefsfednairsgKKVFRMKKEAQI-------KFHVLLTSYELITIDQAILGSIEWACLVVDEAHRL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 280 KNADAKLFQQLRQFSSATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFeswfdfsdledeqgTEEFiADQKKQELV 359
Cdd:cd18057 154 KNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGF--------------LEEF-ADISKEDQI 218
|
250
....*....|....
gi 2033488177 360 KKIHLILQPMLLRR 373
Cdd:cd18057 219 KKLHDLLGPHMLRR 232
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
138-373 |
1.86e-52 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 183.35 E-value: 1.86e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 138 MRDYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIALL-------REQENYL-------------GPHLIVAPLS 197
Cdd:cd18005 1 LRDYQREGVEFMYDLYKNGRGGILGDDMGLGKTVQVIAFLAAVlgktgtrRDRENNRprfkkkppassakKPVLIVAPLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 198 TLSNWEDEFTKWTpSIPVIMYHGNKDDREKIFRtkmlkhLKAGRpttkFPVVCTSYEMVLRDQHNLSKINWEFIIIDEGH 277
Cdd:cd18005 81 VLYNWKDELDTWG-HFEVGVYHGSRKDDELEGR------LKAGR----LEVVVTTYDTLRRCIDSLNSINWSAVIADEAH 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 278 RMKNADAKLFQQLRQFSSATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFESwfDFSD-LEDEQ---GTEEFI--A 351
Cdd:cd18005 150 RIKNPKSKLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRSQFKK--HFSEpIKRGQrhtATARELrlG 227
|
250 260
....*....|....*....|..
gi 2033488177 352 DQKKQELVKKihliLQPMLLRR 373
Cdd:cd18005 228 RKRKQELAVK----LSKFFLRR 245
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
140-373 |
5.47e-52 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 181.42 E-value: 5.47e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 140 DYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIALLREQEnYLGPHLIVAPLSTLSNWEDEFTKWTPSIPVIMYH 219
Cdd:cd18001 3 PHQREGVAWLWSLHDGGKGGILADDMGLGKTVQICAFLSGMFDSG-LIKSVLVVMPTSLIPHWVKEFAKWTPGLRVKVFH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 220 G-NKDDREKIfrtkmLKHLKagrptTKFPVVCTSYEMVLRDQHNLSKIN-----WEFIIIDEGHRMKNADAKLFQQLRQF 293
Cdd:cd18001 82 GtSKKERERN-----LERIQ-----RGGGVLLTTYGMVLSNTEQLSADDhdefkWDYVILDEGHKIKNSKTKSAKSLREI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 294 SSATRLLITGTPLQNNLKELWSLLHFLLPNIFTdweAFESWFDfSDLED--EQGTEEFIADQKK---QELVKKIHLILQP 368
Cdd:cd18001 152 PAKNRIILTGTPIQNNLKELWALFDFACNGSLL---GTRKTFK-MEFENpiTRGRDKDATQGEKalgSEVAENLRQIIKP 227
|
....*
gi 2033488177 369 MLLRR 373
Cdd:cd18001 228 YFLRR 232
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
138-373 |
7.59e-52 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 181.02 E-value: 7.59e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 138 MRDYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIallreQENY----LGPHLIVAPLSTLSNWEDEFTKWTpSI 213
Cdd:cd18060 1 LREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFL-----QEVYnvgiHGPFLVIAPLSTITNWEREFNTWT-EM 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 214 PVIMYHGNKDDREKIFRTKMLKHLKAGR---PTTKFPVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKLFQQL 290
Cdd:cd18060 75 NTIVYHGSLASRQMIQQYEMYCKDSRGRlipGAYKFDALITTFEMILSDCPELREIEWRCVIIDEAHRLKNRNCKLLDSL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 291 RQFSSATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFESwfDFSDLedeqgteefiadqKKQELVKKIHLILQPML 370
Cdd:cd18060 155 KHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLK--DFGDL-------------KTEEQVQKLQAILKPMM 219
|
...
