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Conserved domains on  [gi|1860686221|gb|KAF5384547|]
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hypothetical protein D9757_006424 [Collybiopsis confluens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CUE_Cue1p_like cd14424
CUE domain found in yeast ubiquitin-binding protein CUE1 (Cue1p), CUE4 (Cue4p) and similar ...
 798-834 1.31e-16

CUE domain found in yeast ubiquitin-binding protein CUE1 (Cue1p), CUE4 (Cue4p) and similar proteins; Cue1p, also called coupling of ubiquitin conjugation to ER degradation protein 1 or kinetochore-defect suppressor 4, is encoded by the open reading frame (ORF) YMR264W in yeast. It is an N-terminally membrane-anchored endoplasmic reticulum (ER) protein essential for the activity of the two major yeast RING finger ubiquitin ligases (E3s) implicated in ER-associated degradation (ERAD). It interacts with the ERAD ubiquitin-conjugating enzyme (E2) Ubc7p in vivo, stimulates Ubc7p E2 activity, and further activates ER-associated protein degradation. Cue1p contains a CUE domain which binds ubiquitin much more weakly than those of other CUE domain containing proteins. It also has an Ubc7p binding-domain at the C-terminal region which is required for Ubc7p-dependent ubiquitylation and for degradation of substrates in the ER. This family also includes Cue4p, also called coupling of ubiquitin conjugation to ER degradation protein 4. It is encoded by the open reading frame (ORF) YML101C in yeast. Cue4p contains a CUE domain which shows high level of similarity with that of Cue1p.


:

Pssm-ID: 270607  Cd Length: 37  Bit Score: 74.09  E-value: 1.31e-16
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1860686221 798 QDMVDTVGNMFPDLPRDNIRYDLLRTGSVETTTNKIL 834
Cdd:cd14424     1 PAMIESVQTMFPQLSVAQIRYDLLRTGSVEATVERIL 37
MUG113 pfam13455
Meiotically up-regulated gene 113; This is a family of fungal proteins found to be ...
 470-552 2.65e-09

Meiotically up-regulated gene 113; This is a family of fungal proteins found to be up-regulated in meiosis.


:

Pssm-ID: 372608  Cd Length: 73  Bit Score: 54.22  E-value: 2.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221 470 LKIGRAVNVVKRLNQWGKQCGSKEQVLRGWYPgevdpdsddtddptfvgqsmmkgrvmaggkGVWCHRLERLIHLELADL 549
Cdd:pfam13455   1 YKIGRTRNVEKRLKELNSQSPFKFDVVASYES------------------------------TNDARKLERLLHRELKEY 50


                  ...
gi 1860686221 550 AVH 552
Cdd:pfam13455  51 RLN 53
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 15-333 5.32e-09

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 60.72  E-value: 5.32e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221   15 SVSPTKIPASGAPPRGPRALGQSHASEQAFKE-LAQSMDTLELNGNSPRRVQPLANAHDRYRSEDHDiyAPRHQHTNSAP 93
Cdd:PHA03247  2611 PAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPpPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAS--SPPQRPRRRAA 2688

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221   94 GQFVGGFNSTSAYPPP-----------------PPGQYSAAQVIGPGPL-PRPPQFPTA-VVDTSLTMQYASHGQPPPPS 154
Cdd:PHA03247  2689 RPTVGSLTSLADPPPPpptpepaphalvsatplPPGPAAARQASPALPAaPAPPAVPAGpATPGGPARPARPPTTAGPPA 2768

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221  155 NKHLFMPYGSQAGFGTPPSRPYSAPGPPGFPHP-NTSPYPGPSPLSTPGSSPAHTPAASVP---SSYPIPPHYPSQQAPP 230
Cdd:PHA03247  2769 PAPPAAPAAGPPRRLTRPAVASLSESRESLPSPwDPADPPAAVLAPAAALPPAASPAGPLPpptSAQPTAPPPPPGPPPP 2848

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221  231 PAASAPNSFPPPNPYPSSNPKPGGGRP----------LPTPSLSGTNGNGFGFGALPQPQHLPSSPTRPfLTTQFNSPSA 300
Cdd:PHA03247  2849 SLPLGGSVAPGGDVRRRPPSRSPAAKPaaparppvrrLARPAVSRSTESFALPPDQPERPPQPQAPPPP-QPQPQPPPPP 2927

                          330       340       350
                   ....*....|....*....|....*....|...
gi 1860686221  301 GPIKQNKQQRRPRAtstPPTPITSNSVVTGVSG 333
Cdd:PHA03247  2928 QPQPPPPPPPRPQP---PLAPTTDPAGAGEPSG 2957
 
