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Conserved domains on  [gi|1940526634|gb|KAF9892632|]
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hypothetical protein FE257_001034 [Aspergillus nanangensis]

Protein Classification

MFS transporter( domain architecture ID 13023297)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 76-512 2.07e-129

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 381.92  E-value: 2.07e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  76 TCVVSMLNVVTCLCAGSISSGATQIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLP 155
Cdd:cd17323     1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 156 IALAQNIGTILVCRLIGGFAGGAPLTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGFRWIFWILM 235
Cdd:cd17323    81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 236 AITGAFWILIIVTVPetrhsiilqrktkrvrkqmqkenlksaesahdvnsahrkglhqlfaitltrpfrflisepITLFS 315
Cdd:cd17323   161 IISGFCLILIFLFLP------------------------------------------------------------IVLLL 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 316 AIYNGFLYGLVYLFNEAFPLVFGpgKGHGFNGGATGLTFLGLAIGPLVAFCFYPLQERYYLRR-VKENNGKGVPEARMWM 394
Cdd:cd17323   181 GLYVGLVYAILYLFLTAFPYVFG--EVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRlKKKNGGKPEPEARLPP 258

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 395 ARGGAFLIPISLFWFGWTSYRSVHWIVPIIASAFFGAGIYIVILSILNYVVDSYQTYSASALAGVILVRNLVGAGFPLFA 474
Cdd:cd17323   259 AFIGAFLFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFA 338

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1940526634 475 TQMYERLGYEWASSLLGFLAILLVPIPFIFFYMGRAIR 512
Cdd:cd17323   339 QPMFNNLGVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 76-512 2.07e-129

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 381.92  E-value: 2.07e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  76 TCVVSMLNVVTCLCAGSISSGATQIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLP 155
Cdd:cd17323     1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 156 IALAQNIGTILVCRLIGGFAGGAPLTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGFRWIFWILM 235
Cdd:cd17323    81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 236 AITGAFWILIIVTVPetrhsiilqrktkrvrkqmqkenlksaesahdvnsahrkglhqlfaitltrpfrflisepITLFS 315
Cdd:cd17323   161 IISGFCLILIFLFLP------------------------------------------------------------IVLLL 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 316 AIYNGFLYGLVYLFNEAFPLVFGpgKGHGFNGGATGLTFLGLAIGPLVAFCFYPLQERYYLRR-VKENNGKGVPEARMWM 394
Cdd:cd17323   181 GLYVGLVYAILYLFLTAFPYVFG--EVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRlKKKNGGKPEPEARLPP 258

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 395 ARGGAFLIPISLFWFGWTSYRSVHWIVPIIASAFFGAGIYIVILSILNYVVDSYQTYSASALAGVILVRNLVGAGFPLFA 474
Cdd:cd17323   259 AFIGAFLFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFA 338

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1940526634 475 TQMYERLGYEWASSLLGFLAILLVPIPFIFFYMGRAIR 512
Cdd:cd17323   339 QPMFNNLGVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
2_A_01_02 TIGR00880
Multidrug resistance protein;
116-252 1.95e-28

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 110.05  E-value: 1.95e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 116 SMYILGFAIGPVLLAPLSEY----FGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAGGAPLTNTGGSISDLW 191
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLltdrFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1940526634 192 ARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGFRWIFWILMAITGAFWILIIVTVPET 252
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
68-468 9.89e-27

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 111.22  E-value: 9.89e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  68 PRWQKWYITCVVSMLNVVTCLCAGSISSGATQIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWF 147
Cdd:COG2814     4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 148 VLFIFQLPIALAQNIGTILVCRLIGGFAGGAPLTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGF 227
Cdd:COG2814    84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 228 RWIFWILMAITGAFWILIIVTVPETRHSIilqrktkrvrkqmqkenlksaesahdvnsahrkglhqlfAITLTRPFRFLI 307
Cdd:COG2814   164 RWVFLVNAVLALLALLLLLRLLPESRPAA---------------------------------------RARLRGSLRELL 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 308 SEPITLFSAIYNGFLYGLVYLFNEAFPLVFgpGKGHGFNGGATGLTFLGLAIGPLV-AFCFYPLQERYYLRRVkenngkg 386
Cdd:COG2814   205 RRPRLLLLLLLAFLLGFGFFALFTYLPLYL--QEVLGLSASAAGLLLALFGLGGVLgALLAGRLADRFGRRRL------- 275

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 387 vpearmwmARGGAFLIPISLFWFGWTSyrsvHWIVPIIASAFFGAGIYIVILSILNYVVDSY-QTYSASALAGVILVRNL 465
Cdd:COG2814   276 --------LLIGLLLLALGLLLLALAG----SLWLLLLALFLLGFGFGLLFPLLQALVAELApPEARGRASGLYNSAFFL 343


                  ...
gi 1940526634 466 VGA 468
Cdd:COG2814   344 GGP 346
MFS_1 pfam07690
Major Facilitator Superfamily;
100-471 4.35e-24

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 103.27  E-value: 4.35e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 100 IAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAGGAP 179
Cdd:pfam07690  23 LAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGAL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 180 LTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGFRWIFWILMAITGAFWILIIVTVPETRHSIILQ 259
Cdd:pfam07690 103 FPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKP 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 260 RKTKRVRkqmqkenlksaesahdvnsahrkglhqlfaitLTRPFRFLISEPITLFSAIYNGFLYGLVYLFNEAFPLVFGP 339
Cdd:pfam07690 183 AEEARLS--------------------------------LIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 340 GKGHGFNGGATGLTFLGLAIGPLVAfcfyplqeRYYLRRVKenngkgvPEARMWMARGGAFLIPISLFWFGWTSYRSVHW 419
Cdd:pfam07690 231 GLSALLAGLLLGLGGLLGAIGRLLL--------GRLSDRLG-------RRRRLLLALLLLILAALGLLLLSLTLSSLWLL 295

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1940526634 420 IVPIIasafFGAGIYIVILSILNYVVDSYQTYSASALAGVI-LVRNLVGAGFP 471
Cdd:pfam07690 296 LALLL----LGFGFGLVFPALNALVSDLAPKEERGTASGLYnTAGSLGGALGP 344
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
99-252 5.21e-21

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 94.98  E-value: 5.21e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  99 QIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAGGA 178
Cdd:PRK11102   16 VIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAA 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1940526634 179 PLTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGFRWIFWILMAITGAFWILIIVTVPET 252
Cdd:PRK11102   96 ASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPET 169
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 76-512 2.07e-129

