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Conserved domains on  [gi|1826728760|gb|KAF3781949|]
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DELLA protein [Nymphaea thermarum]

Protein Classification

GRAS family protein( domain architecture ID 10572318)

GRAS family protein such as Arabidopsis thaliana protein SCARECROW, a transcription factor required for quiescent center cells specification and maintenance of surrounding stem cells, and for the asymmetric cell division involved in radial pattern formation in roots

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
GRAS pfam03514
GRAS domain family; Proteins in the GRAS (GAI, RGA, SCR) family are known as major players in ...
236-600 0e+00

GRAS domain family; Proteins in the GRAS (GAI, RGA, SCR) family are known as major players in gibberellin (GA) signaling, which regulates various aspects of plant growth and development. Mutation of the SCARECROW (SCR) gene results in a radial pattern defect, loss of a ground tissue layer, in the root. The PAT1 protein is involved in phytochrome A signal transduction. A sequence, structure and evolutionary analysis showed that the GRAS family emerged in bacteria and belongs to the Rossmann-fold, AdoMET (SAM)-dependent methyltransferase superfamily. All bacterial, and a subset of plant GRAS proteins, are predicted to be active and function as small-molecule methylases. Several plant GRAS proteins lack one or more AdoMet (SAM)-binding residues while preserving their substrate-binding residues. Although GRAS proteins are implicated to function as transcriptional factors, the above analysis suggests that they instead might either modify or bind small molecules.


:

Pssm-ID: 397536  Cd Length: 374  Bit Score: 520.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826728760 236 LVHTLMACAEAVQQDNLKLAEALVKQIGVLAASQAGAMRKVATFFAEALARRIYRLYPG---------DSPNDAFSDLLQ 306
Cdd:pfam03514   1 LVHLLLACAEAVSSGDLSLAQAILARLNQLASPAGDPMQRLAAYFTEALAARLARSGSSiysalpprpTSPSDSIERISA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826728760 307 MH-FYEACPYLKFAHFTANQAILEAFAGKPRVHVIDFSMKQGMQWPALMQALALRPGGPPAFRLTGVGPPQRDNSDPLQE 385
Cdd:pfam03514  81 YKlFYEVSPYLKFGHFTANQAILEAFEGEERVHIIDFDIGQGLQWPSLIQALASRPGGPPHLRITGIGDPQFSSAEELEE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826728760 386 VGWKLAQFAETINVEFEYRGLVATSLADIEAYMLDLRPtdGEVVAVNSIFELHQLLAQPGAM----DKVLSLVRSVQPQI 461
Cdd:pfam03514 161 TGDRLAQFADSLGVPFEFNPLVAKRLEDLDLEMLDVRP--GEALAVNCVFALHRLLDESVSLesprDTFLRLVRSLNPKV 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826728760 462 VTVVEQEAAHNGPVFLDRFTEALHYYSSLFDSLEgctGGSSPATGQDQVMSEVYLGRQICNIVACEGAERVERHETLGQW 541
Cdd:pfam03514 239 VTLVEQEANHNSAPFLNRFVEALHYYSALFDSLE---ATLPRDSEERRKVERELLGREIVNVVACEGAERVERHETFGKW 315
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1826728760 542 RARMGPAGFAPVHLGSNAFKQASMLLALFaGGDGYRVEENNGCLMLGWHTRPLIATSAW 600
Cdd:pfam03514 316 RERMRRAGFRPVPLSEFAVKQAKLLLRLY-YVDGYTVEEDNGSLVLGWKGRPLVAASAW 373
DELLA pfam12041
Transcriptional regulator DELLA protein N terminal; Gibberellins are plant hormones which have ...
43-110 4.55e-44

Transcriptional regulator DELLA protein N terminal; Gibberellins are plant hormones which have great impact on growth signalling. DELLA proteins are transcriptional regulators of growth related proteins which are downregulated when gibberellins bind to their receptor GID1. GID1 forms a complex with DELLA proteins and signals them towards 26S proteasome. The N terminal of DELLA proteins contains conserved DELLA and VHYNP motifs which are important for GID1 binding and proteolysis of the DELLA proteins.