Name Accession Description Interval E-value
CUE_Cue1p_like cd14424
CUE domain found in yeast ubiquitin-binding protein CUE1 (Cue1p), CUE4 (Cue4p) and similar ...
 798-834 1.31e-16

CUE domain found in yeast ubiquitin-binding protein CUE1 (Cue1p), CUE4 (Cue4p) and similar proteins; Cue1p, also called coupling of ubiquitin conjugation to ER degradation protein 1 or kinetochore-defect suppressor 4, is encoded by the open reading frame (ORF) YMR264W in yeast. It is an N-terminally membrane-anchored endoplasmic reticulum (ER) protein essential for the activity of the two major yeast RING finger ubiquitin ligases (E3s) implicated in ER-associated degradation (ERAD). It interacts with the ERAD ubiquitin-conjugating enzyme (E2) Ubc7p in vivo, stimulates Ubc7p E2 activity, and further activates ER-associated protein degradation. Cue1p contains a CUE domain which binds ubiquitin much more weakly than those of other CUE domain containing proteins. It also has an Ubc7p binding-domain at the C-terminal region which is required for Ubc7p-dependent ubiquitylation and for degradation of substrates in the ER. This family also includes Cue4p, also called coupling of ubiquitin conjugation to ER degradation protein 4. It is encoded by the open reading frame (ORF) YML101C in yeast. Cue4p contains a CUE domain which shows high level of similarity with that of Cue1p.


Pssm-ID: 270607  Cd Length: 37  Bit Score: 74.09  E-value: 1.31e-16
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1860686221 798 QDMVDTVGNMFPDLPRDNIRYDLLRTGSVETTTNKIL 834
Cdd:cd14424     1 PAMIESVQTMFPQLSVAQIRYDLLRTGSVEATVERIL 37
MUG113 pfam13455
Meiotically up-regulated gene 113; This is a family of fungal proteins found to be ...
 470-552 2.65e-09

Meiotically up-regulated gene 113; This is a family of fungal proteins found to be up-regulated in meiosis.


Pssm-ID: 372608  Cd Length: 73  Bit Score: 54.22  E-value: 2.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221 470 LKIGRAVNVVKRLNQWGKQCGSKEQVLRGWYPgevdpdsddtddptfvgqsmmkgrvmaggkGVWCHRLERLIHLELADL 549
Cdd:pfam13455   1 YKIGRTRNVEKRLKELNSQSPFKFDVVASYES------------------------------TNDARKLERLLHRELKEY 50


                  ...
gi 1860686221 550 AVH 552
Cdd:pfam13455  51 RLN 53
PHA03247 PHA03247
large tegument protein UL36; Provisional
 15-333 5.32e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 60.72  E-value: 5.32e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221   15 SVSPTKIPASGAPPRGPRALGQSHASEQAFKE-LAQSMDTLELNGNSPRRVQPLANAHDRYRSEDHDiyAPRHQHTNSAP 93
Cdd:PHA03247  2611 PAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPpPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAS--SPPQRPRRRAA 2688

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221   94 GQFVGGFNSTSAYPPP-----------------PPGQYSAAQVIGPGPL-PRPPQFPTA-VVDTSLTMQYASHGQPPPPS 154
Cdd:PHA03247  2689 RPTVGSLTSLADPPPPpptpepaphalvsatplPPGPAAARQASPALPAaPAPPAVPAGpATPGGPARPARPPTTAGPPA 2768

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221  155 NKHLFMPYGSQAGFGTPPSRPYSAPGPPGFPHP-NTSPYPGPSPLSTPGSSPAHTPAASVP---SSYPIPPHYPSQQAPP 230
Cdd:PHA03247  2769 PAPPAAPAAGPPRRLTRPAVASLSESRESLPSPwDPADPPAAVLAPAAALPPAASPAGPLPpptSAQPTAPPPPPGPPPP 2848

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221  231 PAASAPNSFPPPNPYPSSNPKPGGGRP----------LPTPSLSGTNGNGFGFGALPQPQHLPSSPTRPfLTTQFNSPSA 300
Cdd:PHA03247  2849 SLPLGGSVAPGGDVRRRPPSRSPAAKPaaparppvrrLARPAVSRSTESFALPPDQPERPPQPQAPPPP-QPQPQPPPPP 2927

                          330       340       350
                   ....*....|....*....|....*....|...
gi 1860686221  301 GPIKQNKQQRRPRAtstPPTPITSNSVVTGVSG 333
Cdd:PHA03247  2928 QPQPPPPPPPRPQP---PLAPTTDPAGAGEPSG 2957
CUE pfam02845
CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE ...
 797-835 1.19e-08

CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE domains are related to pfam00627 and this has been confirmed by the structure of the domain. CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2.