gi 2033488177 371 LRR 373
Cdd:cd18060 220 LRR 222
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
138-373 |
1.61e-51 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 180.26 E-value: 1.61e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 138 MRDYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIALLREQENYLGPHLIVAPLSTLSNWEDEFTKWTPSIPVIM 217
Cdd:cd18056 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 218 YHGNKDDREKI------FRTKMLK-HLKAGR----PTTKFPVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKL 286
Cdd:cd18056 81 YVGDKDSRAIIrenefsFEDNAIRgGKKASRmkkeASVKFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 287 FQQLRQFSSATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFeswfdfsdledeqgTEEFiADQKKQELVKKIHLIL 366
Cdd:cd18056 161 FRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGF--------------LEEF-ADIAKEDQIKKLHDML 225
|
....*..
gi 2033488177 367 QPMLLRR 373
Cdd:cd18056 226 GPHMLRR 232
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
138-373 |
8.05e-49 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 172.52 E-value: 8.05e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 138 MRDYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIallreQENYL----GPHLIVAPLSTLSNWEDEFTKWTpSI 213
Cdd:cd18059 1 LREYQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSITFL-----YEIYLkgihGPFLVIAPLSTIPNWEREFRTWT-EL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 214 PVIMYHGNKDDREKIFRTKMLKHLKAGR---PTTKFPVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKLFQQL 290
Cdd:cd18059 75 NVVVYHGSQASRRTIQLYEMYFKDPQGRvikGSYKFHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 291 RQFSSATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFeswfdfsdledeqgTEEFiADQKKQELVKKIHLILQPML 370
Cdd:cd18059 155 KMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTF--------------MQEF-GDLKTEEQVQKLQAILKPMM 219
|
...
gi 2033488177 371 LRR 373
Cdd:cd18059 220 LRR 222
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
138-373 |
2.33e-48 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 170.96 E-value: 2.33e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 138 MRDYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIallreQENYL----GPHLIVAPLSTLSNWEDEFTKWTpSI 213
Cdd:cd18061 1 LREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFL-----YEILLtgirGPFLIIAPLSTIANWEREFRTWT-DL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 214 PVIMYHGNKDDREKIFRTKMLKHLKAGR---PTTKFPVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKLFQQL 290
Cdd:cd18061 75 NVVVYHGSLISRQMIQQYEMYFRDSQGRiirGAYRFQAIITTFEMILGGCPELNAIDWRCVIIDEAHRLKNKNCKLLEGL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 291 RQFSSATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFeswfdfsdledeqgTEEFiADQKKQELVKKIHLILQPML 370
Cdd:cd18061 155 KLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTF--------------MQEF-GDLKTEEQVQKLQAILKPMM 219
|
...
gi 2033488177 371 LRR 373
Cdd:cd18061 220 LRR 222
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
139-373 |
4.98e-48 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 170.93 E-value: 4.98e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 139 RDYQLEGLTWMyeiCSQGmsGILADEMGLGKTVQTIALIALLREQENYLGPH-----------------LIVAPLSTLSN 201
Cdd:cd18008 2 LPYQKQGLAWM---LPRG--GILADEMGLGKTIQALALILATRPQDPKIPEEleenssdpkklylskttLIVVPLSLLSQ 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 202 WEDEFTK--WTPSIPVIMYHGNKddrekifRTKMLKHLKagrpttKFPVVCTSYEMVLRD--QHN--------------L 263
Cdd:cd18008 77 WKDEIEKhtKPGSLKVYVYHGSK-------RIKSIEELS------DYDIVITTYGTLASEfpKNKkgggrdskekeaspL 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 264 SKINWEFIIIDEGHRMKNADAKLFQQLRQFSSATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFESWFDFSDLEDE 343
Cdd:cd18008 144 HRIRWYRVILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFNSDISKPFSKND 223
|
250 260 270
....*....|....*....|....*....|
