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Conserved domains on  [gi|616690901|gb|KAE88457|]
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hypothetical protein W632_00342 [Staphylococcus aureus VET0402R]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
27-198 2.78e-29

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 109.71  E-value: 2.78e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  27 IEEDPTIIENYINAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIKLYQQALQTEIEQVDCNY 106
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901 107 MIGMAFNQLESFKLALPYLMTAAELDKDkDTEVQFQYGLVLCQLEMFNEAITQLKHVLTIDKNHVDARYNLGLALfMKNE 186
Cdd:COG0457   81 NLGLALQALGRYEEALEDYDKALELDPD-DAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIAL-EKLG 158

                        170
                 ....*....|..
gi 616690901 187 DIDEAITHFKEA 198
Cdd:COG0457  159 RYEEALELLEKL 170
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
27-198 2.78e-29

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 109.71  E-value: 2.78e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  27 IEEDPTIIENYINAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIKLYQQALQTEIEQVDCNY 106
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901 107 MIGMAFNQLESFKLALPYLMTAAELDKDkDTEVQFQYGLVLCQLEMFNEAITQLKHVLTIDKNHVDARYNLGLALfMKNE 186
Cdd:COG0457   81 NLGLALQALGRYEEALEDYDKALELDPD-DAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIAL-EKLG 158

                        170
                 ....*....|..
gi 616690901 187 DIDEAITHFKEA 198
Cdd:COG0457  159 RYEEALELLEKL 170
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 14-219 3.83e-15

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 73.48  E-value: 3.83e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   14 GKIEEALQALFGNIEEDPTIIENYINAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIKLYQQ 93
Cdd:TIGR00990 345 GKHLEALADLSKSIELDPRVTQSYIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIYYHRAQLHFIKGEFAQAGKDYQK 424

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   94 ALQTEIEQVDCNYMIGMAFNQLESFKLALPyLMTAAELDKDKDTEVQFQYGLVLCQLEMFNEAITQLKHVLTIDKN---- 169
Cdd:TIGR00990 425 SIDLDPDFIFSHIQLGVTQYKEGSIASSMA-TFRRCKKNFPEAPDVYNYYGELLLDQNKFDEAIEKFDTAIELEKEtkpm 503

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 616690901  170 --HVDARYNLGLALFMKNEDIDEAITHFKEAVTIDPKhllSQHALKTFTKMK 219
Cdd:TIGR00990 504 ymNVLPLINKALALFQWKQDFIEAENLCEKALIIDPE---CDIAVATMAQLL 552
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 9-198 3.04e-09

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 55.71  E-value: 3.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   9 QYIQNG------KIEEALQALFGNIEEDPTIIENYINA--GIV------LADANEIE-KAERFFQKALTIDPKNGVVFYN 73
Cdd:cd24142   86 QYYEKGieileeELQALQAASAEAEEEAEELKRKLSSAlcALAeiymtdLCDEPDAEqRCEELITKALELDPTNPEALQT 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  74 LANVYYNQQRYQEAIKLYQQALQTEIEQVDcnymigmafnqlesfKLALPYLMTAAELDKDKDTEVQFQYGLVLCQLEMF 153
Cdd:cd24142  166 LASLRISQQRPDEAKEALRRSLELWKDLKE---------------EDEEEAEEDEAEEEDVPSYEFRISLAKLLIELEMY 230

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 616690901 154 NEAITQLKHVLTIDKNHVDARYNLGLALFMKNEDIDEAITHFKEA 198
Cdd:cd24142  231 EEALEVLEQLLDEDDEDVEVWYLLGWAYYLLGEKEQEEAAELLRD 275
TPR_12 pfam13424
Tetratricopeptide repeat;
33-96 1.59e-06

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 44.69  E-value: 1.59e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 616690901   33 IIENYINAGIVLADANEIEKAERFFQKALTI--------DPKNGVVFYNLANVYYNQQRYQEAIKLYQQALQ 96
Cdd:pfam13424   2 VATALNNLAAVLRRLGRYDEALELLEKALEIarrllgpdHPLTATTLLNLGRLYLELGRYEEALELLERALA 73
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 70-96 1.13e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 38.20  E-value: 1.13e-04
                           10        20
                   ....*....|....*....|....*..
gi 616690901    70 VFYNLANVYYNQQRYQEAIKLYQQALQ 96
Cdd:smart00028   3 ALYNLGNAYLKLGDYDEALEYYEKALE 29
PRK11788 PRK11788
tetratricopeptide repeat protein; Provisional
 47-100 1.63e-04

tetratricopeptide repeat protein; Provisional


Pssm-ID: 236983 [Multi-domain]  Cd Length: 389  Bit Score: 41.72  E-value: 1.63e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 616690901  47 ANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIKLYQQALQTEIE 100
Cdd:PRK11788 193 RGDLDAARALLKKALAADPQCVRASILLGDLALAQGDYAAAIEALERVEEQDPE 246
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
27-198 2.78e-29