Pssm-ID: 427018  Cd Length: 42  Bit Score: 51.71  E-value: 1.19e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1860686221 797 TQDMVDTVGNMFPDLPRDNIRYDLLR-TGSVETTTNKILE 835
Cdd:pfam02845   1 NEQMLETLKEMFPDLDEEVIRAVLEAsNGNVEAAINALLE 40
CUE smart00546
Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also ...
 796-835 9.36e-06

Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2. Ponting (Biochem. J.) "Proteins of the Endoplasmic reticulum" (in press)


Pssm-ID: 214715  Cd Length: 43  Bit Score: 43.25  E-value: 9.36e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1860686221  796 VTQDMVDTVGNMFPDLPRDNIRYDLL-RTGSVETTTNKILE 835
Cdd:smart00546   1 ENDEALHDLKEMFPNLDEEVIEAVLEaNTGNVEATINNLLE 41
GGN pfam15685
Gametogenetin; GGN is a family of proteins largely found in mammals. It reacts with POG in the ...
 71-221 3.32e-04

Gametogenetin; GGN is a family of proteins largely found in mammals. It reacts with POG in the maturation of sperm and is expressed virtually only in the testis. It is found to be associated with the intracellular membrane, binds with GGNBP1 and may be involved in vesicular trafficking.


Pssm-ID: 434857 [Multi-domain]  Cd Length: 668  Bit Score: 44.37  E-value: 3.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221  71 HDRYRSEDHDIYAPRHQhtnsaPGQFVGGFNStsayPPPPPGQYSaaqvigPGPLPRPPQfPTAVVDTSLTMQYASHGQP 150
Cdd:pfam15685 366 HFRFNGAGGGIGAPRRR-----AAALSGPWGS----PPPPPGKAH------PIPGPRRPA-PALLAPPMFIFPAPTNGEP 429

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1860686221 151 PPPSnkhlfmPYGSQAGFGTPPSRPYSAPGPPGFPHPNTSPYPGPSPLS-----TPGSSPAHTPAASVPSSYPIPP 221
Cdd:pfam15685 430 VRPG------PPAPQALLPRPPPPTPPATPPPVPPPIPQLPALQPMPLAaarppTPRPCPGHGESALAPAPTAPLP 499
 
Name Accession Description Interval E-value
CUE_Cue1p_like cd14424
CUE domain found in yeast ubiquitin-binding protein CUE1 (Cue1p), CUE4 (Cue4p) and similar ...
 798-834 1.31e-16

CUE domain found in yeast ubiquitin-binding protein CUE1 (Cue1p), CUE4 (Cue4p) and similar proteins; Cue1p, also called coupling of ubiquitin conjugation to ER degradation protein 1 or kinetochore-defect suppressor 4, is encoded by the open reading frame (ORF) YMR264W in yeast. It is an N-terminally membrane-anchored endoplasmic reticulum (ER) protein essential for the activity of the two major yeast RING finger ubiquitin ligases (E3s) implicated in ER-associated degradation (ERAD). It interacts with the ERAD ubiquitin-conjugating enzyme (E2) Ubc7p in vivo, stimulates Ubc7p E2 activity, and further activates ER-associated protein degradation. Cue1p contains a CUE domain which binds ubiquitin much more weakly than those of other CUE domain containing proteins. It also has an Ubc7p binding-domain at the C-terminal region which is required for Ubc7p-dependent ubiquitylation and for degradation of substrates in the ER. This family also includes Cue4p, also called coupling of ubiquitin conjugation to ER degradation protein 4. It is encoded by the open reading frame (ORF) YML101C in yeast. Cue4p contains a CUE domain which shows high level of similarity with that of Cue1p.


Pssm-ID: 270607  Cd Length: 37  Bit Score: 74.09  E-value: 1.31e-16
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1860686221 798 QDMVDTVGNMFPDLPRDNIRYDLLRTGSVETTTNKIL 834
Cdd:cd14424     1 PAMIESVQTMFPQLSVAQIRYDLLRTGSVEATVERIL 37
CUE_AUP1_AMFR_like cd14376
CUE domain found in ancient ubiquitous protein 1 (AUP1), autocrine motility factor receptor ...
 798-834 7.39e-10

CUE domain found in ancient ubiquitous protein 1 (AUP1), autocrine motility factor receptor (AMFR) and similar proteins; AUP1 is a component of the HRD1-SEL1L endoplasmic reticulum (ER) quality control complex and is essential for US11-mediated dislocation of class I MHC heavy chains. AMFR is an internalizing cell surface glycoprotein that is localized in both plasma membrane caveolae and the ER, and involves in the regulation of cellular adhesion, proliferation, motility and apoptosis, as well as in the process of learning and memory. Cue1p is an N-terminally membrane-anchored endoplasmic reticulum (ER) protein essential for the activity of the two major yeast RING finger ubiquitin ligases (E3s) implicated in ER-associated degradation (ERAD). This family also includes plant E3 ubiquitin protein ligases RIN2, RIN3, and similar proteins. Comparing with other CUE domain-containing proteins, some family members from higher eukaryotes do not bind monoubiquitin efficiently, since they carry LP, rather than FP among CUE domains.