gi 2033488177 344 QGTeefiadqkkqelVKKIHLILQPMLLRR 373
Cdd:cd18008 224 RKA------------LERLQALLKPILLRR 241
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
138-373 |
4.08e-47 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 167.91 E-value: 4.08e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 138 MRDYQLEGLTWMYEICSQGMSGILADEMGLGKTVQTIALIAL---LREQENYLG--PHLIVAPLSTLSNWEDEFTKWTP- 211
Cdd:cd17999 1 LRPYQQEGINWLAFLNKYNLHGILCDDMGLGKTLQTLCILASdhhKRANSFNSEnlPSLVVCPPTLVGHWVAEIKKYFPn 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 212 -SIPVIMYHGNKDDREKIfRTKMLKHlkagrpttkfPVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKLFQQL 290
Cdd:cd17999 81 aFLKPLAYVGPPQERRRL-REQGEKH----------NVIVASYDVLRNDIEVLTKIEWNYCVLDEGHIIKNSKTKLSKAV 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 291 RQFSSATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFESWF--DFSDLEDEQGTEEFIADQKKQelVKKIHLILQP 368
Cdd:cd17999 150 KQLKANHRLILSGTPIQNNVLELWSLFDFLMPGYLGTEKQFQRRFlkPILASRDSKASAKEQEAGALA--LEALHKQVLP 227
|
....*
gi 2033488177 369 MLLRR 373
Cdd:cd17999 228 FLLRR 232
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
138-373 |
5.57e-45 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 162.07 E-value: 5.57e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 138 MRDYQLEGLTWMYEiCSQGMSG------ILADEMGLGKTVQTIALIALLREQENYLGPH----LIVAPLSTLSNWEDEFT 207
Cdd:cd18004 1 LRPHQREGVQFLYD-CLTGRRGyggggaILADEMGLGKTLQAIALVWTLLKQGPYGKPTakkaLIVCPSSLVGNWKAEFD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 208 KWTPS--IPVIMYHGNKDDREKIfrtkmLKHLKAGRPttkFPVVCTSYEMVLRDQHNLSK-INWEFIIIDEGHRMKNADA 284
Cdd:cd18004 80 KWLGLrrIKVVTADGNAKDVKAS-----LDFFSSAST---YPVLIISYETLRRHAEKLSKkISIDLLICDEGHRLKNSES 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 285 KLFQQLRQFSSATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFESWFDFSDLE--DEQGTEEFI--ADQKKQELVK 360
Cdd:cd18004 152 KTTKALNSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPILRsrDPDASEEDKelGAERSQELSE 231
|
250
....*....|...
gi 2033488177 361 kihlILQPMLLRR 373
Cdd:cd18004 232 ----LTSRFILRR 240
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
138-335 |
6.95e-38 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 141.66 E-value: 6.95e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 138 MRDYQLEGLTWMYEICSQGMSG-------ILADEMGLGKTVQTIALI-ALLREQENYLGPhLIVAPLSTLSNWEDEFTKW 209
Cdd:cd18007 1 LKPHQVEGVRFLWSNLVGTDVGsdegggcILAHTMGLGKTLQVITFLhTYLAAAPRRSRP-LVLCPASTLYNWEDEFKKW 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 210 TPSIPVIMYHGNKDDREKIF--RTKMLK--HLKAGrpttkfpVVCTSYEM---VLRDQHNLSKINWEF-----------I 271
Cdd:cd18007 80 LPPDLRPLLVLVSLSASKRAdaRLRKINkwHKEGG-------VLLIGYELfrnLASNATTDPRLKQEFiaalldpgpdlL 152
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2033488177 272 IIDEGHRMKNADAKLFQQLRQFSSATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFESWF 335
Cdd:cd18007 153 VLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGTLKEFKKKF 216
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
138-373 |
3.49e-36 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 137.22 E-value: 3.49e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 138 MRDYQLEGLTWMYEiCSQGMSG------ILADEMGLGKTVQTIALIALLREQENYLGPHL----IVAPLSTLSNWEDEFT 207
Cdd:cd18067 1 LRPHQREGVKFLYR-CVTGRRIrgshgcIMADEMGLGKTLQCITLMWTLLRQSPQCKPEIdkaiVVSPSSLVKNWANELG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 208 KWTPS--IPVIMYHGNKDDREKIFRTKMLKHlkaGRPTTKfPVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAK 285
Cdd:cd18067 80 KWLGGrlQPLAIDGGSKKEIDRKLVQWASQQ---GRRVST-PVLIISYETFRLHVEVLQKGEVGLVICDEGHRLKNSDNQ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 286 LFQQLRQFSSATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFESWFDFSDLE--DEQGTEEFI--ADQKKQELVKk 361
Cdd:cd18067 156 TYQALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNFELPILKgrDADASEKERqlGEEKLQELIS- 234
|
250
....*....|..