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 109.71  E-value: 2.78e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  27 IEEDPTIIENYINAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIKLYQQALQTEIEQVDCNY 106
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901 107 MIGMAFNQLESFKLALPYLMTAAELDKDkDTEVQFQYGLVLCQLEMFNEAITQLKHVLTIDKNHVDARYNLGLALfMKNE 186
Cdd:COG0457   81 NLGLALQALGRYEEALEDYDKALELDPD-DAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIAL-EKLG 158

                        170
                 ....*....|..
gi 616690901 187 DIDEAITHFKEA 198
Cdd:COG0457  159 RYEEALELLEKL 170
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 9-206 1.61e-26

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 102.89  E-value: 1.61e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   9 QYIQNGKIEEALQALFGNIEEDPTIIENYINAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAI 88
Cdd:COG2956   17 NYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAE 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  89 KLYQQALQTEIEQVDCNYMIGMAFNQLESFKLALPYLMTAAELDkDKDTEVQFQYGLVLCQLEMFNEAITQLKHVLTIDK 168
Cdd:COG2956   97 ELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLG-PENAHAYCELAELYLEQGDYDEAIEALEKALKLDP 175

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 616690901 169 NHVDARYNLGLaLFMKNEDIDEAITHFKEAVTIDPKHL 206
Cdd:COG2956  176 DCARALLLLAE-LYLEQGDYEEAIAALERALEQDPDYL 212
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 4-191 3.16e-24

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 100.07  E-value: 3.16e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   4 QQTIYQYIQNGKIEEALQALFGNIEEDPTIIENYINAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQR 83
Cdd:COG3914   48 LAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGR 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  84 YQEAIKLYQQALQTEIEQVDCNYMIGMAFNQLESFKLALPYLMTAAELDKDkDTEVQFQYGLVLCQLEMFNEAITQLKHV 163
Cdd:COG3914  128 LEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPD-NAEALNNLGNALQDLGRLEEAIAAYRRA 206

                        170       180
                 ....*....|....*....|....*...
gi 616690901 164 LTIDKNHVDARYNLgLALFMKNEDIDEA 191
Cdd:COG3914  207 LELDPDNADAHSNL-LFALRQACDWEVY 233
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 37-212 1.31e-20

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 87.09  E-value: 1.31e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  37 YINAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIKLYQQALQTEIEQVDCNYMIGMAFNQLE 116
Cdd:COG2956   11 WYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901 117 SFKLALPYLMTAAELDkDKDTEVQFQYGLVLCQLEMFNEAITQLKHVLTIDKNHVDARYNLGLALFMKNeDIDEAITHFK 196
Cdd:COG2956   91 LLDRAEELLEKLLELD-PDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQG-DYDEAIEALE 168

                        170
                 ....*....|....*.
gi 616690901 197 EAVTIDPKHLLSQHAL 212
Cdd:COG2956  169 KALKLDPDCARALLLL 184
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
10-162 2.37e-18

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 80.44  E-value: 2.37e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  10 YIQNGKIEEALQALFGNIEEDPTIIENYINAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIK 89
Cdd:COG0457   52 YLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIE 131

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 616690901  90 LYQQALQTEIEQVDCNYMIGMAFNQLESFKLALPYLMTAAELDKDKDTEVQFQYGLVLCQLEMFNEAITQLKH 162
Cdd:COG0457  132 AYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALE 204
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 37-205 8.34e-18

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 76.77  E-value: 8.34e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  37 YINAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIKLYQQALqteieqvdcnymigmafnqle 116
Cdd:COG4783    7 LYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEAL--------------------- 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901 117 sfklalpylmtaaELDKDkDTEVQFQYGLVLCQLEMFNEAITQLKHVLTIDKNHVDARYNLGLALfMKNEDIDEAITHFK 196
Cdd:COG4783   66 -------------ELDPD-EPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAY-RALGRPDEAIAALE 130


                 ....*....
gi 616690901 197 EAVTIDPKH 205
Cdd:COG4783  131 KALELDPDD 139
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 9-134 2.08e-17

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 75.61  E-value: 2.08e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   9 QYIQNGKIEEALQALFGNIEEDPTIIENYINAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAI 88
Cdd:COG4783   13 ALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEAL 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 616690901  89 KLYQQALQTEIEQVDCNYMIGMAFNQLESFKLALPYLMTAAELDKD 134
Cdd:COG4783   93 ALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPD 138
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 52-204 1.18e-16

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 73.12  E-value: 1.18e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  52 KAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIKLYQQALQteieqvdcnymigmafnqlesfklalpylmtaaeL 131
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALR----------------------------------L 46

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 616690901 132 DKDkDTEVQFQYGLVLCQLEMFNEAITQLKHVLTIDKNHVDARYNLGLALFMkNEDIDEAITHFKEAVTIDPK 204
Cdd:COG4235   47 DPD-NADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQ-QGDYAEAIAAWQKLLALLPA 117
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 18-142 4.50e-16

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 71.58  E-value: 4.50e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  18 EALQALFGNIEEDPTIIENYINAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIKLYQQALQT 97
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 616690901  98 EIEQVDCNYMIGMAFNQLESFKLALPYLMTAAELDKDKDTEVQFQ 142
Cdd:COG4235   81 DPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPARLLE 125
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 14-219 3.83e-15

