|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
24-435 |
2.30e-49 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 171.63 E-value: 2.30e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 24 FGIISFSLLLTGFLSYSGNVVLAKLVS--NGWSNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAA 101
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 102 TGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFS----WRI 177
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 178 MFLLGGIGILLAWLLsgkyfiesprwlagkgqiagaecqlreveqqiereksirlppltsyqsnskvkvikgtfwllfkg 257
Cdd:cd17316 161 LFLIGALPALLALLL----------------------------------------------------------------- 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 258 emLRRTLVAITVLIAMNISLYTITVWIPTIFVN-SGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRRLFGSTLLIII 336
Cdd:cd17316 176 --RRRTLLLILLWFFISFGYYGLTTFLPTYLQTvLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILS 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 337 AVLGYIYSIQ-TTEWAILIYGLVMIFFLYMYVCFASAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGS 415
Cdd:cd17316 254 GILALPLFYLlSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGG 333
|
410 420
....*....|....*....|
gi 1785684408 416 ITVFMVLGVMLLLCALVLSI 435
Cdd:cd17316 334 TGVPALILALLAIVALIVAL 353
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
54-447 |
2.12e-35 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 137.07 E-value: 2.12e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 54 SNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYA 133
Cdd:TIGR00898 124 EDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVV 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 134 SFTEFIPATVRGkWSARLSFVGnWSpmlsaaIGVVVIAFF-----SWRIMFLL----GGIGILLAWllsgkYFIESPRWL 204
Cdd:TIGR00898 204 LNTEFLPKKQRA-IVGTLIQVF-FS------LGLVLLPLVayfipDWRWLQLAvslpTFLFFLLSW-----FVPESPRWL 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 205 AGKGQIAGAECQLREVEQQIEREKSIRLPPLTSYQSNSKVKVIKGTFWLLFKGEMLRRTLVAITVLIAMNISLYTITVWI 284
Cdd:TIGR00898 271 ISQGRIEEALKILQRIAKINGKKLPAEVLSLSLEKDLSSSKKQYSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDL 350
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 285 PTIFVNSGIDVdksILMTAVIMIGApvgiFIAALIIDHFPRR--------LFGSTLLIIIAVLGYIYSIQTtewAILIYG 356
Cdd:TIGR00898 351 GNLGGNIYLDL---FISGLVELPAK----LITLLLIDRLGRRytmaasllLAGVALLLLLFVPVDLYFLRT---ALAVLG 420
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 357 LVMIFFLYMYVCfasaVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAAllthyGSITVFMVLGVM--LLLCALVLS 434
Cdd:TIGR00898 421 KFGITSAFQMVY----LYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVYL-----GEKWLFLPLVLFggLALLAGILT 491
|
410
....*....|...
gi 1785684408 435 IFGIETRKVSLEE 447
Cdd:TIGR00898 492 LFLPETKGVPLPE 504
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
64-410 |
7.80e-33 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 128.24 E-value: 7.80e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 64 SALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATV 143
Cdd:TIGR00895 59 SAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRF 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 144 RGKwSARLSFVG-NWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWLLSGKYFIESPRWLAGKGQIAGAEcQLREVEQ 222
Cdd:TIGR00895 139 RGT-AVGLMFCGyPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDFLVSKRPETVRR-IVNAIAP 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 223 QIEREKSIRLPPltsyqSNSKVKVIKGTFWLLFKGEMLRRTLVAITVLIAMNISLYTITVWIPTIFVNSGIDVDKSILMT 302
Cdd:TIGR00895 217 QMQAEAQSALPE-----QKSTQGTKRSVFKALFQGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGG 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 303 AVIMIGAPVGIFIAALIIDHFPRRLFGStLLIIIAVLGYIYSIQTTEWAILIYGLVMIFFLYMYVCFASAVYIPELWPTH 382
Cdd:TIGR00895 292 ALFNFGGVIGSIIFGWLADRLGPRVTAL-LLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTA 370
|
330 340
....*....|....*....|....*...
gi 1785684408 383 LRLRGSGFVNAVGRIVAVFTPYGVAALL 410
Cdd:TIGR00895 371 IRATGVGWAIGIGRLGAIIGPILAGYLL 398
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
18-442 |
1.54e-29 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 118.43 E-value: 1.54e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 18 RFHYRIFGIISFSLLLTGFLSYSGNVVLAKLVSN-GWSNNFLnAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLI 96
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADlGLSAAQL-GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 97 VGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWR 176
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 177 IMFLLGGIGILLAWLLsgkyfiesprwlagkgqiagaecqlreveqqiereksirlppltsyqsnskvkvikgtfwllfk 256
Cdd:COG2271 165 AAFLILGLPGLLLALL---------------------------------------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 257 gemlrRTLVAITVLIAMNISLYTITVWIPTIFVNS-GIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRR--LFGSTLL 333
Cdd:COG2271 181 -----RFWLLALAYFLVYFALYGFLTWLPTYLVEVrGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGL 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 334 IIIAVLGYIYSIQTTEWAILIYGLVMIFFLYMYVCFASAvYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHY 413
Cdd:COG2271 256 LLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWA-LAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT 334
|
410 420
....*....|....*....|....*....
gi 1785684408 414 GSITVFMVLGVMLLLCALVLSIFGIETRK 442
Cdd:COG2271 335 GYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
24-451 |
1.22e-28 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 117.37 E-value: 1.22e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 24 FGIISFSLLLTGFLSYSGnvvLAKLVSNGWSNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRIN--LLIVGIAA 101
Cdd:pfam00083 16 TGVIGAFLTLIDFFKNFG---LSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIAnvLFVIGAVL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 102 TGAAFVPDMYWLIFF-RFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFS---WRI 177
Cdd:pfam00083 93 QGAAKGKWSVYQLIVgRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSNsdgWRI 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 178 MFLLGGIGILLawLLSGKYFI-ESPRWLAGKGQIAGAecqlREVEQQIEREKSIRLPPLTSYQSNSKVKVIKGTFWLLFK 256
Cdd:pfam00083 173 PLGLQLVPALL--LIIGLLFLpESPRWLVEKGRLEEA----REVLAKLRGVPDVDRELDEIKDSLEAGQEAEKASWKELF 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 257 GEMLRRTLVAITVLIAMNISLYTITVWI---PTIFVNSGidVDKSILMTAVIMIGAPVGIFIAALIIDHFPRRLFGSTLL 333
Cdd:pfam00083 247 STKTRRQRLLIGVMLQIFQQLTGINAIFyysTTIFENLG--LSDSFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLLLLGA 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 334 IIIAVLGYIYSIQTTEW--AILIYGLVMIFFLYMYVCFASA-------VYIPELWPTHLRLRGSGFVNAVGRIVAVFTPY 404
Cdd:pfam00083 325 AGMAICFVILGIVALLGvsKSDWAGIVAIVFIALFIAFFAMgwgpvpwVIVSELFPLSVRSKAMALATAANWLANFLIGF 404
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 1785684408 405 GVAALLTHYGSITVFMVLGVMLLLCALVLSIFGIETRKVSLEEISEV 451
Cdd:pfam00083 405 LFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTLEEIDEL 451
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
63-440 |
1.26e-25 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 107.77 E-value: 1.26e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 63 TSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPAT 142
Cdd:cd17371 40 GTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPAR 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 143 VRGKwsaRLSFV-GNWSPMLSAAIGVVVIAF------FSWRIMFLLGGIGILLAWLLSgKYFIESPRWLAGKGqiAGAEC 215
Cdd:cd17371 120 HRGK---ALGYVqSGWAVGWLLATLLAALLFpllppeIAWRVLFLLGALPALLVLFIR-RFVKEPPQWQAARA--ARRHF 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 216 QLREveqqiereksirlppltsyqsnskvkvikgTFWLLFKGEMLRRTLVAITVLIAMNISLYTITVWIPTIFVNS-GID 294
Cdd:cd17371 194 ADRP------------------------------SLRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTGErGLS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 295 VDKSILMTAVIMIGAPVGIFIAALIIDHFPRR---LFGStLLIIIAVLGYIYSIQTTEwAILIYGLVMIFFLYMYVCFAS 371
Cdd:cd17371 244 FEGSAGYLVVTILGGFLGYLAGGFLADRIGRRnnfALFA-LGSAISILLYFFLPLSPT-LILILGFPLGFFASGPFSGMG 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1785684408 372 AvYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVMLLLCALVLSIFGIET 440
Cdd:cd17371 322 A-YLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLLPET 389
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
25-448 |
1.66e-25 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 108.58 E-value: 1.66e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 25 GIISFSLLLTGFLSYSGNVVLAKLVSNGWSNnflnaaFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATG- 103
Cdd:TIGR00879 45 GVIGGALALPAFEFKFTSANSDSYSSSLWGL------VVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIGAILm 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 104 --AAFVPDMYWLIFFRFLMGTGMG--ALIMVGYASftEFIPATVRGKwsarlsfvGNWSPMLSAAIGVVVIAFFS----- 174
Cdd:TIGR00879 119 glAAFALSVEMLIVGRVLLGIGVGiaSALVPMYLS--EIAPKALRGA--------LTSLYQLAITFGILVAYGFGsgkvs 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 175 ------WRIMFLLGGI--GILLAWLLSgkyFIESPRWLAGKGQIAGAECQLREVEQQIEREKSI----RLPPLTSYQSNS 242
Cdd:TIGR00879 189 lnntlgWRIPLGLQLIpaGLLFLGLFF---LPESPRWLVGKGRVEEARKSLARLRGTSGEDKELldelELIDIKRSIEKR 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 243 KVKVIKGTFWLLFKGEMLRRTLVAITVLIAMNISLYTITVWIPTIFVNSGIDVDKSILMTAVIMIGAPVGIFIAALIIDH 322
Cdd:TIGR00879 266 SVQPSWGSLFSSTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVSTDHAFLVSIIVGAVNFAFTFVAIFLVDR 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 323 FPRR-------LFGSTLLIIIAVLGYIYSIQTTEWAiliyGLVMIFFLYMYVCFASA-------VYIPELWPthLRLRGS 388
Cdd:TIGR00879 346 FGRRpllligaAGMAICLFVLGILGASFVTGSSKSS----GNVAIVFILLFIAFFAMgwgpvpwVIVSEIFP--LSLRPK 419
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1785684408 389 GFVNAVGR------IVAVFTPYGVAALlthyGSITVFMVLGVMLLLCALVLSIFGIETRKVSLEEI 448
Cdd:TIGR00879 420 GISIAVAAnwlanfIVGFLFPTMLESI----GVGGVFIFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
17-397 |
1.91e-24 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 103.52 E-value: 1.91e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 17 ARFHYRIFGIISFSLLLTGFLSYSGNVVLAKLVSNGWSNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLI 96
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 97 VGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWR 176
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 177 IMFLLGGIGILLAWLLSGKYFIESPRWLAGKgqiagaecqlreveqqiereksirlppltsyqsnskvkvIKGTFWLLFK 256
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLLPESRPAARAR---------------------------------------LRGSLRELLR 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 257 gemLRRTLVAITVLIAMNISLYTITVWIPTIFVN-SGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRRLFGSTLLII 335
Cdd:COG2814 206 ---RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLL 282
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1785684408 336 IAVLGYIYSIQTTEWAILIYGLVMIFFLYMYVCFASAvYIPELWPTHLRLRGSGFVNAVGRI 397
Cdd:COG2814 283 LALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQA-LVAELAPPEARGRASGLYNSAFFL 343
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
20-444 |
9.23e-23 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 99.57 E-value: 9.23e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 20 HYRIFGIISFSLLLTGFLSYSGNVVLAKLVSN-GWSNNFLnAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVG 98
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEfGLSAAQL-GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 99 IAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIM 178
Cdd:COG2223 82 IGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 179 FLLGGIGILLAWLLSGKYFIESPRWLAGKGQIAGAEcqlreveqqiereksiRLPPLTSYQsnskvkvikgtFWLLFkge 258
Cdd:COG2223 162 FLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRD----------------QLEALRDPR-----------FWLLS--- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 259 mlrrtlvaiTVLIAMNISLYTITVWIPTIFVNS-GIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRRLFGSTLLIIIA 337
Cdd:COG2223 212 ---------LLYFGTFGSFIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMA 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 338 VLGYIYSIQTTEWAILIYGLVMIFFLYMYVCFASAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSIT 417
Cdd:COG2223 283 LGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYT 362
|
410 420
....*....|....*....|....*...