Pssm-ID: 270559  Cd Length: 37  Bit Score: 54.79  E-value: 7.39e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1860686221 798 QDMVDTVGNMFPDLPRDNIRYDLLRTGSVETTTNKIL 834
Cdd:cd14376     1 EEMVEQVQEVFPHIPREAIRRDLQRTNSVDLTINNIL 37
MUG113 pfam13455
Meiotically up-regulated gene 113; This is a family of fungal proteins found to be ...
 470-552 2.65e-09

Meiotically up-regulated gene 113; This is a family of fungal proteins found to be up-regulated in meiosis.


Pssm-ID: 372608  Cd Length: 73  Bit Score: 54.22  E-value: 2.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221 470 LKIGRAVNVVKRLNQWGKQCGSKEQVLRGWYPgevdpdsddtddptfvgqsmmkgrvmaggkGVWCHRLERLIHLELADL 549
Cdd:pfam13455   1 YKIGRTRNVEKRLKELNSQSPFKFDVVASYES------------------------------TNDARKLERLLHRELKEY 50


                  ...
gi 1860686221 550 AVH 552
Cdd:pfam13455  51 RLN 53
PHA03247 PHA03247
large tegument protein UL36; Provisional
 15-333 5.32e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 60.72  E-value: 5.32e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221   15 SVSPTKIPASGAPPRGPRALGQSHASEQAFKE-LAQSMDTLELNGNSPRRVQPLANAHDRYRSEDHDiyAPRHQHTNSAP 93
Cdd:PHA03247  2611 PAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPpPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAS--SPPQRPRRRAA 2688

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221   94 GQFVGGFNSTSAYPPP-----------------PPGQYSAAQVIGPGPL-PRPPQFPTA-VVDTSLTMQYASHGQPPPPS 154
Cdd:PHA03247  2689 RPTVGSLTSLADPPPPpptpepaphalvsatplPPGPAAARQASPALPAaPAPPAVPAGpATPGGPARPARPPTTAGPPA 2768

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221  155 NKHLFMPYGSQAGFGTPPSRPYSAPGPPGFPHP-NTSPYPGPSPLSTPGSSPAHTPAASVP---SSYPIPPHYPSQQAPP 230
Cdd:PHA03247  2769 PAPPAAPAAGPPRRLTRPAVASLSESRESLPSPwDPADPPAAVLAPAAALPPAASPAGPLPpptSAQPTAPPPPPGPPPP 2848

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221  231 PAASAPNSFPPPNPYPSSNPKPGGGRP----------LPTPSLSGTNGNGFGFGALPQPQHLPSSPTRPfLTTQFNSPSA 300
Cdd:PHA03247  2849 SLPLGGSVAPGGDVRRRPPSRSPAAKPaaparppvrrLARPAVSRSTESFALPPDQPERPPQPQAPPPP-QPQPQPPPPP 2927

                          330       340       350
                   ....*....|....*....|....*....|...
gi 1860686221  301 GPIKQNKQQRRPRAtstPPTPITSNSVVTGVSG 333
Cdd:PHA03247  2928 QPQPPPPPPPRPQP---PLAPTTDPAGAGEPSG 2957
CUE pfam02845
CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE ...
 797-835 1.19e-08

CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE domains are related to pfam00627 and this has been confirmed by the structure of the domain. CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2.


Pssm-ID: 427018  Cd Length: 42  Bit Score: 51.71  E-value: 1.19e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1860686221 797 TQDMVDTVGNMFPDLPRDNIRYDLLR-TGSVETTTNKILE 835
Cdd:pfam02845   1 NEQMLETLKEMFPDLDEEVIRAVLEAsNGNVEAAINALLE 40
CUE_AMFR cd14421
CUE domain found in autocrine motility factor receptor (AMFR) and similar proteins; AMFR is an ...
 798-836 2.36e-07

CUE domain found in autocrine motility factor receptor (AMFR) and similar proteins; AMFR is an internalizing cell surface glycoprotein that is localized in both plasma membrane caveolae and the endoplasmic reticulum (ER), and involves in the regulation of cellular adhesion, proliferation, motility and apoptosis, as well as in the process of learning and memory. It is also called ER-protein gp78 that has been identified as a RING finger-dependent ubiquitin protein ligase (E3) implicated in degradation from the ER. AMFR contains an N-terminal RING-finger domain and a C-terminal CUE domain.