gi 2033488177 362 ihlILQPMLLRR 373
Cdd:cd18067 235 ---IVNRCIIRR 243
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
138-373 |
9.12e-36 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 135.74 E-value: 9.12e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 138 MRDYQLEGLTWMYEiCSQGM------SGILADEMGLGKTVQTIALIALLREQENY-----LGPHLIVAPLSTLSNWEDEF 206
Cdd:cd18066 1 LRPHQREGIEFLYE-CVMGMrvnerfGAILADEMGLGKTLQCISLIWTLLRQGPYggkpvIKRALIVTPGSLVKNWKKEF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 207 TKWTPSipvimyhgnkdDREKIFRTKMLKHLKAGRPTTKFPVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKL 286
Cdd:cd18066 80 QKWLGS-----------ERIKVFTVDQDHKVEEFIASPLYSVLIISYEMLLRSLDQISKLNFDLVICDEGHRLKNTSIKT 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 287 FQQLRQFSSATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFESWFDFSDLEDEQGT----EEFIADQKKQELVKKI 362
Cdd:cd18066 149 TTALTSLSCERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVYEEPIVRSREPTatpeEKKLGEARAAELTRLT 228
|
250
....*....|.
gi 2033488177 363 HLilqpMLLRR 373
Cdd:cd18066 229 GL----FILRR 235
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
140-331 |
9.18e-32 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 123.08 E-value: 9.18e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 140 DYQLEGLTWmyeICSQGMSGILADEMGLGKTVQTIALIALLREQenylGPHLIVAPLSTLSNWEDEFTKWTPSIP---VI 216
Cdd:cd18010 3 PFQREGVCF---ALRRGGRVLIADEMGLGKTVQAIAIAAYYREE----WPLLIVCPSSLRLTWADEIERWLPSLPpddIQ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 217 MYHGNKDDrekifrtkmlkhLKAGRPTtkfpVVCTSYEMVLRDQHNLSKINWEFIIIDEGHRMKNADAKLFQQLRQFSSA 296
Cdd:cd18010 76 VIVKSKDG------------LRDGDAK----VVIVSYDLLRRLEKQLLARKFKVVICDESHYLKNSKAKRTKAALPLLKR 139
|
170 180 190
....*....|....*....|....*....|....*..
gi 2033488177 297 TR--LLITGTPLQNNLKELWSLLHFLLPNIFTDWEAF 331
Cdd:cd18010 140 AKrvILLSGTPALSRPIELFTQLDALDPKLFGRFHDF 176
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
159-320 |
1.35e-31 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 123.73 E-value: 1.35e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 159 GILADEMGLGKTVQTIALIALlreqenylGPHLIVAPLSTLSNWEDEFTKWTPS--IPVIMYHGNkddrEKIFRTKMLkh 236
Cdd:cd18071 51 GILADDMGLGKTLTTISLILA--------NFTLIVCPLSVLSNWETQFEEHVKPgqLKVYTYHGG----ERNRDPKLL-- 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 237 lkagrptTKFPVVCTSYEMVLRD-----QHNLSKINWEFIIIDEGHRMKNADAKLFQQLRQFSSATRLLITGTPLQNNLK 311
Cdd:cd18071 117 -------SKYDIVLTTYNTLASDfgakgDSPLHTINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPK 189
|
....*....