gi 1785684408 418 -VFMVLGVMLLLCALVLSIFGIETRKVS 444
Cdd:COG2223 363 aAFLVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
63-431 |
1.52e-21 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 95.71 E-value: 1.52e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 63 TSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPAT 142
Cdd:cd17359 42 VSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 143 VRGKWSAR----------LSFVGNWSPMLSAAIGVVVIAffSWRIMFLLGGIGILLAWLLSgkYFI-ESPRWLAGKGQIA 211
Cdd:cd17359 122 IRGRLVSLnqlmivfgqlLAYIVNYLIANAGGADWLGAE--GWRWMLGLEAIPAILFLLGM--LFIpESPRWLVSKGKPI 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 212 gaecqlreveqqiereksirlppltsyqsnskvkVIKGTFWLLFKGemlrrtlvaitvLIAMNISLYtitvWIPTIFVNS 291
Cdd:cd17359 198 ----------------------------------LIIGIGLAIFQQ------------FVGINVIFY----YGPEIFQNA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 292 GIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRR---LFGS-----TLLIIIAVLGYIYSIQTTEWAILIYGLVMIFFL 363
Cdd:cd17359 228 GFSENAALLQTIGIGVVNVIFTIIAILLVDKVGRKpllLIGSigmaiSLLLIGTAFYFAPGSQASGIVALVLILLFVAFF 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1785684408 364 YMYVCFASAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVMLLLCAL 431
Cdd:cd17359 308 AMSWGPVTWVLLSEIFPNRIRGLAMGIAVFFLWIANFLVSLTFPILLAAFGLAFTFLIFAVICVLAFL 375
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
62-447 |
7.28e-21 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 94.56 E-value: 7.28e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 62 FTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPA 141
Cdd:cd17358 46 FGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPK 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 142 TVRGkwsaRLSFVgnwsPMLSAAIGVVVI----AFFSWRIMFLLGgiGILLAWLLSGKYFI-ESPRWLAGKGQIAGAECQ 216
Cdd:cd17358 126 NVRG----ALGSL----NQLLVNIGILLGyvlgSFLPWRTLALIG--AIPPVVFLILLFFIpESPRWLAKKGREEEAEKS 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 217 L---REVEQQIEREksirLPPLTSYQSNSKVKVIKGTFWLLFKGEMLRRTLVAITVLIAMNIS-LYTITVWIPTIFVNSG 292
Cdd:cd17358 196 LqflRGKDADISKE----AAEIQEELAELEKEAKESSFSDLFQRKYLKPLVIGLGLMLFQQLSgINAVIFYASSIFDEAG 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 293 IDVDKSI--LMTAVIMIgapVGIFIAALIIDHFPRR--LFGSTLLIIIA--VLGYIYSIQTTEWAILIYGLVMIFFLYMY 366
Cdd:cd17358 272 SGLDPNTatIIIGVVQV---VGTLVATLLVDRLGRRplLLVSAIGMGIGllALGLYFYLQEHGALLSSVSWLPLVGLVIY 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 367 VCFASAVYIP-------ELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVMLLLCALVLSIFGIE 439
Cdd:cd17358 349 IISFSIGLGPlpwvimsEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFPFLTLAWGASGTFWIFAGICGLALVFVLLFVPE 428
|
....*...
gi 1785684408 440 TRKVSLEE 447
Cdd:cd17358 429 TKGKSLEE 436
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
64-435 |
8.32e-21 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 93.03 E-value: 8.32e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 64 SALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATV 143
Cdd:cd17365 41 SAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARR 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 144 RGKWSArLSFVG-NWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLawllsgkyfiesprwlagkgqiagaecqlreveq 222
Cdd:cd17365 121 RSLAVT-LMFCGyPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLI---------------------------------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 223 qiereksirLPPLtsyqsnskvkvikgtfwllfkgemLRRTLVAITVLIAMNISLYTITVWIPTIFVNSGIDVDKSILMT 302
Cdd:cd17365 166 ---------LLPL------------------------LRGTLLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTIT 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 303 AVIMIGAPVGIFIAALIIDHFPRRLFGSTLLIIIAVLGYIYSIQTTEWAILiygLVMIFFLYMYVCFASAV---YIPELW 379
Cdd:cd17365 213 LLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLL---YVLVFLAGACVNGAQVGlyaLAARFY 289
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1785684408 380 PTHLRLRGSGFVNAVGRIVAVFTPYGVAALLT-HYGSITVFMVLGVMLLLCALVLSI 435
Cdd:cd17365 290 PTEVRATGVGWALGVGRLGAILGPLLGGLLLAaGLGPESVFLALAIPAALGALAVLL 346
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
27-403 |
2.98e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 85.55 E-value: 2.98e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 27 ISFSLLLTGFLSYSGNVVLAKLVSN--GWSNNFLNAAFTsALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGA 104
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEdlGISPTEIGLLLT-LFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 105 AFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGI 184
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 185 GILLAWLLsgKYFIESPRWLAGKGQIAGAECQLREVEQQIEReksirlppltsyqsnskvkvikgtfwllfkgemlRRTL 264
Cdd:pfam07690 160 LSLLAAVL--LLLPRPPPESKRPKPAEEARLSLIVAWKALLR----------------------------------DPVL 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 265 VAITVLIAMNISLYTITVWIPTIFVNSGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRR--LFGSTLLIIIAVLGYI 342
Cdd:pfam07690 204 WLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRrrLLLALLLLILAALGLL 283
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1785684408 343 YSIQTTEWAILIYGLVMIFFLYMYVCFASAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTP 403
Cdd:pfam07690 284 LLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
72-433 |
1.11e-16 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 81.42 E-value: 1.11e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 72 IGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDM----YW----LIFFRFLMGTGM-----GALIMVgyasfTEF 138
Cdd:cd17369 59 LGGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYaqigILapilLVLLRLLQGLALggewgGAVLMA-----VEH 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 139 IPATVRGKWSarlSFVGNWSP---MLSAAIGVVVIAFFS--------WRIMFLLGGIGILLAwllsgkYFI-----ESPr 202
Cdd:cd17369 134 APPKRRGFYG---SFPQLGAPvglLLATGVFLLLSALLSdeaflswgWRIPFLLSAVLVAVG------LYIrlrleETP- 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 203 wlagkgqiagaecqlrEVEQQIEREKSIRLPPLTSYQSNSKVkvikgtfwllfkgemlrrTLVAITVLIAMNISLYTITV 282
Cdd:cd17369 204 ----------------VFRRAKEAGQVVRAPLVEVLRRHWRA------------------LLLAIGLRLAENVLFYLFTT 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 283 WIpTIFVNSGIDVDKSIlMTAVIMIGAPVG---IFIAALIIDHFPRR--LFGSTLLIIIAVLGYIYSIQTTEWAILIYGL 357
Cdd:cd17369 250 FA-LSYATQTLGVDRST-VLLAVLIASVVAaitIPLFGWLSDRVGRRpvYLAGALLAALFAFPFFWLLDTGSTWLIVLAA 327
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1785684408 358 VMIFFLYMYVCFAS-AVYIPELWPTHLRLRGSGFVNAVGRIVAV-FTPYGVAALLTHYGSIT-VFMVLGVMLLLCALVL 433
Cdd:cd17369 328 VVVLGVLHGMMYGPqAAFLAELFPTRVRYTGASLGYQLGAILGGgFAPLIATALVAATGSWWpVALYLAALAVISLVAA 406
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
17-192 |
1.35e-16 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 79.86 E-value: 1.35e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 17 ARFHYRIFGIISFSLLLTGFLSYSGNVVLAKLVSNGWSNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLI 96
Cdd:COG0477 9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 97 VGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWR 176
Cdd:COG0477 89 FGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR 168
|
170
....*....|....*.
gi 1785684408 177 IMFLLGGIGILLAWLL 192
Cdd:COG0477 169 WIFLINAPLGLLALVL 184
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
61-441 |
9.31e-16 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 78.84 E-value: 9.31e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 61 AFTSALMFGYFIGSLTGGFIGDYFGRRRAFRIN--LLIVGIAATGAAFVPDMY-WLIFFRFLMGTGMGALIMVGYASFTE 137
Cdd:cd17357 53 LIVSIFFIGGAIGSFISAFLANRFGRKNGLLISnaLLVVSSLLMFLSKSAKSPeLLIFGRFLVGIACGLSTGFVPMYLQE 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 138 FIPATVRGKWSARLSFVGNWSPMLSAAIGV--VVIAFFSWRIMFLLGGIGILLAWLLSGKYFiESPRWLAG-KGQIAGAE 214
Cdd:cd17357 133 ISPSELRGALGSLTQIGVTLGILLGQVFGLpsVLGTETLWPYLLFFPGIPALLQLAALPFFP-ESPKFLLIsKGDEEEAE 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 215 CQLR-----EVEQQIEREKSIRlppltsyQSNSKVKVIKGTFWLLFKGEMLR-RTLVAITVLIAMNISLYTITVWIPT-I 287
Cdd:cd17357 212 KSLKflrgiEDDVDQELEEIKK-------ESEQMGDQKQVSLMQLLRDPSLRlPLLLVLVVSASQQFSGINAIFFYSTfI 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 288 FVNSGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRR---LFGSTLLIIIAVLGYIYSIQTTEWAILIYGLVMIFFLY 364
Cdd:cd17357 285 FENAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRpllLISLSVCAVALLLMSVFLFLSEQNSWMSYGCIVAIFLF 364
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 365 MYvCFASAV------YIPELWPTHLR---LRGSGFVNAVGR-IVAVFTPYgvaalLTHYGSITVFMVLGVMLLLCALVLS 434
Cdd:cd17357 365 IF-FFAIGLgpipwfIGAELFPQAPRsaaQSLGSSVNWTSNfIVGMAFPP-----LQSIGGGFVFIIFAIPCALFLLYLY 438
|
....*..