Pssm-ID: 270604  Cd Length: 41  Bit Score: 48.03  E-value: 2.36e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1860686221 798 QDMVDTVGNMFPDLPRDNIRYDLLRTGSVETTTNKILER 836
Cdd:cd14421     1 DAMAHQVQEMFPQVPLSVILADLRLTRSVEVTIENILEG 39
T5orf172 pfam10544
T5orf172 domain; This domain was identified by Iyer and colleagues.
 450-548 3.52e-07

T5orf172 domain; This domain was identified by Iyer and colleagues.


Pssm-ID: 463143  Cd Length: 99  Bit Score: 49.39  E-value: 3.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221 450 GFIYSFEirdpkNPSPPTLSLKIGRAVNVVKRLNQWGKQCGSKEQVLRGWYPGEVDPDSddtddptfvgqsmmkgrvmag 529
Cdd:pfam10544   1 GYIYILT-----NPSNPGLIFKIGRTSNLQRRLRELSKSSTSVPFEFSVIYEIKVRKVP--------------------- 54

                          90
                  ....*....|....*....
gi 1860686221 530 gkgvWCHRLERLIHLELAD 548
Cdd:pfam10544  55 ----NAFRLERLIHKELAD 69
PHA03247 PHA03247
large tegument protein UL36; Provisional
 60-324 2.87e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 2.87e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221   60 SPRRVQPLANAHDRYRSedhdiyAPRHQHTNSAPGQFVGGFNSTS----------AYPPPPPGQYSAAQVIG-----PGP 124
Cdd:PHA03247  2574 APRPSEPAVTSRARRPD------APPQSARPRAPVDDRGDPRGPAppsplppdthAPDPPPPSPSPAANEPDphpppTVP 2647

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221  125 LPRPPQFPTAVVDTSLTMQYASHGQPPPPSN-------KHLFMPYGSQAGFGTPPSRPysaPGPPGFPHPNTSPYPGP-S 196
Cdd:PHA03247  2648 PPERPRDDPAPGRVSRPRRARRLGRAAQASSppqrprrRAARPTVGSLTSLADPPPPP---PTPEPAPHALVSATPLPpG 2724

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221  197 PLSTPGSSPAhTPAASVPSSYPIPPHYPSQQAPPPAASAPNSFPPPNPYPSSNPKPGGGRPLPTPSLSGTNGNGFGFGAL 276
Cdd:PHA03247  2725 PAAARQASPA-LPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD 2803

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*...
gi 1860686221  277 PQPQHLPSSPTRPFLTTQFNSPSAGPIKQNKQQRRPRATSTPPTPITS 324
Cdd:PHA03247  2804 PADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP 2851
PHA03247 PHA03247
large tegument protein UL36; Provisional
 102-332 6.19e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 6.19e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221  102 STSAYPPPPPGQYSAAQVIGPGPLPRPPQFPTAVVDTSLTMQYASHGQPPPPSNKHLFM--------PYGSQAGFGTPPS 173
Cdd:PHA03247  2794 SRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLggsvapggDVRRRPPSRSPAA 2873

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221  174 RPYSAPGPPG--FPHPNTSPYPGPSPLSTPGSSPAHTPAAsvpssyPIPPHYPSQQAPPpaasapnsfpppnpypssnpk 251
Cdd:PHA03247  2874 KPAAPARPPVrrLARPAVSRSTESFALPPDQPERPPQPQA------PPPPQPQPQPPPP--------------------- 2926

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221  252 PGGGRPLPTPSLSGTNGNGFGFGAlPQPQHLPSSPTrPFLTTQFNSPSAGPIKQNKQQRRPRATSTPPTPITSNSVVTGV 331
Cdd:PHA03247  2927 PQPQPPPPPPPRPQPPLAPTTDPA-GAGEPSGAVPQ-PWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRV 3004


                   .
gi 1860686221  332 S 332
Cdd:PHA03247  3005 S 3005
CUE smart00546
Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also ...
 796-835 9.36e-06

Domain that may be involved in binding ubiquitin-conjugating enzymes (UBCs); CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2. Ponting (Biochem. J.) "Proteins of the Endoplasmic reticulum" (in press)