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 73.48  E-value: 3.83e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   14 GKIEEALQALFGNIEEDPTIIENYINAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIKLYQQ 93
Cdd:TIGR00990 345 GKHLEALADLSKSIELDPRVTQSYIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIYYHRAQLHFIKGEFAQAGKDYQK 424

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   94 ALQTEIEQVDCNYMIGMAFNQLESFKLALPyLMTAAELDKDKDTEVQFQYGLVLCQLEMFNEAITQLKHVLTIDKN---- 169
Cdd:TIGR00990 425 SIDLDPDFIFSHIQLGVTQYKEGSIASSMA-TFRRCKKNFPEAPDVYNYYGELLLDQNKFDEAIEKFDTAIELEKEtkpm 503

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 616690901  170 --HVDARYNLGLALFMKNEDIDEAITHFKEAVTIDPKhllSQHALKTFTKMK 219
Cdd:TIGR00990 504 ymNVLPLINKALALFQWKQDFIEAENLCEKALIIDPE---CDIAVATMAQLL 552
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 10-167 1.30e-14

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 70.91  E-value: 1.30e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  10 YIQNGKIEEALQALFGNIEEDPTIIENYINAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIK 89
Cdd:COG2956  120 YEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIA 199

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 616690901  90 LYQQALQTEIEQVDCNYMIGMAFNQLESFKLALPYLMTAAELDKDKDteVQFQYGLVLCQLEMFNEAITQLKHVLTID 167
Cdd:COG2956  200 ALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDD--LLLALADLLERKEGLEAALALLERQLRRH 275
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 10-97 3.80e-14

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 66.57  E-value: 3.80e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  10 YIQNGKIEEALQALFGNIEEDPTIIENYINAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIK 89
Cdd:COG4235   27 YLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIA 106


                 ....*...
gi 616690901  90 LYQQALQT 97
Cdd:COG4235  107 AWQKLLAL 114
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1-98 1.80e-13

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 65.75  E-value: 1.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   1 MIDQQTIYQYIQNGKIEEALQALFGNIEEDPTIIENYINAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYN 80
Cdd:COG5010   55 AIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLS 134

                         90
                 ....*....|....*...
gi 616690901  81 QQRYQEAIKLYQQALQTE 98
Cdd:COG5010  135 LGQDDEAKAALQRALGTS 152
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 10-206 2.94e-13

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 68.19  E-value: 2.94e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   10 YIQNGKIEEALqALFGNIEEDPTiiENYINAGIVLADA----NEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQ 85
Cdd:TIGR02917 100 YLLQGKFQQVL-DELPGKTLLDD--EGAAELLALRGLAylglGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFD 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   86 EAIKLYQQALQTEIEQVDCNYMIGMAFNQLESFKLALPYLMTAAELDKDkDTEVQFQYGLVLCQLEMFNEAITQLKHVLT 165
Cdd:TIGR02917 177 EARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPN-NIAVLLALATILIEAGEFEEAEKHADALLK 255

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 616690901  166 IDKNHVDARYNLGLALFMKNeDIDEAITHFKEAVTIDPKHL 206
Cdd:TIGR02917 256 KAPNSPLAHYLKALVDFQKK-NYEDARETLQDALKSAPEYL 295
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 8-96 7.42e-13

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 63.29  E-value: 7.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   8 YQYIQNGKIEEALQALFGNIEEDPTIIENYINAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEA 87
Cdd:COG4783   46 EILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEA 125


                 ....*....
gi 616690901  88 IKLYQQALQ 96
Cdd:COG4783  126 IAALEKALE 134
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
10-96 8.14e-13

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 62.11  E-value: 8.14e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  10 YIQNGKIEEALQALFGNIEEDPTIIENYINAGIVLADANEIEKAERfFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIK 89
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEALA 80


                 ....*..
gi 616690901  90 LYQQALQ 96
Cdd:COG3063   81 YLERALE 87
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 7-200 8.45e-13

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 67.03  E-value: 8.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901    7 IYQYIQNGKIEEAL-QALFGNI---EEDPTIIENYINAGIVLADANEI--------------EKAERFFQKALTIDPKNG 68
Cdd:TIGR02917 691 IAKSLQKQHPKAALgFELEGDLylrQKDYPAAIQAYRKALKRAPSSQNaiklhrallasgntAEAVKTLEAWLKTHPNDA 770

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   69 VVFYNLANVYYNQQRYQEAIKLYQQALQTEIEQVDCNYMIGMAFNQLESFKlALPYLMTAAELdKDKDTEVQFQYGLVLC 148
Cdd:TIGR02917 771 VLRTALAELYLAQKDYDKAIKHYQTVVKKAPDNAVVLNNLAWLYLELKDPR-ALEYAERALKL-APNIPAILDTLGWLLV 848

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 616690901  149 QLEMFNEAITQLKHVLTIDKNHVDARYNLGLALFmKNEDIDEAITHFKEAVT 200
Cdd:TIGR02917 849 EKGEADRALPLLRKAVNIAPEAAAIRYHLALALL-ATGRKAEARKELDKLLN 899
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
43-134 1.47e-12