gi 1785684408 435 IFGIETR 441
Cdd:cd17357 439 RYLPETK 445
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
54-436 |
1.91e-15 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 77.24 E-value: 1.91e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 54 SNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYA 133
Cdd:cd17317 22 DRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 134 SFTEFIPATVRgkwsarlsfvgnwspmlsaaIGVVVIAFFSWRI-MFLLGGIGillawllsgkYFIESPRWLagkgQIAg 212
Cdd:cd17317 102 LGMEIVGPKYR--------------------SFVGILFGLFWALgYMLLALLA----------YLIRDWRWL----QLA- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 213 aecqlreveqqiereksIRLPPLtsyqsnskvkvikGTFWLLFKgeMLRRTLVAITVLIAMNISLYTITVWIPT----IF 288
Cdd:cd17317 147 -----------------ISLPGL-------------LFLLLLWW--LPRRTIIVGLIWFVTSLVYYGLSLNSSNlggnLY 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 289 VNsgidvdkSILMTAVIMIgapvGIFIAALIIDHFPRR--LFGSTLLIIIAVLGYIYSIQTTEWAILIygLVMIFFLYMY 366
Cdd:cd17317 195 LN-------FFLSGLVEIP----AYFLALLLLDRLGRRwtLSGSLLLAGLACLVTALLPDDENTLALT--LALVGKFAIS 261
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1785684408 367 VCFA-SAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYgvAALLTHYGSITVFMVLGVMLLLCALVLSIF 436
Cdd:cd17317 262 AAFSvIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPF--IVLLGKIGPLLPLIIFGVLALLGGLLTLLL 330
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
63-436 |
5.03e-15 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 76.07 E-value: 5.03e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 63 TSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPAT 142
Cdd:cd17319 44 ASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPAR 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 143 VRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMF-LLGGIGILLAWLlsgkyfiesprwlagkgqiagaecqlreve 221
Cdd:cd17319 124 ERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFiIEGLLGLLLAVL------------------------------ 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 222 qqiereksirlppltsyqsnskvkvikgtfWLLFkgemLRRTLVAITVLIAMNISLYTITVWIPTIFVNS-GIDVDKSIL 300
Cdd:cd17319 174 ------------------------------WWFY----LRQVWGLALGYFGINYALYGLLTWLPTYLKQArGFSLKQVGL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 301 MTAVIMIGAPVGIFIAALIIDHFP----RRLFGSTLLIIIAVLGYIYSIQTTEWAILiyGLVMIFFLYMYVCFASAVYIP 376
Cdd:cd17319 220 LAAIPFLAGAIGMILGGRLSDRLLrgarRLVIIIGLLLAAVGLLLAYLTTSPVVAVI--LLSLAGFGIGAASPVFWSLPA 297
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 377 ELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVMLLLCALVLSIF 436
Cdd:cd17319 298 DLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
63-437 |
2.05e-13 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 71.44 E-value: 2.05e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 63 TSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVgyasftefIPAT 142
Cdd:COG2807 59 TTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVL--------LPGL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 143 VRGKWSARLSFV-------GNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWLLsgkyfiesprWLagkgqiagaec 215
Cdd:COG2807 131 IKRWFPDRVGLMtglytaaMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLL----------WL----------- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 216 qlreveqqiereksIRLPPLTSYQSNSKVKVIKGTFWllfkgemlrRTLVAITVLIAM---NISLYTITVWIPTIFVNSG 292
Cdd:COG2807 190 --------------PLLRRRPAAAAAAPAAASLRSLW---------RSPLAWLLTLFFglqSLLYYAVVAWLPPILRDAG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 293 IDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRR---LFGSTLLIIIAVLGYIYSIQTTE--WAILI-YGLVMIFFLYMy 366
Cdd:COG2807 247 LSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRrplLLLLGLLGLAGLLGLLLAPGSLPwlWAVLLgLGQGGLFPLAL- 325
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1785684408 367 vcfasaVYIPELWPTHLRL-RGSGFVNAVGRIVAVFTPYGVAALLTHYGSITV-FMVLGVMLLLCALVLSIFG 437
Cdd:COG2807 326 ------TLIGLRARTPAEAaALSGMAQSVGYLLAALGPLLVGALHDATGSWTAaLLLLAALAVLMLVAGLLAG 392
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
27-435 |
1.51e-12 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 68.61 E-value: 1.51e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 27 ISFSLLLTGFLSYSGNVVLAKLVSNGWSNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAF 106
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 107 VPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAF--FSWRIMFLLGGI 184
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 185 GILLaWLLSGKYFIESPRWLAgkgqiagaecqlreveqqieREKSIRLPPLTSYQSNSKVKVIKGTFWLLFkgemlrrtl 264
Cdd:cd06174 161 LALL-AAILLLLVVPDPPESA--------------------RAKNEEASSKSVLKLLKRVLKNPGLWLLLL--------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 265 vaitVLIAMNISLYTITVWIPTIFVNSGIDVDKSI-LMTAVIMIGAPVGIFIAALIIDHFPRRLFGSTLLIIIAVLGYIY 343
Cdd:cd06174 211 ----AIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAgLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLAL 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 344 SIQTTEWAILIYGLVMIFFLYMYVCFASAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLG 423
Cdd:cd06174 287 LLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVL 366
|
410
....*....|..
gi 1785684408 424 VMLLLCALVLSI 435
Cdd:cd06174 367 AVLLLLAAILLL 378
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
64-201 |
1.96e-12 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 68.37 E-value: 1.96e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 64 SALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATV 143
Cdd:cd17320 41 SAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAE 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1785684408 144 RGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWLLSGKYFIESP 201
Cdd:cd17320 121 LAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETL 178
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
63-451 |
1.03e-11 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 66.12 E-value: 1.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 63 TSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAAT-GAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPA 141
Cdd:cd17356 51 VSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIiQVAAIGKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPK 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 142 TVRGK------WSARL-SFVGNWSPMLSAAIGvvviAFFSWRIMFLLGGIGILLawLLSGKYFI-ESPRWLagkgqiaga 213
Cdd:cd17356 131 HIRGTlvslyqLAITIgILVAYCINYGTHKLD----GSAQWRIPLGLQIVWGLL--LLIGMFFLpESPRWL--------- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 214 ecqlreveqqiereksirlppltsyqsnskvkvikgtfwllfkgemlRRTLVAITV-----LIAMNISLYtitvWIPTIF 288
Cdd:cd17356 196 -----------------------------------------------YRTILGIMLqlfqqLTGINYFFY----YGTTIF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 289 VNSGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRR---LFGST----LLIIIAVLGYIYSIQTTEWAILIY--GLVM 359
Cdd:cd17356 225 QSTGLTGSSPLLTSIILYIVNFVSTIPGLFFVDKFGRRtclLIGAAgmsiCLFIYAAVGVRYLIPNPQSGTSNKsaGNGM 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 360 IFFLYMYVCFASA-------VYIPELWPTHLRLRGSGFVNAV----GRIVAVFTPYGVAALlthygSITVFMVLGVMLLL 428
Cdd:cd17356 305 IVFICLFIFSFATtwgpiawVYVAEVFPLRVRSKGMALATAFnwlwNFLISFFTPFIIGSI-----GFKYYYIFAGCNLL 379
|
410 420
....*....|....*....|...
gi 1785684408 429 CALVLSIFGIETRKVSLEEISEV 451
Cdd:cd17356 380 AFIVVFFFVPETKGLTLEEIDEL 402
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
27-436 |
2.52e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 64.90 E-value: 2.52e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 27 ISFSLLLTGFLSYSGNVVLAKLVSNGWSNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAF 106
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 107 VPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGI 186
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 187 LLAWLLsgkyfiesprwlagkgqiagaecqlreveqqierekSIRLPPLTSYQSNSKVKVIKGTFWLLFKGEMLRRTLVA 266
Cdd:cd17325 161 LLALVL------------------------------------ALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLAL 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 267 ITVLIAMNISLYTITVWIPTIFVNSGIDVDKSI-LMTAVIMIGAPVGIFIAALIIDHFPRRLFGSTLLIIIAVLGYIYSI 345
Cdd:cd17325 205 FLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIgLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 346 QTTEWAILIYGLVMIFFLYMYVcFASAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVM 425
Cdd:cd17325 285 ATSFWLLLLLLALLGLGLGLVF-PATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAAL 363
|
410
....*....|.
gi 1785684408 426 LLLCALVLSIF 436
Cdd:cd17325 364 LLLAAVLFLLL 374
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
62-139 |
3.18e-11 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 64.29 E-value: 3.18e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1785684408 62 FTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFI 139
Cdd:cd17379 38 FQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFV 115
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
60-431 |
3.62e-11 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 64.48 E-value: 3.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 60 AAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGAlIMVGYASFTEFI 139
Cdd:cd17372 37 ALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLGG-GPQLASWYLEFL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 140 PATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLawllsgkyFIESPRWLAgkgqiagaecqlre 219
Cdd:cd17372 116 PAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSSVPSSL--------LLVFYRWTP-------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 220 veqqierEKSIRLPPLTSYQSNSKVKVIkgtfwlLFKGEMLRRTLVAitvliamNISLYTITVWIPT-IFVNSGIDVDKS 298
Cdd:cd17372 174 -------KTTLLLWVIWFGNAFAYYGVV------LLTTELNNSHNVC-------GSKSDSDSGESPTeKQCRNSNDVDYR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 299 ILMTAVimIGAPVGIFIAALIIDHFPRRLFGSTLLIIIAVLGYIYSIQTTEwailiygLVMIFFLYMYVCFASA------ 372
Cdd:cd17372 234 DVFIAT--FAEFPGLLISAAMIDRLGRKASMASMLFTCCIFLLLLLICQSP-------FILTVLLFGGRACISAaftvvy 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1785684408 373 VYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYgVAALLTHYGSITVFMVLGVMLLLCAL 431
Cdd:cd17372 305 IYTPEVYPTAVRALGVGTGSSVGRIGAILCPF-IAQVLVHGSQTIALLLFSVVCLVSAI 362
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
46-450 |
2.51e-10 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 62.40 E-value: 2.51e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 46 AKLVSNGWSNNFLNAAFTSALMfGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFV---------PDMYWLI-- 114
Cdd:PRK10077 45 PQNLSESAANSLLGFCVASALI-GCIIGGALGGYCSNRFGRRDSLKIAAVLFFISALGSAWPefgftsigpDNTGYVPef 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 115 -FFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFV----------GNWSPMLSAAIGVVVIafFSWRIMFLLGG 183
Cdd:PRK10077 124 vIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFNQFAiifgqlvvyfVNYFIARSGDASWLNT--DGWRYMFASEA 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 184 IGILLAWLLSgkYFI-ESPRWLAGKGQIAGAECQLREVEQQIEREKSirlppLTSYQSNSKVKVIKGTFWLLFkGEMLRR 262
Cdd:PRK10077 202 IPALLFLMLL--YFVpETPRYLMSRGKQEQAEGILRKIMGNTLATQA-----LQEIKHSLDHGRKTGGKLLMF-GVGVIV 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 263 TLVAITVL---IAMNISLYtitvWIPTIFVNSGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRRlfgstLLIIIAVL 339
Cdd:PRK10077 274 IGVMLSVFqqfVGINVVLY----YAPEIFKTLGASTDIALLQTIIVGVINLTFTVLAIMTVDKFGRK-----PLQIIGAL 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 340 GY---IYSIQTTEWAILIyGLVMIFFLYMYVCFASA-------VYIPELWPTHLRLRGSGFVNAVGRIVAVFTP------ 403
Cdd:PRK10077 345 GMaigMFSLGTAFYTQAP-GIVALLSMLFYVAAFAMswgpvcwVLLSEIFPNAIRGKALAIAVAAQWIANYFVSwtfpmm 423
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 1785684408 404 YGVAALLTHYGSITVFMVLGVMLLLCALVLSIFGIETRKVSLEEISE 450
Cdd:PRK10077 424 DKNSWLVAHFHNGFSYWIYGCMGVLAALFMWKFVPETKGKTLEEMEA 470
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
23-189 |
6.26e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 60.71 E-value: 6.26e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 23 IFGIISFSLLLTGFLSYSGNVVLAKLVSNGWSNNFLNAAFTsalmFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAAT 102
Cdd:cd06173 214 LLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFG----VGALLGALLLGRLSKRRRRGRLLLIGALLLGLALL 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 103 GAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLG 182
Cdd:cd06173 290 VLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLA 369
|
....*..
