F-box domain found in Arabidopsis thaliana F-box/LRR-repeat protein 13 (AtARP13), 25 (AtARP25) and similar proteins; AtARP13 and AtARP25 belong to the largest subfamily of plant F-box proteins, F-box/LRR-repeat protein (FBLs). It contains tandem leucine-rich repeats (LRRs). Like other F-box proteins, they may be components of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

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                  ....*....|....*....|....*....|....*..
gi 1967406881   4 ISHLPEHLLLKILSFLPTtKDVVATMVLSKRWQFLWT 40
Cdd:cd22160     1 ISDLPDELLCHILSFLPT-KDAVKTSVLSKRWRHLWR 36

FBD; This region is found in F-box (pfam00646) and other domain containing plant proteins; it is repeated in two family members. Its precise function is unknown, but it is thought to be associated with nuclear processes. In fact, several family members are annotated as being similar to transcription factors.

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                  ....*....|....*....|....*....|....*....|....*
gi 1967406881 346 PSLVPECLLSSLETLEWTNYEGTKEEKEVVEFILRNGRCLKKVTI 390
Cdd:pfam08387   1 PSSVPECLLSSLETVEWRGYRGEEEEKEFAKYILENARVLKKATI 45

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1967406881   4 ISHLPEHLLLKILSFLPtTKDVVATMVLSKRWQFLWTLVPRIVY 47
Cdd:pfam00646   1 LLDLPDDLLLEILSRLD-PKDLLRLSLVSKRWRSLVDSLKLWKK 43

FBD; This region is found in F-box (pfam00646) and other domain containing plant proteins; it is repeated in two family members. Its precise function is unknown, but it is thought to be associated with nuclear processes. In fact, several family members are annotated as being similar to transcription factors.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1967406881 346 PSLVPECLLSSLETLEWTNYEGTKEEKEVVEFILRNGRCLKKVTI 390
Cdd:pfam08387   1 PSSVPECLLSSLETVEWRGYRGEEEEKEFAKYILENARVLKKATI 45

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1967406881   4 ISHLPEHLLLKILSFLPtTKDVVATMVLSKRWQFLWTLVPRIVY 47
Cdd:pfam00646   1 LLDLPDDLLLEILSRLD-PKDLLRLSLVSKRWRSLVDSLKLWKK 43

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

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                  ....*....|....*....|....*....|....*....|....*....
gi 1967406881   4 ISHLPEHLLLKILSFLPtTKDVVATMVLSKRWQflwtlvpRIVYDEDNW 52
Cdd:cd22123     1 LDQLPENVLLEILSYLP-VRDLLRISRVCKRWR-------RLVYDKTLW 41

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.

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                  ....*....|....*....|....*....|....
gi 1967406881   5 SHLPEHLLLKILSFLPtTKDVVATMVLSKRWQFL 38
Cdd:cd09917     1 SDLPDEILLKILSYLD-PRDLLRLSLVCKRWREL 33