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Conserved domains on  [gi|1781297602|gb|KAE9353750|]
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hypothetical protein PR003_g3697 [Phytophthora rubi]

Protein Classification

WW domain-containing protein( domain architecture ID 11094247)

WW domain-containing protein; the WW domain mediates protein-protein interaction via proline-rich motifs, such as PPxY

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 208-235 2.83e-09

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


:

Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 52.51  E-value: 2.83e-09
                          10        20
                  ....*....|....*....|....*...
gi 1781297602 208 DEWQEAYTAKGRVYYYNRRTRESSWKKP 235
Cdd:pfam00397   3 PGWEERWDPDGRVYYYNHETGETQWEKP 30
zf-C2HC_2 pfam13913
zinc-finger of a C2HC-type; This family contains a number of divergent C2H2 type zinc fingers.
 451-474 6.63e-08

zinc-finger of a C2HC-type; This family contains a number of divergent C2H2 type zinc fingers.


:

Pssm-ID: 464037  Cd Length: 25  Bit Score: 48.34  E-value: 6.63e-08
                          10        20
                  ....*....|....*....|....
gi 1781297602 451 QMETCRYCNRSFAEGRLAKHEAVC 474
Cdd:pfam13913   1 ELVPCPICGRTFNPDRLAKHEKIC 24
PRP40 super family cl34905
Splicing factor [RNA processing and modification];
208-287 1.28e-06

Splicing factor [RNA processing and modification];


The actual alignment was detected with superfamily member COG5104:

Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 51.23  E-value: 1.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781297602 208 DEWQEAYTAKGRVYYYNRRTRESSWKKPSHYNpsenqpqpaaaATEESELHRSVLRQSLGYNpsasvaGSVPAVSTMERQ 287
Cdd:COG5104    56 DPWKECRTADGKVYYYNSITRESRWKIPPERK-----------KVEPIAEQKHDERSMIGGN------GNDMAITDHETS 118
zf-C2HC_2 pfam13913
zinc-finger of a C2HC-type; This family contains a number of divergent C2H2 type zinc fingers.
 535-559 8.66e-06

zinc-finger of a C2HC-type; This family contains a number of divergent C2H2 type zinc fingers.


:

Pssm-ID: 464037  Cd Length: 25  Bit Score: 42.57  E-value: 8.66e-06
                          10        20
                  ....*....|....*....|....*
gi 1781297602 535 TLVLCPCCRRKFAPSGAQQHIAICK 559
Cdd:pfam13913   1 ELVPCPICGRTFNPDRLAKHEKICK 25
 
Name Accession Description Interval E-value
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 208-235 2.83e-09

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 52.51  E-value: 2.83e-09
                          10        20
                  ....*....|....*....|....*...
gi 1781297602 208 DEWQEAYTAKGRVYYYNRRTRESSWKKP 235
Cdd:pfam00397   3 PGWEERWDPDGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 208-235 6.22e-08

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 48.68  E-value: 6.22e-08
                          10        20
                  ....*....|....*....|....*...
gi 1781297602 208 DEWQEAYTAKGRVYYYNRRTRESSWKKP 235
Cdd:cd00201     2 PGWEERWDPDGRVYYYNHNTKETQWEDP 29
zf-C2HC_2 pfam13913
zinc-finger of a C2HC-type; This family contains a number of divergent C2H2 type zinc fingers.
 451-474 6.63e-08

zinc-finger of a C2HC-type; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464037  Cd Length: 25  Bit Score: 48.34  E-value: 6.63e-08
                          10        20
                  ....*....|....*....|....
gi 1781297602 451 QMETCRYCNRSFAEGRLAKHEAVC 474
Cdd:pfam13913   1 ELVPCPICGRTFNPDRLAKHEKIC 24
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 210-235 1.04e-06

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 45.28  E-value: 1.04e-06
                           10        20
                   ....*....|....*....|....*.
gi 1781297602  210 WQEAYTAKGRVYYYNRRTRESSWKKP 235
Cdd:smart00456   6 WEERKDPDGRPYYYNHETKETQWEKP 31
PRP40 COG5104
Splicing factor [RNA processing and modification];
208-287 1.28e-06

