|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
60-497 |
1.45e-150 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 438.93 E-value: 1.45e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 60 EAAALCRLAFPIALTALLLYSRTALSMLFLGSIGDLPLAAGSLAVAFANITGYSVLSGLSLGMDPLCSQAFGANQARLLG 139
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 140 LTLYRSVLFLLCCSLPLSALWLNMSKILVFLGQDREITALAQEYILFSLPDLFSFSIIHPLRVYLRSQGITRPLAAAAAA 219
Cdd:cd13132 81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 220 AVLFHVPANYVLVGRLGLGAPGVAAAASASNFVLLGVLLAYVAGRRDaALLAAGPPTVEWLAGWGPLARLAAPSCVSVCL 299
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKG-HKATWGGFSREAFRGWGPFLKLAIPSALMLCL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 300 EWWWYEVMILLCGLLPdPKPAVASMGVLMQTTALVYVFPSSLGFGVSTRVGNELGANRPGRARAAAHVAVAGATGMGLAA 379
Cdd:cd13132 240 EWWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 380 MSFAAGVRHAWGRMFTADADILRLTAAALPIVGLCELGNCPQTVGCGVLRGSARPTRAAHVNLGAFYLVGMPVAVLLAFG 459
Cdd:cd13132 319 AILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFV 398
|
410 420 430
....*....|....*....|....*....|....*...
gi 1981903693 460 LGVGFVGLWMGLLAAQVCCAGLMLCVVGSTDWEAQARR 497
Cdd:cd13132 399 LGLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
63-483 |
6.36e-46 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 166.86 E-value: 6.36e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 63 ALCRLAFPIALTALLLYSRTALSMLFLGSIGDLPLAAGSLAVAFANITgYSVLSGLSLGMDPLCSQAFGANQARLLGLTL 142
Cdd:COG0534 9 LLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLL-IALGIGLGVGGTALVAQALGAGDREEARRVL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 143 YRSVLFLLCCSLPLSAL-WLNMSKILVFLGQDREITALAQEYILFSLPDLFSFSIIHPLRVYLRSQGITRPLAAAAAAAV 221
Cdd:COG0534 88 GQALLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIGN 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 222 LFHVPANYVLVGRLGLGAPGVAAAASASNFVLLGVLLAYVAGRRDAALLAAGPPTVEWlAGWGPLARLAAPSCVSVCLEW 301
Cdd:COG0534 168 VLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDR-KILKRILRIGLPAGLQQLAES 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 302 WWYEVMILLCGLLPDPkpAVASMGVLMQTTALVYVFPSSLGFGVSTRVGNELGANRPGRARAAAHVAVAGATGMGLAAMS 381
Cdd:COG0534 247 LGFLVLNALVARLGTA--AVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLAL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 382 FAAGVRHAWGRMFTADADILRLTAAALPIVGLCELGNCPQTVGCGVLRGSARPTRAAHVNLGAFYLVGMPVAVLLAFgLG 461
Cdd:COG0534 325 LLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAF-LG 403
|
410 420
....*....|....*....|..
gi 1981903693 462 VGFVGLWMGLLAAQVCCAGLML 483
Cdd:COG0534 404 LGLTGVWLALPIGEVLRALLLL 425
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
70-412 |
1.54e-37 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 141.61 E-value: 1.54e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 70 PIALTALLLYSRTALSMLFLGSIGDLPLAAGSLAvAFANITGYSVLSGLSLGMDPLCSQAFGANQARLLGLTLYRSVLFL 149
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLG-SSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 150 LCCSLPLSALWLNMSKILVFLGQ-DREITALAQEYILFSLPDLFSFSIIHPLRVYLRSQGITRPLAAAAAAAVLFHVPAN 228
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGaDGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 229 YVLV-GRLG-LGAPGVAAAASASNFVLLGVLLAYVAGRRDAALLAAGPPTvEWLAGWGPLARLAAPSCVSVCLEWWWYEV 306
Cdd:TIGR00797 160 YILIfGKFGfLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLK-PDWEVLKRLLKLGLPIAFRVILESLSFAL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 307 MILLCGLLPDPkpAVASMGVLMQTTALVYVFPSSLGFGVSTRVGNELGANRPGRARAAAHVAVAGATGMGLAAMSFAAGV 386
Cdd:TIGR00797 239 LALLVARLGSI--ALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILF 316
|
330 340
....*....|....*....|....*.