Pssm-ID: 214715  Cd Length: 43  Bit Score: 43.25  E-value: 9.36e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1860686221  796 VTQDMVDTVGNMFPDLPRDNIRYDLL-RTGSVETTTNKILE 835
Cdd:smart00546   1 ENDEALHDLKEMFPNLDEEVIEAVLEaNTGNVEATINNLLE 41
CUE_AUP1 cd14420
CUE domain found in ancient ubiquitous protein 1 (AUP1) and similar proteins; AUP1 is a ...
 800-835 3.24e-05

CUE domain found in ancient ubiquitous protein 1 (AUP1) and similar proteins; AUP1 is a component of the HRD1-SEL1L endoplasmic reticulum (ER) quality control complex and is essential for US11-mediated dislocation of class I MHC heavy chains. It also binds to the membrane-proximal KVGFFKR motif of the cytoplasmic tail of the integrin alphaCTs that plays a crucial role in the inside-out signaling of alpha(IIb)beta(3). AUP1 is found in both the ER and in lipid droplets. It contains two conserved cytoplasmic domains, an acyltransferase domain, a CUE domain and an E2 ubiquitin conjugase G2 (Ube2g2)-binding domain (G2BR). The acyltransferase domain transfers fatty acids onto phospholipids and CUE domain participates in ubiquitin binding or in recruitment of ubiquitin-conjugating enzymes to the site of dislocation.


Pssm-ID: 270603  Cd Length: 45  Bit Score: 41.82  E-value: 3.24e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1860686221 800 MVDTVGNMFPDLPRDNIRYDLLRTGSVETTTNKILE 835
Cdd:cd14420     5 MAQQVKEVLPHVPLHVIRRDLEKTRNVDTTITNILE 40
PHA03247 PHA03247
large tegument protein UL36; Provisional
 10-224 3.74e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.01  E-value: 3.74e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221   10 PTKGTSVSPTKIPASGAPPRGPRALGQSHASEQAFKELAQSMDTLElngnSPRRVQPLANAHDRYRSEDHDIYAPRhqhT 89
Cdd:PHA03247  2754 PARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLP----SPWDPADPPAAVLAPAAALPPAASPA---G 2826

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221   90 NSAPGQFVGGFNSTSAYPPPPPGQYSAAQVIGPGPLPR--PPQFPTAVVDTSLTMQYASHGQPP-PPSNKHLFMPYGSQA 166
Cdd:PHA03247  2827 PLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRrpPSRSPAAKPAAPARPPVRRLARPAvSRSTESFALPPDQPE 2906

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1860686221  167 GFGTPPS--------------RPYSAPGPPGFPHPNTSPYPGPSPLSTP-GSSPAHTPAASVPSSYP-----IPPHYP 224
Cdd:PHA03247  2907 RPPQPQAppppqpqpqpppppQPQPPPPPPPRPQPPLAPTTDPAGAGEPsGAVPQPWLGALVPGRVAvprfrVPQPAP 2984
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
93-319 4.92e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 47.18  E-value: 4.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221  93 PGQFVGGFNSTSAYPPP---PPGQYSAAQVIGPGPLPRPPQFPTAVVDTSLTMQYASHGQPPPPSNKHLfmPYGSQAGFG 169
Cdd:PRK12323  365 PGQSGGGAGPATAAAAPvaqPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEAL--AAARQASAR 442

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221 170 TPPSRPYSAPGPPGFPHPNTSP----YPGPSPLSTPGSSPAHTPAASVPSSYPIPPHYPSQqapppaasapnsfpppnpy 245
Cdd:PRK12323  443 GPGGAPAPAPAPAAAPAAAARPaaagPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELP------------------- 503

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1860686221 246 pssnpkpgGGRPLPTPSLSGTNGNGFGFGALPQPQHLPSSPTRPfltTQFNSPSAGPIKQNKQQRRPRATSTPP 319
Cdd:PRK12323  504 --------PEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFE---TLAPAPAAAPAPRAAAATEPVVAPRPP 566
GGN pfam15685
Gametogenetin; GGN is a family of proteins largely found in mammals. It reacts with POG in the ...
 71-221 3.32e-04

Gametogenetin; GGN is a family of proteins largely found in mammals. It reacts with POG in the maturation of sperm and is expressed virtually only in the testis. It is found to be associated with the intracellular membrane, binds with GGNBP1 and may be involved in vesicular trafficking.


