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Conserved domains on  [gi|1977118752|gb|KAG2458180|]
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TILB protein, partial [Polypterus senegalus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 68-191 8.33e-21

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 91.00  E-value: 8.33e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1977118752  68 EIEKIEYIDKwCKELKILYLQNNLIGKIENVGRLKKLEYLNLALNNIERVENLEGCESLQ-------------KLDF--- 131
Cdd:cd21340    35 KITKIENLEF-LTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlppgeKLTFdpr 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1977118752 132 --------------------TVNFIGELSSIESL---QNNI--------------HLQELYLVGNP-CTDFKgYREFVVA 173
Cdd:cd21340   114 slaalsnslrvlnisgnnidSLEPLAPLRNLEQLdasNNQIsdleelldllsswpSLRELDLTGNPvCKKPK-YRDKIIL 192

                         170
                  ....*....|....*...
gi 1977118752 174 TLHQLKSLDGKKIERSER 191
Cdd:cd21340   193 ASKSLEVLDGKEITDTER 210
PTZ00121 super family cl31754
MAEBL; Provisional
 187-315 1.39e-04

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.75  E-value: 1.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1977118752  187 ERSERIKATQDLPTIRQWIREQEEtyLKRRIQEKREAErNLEKKNRSKSKTQSEERGpviGQESNKEGKLPEKVQTEEEH 266
Cdd:PTZ00121  1425 KKAEEKKKADEAKKKAEEAKKADE--AKKKAEEAKKAE-EAKKKAEEAKKADEAKKK---AEEAKKADEAKKKAEEAKKK 1498

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1977118752  267 ISDTHEEESDKEFWEKPTQFTPESRIETHRHMEEKRKAKEAQRFEATKK 315
Cdd:PTZ00121  1499 ADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKK 1547
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 68-191 8.33e-21

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 91.00  E-value: 8.33e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1977118752  68 EIEKIEYIDKwCKELKILYLQNNLIGKIENVGRLKKLEYLNLALNNIERVENLEGCESLQ-------------KLDF--- 131
Cdd:cd21340    35 KITKIENLEF-LTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlppgeKLTFdpr 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1977118752 132 --------------------TVNFIGELSSIESL---QNNI--------------HLQELYLVGNP-CTDFKgYREFVVA 173
Cdd:cd21340   114 slaalsnslrvlnisgnnidSLEPLAPLRNLEQLdasNNQIsdleelldllsswpSLRELDLTGNPvCKKPK-YRDKIIL 192

                         170
                  ....*....|....*...
gi 1977118752 174 TLHQLKSLDGKKIERSER 191
Cdd:cd21340   193 ASKSLEVLDGKEITDTER 210
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-165 6.76e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 6.76e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1977118752  79 CKELKILYLQNNLIGKI-ENVGRLKKLEYLNLALNNIERVENLEGCESLQKLDFTVNFIGELSSIESLQNnihLQELYLV 157
Cdd:COG4886   204 LTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTN---LKTLDLS 280


                  ....*...
gi 1977118752 158 GNPCTDFK 165
Cdd:COG4886   281 NNQLTDLK 288
LRR_9 pfam14580
Leucine-rich repeat;
87-196 4.22e-10

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 58.62  E-value: 4.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1977118752  87 LQNNLIGKIENVGRLKKLEYLNLALNNIERV-ENL-EGCESLQKLDFTVNFIGELSSIESLQNNIHLQELYLVGNPCTDF 164
Cdd:pfam14580  49 FSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLgEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNK 128

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1977118752 165 KGYREFVVATLHQLKSLDGKKIERSERIKATQ 196
Cdd:pfam14580 129 PHYRLYVIYKVPQLRLLDFRKVKQKERQAAEK 160
PTZ00121 PTZ00121
MAEBL; Provisional
 187-315 1.39e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.75  E-value: 1.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1977118752  187 ERSERIKATQDLPTIRQWIREQEEtyLKRRIQEKREAErNLEKKNRSKSKTQSEERGpviGQESNKEGKLPEKVQTEEEH 266
Cdd:PTZ00121  1425 KKAEEKKKADEAKKKAEEAKKADE--AKKKAEEAKKAE-EAKKKAEEAKKADEAKKK---AEEAKKADEAKKKAEEAKKK 1498

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1977118752  267 ISDTHEEESDKEFWEKPTQFTPESRIETHRHMEEKRKAKEAQRFEATKK 315
Cdd:PTZ00121  1499 ADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKK 1547
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 68-191 8.33e-21

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 91.00  E-value: 8.33e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1977118752  68 EIEKIEYIDKwCKELKILYLQNNLIGKIENVGRLKKLEYLNLALNNIERVENLEGCESLQ-------------KLDF--- 131
Cdd:cd21340    35 KITKIENLEF-LTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEelhienqrlppgeKLTFdpr 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1977118752 132 --------------------TVNFIGELSSIESL---QNNI--------------HLQELYLVGNP-CTDFKgYREFVVA 173
Cdd:cd21340   114 slaalsnslrvlnisgnnidSLEPLAPLRNLEQLdasNNQIsdleelldllsswpSLRELDLTGNPvCKKPK-YRDKIIL 192

