|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NLS1_MFSD2A |
cd17451 |
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of ... |
41-494 |
0e+00 |
|
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of transporters; Sodium-dependent lysophosphatidylcholine (LPC) symporter 1 (NLS1) is also called major facilitator superfamily domain-containing protein 2A (MFSD2A). NLS1/MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. It also transports the essential omega-3 fatty acid docosahexaenoic acid (DHA), which is essential for normal brain growth and cognitive function, in the form of LPC into the brain across the blood-brain barrier. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. NLS1/MFSD2A belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341009 Cd Length: 419 Bit Score: 774.76 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 41 KLCYAVGGAPYQITGCALGFFLQIYLLDVALLDPFYASVILFVGRAWDAITDPTVGFLVSRTPWTRFGRMMPWIILSTPF 120
Cdd:cd17451 1 KLCYAIGGAPYQITGCALGFFLQIYLLDVAQLDPFYASIILFVGRAWDAITDPTVGFFVSKSPWTRFGRLMPWIIFSTPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 121 AVMSYFLIWYVPPVDQTKVVWYLIFYCLFQTLQTCFHVPYSALTMFISSEQKERDSATAYRMTVEVLGTVIGTGIQGQIV 200
Cdd:cd17451 81 AVLSYFLIWFVPDFSQGKVMWYLLFYCLFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTVLGTAIQGQIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 201 GMAnapcipvgndlnatfrnsgseanitqpdlsldkvrnAYMIASGVICAIYVLCAITLFCGVKERKENSKVHS-ERMSF 279
Cdd:cd17451 161 GMA------------------------------------AYMIAAGVICAIYVLCAIILFLGVREQREPCELKSqKPVSF 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 280 FRGIRLVMGHGPYAKLVMGFLFTSLAFMLLEGNFALFCSYTLGFRDDFQNVLLVVMLSATLTIPFWQWFLTRFGKKTAVY 359
Cdd:cd17451 205 FKGLKLVMSHGPYIKLITGFLFTSLAFMLLEGNFALFCTYTLGFRNDFQNILLVIMLSATLTIPFWQWFLTRFGKKTAVY 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 360 VGTTIVIPFLITVVLMKSNLIVTYVIAIASGVSIAAAFLLPWSMLPDVVDDFKVLNPESQGHEAIFYSFYVFFTKFASGV 439
Cdd:cd17451 285 IGISSAVPFLILVVLVESNLIVTYVVSVAAGVSVAAAFLLPWSMLPDVVDDFKLKNPDSQGHEAIFYSFYVFFTKFASGV 364
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 1832123188 440 SLGISTLSLDFAGYVTRGCTQPKAVDVTLKVLVSAAPVALIFIGLLIFTSYPINE 494
Cdd:cd17451 365 SLGISTLSLDFAGYQTRGCSQPEEVNLTLKMLVSAAPVVLILLGLLLFKLYPIDE 419
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
43-494 |
5.05e-113 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 357.00 E-value: 5.05e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 43 CYAVGGAPYQITGCALGFFLQIYLLDVALLDPFYASVILFVGRAWDAITDPTVGFLVSRTPwTRFGRMMPWIILSTPFAV 122
Cdd:pfam13347 1 GYGSGALAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTR-TRWGRRRPWLLLSAIILA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 123 MSYFLIWYVPPVDQ-TKVVWYLIFYCLFQTLQTCFHVPYSALTMFISSEQKERDSATAYRMTVEVLGTVIGTGIQGQIVG 201
Cdd:pfam13347 80 VSFILLFTPPELGRaPLFIWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 202 MANAPCIPvgndlnatfrnsgseanitqpdlsldkvRNAYMIASGVICAIYVLCAITLFCGVKE----RKENSKVHSERM 277
Cdd:pfam13347 160 ILGGTGLE----------------------------RKGYRIFALIGAVLMLLGVIITAAGTKErvsmRSKEDTGQKEAG 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 278 SFFRGIRLVMGHGPYAKLVMGFLFTSLAFMLLEGNFALFCSYTLGFRDDFQNVLLVVMLSATLTIPFWQWFLTRFGKKTA 357
Cdd:pfam13347 212 SLLDMLKEVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNT 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 358 VYVGTTIVIPFLITVVLM-KSNLIVTYVIAIASGVSIAAAFLLPWSMLPDVVDDFKVLNPESqgHEAIFYSFYVFFTKFA 436
Cdd:pfam13347 292 YILGALITIAGFALALLLgPNNTLLFLVLYIIIGFGYGSSFFLPWSMLADVVDYGELRTGKR--REGTFFAMWSFISKLA 369
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 1832123188 437 SGVSLGISTLSLDFAGYVTRGCTQPKAVDVTLKVLVSAAPVALIFIGLLIFTSYPINE 494
Cdd:pfam13347 370 TGVGLGVSGLLLSAFGYNAGDSVQSPQAVTAIRLLYAVLPAVLFLVALLLLYFYPLDR 427
|
|
| PRK08560 |
PRK08560 |
tyrosyl-tRNA synthetase; Validated |
558-886 |
1.64e-95 |
|
tyrosyl-tRNA synthetase; Validated
Pssm-ID: 236286 [Multi-domain] Cd Length: 329 Bit Score: 306.79 E-value: 1.64e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 558 DKKFNLITRNLQEVLGEEKLK-LILMERELKVYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAFLDNmKAP 636
Cdd:PRK08560 2 EERLELITRNTEEVVTEEELReLLESKEEPKAYIGFEPSGKIHLGHLLTMNKLADLQKAGFKVTVLLADWHAYLND-KGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 637 WELLELRVKYYEQVIKAMlesiGVPLDKLKFVKGTEYQLSREYTLDVYRLSSMVTEHDAKKAGAEVVKQVEHPLLSGLLY 716
Cdd:PRK08560 81 LEEIRKVAEYNKKVFEAL----GLDPDKTEFVLGSEFQLDKEYWLLVLKLAKNTTLARARRSMTIMGRRMEEPDVSKLVY 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 717 PGLQALDEEYLKVDAQFGGVDQRKIFTLAEKYLPSLGYTKRIHMMNPMVPGLTGS--KMSSSEEESKIDLLDKKEDIKKK 794
Cdd:PRK08560 157 PLMQVADIFYLDVDIAVGGMDQRKIHMLAREVLPKLGYKKPVCIHTPLLTGLDGGgiKMSKSKPGSAIFVHDSPEEIRRK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 795 LKKAFCEPGNIQNNGVLSFVKHVLFPLHSEFAIKRDPKFGGDKVYTFYEELEKDFAEERIHPGDLKASVEVALDKLLDPI 874
Cdd:PRK08560 237 IKKAYCPPGEVEGNPVLEIAKYHIFPRYDPFVIERPEKYGGDLEYESYEELERDYAEGKLHPMDLKNAVAEYLIEILEPV 316
|
330
....*....|..
gi 1832123188 875 RKKFETPELKKL 886
Cdd:PRK08560 317 REYLEEGPELLE 328
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
30-509 |
4.90e-92 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 301.44 E-value: 4.90e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 30 SEEKRHLSVCNKLCYAVGGAPYQITGCALGFFLQIYLLDVALLDPFYASVILFVGRAWDAITDPTVGFLVSRTpWTRFGR 109
Cdd:COG2211 1 TAAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRT-RTRWGR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 110 MMPWIILSTPFAVMSYFLIWYVPPVDQT-KVVWYLIFYCLFQTLQTCFHVPYSALTMFISSEQKERDSATAYRMTVEVLG 188
Cdd:COG2211 80 RRPWILIGAIPLALSFVLLFTAPDLSPTgKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 189 TVIGTGIQGQIVGManapcipVGNDlnatfrnsgseanitqpdlsldkVRNAYMIASGVICAIYVLCAITLFCGVKERKE 268
Cdd:COG2211 160 GLLASVLPPPLVAA-------FGGD-----------------------AALGYRLTALIFAVLGLLAFLLTFFGTKERPV 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 269 NSKvhsERMSFFRGIRLVMGHGPYAKLVMGFLFTSLAFMLLEGNFALFCSYTLGFRDDFQNVLLVVM-LSATLTIPFWQW 347
Cdd:COG2211 210 PEE---EKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYfLAALLGAPLWPR 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 348 FLTRFGKKTAVYVGTTI-VIPFLITVVLMKSNLIVTYVIAIASGVSIAAAFLLPWSMLPDVVDDFKVLNPESQghEAIFY 426
Cdd:COG2211 287 LAKRFGKKKAFIIGLLLaALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRR--EGLYF 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 427 SFYVFFTKFASGVSLGISTLSLDFAGYVTrGCTQPKAVDVTLKVLVSAAPVALIFIGLLIFTSYPINEKRRQGNRKLLNE 506
Cdd:COG2211 365 GIFTFAIKLGQALAGALAGLLLALFGYVA-GAAQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAA 443
|
...
gi 1832123188 507 QRE 509
Cdd:COG2211 444 RRA 446
|
|
| TyrRS_core |
cd00805 |
catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) ... |
586-870 |
1.56e-79 |
|
catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) catalytic core domain. TyrRS is a homodimer which attaches Tyr to the appropriate tRNA. TyrRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formationof the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173902 [Multi-domain] Cd Length: 269 Bit Score: 261.00 E-value: 1.56e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 586 LKVYWGTATTG-KPHVAYFVPMSKIADFLKAGCEVTILFADLHAFLDNMK--------APWELLELRVKYYEQVIKAMLE 656
Cdd:cd00805 1 LKVYIGFDPTApSLHLGHLVPLMKLRDFQQAGHEVIVLIGDATAMIGDPSgkseerklLDLELIRENAKYYKKQLKAILD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 657 SIgvPLDKLKFVKGTEYQLSrEYTLDVYRLSSMVTEHDAKKAGAEVVKQ--VEHPLLSGLLYPGLQALDEEYLKVDAQFG 734
Cdd:cd00805 81 FI--PPEKAKFVNNSDWLLS-LYTLDFLRLGKHFTVNRMLRRDAVKVRLeeEEGISFSEFIYPLLQAYDFVYLDVDLQLG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 735 GVDQRKIFTLAEKYLPSLGYTKRIHMMNPMVPGLTGSKM-SSSEEESKIDLLDKKEDIKKKLKKAFCEPgniqnngVLSF 813
Cdd:cd00805 158 GSDQRGNITLGRDLIRKLGYKKVVGLTTPLLTGLDGGKMsKSEGNAIWDPVLDSPYDVYQKIRNAFDPD-------VLEF 230
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1832123188 814 VKHVLFPLHSEfaikrdpkfggdkvytfYEELEKDFAEErIHPGDLKASVEVALDKL 870
Cdd:cd00805 231 LKLFTFLDYEE-----------------IEELEEEHAEG-PLPRDAKKALAEELTKL 269
|
|
| tRNA-synt_1b |
pfam00579 |
tRNA synthetases class I (W and Y); |
583-871 |
1.33e-61 |
|
tRNA synthetases class I (W and Y);
Pssm-ID: 395461 [Multi-domain] Cd Length: 292 Bit Score: 212.14 E-value: 1.33e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 583 ERELKVYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAFL-DNMKAPWELLELRVKYYEQVIKAMLeSIGVP 661
Cdd:pfam00579 3 NRPLRVYSGIDPTGPLHLGYLVPLMKLRQFQQAGHEVFFLIGDLHAIIgDPSKSPERKLLSRETVLENAIKAQL-ACGLD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 662 LDKLKFVKGTEYQLSREYTLDVYRLSSMVTEHDAKKAGaEVVKQVEHP---LLSGLLYPGLQALDEEYLKVDAQFGGVDQ 738
Cdd:pfam00579 82 PEKAEIVNNSDWLEHLELAWLLRDLGKHFSLNRMLQFK-DVKKRLEQGpgiSLGEFTYPLLQAYDILLLKADLQPGGSDQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 739 RKIFTLAEKYLPSLGY---TKRIHMMNPMVPGLTG-SKMSSSEEESKIDLLDKKEDIKKKLKKAFCEPGNiqNNGVLSFV 814
Cdd:pfam00579 161 WGNIELGRDLARRFNKkifKKPVGLTNPLLTGLDGgKKMSKSAGNSAIFLDDDPESVYKKIQKAYTDPDR--EVRKDLKL 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1832123188 815 KHVLFPlhseFAIKRDPKFGGDKVYTFYEELEKDFAEERIHPGDLKASVEVALDKLL 871
Cdd:pfam00579 239 FTFLSN----EEIEILEAELGKSPYREAEELLAREVTGLVHGGDLKKAAAEAVNKLL 291
|
|
| PLN02610 |
PLN02610 |
probable methionyl-tRNA synthetase |
894-1076 |
2.91e-59 |
|
probable methionyl-tRNA synthetase
Pssm-ID: 215329 [Multi-domain] Cd Length: 801 Bit Score: 218.88 E-value: 2.91e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 894 KNKNAVKVNPKKAEEEdEIIPSRLDLRVGKIVGVEKHPAADTLYLEKIDIGEEQPRTVVSGLVAYVSQEELQDRLVVVLC 973
Cdd:PLN02610 621 GKKAGGGGKSKAAAER-EIDVSRLDIRVGLIVKAEKHPDADSLYVEEIDVGEGAPRTVVSGLVKYIPLEEMQNRKVCVLC 699
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 974 NLKPQKMRGIESQAMLLCASvDGEPKRVEPLDPPEGSAPGERVFVDGYtSGTPDDELKPKKKVFEKIQVDMKISDECIAQ 1053
Cdd:PLN02610 700 NLKPAAMRGIKSQAMVLAAS-NSDHTKVELVEPPESAAVGERVTFPGF-EGEPDDVLNPKKKVWETLQPDLHTNSELVAC 777
|
170 180
....*....|....*....|...