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 381.92  E-value: 2.07e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  76 TCVVSMLNVVTCLCAGSISSGATQIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLP 155
Cdd:cd17323     1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 156 IALAQNIGTILVCRLIGGFAGGAPLTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGFRWIFWILM 235
Cdd:cd17323    81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 236 AITGAFWILIIVTVPetrhsiilqrktkrvrkqmqkenlksaesahdvnsahrkglhqlfaitltrpfrflisepITLFS 315
Cdd:cd17323   161 IISGFCLILIFLFLP------------------------------------------------------------IVLLL 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 316 AIYNGFLYGLVYLFNEAFPLVFGpgKGHGFNGGATGLTFLGLAIGPLVAFCFYPLQERYYLRR-VKENNGKGVPEARMWM 394
Cdd:cd17323   181 GLYVGLVYAILYLFLTAFPYVFG--EVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRlKKKNGGKPEPEARLPP 258

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 395 ARGGAFLIPISLFWFGWTSYRSVHWIVPIIASAFFGAGIYIVILSILNYVVDSYQTYSASALAGVILVRNLVGAGFPLFA 474
Cdd:cd17323   259 AFIGAFLFPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFA 338

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1940526634 475 TQMYERLGYEWASSLLGFLAILLVPIPFIFFYMGRAIR 512
Cdd:cd17323   339 QPMFNNLGVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
2_A_01_02 TIGR00880
Multidrug resistance protein;
116-252 1.95e-28

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 110.05  E-value: 1.95e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 116 SMYILGFAIGPVLLAPLSEY----FGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAGGAPLTNTGGSISDLW 191
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLltdrFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1940526634 192 ARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGFRWIFWILMAITGAFWILIIVTVPET 252
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
68-468 9.89e-27

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 111.22  E-value: 9.89e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  68 PRWQKWYITCVVSMLNVVTCLCAGSISSGATQIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWF 147
Cdd:COG2814     4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 148 VLFIFQLPIALAQNIGTILVCRLIGGFAGGAPLTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGF 227
Cdd:COG2814    84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 228 RWIFWILMAITGAFWILIIVTVPETRHSIilqrktkrvrkqmqkenlksaesahdvnsahrkglhqlfAITLTRPFRFLI 307
Cdd:COG2814   164 RWVFLVNAVLALLALLLLLRLLPESRPAA---------------------------------------RARLRGSLRELL 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 308 SEPITLFSAIYNGFLYGLVYLFNEAFPLVFgpGKGHGFNGGATGLTFLGLAIGPLV-AFCFYPLQERYYLRRVkenngkg 386
Cdd:COG2814   205 RRPRLLLLLLLAFLLGFGFFALFTYLPLYL--QEVLGLSASAAGLLLALFGLGGVLgALLAGRLADRFGRRRL------- 275

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 387 vpearmwmARGGAFLIPISLFWFGWTSyrsvHWIVPIIASAFFGAGIYIVILSILNYVVDSY-QTYSASALAGVILVRNL 465
Cdd:COG2814   276 --------LLIGLLLLALGLLLLALAG----SLWLLLLALFLLGFGFGLLFPLLQALVAELApPEARGRASGLYNSAFFL 343


                  ...
gi 1940526634 466 VGA 468
Cdd:COG2814   344 GGP 346
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 99-498 4.01e-25

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 106.89  E-value: 4.01e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  99 QIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAGGA 178
Cdd:cd17320    24 AIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAA 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 179 PLTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGFRWIFWILMAITGAFWILIIVTVPETRHsiil 258
Cdd:cd17320   104 GSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLP---- 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 259 qrktKRVRKQMQKENLKSaesahdvnsahrkglhqlfaitltrpFRFLISEPITLFSAIYNGFLYGLVYLFNEAFPLVFG 338
Cdd:cd17320   180 ----EEKRKPLLSSLLRA--------------------------YKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYI 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 339 pgKGHGFNGGATGLTFLGLAIGPLVA--FCfyplqeRYYLRRVKenngkgvPEARMWMARGGAFLIPISLFWFGWTSYRS 416
Cdd:cd17320   230 --EQLGLSPAQFGLLFALNAIALILGslLN------GRLVRRFG-------PRRLLRLGLLLLLAAALVLLLAALLGGLS 294

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 417 VHWIVPIIASAFFGAGIYIVILSILNYVVDSYQTYSASALAGVIlvRNLVGAGFPLFATQMYE--RLGYEWASSLLGFLA 494
Cdd:cd17320   295 LWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLGFL--QFLIGALAGALVGLLPNgtALPMGLLILVLGLLA 372


                  ....
gi 1940526634 495 ILLV 498
Cdd:cd17320   373 LLLL 376
MFS_1 pfam07690
Major Facilitator Superfamily;
100-471 4.35e-24

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 103.27  E-value: 4.35e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 100 IAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAGGAP 179
Cdd:pfam07690  23 LAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGAL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 180 LTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGFRWIFWILMAITGAFWILIIVTVPETRHSIILQ 259
Cdd:pfam07690 103 FPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKP 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 260 RKTKRVRkqmqkenlksaesahdvnsahrkglhqlfaitLTRPFRFLISEPITLFSAIYNGFLYGLVYLFNEAFPLVFGP 339
Cdd:pfam07690 183 AEEARLS--------------------------------LIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVL 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 340 GKGHGFNGGATGLTFLGLAIGPLVAfcfyplqeRYYLRRVKenngkgvPEARMWMARGGAFLIPISLFWFGWTSYRSVHW 419
Cdd:pfam07690 231 GLSALLAGLLLGLGGLLGAIGRLLL--------GRLSDRLG-------RRRRLLLALLLLILAALGLLLLSLTLSSLWLL 295

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1940526634 420 IVPIIasafFGAGIYIVILSILNYVVDSYQTYSASALAGVI-LVRNLVGAGFP 471
Cdd:pfam07690 296 LALLL----LGFGFGLVFPALNALVSDLAPKEERGTASGLYnTAGSLGGALGP 344
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 68-253 1.41e-21

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 94.88  E-value: 1.41e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  68 PRWQKWYITCVVSMLNVVTCLCAGSISSGATQIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWF 147
Cdd:COG0477     8 PTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 148 VLFIFQLPIALAQNIGTILVCRLIGGFAGGAPLTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGF 227
Cdd:COG0477    88 LFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGW 167

                         170       180
                  ....*....|....*....|....*.
gi 1940526634 228 RWIFWIlMAITGAFWILIIVTVPETR 253
Cdd:COG0477   168 RWIFLI-NAPLGLLALVLRLRLPESR 192
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
99-252 5.21e-21