gi 1981903693 387 RHAWGRMFTADADILRLTAAALPIVG 412
Cdd:TIGR00797 317 REFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
70-230 |
2.44e-29 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 113.43 E-value: 2.44e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 70 PIALTALLLYSRTALSMLFLGSIGDLPLAAGSLAVAFANITgYSVLSGLSLGMDPLCSQAFGANQARLLGLTLYRSVLFL 149
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLI-FMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 150 LCCSLPLSAL-WLNMSKILVFLGQDREITALAQEYILFSLPDLFSFSIIHPLRVYLRSQGITRPLAAAAAAAVLFHVPAN 228
Cdd:pfam01554 80 LLLSLPIALLvLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 1981903693 229 YV 230
Cdd:pfam01554 160 YL 161
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
60-483 |
5.78e-20 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 92.57 E-value: 5.78e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 60 EAAALCRLAFPIALTALLLYSRTALSMLFLGSIGDLPLAAGSLAVAFAnITGYSVLSGLSLGMDPLCSQAFGANQARLLG 139
Cdd:PRK01766 10 EARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSIW-LPVILFGHGLLLALTPIVAQLNGAGRRERIA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 140 LTLYRSVLFLLCCSLPLSA-LWLNMSKILVFLGQDREITALAQEY---ILFSLPDLFSFSIihpLRVYLRSQGITRPLAA 215
Cdd:PRK01766 89 HQVRQGLWLALFLSVLIMLvLYNAVPPILNMMNLEPEVADIAVGYlhaLLWGIPAYLLYQV---LRSFIDGLGKTKPTMV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 216 AAAAAVLFHVPANYVLV-GRLG---LGAPGVAAAASASNFVLLGVLLAYVA-GRRDAAL-LAAGPPTVEWLAgWGPLARL 289
Cdd:PRK01766 166 IGFLGLLINIPLNYIFIyGKFGfpeLGGVGCGVATAIVYWVMFLAMLIYIKrARRFRDFrLFKGLYKPDWAV-IKRLLKL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 290 AAPSCVSVCLEWWWYEVMILLCGLLPDPkpAVASMGVLMQTTALVYVFPSSLGFGVSTRVGNELGANRPGRARAAAHVAV 369
Cdd:PRK01766 245 GLPIGLAIFFEVSLFAVVTLLVSPLGTV--TVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAYIGL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 370 AGATGMGLAAMSFAAGVRHAWGRMFTADADILRLTAAALPIVGLCELGNCPQTVGCGVLRGsARPTRAA-HVNLGAFYLV 448
Cdd:PRK01766 323 AVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRG-YKDTRVIfFITFIAYWVL 401
|
410 420 430
....*....|....*....|....*....|....*
gi 1981903693 449 GMPVAVLLAFGLGVGFVGLWMGLLAAQVCCAGLML 483
Cdd:PRK01766 402 GLPLGYILALTDPMGPFGFWIGLIIGLTAAAILLL 436
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
60-497 |
1.45e-150 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 438.93 E-value: 1.45e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 60 EAAALCRLAFPIALTALLLYSRTALSMLFLGSIGDLPLAAGSLAVAFANITGYSVLSGLSLGMDPLCSQAFGANQARLLG 139
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 140 LTLYRSVLFLLCCSLPLSALWLNMSKILVFLGQDREITALAQEYILFSLPDLFSFSIIHPLRVYLRSQGITRPLAAAAAA 219
Cdd:cd13132 81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 220 AVLFHVPANYVLVGRLGLGAPGVAAAASASNFVLLGVLLAYVAGRRDaALLAAGPPTVEWLAGWGPLARLAAPSCVSVCL 299
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKG-HKATWGGFSREAFRGWGPFLKLAIPSALMLCL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 300 EWWWYEVMILLCGLLPdPKPAVASMGVLMQTTALVYVFPSSLGFGVSTRVGNELGANRPGRARAAAHVAVAGATGMGLAA 379
Cdd:cd13132 240 EWWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 380 MSFAAGVRHAWGRMFTADADILRLTAAALPIVGLCELGNCPQTVGCGVLRGSARPTRAAHVNLGAFYLVGMPVAVLLAFG 459
Cdd:cd13132 319 AILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFV 398
|
410 420 430
....*....|....*....|....*....|....*...