gi 1832123188 1054 WNKKDLITKLGKITCKTLKGGSI 1076
Cdd:PLN02610 778 YKDVPFTTSAGVCKVASIANGSI 800
|
|
| tRNA_bind_EMAP-II_like |
cd02799 |
tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of ... |
914-1017 |
3.28e-57 |
|
tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae Arc1p, human p43 and EMAP2. CeMetRS and hTyrRS aminoacylate their cognate tRNAs. Arc1p is a transactivator of yeast methionyl-tRNA and glutamyl-tRNA synthetases. This domain has general tRNA binding properties. In a subset of this family this domain has the added capability of a cytokine. For example the p43 component of the Human aminoacyl-tRNA synthetase complex is cleaved to release EMAP-II cytokine. EMAP-II has multiple activities during apoptosis, angiogenesis and inflammation and participates in malignant transformation. A EMAP-II-like cytokine also is released from hTyrRS upon cleavage. The active cytokine heptapeptide locates to this domain.
Pssm-ID: 239198 [Multi-domain] Cd Length: 105 Bit Score: 192.06 E-value: 3.28e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 914 PSRLDLRVGKIVGVEKHPAADTLYLEKIDIGEEQPRTVVSGLVAYVSQEELQDRLVVVLCNLKPQKMRGIESQAMLLCAS 993
Cdd:cd02799 3 PSRLDIRVGKILKVRKHPDADSLYVEEIDLGEEEPRTIVSGLVKFVPLEQMQNRLVVVLCNLKPRKMRGVKSQGMVLCAS 82
|
90 100
....*....|....*....|....
gi 1832123188 994 VDGEPKrVEPLDPPEGSAPGERVF 1017
Cdd:cd02799 83 NADHEK-VELLEPPEGAKPGERVT 105
|
|
| tyrS |
TIGR00234 |
tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up ... |
557-879 |
6.05e-49 |
|
tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up tryptophanyl-tRNA synthetases at scores of 0 and below. The proteins found by this model have a deep split between two groups. One group contains bacterial and organellar eukaryotic examples. The other contains archaeal and cytosolic eukaryotic examples. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 272976 [Multi-domain] Cd Length: 378 Bit Score: 178.74 E-value: 6.05e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 557 PDKKFNLITRNLQEVLGEEKLKLI--LMERELKVYWGTATTG-KPHVAYFVPMSKIADFLKAGCEVTILFADLHAFLDNM 633
Cdd:TIGR00234 1 MNNILLLLTKRGLEVQTPEEEKDLlkLLERPLKLYLGFDPTApSLHLGHLVPLLKLRDFQQAGHEVIVLLGDFTALIGDP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 634 KAPWELLELR-----VKYYEQVIKAMLESIGVplDKLKFVKGTEYQLSREYTLDVYRLSSMVTEHDAKKAGAEVVKQVEH 708
Cdd:TIGR00234 81 TGKSEVRKILtreevQENAENIKKQIARFLDF--EKAKFVYNSEWLLKLNYTDFIRLLGKIFTVNRMLRRDAFSSRFEEN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 709 PLLSGLLYPGLQALDEEYLKVDAQFGGVDQ----RKIFTLAEKYLPSLGYTKRIHMMNP---MVPGLTGS-KMSS--SEE 778
Cdd:TIGR00234 159 ISLHEFIYPLLQAYDFVYLNVDLQLGGSDQwfniRKGRDLARENLPSLQFGLTVPLLTPadgEKMGKSLGgAVSLdeGKY 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 779 ESKIDLLDKKEDIKKKLKKAFCEPGN----------------IQNNGVLSFVKHVLFP------------------LHSE 824
Cdd:TIGR00234 239 DFYQKVINTPDELVKKYLKLFTFLGLeeieqlvelkgpnpreVKENLALEITKYVHGPeaalaaeeiseaifsgglNPDE 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1832123188 825 FAIKRDPKFGGDKVYTFYEELEKDFAEERIHPGDLK-ASVEVA--LDKLLDPIRKKFE 879
Cdd:TIGR00234 319 VPIFRPEKFGGPITLADLLVLSGLFPSKSEARRDIKnGGVYINgeKVEDLEPIRKELE 376
|
|
| gph |
TIGR00792 |
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ... |
41-496 |
1.98e-44 |
|
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273270 Cd Length: 437 Bit Score: 167.04 E-value: 1.98e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 41 KLCYAVGGAPYQITGCALGFFLQIYLLDVALLDPFYASVILFVGRAWDAITDPTVGFLVSRTPwTRFGRMMPWI-ILSTP 119
Cdd:TIGR00792 1 KLSYGFGDFGNDFIFAIVSTYLLFFYTDVLGLSAAFVGTLFLVARILDAITDPIMGNIVDRTR-TRWGKFRPWLlIGAIP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 120 FAVMSyFLIWYVPPVDQT-KVVWYLIFYCLFQTLQTCFHVPYSALTMFISSEQKERDSATAYRMtvevlgtvIGTGIQGQ 198
Cdd:TIGR00792 80 FSIVL-VLLFTTPDFSGTgKLVYAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRR--------FGATLGGL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 199 IVGMAnapCIPVGNDLNATFRNSGseanitqpdlsldkvrnaYMIASGVICAIYVLCAITLFCGVKERKENSKVHSERMS 278
Cdd:TIGR00792 151 LVAVI---VLPLVSYFGGGDDKFG------------------WFMFALVLALIGVVSLIICFFGTKERYSEIPKNIEKKL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 279 FFRGI-RLVMGHGPYAKLVMGFLFTSLAFMLLEGNFALFCSYTLGFRDDFQNVLLVVMLSATLTIPFWQWFLTRFGKKTA 357
Cdd:TIGR00792 210 SLKQIfKALFKNDQLLILCLAYLFYNLAFNIKNGVQVYYFTYVLGDPELFSYMGSIAIVAGLIGVLLFPRLVKKFGRKIL 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 358 VYVGTTIVIPFLITVVLMKSNLIVTYVIAIASGVSIAAAFLLPWSMLPDVVDDFKVLNpesqGH--EAIFYSFYVFFTKF 435
Cdd:TIGR00792 290 FAGGILLMVLGYLIFFFAGSNLPLILVLIILAGFGQNIVTGLVWALVADTVDYGEWKT----GIraEGLVYSVRTFVRKL 365
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1832123188 436 ASGVSLGISTLSLDFAGYVTrGCTQPKAVDVTLKVLVSAAPVALIFIGLLIFTS-YPINEKR 496
Cdd:TIGR00792 366 GQALAGFFVGLILGIIGYVA-NAAQSPITLNGIKILMFAVPALFLLLAAIIIGRfYKLTEKK 426
|
|
| tRNA_bind |
pfam01588 |
Putative tRNA binding domain; This domain is found in prokaryotic methionyl-tRNA synthetases, ... |
919-1015 |
6.01e-36 |
|
Putative tRNA binding domain; This domain is found in prokaryotic methionyl-tRNA synthetases, prokaryotic phenylalanyl tRNA synthetases the yeast GU4 nucleic-binding protein (G4p1 or p42, ARC1), human tyrosyl-tRNA synthetase, and endothelial-monocyte activating polypeptide II. G4p1 binds specifically to tRNA form a complex with methionyl-tRNA synthetases. In human tyrosyl-tRNA synthetase this domain may direct tRNA to the active site of the enzyme. This domain may perform a common function in tRNA aminoacylation.
Pssm-ID: 396251 [Multi-domain] Cd Length: 96 Bit Score: 131.21 E-value: 6.01e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 919 LRVGKIVGVEKHPAADTLYLEKIDIGEEQPRTVVSGLVAYVSQEELQDRLVVVLCNLKPQKMRGIESQAMLLCASvDGEP 998
Cdd:pfam01588 1 LRVGKVVEAERHPNADKLLVCKVDVGEEEPRQIVSGAVNVYPPEELVGRLVVVVANLKPAKLRGVESEGMILSAE-ELDG 79
|
90
....*....|....*..