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 94.98  E-value: 5.21e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  99 QIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAGGA 178
Cdd:PRK11102   16 VIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAA 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1940526634 179 PLTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGFRWIFWILMAITGAFWILIIVTVPET 252
Cdd:PRK11102   96 ASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPET 169
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 100-266 3.19e-19

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 89.75  E-value: 3.19e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 100 IAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAGGAP 179
Cdd:TIGR00710  31 IAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAG 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 180 LTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGFRWIFWILMAITGAFWILIIVTVPETRHSIILQ 259
Cdd:TIGR00710 111 SVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETLPYEARI 190


                  ....*..
gi 1940526634 260 RKTKRVR 266
Cdd:TIGR00710 191 QISTYFE 197
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 98-498 5.67e-19

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 88.76  E-value: 5.67e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  98 TQIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAGG 177
Cdd:cd17324    23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHG 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 178 APLTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGFRWIFWILMAITGAFWILIIVTVPETRHSII 257
Cdd:cd17324   103 GFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKP 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 258 LQRKTKRVRKQMQKenlksaesahdvnsahRKGLHQLFAITLtrpfrflisepiTLFSAIYNGFLYGLVYLFNEAfplvf 337
Cdd:cd17324   183 GSLGLLSSLLLLLR----------------NPRLRLAYLITF------------LLFGGFFALYTYLAPFLTDVP----- 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 338 gpgkghGFNGGATGLTFLGLAIGplvAFCFYPLQERYYLRRVKenngkgvpeaRMWMARGGAFLIPISLFWFGWTsyrsv 417
Cdd:cd17324   230 ------GFSSSAIIGLLLLFGVA---GVVGSPLAGRLADRGGR----------RALLIALLLLAAALLLLTLLGP----- 285

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 418 HWIVPIIASAFFGAGIYIVILSILNYVVDSYQTYSASALAGVILVRNLVGAGFPLFATQMYERLGYE---WASSLLGFLA 494
Cdd:cd17324   286 SPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAgvgWVGAALLLLA 365


                  ....
gi 1940526634 495 ILLV 498
Cdd:cd17324   366 LLLA 369
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 79-504 7.99e-18

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 85.17  E-value: 7.99e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  79 VSMLNVVTCLCAGSISSGATQIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIAL 158
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 159 AQNIGTILVCRLIGGFAGGAPLTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYI--GLDLGFRWIFWILMA 236
Cdd:cd06174    81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILasSLGFGWRAVFLIAAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 237 ITGAFWILIIVTVPETRHSIilQRKTKRVRKQMQKENLKSAesahdvnsAHRKGLHQLFAItltrpfrflisepITLFSA 316
Cdd:cd06174   161 LALLAAILLLLVVPDPPESA--RAKNEEASSKSVLKLLKRV--------LKNPGLWLLLLA-------------IFLVNL 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 317 IYNGFLYGLVYLFNEAFPLVFGPGKGHGFNGGATGLTFlGLAIGPLVAFCFyplqeryylrrvkenngkgvpeARMWMAR 396
Cdd:cd06174   218 AYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALG-SLLLGLLSDRLI----------------------GRKPLLL 274

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 397 GGAFLIPISLFWFGWTSYRSVHWIVPIIASAFFGaGIYIVILSILNYVVDSYQTYSASALAGVIlvRNLVGAGFPLFATQ 476
Cdd:cd06174   275 IGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLG-GLLPLSFALIAELFPPEIRGTAFGLLNTF--GFLGGAIGPLLAGF 351

                         410       420
                  ....*....|....*....|....*...
gi 1940526634 477 MYERlGYEWASSLLGFLAILLVPIPFIF 504
Cdd:cd06174   352 LLAA-TFGLTGAFLVLAVLLLLAAILLL 378
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
68-247 7.03e-16

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 79.14  E-value: 7.03e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  68 PRWQKWYITCVVSMLNVVTCLCAGSISSGATQIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWF 147
Cdd:COG2271     4 PSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 148 VLFIFQLPIALAQNIGTILVCRLIGGFAGGAPLTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGF 227
Cdd:COG2271    84 LWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163

                         170       180
                  ....*....|....*....|
gi 1940526634 228 RWIFWIlMAITGAFWILIIV 247
Cdd:COG2271   164 RAAFLI-LGLPGLLLALLRF 182
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 100-245 3.46e-14

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 74.13  E-value: 3.46e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 100 IAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAGGAP 179
Cdd:cd17321    22 IARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAI 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1940526634 180 LTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGFRWIFWILMAITGAFWILI 245
Cdd:cd17321   102 MPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLA 167
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 99-505 3.57e-14

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 74.15  E-value: 3.57e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  99 QIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAGGA 178
Cdd:cd17325    21 LYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAA 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 179 PLTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGFRWIFWILMAITGAFWILIIVTVPETRHSIIL 258
Cdd:cd17325   101 VWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNK 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 259 QRKTkrvrkqmqkenlksaesahdvnsahrkglhqlfAITLTRPFRFLISEPiTLFSAIYNGFLYGLVYLFNEAFPLVFG 338
Cdd:cd17325   181 RAVS---------------------------------AARLRSGLRLLLRDR-RLLALFLAIFVLAFAFGALEPFLPLYA 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 339 PGKGhGFNGGATGLTFLGLAIGPLVAFcfyPLQERYYLRRVkenngkgvpeaRMWMARGGAFLIPISLFWFGwtsYRSVH 418
Cdd:cd17325   227 AELG-GLSPAQIGLLFGAQGLASALSQ---PPAGKLSDRIG-----------RKPLILIGLLLSAVALLLLP---LATSF 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 419 WIVpIIASAFFGAGIYIVILSILNYVVDSYQTYSASALAGVI-LVRNLVGAGFPLFATQMYERLGYEWASSLLGFLAILL 497
Cdd:cd17325   289 WLL-LLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFnTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLA 367


                  ....*...
gi 1940526634 498 VPIPFIFF 505
Cdd:cd17325   368 AVLFLLLR 375
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 78-505 1.70e-13