gi 1981903693 460 LGVGFVGLWMGLLAAQVCCAGLMLCVVGSTDWEAQARR 497
Cdd:cd13132 399 LGLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
60-483 |
1.40e-48 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 174.22 E-value: 1.40e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 60 EAAALCRLAFPIALTALLLYSRTALSMLFLGSIGDLPLAAGSLAVAFaNITGYSVLSGLSLGMDPLCSQAFGANQARLLG 139
Cdd:cd13131 1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSL-WFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 140 LTLYRSVLFLLCCSLPLSALWLNMSKILVFLGQDREITALAQEYILFSLPDLFSFSIIHPLRVYLRSQGITRPLAAAAAA 219
Cdd:cd13131 80 RAVRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 220 AVLFHVPANYVLV-GRLG---LGAPGVAAAASASNFVLLGVLLAYVAGRRDAA--LLAAGPPTVEWLAgWGPLARLAAPS 293
Cdd:cd13131 160 ALVLNIPLNYVLIfGKFGlpaLGGAGAGLATAIVYWLMFLALAFYIRRHKRFRryRLFARFWRPDWAR-LKELLRLGLPI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 294 CVSVCLEWWWYEVMILLCGLLPDpkPAVASMGVLMQTTALVYVFPSSLGFGVSTRVGNELGANRPGRARAAAHVAVAGAT 373
Cdd:cd13131 239 GLTIFFEVSLFAAVALLMGRLGT--TVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGLGV 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 374 GMGLAAMSFAAGVRHAWGRMFTADADILRLTAAALPIVGLCELGNCPQTVGCGVLRGsARPTRA-AHVNLGAFYLVGMPV 452
Cdd:cd13131 317 GFAALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRG-YKDTRVpFLLALISYWGIGLPL 395
|
410 420 430
....*....|....*....|....*....|.
gi 1981903693 453 AVLLAFGLGVGFVGLWMGLLAAQVCCAGLML 483
Cdd:cd13131 396 GYLLAFTTGLGAFGVWIGLIIGLALAAILLL 426
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
63-483 |
6.36e-46 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 166.86 E-value: 6.36e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 63 ALCRLAFPIALTALLLYSRTALSMLFLGSIGDLPLAAGSLAVAFANITgYSVLSGLSLGMDPLCSQAFGANQARLLGLTL 142
Cdd:COG0534 9 LLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLL-IALGIGLGVGGTALVAQALGAGDREEARRVL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 143 YRSVLFLLCCSLPLSAL-WLNMSKILVFLGQDREITALAQEYILFSLPDLFSFSIIHPLRVYLRSQGITRPLAAAAAAAV 221
Cdd:COG0534 88 GQALLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIGN 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 222 LFHVPANYVLVGRLGLGAPGVAAAASASNFVLLGVLLAYVAGRRDAALLAAGPPTVEWlAGWGPLARLAAPSCVSVCLEW 301
Cdd:COG0534 168 VLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDR-KILKRILRIGLPAGLQQLAES 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 302 WWYEVMILLCGLLPDPkpAVASMGVLMQTTALVYVFPSSLGFGVSTRVGNELGANRPGRARAAAHVAVAGATGMGLAAMS 381
Cdd:COG0534 247 LGFLVLNALVARLGTA--AVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLAL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 382 FAAGVRHAWGRMFTADADILRLTAAALPIVGLCELGNCPQTVGCGVLRGSARPTRAAHVNLGAFYLVGMPVAVLLAFgLG 461
Cdd:COG0534 325 LLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAF-LG 403
|
410 420
....*....|....*....|..
gi 1981903693 462 VGFVGLWMGLLAAQVCCAGLML 483
Cdd:COG0534 404 LGLTGVWLALPIGEVLRALLLL 425
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
70-412 |
1.54e-37 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 141.61 E-value: 1.54e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 70 PIALTALLLYSRTALSMLFLGSIGDLPLAAGSLAvAFANITGYSVLSGLSLGMDPLCSQAFGANQARLLGLTLYRSVLFL 149
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLG-SSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 150 LCCSLPLSALWLNMSKILVFLGQ-DREITALAQEYILFSLPDLFSFSIIHPLRVYLRSQGITRPLAAAAAAAVLFHVPAN 228
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGaDGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 229 YVLV-GRLG-LGAPGVAAAASASNFVLLGVLLAYVAGRRDAALLAAGPPTvEWLAGWGPLARLAAPSCVSVCLEWWWYEV 306
Cdd:TIGR00797 160 YILIfGKFGfLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLK-PDWEVLKRLLKLGLPIAFRVILESLSFAL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 307 MILLCGLLPDPkpAVASMGVLMQTTALVYVFPSSLGFGVSTRVGNELGANRPGRARAAAHVAVAGATGMGLAAMSFAAGV 386
Cdd:TIGR00797 239 LALLVARLGSI--ALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILF 316
|
330 340
....*....|....*....|....*.