gi 1832123188 999 KRVEPLDPPEGSAPGER 1015
Cdd:pfam01588 80 GSVGLLEPPADVPPGTK 96
|
|
| metG_C_term |
TIGR00399 |
methionyl-tRNA synthetase C-terminal region/beta chain; The methionyl-tRNA synthetase (metG) ... |
884-1016 |
3.20e-25 |
|
methionyl-tRNA synthetase C-terminal region/beta chain; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model describes a region of the methionyl-tRNA synthetase that is present at the C-terminus of MetG in some species (E. coli, B. subtilis, Thermotoga maritima, Methanobacterium thermoautotrophicum), and as a separate beta chain in Aquifex aeolicus. It is absent in a number of other species (e.g. Mycoplasma genitalium, Mycobacterium tuberculosis), while Pyrococcus horikoshii has both a full length MetG and a second protein homologous to the beta chain only. Proteins hit by this model should be called methionyl-tRNA synthetase beta chain if and only if the model metG hits a separate protein not also hit by this model. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273059 [Multi-domain] Cd Length: 137 Bit Score: 102.12 E-value: 3.20e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 884 KKLTSLAYPSKNKNAVKVNPKKAEEEDEIIPS-----RLDLRVGKIVGVEKHPAADTLYLEKIDIGEEQpRTVVSGLVAY 958
Cdd:TIGR00399 2 KKIEELKLKGAKKKEKKDEGEKALEPQKETITiddfeKVDLRVGKILKAERVEKSDKLLKLKLDLGDEK-RQIVSGIAGY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1832123188 959 VSQEELQDRLVVVLCNLKPQKMRGIESQAMLLCASVDGepKRVEPLDPPEGSAPGERV 1016
Cdd:TIGR00399 81 YTPEELVGKKVIVVANLKPAKLFGVKSEGMILAAEDDG--KVLFLLSPDQEAIAGERI 136
|
|
| PRK09669 |
PRK09669 |
putative symporter YagG; Provisional |
36-496 |
4.65e-25 |
|
putative symporter YagG; Provisional
Pssm-ID: 236610 Cd Length: 444 Bit Score: 109.81 E-value: 4.65e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 36 LSVCNKLCYAVGGapyqiTGCAL-----GFFLQIYLLDVALLDPFYASVILFVGRAWDAITDPTVGFLVSRTPwTRFGRM 110
Cdd:PRK09669 6 LTTKDKIGYGLGD-----TACNLvwqtvMLFLAYFYTDVFGLSAAIMGTMFLVVRVLDAVTDPLMGALVDRTR-TRHGQF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 111 MPWII-LSTPFAVmSYFLIWYVPPVDQT-KVVWYLIFYCLFQTLQTCFHVPYSALTMFISSEQKERDSATAYRMTVEVLG 188
Cdd:PRK09669 80 RPYLLwFAIPFGV-VCLLTFYTPDFGATgKIIYACVTYILLSLVYTAINVPYCAMPGAITNDPRERHSLQSWRFALSFIG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 189 tvigtgiqGQIVGMANAPCIPVgndlnatfrnsgseanITQPDlsldkVRNAYMIASGVICAIYVLCAITLFCGVKERKE 268
Cdd:PRK09669 159 --------GLIVSVIALPLVDI----------------LGKGD-----EQKGYFYAMMVMGLLGVVLFFCCFFMTKERYT 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 269 NSKVHSErmSFFRGIRLVMGHGPYaKLVMGFLFTSLAFMLLEGNFAL-FCSYTLGfRDDFQNVLLVVMLSATLTIPFWQW 347
Cdd:PRK09669 210 PEVDNSS--SVWKDLKLLLGNSQW-RIMFIFNVVLLTAVVTRGGATLyYVNYVLL-RPDLATLFLVTGMIAGLFGALLSE 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 348 FLtrFGKKTAVYVGTTIVIPFLITVVLM----KSNLIVTYVIAIASGVSIAAAFLLPWSMLPDVVDdfkVLNPES-QGHE 422
Cdd:PRK09669 286 RL--LGKFDRVRAFKWTIVAFVILSALIffipPSNVWLIFALNILFNFIQNLTTPLQWSMFSDVVD---YEEKRSgRRLD 360
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1832123188 423 AIFYSFYVFFTKFasGVSLGISTL--SLDFAGYVTRGCTQPKAVDVTLKVLVSAAPVALIFIGLLIFTSYPINEKR 496
Cdd:PRK09669 361 GLVFSTNLFAIKL--GLAIGGAVVgwILAWVDYVGGAAVQSASVLTTINLLFTVIPGVLFAGMAIILNFYKLNDAR 434
|
|
| EMAP |
COG0073 |
tRNA-binding EMAP/Myf domain [Translation, ribosomal structure and biogenesis]; |
907-1013 |
5.75e-19 |
|
tRNA-binding EMAP/Myf domain [Translation, ribosomal structure and biogenesis];
Pssm-ID: 439843 [Multi-domain] Cd Length: 773 Bit Score: 92.61 E-value: 5.75e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 907 EEEDEIIPSRLD-LRVGKIVGVEKHPAADTLYLEKIDIGEEqPRTVVSGL-VAYVSQ---EELQDRLVVVLCNLKPQKMR 981
Cdd:COG0073 31 EVEDFEKVGGLDgLRVGKVLEAEPHPNADKLLVLQVDVGEE-TRQIVCGApNVYAGDkvpEALVGAQVPGVVNLKPRKIR 109
|
90 100 110
....*....|....*....|....*....|...
gi 1832123188 982 GIESQAMLLCASVDGEPKRVE-PLDPPEGSAPG 1013
Cdd:COG0073 110 GVESEGMLCSAEELGLGEDHDgILELPEDAPPG 142
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NLS1_MFSD2A |
cd17451 |
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of ... |
41-494 |
0e+00 |
|
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of transporters; Sodium-dependent lysophosphatidylcholine (LPC) symporter 1 (NLS1) is also called major facilitator superfamily domain-containing protein 2A (MFSD2A). NLS1/MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. It also transports the essential omega-3 fatty acid docosahexaenoic acid (DHA), which is essential for normal brain growth and cognitive function, in the form of LPC into the brain across the blood-brain barrier. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. NLS1/MFSD2A belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341009 Cd Length: 419 Bit Score: 774.76 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 41 KLCYAVGGAPYQITGCALGFFLQIYLLDVALLDPFYASVILFVGRAWDAITDPTVGFLVSRTPWTRFGRMMPWIILSTPF 120
Cdd:cd17451 1 KLCYAIGGAPYQITGCALGFFLQIYLLDVAQLDPFYASIILFVGRAWDAITDPTVGFFVSKSPWTRFGRLMPWIIFSTPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 121 AVMSYFLIWYVPPVDQTKVVWYLIFYCLFQTLQTCFHVPYSALTMFISSEQKERDSATAYRMTVEVLGTVIGTGIQGQIV 200
Cdd:cd17451 81 AVLSYFLIWFVPDFSQGKVMWYLLFYCLFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTVLGTAIQGQIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 201 GMAnapcipvgndlnatfrnsgseanitqpdlsldkvrnAYMIASGVICAIYVLCAITLFCGVKERKENSKVHS-ERMSF 279
Cdd:cd17451 161 GMA------------------------------------AYMIAAGVICAIYVLCAIILFLGVREQREPCELKSqKPVSF 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 280 FRGIRLVMGHGPYAKLVMGFLFTSLAFMLLEGNFALFCSYTLGFRDDFQNVLLVVMLSATLTIPFWQWFLTRFGKKTAVY 359
Cdd:cd17451 205 FKGLKLVMSHGPYIKLITGFLFTSLAFMLLEGNFALFCTYTLGFRNDFQNILLVIMLSATLTIPFWQWFLTRFGKKTAVY 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 360 VGTTIVIPFLITVVLMKSNLIVTYVIAIASGVSIAAAFLLPWSMLPDVVDDFKVLNPESQGHEAIFYSFYVFFTKFASGV 439
Cdd:cd17451 285 IGISSAVPFLILVVLVESNLIVTYVVSVAAGVSVAAAFLLPWSMLPDVVDDFKLKNPDSQGHEAIFYSFYVFFTKFASGV 364
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 1832123188 440 SLGISTLSLDFAGYVTRGCTQPKAVDVTLKVLVSAAPVALIFIGLLIFTSYPINE 494
Cdd:cd17451 365 SLGISTLSLDFAGYQTRGCSQPEEVNLTLKMLVSAAPVVLILLGLLLFKLYPIDE 419
|
|
| MFS_MFSD2 |
cd17392 |
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator ... |
41-494 |
0e+00 |
|
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator superfamily domain-containing protein 2 (MFSD2) subfamily is composed of two vertebrate members, MFSD2A amd MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD2 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340950 Cd Length: 446 Bit Score: 664.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 41 KLCYAVGGAPYQITGCALGFFLQIYLLDVALLDPFYASVILFVGRAWDAITDPTVGFLVSRTPWTRFGRMMPWIILSTPF 120
Cdd:cd17392 1 KLCYAIGGAPYQMTSSATGFFLQIFLLDVAQMGAFSVSLILFVGRVWDAVTDPLVGYFISRSQRTGIGRLMPWIVFSTPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 121 AVMSYFLIWYVPPVDQTKVVWYLIFYCLFQTLQTCFHVPYSALTMFISSEQKERDSATAYRMTVEVLGTVIGTGIQGQIV 200
Cdd:cd17392 81 IILAYFFLWFLPPFTSLSGLWYLTFYCLFETFMTCFHVPYSALTMFLGGCQRERDSATAYRMTVEVFGTLMGATIQGQIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 201 GMANAPCIpvgNDLNATfrnsgsEANITQPDLSLDKVRNAYMIASGVICAIYVLCAITLFCGVKERKENSKVHS-ERMSF 279
Cdd:cd17392 161 GVAHRPRR---QDCTAT------PGTSDHPVTVLPNTRRAYLIAALVVVVLYFVCCSILFLGVKEQPDPLSPASgPGLSY 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 280 FRGIRLVMGHGPYAKLVMGFLFTSLAFMLLEGNFALFCSYTLGFRDDFQNVLLVVMLSATLTIPFWQWFLTRFGKKTAVY 359
Cdd:cd17392 232 LAGLKLVTGHPPYLKLVIGFLFSSLAFQMEQGNFVLFCTHAAGLGDHFQHLVLAILVSATLSIPLWQWVLQRRGKKTTSF 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 360 VGTTIVIPFLITVVLMKSNLIVTYVIAIASGVSIAAAFLLPWSMLPDVVDDFKVLNPESQGHEAIFYSFYVFFTKFASGV 439
Cdd:cd17392 312 IGISAMVPFLILLALVPSNLPVAYVVAVVSGVSLAALFLLPWSMLPDVVDDFQLKNPHCPGLEPIFYSCYVFFTKLGGGL 391
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 1832123188 440 SLGISTLSLDFAGYVTRGCTQPKAVDVTLKVLVSAAPVALIFIGLLIFTSYPINE 494
Cdd:cd17392 392 SLGISTLSLHFSGYKAGACKQPEEVVVTLKVLIAPVPICLILAGLVLFYVYPINE 446
|
|
| MFS_MFSD2B |
cd17452 |
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily ... |
41-494 |
0e+00 |
|
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily domain-containing protein 2B (MFSD2B) is closely related to MFSD2A, and their conserved genomic structure suggests that they are derived from the duplication of an ancestral gene. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer identified MFSD2B as a potential risk or protect factor in the prognosis of lung adenocarcinoma. MFSD2B belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341010 Cd Length: 416 Bit Score: 607.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 41 KLCYAVGGAPYQITGCALGFFLQIYLLDVALLDPFYASVILFVGRAWDAITDPTVGFLVSRTPWTRFGRMMPWIILSTPF 120
Cdd:cd17452 1 KLCYAIGGAPNQVAGSATAFFLQIYLLDIAQITPFQASLVLFVGKAWGAATDPVVGFFISKSKWTKIGRLMPWMLGCTPF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 121 AVMSYFLIWYVPPVDQTKVVWYLIFYCLFQTLQTCFHVPYSALTMFISSEQKERDSATAYRMTVEVLGTVIGTGIQGQIV 200
Cdd:cd17452 81 IVVSYFFLWFVPPFTTGRFLWYLTFYCLFQALATCFHVPYSALTMFLSTDQRERDSATAYRMTVEVLGTLVGAAVQGQIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 201 GmanapcipvgndlnatfrnsgseanitqpdlsldkvrNAYMIASGVICAIYVLCAITLFCGVKERKENSKVHSER-MSF 279
Cdd:cd17452 161 A-------------------------------------SAYMIAAGVIGGLYLLCISVLFLGVKERDDPYAPKSGKaIPF 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 280 FRGIRLVMGHGPYAKLVMGFLFTSLAFMLLEGNFALFCSYTLGFRDDFQNVLLVVMLSATLTIPFWQWFLTRFGKKTAvY 359
Cdd:cd17452 204 FKGLSLTMRHGPYLKLTASFLFISAAVQLEQSNFVLFCTHAVDLHDHFQNLVLTILVSAVVSIPFWQWFLQRFGKKAA-A 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 360 VGTTIVIPFLITVVLMkSNLIVTYVIAIASGVSIAAAFLLPWSMLPDVVDDFKVLNPESQGHEAIFYSFYVFFTKFASGV 439