gi 1785684408 183 GIGILLA 189
Cdd:cd06173 370 GALLLLA 376
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
55-439 |
7.17e-10 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 60.28 E-value: 7.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 55 NNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYAS 134
Cdd:cd17315 32 STSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLY 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 135 FTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFS--WRIMFLLGGIGILLAWLLsGKYFIESPRWLAGKGqiag 212
Cdd:cd17315 112 ISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPgwWRLMFALAAVPALLQLLL-MFFLPESRALLVGVG---- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 213 aecqlreveqqiereksirlppltsyqsnskvkvikgtfwllfkgemlrrtLVAITVLIAMNISLYtitvWIPTIFVNSG 292
Cdd:cd17315 187 ---------------------------------------------------LQLLQQLTGINAVMY----YAPTIFKSAG 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 293 iDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRR--LFGSTLLIIIAVLGYIYSIQTTEWAILIYGLVMIFFLYMYVCFA 370
Cdd:cd17315 212 -GGTASILASIIVGVVNLLATLVAIRLVDKVGRRplLLIGFAGMAASLLLLAIAFLLPALAKAAGWLALLGILLYIAAFA 290
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1785684408 371 ------SAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVMLLLCALVLSIFGIE 439
Cdd:cd17315 291 mgagpvPWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVGLTFLIMVSTIGLAGVFIFFAAVCLLALVFVFFFVPE 365
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
18-432 |
1.03e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 59.87 E-value: 1.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 18 RFHYRIFGIISFSLLLTGFLSYSGNVVLAKLVSNGWSNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIV 97
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 98 GIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYAsfteFIPATVRGKWSARLSFVGNWSPmLSAAIGVVVIAFF---- 173
Cdd:COG0738 84 ALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANP----YVAALGPETAASRLNLLHAFFS-LGALLGPLLGGLLillg 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 174 ---SWRIMFLLGGIGILLAWLLSGKyfiesprwlagkgqiagaecqlreveqqiereksIRLPPLTSYQSNSKVKVIKGT 250
Cdd:COG0738 159 lslSWHLPYLILAVLLLLLALLFLR----------------------------------SKLPEIEEEEEEAAGSAASLK 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 251 FWLLFkgemlRRTLVAITVLIAMNISLYTITVWIPTIFVNS-GIDVDKSILMTAVIMIGAPVGIFIAALIIDHF-PRRLF 328
Cdd:COG0738 205 SLLKN-----PRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVlGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFgPVRLL 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 329 gsTLLIIIAVLGYIYSIQTTEWAILIYGLVMIFFlymyvcFASAVY------IPELWPTHLRLRGSGFVnAVGRIVAVFT 402
Cdd:COG0738 280 --RLSALLAAVGLLLALLAPGPWLALIGLALVGL------GLSLMFptifslALDGLGKRTAAAVSAVL-IMGIVGGAIG 350
|
410 420 430
....*....|....*....|....*....|
gi 1785684408 403 PYGVAALLTHYGSITVFMVLGVMLLLCALV 432
Cdd:COG0738 351 PPLIGFLADAFGLRAAFLVPLVCYLLILLL 380
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
2-287 |
1.11e-09 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 60.76 E-value: 1.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 2 EQYDQIgarLDRLPLARFHYRIFGIISFSLLLTGFLSYSGNVVLAKLVSNGWSNNFLNAAFTSALMFGYFIGSLTGGFIG 81
Cdd:TIGR01299 150 QQYELI---IQECGHGRFQWALFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLA 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 82 DYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGK---WSARLSFVGNws 158
Cdd:TIGR01299 227 DKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEhlsWLCMFWMIGG-- 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 159 pMLSAAIGVVVI-------------AFFSWRIMFLLGGIGILLAwLLSGKYFIESPRWLAGKGQIAGAECQLREVEQQIE 225
Cdd:TIGR01299 305 -IYAAAMAWAIIphygwsfqmgsayQFHSWRVFVIVCAFPCVFA-IGALTFMPESPRFFLENGKHDEAWMILKLIHDTNM 382
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 226 REKS----------IRLP----PLTSYQSN-------------SKVKVIKGTFWLLFKGEMLRRTLVAITVLIAMNISLY 278
Cdd:TIGR01299 383 RAKGhpekvfsvnhIKTIhqedELIEIESDtgtwyqrcfvralSEGGGIWGNFLRCFNPEVREITIKLMGVWFTLSFGYY 462
|
....*....
gi 1785684408 279 TITVWIPTI 287
Cdd:TIGR01299 463 GLSVWFPDM 471
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
72-437 |
2.29e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 58.74 E-value: 2.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 72 IGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARL 151
Cdd:cd17473 50 LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQ 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 152 SFVGNWSPMLSAAIGvVVIAFFSWRIMFLLGGIGILLAWLLSgkyfiesprwlagkgqiagaecqlreveqqiereKSIR 231
Cdd:cd17473 130 SAAMSLGGVVFLLLG-GALAEIGWRAPFLVYLLALPVLILVL----------------------------------LFLP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 232 LPPLTSYQSNSKVKVIKGTFwllfkgeMLRRTLVAITVLIAMNISLYTITVWIPTIFVNSGIDVDKSI-LMTAVIMIGAP 310
Cdd:cd17473 175 EPARKSKSAASPGAATAAAL-------PWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIgLALAIASLAGA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 311 VGIFIAALIIDHFPRRLFGSTLLIIIAvLGYIYSIQTTEWAILIYGLVMIFFLYMYVCFASAVYIPELWPTHLRLRGSGF 390
Cdd:cd17473 248 IGALLFGRLKRRLGKRRLLAIGFALMA-LGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGI 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1785684408 391 VNAVGRIVAVFTPYGVAALLTHYGSIT-VFMVLGVMLLLCALVLSIFG 437
Cdd:cd17473 327 VTSAFFLGQFLSPLVLGPLVNLTGGLSgAFLILGVLALVLAIVLLLLR 374
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
64-432 |
2.41e-09 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 58.82 E-value: 2.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 64 SALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATV 143
Cdd:PRK11551 57 SAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRL 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 144 RGK----WSARLSFVGnwspMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWLLSGKYFIESPRWLAGKGQIAGAEcqlre 219
Cdd:PRK11551 137 RGTavslMYCGVPFGG----ALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESRAFAQAAGAGKQRA----- 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 220 veqqiereksirlppltsyqsnskvkvikGTFWLLFKGEMLRRTLVAITVLIAMNISLYTITVWIPTIFVNSGIDVDKSI 299
Cdd:PRK11551 208 -----------------------------PVLRALFGEGRATATLLLWISYFFTLIVLYFLLNWLPSLLVGQGLSRSQAG 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 300 LMTAVIMIGAPVGIFIAALIIDHFPRRLfgSTLLI---IIAVLGyIYSIQTTEWAILIYGLVMIFFLymyVCFASAVY-- 374
Cdd:PRK11551 259 LVQIAFNIGGALGSLLIGALMDRLRPRR--VVLLIyagILASLA-ALAAAPSFAGMLLAGFAAGLFV---VGGQSVLYal 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1785684408 375 IPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALL-THYGSITVFMVLGVMLLLCALV 432
Cdd:PRK11551 333 APLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQLLaLGRSTVGVIGASIPVILVAALA 391
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
65-193 |
4.08e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 57.95 E-value: 4.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 65 ALMFGYFIgsLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVR 144
Cdd:cd17321 41 LLAFAALL--LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERR 118
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1785684408 145 GKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWLLS 193
Cdd:cd17321 119 GRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLA 167
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
62-448 |
5.79e-09 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 57.75 E-value: 5.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 62 FTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPA 141
Cdd:cd17362 44 VVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPS 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 142 TVRGKWSARLSFVGNWSPMLSAAIGVVVI-AFFSWRIMFllgGIGILLAWLLS-GKYFI-ESPRWlagkgqiagaecqlr 218
Cdd:cd17362 124 HIRGLLVSLKELFIVLGILLGYVSGYAFAdVVGGWRYMY---GLAAPPALLLGiGMWFLpPSPRW--------------- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 219 eveqqiereksirlppltsyqsnskvkvikgtfwllfKGEMLRRTLVAITVLIAMNIS-LYTITVWIPTIFVNSGIDVDK 297
Cdd:cd17362 186 -------------------------------------QGNYRKPLIIGLGLVLFQQITgQPSVLYYAATIFKSAGFSAAS 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 298 SILMTAVImigapVGIF------IAALIIDHFPRR--LFGSTLLIIIAVLGYIYSIQTTEWAILIYGLVMIFFLYMYV-C 368
Cdd:cd17362 229 DATLVSVG-----LGVFkllmtiVAVLLVDKLGRRplLLGGVSGMVVSLFLLAAYNLFVQMGPAGLAWLSLVALLLYVgA 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 369 FA------SAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVMLLLCALVLSIFGIETRK 442
Cdd:cd17362 304 YQisfgpiSWLMVSEIFPLRVRGRAIALAVLVNFGSNALVSLAFLPLQELIGLPGTFLGFGVIGVLALLFIYFTVPETKG 383
|
....*.