gi 1981903693 387 RHAWGRMFTADADILRLTAAALPIVG 412
Cdd:TIGR00797 317 REFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
70-230 |
2.44e-29 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 113.43 E-value: 2.44e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 70 PIALTALLLYSRTALSMLFLGSIGDLPLAAGSLAVAFANITgYSVLSGLSLGMDPLCSQAFGANQARLLGLTLYRSVLFL 149
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLI-FMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 150 LCCSLPLSAL-WLNMSKILVFLGQDREITALAQEYILFSLPDLFSFSIIHPLRVYLRSQGITRPLAAAAAAAVLFHVPAN 228
Cdd:pfam01554 80 LLLSLPIALLvLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 1981903693 229 YV 230
Cdd:pfam01554 160 YL 161
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
63-491 |
1.85e-28 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 118.00 E-value: 1.85e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 63 ALCRLAFPIALTALLLYSRTALSMLFLGSIGDLPLAAGSLAVAFANITgYSVLSGLSLGMDPLCSQAFGANQARLLGLTL 142
Cdd:cd13137 2 RIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLL-LVLNMALGTGTVALVSQSYGAGDYERARRAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 143 YRSVLFLLCCSLPLSALWLNMSK-ILVFLGQDREITALAQEY---ILFSLPDLFSFSIIHPLrvyLRSQGITR-PLAAAA 217
Cdd:cd13137 81 GQSLLLALLLSLPLALLGLLFAEpLLRLLGADPEVIALALTYlriVLLGIPFFFLSLVGNAA---LRGAGDTKtPMYIMI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 218 AAAVLfHVPANYVLV----GRLGLGAPGVAAAASASNFVLLGVLLAYVAGRRDAALLAAGPPTVEWLAGWgPLARLAAPS 293
Cdd:cd13137 158 IVNVL-NIVLDYVLIfglwGFPGLGVAGAALATVISRVVGALLLLFLLLRGRLPIKISFKGFRLDRKIIK-KLLRIGLPA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 294 CVSVCLewWWYEVMILLCGLLPDPKPAVASMGVLMQTTALVYVFPSSLGFGVSTRVGNELGANRPgrarAAAHVAVAGAT 373
Cdd:cd13137 236 GLEQLL--RSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDP----DEARRYGKRAL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 374 GMGLAAMSFAAGV----RHAWGRMFTADADILRLTAAALPIVGLCELGNCPQTVGCGVLRGSARPTRAAHVNLGAFYLVG 449
Cdd:cd13137 310 RLGVLFMGLLGLLlfifAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVR 389
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 1981903693 450 MPVAVLLAFGLGVGFVGLWMGLLAAQVCCAGLMLCVVGSTDW 491
Cdd:cd13137 390 LPLAYLLGFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKW 431
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
292-455 |
1.07e-23 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 97.64 E-value: 1.07e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 292 PSCVSVCLEWWWYEVMILLCGLLPDPkpAVASMGVLMQTTALVYVFPSSLGFGVSTRVGNELGANRPGRARAAAHVAVAG 371
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAV--ALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLIL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 372 ATGMGLAAMSFAAGVRHAWGRMFTADADILRLTAAALPIVGLCELGNCPQTVGCGVLRGSARPTRAAHVNLGAfYLVGMP 451
Cdd:pfam01554 79 GLLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIP 157
|
....
gi 1981903693 452 VAVL 455
Cdd:pfam01554 158 LNYL 161
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
66-473 |
1.02e-22 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 101.04 E-value: 1.02e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 66 RLAFPIALTALLLYSRTALSMLFLGSIGDLPLAAGSLAVAFANItGYSVLSGLSLGMDPLCSQAFGANQARLLGLTLYRS 145
Cdd:cd13134 7 ALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFL-LILIFSFISTGTSILIAQYLGAKDKKKARQIAGVA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 146 VLFLLCCSLPLSALWLNMSK-ILVFLGQDREITALAQEYILFSLPDLFSFSIIHPLRVYLRSQGITRPLAAAAAAAVLFH 224
Cdd:cd13134 86 LLFNLLLGLVFSLLLLFFGAeLLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNILN 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 225 VPANYVLV----GRLGLGAPGVAAAASASNFVLLGVLLAYVAGRRDAALLAAGPPTVEWLAgWGPLARLAAPScvsvCLE 300
Cdd:cd13134 166 IVGNYLLIfgwfGLPKLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFRLKDLRPFPKKL-LKKILKIGLPS----AGE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 301 W--WWYEVMILL-----CGLLpdpkpAVASMGVLMQTTALVYVFPSSLGFGVSTRVGNELGANRPGRARAAAHVAVAGAT 373