Cdd:cd17452 283 CGISWMIPFAIMLVTI-PNLIVAYVVAFVSGLSIAASLLLPWSMLPDVVDDFRLQNPHGKGLETIFYSSYVFFTKLSAGI 361
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 1832123188 440 SLGISTLSLDFAGYVTRGCTQPKAVDVTLKVLVSAAPVALIFIGLLIFTSYPINE 494
Cdd:cd17452 362 ALGISTLSLEFAGYETGACKQPESVVLTLKLLIGAAPTCMILIGLCILMFYPITE 416
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
43-494 |
5.05e-113 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 357.00 E-value: 5.05e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 43 CYAVGGAPYQITGCALGFFLQIYLLDVALLDPFYASVILFVGRAWDAITDPTVGFLVSRTPwTRFGRMMPWIILSTPFAV 122
Cdd:pfam13347 1 GYGSGALAAGIKYAGLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTR-TRWGRRRPWLLLSAIILA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 123 MSYFLIWYVPPVDQ-TKVVWYLIFYCLFQTLQTCFHVPYSALTMFISSEQKERDSATAYRMTVEVLGTVIGTGIQGQIVG 201
Cdd:pfam13347 80 VSFILLFTPPELGRaPLFIWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 202 MANAPCIPvgndlnatfrnsgseanitqpdlsldkvRNAYMIASGVICAIYVLCAITLFCGVKE----RKENSKVHSERM 277
Cdd:pfam13347 160 ILGGTGLE----------------------------RKGYRIFALIGAVLMLLGVIITAAGTKErvsmRSKEDTGQKEAG 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 278 SFFRGIRLVMGHGPYAKLVMGFLFTSLAFMLLEGNFALFCSYTLGFRDDFQNVLLVVMLSATLTIPFWQWFLTRFGKKTA 357
Cdd:pfam13347 212 SLLDMLKEVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNT 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 358 VYVGTTIVIPFLITVVLM-KSNLIVTYVIAIASGVSIAAAFLLPWSMLPDVVDDFKVLNPESqgHEAIFYSFYVFFTKFA 436
Cdd:pfam13347 292 YILGALITIAGFALALLLgPNNTLLFLVLYIIIGFGYGSSFFLPWSMLADVVDYGELRTGKR--REGTFFAMWSFISKLA 369
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 1832123188 437 SGVSLGISTLSLDFAGYVTRGCTQPKAVDVTLKVLVSAAPVALIFIGLLIFTSYPINE 494
Cdd:pfam13347 370 TGVGLGVSGLLLSAFGYNAGDSVQSPQAVTAIRLLYAVLPAVLFLVALLLLYFYPLDR 427
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
41-494 |
1.13e-104 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 334.57 E-value: 1.13e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 41 KLCYAVGGAPYQITGCALGFFLQIYLLDVALLDPFYASVILFVGRAWDAITDPTVGFLVSRTPwTRFGRMMPWIILSTPF 120
Cdd:cd17332 1 KIGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTR-SRWGRFRPWLLWGAIP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 121 AVMSYFLIWYVPPVDQT-KVVWYLIFYCLFQTLQTCFHVPYSALTMFISSEQKERDSATAYRMTVEVLGTVIGTGIQGQI 199
Cdd:cd17332 80 LALLFVLLFTTPDGSGTgKLIYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 200 VGMANAPCIPVGndlnatfrnsgseanitqpdlsldkvrnaYMIASGVICAIYVLCAITLFCGVKERKENSKVHSERMSF 279
Cdd:cd17332 160 VAYFGGGNASRG-----------------------------YFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKLPL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 280 FRGIRLVMGHGPYAKLVMGFLFTSLAFMLLEGNFALFCSYTLGFRDDFQNVLLVVMLSATLTIPFWQWFLTRFGKKTAVY 359
Cdd:cd17332 211 LKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFF 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 360 VGTTIVIPF-LITVVLMKSNLIVTYVIAIASGVSIAAAFLLPWSMLPDVVDDFKVLNPesQGHEAIFYSFYVFFTKFASG 438
Cdd:cd17332 291 IGLLLAILGlLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLADVIDYGELKTG--KRREGIFYSVMTFFRKLGLA 368
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 1832123188 439 VSLGISTLSLDFAGYVTRGCTQPKAVDVTLKVLVSAAPVALIFIGLLIFTSYPINE 494
Cdd:cd17332 369 LAGALVGLILSLAGYVANAAAQSASALNGIRLLIAVLPAVLLLLALILMSFYPLDK 424
|
|
| PRK08560 |
PRK08560 |
tyrosyl-tRNA synthetase; Validated |
558-886 |
1.64e-95 |
|
tyrosyl-tRNA synthetase; Validated
Pssm-ID: 236286 [Multi-domain] Cd Length: 329 Bit Score: 306.79 E-value: 1.64e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 558 DKKFNLITRNLQEVLGEEKLK-LILMERELKVYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAFLDNmKAP 636
Cdd:PRK08560 2 EERLELITRNTEEVVTEEELReLLESKEEPKAYIGFEPSGKIHLGHLLTMNKLADLQKAGFKVTVLLADWHAYLND-KGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 637 WELLELRVKYYEQVIKAMlesiGVPLDKLKFVKGTEYQLSREYTLDVYRLSSMVTEHDAKKAGAEVVKQVEHPLLSGLLY 716
Cdd:PRK08560 81 LEEIRKVAEYNKKVFEAL----GLDPDKTEFVLGSEFQLDKEYWLLVLKLAKNTTLARARRSMTIMGRRMEEPDVSKLVY 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 717 PGLQALDEEYLKVDAQFGGVDQRKIFTLAEKYLPSLGYTKRIHMMNPMVPGLTGS--KMSSSEEESKIDLLDKKEDIKKK 794
Cdd:PRK08560 157 PLMQVADIFYLDVDIAVGGMDQRKIHMLAREVLPKLGYKKPVCIHTPLLTGLDGGgiKMSKSKPGSAIFVHDSPEEIRRK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 795 LKKAFCEPGNIQNNGVLSFVKHVLFPLHSEFAIKRDPKFGGDKVYTFYEELEKDFAEERIHPGDLKASVEVALDKLLDPI 874
Cdd:PRK08560 237 IKKAYCPPGEVEGNPVLEIAKYHIFPRYDPFVIERPEKYGGDLEYESYEELERDYAEGKLHPMDLKNAVAEYLIEILEPV 316
|
330
....*....|..
gi 1832123188 875 RKKFETPELKKL 886
Cdd:PRK08560 317 REYLEEGPELLE 328
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
30-509 |
4.90e-92 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 301.44 E-value: 4.90e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 30 SEEKRHLSVCNKLCYAVGGAPYQITGCALGFFLQIYLLDVALLDPFYASVILFVGRAWDAITDPTVGFLVSRTpWTRFGR 109
Cdd:COG2211 1 TAAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRT-RTRWGR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 110 MMPWIILSTPFAVMSYFLIWYVPPVDQT-KVVWYLIFYCLFQTLQTCFHVPYSALTMFISSEQKERDSATAYRMTVEVLG 188
Cdd:COG2211 80 RRPWILIGAIPLALSFVLLFTAPDLSPTgKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 189 TVIGTGIQGQIVGManapcipVGNDlnatfrnsgseanitqpdlsldkVRNAYMIASGVICAIYVLCAITLFCGVKERKE 268
Cdd:COG2211 160 GLLASVLPPPLVAA-------FGGD-----------------------AALGYRLTALIFAVLGLLAFLLTFFGTKERPV 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 269 NSKvhsERMSFFRGIRLVMGHGPYAKLVMGFLFTSLAFMLLEGNFALFCSYTLGFRDDFQNVLLVVM-LSATLTIPFWQW 347
Cdd:COG2211 210 PEE---EKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYfLAALLGAPLWPR 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 348 FLTRFGKKTAVYVGTTI-VIPFLITVVLMKSNLIVTYVIAIASGVSIAAAFLLPWSMLPDVVDDFKVLNPESQghEAIFY 426
Cdd:COG2211 287 LAKRFGKKKAFIIGLLLaALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRR--EGLYF 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 427 SFYVFFTKFASGVSLGISTLSLDFAGYVTrGCTQPKAVDVTLKVLVSAAPVALIFIGLLIFTSYPINEKRRQGNRKLLNE 506
Cdd:COG2211 365 GIFTFAIKLGQALAGALAGLLLALFGYVA-GAAQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAA 443
|
...
gi 1832123188 507 QRE 509
Cdd:COG2211 444 RRA 446
|
|
| TyrRS_core |
cd00805 |
catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) ... |
586-870 |
1.56e-79 |
|
catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) catalytic core domain. TyrRS is a homodimer which attaches Tyr to the appropriate tRNA. TyrRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formationof the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173902 [Multi-domain] Cd Length: 269 Bit Score: 261.00 E-value: 1.56e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 586 LKVYWGTATTG-KPHVAYFVPMSKIADFLKAGCEVTILFADLHAFLDNMK--------APWELLELRVKYYEQVIKAMLE 656
Cdd:cd00805 1 LKVYIGFDPTApSLHLGHLVPLMKLRDFQQAGHEVIVLIGDATAMIGDPSgkseerklLDLELIRENAKYYKKQLKAILD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 657 SIgvPLDKLKFVKGTEYQLSrEYTLDVYRLSSMVTEHDAKKAGAEVVKQ--VEHPLLSGLLYPGLQALDEEYLKVDAQFG 734
Cdd:cd00805 81 FI--PPEKAKFVNNSDWLLS-LYTLDFLRLGKHFTVNRMLRRDAVKVRLeeEEGISFSEFIYPLLQAYDFVYLDVDLQLG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 735 GVDQRKIFTLAEKYLPSLGYTKRIHMMNPMVPGLTGSKM-SSSEEESKIDLLDKKEDIKKKLKKAFCEPgniqnngVLSF 813
Cdd:cd00805 158 GSDQRGNITLGRDLIRKLGYKKVVGLTTPLLTGLDGGKMsKSEGNAIWDPVLDSPYDVYQKIRNAFDPD-------VLEF 230
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1832123188 814 VKHVLFPLHSEfaikrdpkfggdkvytfYEELEKDFAEErIHPGDLKASVEVALDKL 870
Cdd:cd00805 231 LKLFTFLDYEE-----------------IEELEEEHAEG-PLPRDAKKALAEELTKL 269
|
|
| tRNA-synt_1b |
pfam00579 |
tRNA synthetases class I (W and Y); |
583-871 |
1.33e-61 |
|
tRNA synthetases class I (W and Y);
Pssm-ID: 395461 [Multi-domain] Cd Length: 292 Bit Score: 212.14 E-value: 1.33e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 583 ERELKVYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAFL-DNMKAPWELLELRVKYYEQVIKAMLeSIGVP 661
Cdd:pfam00579 3 NRPLRVYSGIDPTGPLHLGYLVPLMKLRQFQQAGHEVFFLIGDLHAIIgDPSKSPERKLLSRETVLENAIKAQL-ACGLD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 662 LDKLKFVKGTEYQLSREYTLDVYRLSSMVTEHDAKKAGaEVVKQVEHP---LLSGLLYPGLQALDEEYLKVDAQFGGVDQ 738
Cdd:pfam00579 82 PEKAEIVNNSDWLEHLELAWLLRDLGKHFSLNRMLQFK-DVKKRLEQGpgiSLGEFTYPLLQAYDILLLKADLQPGGSDQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 739 RKIFTLAEKYLPSLGY---TKRIHMMNPMVPGLTG-SKMSSSEEESKIDLLDKKEDIKKKLKKAFCEPGNiqNNGVLSFV 814
Cdd:pfam00579 161 WGNIELGRDLARRFNKkifKKPVGLTNPLLTGLDGgKKMSKSAGNSAIFLDDDPESVYKKIQKAYTDPDR--EVRKDLKL 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1832123188 815 KHVLFPlhseFAIKRDPKFGGDKVYTFYEELEKDFAEERIHPGDLKASVEVALDKLL 871
Cdd:pfam00579 239 FTFLSN----EEIEILEAELGKSPYREAEELLAREVTGLVHGGDLKKAAAEAVNKLL 291
|
|
| PLN02610 |
PLN02610 |
probable methionyl-tRNA synthetase |
894-1076 |
2.91e-59 |
|
probable methionyl-tRNA synthetase
Pssm-ID: 215329 [Multi-domain] Cd Length: 801 Bit Score: 218.88 E-value: 2.91e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 894 KNKNAVKVNPKKAEEEdEIIPSRLDLRVGKIVGVEKHPAADTLYLEKIDIGEEQPRTVVSGLVAYVSQEELQDRLVVVLC 973
Cdd:PLN02610 621 GKKAGGGGKSKAAAER-EIDVSRLDIRVGLIVKAEKHPDADSLYVEEIDVGEGAPRTVVSGLVKYIPLEEMQNRKVCVLC 699
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 974 NLKPQKMRGIESQAMLLCASvDGEPKRVEPLDPPEGSAPGERVFVDGYtSGTPDDELKPKKKVFEKIQVDMKISDECIAQ 1053
Cdd:PLN02610 700 NLKPAAMRGIKSQAMVLAAS-NSDHTKVELVEPPESAAVGERVTFPGF-EGEPDDVLNPKKKVWETLQPDLHTNSELVAC 777
|
170 180
....*....|....*....|...