gi 2033488177 312 ELWSLLHFL 320
Cdd:cd18071 190 DLGSLLSFL 198
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
137-326 |
3.55e-30 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 118.36 E-value: 3.55e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 137 TMRDYQLEGLTWMYEIcsqGMSGILADEMGLGKTVQtIALIALLREQENYLGPHLIVAPLSTL-SNWEDEFTKWTPS--- 212
Cdd:smart00487 8 PLRPYQKEAIEALLSG---LRDVILAAPTGSGKTLA-ALLPALEALKRGKGGRVLVLVPTRELaEQWAEELKKLGPSlgl 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 213 IPVIMYHGNKddrekifRTKMLKHLKAGRPttkfPVVCTSYEMVLRD--QHNLSKINWEFIIIDEGHRMKNAD-----AK 285
Cdd:smart00487 84 KVVGLYGGDS-------KREQLRKLESGKT----DILVTTPGRLLDLleNDKLSLSNVDLVILDEAHRLLDGGfgdqlEK 152
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 2033488177 286 LFQQLRqfSSATRLLITGTP---LQNNLKELWSLLHFLLPNIFT 326
Cdd:smart00487 153 LLKLLP--KNVQLLLLSATPpeeIENLLELFLNDPVFIDVGFTP 194
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
648-748 |
5.32e-26 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 103.06 E-value: 5.32e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 648 QDDHKVLIFSQFTTQLDilEDYCRELRGWKVCRIDGSVAQESRRTQIADFNsDPEYKIfLLSTRAGGQGINLASADTVIL 727
Cdd:pfam00271 13 ERGGKVLIFSQTKKTLE--AELLLEKEGIKVARLHGDLSQEEREEILEDFR-KGKIDV-LVATDVAERGLDLPDVDLVIN 88
|
90 100
....*....|....*....|.
gi 2033488177 728 FDSDFNPQQDLQAQDRCHRIG 748
Cdd:pfam00271 89 YDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
141-336 |
9.44e-26 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 106.44 E-value: 9.44e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 141 YQLEGLTWMYEIC---------SQGMSGILADEMGLGKTVQTIALIALLReQENYLGPHLIVAPLSTLSNWEDEFTKWTP 211
Cdd:cd18069 4 HQIGGIRFLYDNIieslerykgSSGFGCILAHSMGLGKTLQVISFLDVLL-RHTGAKTVLAIVPVNTLQNWLSEFNKWLP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 212 SipvimYHGNKDDREKIFRTKML----KHLKAGRP-----TTKFPVVCTSYEMV-LRDQHNLskinwefIIIDEGHRMKN 281
Cdd:cd18069 83 P-----PEALPNVRPRPFKVFILndehKTTAARAKviedwVKDGGVLLMGYEMFrLRPGPDV-------VICDEGHRIKN 150
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 2033488177 282 ADAKLFQQLRQFSSATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFESWFD 336
Cdd:cd18069 151 CHASTSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFE 205
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
141-373 |
2.55e-25 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 105.64 E-value: 2.55e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 141 YQLEGLTWMYEICSQGMSG-ILADEMGLGKTVQTIALIALLREQENYLGPH----------------------LIVAPLS 197
Cdd:cd18072 4 HQKQALAWLLWRERQKPRGgILADDMGLGKTLTMIALILAQKNTQNRKEEEkekalteweskkdstlvpsagtLVVCPAS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 198 TLSNWEDEFTKWTPS--IPVIMYHG-NKDDREKIFRTkmlkhlkagrpttkFPVVCTSYEMVLRD---------QHNLSK 265
Cdd:cd18072 84 LVHQWKNEVESRVASnkLRVCLYHGpNRERIGEVLRD--------------YDIVITTYSLVAKEiptykeesrSSPLFR 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 266 INWEFIIIDEGHRMKNADAKLFQQLRQFSSATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFESWFdfsDLEDEQG 345
Cdd:cd18072 150 IAWARIILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFLRCSPFDDLKVWKKQV---DNKSRKG 226
|
250 260
....*....|....*....|....*...