gi 1785684408 443 VSLEEI 448
Cdd:cd17362 384 LSLEEI 389
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
54-441 |
6.89e-09 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 57.69 E-value: 6.89e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 54 SNNFLNAAFTSALMF--GYF---IGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDM----YW----LIFFRFLM 120
Cdd:cd17367 32 SGDPTVALLSTAAVFavGFLmrpIGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYatigIWapiiLLLARLLQ 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 121 GTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFS--------WRIMFLLGGIGILLA-WL 191
Cdd:cd17367 112 GLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHTLGedqmaawgWRIPFLLGGVLAVVVlWL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 192 LSGkyfiesprwlagkgqiagaecqLREVEQQIEREKSIRLPPLTsyqsnskvkvikgtfWLLFKGEMlRRTLVAITVLI 271
Cdd:cd17367 192 RRG----------------------LEETESFEAIAESNEASAGT---------------LRELRRHP-RELLLVVGLTA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 272 AMNISLYTITVWIPTIFVNS-GIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRRlfgsTLLIIIAVLGYIYSI----- 345
Cdd:cd17367 234 GGTLAFYTWTTYLQKFLVNTaGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRR----PLLLFFGIGGTLATVpllsa 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 346 ---QTTEWAILIYGLVMIFFLYMYVCFaSAVYIPELWPTHLRLRGSGFVNAVGriVAVF---TPYgVAALLTHYGSITVF 419
Cdd:cd17367 310 ldhTDSPYTAFALVLVGLVFLSGYTSI-NAVVKAELFPTHVRALGVGLPYALA--VAIFggtAPY-VALWLKSIGHEWVF 385
|
410 420
....*....|....*....|..
gi 1785684408 420 MVLGVMLLLCALVLSIFGIETR 441
Cdd:cd17367 386 FWYVAGLIAISLVVYLRMPETR 407
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
64-435 |
2.06e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 56.02 E-value: 2.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 64 SALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATV 143
Cdd:cd17324 41 SAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 144 RGKWSARL---SFVGNwspMLSAAIGVVVIAFFSWRIMFL-LGGIGILLAWLLsgkyfiesprwlagkgqiagaecqlre 219
Cdd:cd17324 121 RGRAIGLVfsgLTLGL---VLGRPLGGLLGQLLGWRAAFLaIAVLALLAALLL--------------------------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 220 veqqierekSIRLPPLTSyqSNSKVKVIKGTFWLLFKGEMLRRTLVAITVLIAMNISLYTITVwiPTIFVNSGIDVDKSI 299
Cdd:cd17324 171 ---------WRLLPSLPP--KKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLA--PFLTDVPGFSSSAII 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 300 LMTAVIMIGAPVGIFIAALIIDHFPRR-LFGSTLLIIIAVLGYIYSIQTTEWAILIYGLVMIFFLYMYVCFASAVYipEL 378
Cdd:cd17324 238 GLLLLFGVAGVVGSPLAGRLADRGGRRaLLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVL--RL 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1785684408 379 WPTHlRLRGSGFVNAVGRI-VAVFTPYGvAALLTHYGSITVFMVLGVMLLLcALVLSI 435
Cdd:cd17324 316 APEA-RGLASSLYLAAYNLgGALGAALG-GLVLDHGGWAGVGWVGAALLLL-ALLLAL 370
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
20-436 |
5.90e-08 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 54.59 E-value: 5.90e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 20 HYRIFGIISFSLLLTGFLSYSGNVVLAKLVSNGWSNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGI 99
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 100 AATGAAFVpdmYWLIFFRFLMGtgmgaliMVGYASFTEFIPATV----------RGKWSARLSFVGNWSPMLSAAIGVVV 169
Cdd:cd17312 81 ANIFMGFS---TSLWFFAVLWG-------LNGLFQSMGWPPCVKllgnwfskkeRGTVYGIWSTSHNFGGILAPILAASL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 170 IAFFSWRIMFLLGGIGILLAWLLSGKYFIESPRWLagkgqiagaecqlreveqqiereksirlppltsyqsnskvkvikg 249
Cdd:cd17312 151 ASYYGWRAAFLVPGIVGLVVAIILFFFLRDSPPYV--------------------------------------------- 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 250 tfWLLfkgemlrrtlvaITVLIAMNISLYTITVWIPTIFVNS-GID-VDKSILMTAVIMIGAPVGIFIAALIIDHFPRRL 327
Cdd:cd17312 186 --WVL------------SLAYAFVYIVRYACLDWGPLYLYEVkGYSlIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRR 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 328 FGSTLLIIIAVLGYIYSIQTTEWAILIYGLVMI---FFLYMYVCFASAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPY 404
Cdd:cd17312 252 APIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFligFFVGGPINLIGGAAAQDIGRKEAAGTATGFVGLFGYLGASLAGL 331
|
410 420 430
....*....|....*....|....*....|..
gi 1785684408 405 GVAALLTHYGSITVFMVLGVMLLLCALVLSIF 436
Cdd:cd17312 332 PLGYIIDHYGWSTVFYFLISAALLSVLLLLSL 363
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
35-433 |
8.33e-08 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 54.20 E-value: 8.33e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 35 GFLSYSGNVVLAKLVSNGWSNnflnAAFTSALMFGYFIGSLTGGFIG---DYFGRRRAFRINLLIVGIAATGAAFVPDMY 111
Cdd:cd17355 17 GIRYYFGVFIIPIIAEFGWSR----AVISLAFTVGLLAFGLAQPFVGrllDRFGPRRVMLLGLLLLAAGLVLLALATSLW 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 112 WLIFFRFLM-GTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAW 190
Cdd:cd17355 93 QLYLLWGLLgGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 191 LLSGKYFIESPRWLAGKGQIAGAECQLREVEQQIEREKSirlppltsyqsnskvkvikgtFWLLfkgemlrrtlvAITVL 270
Cdd:cd17355 173 VPVLLLLRRRPADLALRAYDDASPASPGSTLKEALRSAS---------------------FWLL-----------ALAFF 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 271 IAmNISLYTITVWIPTIFVNSGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRR--LFGSTLLIIIAVLGYIYSIQTT 348
Cdd:cd17355 221 LC-GFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRrlLAASYALRALGLALLLLLPFPP 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 349 EWAILIygLVMIFFLYMYVCFASAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVMLLL 428
Cdd:cd17355 300 LALLLF--AALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGL 377
|
....*
gi 1785684408 429 CALVL 433
Cdd:cd17355 378 IAALL 382
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
27-193 |
1.18e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 53.37 E-value: 1.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 27 ISFSLLLTGFLSYSGNVVLAKLVSNGWSNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAF 106
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 107 VPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGI 186
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
....*..
gi 1785684408 187 LLAWLLS 193
Cdd:cd17489 161 LLALLLV 167
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
55-436 |
1.64e-07 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 53.05 E-value: 1.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 55 NNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPD------MYWLIFFRFLMGTGMGALI 128
Cdd:cd17364 37 PSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGstplgvMGWLIFFRFLLGIGIGGDY 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 129 MVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFS--------------WRIMFLLGGIgillawllsg 194
Cdd:cd17364 117 PLSATIMSEYANKKRRGALIAAVFAMQGFGILAGAIVTLILSAIFEhplpagtyhhadlvWRIVLGLGAI---------- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 195 kyfiesprwlagkgqiagaecqlreveqqiereksirlPPLTSYqsnskvkvikgtfwllfkgeMLRRTLVAITVLIAM- 273
Cdd:cd17364 187 --------------------------------------PALSVL--------------------YFRKHLLGTAGTWFLl 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 274 NISLYTITVWIPTIF----VNSGIDVDKSILMTAVIMIGAPV-----GIFIAALIIDHFPRRLFGSTLLIIIAVLGYIYS 344
Cdd:cd17364 209 DIAFYGQNLFQSTIIsaigFSKTMNAYQELFNIAVGQLIIALagtvpGYWFTVFLIDRIGRKKIQMMGFFGMTIFLLILA 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 345 IQTTEWAILIYGLVMIFFLYMYVCFA-----SAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVF 419
Cdd:cd17364 289 GPYDHWKISTIGFFVLYGLTFFFSNFgpnttTFIVPAEVFPARVRSTCHGISAASGKIGAIVGSFLFLSLTQNIGVRNVL 368
|
410
....*....|....*..
gi 1785684408 420 MVLGVMLLLCALVLSIF 436
Cdd:cd17364 369 IILAGVALLGIILTLLF 385
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
68-285 |
1.67e-07 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 53.39 E-value: 1.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 68 FGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKW 147
Cdd:cd17438 45 LGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEH 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 148 SARLSFVGNWSPMLSAAIGVVVIA-------------FFSWRIMFLLGGIGIlLAWLLSGKYFIESPRWLAGKGQIAGAE 214
Cdd:cd17438 125 LSWLCMFWMIGGLYASAMAWSIIPhygwgfsmgtnyhFHSWRVFVIICALPC-IASIIALKFMPESPRFLLEMGKHDEAW 203
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1785684408 215 CQLREVEQQIEREKSIrlPPLTSYQSNSKVKvikgtfwllfkgemlrRTLVAITVLIAMNISLYTITVWIP 285
Cdd:cd17438 204 MILKNIHDTNMRAKGT--PEKVFTVSNIKRK----------------NTLFLAVVWFTMAFSYYGLTVWFP 256
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
58-193 |
2.48e-07 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 52.29 E-value: 2.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 58 LNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTE 137
Cdd:cd17374 36 LKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTE 115
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1785684408 138 FIPatvrGKWSARLSFVGnwspMLSAAIGVVVIA-----FFSWRIMFLLGGIGILLAWLLS 193
Cdd:cd17374 116 WTT----PRHRALAITLT----SCFFSIGQMLLAglayaIRDWRLLQLVVSVPFFLFFLYS 168
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
30-191 |
3.67e-07 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 52.25 E-value: 3.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 30 SLLLTGFLSYSGN---------VVLAKLVSNGWSNNFLNAAFTSALMFGYFIGSLTggfigDYFGRRRAFRINLLIVGIA 100
Cdd:PRK15402 17 CLVLFEFATYIANdmiqpgmlaVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLS-----DRIGRRPVMLAGVAFFILT 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 101 ATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFL 180
Cdd:PRK15402 92 CLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFV 171
|
170
....*....|.
gi 1785684408 181 LGGIGILLAWL 191
Cdd:PRK15402 172 LFAALAALSFF 182
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
72-433 |
4.44e-07 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 52.02 E-value: 4.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 72 IGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDM----YWLIFFRFLM---------GTGMGALIMVGyasftEF 138
Cdd:PRK10642 72 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYatigIWAPILLLLCkmaqgfsvgGEYTGASIFVA-----EY 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 139 IPATVRGkwsarlsFVGNW---------------SPMLSAAIGVVVIAFFSWRIMFL----LGGIGILLAWLLSgkyfiE 199
Cdd:PRK10642 147 SPDRKRG-------FMGSWldfgsiagfvlgagvVVLISTIVGEANFLDWGWRIPFFialpLGIIGLYLRHALE-----E 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 200 SPRWlagkgqiagaecQLREVEQQIEREKSIRLPPLTSYqsnskvKVIKGTFWllfkgemlRRTLVAITVLIAMNISLYT 279
Cdd:PRK10642 215 TPAF------------QQHVDKLEQGDREGLQDGPKVSF------KEIATKHW--------RSLLTCIGLVIATNVTYYM 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 280 ITVWIPTIFV-NSGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRRLF---GSTLLIIIAVLGYIYsIQTTEWAILIY 355
Cdd:PRK10642 269 LLTYMPSYLShNLHYSEDHGVLIIIAIMIGMLFVQPVMGLLSDRFGRRPFvilGSVALFVLAIPAFIL-INSNVIGLIFA 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 356 GLVMIFFLYMYVCFASAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITV----FMVLGVMLLLCAL 431
Cdd:PRK10642 348 GLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAWLVESTQNLMMpayyLMVVAVIGLITGV 427
|
..