gi 1832123188 1054 WNKKDLITKLGKITCKTLKGGSI 1076
Cdd:PLN02610 778 YKDVPFTTSAGVCKVASIANGSI 800
|
|
| tRNA_bind_EMAP-II_like |
cd02799 |
tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of ... |
914-1017 |
3.28e-57 |
|
tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae Arc1p, human p43 and EMAP2. CeMetRS and hTyrRS aminoacylate their cognate tRNAs. Arc1p is a transactivator of yeast methionyl-tRNA and glutamyl-tRNA synthetases. This domain has general tRNA binding properties. In a subset of this family this domain has the added capability of a cytokine. For example the p43 component of the Human aminoacyl-tRNA synthetase complex is cleaved to release EMAP-II cytokine. EMAP-II has multiple activities during apoptosis, angiogenesis and inflammation and participates in malignant transformation. A EMAP-II-like cytokine also is released from hTyrRS upon cleavage. The active cytokine heptapeptide locates to this domain.
Pssm-ID: 239198 [Multi-domain] Cd Length: 105 Bit Score: 192.06 E-value: 3.28e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 914 PSRLDLRVGKIVGVEKHPAADTLYLEKIDIGEEQPRTVVSGLVAYVSQEELQDRLVVVLCNLKPQKMRGIESQAMLLCAS 993
Cdd:cd02799 3 PSRLDIRVGKILKVRKHPDADSLYVEEIDLGEEEPRTIVSGLVKFVPLEQMQNRLVVVLCNLKPRKMRGVKSQGMVLCAS 82
|
90 100
....*....|....*....|....
gi 1832123188 994 VDGEPKrVEPLDPPEGSAPGERVF 1017
Cdd:cd02799 83 NADHEK-VELLEPPEGAKPGERVT 105
|
|
| tyrS |
TIGR00234 |
tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up ... |
557-879 |
6.05e-49 |
|
tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up tryptophanyl-tRNA synthetases at scores of 0 and below. The proteins found by this model have a deep split between two groups. One group contains bacterial and organellar eukaryotic examples. The other contains archaeal and cytosolic eukaryotic examples. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 272976 [Multi-domain] Cd Length: 378 Bit Score: 178.74 E-value: 6.05e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 557 PDKKFNLITRNLQEVLGEEKLKLI--LMERELKVYWGTATTG-KPHVAYFVPMSKIADFLKAGCEVTILFADLHAFLDNM 633
Cdd:TIGR00234 1 MNNILLLLTKRGLEVQTPEEEKDLlkLLERPLKLYLGFDPTApSLHLGHLVPLLKLRDFQQAGHEVIVLLGDFTALIGDP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 634 KAPWELLELR-----VKYYEQVIKAMLESIGVplDKLKFVKGTEYQLSREYTLDVYRLSSMVTEHDAKKAGAEVVKQVEH 708
Cdd:TIGR00234 81 TGKSEVRKILtreevQENAENIKKQIARFLDF--EKAKFVYNSEWLLKLNYTDFIRLLGKIFTVNRMLRRDAFSSRFEEN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 709 PLLSGLLYPGLQALDEEYLKVDAQFGGVDQ----RKIFTLAEKYLPSLGYTKRIHMMNP---MVPGLTGS-KMSS--SEE 778
Cdd:TIGR00234 159 ISLHEFIYPLLQAYDFVYLNVDLQLGGSDQwfniRKGRDLARENLPSLQFGLTVPLLTPadgEKMGKSLGgAVSLdeGKY 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 779 ESKIDLLDKKEDIKKKLKKAFCEPGN----------------IQNNGVLSFVKHVLFP------------------LHSE 824
Cdd:TIGR00234 239 DFYQKVINTPDELVKKYLKLFTFLGLeeieqlvelkgpnpreVKENLALEITKYVHGPeaalaaeeiseaifsgglNPDE 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1832123188 825 FAIKRDPKFGGDKVYTFYEELEKDFAEERIHPGDLK-ASVEVA--LDKLLDPIRKKFE 879
Cdd:TIGR00234 319 VPIFRPEKFGGPITLADLLVLSGLFPSKSEARRDIKnGGVYINgeKVEDLEPIRKELE 376
|
|
| gph |
TIGR00792 |
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ... |
41-496 |
1.98e-44 |
|
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273270 Cd Length: 437 Bit Score: 167.04 E-value: 1.98e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 41 KLCYAVGGAPYQITGCALGFFLQIYLLDVALLDPFYASVILFVGRAWDAITDPTVGFLVSRTPwTRFGRMMPWI-ILSTP 119
Cdd:TIGR00792 1 KLSYGFGDFGNDFIFAIVSTYLLFFYTDVLGLSAAFVGTLFLVARILDAITDPIMGNIVDRTR-TRWGKFRPWLlIGAIP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 120 FAVMSyFLIWYVPPVDQT-KVVWYLIFYCLFQTLQTCFHVPYSALTMFISSEQKERDSATAYRMtvevlgtvIGTGIQGQ 198
Cdd:TIGR00792 80 FSIVL-VLLFTTPDFSGTgKLVYAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRR--------FGATLGGL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 199 IVGMAnapCIPVGNDLNATFRNSGseanitqpdlsldkvrnaYMIASGVICAIYVLCAITLFCGVKERKENSKVHSERMS 278
Cdd:TIGR00792 151 LVAVI---VLPLVSYFGGGDDKFG------------------WFMFALVLALIGVVSLIICFFGTKERYSEIPKNIEKKL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 279 FFRGI-RLVMGHGPYAKLVMGFLFTSLAFMLLEGNFALFCSYTLGFRDDFQNVLLVVMLSATLTIPFWQWFLTRFGKKTA 357
Cdd:TIGR00792 210 SLKQIfKALFKNDQLLILCLAYLFYNLAFNIKNGVQVYYFTYVLGDPELFSYMGSIAIVAGLIGVLLFPRLVKKFGRKIL 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 358 VYVGTTIVIPFLITVVLMKSNLIVTYVIAIASGVSIAAAFLLPWSMLPDVVDDFKVLNpesqGH--EAIFYSFYVFFTKF 435
Cdd:TIGR00792 290 FAGGILLMVLGYLIFFFAGSNLPLILVLIILAGFGQNIVTGLVWALVADTVDYGEWKT----GIraEGLVYSVRTFVRKL 365
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1832123188 436 ASGVSLGISTLSLDFAGYVTrGCTQPKAVDVTLKVLVSAAPVALIFIGLLIFTS-YPINEKR 496
Cdd:TIGR00792 366 GQALAGFFVGLILGIIGYVA-NAAQSPITLNGIKILMFAVPALFLLLAAIIIGRfYKLTEKK 426
|
|
| PTZ00126 |
PTZ00126 |
tyrosyl-tRNA synthetase; Provisional |
552-889 |
2.63e-44 |
|
tyrosyl-tRNA synthetase; Provisional
Pssm-ID: 240282 [Multi-domain] Cd Length: 383 Bit Score: 165.25 E-value: 2.63e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 552 GEEMSPDKKFNLITRNLQEVLGEEKL-KLILMERELKVYWGTATTGKPHVAYFVPMSKIADFL-KAGCEVTILFADLHAF 629
Cdd:PTZ00126 32 QSKLSLEERVKLCLSIGEECIQPEELrELLKLKERPICYDGFEPSGRMHIAQGILKAINVNKLtKAGCVFVFWVADWFAL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 630 LDNmKAPWELLELRV--KYYEQVIKAmlesIGVPLDKLKFVKGTEY--QLSREYTLDVYRLSSMVTEHDAKKAGAEVVKQ 705
Cdd:PTZ00126 112 LNN-KMGGDLEKIRKvgEYFIEVWKA----AGMDMDNVRFLWASEEinKNPNDYWLRVMDIARSFNITRIKRCSQIMGRS 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 706 V--EHPLlSGLLYPGLQALDEEYLKVDAQFGGVDQRKIFTLAEKY--LPSLGYtKRIHMMNPMVPGLT--GSKMSSSEEE 779
Cdd:PTZ00126 187 EgdEQPC-AQILYPCMQCADIFYLKADICQLGMDQRKVNMLAREYcdKKKIKK-KPIILSHHMLPGLLegQEKMSKSDPN 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 780 SKIDLLDKKEDIKKKLKKAFCEPGNIQNNGVLSFVKHVLFPLHSEFAIKRDPKFGGDKVYTFYEELEKDFAEERIHPGDL 859
Cdd:PTZ00126 265 SAIFMEDSEEDVNRKIKKAYCPPGVIEGNPILAYFKSIVFPAFNSFTVLRKEKNGGDVTYTTYEELEKDYLSGALHPGDL 344
|
330 340 350
....*....|....*....|....*....|.
gi 1832123188 860 KASVEVALDKLLDPIRKKFET-PELKKLTSL 889
Cdd:PTZ00126 345 KPALAKYLNLMLQPVRDHFQNnPEAKSLLSE 375
|
|
| tRNA_bindingDomain |
cd02153 |
The tRNA binding domain is also known as the Myf domain in literature. This domain is found in ... |
919-1016 |
7.92e-37 |
|
The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human tyrosyl-tRNA synthetase(hTyrRS), Saccharomyces cerevisiae Arc1p, Thermus thermophilus CsaA, Aquifex aeolicus Trbp111, human p43 and human EMAP-II. PheRS, MetRS and hTyrRS aminoacylate their cognate tRNAs. Arc1p is a transactivator of yeast methionyl-tRNA and glutamyl-tRNA synthetases. The molecular chaperones Trbp111 and CsaA also contain this domain. CsaA has export related activities; Trbp111 is structure-specific recognizing the L-shape of the tRNA fold. This domain has general tRNA binding properties. In a subset of this family this domain has the added capability of a cytokine. For example the p43 component of the Human aminoacyl-tRNA synthetase complex is cleaved to release EMAP-II cytokine. EMAP-II has multiple activities during apoptosis, angiogenesis and inflammation and participates in malignant transformation. An EMAP-II-like cytokine is released from hTyrRS upon cleavage. The active cytokine heptapeptide locates to this domain. For homodimeric members of this group which include CsaA, Trbp111 and Escherichia coli MetRS this domain acts as a dimerization domain.
Pssm-ID: 239066 [Multi-domain] Cd Length: 99 Bit Score: 133.80 E-value: 7.92e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 919 LRVGKIVGVEKHPAADTLYLEKIDIGEEQPRTVVSGLVAYVSQEELQDRLVVVLCNLKPQKMRGIESQAMLLCASVDG-E 997
Cdd:cd02153 1 LRVGKIVEAEPHPNADKLYVLKVDIGEEKPRQIVSGAANVYPPEELVGKKVVVAVNLKPKKLRGVESEGMLLSAEELGlE 80
|
90
....*....|....*....
gi 1832123188 998 PKRVEPLDPPEGSAPGERV 1016
Cdd:cd02153 81 EGSVGILELPEDAPVGDRI 99
|
|
| tRNA_bind |
pfam01588 |
Putative tRNA binding domain; This domain is found in prokaryotic methionyl-tRNA synthetases, ... |
919-1015 |
6.01e-36 |
|
Putative tRNA binding domain; This domain is found in prokaryotic methionyl-tRNA synthetases, prokaryotic phenylalanyl tRNA synthetases the yeast GU4 nucleic-binding protein (G4p1 or p42, ARC1), human tyrosyl-tRNA synthetase, and endothelial-monocyte activating polypeptide II. G4p1 binds specifically to tRNA form a complex with methionyl-tRNA synthetases. In human tyrosyl-tRNA synthetase this domain may direct tRNA to the active site of the enzyme. This domain may perform a common function in tRNA aminoacylation.