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 51.23  E-value: 1.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781297602 208 DEWQEAYTAKGRVYYYNRRTRESSWKKPSHYNpsenqpqpaaaATEESELHRSVLRQSLGYNpsasvaGSVPAVSTMERQ 287
Cdd:COG5104    56 DPWKECRTADGKVYYYNSITRESRWKIPPERK-----------KVEPIAEQKHDERSMIGGN------GNDMAITDHETS 118
PRP40 COG5104
Splicing factor [RNA processing and modification];
209-235 2.19e-06

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 50.46  E-value: 2.19e-06
                          10        20
                  ....*....|....*....|....*..
gi 1781297602 209 EWQEAYTAKGRVYYYNRRTRESSWKKP 235
Cdd:COG5104    16 EWEELKAPDGRIYYYNKRTGKSSWEKP 42
zf-C2HC_2 pfam13913
zinc-finger of a C2HC-type; This family contains a number of divergent C2H2 type zinc fingers.
 535-559 8.66e-06

zinc-finger of a C2HC-type; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464037  Cd Length: 25  Bit Score: 42.57  E-value: 8.66e-06
                          10        20
                  ....*....|....*....|....*
gi 1781297602 535 TLVLCPCCRRKFAPSGAQQHIAICK 559
Cdd:pfam13913   1 ELVPCPICGRTFNPDRLAKHEKICK 25
 
Name Accession Description Interval E-value
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 208-235 2.83e-09

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 52.51  E-value: 2.83e-09
                          10        20
                  ....*....|....*....|....*...
gi 1781297602 208 DEWQEAYTAKGRVYYYNRRTRESSWKKP 235
Cdd:pfam00397   3 PGWEERWDPDGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 208-235 6.22e-08

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 48.68  E-value: 6.22e-08
                          10        20
                  ....*....|....*....|....*...
gi 1781297602 208 DEWQEAYTAKGRVYYYNRRTRESSWKKP 235
Cdd:cd00201     2 PGWEERWDPDGRVYYYNHNTKETQWEDP 29
zf-C2HC_2 pfam13913
zinc-finger of a C2HC-type; This family contains a number of divergent C2H2 type zinc fingers.
 451-474 6.63e-08

zinc-finger of a C2HC-type; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464037  Cd Length: 25  Bit Score: 48.34  E-value: 6.63e-08
                          10        20
                  ....*....|....*....|....
gi 1781297602 451 QMETCRYCNRSFAEGRLAKHEAVC 474
Cdd:pfam13913   1 ELVPCPICGRTFNPDRLAKHEKIC 24
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 210-235 1.04e-06

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 45.28  E-value: 1.04e-06
                           10        20
                   ....*....|....*....|....*.
gi 1781297602  210 WQEAYTAKGRVYYYNRRTRESSWKKP 235
Cdd:smart00456   6 WEERKDPDGRPYYYNHETKETQWEKP 31
PRP40 COG5104
Splicing factor [RNA processing and modification];
208-287 1.28e-06

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 51.23  E-value: 1.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1781297602 208 DEWQEAYTAKGRVYYYNRRTRESSWKKPSHYNpsenqpqpaaaATEESELHRSVLRQSLGYNpsasvaGSVPAVSTMERQ 287
Cdd:COG5104    56 DPWKECRTADGKVYYYNSITRESRWKIPPERK-----------KVEPIAEQKHDERSMIGGN------GNDMAITDHETS 118
PRP40 COG5104
Splicing factor [RNA processing and modification];
209-235 2.19e-06

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 50.46  E-value: 2.19e-06
                          10        20
                  ....*....|....*....|....*..
gi 1781297602 209 EWQEAYTAKGRVYYYNRRTRESSWKKP 235
Cdd:COG5104    16 EWEELKAPDGRIYYYNKRTGKSSWEKP 42
zf-C2HC_2 pfam13913
zinc-finger of a C2HC-type; This family contains a number of divergent C2H2 type zinc fingers.
 535-559 8.66e-06

zinc-finger of a C2HC-type; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464037  Cd Length: 25  Bit Score: 42.57  E-value: 8.66e-06
                          10        20
                  ....*....|....*....|....*
gi 1781297602 535 TLVLCPCCRRKFAPSGAQQHIAICK 559
Cdd:pfam13913   1 ELVPCPICGRTFNPDRLAKHEKICK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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