Pssm-ID: 434857 [Multi-domain]  Cd Length: 668  Bit Score: 44.37  E-value: 3.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221  71 HDRYRSEDHDIYAPRHQhtnsaPGQFVGGFNStsayPPPPPGQYSaaqvigPGPLPRPPQfPTAVVDTSLTMQYASHGQP 150
Cdd:pfam15685 366 HFRFNGAGGGIGAPRRR-----AAALSGPWGS----PPPPPGKAH------PIPGPRRPA-PALLAPPMFIFPAPTNGEP 429

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1860686221 151 PPPSnkhlfmPYGSQAGFGTPPSRPYSAPGPPGFPHPNTSPYPGPSPLS-----TPGSSPAHTPAASVPSSYPIPP 221
Cdd:pfam15685 430 VRPG------PPAPQALLPRPPPPTPPATPPPVPPPIPQLPALQPMPLAaarppTPRPCPGHGESALAPAPTAPLP 499
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
117-221 4.08e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 44.00  E-value: 4.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221 117 AQVIGPGPLPRPPQFPTAVVDTSLTMQYAshgqPPPPSNKHLFMPYGSQAGFGTPPSRPYSAPGPPGFPHPNTSPYPGPS 196
Cdd:PRK14971  360 AQLTQKGDDASGGRGPKQHIKPVFTQPAA----APQPSAAAAASPSPSQSSAAAQPSAPQSATQPAGTPPTVSVDPPAAV 435

                          90       100
                  ....*....|....*....|....*
gi 1860686221 197 PLSTPGSSPAHTPAASVPSSYPIPP 221
Cdd:PRK14971  436 PVNPPSTAPQAVRPAQFKEEKKIPV 460
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 104-323 1.47e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 42.33  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221 104 SAYPPPPPGQYSAAQVIGPGPLPRPPQFPTAVVDTSltmqYASHGQPPPPSNKHLfmpygSQAGFGTPPSR---PYSAPG 180
Cdd:pfam09770 108 AARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRTG----YEKYKEPEPIPDLQV-----DASLWGVAPKKaaaPAPAPQ 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221 181 PPGFPHPN-------------------TSPYPGPSPLSTPGSSPAHTPAASVPSSYPIPPHYPSQQAPPPAASAPNSFPP 241
Cdd:pfam09770 179 PAAQPASLpapsrkmmsleeveaamraQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPG 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221 242 PNPYPSSNPKPGGGRPLPTPSLSGTNGNGFGFGALP---QPQHLPSSPTRPFLTT----QFNSPSAGPIKQNKQQRRPRA 314
Cdd:pfam09770 259 QGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPvpvQPTQILQNPNRLSAARvgypQNPQPGVQPAPAHQAHRQQGS 338


                  ....*....
gi 1860686221 315 TSTPPTPIT 323
Cdd:pfam09770 339 FGRQAPIIT 347
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 16-216 1.96e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 41.95  E-value: 1.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221  16 VSPTKIPASGAPPrgpralgQSHASEQAFKELAQSMDTLE-----LNGNSPRRVQPLANAHdryRSEDHDIYAPRHQHTN 90
Cdd:pfam09770 165 VAPKKAAAPAPAP-------QPAAQPASLPAPSRKMMSLEeveaaMRAQAKKPAQQPAPAP---AQPPAAPPAQQAQQQQ 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221  91 SAPGQFVGG--FNSTSAYPPPPPGQYSAAQVigpgpLPRPPQFPTAV-VDTSLTMQYASHGQPPPPsnkhlfMPYGSQAg 167
Cdd:pfam09770 235 QFPPQIQQQqqPQQQPQQPQQHPGQGHPVTI-----LQRPQSPQPDPaQPSIQPQAQQFHQQPPPV------PVQPTQI- 302

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1860686221 168 FGTPPSRPYSAPGPPGFPHPNTSPYPGPSPLSTPGSSPAHTPAASVPSS 216
Cdd:pfam09770 303 LQNPNRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPIITHPQQ 351
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 103-326 2.32e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.06  E-value: 2.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221 103 TSAYPPPPPGQYSAAQVIGPGPLPRPPQFPTAVVDTSLTMQyashGQPPPPSNKHLFMPYGSQAGFGTPPSrPYSA--PG 180
Cdd:pfam03154 178 SGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPP----NQTQSTAAPHTLIQQTPTLHPQRLPS-PHPPlqPM 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221 181 PPGFPHPNTSPYPGPSP-LSTPG--------SSPAHTPAASVPSSYPIPPHYPSqqapppaasapnsfpppnpypssnpk 251
Cdd:pfam03154 253 TQPPPPSQVSPQPLPQPsLHGQMppmphslqTGPSHMQHPVPPQPFPLTPQSSQ-------------------------- 306

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221 252 pGGGRPLPTPSLSGTNGNGFGFGAlPQPQHLPSSPTR-------PFLTTQFNSPSAGPIKQ--NKQQRRPRATSTPPTPI 322
Cdd:pfam03154 307 -SQVPPGPSPAAPGQSQQRIHTPP-SQSQLQSQQPPReqplppaPLSMPHIKPPPTTPIPQlpNPQSHKHPPHLSGPSPF 384