Pssm-ID: 396251 [Multi-domain] Cd Length: 96 Bit Score: 131.21 E-value: 6.01e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 919 LRVGKIVGVEKHPAADTLYLEKIDIGEEQPRTVVSGLVAYVSQEELQDRLVVVLCNLKPQKMRGIESQAMLLCASvDGEP 998
Cdd:pfam01588 1 LRVGKVVEAERHPNADKLLVCKVDVGEEEPRQIVSGAVNVYPPEELVGRLVVVVANLKPAKLRGVESEGMILSAE-ELDG 79
|
90
....*....|....*..
gi 1832123188 999 KRVEPLDPPEGSAPGER 1015
Cdd:pfam01588 80 GSVGLLEPPADVPPGTK 96
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
844-1010 |
2.86e-29 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 124.91 E-value: 2.86e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 844 ELEKDFAEERIHPGDLKASVEVALDKLLDP-IRKKFETPELKKLtslayPSKNKNAVKVNPKKAEEEDEI-IP--SRLDL 919
Cdd:PRK12267 479 EEELTSWESLLEWGGLPAGTKVAKGEPLFPrIDVEEEIAYIKEQ-----MEGSAPKEPEEKEKKPEKPEItIDdfDKVEL 553
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 920 RVGKIVGVEKHPAADTLYLEKIDIGEEQPRTVVSGLVAYVSQEELQDRLVVVLCNLKPQKMRGIESQAMLLCASVDGEPK 999
Cdd:PRK12267 554 RVAEVLEAEKVEKSDKLLKLQVDLGEEEPRQIVSGIAKFYPPEELVGKKVVVVANLKPAKLMGEESQGMILAAEDDGKLT 633
|
170
....*....|..
gi 1832123188 1000 RVEPLDP-PEGS 1010
Cdd:PRK12267 634 LLTVDKEvPNGS 645
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
883-1016 |
6.85e-28 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 121.03 E-value: 6.85e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 883 LKKLTSLAYPSKNKNAVKVNPKKAEEEDEI-IP--SRLDLRVGKIVGVEKHPAADTLYLEKIDIGEEQpRTVVSGLVAYV 959
Cdd:PRK00133 539 IEASKEAAAAKAAAAAAAAPLAEEPIAETIsFDdfAKVDLRVAKIVEAEKVEGADKLLKLTLDLGEET-RQVFSGIKSAY 617
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1832123188 960 SQEELQDRLVVVLCNLKPQKMRGIESQAMLLCASVDGEpkRVEPLDPPEGSAPGERV 1016
Cdd:PRK00133 618 DPEELVGKLVVMVANLAPRKMKFGVSEGMVLAAGPGGG--DLFLLEPDEGAKPGMRV 672
|
|
| tRNA_bind_EcMetRS_like |
cd02800 |
tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like ... |
915-1016 |
7.38e-28 |
|
tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine transfer RNAs (tRNAmet). AaTrbp111 is structure-specific molecular chaperone recognizing the L-shape of the tRNA fold. AaTrbp111 plays a role in nuclear trafficking of tRNAs. The functional unit of EcMetRs and AaTrbp111 is a homodimer, this domain acts as the dimerization domain.
Pssm-ID: 239199 [Multi-domain] Cd Length: 105 Bit Score: 108.36 E-value: 7.38e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 915 SRLDLRVGKIVGVEKHPAADTLYLEKIDIGEEqPRTVVSGLVAYVSQEELQDRLVVVLCNLKPQKMRGIESQAMLLCASV 994
Cdd:cd02800 7 AKVDLRVGKVLEAERVEGSDKLLKLTVDLGEE-ERQIVSGIAKFYPPEELVGKKVVVVANLKPRKLRGVESQGMILAAED 85
|
90 100
....*....|....*....|..
gi 1832123188 995 DGEPKRvepLDPPEGSAPGERV 1016
Cdd:cd02800 86 GGKLKL---LTPDEEVEPGSRV 104
|
|
| tRNA_bind_CsaA |
cd02798 |
tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export ... |
916-1016 |
1.75e-25 |
|
tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain.
Pssm-ID: 239197 [Multi-domain] Cd Length: 107 Bit Score: 101.93 E-value: 1.75e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 916 RLDLRVGKIVGVEKHP-AADTLYLEKIDIGEEQPRTVVSGLVAYVSQEELQDRLVVVLCNLKPQKMRGIESQAMLLCAsv 994
Cdd:cd02798 8 KVDLRVGTIVEVEDFPeARKPAYKLKVDFGEIGVKQSSAQITKYYKPEELIGRQVVAVVNFPPKQIAGVLSEVLVLGA-- 85
|
90 100
....*....|....*....|..
gi 1832123188 995 DGEPKRVEPLDPPEGSAPGERV 1016
Cdd:cd02798 86 DDEGGEVVLLVPDREVPNGAKV 107
|
|
| metG_C_term |
TIGR00399 |
methionyl-tRNA synthetase C-terminal region/beta chain; The methionyl-tRNA synthetase (metG) ... |
884-1016 |
3.20e-25 |
|
methionyl-tRNA synthetase C-terminal region/beta chain; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model describes a region of the methionyl-tRNA synthetase that is present at the C-terminus of MetG in some species (E. coli, B. subtilis, Thermotoga maritima, Methanobacterium thermoautotrophicum), and as a separate beta chain in Aquifex aeolicus. It is absent in a number of other species (e.g. Mycoplasma genitalium, Mycobacterium tuberculosis), while Pyrococcus horikoshii has both a full length MetG and a second protein homologous to the beta chain only. Proteins hit by this model should be called methionyl-tRNA synthetase beta chain if and only if the model metG hits a separate protein not also hit by this model. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273059 [Multi-domain] Cd Length: 137 Bit Score: 102.12 E-value: 3.20e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 884 KKLTSLAYPSKNKNAVKVNPKKAEEEDEIIPS-----RLDLRVGKIVGVEKHPAADTLYLEKIDIGEEQpRTVVSGLVAY 958
Cdd:TIGR00399 2 KKIEELKLKGAKKKEKKDEGEKALEPQKETITiddfeKVDLRVGKILKAERVEKSDKLLKLKLDLGDEK-RQIVSGIAGY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1832123188 959 VSQEELQDRLVVVLCNLKPQKMRGIESQAMLLCASVDGepKRVEPLDPPEGSAPGERV 1016
Cdd:TIGR00399 81 YTPEELVGKKVIVVANLKPAKLFGVKSEGMILAAEDDG--KVLFLLSPDQEAIAGERI 136
|
|
| PRK09669 |
PRK09669 |
putative symporter YagG; Provisional |
36-496 |
4.65e-25 |
|
putative symporter YagG; Provisional
Pssm-ID: 236610 Cd Length: 444 Bit Score: 109.81 E-value: 4.65e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 36 LSVCNKLCYAVGGapyqiTGCAL-----GFFLQIYLLDVALLDPFYASVILFVGRAWDAITDPTVGFLVSRTPwTRFGRM 110
Cdd:PRK09669 6 LTTKDKIGYGLGD-----TACNLvwqtvMLFLAYFYTDVFGLSAAIMGTMFLVVRVLDAVTDPLMGALVDRTR-TRHGQF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 111 MPWII-LSTPFAVmSYFLIWYVPPVDQT-KVVWYLIFYCLFQTLQTCFHVPYSALTMFISSEQKERDSATAYRMTVEVLG 188
Cdd:PRK09669 80 RPYLLwFAIPFGV-VCLLTFYTPDFGATgKIIYACVTYILLSLVYTAINVPYCAMPGAITNDPRERHSLQSWRFALSFIG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 189 tvigtgiqGQIVGMANAPCIPVgndlnatfrnsgseanITQPDlsldkVRNAYMIASGVICAIYVLCAITLFCGVKERKE 268
Cdd:PRK09669 159 --------GLIVSVIALPLVDI----------------LGKGD-----EQKGYFYAMMVMGLLGVVLFFCCFFMTKERYT 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 269 NSKVHSErmSFFRGIRLVMGHGPYaKLVMGFLFTSLAFMLLEGNFAL-FCSYTLGfRDDFQNVLLVVMLSATLTIPFWQW 347
Cdd:PRK09669 210 PEVDNSS--SVWKDLKLLLGNSQW-RIMFIFNVVLLTAVVTRGGATLyYVNYVLL-RPDLATLFLVTGMIAGLFGALLSE 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 348 FLtrFGKKTAVYVGTTIVIPFLITVVLM----KSNLIVTYVIAIASGVSIAAAFLLPWSMLPDVVDdfkVLNPES-QGHE 422
Cdd:PRK09669 286 RL--LGKFDRVRAFKWTIVAFVILSALIffipPSNVWLIFALNILFNFIQNLTTPLQWSMFSDVVD---YEEKRSgRRLD 360
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1832123188 423 AIFYSFYVFFTKFasGVSLGISTL--SLDFAGYVTRGCTQPKAVDVTLKVLVSAAPVALIFIGLLIFTSYPINEKR 496
Cdd:PRK09669 361 GLVFSTNLFAIKL--GLAIGGAVVgwILAWVDYVGGAAVQSASVLTTINLLFTVIPGVLFAGMAIILNFYKLNDAR 434
|
|
| PRK10429 |
PRK10429 |
melibiose:sodium transporter MelB; |
34-527 |
1.01e-20 |
|
melibiose:sodium transporter MelB;
Pssm-ID: 182453 Cd Length: 473 Bit Score: 96.70 E-value: 1.01e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 34 RHLSVCNKLCYAVGGAPYQITGCALGFFLQIYLLDVALLDPFYASVILFVGRAWDAITDPTVGFLVSRTPwTRFGRMMPW 113
Cdd:PRK10429 1 MSISMTTKLSYGFGAFGKDFAIGIVYMYLMYYYTDVVGLSVGLVGTLFLVARIWDAINDPIMGWIVNNTR-SRWGKFKPW 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 114 IILST---PFAVMSYFLIWYVPpvDQTKVVWYLIFYCLFQTLQTCFHVPYSALTMFISSEQKERDSATAYRMTVEVLGTV 190
Cdd:PRK10429 80 ILIGTlanSVVLFLLFSAHLFE--GTAQYVFVCVTYILWGMTYTIMDIPFWSLVPTLTLDKREREQLVPYPRFFASLAGF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 191 IGTGIQGQIVGManapcipVGNDlnatFRNSGseanitqpdlsldkvrnaYMIASGVICAIYVLCAITLFCGVKER---K 267
Cdd:PRK10429 158 VTAGFTLPFVNY-------VGGG----DRGFG------------------FQMFTLVLIAFFIVSTIITLRNVHEVyssD 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 268 ENSKVHSERMSFFRGIRLVMGHGPYAKLVMGFLFTSLAFMLLEGNFALFCSYTLGFRDDFQNVLLVVMLSATLTIPFWQW 347
Cdd:PRK10429 209 NQVSAEGSHLTLKDIVALIYKNDQLSCLLGMALAYNIASNIINGFAIYYFTYVIGDADLFPYYLSYAGAANLVTLILFPR 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 348 FLTRFGKKTaVYVGTTIViPFLITVVLMKSNLIVTYVIAIasgVSIAAAFL-----LPWS----MLPDVVD--DFKVlnp 416
Cdd:PRK10429 289 LVKSLSRRI-LWAGASIF-PVLSCGVLLLMGLAAPHNALL---IVIAGILLnigtaLFWVlqviMVADTVDygEYKL--- 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 417 eSQGHEAIFYSFYVFFTKFASGVSLGISTLSLDFAGYVTrGCTQPKAVDVTLKVLVSAAPVALIFIGLLI-FTSYPINE- 494
Cdd:PRK10429 361 -GIRCESIAYSVQTMVVKGGSAFAAFFIGVVLGLIGYVP-NVEQSAQTLLGMQFIMIGLPTLFFMITLVLyFRYYRLNGd 438
|
490 500 510
....*....|....*....|....*....|...