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 61.34  E-value: 1.47e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  43 VLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIKlYQQALQTEIEQVDCNYMIGMAFNQLESFKLAL 122
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEAL 79

                         90
                 ....*....|..
gi 616690901 123 PYLMTAAELDKD 134
Cdd:COG3063   80 AYLERALELDPS 91
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 10-207 3.61e-12

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 65.10  E-value: 3.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   10 YIQNGKIEEALQALFGNIEEDPTIIENYINAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIK 89
Cdd:TIGR02917 611 QLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTESAKK 690

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   90 LYQQALQTEIEQVDCNYMIGMAFNQLESFKLALPYLMTAAELDKDKDTEVQFqyGLVLCQLEMFNEAITQLKHVLTIDKN 169
Cdd:TIGR02917 691 IAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSSQNAIKL--HRALLASGNTAEAVKTLEAWLKTHPN 768

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 616690901  170 HVDARYNLGlALFMKNEDIDEAITHFKEAVTIDPKHLL 207
Cdd:TIGR02917 769 DAVLRTALA-ELYLAQKDYDKAIKHYQTVVKKAPDNAV 805
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 17-133 4.51e-11

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 59.20  E-value: 4.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  17 EEALQALFGNIEEDPTIIENYINAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIKLYQQALQ 96
Cdd:COG5010   37 TKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALA 116

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 616690901  97 TEIEQVDCNYMIGMAFNQLESFKLALPYLMTAAELDK 133
Cdd:COG5010  117 LSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
10-96 5.19e-11

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 59.93  E-value: 5.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  10 YIQNGKIEEALQALFGNIEEDPTIIENYINAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIK 89
Cdd:COG4785   83 YDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIA 162


                 ....*..
gi 616690901  90 LYQQALQ 96
Cdd:COG4785  163 DLEKALE 169
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 10-206 7.95e-11

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 60.87  E-value: 7.95e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   10 YIQNGKIEEA---LQALFGNIEEDPTIIENyinAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQE 86
Cdd:TIGR02917 339 QLRLGRVDEAiatLSPALGLDPDDPAALSL---LGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGISKLSQGDPSE 415

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   87 AIKLYQQALQTEIEQVDCNYMIGMAFNQLESFKLALPylmTAAELDKDKDTEVQFQyglVLCQLEMFNE-----AITQLK 161
Cdd:TIGR02917 416 AIADLETAAQLDPELGRADLLLILSYLRSGQFDKALA---AAKKLEKKQPDNASLH---NLLGAIYLGKgdlakAREAFE 489

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 616690901  162 HVLTIDKNHVDARYNLgLALFMKNEDIDEAITHFKEAVTIDPKHL 206
Cdd:TIGR02917 490 KALSIEPDFFPAAANL-ARIDIQEGNPDDAIQRFEKVLTIDPKNL 533
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
19-199 1.34e-10

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 58.77  E-value: 1.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  19 ALQALFGNIEEDPTIIENYINAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIKLYQQALQTE 98
Cdd:COG4785   58 LAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELD 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  99 IEQVDCNYMIGMAFNQLESFKLALPYLMTAAELDKDKDTEVQFQYglvLCQLEMFNEAitqlkhvltidknhvdARYNLG 178
Cdd:COG4785  138 PDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPERALWLY---LAERKLDPEK----------------ALALLL 198

                        170       180
                 ....*....|....*....|....
gi 616690901 179 LALFMKNE---DIDEAITHFKEAV 199
Cdd:COG4785  199 EDWATAYLlqgDTEEARELFKLAL 222
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
71-206 2.26e-10

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 58.35  E-value: 2.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  71 FYNLANVYYNQQRYQEAIKLYQQALqTEIEQVDCNYMIGMAFNQLES--FKLALPYLMTAAELDKD-KDTEVQFQYGLVL 147
Cdd:COG4700   92 RVRLADALLELGRYDEAIELYEEAL-TGIFADDPHILLGLAQALFELgrYAEALETLEKLIAKNPDfKSSDAHLLYARAL 170

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 616690901 148 CQLEMFNEAITQLKhVLTIDKNHVDARYNLGLALfMKNEDIDEAITHFKEAVTiDPKHL 206
Cdd:COG4700  171 EALGDLEAAEAELE-ALARRYSGPEARYRYAKFL-ARQGRTAEAKELLEEILD-EAKHM 226
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 12-98 2.49e-10

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 58.12  E-value: 2.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   12 QNGKIEEAlQALFGNIEEDPTIIENYI---NAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAI 88
Cdd:TIGR02521 111 QQGKYEQA-MQQFEQAIEDPLYPQPARsleNAGLCALKAGDFDKAEKYLTRALQIDPQRPESLLELAELYYLRGQYKDAR 189

                          90
                  ....*....|
gi 616690901   89 KLYQQALQTE 98
Cdd:TIGR02521 190 AYLERYQQTY 199
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 14-204 9.59e-10