gi 1785684408 432 VL 433
Cdd:PRK10642 428 TM 429
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
72-448 |
5.16e-07 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 51.63 E-value: 5.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 72 IGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARL 151
Cdd:cd17437 47 VGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFP 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 152 SFVGNWSPMLsaaiGVVVIAFFS-------WRIMFllgGIGILLAWLLS-GKYFI-ESPRWlagkgqiagaecqlreveq 222
Cdd:cd17437 127 EIFINIGILL----GYVSNYAFSglplhvgWRLML---GVGAVPSLFLAiGVLAMpESPRW------------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 223 qierEKSIRlppltsyqsnskvkvikgtfwllfkgemlRRTLVAITVLIAMNISLYTITVWI-PTIFVNSGI-DVDKSIL 300
Cdd:cd17437 181 ----TPAVR-----------------------------RMLIAALGIHFFQQASGIDAVVLYsPRIFKKAGIkSKDKLLL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 301 MTAVIMIGAPVGIFIAALIIDHFPRR--LFGST--LLIIIAVLGYIYSI-----QTTEWAIliygLVMIFFLYMYVCFAS 371
Cdd:cd17437 228 ATVAVGVTKTLFILVATFLLDKVGRRplLLTSTggMTLSLTALATSLTFidrngGGLTWAL----VLAITAVCSFVAFFS 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 372 A-------VYIPELWPTHLRLRGSGFVNAVGRIVAvftpyGVAAL--LTHYGSITV---FMVLGVMLLLCALVLSIFGIE 439
Cdd:cd17437 304 IgagpitwVYSSEIFPLRLRAQGASLGVVVNRLMS-----GTVSMtfLSMSKAITTggtFFLFAGVAAAAWVFFYFFLPE 378
|
....*....
gi 1785684408 440 TRKVSLEEI 448
Cdd:cd17437 379 TKGKSLEEI 387
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
21-449 |
5.85e-07 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 51.65 E-value: 5.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 21 YRIFgIISFSLLLTGFLSYSGNvvlAKLVSNgwsnnfLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIA 100
Cdd:TIGR00887 30 YDLF-CISLVTKMLGYVYYHGK---GPLPSS------VSAAVNGSASIGTLAGQLFFGWLADKLGRKRVYGMELIIMIIA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 101 ATGAAFVPD------MYWLIFFRFLMGTGMG------ALIMVGYAS----------------FTEFIPATVRGKWSARLS 152
Cdd:TIGR00887 100 TVASGLSPGsspksvMATLCFWRFWLGVGIGgdyplsAIITSEFATkkwrgammaavfamqgFGILAGAIVALIVLAGFK 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 153 FVGNWSPMLSAAIGVVVIAF-FSWRIMFLLGGIGILLAWllsgkYF----IESPRWLAGKG----QIAGAECQLREVEQQ 223
Cdd:TIGR00887 180 HSLEAAADEASCTGSCVPAVdYMWRILIGFGAVPALLAL-----YFrltiPETPRYTADVAkdveQAASDMSAVLQVKIE 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 224 IEREKSIRlppltsyqSNSKVKVIKGTFWLLFKGEMLRRT----LVAITVLIAMNISLYTITVWIPTIFVNSGI------ 293
Cdd:TIGR00887 255 AEPDEVEK--------ASTAVEVPKASWSDFFTHFFKWRHgkhlLGTAGSWFLLDIAFYGVNLNQKVILSAIGYsppaat 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 294 DVDKSILM------TAVIMIGAPVGIFIAALIIDH---FPRRLFGSTLL-IIIAVLGYIYSIQTTEWAILIYglVMIFFL 363
Cdd:TIGR00887 327 NNAYEELYktavgnLIIALAGTVPGYWVTVFLVDIigrKPIQLMGFFILtVLFFVLGFAYNHLSTHGFLAIY--VLAQFF 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 364 YMYVCFASAVYIP-ELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTH----YGSITVFMVLGVMLLLCALVL----- 433
Cdd:TIGR00887 405 ANFGPNATTFIVPgEVFPTRYRSTAHGISAASGKAGAIIGQFGFLYLAQHgdptKGYPTGIWMGHVLEIFALFMFlgilf 484
|
490
....*....|....*.
gi 1785684408 434 SIFGIETRKVSLEEIS 449
Cdd:TIGR00887 485 TLLIPETKGKSLEELS 500
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
259-412 |
7.38e-07 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 51.20 E-value: 7.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 259 MLRRTLVAITVLIAMNISLYTITVWIPTIFVNS-GIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRR---LFGSTLLI 334
Cdd:cd17366 191 LRRPLLICIGLVLVFNVTNYMLLSYMPSYLEETlGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKpvyAAGLAGLL 270
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1785684408 335 IIAVLGYIYSIQTTEWAILIYGLVMIFFLYMYVCFASAVyIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTH 412
Cdd:cd17366 271 VLAVPAFLLMNSGSIAAIFIGLLVLGLLLSCYTATMAST-LPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVS 347
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
63-203 |
1.19e-06 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 50.35 E-value: 1.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 63 TSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPAT 142
Cdd:cd17360 41 VSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPR 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1785684408 143 VRGKWSARLSFVGNWSPMLSAAI-GVVVIAFFSWRIMFLLGGIGILLAwlLSGKYFI-ESPRW 203
Cdd:cd17360 121 IRGRLVTINVLFITGGQFVAYVInGAFSYLPGGWRWMLGLAAVPAVLQ--FIGLLFLpESPRW 181
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
69-285 |
1.23e-06 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 50.57 E-value: 1.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 69 GYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWS 148
Cdd:cd17363 46 GMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 149 ARLSFVGNWSPMLSAAIGVVVIA-------------FFSWRIMFLLGGIGILLAwLLSGKYFIESPRWLAGKGQIAGAEC 215
Cdd:cd17363 126 SWLCMFWMIGGLYASAMAWAIIPhygwgfsmgtayqFHSWRVFVIVCALPSVAS-VVALTFMPESPRFLLEVGKHDEAWM 204
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1785684408 216 QLREVeqqiereksirlppltsYQSNSKVkviKGTFWLLFKGEMLRR--TLVAITVLIAMNISLYTITVWIP 285
Cdd:cd17363 205 ILKQV-----------------HDTNMRA---KGHPERVFTVSHIKRmnTLFLAIVWFTMSFSYYGLTVWFP 256
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
57-433 |
1.36e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 50.25 E-value: 1.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 57 FLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFT 136
Cdd:cd17477 31 ALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLN 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 137 EFIPATVRGKWSARLSFVGnwspMLSAAIGVVVIAFFSWR--IMFLLGGIGILLAWLLSGKYFIESPRwlagkgqiagae 214
Cdd:cd17477 111 ALATNENRGRVLGLYSTVL----GLGFALGPLLLALVGTAgaLPFLIAAVLLLLALVPLLLTRRAAPE------------ 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 215 cqlREVEQQIEREKSIRLPPLtsyqsnskvkvikgtfwllfkgemlrrTLVAITVLIAMNISLYTItvwIPTIFVNSGID 294
Cdd:cd17477 175 ---IEEAESISLRRLLRIAPL---------------------------ALLGAFVAGFLEGAFYSL---LPLYGLRLGLS 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 295 VDKSILMTAVIMIGAPVGIFIAALIIDHFPRR--LFGSTLLIIIAVLGYIYSIQTTEWAILIYGLVMIFFLYMYVCfaSA 372
Cdd:cd17477 222 VAQAALLLAAFVLGGLLLQWPLGWLADRFDRRrvLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTL--AL 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1785684408 373 VYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVMLLLCALVL 433
Cdd:cd17477 300 ALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
68-285 |
2.22e-06 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 49.64 E-value: 2.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 68 FGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKW 147
Cdd:cd17439 45 LGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEH 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 148 SARLSFVGNWSPMLSAAIGVVVI-------------AFFSWRIMFLLGGIGILLAwLLSGKYFIESPRWLAGKGQIAGAE 214
Cdd:cd17439 125 LSWLCMFWMIGGIYASAMAWAIIphygwsfqmgsayQFHSWRVFVLVCAFPSVFA-IGALTTMPESPRFFLENGKHDEAW 203
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1785684408 215 CQLREVeqqiereksirlppltsYQSNSKVkviKGTFWLLFKGEMLRR--TLVAITVLIAMNISLYTITVWIP 285
Cdd:cd17439 204 MVLKQV-----------------HDTNMRA---KGHPERVFSVTHIKRriTLMMMAVWFTMSFSYYGLTVWFP 256
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
78-192 |
2.90e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 49.11 E-value: 2.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 78 GFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNW 157
Cdd:cd17503 52 GWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILL 131
|
90 100 110
....*....|....*....|....*....|....*....
gi 1785684408 158 SPMLSAAIGVVVIAFFSWRIMFL----LGGIGILLAWLL 192
Cdd:cd17503 132 APAIGPTLGGWLTDNLSWRWIFYinlpIGILALLLAPLL 170
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
64-144 |
3.39e-06 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 48.95 E-value: 3.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 64 SALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATV 143
Cdd:cd17446 40 SIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMPTRV 119
|
.