gi 1832123188 495 KRRQGNRKLLNEQRELESPADSSETELVNTGSV 527
Cdd:PRK10429 439 FLRRIQIHLLDKYRKVPPEPVHAEIPVGAVSDV 471
|
|
| EMAP |
COG0073 |
tRNA-binding EMAP/Myf domain [Translation, ribosomal structure and biogenesis]; |
907-1013 |
5.75e-19 |
|
tRNA-binding EMAP/Myf domain [Translation, ribosomal structure and biogenesis];
Pssm-ID: 439843 [Multi-domain] Cd Length: 773 Bit Score: 92.61 E-value: 5.75e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 907 EEEDEIIPSRLD-LRVGKIVGVEKHPAADTLYLEKIDIGEEqPRTVVSGL-VAYVSQ---EELQDRLVVVLCNLKPQKMR 981
Cdd:COG0073 31 EVEDFEKVGGLDgLRVGKVLEAEPHPNADKLLVLQVDVGEE-TRQIVCGApNVYAGDkvpEALVGAQVPGVVNLKPRKIR 109
|
90 100 110
....*....|....*....|....*....|...
gi 1832123188 982 GIESQAMLLCASVDGEPKRVE-PLDPPEGSAPG 1013
Cdd:COG0073 110 GVESEGMLCSAEELGLGEDHDgILELPEDAPPG 142
|
|
| PRK09848 |
PRK09848 |
glucuronide transporter; Provisional |
61-496 |
3.67e-17 |
|
glucuronide transporter; Provisional
Pssm-ID: 182109 [Multi-domain] Cd Length: 448 Bit Score: 85.61 E-value: 3.67e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 61 FLQIYLLDVALLDPFYASVILFVGRAWDAITDPTVGFLVSRTPwTRFGRMMPWIIL-STPFAVMSYFLIWYVPPVDQT-K 138
Cdd:PRK09848 30 FLLSYYTDVAGVGAAAAGTMLLLVRVFDAFADVFAGRVVDSVN-TRWGKFRPFLLFgTAPLMIFSVLVFWVPTDWSHSsK 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 139 VVWYLIFYCLFQTLQTCFHVPYSALTMFISSEQKERDSATAYRMtvevlgtvIGTGIQGQIVGMANAPCIpvgndlnatf 218
Cdd:PRK09848 109 VVYAYLTYMGLGLCYSLVNIPYGSLATAMTQQPQSRARLGAARG--------IAASLTFVCLAFLIGPSI---------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 219 rNSGSEANitqpdlsLDKVRNAYMIASGVI-CAIYVLCaitlfcgVKERKENSKVHSERMSFFRGIRLVMGHGPYAKLVM 297
Cdd:PRK09848 171 -KNSSPEE-------MVSVYHFWTIVLAIAgMVLYFIC-------FKSTRENVVRIVAQPSLKISLQTLKRNRPLFMLCI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 298 GflftslAFMLLEGNFAL------FCSYTLGFRDDFQNVLLVVMLSATL-TIPFWQWFLTRFGKKTAVYVGTTI-VIPFL 369
Cdd:PRK09848 236 G------ALCVLISTFAVsasslfYVRYVLNDTGLFTVLVLVQNLVGTVaSAPLVPGMVARIGKKNTFLIGALLgTCGYL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 370 ITVVLMKSNLIVTYVIAIASGVSIAAAFLLPWSMLPDVVDDFKVLNPESQghEAIFYSFYVFFTKFASGVSLGISTLSLD 449
Cdd:PRK09848 310 LFFWVSVWSLPVALVALAIASIGQGVTMTVMWALEADTVEYGEYLTGVRI--EGLTYSLFSFTRKCGQAIGGSIPAFILG 387
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 1832123188 450 FAGYVTRGCTQPKAVdVTLKVLVSAAPVALIFIGLLIFTSYPINEKR 496
Cdd:PRK09848 388 LSGYIANQVQTPEVI-MGIRTSIALVPCGFMLLAFVIIWFYPLTDKK 433
|
|
| PRK10089 |
PRK10089 |
chaperone CsaA; |
916-1017 |
2.03e-16 |
|
chaperone CsaA;
Pssm-ID: 182232 [Multi-domain] Cd Length: 112 Bit Score: 76.02 E-value: 2.03e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 916 RLDLRVGKIVGVEKHPAADTL-YLEKIDIGEE-QPRTVVSGLVAYVSQEELQDRLVVVLCNLKPQKMRGIESQAMLLCAS 993
Cdd:PRK10089 11 KVDIRVGTIVEAEPFPEARKPaYKLWIDFGEEiGVKQSSAQITPHYTPEELIGKQVVAVVNFPPKQIAGFMSEVLVLGFE 90
|
90 100
....*....|....*....|....
gi 1832123188 994 vdGEPKRVEPLDPPEGSAPGERVF 1017
Cdd:PRK10089 91 --DEDGEVVLLTPDRPVPNGVKLV 112
|
|
| MFS_MFSD12 |
cd17491 |
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily ... |
41-491 |
4.57e-13 |
|
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily domain-containing protein 12 (MFSD12) protein subfamily includes a group of uncharacterized proteins similar to human MFSD2. MFSD2 is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD12 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341044 Cd Length: 438 Bit Score: 72.68 E-value: 4.57e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 41 KLCYAVGGapYQITGCA-LGF-FLQIYLLDVALLDPFYASVILFVGRAWDAITDPTVGFLVSRTPW-TRFGRMMPWIILS 117
Cdd:cd17491 1 RIAYGVGH--VLNDLCAsMWFtYLLVYFHLVLGFSSALAGILLLIGQVADAISTPLVGYESDRTNGcGKYGRRKSWHLIG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 118 TPFAVMSYFLIWYVPP-----VDQT-KVVWYLIFYCLFQTLQTCFHVPYSALTMFISSEQKERDSATAYR--MTVevlgt 189
Cdd:cd17491 79 TICVLLSFPFIFNPCLgcsdsTSEWaKLVYYGPFIIIFQFGWAAVQISHLSLIPELTSDEHERVELTALRyaFTV----- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 190 vigtgiqgqivgMANapcIPVGNDLNATFRNSGSEANITQPDLSLDKVRNAYMIASGvicaIYVLCAITLFCGVKERKEN 269
Cdd:cd17491 154 ------------IAN---ITVYLIAWLLLQQSSGDSVNPTSAQDLPIFRNLSLIVVG----IGFLFSLLFHLGTKEPRPP 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 270 SKVHSERMSFFRGIRlvmghGPYAKLV-------MGFLFTSLAFML--LEGN-----FALFCSYTLGFRDDFQNVL-LVV 334
Cdd:cd17491 215 TDLSTTTNEGEEVTA-----PEEPRLTwkewlrePQFYQVALLYMCtrLIVNlsqvyIPLYLTETLQLPKESIAIVpLVM 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 335 MLSATLTiPFWQWFLTRF-GKKTAVYVGTTIVIPFLITVVLMKSNLIVTYVIAIASGVSIAAAFLL--PWSMLPDVVDDF 411
Cdd:cd17491 290 YVSGFLT-SLVMKPINKKiGRKITYLLGLLFVLGFCIWVWFQSGSSRTYEIYGAAVLLGVGSATLLvtSLSMTADLIGTN 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 412 KvlnpESqghEAIFYSFYVFFTKFASGVS-LGISTLsldfagyVTRGCTQPKAVDVTLKVLVSAAPVALIFIGLLIFTSY 490
Cdd:cd17491 369 T----ES---GAFVYGAMSFTDKLSNGIAvLIIQSL-------HPCNTELDECISYYYRVMVVVAGGVAILAGLLLLAFL 434
|
.
gi 1832123188 491 P 491
Cdd:cd17491 435 L 435
|
|
| PRK11462 |
PRK11462 |
putative transporter; Provisional |
36-193 |
2.86e-12 |
|
putative transporter; Provisional
Pssm-ID: 183145 Cd Length: 460 Bit Score: 70.35 E-value: 2.86e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 36 LSVCNKLCYAVGGAPYQITGCALGFFLQIYLLDVALLDPFYASVILFVGRAWDAITDPTVGFLVSRTPwTRFGRMMPWII 115
Cdd:PRK11462 6 LSVKEKIGYGMGDAASHIIFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTR-SRWGKFRPWVL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 116 L-STPFAVMSyFLIWYVPPVDQT-KVVWYLIFYCLFQTLQTCFHVPYSALTMFISSEQKERDSATAYRMTVEVLGTVIGT 193
Cdd:PRK11462 85 FgALPFGIVC-VLAYSTPDLSMNgKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRFVLATAGGMLST 163
|
|
| PTZ00348 |
PTZ00348 |
tyrosyl-tRNA synthetase; Provisional |
555-886 |
3.72e-12 |
|
tyrosyl-tRNA synthetase; Provisional
Pssm-ID: 173541 [Multi-domain] Cd Length: 682 Bit Score: 70.70 E-value: 3.72e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 555 MSPDKKFNLITRNLQEVLGEEKLK-LILMERELKVYWGTATTGKPHVAYFVPMS-KIADFLKAGCEVTILFADLHAFLdN 632
Cdd:PTZ00348 1 MNTDERYKLLRSVGEECIQESELRnLIEKKPLIRCYDGFEPSGRMHIAQGIFKAvNVNKCTQAGCEFVFWVADWFALM-N 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 633 MKAPWELLELRV--KYYEQVIKAMlesiGVPLDKLKFVKGTEYQLSREYT-----LDVYRLSSMVTehdAKKAGAEVVKQ 705
Cdd:PTZ00348 80 DKVGGELEKIRIvgRYLIEVWKAA----GMDMDKVLFLWSSEEITNHANTywrtvLDIGRQNTIAR---IKKCCTIMGKT 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 706 VEHPLLSGLLYPGLQALDEEYLKVDAQFGGVDQRKIFTLAEKYLPSLGYT-KRIHMMNPMVPGLTG--SKMSSSEEESKI 782
Cdd:PTZ00348 153 EGTLTAAQVLYPLMQCADIFFLKADICQLGLDQRKVNMLAREYCDLIGRKlKPVILSHHMLAGLKQgqAKMSKSDPDSAI 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 783 DLLDKKEDIKKKLKKAFCePGNIQN----------------NGVLSFVKHVLFPLHSEFAIKrdpkfgGDKVYTFYEELE 846
Cdd:PTZ00348 233 FMEDTEEDVARKIRQAYC-PRVKQSaseitddgapvatddrNPVLDYFQCVVYARPGAVATI------DGTTYATYEDLE 305
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1832123188 847 KDFAEERIHPGDLKASVEVALDKLLDPIRKKF-ETPELKKL 886
Cdd:PTZ00348 306 QAFVSDEVSEEALKSCLIDEVNALLEPVRQHFaSNPEAHEL 346
|
|
| tRNA_bind_bactPheRS |
cd02796 |
tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. ... |
919-989 |
4.22e-10 |
|
tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate the 2'OH of the terminal ribose of tRNA they belong functionally to class 1 aaRSs. This domain has general tRNA binding properties and is believed to direct tRNAphe to the active site of the enzyme.