gi 2033488177 346 TEefiadqkkqelvkKIHLILQPMLLRR 373
Cdd:cd18072 227 GE-------------RLNILTKSLLLRR 241
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
138-343 |
2.76e-25 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 104.29 E-value: 2.76e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 138 MRDYQLEGLtwmYEICSQGMSG-ILADEMGLGKTVQTIALIALLrEQENYLGPHLIVAPLSTLSNWEDE-FTKWTPSIPV 215
Cdd:cd18011 1 PLPHQIDAV---LRALRKPPVRlLLADEVGLGKTIEAGLIIKEL-LLRGDAKRVLILCPASLVEQWQDElQDKFGLPFLI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 216 ImyhgnkdDREKIFRTKMLkhlkAGRPTTKFPVVCTSYEMVLRD---QHNLSKINWEFIIIDEGHRMKNA----DAKLFQ 288
Cdd:cd18011 77 L-------DRETAAQLRRL----IGNPFEEFPIVIVSLDLLKRSeerRGLLLSEEWDLVVVDEAHKLRNSgggkETKRYK 145
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 2033488177 289 QLRQFSSATR--LLITGTPLQNNLKELWSLLHFLlpniftDWEAFESWFDFSDLEDE 343
Cdd:cd18011 146 LGRLLAKRARhvLLLTATPHNGKEEDFRALLSLL------DPGRFAVLGRFLRLDGL 196
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
138-335 |
6.63e-25 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 104.58 E-value: 6.63e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 138 MRDYQLEGLTWMYEIC---------SQGMSGILADEMGLGKTVQTIALI--ALLREQENYLGPHLIVAPLSTLSNWEDEF 206
Cdd:cd18068 1 LKPHQVDGVQFMWDCCceslkktkkSPGSGCILAHCMGLGKTLQVVTFLhtVLLCEKLENFSRVLVVCPLNTVLNWLNEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 207 TKWTpsipvimyHGNKDDrEKI-------FRTKMLKHLKAGRPTTKFPVVCTSYEMV--------------LRDQHNLSK 265
Cdd:cd18068 81 EKWQ--------EGLKDE-EKIevnelatYKRPQERSYKLQRWQEEGGVMIIGYDMYrilaqernvksrekLKEIFNKAL 151
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2033488177 266 INW--EFIIIDEGHRMKNADAKLFQQLRQFSSATRLLITGTPLQNNLKELWSLLHFLLPNIFTDWEAFESWF 335
Cdd:cd18068 152 VDPgpDFVVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRF 223
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
664-748 |
4.86e-21 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 88.04 E-value: 4.86e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 664 DILEDYCRElRGWKVCRIDGSVAQESRRTQIADFNSDPeyKIFLLSTRAGGQGINLASADTVILFDSDFNPQQDLQAQDR 743
Cdd:smart00490 1 EELAELLKE-LGIKVARLHGGLSQEEREEILDKFNNGK--IKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGR 77
|
....*
gi 2033488177 744 CHRIG 748
Cdd:smart00490 78 AGRAG 82
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
138-337 |
5.52e-20 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 90.48 E-value: 5.52e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 138 MRDYQLEGLTWMyeICSQGmsgILADEMGLGKTVQTIALIALLREQEN-------------------------YLGPHLI 192
Cdd:cd18070 1 LLPYQRRAVNWM--LVPGG---ILADEMGLGKTVEVLALILLHPRPDNdldaadddsdemvccpdclvaetpvSSKATLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 193 VAPLSTLSNWEDEFTKWTP-SIPVIMYHGNKDDrekifrtkMLKHLKAGRPTTKFPVVCTSYEmVLRDQ-------HN-- 262
Cdd:cd18070 76 VCPSAILAQWLDEINRHVPsSLKVLTYQGVKKD--------GALASPAPEILAEYDIVVTTYD-VLRTElhyaeanRSnr 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 263 --------------LSKINWEFIIIDEGHRMKNADAKLFQQLRQFSSATRLLITGTPLQNNLKELWSLLHFLLPNIFTDw 328
Cdd:cd18070 147 rrrrqkryeappspLVLVEWWRVCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSFLGVEPFCD- 225
|
....*....