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 57.79  E-value: 9.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   14 GKIEEALQALFGNIEEDPTIIENYINAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIKLYQQ 93
Cdd:TIGR02917 207 GNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKKAPNSPLAHYLKALVDFQKKNYEDARETLQD 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   94 ALQTEIEQVDCNYMIGMAFNQLESFKLALPYLMTAAELDKDKDTEVQFqygLVLCQLEM--FNEAITQLKHVLTIDKNHV 171
Cdd:TIGR02917 287 ALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAPNSHQARRL---LASIQLRLgrVDEAIATLSPALGLDPDDP 363

                         170       180       190
                  ....*....|....*....|....*....|...
gi 616690901  172 DARYNLGLALfMKNEDIDEAITHFKEAVTIDPK 204
Cdd:TIGR02917 364 AALSLLGEAY-LALGDFEKAAEYLAKATELDPE 395
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 73-212 2.23e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 56.54  E-value: 2.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  73 NLANVYYNQQRYQEAIKLYQQALQTEIEQVDCNYMIGMAFNQLESFKLALPYLM--------TAAELDKDKDTEVQFQYG 144
Cdd:COG3914    6 LLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALlalaageaAAAAAALLLLAALLELAA 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 616690901 145 LVLCQLEMFNEAITQLKHVLTIDKNHVDARYNLGLALFmKNEDIDEAITHFKEAVTIDPKHLLSQHAL 212
Cdd:COG3914   86 LLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLL-ALGRLEEALAALRRALALNPDFAEAYLNL 152
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 9-198 3.04e-09

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 55.71  E-value: 3.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   9 QYIQNG------KIEEALQALFGNIEEDPTIIENYINA--GIV------LADANEIE-KAERFFQKALTIDPKNGVVFYN 73
Cdd:cd24142   86 QYYEKGieileeELQALQAASAEAEEEAEELKRKLSSAlcALAeiymtdLCDEPDAEqRCEELITKALELDPTNPEALQT 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  74 LANVYYNQQRYQEAIKLYQQALQTEIEQVDcnymigmafnqlesfKLALPYLMTAAELDKDKDTEVQFQYGLVLCQLEMF 153
Cdd:cd24142  166 LASLRISQQRPDEAKEALRRSLELWKDLKE---------------EDEEEAEEDEAEEEDVPSYEFRISLAKLLIELEMY 230

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 616690901 154 NEAITQLKHVLTIDKNHVDARYNLGLALFMKNEDIDEAITHFKEA 198
Cdd:cd24142  231 EEALEVLEQLLDEDDEDVEVWYLLGWAYYLLGEKEQEEAAELLRD 275
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 10-93 5.17e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 55.38  E-value: 5.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  10 YIQNGKIEEALQALFGNIEEDPTIIENYINAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIK 89
Cdd:COG3914  156 LRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDR 235


                 ....
gi 616690901  90 LYQQ 93
Cdd:COG3914  236 FEEL 239
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 7-209 1.14e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 54.70  E-value: 1.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901    7 IYQYIQNGKIEEALQALFGNIEEDPTIIENYINAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQE 86
Cdd:TIGR02917 438 ILSYLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDD 517

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   87 AIKLYQQALQTEIEQVDcnymigmAFNQLESFKL-------ALPYLMTAAELDKdkdTEVQFQYGLVLCQLEMFN--EAI 157
Cdd:TIGR02917 518 AIQRFEKVLTIDPKNLR-------AILALAGLYLrtgneeeAVAWLEKAAELNP---QEIEPALALAQYYLGKGQlkKAL 587

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 616690901  158 TQLKHVLTIDKNHVDARYNLGLALFMkNEDIDEAITHFKEAVTIDPKHLLSQ 209
Cdd:TIGR02917 588 AILNEAADAAPDSPEAWLMLGRAQLA-AGDLNKAVSSFKKLLALQPDSALAL 638
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 52-203 2.26e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 51.50  E-value: 2.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  52 KAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIKLYQQALQTEIEQVDCNYMIGMAFNQLESFKLALPYLMTAAEL 131
Cdd:COG5010    4 LEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQL 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 616690901 132 DKDkDTEVQFQYGLVLCQLEMFNEAITQLKHVLTIDKNHVDARYNLGLALfMKNEDIDEAITHFKEAVTIDP 203
Cdd:COG5010   84 DPN-NPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALL-LSLGQDDEAKAALQRALGTSP 153
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
111-206 3.19e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 49.78  E-value: 3.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901 111 AFNQLESFKLALPYLMTAAELDKDkDTEVQFQYGLVLCQLEMFNEAItQLKHVLTIDKNHVDARYNLGLALfMKNEDIDE 190
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPD-NADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELL-LELGDYDE 77