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 71.83  E-value: 1.70e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  78 VVSMLNVVTCLCAGSISSGATQIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIA 157
Cdd:cd17474     3 AVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 158 LAQNIGTILVCRLIGGFAGGAPLTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGlDLGFRWIFWILMAI 237
Cdd:cd17474    83 LSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAAL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 238 TGAFWILIIVTVPETRHsiilqrktkrvrkqmqKENLKSAESAHDVNSAHRKGLHQLFAITltrpfrflisepitlfSAI 317
Cdd:cd17474   162 IPVAFLAILFLLPEPKE----------------KAKSSSATKLRDLKKALRGRGLLTFLVS----------------AFL 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 318 YNgFLYGLVYLFneaFPLVFGpgKGHGFNGGATGLTFLGLAIG-PLVAFCFYPLQERYYLRRvkenngkgvpearmWMAR 396
Cdd:cd17474   210 YF-FLYFAFLTY---LPFLLE--LLYGISPIIIGLLFAGWSVLlALGSLFVGRLLKKRFGAR--------------RILV 269

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 397 GGAFLIPISLFWFGWTsyRSVHWIVPIIASAFFGAGIYIVILS-ILNYVVDSYQTYSASALAGVilVRNLVGAGFPLFAT 475
Cdd:cd17474   270 IGLLLYALSLLLLGFV--PSLALLLIAIVLFGLGLGLNLPLLTtLVTELAPEEERGTASSLYNF--VRFLGQAVGPLLFG 345

                         410       420       430
                  ....*....|....*....|....*....|
gi 1940526634 476 QMYERLGYEWASSLLGflAILLVPIPFIFF 505
Cdd:cd17474   346 LLLEIFGLSAPFLVGA--AIALAAAVLLAL 373
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 99-250 3.61e-13

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 71.07  E-value: 3.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  99 QIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAGGA 178
Cdd:cd17503    21 TIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGV 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1940526634 179 --PLTNTggSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGFRWIFWILMAITgafwILIIVTVP 250
Cdd:cd17503   101 liPLAQT--ILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG----ILALLLAP 168
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
92-252 1.85e-11

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 65.67  E-value: 1.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  92 SISSGATQIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLI 171
Cdd:COG2223    23 LWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 172 GGFAGGAPLTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGFRWIFWILMAITGAFWILIIVTVPE 251
Cdd:COG2223   103 LGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRD 182


                  .
gi 1940526634 252 T 252
Cdd:COG2223   183 P 183
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 92-250 6.19e-11

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 64.13  E-value: 6.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  92 SISSGATQIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLI 171
Cdd:cd17319    21 NISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 172 GGfAGGAPLTNTGGSISDLW-ARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGFRWIFWILMAITGAFWILIIVTVP 250
Cdd:cd17319   101 LG-VAEAGFFPGAIKALAEWfPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLR 179
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 99-245 1.33e-10

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 62.98  E-value: 1.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  99 QIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAGGA 178
Cdd:cd17504    21 TIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAV 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 179 -PLTNtgGSISDLWARNESGGAMAVygLSSTF--GPPIALVFSGYIGLDLGFRWIFWILMAITGAFWILI 245
Cdd:cd17504   101 fPLAF--ALVREEFPPERVPVAQGI--LSATFgiGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALV 166
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 79-246 5.93e-10

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 61.09  E-value: 5.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  79 VSMLNVVTCLCAGSISSGATQIAEE-FHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIA 157
Cdd:cd06173   213 LLLALALFALLGGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLG 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 158 LAQNIGTILVCRLIGGFAGGAPLTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGFRWIFWILMAI 237
Cdd:cd06173   293 LSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGAL 372

                         170
                  ....*....|.
gi 1940526634 238 T--GAFWILII 246
Cdd:cd06173   373 LllAALLLLLL 383
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 100-233 1.06e-09

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 59.88  E-value: 1.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 100 IAEEFHVSSEVTTLcLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAGGAP 179
Cdd:cd17502    22 IVAEFGGLSLVSWV-GTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGL 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1940526634 180 LTNTGGSISDLWARNE----SGGAMAVYGLSSTFGPPIALVFSGYigldLGFRWIFWI 233
Cdd:cd17502   101 MSLAFIIIADLVPPRErgkyQGYIGAVFGIASVAGPLIGGAFTDH----LSWRWCFYI 154
Sugar_tr pfam00083
Sugar (and other) transporter;
107-273 3.19e-09

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 59.21  E-value: 3.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 107 SSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALA---QNIGTILVCRLIGGFAGGAPLTNT 183
Cdd:pfam00083  44 LSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGASVLA 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 184 GGSISDLWARNESGGAMAVYGLSSTFGPPIALVF---SGYIGLDLGFRWIFWILMAITGAFwILIIVTVPETRHSIILQR 260
Cdd:pfam00083 124 PMYISEIAPKKLRGALGSLYQLAITFGILLAYIFglgLNKTSNSDGWRIPLGLQLVPALLL-IIGLLFLPESPRWLVEKG 202

                         170
                  ....*....|...
gi 1940526634 261 KTKRVRKQMQKEN 273
Cdd:pfam00083 203 RLEEAREVLAKLR 215
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
98-253 7.15e-09

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 57.57  E-value: 7.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  98 TQIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQ--PVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFA 175
Cdd:COG2271   205 TYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFG 284

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1940526634 176 GGAPLTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGFRWIFWILMAITGAFWILIIVTVPETR 253
Cdd:COG2271   285 LGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 100-253 7.45e-09

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 58.16  E-value: 7.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 100 IAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAGGAP 179
Cdd:TIGR00711  28 IAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGPL 107

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1940526634 180 LTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGFRWIFWILMAITGAFWILIIVTVPETR 253
Cdd:TIGR00711 108 IPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFILPRDK 181
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 91-262 1.16e-08

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 57.19  E-value: 1.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  91 GSISSGATQIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRL 170
Cdd:cd17359    18 GVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARI 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 171 IGGFAGGAPLTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVF--------SGYIGLDLGFRWIFWILMAITGAFW 242
Cdd:cd17359    98 IGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVnylianagGADWLGAEGWRWMLGLEAIPAILFL 177

                         170       180
                  ....*....|....*....|
gi 1940526634 243 ILIIvTVPETRHSIILQRKT 262
Cdd:cd17359   178 LGML-FIPESPRWLVSKGKP 196
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 93-247 6.28e-08

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 54.53  E-value: 6.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  93 ISSGATQIAEEF--HVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRL 170
Cdd:cd17316    18 IGFVAPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRF 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 171 IGGFAGGAPLTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIAL----VFSGYIGLDLGFRWIFWI--LMAITGAFWIL 244
Cdd:cd17316    98 LQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAAlvasLLIPLLSGDWGWRILFLIgaLPALLALLLRR 177