                         170
                  ....*....|....*...
gi 1977118752 174 TLHQLKSLDGKKIERSER 191
Cdd:cd21340   193 ASKSLEVLDGKEITDTER 210
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-165 6.76e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 6.76e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1977118752  79 CKELKILYLQNNLIGKI-ENVGRLKKLEYLNLALNNIERVENLEGCESLQKLDFTVNFIGELSSIESLQNnihLQELYLV 157
Cdd:COG4886   204 LTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTN---LKTLDLS 280


                  ....*...
gi 1977118752 158 GNPCTDFK 165
Cdd:COG4886   281 NNQLTDLK 288
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-182 7.13e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.27  E-value: 7.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1977118752  79 CKELKILYLQNNLIGKI-ENVGRLKKLEYLNLALNNIERV-ENLEGCESLQKLDFTVNFIGELSsiESLQNNIHLQELYL 156
Cdd:COG4886   135 LTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLP--EPLGNLTNLEELDL 212

                          90       100
                  ....*....|....*....|....*.
gi 1977118752 157 VGNPCTDFkgyrEFVVATLHQLKSLD 182
Cdd:COG4886   213 SGNQLTDL----PEPLANLTNLETLD 234
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-182 3.12e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.26  E-value: 3.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1977118752  79 CKELKILYLQNNLIGKI-ENVGRLKKLEYLNLALNNIERV-ENLEGCESLQKLDFTVNFIGELSsiESLQNNIHLQELYL 156
Cdd:COG4886   112 LTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLP--EELGNLTNLKELDL 189

                          90       100
                  ....*....|....*....|....*.
gi 1977118752 157 VGNPCTDFKGyrefVVATLHQLKSLD 182
Cdd:COG4886   190 SNNQITDLPE----PLGNLTNLEELD 211
LRR_9 pfam14580
Leucine-rich repeat;
87-196 4.22e-10

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 58.62  E-value: 4.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1977118752  87 LQNNLIGKIENVGRLKKLEYLNLALNNIERV-ENL-EGCESLQKLDFTVNFIGELSSIESLQNNIHLQELYLVGNPCTDF 164
Cdd:pfam14580  49 FSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLgEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSLLRNPVTNK 128

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1977118752 165 KGYREFVVATLHQLKSLDGKKIERSERIKATQ 196
Cdd:pfam14580 129 PHYRLYVIYKVPQLRLLDFRKVKQKERQAAEK 160
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-196 2.43e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.10  E-value: 2.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1977118752  79 CKELKILYLQNNLIGKIENVGRLKKLEYLNLALNNIERVENLEGCESLQKLDFTVNFIGELsSIESLQNNIHLQELYLVG 158
Cdd:COG4886   227 LTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL-KLKELELLLGLNSLLLLL 305

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1977118752 159 NPCTDFKGYREFVVATLHQLKSLDGKKIERSERIKATQ 196
Cdd:COG4886   306 LLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALS 343
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 85-159 9.55e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.87  E-value: 9.55e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1977118752  85 LYLQNNLIGKIENVGRLKKLEYLNLALNNIERVENLEGCESLQKLDFTVNFIgelSSIESLQNNIHLQELYLVGN 159
Cdd:cd21340     7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQI---EKIENLENLVNLKKLYLGGN 78
LRR_8 pfam13855
Leucine rich repeat;
81-130 5.22e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 5.22e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1977118752  81 ELKILYLQNNLIGKIENV--GRLKKLEYLNLALNNIERVEN--LEGCESLQKLD 130
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGafKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLD 55
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 80-122 2.12e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.46  E-value: 2.12e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1977118752  80 KELKILYLQNNLIGKIENVGRLKKLEYLNLALNN-IERVENLEG 122
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLAN 44
PTZ00121 PTZ00121
MAEBL; Provisional
 187-315 1.39e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.75  E-value: 1.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1977118752  187 ERSERIKATQDLPTIRQWIREQEEtyLKRRIQEKREAErNLEKKNRSKSKTQSEERGpviGQESNKEGKLPEKVQTEEEH 266
Cdd:PTZ00121  1425 KKAEEKKKADEAKKKAEEAKKADE--AKKKAEEAKKAE-EAKKKAEEAKKADEAKKK---AEEAKKADEAKKKAEEAKKK 1498

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1977118752  267 ISDTHEEESDKEFWEKPTQFTPESRIETHRHMEEKRKAKEAQRFEATKK 315
Cdd:PTZ00121  1499 ADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKK 1547
PTZ00121 PTZ00121
MAEBL; Provisional
 179-316 4.67e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 4.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1977118752  179 KSLDGKKIERSERIKATQdlptirqwIREQEETYLKRRIQEKREAERNLEKKNRSKSKTQSEERGPVIGQESNKEGKLPE 258
Cdd:PTZ00121  1634 KVEQLKKKEAEEKKKAEE--------LKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAE 1705