gi 2033488177 329 eafESWFDF 337
Cdd:cd18070 226 ---SDWWAR 231
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
138-362 |
2.13e-15 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 76.23 E-value: 2.13e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 138 MRDYQLEGLTWmyeICSQGMSGILADeMGLGKTVQTIALIALLREqENYLGPHLIVAPLSTLSN-WEDEFTKWtpSIPVI 216
Cdd:cd18013 1 PHPYQKVAINF---IIEHPYCGLFLD-MGLGKTVTTLTALSDLQL-DDFTRRVLVIAPLRVARStWPDEVEKW--NHLRN 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 217 MYHGNKDDREKIfRTKMLkhlkagrpTTKFPVVCTSYEMvLRDQHNLSKINWEF--IIIDEGHRMKNADAKLFQQLRQFS 294
Cdd:cd18013 74 LTVSVAVGTERQ-RSKAA--------NTPADLYVINREN-LKWLVNKSGDPWPFdmVVIDELSSFKSPRSKRFKALRKVR 143
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2033488177 295 SATRLLI--TGTPLQNNLKELWSLLHFL-----LPNIFTdweAF-ESWFDFSDLEDEQGTEEFIADQKKQELVKKI 362
Cdd:cd18013 144 PVIKRLIglTGTPSPNGLMDLWAQIALLdqgerLGRSIT---AYrERWFDPDKRNGQQVFKYKPKPGAEEEIYRAI 216
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
137-305 |
1.22e-10 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 60.76 E-value: 1.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 137 TMRDYQLEGLT-WMYEICSQGMSGILADEMGLGKTVQTIALIALLREQENYLgPHLIVAP-LSTLSNWEDEFTKWTPSIP 214
Cdd:pfam04851 3 ELRPYQIEAIEnLLESIKNGQKRGLIVMATGSGKTLTAAKLIARLFKKGPIK-KVLFLVPrKDLLEQALEEFKKFLPNYV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 215 VIM--YHGNKDDREKifrtkmlkhlkagrptTKFPVVCTSYEMVLRDQHN----LSKINWEFIIIDEGHRmknADAKLFQ 288
Cdd:pfam04851 82 EIGeiISGDKKDESV----------------DDNKIVVTTIQSLYKALELasleLLPDFFDVIIIDEAHR---SGASSYR 142
|
170
....*....|....*...
gi 2033488177 289 Q-LRQFSSATRLLITGTP 305
Cdd:pfam04851 143 NiLEYFKPAFLLGLTATP 160
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
135-305 |
7.74e-10 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 62.35 E-value: 7.74e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 135 NGTMRDYQLEGL-TWMYEICSQGMSGILADEMGLGKTVQTIALIALLREQENYLgphlIVAPLSTLSN-WEDEFTKWTPS 212
Cdd:COG1061 78 SFELRPYQQEALeALLAALERGGGRGLVVAPTGTGKTVLALALAAELLRGKRVL----VLVPRRELLEqWAEELRRFLGD 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 213 IPVimyHGNKDDREkifrtkmlkhlkagrpttkFPVVCTSYEMVLRDQHnLSKI--NWEFIIIDEGHRmknADAKLFQQ- 289
Cdd:COG1061 154 PLA---GGGKKDSD-------------------APITVATYQSLARRAH-LDELgdRFGLVIIDEAHH---AGAPSYRRi 207
|
170
....*....|....*.