                  ...
gi 1940526634 245 IIV 247
Cdd:cd17316   178 RTL 180
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 100-271 1.39e-07

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 53.90  E-value: 1.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 100 IAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAGGAP 179
Cdd:TIGR00895  43 ISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGL 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 180 LTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGFRWIFWILMAITGAFWILIIVTVPEtrhSIILQ 259
Cdd:TIGR00895 123 MPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPE---SIDFL 199

                         170
                  ....*....|....
gi 1940526634 260 --RKTKRVRKQMQK 271
Cdd:TIGR00895 200 vsKRPETVRRIVNA 213
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
102-214 2.12e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 53.05  E-value: 2.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 102 EEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAGGAPLT 181
Cdd:COG2814   236 EVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFP 315

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1940526634 182 NTGGSISDLWARNESGGAMAVYGLSSTFGPPIA 214
Cdd:COG2814   316 LLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 76-271 3.87e-07

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 52.58  E-value: 3.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  76 TCVVSMLNVVTCLCAGSISSGATQIAEE----FHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFI 151
Cdd:cd17358     4 TFVANLGSFSFGIAVGWSSPALPSLMSDnslsLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCIL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 152 FQLPIALAQNIGTILVCRLIGGFAGGAPLTNTGGSISDLWARNESGGAMAVYGLSSTFGppIALVFsgYIGLDLGFRWIF 231
Cdd:cd17358    84 GWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIG--ILLGY--VLGSFLPWRTLA 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1940526634 232 WILMAITGAFWILIIVtVPETRHSIILQRKTKRVRKQMQK 271
Cdd:cd17358   160 LIGAIPPVVFLILLFF-IPESPRWLAKKGREEEAEKSLQF 198
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 100-248 4.41e-07

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 51.82  E-value: 4.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 100 IAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAGGAP 179
Cdd:cd17365    25 LAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAA 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 180 LTNTGGSISDLWARNESGGAMAVYGLsstfGPPIALVFSGYIGLDL----GFRWIFWI----------LMAITGAFWILI 245
Cdd:cd17365   105 MPNAITLVSEYAPARRRSLAVTLMFC----GYPLGAALGGFLAAALipafGWRSVFLLggvpplillpLLRGTLLLWVTF 180


                  ...
gi 1940526634 246 IVT 248
Cdd:cd17365   181 FMG 183
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 85-253 6.58e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 51.42  E-value: 6.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  85 VTCLCAGSISSGAT--------QIAEEFH-VSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLP 155
Cdd:cd17473     2 ITLLLASTLTVMAGaaiapalpAIAQHFVpNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 156 IALAQNIGTILVCRLIGGFAGGAPLTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGlDLGFRWIFWI-L 234
Cdd:cd17473    82 GLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWRAPFLVyL 160

                         170
                  ....*....|....*....
gi 1940526634 235 MAItgAFWILIIVTVPETR 253
Cdd:cd17473   161 LAL--PVLILVLLFLPEPA 177
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 122-277 7.38e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 51.44  E-value: 7.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 122 FAIGPVLLAPLS----EYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAGGAPLTNTGGSISDLWARNESG 197
Cdd:cd17489    40 FTLAALLARPFAgrllDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRG 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 198 GAMAVYGLSST----FGPPIALVFSGYigldLGFRWIFWILMAIT-GAFWILIIVTVPETRHSIILQRKTKRVRKQMQKE 272
Cdd:cd17489   120 EGIGYYGLATTlamaLGPALGLFLYQH----LGFAVLFIVAAVLAlLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKK 195


                  ....*
gi 1940526634 273 NLKSA 277
Cdd:cd17489   196 VLPPA 200
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 91-253 1.16e-06

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 50.65  E-value: 1.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  91 GSISSGATQIAEEFHV--SSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVC 168
Cdd:cd17315    14 GVINGALLYIAKDLGFglSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 169 RLIGGFAGGAPLTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGFRW-IFWILMAITGAFWILIIV 247
Cdd:cd17315    94 RFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPGWWrLMFALAAVPALLQLLLMF 173


                  ....*.
gi 1940526634 248 TVPETR 253
Cdd:cd17315   174 FLPESR 179
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
104-264 1.34e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 50.67  E-value: 1.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 104 FHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQ--NIGTILVCRLIGGFAGGAPLT 181
Cdd:COG2211   259 LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILV 338

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 182 NTGGSISDL-------WARNESGGAMAVYGLSSTFG----PPIALVFSGYIGLD----------LGFRWIFWILMAIT-- 238
Cdd:COG2211   339 LPWAMLADVvdydewkTGRRREGLYFGIFTFAIKLGqalaGALAGLLLALFGYVagaaqspsalTGIRLLFFLLPAVLll 418

                         170       180
                  ....*....|....*....|....*.
gi 1940526634 239 GAFWILIIVTVPETRHSIILQRKTKR 264
Cdd:COG2211   419 LAALLLLFYPLTRERHAEIRAELAAR 444
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 84-503 2.00e-06

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 49.88  E-value: 2.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  84 VVTCLCAGSISSGATQIAEEFHV---SSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQ 160
Cdd:cd17330     6 FLDALGFGIVFPVLPFYVREFNKlgaSGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 161 NIGTILVCRLIGGFAGGApLTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGFRWIFWILMAITGA 240
Cdd:cd17330    86 NLWLLFLARFLDGLTGGN-VSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 241 FWILIIVTVPETRhsiilqrktkrvrkqmqkenlksaesahdvnsahrkglhQLFAITLtrpfrflisepitLFSAIYNG 320
Cdd:cd17330   165 NLVLVLFFLPPLR---------------------------------------RLLLVYF-------------LIALAFAG 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 321 FLYGLVYLFNEAFplvfgpgkghGFNGGATGLTFLGLAIGPLVAFCFyplqeryYLRRVKenngKGVPEARMWmaRGGAF 400
Cdd:cd17330   193 LESVFSLFLKDRF----------GFSPSQIGLLLALVGIAGILAQLL-------LIPRLA----KRLGERKLL--RLGLL 249

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 401 LIPISLFWFGWTSyrSVHWIVPIIASAFFGAGI-YIVILSILNYVVDSYQTysASALAGVILVRNLVGAGFPLFATQMYE 479
Cdd:cd17330   250 LAIIGLLLLPFAS--SVPLLVLAAAILAFGTGIvFPALSALLSKSVPSKEQ--GKAQGIIQSLQSLARIIGPLLAGPLYS 325