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1977118752  259 KVQTEEEhisdthEEESDKEFWEKPTQFTPESRIETHRHMEE-KRKAKEAQRFEATKKK 316
Cdd:PTZ00121  1706 ELKKKEA------EEKKKAEELKKAEEENKIKAEEAKKEAEEdKKKAEEAKKDEEEKKK 1758
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 102-147 5.44e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.61  E-value: 5.44e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1977118752 102 KKLEYLNLALNNIERVENLEGCESLQKLDFTVNFIgeLSSIESLQN 147
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNK--ITDLSDLAN 44
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 101-159 1.44e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 1.44e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1977118752 101 LKKLEYLNLALNNIERVENLEGCESLQKLDFTVNFIgelSSIESLQNNIHLQELYLVGN 159
Cdd:cd21340     1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKI---TKIENLEFLTNLTHLYLQNN 56
PTZ00121 PTZ00121
MAEBL; Provisional
 177-317 1.64e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.28  E-value: 1.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1977118752  177 QLKSLDGKKIERSERIKATQDLPTIRQWIREQEETYLKRRIQEKREAERNLEKKNRSKSKTQS-----EERGPV--IGQE 249
Cdd:PTZ00121  1562 EKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEElkkaeEEKKKVeqLKKK 1641

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1977118752  250 SNKEGKLPEKVQTEEEHISDTHEEESDKEFWEKPTQFTPESRIETHRHMEE--KRKAKEAQRFEATKKKK 317
Cdd:PTZ00121  1642 EAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEalKKEAEEAKKAEELKKKE 1711
PTZ00121 PTZ00121
MAEBL; Provisional
 179-316 1.85e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.28  E-value: 1.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1977118752  179 KSLDGKKIERSERIKATQDLPTIRQwIREQEETYLKRRIQEKREAErnlEKKNRSKSKTQSEERGPVIGQESNKEGKLPE 258
Cdd:PTZ00121  1105 KTETGKAEEARKAEEAKKKAEDARK-AEEARKAEDARKAEEARKAE---DAKRVEIARKAEDARKAEEARKAEDAKKAEA 1180

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1977118752  259 KVQTEEEHISDTHEEESDKEFWEKPTQFTPESRIETHRHMEEKRKAKEAQRFEATKKK 316
Cdd:PTZ00121  1181 ARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKD 1238
PTZ00121 PTZ00121
MAEBL; Provisional
 185-317 2.78e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.51  E-value: 2.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1977118752  185 KIERSERIKATQdlptirqwIREQEETYLKRRIQEKREAErnlEKKNRSKSKTQSEERGPVIGQESNK---EGKLPEKVQ 261
Cdd:PTZ00121  1613 KKAEEAKIKAEE--------LKKAEEEKKKVEQLKKKEAE---EKKKAEELKKAEEENKIKAAEEAKKaeeDKKKAEEAK 1681

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1977118752  262 TEEEHISDTHEEESDKEFWEKPTQFTPESRIETHRHMEEKRKAKEAQRFEATKKKK 317
Cdd:PTZ00121  1682 KAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKK 1737
PTZ00121 PTZ00121
MAEBL; Provisional
 185-317 4.23e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.12  E-value: 4.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1977118752  185 KIERSERIKATQDLPTIRQWIREQEETYLK-------RRIQEKREAERNLEKKNRSKSKTQS---EERGPVIGQESNKEg 254
Cdd:PTZ00121  1550 ELKKAEELKKAEEKKKAEEAKKAEEDKNMAlrkaeeaKKAEEARIEEVMKLYEEEKKMKAEEakkAEEAKIKAEELKKA- 1628

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1977118752  255 klpEKVQTEEEHISDTHEEESDK--EFWEKPTQFTPESRIETHRHMEEKRKAKEAQRFEATKKKK 317
Cdd:PTZ00121  1629 ---EEEKKKVEQLKKKEAEEKKKaeELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKA 1690
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 82-163 8.25e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 38.62  E-value: 8.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1977118752  82 LKILYLQNNLIGK------IENVGRLKKLEYLNLALNNI------ERVENLEGCESLQKLDFTVNFIGELSSI---ESLQ 146
Cdd:COG5238   210 VTTLWLKRNPIGDegaeilAEALKGNKSLTTLDLSNNQIgdegviALAEALKNNTTVETLYLSGNQIGAEGAIalaKALQ 289

                          90
                  ....*....|....*..
gi 1977118752 147 NNIHLQELYLVGNPCTD 163
Cdd:COG5238   290 GNTTLTSLDLSVNRIGD 306
PTZ00121 PTZ00121
MAEBL; Provisional
 179-316 8.88e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.97  E-value: 8.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1977118752  179 KSLDGKKIERSERIKATQDLPTIRQWIREQEETYLKRRIQEKREAERNLEKKNRSKSKTQSEERGPVIGQESNKEGKLPE 258
Cdd:PTZ00121  1315 KKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKAD 1394

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1977118752  259 KVQTEEEHISDTHEEESDKEFWEKPTQFTPESRIETHRHMEEKRKAKEAQRFEATKKK 316
Cdd:PTZ00121  1395 EAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKK 1452
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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