Cdd:cd13134 241 ElsYNLSQTVITafiarLGTA-----ALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 374 GMGLAAMSFAAGVRHAWGRMFTADADILRLTAAALPIVGLCELGNCPQTVGCGVLRGSARPTRAAHVNLGAFYLVGMPVA 453
Cdd:cd13134 316 LVSLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGISVPLA 395
|
410 420
....*....|....*....|
gi 1981903693 454 VLLAFGLGVGFVGLWMGLLA 473
Cdd:cd13134 396 YLLGIVLGLGLLGVWIAFAA 415
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
68-483 |
4.97e-22 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 98.55 E-value: 4.97e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 68 AFPIALTALLLYSRTALSMLFLGSIGDLPLAAGSLAVAFANITgYSVLSGLSLGMDPLCSQAFGANQARLLGLTLYRSVL 147
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALL-IALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 148 FLLCCSLPLSALWLNMSK-ILVFLGQDREITALAQEYILFSLPDLFSFSIIHPLRVYLRSQGITRPLAAAAAAAVLFHVP 226
Cdd:cd12082 80 LAILLGLLLAALLLFFSPlILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 227 ANYVLV---GRLGLGAPGVAAAASASNFVLLGVLLAYVAGRRDAALLAAGPPTVEWlAGWGPLARLAAPSCVSVCLEWWW 303
Cdd:cd12082 160 LDPLLIfglGPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDL-ELLRRLLRIGLPSAIQNSLLSLG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 304 YEVMILLCGLLPDPkPAVASMGVLMQTTALVYVFPSSLGFGVSTRVGNELGANRPGRARAAAHVAVAGATGMGLAAMSFA 383
Cdd:cd12082 239 LLIIVAIVAAFGGA-AALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLI 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 384 AGVRHAWGRMFTADADILRLTAAALPIVGLCELGNCPQTVGCGVLRGSARPTRAAHVNLGAFYLVGMPVAVLLAFgLGVG 463
Cdd:cd12082 318 LLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAY-LGLG 396
|
410 420
....*....|....*....|
gi 1981903693 464 FVGLWMGLLAAQVCCAGLML 483
Cdd:cd12082 397 LYGIWLALVISLILAALVLL 416
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
60-483 |
5.78e-20 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 92.57 E-value: 5.78e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 60 EAAALCRLAFPIALTALLLYSRTALSMLFLGSIGDLPLAAGSLAVAFAnITGYSVLSGLSLGMDPLCSQAFGANQARLLG 139
Cdd:PRK01766 10 EARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSIW-LPVILFGHGLLLALTPIVAQLNGAGRRERIA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 140 LTLYRSVLFLLCCSLPLSA-LWLNMSKILVFLGQDREITALAQEY---ILFSLPDLFSFSIihpLRVYLRSQGITRPLAA 215
Cdd:PRK01766 89 HQVRQGLWLALFLSVLIMLvLYNAVPPILNMMNLEPEVADIAVGYlhaLLWGIPAYLLYQV---LRSFIDGLGKTKPTMV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 216 AAAAAVLFHVPANYVLV-GRLG---LGAPGVAAAASASNFVLLGVLLAYVA-GRRDAAL-LAAGPPTVEWLAgWGPLARL 289
Cdd:PRK01766 166 IGFLGLLINIPLNYIFIyGKFGfpeLGGVGCGVATAIVYWVMFLAMLIYIKrARRFRDFrLFKGLYKPDWAV-IKRLLKL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 290 AAPSCVSVCLEWWWYEVMILLCGLLPDPkpAVASMGVLMQTTALVYVFPSSLGFGVSTRVGNELGANRPGRARAAAHVAV 369
Cdd:PRK01766 245 GLPIGLAIFFEVSLFAVVTLLVSPLGTV--TVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAYIGL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 370 AGATGMGLAAMSFAAGVRHAWGRMFTADADILRLTAAALPIVGLCELGNCPQTVGCGVLRGsARPTRAA-HVNLGAFYLV 448
Cdd:PRK01766 323 AVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRG-YKDTRVIfFITFIAYWVL 401
|
410 420 430
....*....|....*....|....*....|....*
gi 1981903693 449 GMPVAVLLAFGLGVGFVGLWMGLLAAQVCCAGLML 483
Cdd:PRK01766 402 GLPLGYILALTDPMGPFGFWIGLIIGLTAAAILLL 436
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
64-485 |
2.15e-19 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 90.66 E-value: 2.15e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 64 LCRLAFPIALTALllySRTALSM---LFLGSIGDLPLAAgSLAVAFANITGYSVLSGLSLGMDPLCSQAFGANQARLLGL 140
Cdd:cd13133 7 ILKIALPLVLSML---SQTVMGFtdrAFLGRLSEVALAA-SGPAGVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 141 TLYRSVLFLLCCSLPLSAL-WLNMSKILVFLGQDREITALAQEY----ILFSLPDLFSFSiihpLRVYLRSQGITRPLAA 215