                         410       420
                  ....*....|....*....|....
gi 1940526634 480 RLGYEWASSLLGFLAILLVPIPFI 503
Cdd:cd17330   326 FLGPGVPFLLAAGLLLIALFLLSL 349
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 77-253 2.46e-06

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 49.57  E-value: 2.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  77 CVVSMLNVVTCLCAGSISSGATQIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPI 156
Cdd:cd17476     1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 157 ALAQNIGTILVCRLIGGFAGGAPLTNtggSISdLWARNESGG-----AMAVYGLSSTFGPPIALVFSGYIGLDLGFRWIF 231
Cdd:cd17476    81 GFSPNFIFFIICRALQGLGPAFLLPN---AMA-LLGRTYPPGprkniVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIF 156

                         170       180
                  ....*....|....*....|....
gi 1940526634 232 WIlMAITGAFW--ILIIVTVPETR 253
Cdd:cd17476   157 WF-LAILAAIVavAAIFWTSPSFI 179
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
100-173 2.82e-06

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 49.55  E-value: 2.82e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1940526634 100 IAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGG 173
Cdd:PRK15402   39 VVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQG 112
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 88-272 4.74e-06

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 48.86  E-value: 4.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  88 LCAGSISSGATQIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILV 167
Cdd:cd17333    10 LTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVV 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 168 CRLIGGFAGGAPLTNTGGSISDLWARNeSGGAMAV----YGLSSTFGPPIALVFsgyigLDLGFRWiFWILMaITGAFWI 243
Cdd:cd17333    90 LMFLAGLGAGILDTGANTFVGALFEES-SATRLNVlhgfFGLGALIGPLIATSL-----LTSELSW-SWAYL-IIGLIYL 161

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1940526634 244 LIIVTV-----PETRHSIILQRKTKRVRKQMQKE 272
Cdd:cd17333   162 LLAILIlltlfPELPSARNPQQSVGAFSASASRL 195
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 82-247 8.79e-06

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 48.39  E-value: 8.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  82 LNVVTCLCAGS-ISSGATQIAEEFHVSSEvTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQ 160
Cdd:cd06179     5 LAYFAQLFGVTlPAAVLPFIVADLGPSSN-STWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 161 NIGTILVCRLIGGFAGGApLTNTGGSISDL----WARNESGGAMAVYGLSSTFGPPIALVFSgyIGLDLGFRWIFWILMA 236
Cdd:cd06179    84 SVNMLIGGQALIGIGAGT-QGLGAAVASELvpnkYRGLVQGVVNLVASPGSALGPLIAGALV--EANAAGWRWIFYINAI 160

                         170
                  ....*....|.
gi 1940526634 237 ITGAFWILIIV 247
Cdd:cd06179   161 FNALALILLFF 171
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 98-238 1.86e-05

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 46.83  E-value: 1.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  98 TQIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSE-YFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAG 176
Cdd:cd17490   219 PLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYkKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGT 298

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1940526634 177 GAPLTN-TGGSISDLwARNESGGAM----AVYGLSSTFGPpialVFSGYIGLDLGFRWIFWILMAIT 238
Cdd:cd17490   299 GILFPLlMSLSIEGV-PAEQRSTAMgffqAIYALGMFLGP----VLVGIISEAFGLQTGFFVIGVIA 360
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 77-250 2.43e-05

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 46.84  E-value: 2.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  77 CVVSMLNVVTCLCAGSISSGATQI---AEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIIS--WFVLFI 151
Cdd:cd17318    21 AIVAMVNSTATHDNNNTSTDKDTLpveAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSilITALLT 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 152 FQLPIALAQNIGTILVCRLIGGFAGGApltnTGGSISDLWAR----NESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGF 227
Cdd:cd17318   101 LLTPLAARGGYGALIVLRILQGLAQGV----TFPAMHALWAKwappLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGW 176

                         170       180
                  ....*....|....*....|...
gi 1940526634 228 RWIFWILMAITGAFWILIIVTVP 250
Cdd:cd17318   177 PSIFYIFGGLGLLWCLLWFFLVL 199
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
99-248 3.04e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 46.39  E-value: 3.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  99 QIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAGGA 178
Cdd:COG0738    33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGL 112

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1940526634 179 PLTNTGGSISDLWARNES---GGAMAVYGLSSTFGPpiaLVFSGYI--GLDLGFRWIFWILMAITGAFWILIIVT 248
Cdd:COG0738   113 LDVAANPYVAALGPETAAsrlNLLHAFFSLGALLGP---LLGGLLIllGLSLSWHLPYLILAVLLLLLALLFLRS 184
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 132-267 5.04e-05

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 45.67  E-value: 5.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 132 LSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGfaGGAPLTNTGGSISDLWARNESGGAMAVYGLSSTFGP 211
Cdd:cd17472    55 LSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG--SGAISSVVMALLADLTREENRTKAMALIGASIGIAF 132

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 212 PIALVFSGYIGLDLGFRWIFWI--LMAITGAFWILIIV--TVPETRHSIILQRKTKRVRK 267
Cdd:cd17472   133 AISMVLGPLLAAHLGVSGLFLItaILSLVSLLILLFFVpdPPKIVQISEKEKKKLKKLLK 192
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
100-254 2.27e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 43.72  E-value: 2.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 100 IAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQ-NIGTILVCRLIGGFAGGA 178
Cdd:COG2223   232 LVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALGG 311

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 179 PLTNTGGSISDLWARNESGGAM----AVYGLSSTFGPPIALVFSGYIGldlGFRWIFWILMAITGAFWILIIVTVPETRH 254
Cdd:COG2223   312 GNGAVFALVPDIFPTKNAGAVYglvgAAGGLGGFLGPLLFGALLDATG---SYTAAFLVFAVLALVALVLTLLLYRRPRR 388
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 116-218 3.01e-04

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 43.03  E-value: 3.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 116 SMY-ILGFAIGPVLLApLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAGGAPLTNTgGSISDLWARN 194
Cdd:cd17389    71 SLFsLLQFLSSPITGA-ASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLST-AIVADVTSPK 148

                          90       100
                  ....*....|....*....|....*...
gi 1940526634 195 ESGGAMAVYG----LSSTFGPPIALVFS 218
Cdd:cd17389   149 KRSKGMALIGvafsLGFIIGPMIGAYFA 176
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 100-264 3.15e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 43.06  E-value: 3.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 100 IAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRqpVYIISWFVLF--IFQLPIALAQNIGTILVCRLIGGFAGG 177
Cdd:cd17371    25 LIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGR--VRVLVITILLfaVFTLLCGFAQNYWQLLILRALAGLGFG 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 178 APLTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVFS----GYIGLDLGFRWIFWIlmAITGAFWILII-VTVPET 252
Cdd:cd17371   103 GEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAallfPLLPPEIAWRVLFLL--GALPALLVLFIrRFVKEP 180