                         90
                 ....*....|....*.
gi 616690901 191 AITHFKEAVTIDPKHL 206
Cdd:COG3063   78 ALAYLERALELDPSAL 93
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 135-206 1.50e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 48.85  E-value: 1.50e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 616690901 135 KDTEVQFQYGLVLCQLEMFNEAITQLKHVLTIDKNHVDARYNLGLALFMKNeDIDEAITHFKEAVTIDPKHL 206
Cdd:COG4235   15 NDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAG-DTEEAEELLERALALDPDNP 85
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 19-205 1.99e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 50.85  E-value: 1.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   19 ALQALFGNIEEDPtiiENYINAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIKLYQQALQTE 98
Cdd:TIGR02917  10 IALALSACGDQSP---EELIEAAKSYLQKNKYKAAIIQLKNALQKDPNDAEARFLLGKIYLALGDYAAAEKELRKALSLG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   99 IEQVDCNYMIGMAFNQLESFKLALPYLMTAAELDKDKDTEVQFQYGLVLCQLEMFNEAITQLKHVLTIDKNHVDARynLG 178
Cdd:TIGR02917  87 YPKNQVLPLLARAYLLQGKFQQVLDELPGKTLLDDEGAAELLALRGLAYLGLGQLELAQKSYEQALAIDPRSLYAK--LG 164

                         170       180
                  ....*....|....*....|....*...
gi 616690901  179 LA-LFMKNEDIDEAITHFKEAVTIDPKH 205
Cdd:TIGR02917 165 LAqLALAENRFDEARALIDEVLTADPGN 192
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
130-212 2.16e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.01  E-value: 2.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901 130 ELDKDkDTEVQFQYGLVLCQLEMFNEAITQLKHVLTIDKNHVDARYNLGLALFMKNeDIDEAITHFKEAVTIDPKHLLSQ 209
Cdd:COG0457    2 ELDPD-DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLG-RYEEALADYEQALELDPDDAEAL 79


                 ...
gi 616690901 210 HAL 212
Cdd:COG0457   80 NNL 82
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 19-168 2.54e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 48.80  E-value: 2.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  19 ALQALFGNIEEDPTIIENYINAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIKLYQQALQTE 98
Cdd:COG5010    5 EGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLD 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  99 IEQVDCNYMIGMAFNQLESFKLALPYLMTAAELDKDkDTEVQFQYGLVLCQLEMFNEAITQLKHVLTIDK 168
Cdd:COG5010   85 PNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPD-NPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 134-212 1.25e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 46.34  E-value: 1.25e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 616690901 134 DKDTEVQFQYGLVLCQLEMFNEAITQLKHVLTIDKNHVDARYNLGLALFMKNeDIDEAITHFKEAVTIDPKHLLSQHAL 212
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLG-DLDEAIVLLHEALELDPDEPEARLNL 78
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 111-212 1.36e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 46.49  E-value: 1.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901 111 AFNQLESFKLALPYLMTAAELDKDKDTEVQFQYGLVLCQLEMFNEAITQLKHVLTIDKNHVDARYNLGLALfMKNEDIDE 190
Cdd:COG5010   28 EAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLY-SRSGDKDE 106

                         90       100
                 ....*....|....*....|..
gi 616690901 191 AITHFKEAVTIDPKHLLSQHAL 212
Cdd:COG5010  107 AKEYYEKALALSPDNPNAYSNL 128
TPR_12 pfam13424
Tetratricopeptide repeat;
33-96 1.59e-06

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 44.69  E-value: 1.59e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 616690901   33 IIENYINAGIVLADANEIEKAERFFQKALTI--------DPKNGVVFYNLANVYYNQQRYQEAIKLYQQALQ 96
Cdd:pfam13424   2 VATALNNLAAVLRRLGRYDEALELLEKALEIarrllgpdHPLTATTLLNLGRLYLELGRYEEALELLERALA 73
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
129-205 3.77e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 46.06  E-value: 3.77e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 616690901 129 AELDKDKDTEVQFQYGLVLCQLEMFNEAITQLKHVLTIDKNHVDARYNLGLALFmKNEDIDEAITHFKEAVTIDPKH 205
Cdd:COG4785   65 RALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYL-LLGDYDAALEDFDRALELDPDY 140
TPR_1 pfam00515
Tetratricopeptide repeat;
70-96 2.66e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 40.10  E-value: 2.66e-05
                          10        20
                  ....*....|....*....|....*..
gi 616690901   70 VFYNLANVYYNQQRYQEAIKLYQQALQ 96
Cdd:pfam00515   3 ALYNLGNAYFKLGKYDEALEYYEKALE 29
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 70-96 6.04e-05

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 39.04  E-value: 6.04e-05
                          10        20
                  ....*....|....*....|....*..
gi 616690901   70 VFYNLANVYYNQQRYQEAIKLYQQALQ 96
Cdd:pfam07719   3 ALYNLGLAYYKLGDYEEALEAYEKALE 29
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 8-97 7.34e-05

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 40.75  E-value: 7.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   8 YQYIQNGKIEEALQALFGNIEEDPT---IIENYINAGIVLADANEIEKAERFFQKALTIDPKNGVV---FYNLANVYYNQ 81
Cdd:COG1729    1 KALLKAGDYDEAIAAFKAFLKRYPNsplAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKApdaLLKLGLSYLEL 80

                         90
                 ....*....|....*.
gi 616690901  82 QRYQEAIKLYQQALQT 97
Cdd:COG1729   81 GDYDKARATLEELIKK 96
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 44-130 8.77e-05