                  ....
gi 1860686221 323 TSNS 326
Cdd:pfam03154 385 QMNS 388
PHA03378 PHA03378
EBNA-3B; Provisional
 123-309 3.26e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.59  E-value: 3.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221 123 GPLP-RPPQFPTAVVDTSLTMQYASHGQPPPPSNKHLFMPYGSQAGFGTPPSRPYSAPGPPGFPHPNTSPYPGPSPLSTP 201
Cdd:PHA03378  648 FPTPhQPPQVEITPYKPTWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPP 727

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221 202 GSSP-AHTPAASVPSSYPIPphypsqqappPAASAPNSFPPPNPYPSSNPKPGGGRPLPTPSLSGTNGNGFGFGALPQPQ 280
Cdd:PHA03378  728 AAAPgRARPPAAAPGRARPP----------AAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQ 797

                         170       180       190
                  ....*....|....*....|....*....|
gi 1860686221 281 HLPSSPTRPFLTTQFNSP-SAGPIKQNKQQ 309
Cdd:PHA03378  798 PPPQAGPTSMQLMPRAAPgQQGPTKQILRQ 827
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 107-215 3.43e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.61  E-value: 3.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221  107 PPPPPGQYSAAQvigpGPLPRPPQFPTAVVDTSLTMQYASHGQPPPPSnkhlfmPYGSQAGFGTPPSRPYSAPGPPGFPH 186
Cdd:PRK10263   771 PVAPQPQYQQPQ----QPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQ------PQYQQPQQPVAPQPQYQQPQQPVAPQ 840

                           90       100
                   ....*....|....*....|....*....
gi 1860686221  187 PNTSpYPGPSPLSTPGSSPAHTPAASVPS 215
Cdd:PRK10263   841 PQDT-LLHPLLMRNGDSRPLHKPTTPLPS 868
PHA03378 PHA03378
EBNA-3B; Provisional
 107-214 3.80e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.21  E-value: 3.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221 107 PPPPPGQYSAAQViGPGPLPRPPQFPTAVVDTSLTMQYAshgQPPPPSNKHLFMPYGSQAGFGTPPSRPYSAPGP---PG 183
Cdd:PHA03378  697 PPRAPTPMRPPAA-PPGRAQRPAAATGRARPPAAAPGRA---RPPAAAPGRARPPAAAPGRARPPAAAPGRARPPaaaPG 772

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1860686221 184 FPHPNTSPYPGPSPLSTPGSSPAHTPAASVP 214
Cdd:PHA03378  773 APTPQPPPQAPPAPQQRPRGAPTPQPPPQAG 803
MISS pfam15822
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ...
 108-222 5.94e-03

MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.


Pssm-ID: 318115 [Multi-domain]  Cd Length: 238  Bit Score: 39.58  E-value: 5.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221 108 PPPPGQYSAAQVIGPGPlprPPQFPTAVVD-TSLTMQYASHGQP--PPPSNKHLFMPYGSQA----GFGTPPSRPYSAPG 180
Cdd:pfam15822  92 PPPGGPYPAPTVPGPGP---IGPYPTPNMPfPELPRPYGAPTDPaaAAPSGPWGSMSSGPWApgmgGQYPAPNMPYPSPG 168

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1860686221 181 PPGFPHPNTSPYPGPS---------PLSTPGSSPAHTPAASVPSSYPIPPH 222
Cdd:pfam15822 169 PYPAVPPPQSPGAAPPvpwgtvppgPWGPPAPYPDPTGSYPMPGLYPTPNN 219
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 22-210 9.12e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.15  E-value: 9.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221   22 PASGAPPRGPRALGQSHASEQAFKELAQSMDTLELNGNSPRRVQPLANAHDRYRSEDHDIYAPRHQHT----NSAPGQfv 97
Cdd:PHA03307   760 NPSLVPAKLAEALALLEPAEPQRGAGSSPPVRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDggseSSGPAR-- 837

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1860686221   98 ggfNSTSAYPPPPPGQYSAAQVIGPGPLPRPPQFPTAVVDTSLTMQyASHGQPPPPSNKHLFMPYGSQAGFGTPPSRPYS 177
Cdd:PHA03307   838 ---PPGAAARPPPARSSESSKSKPAAAGGRARGKNGRRRPRPPEPR-ARPGAAAPPKAAAAAPPAGAPAPRPRPAPRVKL 913

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1860686221  178 APGPPGFPHPNTS----PypgPSPLSTPGSSPAHTPA 210
Cdd:PHA03307   914 GPMPPGGPDPRGGfrrvP---PGDLHTPAPSAAALAA 947
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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