                         170
                  ....*....|..
gi 1940526634 253 rhSIILQRKTKR 264
Cdd:cd17371   181 --PQWQAARAAR 190
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 84-245 3.31e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 42.93  E-value: 3.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  84 VVTCLCAGSISSGATQI----AEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALA 159
Cdd:cd17477   194 LLGAFVAGFLEGAFYSLlplyGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLV 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 160 QNIGTIL--VCRLIGGFAGgaPLTNTGGS-ISDLWARNESGGAMA----VYGLSSTFGPPIALVFSGYIGLDlgfrWIFW 232
Cdd:cd17477   274 PGLPLALlvLLFLWGGAAG--PLYTLALAlAGDRLPGDELVAANAalllLYGLGSVIGPLLAGALMDAFGPH----GLFL 347

                         170
                  ....*....|...
gi 1940526634 233 ILMAITGAFWILI 245
Cdd:cd17477   348 FLAAVALLFLLFL 360
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
196-505 3.63e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.97  E-value: 3.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 196 SGGAMAVYGLSSTFGPPIALVFSGyiGLDLGFRWIFWILMAITGAFWILIIVTVPEtrhsiilqrktkRVRKQMQKENLK 275
Cdd:COG2211   153 FAFAGLGGLLASVLPPPLVAAFGG--DAALGYRLTALIFAVLGLLAFLLTFFGTKE------------RPVPEEEKVSLK 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 276 saesahdvnsahrKGLHQLFAItltRPFRFLISepITLFSAIYNGFLYGLVYLFNEAfplvfgpgkghgFNGGATGLTFL 355
Cdd:COG2211   219 -------------ESLKALLKN---RPFLLLLL--AYLLFFLALALVAALLLYYFKY------------VLGLSAALVGL 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 356 GLAIGPLVAFCFYPLQERyYLRRVKenngkgvpeaRMWMARGGAFLIPISLFWFGWTSYRSVHW-IVPIIASAFFGAGIY 434
Cdd:COG2211   269 LLALYFLAALLGAPLWPR-LAKRFG----------KKKAFIIGLLLAALGLLLLFFLGPGNLWLlLVLAALAGIGLGAIL 337

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 435 IVILSILNYVVDSYQTYSASALAGVI-----LVRNLVGAGFPLFATQMYERLGY----EWASSLLGFLAILLVPIPFIFF 505
Cdd:COG2211   338 VLPWAMLADVVDYDEWKTGRRREGLYfgiftFAIKLGQALAGALAGLLLALFGYvagaAQSPSALTGIRLLFFLLPAVLL 417
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 91-252 4.58e-04

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 42.64  E-value: 4.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  91 GSISSGATQIAEEFHVSSEVT---TLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILV 167
Cdd:cd17360    14 GVISGALLYIKDDLGEVVLSTgwqELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIV 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 168 CRLIGGFAGG-----APLTntggsISDLWARNESGGAMAVYGLSSTFGPPIALVF-SGYIGLDLGFRWIFWiLMAITGAF 241
Cdd:cd17360    94 GRVLVGLGVGiasmtVPLY-----IAEAAPPRIRGRLVTINVLFITGGQFVAYVInGAFSYLPGGWRWMLG-LAAVPAVL 167

                         170
                  ....*....|.
gi 1940526634 242 WILIIVTVPET 252
Cdd:cd17360   168 QFIGLLFLPES 178
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 98-243 6.74e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 41.82  E-value: 6.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  98 TQIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIIS--WFVLFIFQLPIALAQNIGTILVCRLIGGFA 175
Cdd:cd17316   202 TYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGliLSGILALPLFYLLSGSPTLLLLLLFILSFF 281

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1940526634 176 GGAPLTNTGGSISDLWARNE----SGGAMAVYGLSSTFGPPIALVFSGYIGLDLGFRWIFWILMAITGAFWI 243
Cdd:cd17316   282 VGGVWGALYAYLAELFPTEVratgVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 97-233 7.79e-04

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 41.87  E-value: 7.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  97 ATQIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAG 176
Cdd:PRK11551   38 APRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGL 117

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1940526634 177 GAPLTNTGGSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGFRWIFWI 233
Cdd:PRK11551  118 GGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYV 174
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 85-271 1.11e-03

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 41.54  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  85 VTCLCAGSISSGATQIAEEFHVSSE---VTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQN 161
Cdd:TIGR00898 100 CLDGWEYSYDTFSSTIVTEWDLVCEdawKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPN 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 162 IGTILVCRLIGGFAGGapltntGGSISD--LWARNESGGAMAVYGLSSTFGPPIALVF-SGYIGLDLGFRWIFWILMAIT 238
Cdd:TIGR00898 180 YTVFLVFRLLVGMGIG------GIWVQAvvLNTEFLPKKQRAIVGTLIQVFFSLGLVLlPLVAYFIPDWRWLQLAVSLPT 253

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1940526634 239 GAFWILIIVtVPETRHSIILQRKTKRVRKQMQK 271
Cdd:TIGR00898 254 FLFFLLSWF-VPESPRWLISQGRIEEALKILQR 285
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 79-249 1.25e-03

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 41.00  E-value: 1.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  79 VSMLNVVTCLCAGS---ISSGATQIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFV--LFIFQ 153
Cdd:cd17380     1 VILLFLATCICYADrvnMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALwsLATLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 154 LPIALAQNIGTILVCRLIGGFAGGAPLTntggSISDLWARN----ESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGFRW 229
Cdd:cd17380    81 TPLLAYSSLPLLILSRILLGLGEGVHFP----SMTSLFSRWvpvsERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPS 156

                         170       180
                  ....*....|....*....|
gi 1940526634 230 IFwILMAITGAFWILIIVTV 249
Cdd:cd17380   157 VF-YFFGLLGLLWALVWLIY 175
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 107-197 1.60e-03

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 41.06  E-value: 1.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 107 SSEVTTLCLSMYiLGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAGGAPLTNTGGS 186
Cdd:cd17438    33 SSNKGMLGLIVY-LGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAY 111

                          90
                  ....*....|.
gi 1940526634 187 ISDLWARNESG 197
Cdd:cd17438   112 FSEFLAREKRG 122
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 93-253 1.67e-03