:

Pssm-ID: 403308  Cd Length: 68  Bit Score: 151.39  E-value: 4.55e-44
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1826728760  43 DELLAALGYNVRSSDMAEVAQKLEQLEMVMGSAQEDGISHLSSETVHYNPSDIATWIETMLSELNPPP 110
Cdd:pfam12041   1 DELLAVLGYKVRSSDMADVAQKLEQLEMVMGNAQEDGISHLASDTVHYNPSDLSSWVESMLSELNPPP 68
 
Name Accession Description Interval E-value
GRAS pfam03514
GRAS domain family; Proteins in the GRAS (GAI, RGA, SCR) family are known as major players in ...
236-600 0e+00

GRAS domain family; Proteins in the GRAS (GAI, RGA, SCR) family are known as major players in gibberellin (GA) signaling, which regulates various aspects of plant growth and development. Mutation of the SCARECROW (SCR) gene results in a radial pattern defect, loss of a ground tissue layer, in the root. The PAT1 protein is involved in phytochrome A signal transduction. A sequence, structure and evolutionary analysis showed that the GRAS family emerged in bacteria and belongs to the Rossmann-fold, AdoMET (SAM)-dependent methyltransferase superfamily. All bacterial, and a subset of plant GRAS proteins, are predicted to be active and function as small-molecule methylases. Several plant GRAS proteins lack one or more AdoMet (SAM)-binding residues while preserving their substrate-binding residues. Although GRAS proteins are implicated to function as transcriptional factors, the above analysis suggests that they instead might either modify or bind small molecules.


Pssm-ID: 397536  Cd Length: 374  Bit Score: 520.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826728760 236 LVHTLMACAEAVQQDNLKLAEALVKQIGVLAASQAGAMRKVATFFAEALARRIYRLYPG---------DSPNDAFSDLLQ 306
Cdd:pfam03514   1 LVHLLLACAEAVSSGDLSLAQAILARLNQLASPAGDPMQRLAAYFTEALAARLARSGSSiysalpprpTSPSDSIERISA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826728760 307 MH-FYEACPYLKFAHFTANQAILEAFAGKPRVHVIDFSMKQGMQWPALMQALALRPGGPPAFRLTGVGPPQRDNSDPLQE 385
Cdd:pfam03514  81 YKlFYEVSPYLKFGHFTANQAILEAFEGEERVHIIDFDIGQGLQWPSLIQALASRPGGPPHLRITGIGDPQFSSAEELEE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826728760 386 VGWKLAQFAETINVEFEYRGLVATSLADIEAYMLDLRPtdGEVVAVNSIFELHQLLAQPGAM----DKVLSLVRSVQPQI 461
Cdd:pfam03514 161 TGDRLAQFADSLGVPFEFNPLVAKRLEDLDLEMLDVRP--GEALAVNCVFALHRLLDESVSLesprDTFLRLVRSLNPKV 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826728760 462 VTVVEQEAAHNGPVFLDRFTEALHYYSSLFDSLEgctGGSSPATGQDQVMSEVYLGRQICNIVACEGAERVERHETLGQW 541
Cdd:pfam03514 239 VTLVEQEANHNSAPFLNRFVEALHYYSALFDSLE---ATLPRDSEERRKVERELLGREIVNVVACEGAERVERHETFGKW 315
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1826728760 542 RARMGPAGFAPVHLGSNAFKQASMLLALFaGGDGYRVEENNGCLMLGWHTRPLIATSAW 600
Cdd:pfam03514 316 RERMRRAGFRPVPLSEFAVKQAKLLLRLY-YVDGYTVEEDNGSLVLGWKGRPLVAASAW 373
DELLA pfam12041
Transcriptional regulator DELLA protein N terminal; Gibberellins are plant hormones which have ...
43-110 4.55e-44

Transcriptional regulator DELLA protein N terminal; Gibberellins are plant hormones which have great impact on growth signalling. DELLA proteins are transcriptional regulators of growth related proteins which are downregulated when gibberellins bind to their receptor GID1. GID1 forms a complex with DELLA proteins and signals them towards 26S proteasome. The N terminal of DELLA proteins contains conserved DELLA and VHYNP motifs which are important for GID1 binding and proteolysis of the DELLA proteins.