Pssm-ID: 239196 [Multi-domain] Cd Length: 103 Bit Score: 57.90 E-value: 4.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 919 LRVGKIVGVEKHPAADTLYLEKIDIGEEQPRTVVSGlvayvSQEELQDRLVVV---------LCNLKPQKMRGIESQAML 989
Cdd:cd02796 1 VVVGKVLEVEPHPNADKLNVCKVDIGENKPLQIVCG-----APNVRAGDKVVValpgavlpgGLKIKKRKLRGVESEGML 75
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
42-430 |
9.96e-10 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 61.87 E-value: 9.96e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 42 LCYAVGGApyqitgcalgfFLQIYLLDVaLLDPFYASVILFVGRAWDAITDPTVGFLVSRTpWTRFGRMMPWIILSTPFA 121
Cdd:cd17313 13 FGWALENS-----------YVPPILQTL-GLSHALIGFVWTLGPILGLFVQPLVGSLSDRC-NSRIGRRRPFILVGAPLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 122 VMSYFLI----WYVPPVDQTKVVWYLIFYCLFQTL-----QTCFHvPYSALTMFI-SSEQKERDSATAYRMTveVLGTVI 191
Cdd:cd17313 80 ALGLILIpnaaDIGLALGDGPRTWALVLFVLGIVLldfamNVCQG-PVRALLPDLvPPEQRSKANGIINFMG--GLGGVL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 192 GTGIQGqivgmanapcipVGNDLNATFRNSGSEanitqpdlsldkVRNAYMIASgvicAIYVLCAITLFCGVKER--KEN 269
Cdd:cd17313 157 GYLLGA------------ILWDHNWFGFALGGN------------LKVPFYIGA----IILLVCVLVTLFFVKEPplSPE 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 270 SKVHSERMS---FFRGIRLVMGHGPYA--KLVMGFLFTSLAFMLLEGNFALFC-------------SYTLGFRdDFQNVL 331
Cdd:cd17313 209 AGEHSENPSlgeVLKSLLKLLKIMPRSllRLLLVIFFWWIAFFPFELFFTDYMgeevyhgtsaassHYGAGVR-MGAWGL 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 332 LVVMLSATLTIPFWQWFLTRFGKKtAVYVGTTIVIPFLITVVLMKSNLIVTYVIAIASGVSIAAAFLLPWSMLPDVVDDf 411
Cdd:cd17313 288 LIFSLAFLIFSLPIGKLGKKIGRK-KVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSE- 365
|
410 420
....*....|....*....|
gi 1832123188 412 kvlNPESQG-HEAIFYSFYV 430
Cdd:cd17313 366 ---SGRGQGtDTGLLNLAIS 382
|
|
| pheT |
PRK00629 |
phenylalanyl-tRNA synthetase subunit beta; Reviewed |
908-993 |
1.52e-07 |
|
phenylalanyl-tRNA synthetase subunit beta; Reviewed
Pssm-ID: 234804 [Multi-domain] Cd Length: 791 Bit Score: 55.56 E-value: 1.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 908 EEDEIIPSRLDLR---VGKIVGVEKHPAADTLYLEKIDIGEEqPRTVVSG-------LVAYVSQE--ELQDRLVvvlcnL 975
Cdd:PRK00629 31 EVEGVEDVAAGLSgvvVGKVLECEKHPNADKLRVCQVDVGEE-PLQIVCGapnvragDKVPVALPgaVLPGGFK-----I 104
|
90
....*....|....*...
gi 1832123188 976 KPQKMRGIESQAMlLCAS 993
Cdd:PRK00629 105 KKAKLRGVESEGM-LCSA 121
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
247-410 |
2.28e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 48.05 E-value: 2.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 247 VICAIYVLCAITLFCGVKERKenskvHSERMSFFRGIRLVMGHGPYAKLVMGFLFTSLAFMLLEGNFALFCSYTLGF-RD 325
Cdd:COG2814 169 VNAVLALLALLLLLRLLPESR-----PAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLsAS 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 326 DFQNVLLVVMLSATLTIPFWQWFLTRFGKKTAVYVGTTIVIPFLITVVLMkSNLIVTYVIAIASGVSIAAAFLLPWSMLP 405
Cdd:COG2814 244 AAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALA-GSLWLLLLALFLLGFGFGLLFPLLQALVA 322
|
....*
gi 1832123188 406 DVVDD 410
Cdd:COG2814 323 ELAPP 327
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
244-437 |
1.99e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 45.14 E-value: 1.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 244 ASGVICAI-YVLCAITLFCGVKERKENSKVHSERMSF--FRGIRLVMGHGPYAKLVMGFLFTSLAF-------MLLEGNF 313
Cdd:COG2270 185 ISFLLTALwWLLFALPLFLFLPERPRPGPAPPRGAVRagFRELRRTLRELRRYRDLLRFLLAYFFYrdgvqtvIAFAGIY 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 314 AlfcSYTLGFR-DDFQNVLLVVMLSATLTIPFWQWFLTRFGKKTAVYVGTTIVIPFLITVVLMKSNLIVtYVIAIASGVS 392
Cdd:COG2270 265 A---AGVLGFStTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAF-WILGLLIGLV 340
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1832123188 393 IAAAFLLPWSMLPDVVddfkvlnPEsqGHEAIFYSFYVFFTKFAS 437
Cdd:COG2270 341 MGGIQALSRSLLARLI-------PP--GREAEFFGLYALSGKAAS 376
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
237-408 |
5.03e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 43.72 E-value: 5.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 237 VRNAYMIASgvicAIYVLCAITLFCGVKERKENSKVHSErmSFFRGIRLVMGHGPYAKLVMGFLFTSLAFMLLEGNFALF 316
Cdd:COG2223 158 WRNAFLILG----ILLLVVAVLAWLFLRDPPAGAAAAAK--ASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPY 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 317 csYTLGFRDDFQNVLLVVM---LSATLTIPFWQWFLTRFGKKTAVYVGTTIVIPFLITVVLMKSNLIVTYVIAIASGVSI 393
Cdd:COG2223 232 --LVDQFGLSAATAGLLAAlfaLLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLAL 309
|
170
....*....|....*
gi 1832123188 394 AAAFLLPWSMLPDVV 408
Cdd:COG2223 310 GGGNGAVFALVPDIF 324
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
295-496 |
1.59e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.02 E-value: 1.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 295 LVMGFLFTSLAFMLLEGNFALFCSYTLGF-RDDFQNVLLVVMLSATLTIPFWQWFLTRFGKKTaVYVGTTIVIPFLITVV 373
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGIsPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRR-VLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 374 LMKSNLIVTYVIAIASGVSIAAAFLLPWSMLPDVVDDfkvlnpesqGHEAIFYSFYVFFTKFASGVSLGISTLSLDFAGY 453
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPP---------EERGRALGLVSAGFGLGAALGPLLGGLLASLFGW 150
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1832123188 454 VTrgctqpkavdvtlkVLVSAAPVALIFIGLLIFTSYPINEKR 496
Cdd:pfam07690 151 RA--------------AFLILAILSLLAAVLLLLPRPPPESKR 179
|
|
| PTZ00348 |
PTZ00348 |
tyrosyl-tRNA synthetase; Provisional |
798-905 |
1.95e-03 |
|
tyrosyl-tRNA synthetase; Provisional
Pssm-ID: 173541 [Multi-domain] Cd Length: 682 Bit Score: 42.20 E-value: 1.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 798 AFCEPgNIQNNGVLSFVKHVLFPlHSEFAIKRDPKFGGDKVYTFYEELEKDFAEERIHPGDLKASVevaLDKLLD--PIR 875
Cdd:PTZ00348 582 AYSAP-NEEANPVISVAQHLLAQ-QGALSIERGEANGGNVAYNTPEALVADCGSGALHPADLKAAV---SQLLLDrsAAA 656
|
90 100 110
....*....|....*....|....*....|
gi 1832123188 876 KKFETPELKKLTSLAypsknKNAVKVNPKK 905
Cdd:PTZ00348 657 RALLSGELKKNMQTL-----RNAEKKLSKR 681
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
57-260 |
2.24e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 41.77 E-value: 2.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 57 ALGFFLQIYLLDVALLDPFYASVILFVGRAWDAITDPTVGFLVSRTPwtrfgrmmPWIILSTPFAVMSYFLIWYVpPVDQ 136
Cdd:cd17321 186 GLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFG--------PRLVLVAGLLLTAVGLLLLA-LLGA 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 137 TKVVWYLIFYCLFQTLQTCFHVPYSALTMFISSEQKERDSATAYRMTVEVLGTVIGTGIQGQIVGMANAPCIPVGNDLNA 216
Cdd:cd17321 257 DSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSANLGDSGVAAL 336
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1832123188 217 TFRNSGSEAnitqpdlslDKVRNAyMIASGVICAIYVLCAITLF 260
Cdd:cd17321 337 LSAAAAAFA---------AGFHLA-FLVAAALALLAALLALLLP 370
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
298-397 |
3.26e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 41.36 E-value: 3.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 298 GFLFTSLAFMLLEGNFALFCSYTLGF--------RDDFQNVLLVVMLSATLTIPFWQWFLTRFGKKTAVYVGTTIVIPFL 369
Cdd:cd17369 229 ALLLAIGLRLAENVLFYLFTTFALSYatqtlgvdRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFA 308
|
90 100 110
....*....|....*....|....*....|.
gi 1832123188 370 ITVVLM---KSNLIVTYVIAIASGVSIAAAF 397
Cdd:cd17369 309 FPFFWLldtGSTWLIVLAAVVVLGVLHGMMY 339
|
|
| trpS |
TIGR00233 |
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members ... |
588-773 |
4.02e-03 |
|
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members of the family have a pfam00458 domain amino-terminal to the region described by this model. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 272975 [Multi-domain] Cd Length: 327 Bit Score: 40.78 E-value: 4.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 588 VYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAFLdnmkAPWELLELRVKYYEQVIKAMLeSIGVPLDKLKF 667
Cdd:TIGR00233 5 VLTGIQPSGKMHLGHYLGAIQTKWLQQFGVELFICIADLHAIT----VKQTDPDALRKAREELAADYL-AVGLDPEKTFI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 668 VKGTEYQlsrEYTLDVYRLSSMVTEHDAKKAGAEVVKQVEHPLLSGLL-YPGLQALDEEYLKVDAQFGGVDQRKIFTL-- 744
Cdd:TIGR00233 80 FLQSDYP---EHYELAWLLSCQVTFGELKRMTQFKDKSQAENVPIGLLsYPVLQAADILLYQADLVPVGIDQDQHLELtr 156
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1832123188 745 --AEK---------YLPSLGYTKrihmMNPMVPGLTGSKM 773
Cdd:TIGR00233 157 dlAERfnkkfknffPKPESLISK----FFPRLMGLSGKKM 192
|
|
| PRK12285 |
PRK12285 |
tryptophanyl-tRNA synthetase; Reviewed |
588-773 |
8.95e-03 |
|
tryptophanyl-tRNA synthetase; Reviewed
Pssm-ID: 237037 [Multi-domain] Cd Length: 368 Bit Score: 39.85 E-value: 8.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 588 VYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAFLDNMKAPWELLELRVKYyeqvikaMLESIGVPLDKLKf 667
Cdd:PRK12285 69 VYTGFMPSGPMHIGHKMVFDELKWHQEFGANVYIPIADDEAYAARGLSWEETREWAYEY-------ILDLIALGFDPDK- 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832123188 668 vkgTEYQLSREYTlDVYRLSSMVtehdAKKAGAEVVKQV----EHPLLSGLLYPGLQALDEEYLKVDAQFG------GVD 737
Cdd:PRK12285 141 ---TEIYFQSENI-KVYDLAFEL----AKKVNFSELKAIygftGETNIGHIFYPATQAADILHPQLEEGPKptlvpvGID 212
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1832123188 738 Q----RKIFTLAEKYLPSLGYTKRIHMMNPMVPGLTGSKM 773
Cdd:PRK12285 213 QdphiRLTRDIAERLHGGYGFIKPSSTYHKFMPGLTGGKM 252
|
|
| |