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 40.68  E-value: 1.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  93 ISSGATQIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIG 172
Cdd:cd17328    18 IAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALV 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 173 GF--AGGAPLTNTggSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIG-LDLGFRWIFWILMAITGAFWILIIVTV 249
Cdd:cd17328    98 GIgeASYSPIAPT--IIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAqATGGWRWAFRVTGVLGVLLAILLLLFV 175


                  ....
gi 1940526634 250 PETR 253
Cdd:cd17328   176 REPP 179
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 106-246 1.68e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 40.62  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 106 VSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCrLIGGFAGGAPLTNTGG 185
Cdd:cd17478   227 YSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILL-VLAGFLLFASFPVTVV 305

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1940526634 186 SISDLWARNESGGAMAVYGLSSTFGPPIALVFsGYIGLDLGFRWIFWILMAITGAFWILII 246
Cdd:cd17478   306 LAQELLPGNVGLASGLMMGLSFGLGGIGAPVL-GALADAFGLESVLLILALLPLLGALLAF 365
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 94-180 1.74e-03

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 40.53  E-value: 1.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  94 SSGATQIAEEFHV---SSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCR- 169
Cdd:cd17377    21 SSSFTSIVSEWFLvgnAAYKVSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRf 100

                          90
                  ....*....|.
gi 1940526634 170 LIGGFAGGAPL 180
Cdd:cd17377   101 LVGVMNGGMSL 111
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 104-197 1.90e-03

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 41.12  E-value: 1.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 104 FHVSSEVTTLCLS---------MYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGF 174
Cdd:TIGR01299 188 FVLPSAEKDLCIPdsgkgmlglIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGF 267

                          90       100
                  ....*....|....*....|...
gi 1940526634 175 AGGAPLTNTGGSISDLWARNESG 197
Cdd:TIGR01299 268 GIGGAIPIVFSYFAEFLAQEKRG 290
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 122-254 2.01e-03

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 40.70  E-value: 2.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 122 FAIGPVLLAP----LSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAgGAPLTNTGGSISDLWA---RN 194
Cdd:cd17388    47 YALMQFIFAPilgaLSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGIT-GATGAVAAAYIADVTPpeqRA 125

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1940526634 195 ESGGAM-AVYGLSSTFGPPIALVFSGYigldlGFRWIFWILMAITGAFWILIIVTVPETRH 254
Cdd:cd17388   126 RNFGLLgAAFGLGFIAGPALGGLLGEI-----SPRAPFLVAAGLNGLNFLLGLFVLPESLP 181
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
61-255 2.05e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 40.63  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  61 SDNPRCWPRWQKWYITCVVSMLNVVTCLCAGSISSGATQIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQP 140
Cdd:COG2807     5 SSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLER 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 141 VYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFA---GGAPLTntgGSISDlWARNESGGAMAVYGLSSTFGPPIALVF 217
Cdd:COG2807    85 TLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGiavGNVLLP---GLIKR-WFPDRVGLMTGLYTAAMGLGAALAAGL 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1940526634 218 SGYIGLDLGFRWIFW---ILMAITGAFWILIIVTVPETRHS 255
Cdd:COG2807   161 TVPLAAALGWRGALAvwaLLALLALLLWLPLLRRRPAAAAA 201
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 102-222 2.15e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 40.36  E-value: 2.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 102 EEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISW-----FVLFIFQLPIalaqNIGTILVCRLIGGFAG 176
Cdd:cd17371   238 GERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFAlgsaiSILLYFFLPL----SPTLILILGFPLGFFA 313

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1940526634 177 GAPLTNTGGSISDLWARNESGGAMavyGLSSTFGPPIALVFSGYIG 222
Cdd:cd17371   314 SGPFSGMGAYLTELFPTAVRATAQ---GFCYNVGRIIGALFPFLVG 356
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 108-271 2.30e-03

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 40.81  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 108 SEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAGGApltntGGSi 187
Cdd:pfam06609  77 SENQGLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLGVAAGP-----AGA- 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 188 SDLWARNESGGAMAVYGLSSTFGPPIALVFSG-YIGLDLG----FRWIFWILMaITGAFWILIIVT---VPETRHsiiLQ 259
Cdd:pfam06609 151 SPLFIGELMSNKTKFLGLLIVSAPTIAMNGAGpYFGQRLAiqgnWRWIFYIYI-IMSAIAVLLIIIwyhPPSFAQ---LH 226

                         170
                  ....*....|..
gi 1940526634 260 RKTKRVRKQMQK 271
Cdd:pfam06609 227 GKKARKRDELAK 238
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 100-247 2.81e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 40.25  E-value: 2.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 100 IAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEY-FGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAGGA 178
Cdd:cd17474   225 LELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGL 304

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1940526634 179 --PLTNTggSISDLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGFRWIFWILMAIT-GAFWILIIV 247
Cdd:cd17474   305 nlPLLTT--LVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIAlAAAVLLALL 374
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 129-247 3.17e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 39.94  E-value: 3.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 129 LAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAGGAPLtntgGSISDLWARNES-GGAMAVYGLSS 207
Cdd:cd17391   260 LGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLL----PAINSLLAKITPkEVAGRIFGYNQ 335

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1940526634 208 TF---GPPIALVFSGYIGLDLGFRWIFWI--LMAITGAFWILIIV 247
Cdd:cd17391   336 SFqylGNVAGPLLGSAIAAHFGYRAVFVVtaLLVLLNAIWSFIFL 380
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
 118-174 4.36e-03

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 39.42  E-value: 4.36e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1940526634 118 YILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGF 174
Cdd:cd17373    34 LLLGLIFGYLILGCIADRFGRRPVLLFSLILILIFGLTVALAVSVTMFSTLRFLEGF 90
emrD PRK11652
multidrug transporter EmrD;
99-253 4.51e-03

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 39.51  E-value: 4.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634  99 QIAEEFHVSSEVTTLCLSMYILGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAGGA 178
Cdd:PRK11652   33 DMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGV 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1940526634 179 pltntGGSIS-----DLWARNESGGAMAVYGLSSTFGPPIALVFSGYIGLDLGFRWIFWILMAITGAFWILIIVTVPETR 253
Cdd:PRK11652  113 -----GGVMArtlprDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMPETR 187
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 120-176 5.22e-03

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 39.26  E-value: 5.22e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1940526634 120 LGFAIGPVLLAPLSEYFGRQPVYIISWFVLFIFQLPIALAQNIGTILVCRLIGGFAG 176
Cdd:cd17379    44 LGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFG 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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