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 40.75  E-value: 8.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  44 LADANEIEKAERFFQKALTIDPKNGV---VFYNLANVYYNQQRYQEAIKLYQQALQT---EIEQVDCNYMIGMAFNQLES 117
Cdd:COG1729    3 LLKAGDYDEAIAAFKAFLKRYPNSPLapdALYWLGEAYYALGDYDEAAEAFEKLLKRypdSPKAPDALLKLGLSYLELGD 82

                         90
                 ....*....|...
gi 616690901 118 FKLALPYLMTAAE 130
Cdd:COG1729   83 YDKARATLEELIK 95
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 70-96 1.13e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 38.20  E-value: 1.13e-04
                           10        20
                   ....*....|....*....|....*..
gi 616690901    70 VFYNLANVYYNQQRYQEAIKLYQQALQ 96
Cdd:smart00028   3 ALYNLGNAYLKLGDYDEALEYYEKALE 29
TPR_10 pfam13374
Tetratricopeptide repeat;
73-97 1.19e-04

Tetratricopeptide repeat;


Pssm-ID: 463861 [Multi-domain]  Cd Length: 42  Bit Score: 38.25  E-value: 1.19e-04
                          10        20
                  ....*....|....*....|....*
gi 616690901   73 NLANVYYNQQRYQEAIKLYQQALQT 97
Cdd:pfam13374   7 NLANALRAQGRYDEAEELLEEALAI 31
PRK11788 PRK11788
tetratricopeptide repeat protein; Provisional
 47-100 1.63e-04

tetratricopeptide repeat protein; Provisional


Pssm-ID: 236983 [Multi-domain]  Cd Length: 389  Bit Score: 41.72  E-value: 1.63e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 616690901  47 ANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIKLYQQALQTEIE 100
Cdd:PRK11788 193 RGDLDAARALLKKALAADPQCVRASILLGDLALAQGDYAAAIEALERVEEQDPE 246
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 12-192 1.63e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.99  E-value: 1.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   12 QNGKIEEALQALFGNIEEDPTIIENYINAGIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIKLY 91
Cdd:TIGR02917 273 QKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAIATL 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   92 QQALQTEIEQVDCNYMIGMAFNQLESFKLALPYLMTAAELDKdKDTEVQFQYGLVLCQLEMFNEAITQLKHVLTIDKNHV 171
Cdd:TIGR02917 353 SPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDP-ENAAARTQLGISKLSQGDPSEAIADLETAAQLDPELG 431

                         170       180
                  ....*....|....*....|.
gi 616690901  172 DARYNLGLAlFMKNEDIDEAI 192
Cdd:TIGR02917 432 RADLLLILS-YLRSGQFDKAL 451
TPR_17 pfam13431
Tetratricopeptide repeat;
56-89 1.74e-04

Tetratricopeptide repeat;


Pssm-ID: 433201 [Multi-domain]  Cd Length: 34  Bit Score: 37.91  E-value: 1.74e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 616690901   56 FFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIK 89
Cdd:pfam13431   1 LYLKALELDPNNADAYYNLAVLLLELGQSETALQ 34
TPR_19 pfam14559
Tetratricopeptide repeat;
47-95 1.89e-04

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 38.33  E-value: 1.89e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 616690901   47 ANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIKLYQQAL 95
Cdd:pfam14559   1 EGDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALP 49
TPR_1 pfam00515
Tetratricopeptide repeat;
171-205 2.50e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 37.40  E-value: 2.50e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 616690901  171 VDARYNLGLALFmKNEDIDEAITHFKEAVTIDPKH 205
Cdd:pfam00515   1 AKALYNLGNAYF-KLGKYDEALEYYEKALELNPNN 34
TPR_12 pfam13424
Tetratricopeptide repeat;
72-134 2.56e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.52  E-value: 2.56e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 616690901   72 YNLANVYYNQQRYQEAIKLYQQALQTEIEQVDCN--------YMIGMAFNQLESFKLALPYLMTAAELDKD 134
Cdd:pfam13424   7 NNLAAVLRRLGRYDEALELLEKALEIARRLLGPDhpltattlLNLGRLYLELGRYEEALELLERALALAEK 77
TPR_7 pfam13176
Tetratricopeptide repeat;
71-98 2.85e-04

Tetratricopeptide repeat;


Pssm-ID: 433012 [Multi-domain]  Cd Length: 36  Bit Score: 37.13  E-value: 2.85e-04
                          10        20
                  ....*....|....*....|....*...
gi 616690901   71 FYNLANVYYNQQRYQEAIKLYQQALQTE 98
Cdd:pfam13176   2 LLNLGRIYRKLGDYDEAISLYEQALALA 29
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 71-144 3.46e-04