gi 2033488177 290 LRQFSSATRLLITGTP 305
Cdd:COG1061 208 LEAFPAAYRLGLTATP 223
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
138-305 |
4.96e-09 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 55.77 E-value: 4.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 138 MRDYQLEGLTWMYEICSQGmSGILADEMGLGKTVQTIALIALLREQenylgPHLIVAP-LSTLSNWEDEFTKWTPSIPVi 216
Cdd:cd17926 1 LRPYQEEALEAWLAHKNNR-RGILVLPTGSGKTLTALALIAYLKEL-----RTLIVVPtDALLDQWKERFEDFLGDSSI- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 217 myhgnkddreKIFRTKMLKHLkagrptTKFPVVCTSYEMVLRDQHNLSKI--NWEFIIIDEGHRmknADAKLFQQ-LRQF 293
Cdd:cd17926 74 ----------GLIGGGKKKDF------DDANVVVATYQSLSNLAEEEKDLfdQFGLLIVDEAHH---LPAKTFSEiLKEL 134
|
170
....*....|..
gi 2033488177 294 SSATRLLITGTP 305
Cdd:cd17926 135 NAKYRLGLTATP 146
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
156-304 |
8.25e-09 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 55.10 E-value: 8.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 156 GMSGILADEMGLGKTvqTIALIALLREQENYLGPHLIVAPLSTLSN-WEDEFTKW-TPSIPVIMYHGNKDDREKIFRTKM 233
Cdd:cd00046 1 GENVLITAPTGSGKT--LAALLAALLLLLKKGKKVLVLVPTKALALqTAERLRELfGPGIRVAVLVGGSSAEEREKNKLG 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2033488177 234 LKHLkagrpttkfpVVCTsYEMVLRD---QHNLSKINWEFIIIDEGHRMKNADAKLFQ-----QLRQFSSATRLLITGT 304
Cdd:cd00046 79 DADI----------IIAT-PDMLLNLllrEDRLFLKDLKLIIVDEAHALLIDSRGALIldlavRKAGLKNAQVILLSAT 146
|
|
| DEXHc_XPB |
cd18029 |
DEXH-box helicase domain of TFIIH XPB subunit and similar proteins; TFIIH basal transcription ... |
139-304 |
7.63e-06 |
|
DEXH-box helicase domain of TFIIH XPB subunit and similar proteins; TFIIH basal transcription factor complex helicase XPB subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350787 [Multi-domain] Cd Length: 169 Bit Score: 46.91 E-value: 7.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 139 RDYQLEGLTWMYEiCSQGMSGILADEMGLGKTVQTIALIALLREQEnylgphLIVAPlSTLS--NWEDEFTKWTpSIPVI 216
Cdd:cd18029 10 RPYQEKALSKMFG-NGRARSGVIVLPCGAGKTLVGITAACTIKKST------LVLCT-SAVSveQWRRQFLDWT-TIDDE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 217 MYHGNKDDREKIFRTKmlkhlkagrpttkfPVVCTSYEMVL---RDQHNLSKIN-------WEFIIIDEGHRMKnadAKL 286
Cdd:cd18029 81 QIGRFTSDKKEIFPEA--------------GVTVSTYSMLAntrKRSPESEKFMefitereWGLIILDEVHVVP---APM 143
|
170
....*....|....*....
gi 2033488177 287 FQQ-LRQFSSATRLLITGT 304
Cdd:cd18029 144 FRRvLTLQKAHCKLGLTAT 162
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
647-750 |
1.24e-03 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 42.45 E-value: 1.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033488177 647 FQDDHKVLIFSQFTTQLDILedyCRELR--GWKVCRIDGSVAQESRRTQIADFNS--DPeykiFLLSTRAGGQGINLASA 722
Cdd:PTZ00110 374 MRDGDKILIFVETKKGADFL---TKELRldGWPALCIHGDKKQEERTWVLNEFKTgkSP----IMIATDVASRGLDVKDV 446
|
90 100
....*....|....*....|....*...
gi 2033488177 723 DTVILFDSdfnPQqdlQAQDRCHRIGQT 750
Cdd:PTZ00110 447 KYVINFDF---PN---QIEDYVHRIGRT 468
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
706-758 |
1.57e-03 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 38.07 E-value: 1.57e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 2033488177 706 FLLSTRAGGQGINLASADTVILFDSDFNPQQDLQAQDRCHRIGQtRPVVVFRL 758
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGK-DEGEVILF 76
|
|
| |