Cdd:cd13133 83 VLWQGLYFSLLLAPLLALLsALAAPLLFLLLGHSPEVQALEVEYfrirILGAPFSLLGAA----LRAFFSGIGRTRVVMV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 216 AAAAAVLFHVPANYVLV-GRLG---LGAPGVAAAASASNFVLLGVLLAYVAGRRDAALLAagpptveWLAGWGP------ 285
Cdd:cd13133 159 ANLVMVVVNIVLDYALIfGKLGfpaMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRRFG-------LRRAWRFdrellr 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 286 -LARLAAPSCVSVCLEWWWYEVMILLCGLLPdpKPAVASMGVLMQTTALVYVFPSSLGFGVSTRVGNELGANRPGRARAA 364
Cdd:cd13133 232 rILRLGLPSGLQFFLDVGAFTVFFLLIGRLG--TTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRV 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 365 AHVAVAGATGMGLAAMSFAAGVRHAWGRMFTADAD---ILRLTAAALPIVGLCELGNCPQTVGCGVLRGSARPTRAAHVN 441
Cdd:cd13133 310 TRRGLKLALAYMLLLGILFLLFPELLLSIFTPGADfalIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAE 389
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 1981903693 442 LGAFYLVGMPVAVLLAFgLGVGFVGLWMGLLaAQVCCAGLMLCV 485
Cdd:cd13133 390 LIVAWLYLLPPAYLLVV-LGAGLAGAWTVET-VYVIVLALIFLL 431
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
63-492 |
1.26e-14 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 75.96 E-value: 1.26e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 63 ALCRLAFPIALTALL--LYSrtALSMLFLGSI-GDLPLAAGSLAVAFANITgYSVLSGLSLGMDPLCSQAFGANQARLLG 139
Cdd:cd13138 4 TLLLFALPLLLSNLLqqLYN--LVDLLIVGQFlGVAALAAVSNGSPIIFLL-TAIGMGLSMGGTILISQYIGAKDEEKAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 140 LTLYRSVLFLLCCSLPLSAL-WLNMSKILVFLGQDREITALAQEYI---LFSLPDLFSFSIIhplRVYLRSQGITR-PLA 214
Cdd:cd13138 81 KAVGTLLVLFLILGIVLTILgLLFAPPILRLMNTPAEILELAVSYLricFLGIPFIFGYNAY---SAILRGLGDSKtPLY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 215 AAAAAAVLfHVPANYVLVGRLGLGAPGVAAAASASNFVLLGVLLAYVAGRRDAALLAAGPPTVEWLAGWgPLARLAAPSC 294
Cdd:cd13138 158 FVIIACVL-NIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRKKKLPFKLSLKDFRFDKEILK-EILKIGLPSA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 295 VS---VCLEWWWYEVMILLCGLLpdpkpAVASMGVLMQTTALVYVFPSSLGFGVSTRVGNELGANRPGRARAAAHVAVAG 371
Cdd:cd13138 236 LQqslVSISFLIINSIVNSYGVV-----ASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIII 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 372 ATGMGLAAMSFAAGVRHAWGRMFTADADILRLTAAALPIVGLCELGNCPQTVGCGVLRGSARPTRAAHVNLGAFYLVGMP 451
Cdd:cd13138 311 SLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIP 390
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 1981903693 452 VAVLLAFGLGVGFVGLWMGLLAAQVCCAGLMLCVVGSTDWE 492
Cdd:cd13138 391 LAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKGRWK 431
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
66-481 |
6.78e-13 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 70.62 E-value: 6.78e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 66 RLAFPIALTALLLYSRTALSMLFLG-SIGDLPLAAGSLAVAFAN-ITGYSVLsgLSLGMDPLCSQAFGANQARLLGLTLY 143
Cdd:cd13143 8 KFALPAIIGMLVNGLYNIVDGIFVGhGVGALALAAVNLVFPIIMlLMALGLM--IGVGGASLISRRLGAGDREKANRIFS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 144 RSVLFLLCCSLPLSAL-WLNMSKILVFLGQDREITALAQEY---ILFSLPDLFSFSIIHPLrvyLRSQGITRPLAAAAAA 219
Cdd:cd13143 86 TALLLSLILGLLLTILgLLFLDPLLRLLGASGELLPYAVDYlriILLGAPFTILSSVLNNL---LRAEGKPKLAMLGMLI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 220 AVLFHVPANYVLVGRLGLGAPGVAAAASASNFVLLGVLLAYVAGRRDAALLAAGPPTVEWlAGWGPLARLAAPSCV---S 296
Cdd:cd13143 163 GAVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLSLLRFKLSL-KIIKEILALGFPSFLmqlS 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 297 VCLewwwyeVMILLCGLL--PDPKPAVASMGVLMQTTALVYVFPSSLGFGVSTRVGNELGANRPGRARAAAHVAVAGATG 374
Cdd:cd13143 242 SSV------VTIVLNLTLlgYGGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALI 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 375 MGLAAMSFAAGVRHAWGRMFTADADILRLTAAALPIVGLCELGNCPQTVGCGVLRGSARPTRAAHVNLGAFYLVGMPVAV 454
Cdd:cd13143 316 YGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFLIPLLL 395
|
410 420
....*....|....*....|....*..