Pssm-ID: 403308  Cd Length: 68  Bit Score: 151.39  E-value: 4.55e-44
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1826728760  43 DELLAALGYNVRSSDMAEVAQKLEQLEMVMGSAQEDGISHLSSETVHYNPSDIATWIETMLSELNPPP 110
Cdd:pfam12041   1 DELLAVLGYKVRSSDMADVAQKLEQLEMVMGNAQEDGISHLASDTVHYNPSDLSSWVESMLSELNPPP 68
 
Name Accession Description Interval E-value
GRAS pfam03514
GRAS domain family; Proteins in the GRAS (GAI, RGA, SCR) family are known as major players in ...
236-600 0e+00

GRAS domain family; Proteins in the GRAS (GAI, RGA, SCR) family are known as major players in gibberellin (GA) signaling, which regulates various aspects of plant growth and development. Mutation of the SCARECROW (SCR) gene results in a radial pattern defect, loss of a ground tissue layer, in the root. The PAT1 protein is involved in phytochrome A signal transduction. A sequence, structure and evolutionary analysis showed that the GRAS family emerged in bacteria and belongs to the Rossmann-fold, AdoMET (SAM)-dependent methyltransferase superfamily. All bacterial, and a subset of plant GRAS proteins, are predicted to be active and function as small-molecule methylases. Several plant GRAS proteins lack one or more AdoMet (SAM)-binding residues while preserving their substrate-binding residues. Although GRAS proteins are implicated to function as transcriptional factors, the above analysis suggests that they instead might either modify or bind small molecules.


Pssm-ID: 397536  Cd Length: 374  Bit Score: 520.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826728760 236 LVHTLMACAEAVQQDNLKLAEALVKQIGVLAASQAGAMRKVATFFAEALARRIYRLYPG---------DSPNDAFSDLLQ 306
Cdd:pfam03514   1 LVHLLLACAEAVSSGDLSLAQAILARLNQLASPAGDPMQRLAAYFTEALAARLARSGSSiysalpprpTSPSDSIERISA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826728760 307 MH-FYEACPYLKFAHFTANQAILEAFAGKPRVHVIDFSMKQGMQWPALMQALALRPGGPPAFRLTGVGPPQRDNSDPLQE 385
Cdd:pfam03514  81 YKlFYEVSPYLKFGHFTANQAILEAFEGEERVHIIDFDIGQGLQWPSLIQALASRPGGPPHLRITGIGDPQFSSAEELEE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826728760 386 VGWKLAQFAETINVEFEYRGLVATSLADIEAYMLDLRPtdGEVVAVNSIFELHQLLAQPGAM----DKVLSLVRSVQPQI 461
Cdd:pfam03514 161 TGDRLAQFADSLGVPFEFNPLVAKRLEDLDLEMLDVRP--GEALAVNCVFALHRLLDESVSLesprDTFLRLVRSLNPKV 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1826728760 462 VTVVEQEAAHNGPVFLDRFTEALHYYSSLFDSLEgctGGSSPATGQDQVMSEVYLGRQICNIVACEGAERVERHETLGQW 541
Cdd:pfam03514 239 VTLVEQEANHNSAPFLNRFVEALHYYSALFDSLE---ATLPRDSEERRKVERELLGREIVNVVACEGAERVERHETFGKW 315
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1826728760 542 RARMGPAGFAPVHLGSNAFKQASMLLALFaGGDGYRVEENNGCLMLGWHTRPLIATSAW 600
Cdd:pfam03514 316 RERMRRAGFRPVPLSEFAVKQAKLLLRLY-YVDGYTVEEDNGSLVLGWKGRPLVAASAW 373
DELLA pfam12041
Transcriptional regulator DELLA protein N terminal; Gibberellins are plant hormones which have ...
43-110 4.55e-44

Transcriptional regulator DELLA protein N terminal; Gibberellins are plant hormones which have great impact on growth signalling. DELLA proteins are transcriptional regulators of growth related proteins which are downregulated when gibberellins bind to their receptor GID1. GID1 forms a complex with DELLA proteins and signals them towards 26S proteasome. The N terminal of DELLA proteins contains conserved DELLA and VHYNP motifs which are important for GID1 binding and proteolysis of the DELLA proteins.


Pssm-ID: 403308  Cd Length: 68  Bit Score: 151.39  E-value: 4.55e-44
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1826728760  43 DELLAALGYNVRSSDMAEVAQKLEQLEMVMGSAQEDGISHLSSETVHYNPSDIATWIETMLSELNPPP 110
Cdd:pfam12041   1 DELLAVLGYKVRSSDMADVAQKLEQLEMVMGNAQEDGISHLASDTVHYNPSDLSSWVESMLSELNPPP 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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