gi 1785684408 144 R 144
Cdd:cd17446 120 R 120
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
78-202 |
5.23e-06 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 48.37 E-value: 5.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 78 GFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMgtGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNW 157
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQ--GSGAISSVVMALLADLTREENRTKAMALIGASIGI 130
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1785684408 158 SPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWLLSGKYFIESPR 202
Cdd:cd17472 131 AFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPK 175
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
78-433 |
5.33e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 48.34 E-value: 5.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 78 GFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALI-----MVGyASFTEFIPATVRGKWSARLS 152
Cdd:cd17474 55 GVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGplaltLIG-DLFEGGERAKAMGLYEAALG 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 153 FVGNWSPMLSAAIGVvviafFSWRIMFLLGGIGILLAWLLSGKYFIESPRwlagkgqiagaecqlreveqqiereksirl 232
Cdd:cd17474 134 LGIAVGPLLGGLLAA-----ISWRYPFFLLAALIPVAFLAILFLLPEPKE------------------------------ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 233 ppltsyqsnsKVKVIKGTFWLLFKGEMLRRTLVAITVLIAM-NISLYTITVWIPTIFVNSgidVDKSILMTAVIMIGAPV 311
Cdd:cd17474 179 ----------KAKSSSATKLRDLKKALRGRGLLTFLVSAFLyFFLYFAFLTYLPFLLELL---YGISPIIIGLLFAGWSV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 312 GIFIAALIIDHFPRRLFGSTLLIIIAVLGYIYSIQtteWAILIYGLVMIFFLYMYVCFASAVYIP-------ELWPTHLR 384
Cdd:cd17474 246 LLALGSLFVGRLLKKRFGARRILVIGLLLYALSLL---LLGFVPSLALLLIAIVLFGLGLGLNLPllttlvtELAPEEER 322
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1785684408 385 LRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVMLLLCALVL 433
Cdd:cd17474 323 GTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLL 371
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
60-192 |
5.41e-06 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 48.54 E-value: 5.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 60 AAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDmYWLIF-FRFLMGTGMGALIMVGYASFTEF 138
Cdd:PRK03893 58 ASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPG-YWTLFiARLVIGMGMAGEYGSSATYVIES 136
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1785684408 139 IPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWLL 192
Cdd:PRK03893 137 WPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFFIGILPIIFALWL 190
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
60-193 |
9.83e-06 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 47.50 E-value: 9.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 60 AAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGAlIMVGYASFTEFI 139
Cdd:cd17441 37 ALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIGG-VPQSVTLYAEFL 115
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1785684408 140 PATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWLLS 193
Cdd:cd17441 116 PMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSALPLLIFAVLC 169
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
72-191 |
1.28e-05 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 47.37 E-value: 1.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 72 IGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARL 151
Cdd:TIGR00711 52 ISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIW 131
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1785684408 152 SFVGNWSPMLSAAIGVVVIAFFSWRIMFLL----GGIGILLAWL 191
Cdd:TIGR00711 132 GLTVLVAPALGPTLGGWIIENYHWRWIFLInvpiGIIVVVVAFF 175
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
64-436 |
1.56e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 46.93 E-value: 1.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 64 SALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYasftefipatv 143
Cdd:cd17333 38 SSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGAN----------- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 144 rgkwsarlSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWLLSGKYfiesPRWLAGKGQIAGAECQLReveqq 223
Cdd:cd17333 107 --------TFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSW----AYLIIGLIYLLLAILILL----- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 224 iereksirlpPLTSYQSNSKVKVIKGTFWLLFKGEMLRRTLVAITVLIAM--NISLYTITVWIPTIFVNS-GIDVDKSIL 300
Cdd:cd17333 170 ----------TLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFlyVGAETAFSSWVPSYLVEKkHVSDGLAGY 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 301 MTAVIMIGAPVGIFIAALIIDHFPRRLFgSTLLIIIAVLGYIYSIQTTEWAILIYGLVMIFFLyMYVCFASAVYIPELWP 380
Cdd:cd17333 240 LLSGFWVGITIGRLLGGPISRRIKPHTL-LVLSGSGALLGLLILLLAPTLVVGLVATALLGLF-MAALFPTILSLGISNL 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1785684408 381 THLRLRGSGFVNAVGRIVAVFTPYgVAALLTHYGSITVFMVLGVMLLLCALVLSIF 436
Cdd:cd17333 318 PYAKGKGTSVLLAAGSIGGAIIPF-IMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
64-191 |
2.47e-05 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 46.22 E-value: 2.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 64 SALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATV 143
Cdd:TIGR00710 47 TLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEE 126
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1785684408 144 RGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMF-LLGGIGILLAWL 191
Cdd:TIGR00710 127 LSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFaFLSLAGILLSAL 175
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
265-452 |
2.79e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.87 E-value: 2.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 265 VAITVLIAMNISLYTITVWIPTIFVNSGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRRLFGSTLLIIIAVLGYIYS 344
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 345 IQTTEWAILIYGLVMIFFLYMYVCfASAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGV 424
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFP-AALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
170 180
....*....|....*....|....*...
gi 1785684408 425 MLLLCALVLSIFGIETRKVSLEEISEVN 452
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEAR 187
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
60-433 |
2.81e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.07 E-value: 2.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 60 AAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPD-----MYWLIFFRFLMGTGMGALIMVGYAS 134
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALlgslsLWLLLVLAFLLGIASAFFGPARQAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 135 FTEFIPATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWLLSgkyfiesprwlagkgqiagae 214
Cdd:cd06173 117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLL--------------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 215 CQLREVEQQIEREKSirlppltsyqsNSKVKVIKGTFWLLFKGEMLRRTLVAITVLIAMNISLYTITVwiPTIFVNSGID 294
Cdd:cd06173 176 LFIRRPPPAAPGESS-----------SLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLP--LLAKEVLGGG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 295 VDKSILMTAVIMIGAPVGIFIAALIIDHFPRRLFGSTLLIIIAVLGYIYSIqTTEWAILIYGLVMIFFLYMYVCFASAVY 374
Cdd:cd06173 243 AAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL-SPSLWLLLAALFLLGLAGGLFNVPLNTL 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1785684408 375 IPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVMLLLCALVL 433
Cdd:cd06173 322 LQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLL 380
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
68-436 |
2.98e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 46.07 E-value: 2.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 68 FGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKW 147
Cdd:cd17329 46 VAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRA 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 148 SARLSFVGNWSPMLSAAIG-VVVIAFFSWRIMFLLGGIGILLAWLLsgkyfiesprwlagkgqiagaecqlreveqqier 226
Cdd:cd17329 126 FSLLYWAINLGVAIGPLLGgLLLLYSFRLLFLAAAVLFLLAALVLL---------------------------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 227 eksIRLPPLTSYQSNSKVKVIKGTFWLLFKGEMLRRTLVAITVLIAMNISLYTItvwIPTIFVNSGIDVDKsilMTAVIM 306
Cdd:cd17329 172 ---FLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLEST---LPVYVVEILGLGES---LLGLLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 307 IGAPVGIFIAALIIDHFPRRlFGSTLLIIIAVLGYIYSIQTTEWAILIYGLVMIFFLY----MYVCFASAVYIPELWPTH 382
Cdd:cd17329 243 ALNALLIVLLQFPVARLVER-FRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLtlgeMLVFPAVQTLVAALAPPD 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1785684408 383 LRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVMLLLCALVLSIF 436
Cdd:cd17329 322 KRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
63-193 |
4.47e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 45.64 E-value: 4.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 63 TSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPAT 142
Cdd:cd17323 40 VSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPE 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1785684408 143 VRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWLLS 193
Cdd:cd17323 120 ERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILI 170
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
78-193 |
4.61e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 45.26 E-value: 4.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 78 GFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMgALIMVGYASFTEFIPATVRGKWSARLSFVGNW 157
Cdd:cd17504 52 GRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGG-AVFPLAFALVREEFPPERVPVAQGILSATFGI 130
|
90 100 110
....*....|....*....|....*....|....*.
gi 1785684408 158 SPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWLLS 193
Cdd:cd17504 131 GAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALV 166
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
69-200 |
4.87e-05 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 43.02 E-value: 4.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 69 GYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWS 148
Cdd:TIGR00880 10 GQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVAL 89
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1785684408 149 ARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWLLSGKYFIES 200
Cdd:TIGR00880 90 GLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
260-436 |
5.70e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.96 E-value: 5.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 260 LRRTLVAITVLIAMNISLYTITVWIPTIFVNSGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRRLFGSTLLIIIAVL 339
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 340 GYIYSIQTTEWAILIYGLVMIFFLYMYVcFASAVYIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSITVF 419
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLGAGALF-PAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170
....*....|....*..
gi 1785684408 420 MVLGVMLLLCALVLSIF 436
Cdd:COG2814 168 LVNAVLALLALLLLLRL 184
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
78-433 |
5.97e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.85 E-value: 5.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 78 GFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATvRGKWSARLSFVGNW 157
Cdd:cd17478 52 GYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGR-RGLAMSIFSVGGNL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 158 SPMLSAAIGVVVIAFF---SWRIMFLLGGIGILLAWLLSGKYFIESPRWLAGKGQIAgaecqlreveqqiereksirlpp 234
Cdd:cd17478 131 GFALGPLIAAALVALFgglGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSAR----------------------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 235 ltsyqsnSKVKVIKGTFWLLFKGEMLRrtlvaitvliamNISLYTITVWIPTIFVNSGIDVDKSILMTAVIMIGAPVGIF 314
Cdd:cd17478 188 -------STLKGVWRALLLLLIIVFLR------------SWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 315 IAALIIDHFPRR--LFGSTLLIIIAVLGYIYsiqTTEWAILIygLVMIFFLYMYVCF-ASAVYIPELWPTHLRLrGSGFV 391
Cdd:cd17478 249 IGGPLSDRFGRRrvIIASLLLAAPFLLLFLL---TPGIWSYI--LLVLAGFLLFASFpVTVVLAQELLPGNVGL-ASGLM 322
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1785684408 392 NAVGRIVAVFTPYGVAALLTHYGSITVFMVLGVMLLLCALVL 433
Cdd:cd17478 323 MGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLA 364
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
5-189 |
6.41e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 44.87 E-value: 6.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 5 DQIGARLDRLPLARFHYRIFGIISFS-----LLLTGFLSYSGNVVLAKLVSNGWSNNFLNAAFTSALMFGYFIgslTGGF 79
Cdd:cd17474 181 KSSSATKLRDLKKALRGRGLLTFLVSaflyfFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLF---VGRL 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 80 IGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSP 159
Cdd:cd17474 258 LKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQ 337
|
170 180 190
....*....|....*....|....*....|
gi 1785684408 160 MLSAAIGVVVIAFFSWRIMFLLGGIGILLA 189
Cdd:cd17474 338 AVGPLLFGLLLEIFGLSAPFLVGAAIALAA 367
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
63-414 |
6.41e-05 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 45.06 E-value: 6.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 63 TSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPAT 142
Cdd:TIGR00881 36 LSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRS 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 143 VRGKWSARLSFVGNWSPMLSAAIGVVVIAFF-SWRIMFLLGGIGILLAWLLSGKYFIESPRwlagkgqiagaECQLREVE 221
Cdd:TIGR00881 116 ERGTWVSFWNCSHNVGGGLLPPLVLFGIAELySWHWVFIVPGIIAIIVSLICFLLLRDSPQ-----------SCGLPPAE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 222 QQIEREKSIRLPpltsyQSNSKVKVIKGTFWLLFKGEMLrrtLVAITVLIAMNISLYTITVWIPTIFVNS-GIDVDKSIL 300
Cdd:TIGR00881 185 EMPNEEPDGDAE-----KKEEELTKKQIFLQYVLLNKVL---WYISLGYVFVYVVRTGILDWSPLYLTQEkGFSKEKASW 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 301 MTAVIMIGAPVGIFIAALIIDHF---PRRLFG--STLLIIIAVLGYIYSIQTTEWAILIYGLVMIFFLYMYVCFASaVYI 375
Cdd:TIGR00881 257 AFTLYELGGLVGTLLAGWLSDKLfngRRGPLAvfFMALIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPQMLIG-VIA 335
|
330 340 350
....*....|....*....|....*....|....*....
gi 1785684408 376 PELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYG 414
Cdd:TIGR00881 336 SELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
78-181 |
7.68e-05 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 44.48 E-value: 7.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 78 GFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNW 157
Cdd:cd17502 51 GKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGI 130
|
90 100
....*....|....*....|....