gi 1981903693 455 LLAFGLGVGfvGLWMGLLAAQVCCAGL 481
Cdd:cd13143 396 ILPRLFGLD--GIWLAFPLAEILTLLL 420
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
63-260 |
1.39e-12 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 69.79 E-value: 1.39e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 63 ALCRLAFPIALTALLLYSRTALSMLFLGSIGDLPLAAGSLAVAFANITgYSVLSGLSLGMDPLCSQAFGANQARLLGLTL 142
Cdd:COG0534 230 RILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLA-FMPALGLGQAAQPLVGQNLGAGDYDRARRAA 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 143 YRSVLFLLCCSLPLSAL-WLNMSKILVFLGQDREITALAQEYILFSLPDLFSFSIIHPLRVYLRSQGITR-PLAAAAAAA 220
Cdd:COG0534 309 RLALLLALGIGLLLALLlFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRfPMIISLLRL 388
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1981903693 221 VLFHVPANYVLvGRLGLGAPGVAAAASASNFVLLGVLLAY 260
Cdd:COG0534 389 WLVRLPLAYLL-AFLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
63-491 |
1.86e-10 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 62.98 E-value: 1.86e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 63 ALCRLAFPIALTALLLYSRTALSMLFLGSIGDLPLAAGSLA--VAFaniTGYSVLSGLSLGMDPLCSQAFGANQARLLGL 140
Cdd:cd13142 12 TLLKLAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSISwpLIF---LFISLGGGLTVAGTALVAQYTGAGDYDKANK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 141 TLYRSVLFLLCCSLPLSALWLNMSK--ILVFLGQDREITALAQEY---ILFSLPDLFSFSIihpLRVYLRSQGITR-PLA 214
Cdd:cd13142 89 VAGQTFSFVIILSLILAVLGYILSRplLLLLIGAPEEVYPLALAYlriIFLGLPFMFIFFV---FNSLLRGIGDTKtPMK 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 215 AaaaaaVLFHVPANYVLVGRLGLGAPGvaaaasasnFVLLGVL---LAYVAGRRDAALLA--------AGP--------P 275
Cdd:cd13142 166 I-----MFGSVLLNVILDPLLIFGIGP---------FPGLGVAgaaLATVISRGIAAVIGlyllfkgrVGLkislrdlkP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 276 TVEWLagwGPLARLAAPSCVSVCLEWWWYEVMILLCGLLPDPkpAVASMGVLMQTTALVYVFPSSLGFGVSTRVGNELGA 355
Cdd:cd13142 232 DWEWL---KKIFRIGLPSSIEQSARALGFTVMTALVAGFGTV--VVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGA 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 356 NRPGRARAAAHVAVAGATGMGLAAMSFAAGVRHAWGRMFTADADILRLTAAALPIVGLCELGNCPQTVGCGVLRGSARPT 435
Cdd:cd13142 307 GQIDRAEEIVKKAALLIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTL 386
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 1981903693 436 RAAHVNLGAFYLVGMPVAVLLAFGLGVGFVGLWMGLLAAQVCCAGLMLCVVGSTDW 491
Cdd:cd13142 387 TAMIISILRLWVIRIPLAYLLAYVLGLGVTGIWIAMAISNIVAALIALAWFKRGTW 442
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
60-479 |
5.80e-08 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 55.14 E-value: 5.80e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 60 EAAALCRLAFPIALTALLLYSRTALSMLFLGSIGDLPLAAGSLAVAfanitGYSVLS----GLSLGMDPLCSQAFGANQ- 134
Cdd:PRK00187 8 ELKAILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLGAA-----SYSFVSifcvGVIAAVGTLVAIRHGAGDi 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 135 ---ARLLGLTLYRSVLFLLCCSLplsALWlNMSKILVFLGQDREITALAQEYIL---FSLPDLFSFSIihpLRVYLRSQG 208
Cdd:PRK00187 83 egaTRLAQAGLWLAWLLALVAAL---LLW-NLKPLLLLFGQAPQNVDAAMQFLHllpFALPGYLSFMA---LRGFTSALG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 209 ITRPLAAAAAAAVLFHVPANYVLV-GRLGLGAPGVAAAASASNFVLLGVLLAyVAG--RRDAALLAAGPPTVEWLAGWGP 285
Cdd:PRK00187 156 RAGPVMVISLAGAVANLLLNYALIeGWFGLPKLGLMGIGLVTALVSNGMALA-LALyiRRHPAYAAYPLRKGLSRPSRAA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 286 LA---RLAAPSCVSVCLEWWWYEVMILLCGLLPDPkpAVASMGVLMQTTALVYVFPSSLGFGVSTRVGNELGANRpgraR 362
Cdd:PRK00187 235 LRelwRLGLPIGGTYAVEVGLFTFAALCMGALGST--QLAAHQIALQIVSVAFMVPVGLSYAVTMRVGQHYGAGR----L 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 363 AAAHVAVAGATGMGLAAMSFAAGV----RHAWGRMFT-----ADADILRLTAAALPIVGLCELGNCPQTVGCGVLRG--S 431
Cdd:PRK00187 309 LEARRAGRVGIGFGAVVMLLFAGLfwllPEAIIGLFLdrndpAFAEIVQLAVSLLAVAAWFELFDGTQTIAMGAIRGlkD 388
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 1981903693 432 ARPTRAahVNLGAFYLVGMPVAVLLAFGLGVGFVGLWMGLLAAQVCCA 479
Cdd:PRK00187 389 ARTTFL--IGLACYWLVGAPLAWLLAFTLGWGAVGVWWGLALGLACAA 434
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
63-194 |
4.14e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 42.90 E-value: 4.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 63 ALCRLAFPIALTALL--LYSRTAlsMLFLGSIGDLPLAA-GslAVAFANITGYSVLSGLSLGMDPLCSQAFGAN------ 133
Cdd:cd13140 6 TLLRLALPIMGTSFIqmAYNLTD--MFWVGRLGSDAVAAvG--TAGFFVWLAYALALLSKIGAQVKVSQSIGAKdekear 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1981903693 134 ----QARLLGLTLyrSVLFLLCcslplsaLWLNMSKILVFLG-QDREITALAQEYILFSLPDL-FSF 194
Cdd:cd13140 82 kyarNALQLNLLL--GILYGLL-------LLLFAKPLIGFFNlGDAEVISLAITYLRIVALGLiFSF 139
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
66-473 |
6.65e-04 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 42.16 E-value: 6.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 66 RLAFPIALTALL--LYSRTALSmlFLGSIGDL-PLAAGSLAVAFANITgYSVLSGLSLGMDPLCSQAFGANQARLLGLTL 142
Cdd:cd13136 7 ALALPAILSNITvpLLGLVDTA--VVGHLGSAaYLGAVALGTTIFNTL-FWLFGFLRMGTTGLVAQALGAGDREEAIALL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 143 YRSVLFLLCCSLPLSAL--WLnMSKILVFLGQDREITALAQEY---ILFSLP-DLFSFSIIHplrvYLRSQGITRPLAAA 216
Cdd:cd13136 84 VRALLLALAIGLLLILLqsPL-LALALLLLGASAAVAALARQYlriRILGAPaVLLNYVATG----WFRGLQDTRTPLIL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 217 AAAAVLFHVPANYVLVGRLGLGAPGVAAAASASNFVLLGVLLAYVAGRRDAALLAAGPPTVEWlAGWGPLARLAAP---- 292
Cdd:cd13136 159 QIVGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRRRVRLLGKSLSRRLPSK-AALKRLFKLNRDifir 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 293 -SCVSVCLEWwwyevMILLCGLLPDpkPAVASMGVLMQTTALVYVFPSSLGFGVSTRVGNELGANRPGRARAAAHVAVAG 371
Cdd:cd13136 238 tLALLAAFLF-----FTALAARLGD--VILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQW 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1981903693 372 ATGMGLAAMSFAAGVRHAWGRMFTADADILRLTAAALPIVGLCELGNCPQTVGCGVLRGS--ARPTRAAHVNLGAFYLVg 449
Cdd:cd13136 311 GLGLGVLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGAtdTRYLRNSMLVSLAVFLP- 389
|
410 420
....*....|....*....|....
gi 1981903693 450 mpvaVLLAFGLGVGFVGLWMGLLA 473
Cdd:cd13136 390 ----LLFLLVPLWGNHGLWLALIL 409
|
|
| |