gi 1785684408 158 SPMLSAAIGVVVIAFFSWRIMFLL 181
Cdd:cd17502 131 ASVAGPLIGGAFTDHLSWRWCFYI 154
|
|
| MFS_SLC22A16_CT2 |
cd17375 |
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ... |
66-206 |
9.97e-05 |
|
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340933 [Multi-domain] Cd Length: 341 Bit Score: 44.36 E-value: 9.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 66 LMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRG 145
Cdd:cd17375 44 FMLGVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGIAVAFTFDYYSFVIVRFLLAMVSSGYLVVVFVYVTEFTGIKART 123
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1785684408 146 KWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIG-ILLAWLLSGKYFIESPRWLAG 206
Cdd:cd17375 124 WASMHVHAFFAVGIMVVALVGYLVRTWWIYQIILSLVTIPfILCCWMLPKRTITVWLIWFTG 185
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
63-375 |
1.51e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 43.76 E-value: 1.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 63 TSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPAT 142
Cdd:cd17328 40 QTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKE 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 143 VRGKWSARLSFVGNWSPMLSAAIG-VVVIAFFSWRIMFLL-GGIGILLAWLLsgKYFIESPRwlagKGQIAGAECQLREV 220
Cdd:cd17328 120 KRTRALGVFYFAIPLGSGLGYVVGgLVAQATGGWRWAFRVtGVLGVLLAILL--LLFVREPP----RGAAEGGVMAKSTA 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 221 eqqiereksirlpplTSYQSNSKVKVIKGTFWLLFKGemlrrtlvaitvLIAMNISLYTITVWIPTIF-----VNSGIDV 295
Cdd:cd17328 194 ---------------TSFLADLKALAKNPSFILSTLG------------FTAVSFVTGALAFWAPTFFlrafgVGDLSSA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 296 DKSILMTAVIMIGAPVGIFIAALIIDHFPRR------------LFGSTLLIIIAVLGYIYSIqtteWAILIYGLVMIFFL 363
Cdd:cd17328 247 DVGLIFGAITCIAGVLGVLLGGILADRLRRKtpradplvcavgLLAAAPFLFLALVLALSNL----LLAWVLLFLGEFLL 322
|
330
....*....|....
gi 1785684408 364 YMY--VCFASAVYI 375
Cdd:cd17328 323 SLNwaPVFAILLYV 336
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
9-156 |
2.60e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.04 E-value: 2.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 9 ARLDRLPLARFHYRIFGIISFSLLLTGFLSYSGNVVLAKLVSN--GWSNNFLnAAFTSALMFGYFIGSLTGGFIGDYFGR 86
Cdd:COG2814 194 ARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvlGLSASAA-GLLLALFGLGGVLGALLAGRLADRFGR 272
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 87 RRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGN 156
Cdd:COG2814 273 RRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFF 342
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
64-327 |
2.73e-04 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 42.99 E-value: 2.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 64 SALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAA-----TGAAFVPDMywLIFFRFLMGTGMGALIMVGYASFTEF 138
Cdd:cd17432 57 SIFPLGGLFGSLLVGPLVIRLGRKGTLLLNNIFAIVAAilmglSKIAKSFEM--IIVGRFLVGINAGISLNVVPMYLGES 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 139 IPATVRGkwsarlsFVGnWSPMLSAAIGVVVIAFFS----------WRIMFLLGGIGILLAwLLSGKYFIESPRW-LAGK 207
Cdd:cd17432 135 APKNLRG-------AVG-LVPAIFITLGILLGQVLGlrellgneegWPLLLALTGVPALLQ-LLTLPFFPESPRYlLIEK 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 208 GQIAGAECQLR----------EVEQQIEREKSIRlppltsyqSNSKVKVikgtfWLLFKGEMLRRTLVAITVL-IAMNIS 276
Cdd:cd17432 206 GDEEAARKALQrlrgkedvddEMEEMLEEQRAEK--------GVGTVSV-----LELFRDRSVRWQLISIIVLmAGQQLC 272
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1785684408 277 -LYTITVWIPTIFVNSGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRRL 327
Cdd:cd17432 273 gINAIYFYADSIFLEAGIPEDKIQYVTVGTGACEVLATITCVLVIERLGRRP 324
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
62-434 |
3.74e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 42.61 E-value: 3.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 62 FTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPA 141
Cdd:cd17475 36 LLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPP 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 142 TVRG-KWSARLSFVgNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWLLSGKYFIESPRwlagkgqiagaecqlrev 220
Cdd:cd17475 116 RERGlAMGIRQTGV-PLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPA------------------ 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 221 eqqiereksirlPPLTSYQSNSKVKVIKGtfwlLFKGEMLRRTLVAITVLIAMNISLYTITVwiptIFVNSGID---VDK 297
Cdd:cd17475 177 ------------ASAATESASTLLRSLKE----VLRNRDVWLIAIAGALLVAPQFALLTFLL----LFLHDHLGlsvVAA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 298 SILMTAVIMIGAPVGIFIAALIIDHFPRRLFGSTLLIIIAVLGYIYSIQTTEWAILIYGLVMIFFLYMYVCFA----SAV 373
Cdd:cd17475 237 GALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGwnglYLT 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1785684408 374 YIPELWPTHLRLRGSGFVNAVGRIVAVFTPYGVAALLTHYGSIT-VFMVLGVMLLLCALVLS 434
Cdd:cd17475 317 LVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYApAWLALALLLVLAALLLL 378
|
|
| MFS_SVOPL |
cd17442 |
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ... |
60-188 |
4.99e-04 |
|
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341000 [Multi-domain] Cd Length: 375 Bit Score: 42.10 E-value: 4.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 60 AAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMvGYASFTEFI 139
Cdd:cd17442 39 ALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFSLLTSFAPSYIWFVFLRCMVGCGVSGHSQ-GLIIKTEFL 117
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1785684408 140 PATVRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGI-GILL 188
Cdd:cd17442 118 PTKYRGYMLPLSQIFWLAGSLLIIGLASVVIPTLGWRWLIRFASIpGIIL 167
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
60-198 |
1.72e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 40.66 E-value: 1.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 60 AAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVP--DMYWLIFFRFLMGTGMGALIMVGYASFTE 137
Cdd:COG2211 267 GLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLAD 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 138 FIPAT-------VRGKWSARLSFVGNWSPMLSAAIGVVVIAFFSWR---------------IMFLLGGIGILLAWLLSGK 195
Cdd:COG2211 347 VVDYDewktgrrREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVagaaqspsaltgirlLFFLLPAVLLLLAALLLLF 426
|
...
gi 1785684408 196 YFI 198
Cdd:COG2211 427 YPL 429
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
278-438 |
1.95e-03 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 40.25 E-value: 1.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 278 YTITVWIPTIFVNSGIDVDKSILMTAVIMIGAPVGIFIAALIIDHFPRR---LFGSTLLIIIAVLGYIYSiqtteWAILI 354
Cdd:cd17339 213 YTLMAWLPTILIDAGLSAATAGWLLSLFQLVGIPASLLVPILATRLKNQrpiVVLLAVLFIIGVLGLLFA-----PTALA 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 355 YGLVMIFFLYMYVCFASAVYIPELWPTHLRLRG--SGFVNAVGRIVAVFTPYGVAALLTHYGSITVFMVLgvmLLLCALV 432
Cdd:cd17339 288 LLWAVLLGLGGGAAFSLALTLISLRSSDPAEAAalSGMAQSVGYLLAALGPLLFGVLHDLTGSWTAPLVL---LLALTVL 364
|
....*.
gi 1785684408 433 LSIFGI 438
Cdd:cd17339 365 QLVAGL 370
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
71-141 |
2.17e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 40.14 E-value: 2.17e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1785684408 71 FIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPA 141
Cdd:COG2270 288 ALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMGGIQALSRSLLARLIPP 358
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
68-128 |
2.23e-03 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 40.45 E-value: 2.23e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1785684408 68 FGYFIGSLTGGFIGDYFGRRRAFRINLLI-----VGIAATGAAFVPDMYWLIFFRFLMGTGMGALI 128
Cdd:PRK03893 322 FGAAVGCCVGGFLGDWLGTRKAYVCSLLIsqlliIPVFAIGGANVWVLGLLLFFQQMLGQGISGLL 387
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
64-192 |
2.56e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 39.85 E-value: 2.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 64 SALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIA--ATGAAFVPDMYWLIFFRFLMGTGMGalimVGYASFTEFIPA 141
Cdd:cd17380 41 SSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLAtlLTPLLAYSSLPLLILSRILLGLGEG----VHFPSMTSLFSR 116
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1785684408 142 TVRGKWSAR-LSFV---GNWSPMLSAAIGVVVIAFFSWRIMFLL-GGIGILLAWLL 192
Cdd:cd17380 117 WVPVSERSRaVSIVtagSYLGTLLGGLIGPLLLEYYGWPSVFYFfGLLGLLWALVW 172
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
18-126 |
2.60e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 39.85 E-value: 2.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 18 RFHYRIFGIISFSLLLTGFLSYSGNVVLAKLVSNGWSNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIV 97
Cdd:cd17478 191 KGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLA 270
|
90 100
....*....|....*....|....*....
gi 1785684408 98 GIAATGAAFVPDmYWLIFFRFLMGTGMGA 126
Cdd:cd17478 271 APFLLLFLLTPG-IWSYILLVLAGFLLFA 298
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
16-193 |
3.39e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 39.48 E-value: 3.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 16 LARFHYRIFGIISFSLLLTGFLSYSGNVVLA-KLVSNGWSNNFLNAAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINL 94
Cdd:cd17473 191 AAALPWKRVLPIYFLAFLAMLLFYVIPIQLPfLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGF 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 95 LIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNWSPMLSAAI-GVVVIAFF 173
Cdd:cd17473 271 ALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVlGPLVNLTG 350
|
170 180
....*....|....*....|
gi 1785684408 174 SWRIMFLLGGIGILLAWLLS 193
Cdd:cd17473 351 GLSGAFLILGVLALVLAIVL 370
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
78-192 |
3.51e-03 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 39.42 E-value: 3.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 78 GFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATVRGKWSARLSFVGNW 157
Cdd:PRK15403 72 GPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLV 151
|
90 100 110
....*....|....*....|....*....|....*
gi 1785684408 158 SPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWLL 192
Cdd:PRK15403 152 APIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVG 186
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
60-195 |
4.22e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 39.07 E-value: 4.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 60 AAFTSALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFI 139
Cdd:COG0738 249 ALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGL 328
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1785684408 140 PATVRGKWSArLSFVGNWSPMLSAAIGVVVIAFFSWRIMFLLGGIGILLAWLLSGK 195
Cdd:COG0738 329 GKRTAAAVSA-VLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALA 383
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
64-209 |
8.44e-03 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 38.36 E-value: 8.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1785684408 64 SALMFGYFIGSLTGGFIGDYFGRRRAFRINLLIVGIAATGAAFVPDMYWLIFFRFLMGTGMGALIMVGYASFTEFIPATV 143
Cdd:cd17440 41 SIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREK 120
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1785684408 144 RGKWSARLSFVGNWSPMLSAAIGVVVI-------------AFFSWRIMFLLGGIGILLAwLLSGKYFIESPRWLAGKGQ 209
Cdd:cd17440 121 RGEHLSWLCMFWMIGGIYASAMAWAIIphygwsfsmgsayQFHSWRVFVIVCALPCVSS-VVALTFMPESPRFLLEVGK 198
|
|
| |