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 40.69  E-value: 3.46e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 616690901  71 FYNLANVYYNQQRYQEAIKLYQQALQTEIEQVDCNYMIGMAFNQLESFKLALPYLMTAAELDKDKDTEVQFQYG 144
Cdd:cd24142    3 LLEKAEELLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDGGYEKYLYLG 76
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
149-212 5.13e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 38.23  E-value: 5.13e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 616690901 149 QLEMFNEAITQLKHVLTIDKNHVDARYNLGLALFMKNeDIDEAIThFKEAVTIDPKHLLSQHAL 212
Cdd:COG3063    4 KLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQG-RYDEAIA-LEKALKLDPNNAEALLNL 65
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 171-205 5.49e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.27  E-value: 5.49e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 616690901   171 VDARYNLGLAlFMKNEDIDEAITHFKEAVTIDPKH 205
Cdd:smart00028   1 AEALYNLGNA-YLKLGDYDEALEYYEKALELDPNN 34
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 51-204 5.98e-04

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 39.63  E-value: 5.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   51 EKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIKLYQQALQTeieqvdcnymigmafnqlesfklalpylmtaae 130
Cdd:TIGR02521  48 EVAKENLDKALEHDPDDYLAYLALALYYQQLGELEKAEDSFRRALTL--------------------------------- 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 616690901  131 ldKDKDTEVQFQYGLVLCQLEMFNEAITQL-KHVLTIDKNHVDARY-NLGLAlFMKNEDIDEAITHFKEAVTIDPK 204
Cdd:TIGR02521  95 --NPNNGDVLNNYGTFLCQQGKYEQAMQQFeQAIEDPLYPQPARSLeNAGLC-ALKAGDFDKAEKYLTRALQIDPQ 167
PRK11447 PRK11447
cellulose synthase subunit BcsC; Provisional
 47-96 8.26e-04

cellulose synthase subunit BcsC; Provisional


Pssm-ID: 183140 [Multi-domain]  Cd Length: 1157  Bit Score: 40.07  E-value: 8.26e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 616690901   47 ANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQEAIKLYQQALQ 96
Cdd:PRK11447  364 ANNLAQAERLYQQARQVDNTDSYAVLGLGDVAMARKDYAAAERYYQQALR 413
TPR_11 pfam13414
TPR repeat;
144-184 1.27e-03

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 35.53  E-value: 1.27e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 616690901  144 GLVLCQLEMFNEAITQLKHVLTIDKNHVDARYNLGLALFMK 184
Cdd:pfam13414   1 GDAYYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKL 41
PRK11447 PRK11447
cellulose synthase subunit BcsC; Provisional
 40-194 1.32e-03

cellulose synthase subunit BcsC; Provisional


Pssm-ID: 183140 [Multi-domain]  Cd Length: 1157  Bit Score: 39.30  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   40 AGIVLADANEIEK----AERFFQKALTIDPKNGVVFYNLANVYYNQ-----QRYQEAIKLYQQALQTEIEQVDCNYMIGM 110
Cdd:PRK11447  387 AVLGLGDVAMARKdyaaAERYYQQALRMDPGNTNAVRGLANLYRQQspekaLAFIASLSASQRRSIDDIERSLQNDRLAQ 466

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  111 AFNQLES---FKLALPYLMTAAELDKDkDTEVQFQYGLVLCQLEMFNEAITQLKHVLTIDKNHVDARYNLGLALFMKNED 187
Cdd:PRK11447  467 QAEALENqgkWAQAAELQRQRLALDPG-SVWLTYRLAQDLRQAGQRSQADALMRRLAQQKPNDPEQVYAYGLYLSGSDRD 545


                  ....*..
gi 616690901  188 iDEAITH 194
Cdd:PRK11447  546 -RAALAH 551
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 72-134 1.34e-03

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 36.16  E-value: 1.34e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 616690901   72 YNLANVYYNQQRYQEAIKLYQQALQTEIEQ---VDCNYMIGMAFNQLESFKLALPYLMTAAELDKD 134
Cdd:pfam13432   1 LALARAALRAGDYDDAAAALEAALARFPESpdaAAALLLLGLAALRQGRLAEAAAAYRAALRAAPG 66
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 138-218 1.37e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 37.28  E-value: 1.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901 138 EVQFQYGLVLCQLEMFNEAITQLKHVLTIDKNHV---DARYNLGLALFMKNeDIDEAITHFKEAVTIDPKHLLSQHALKT 214
Cdd:COG1729   31 DALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPkapDALLKLGLSYLELG-DYDKARATLEELIKKYPDSEAAKEARAR 109


                 ....
gi 616690901 215 FTKM 218
Cdd:COG1729  110 LARL 113
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 9-134 3.55e-03

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 37.58  E-value: 3.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901   9 QYIQNGKIEEALQALFGNI--EEDPTIIENYinagiVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQRYQE 86
Cdd:COG3071  202 ALIALGDHDEAERLLREALkrQWDPRLVRLY-----GRLQGGDPAKQLKRAEKWLKKHPNDPDLLLALGRLCLRNQLWGK 276

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 616690901  87 AIKLYQQALQTEiEQVDCNYMIGMAFNQLESFKLALPYLMTAAELDKD 134
Cdd:COG3071  277 AREYLEAALALR-PSAEAYAELARLLEQLGDPEEAAEHYRKALALALG 323
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 10-67 5.30e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 35.94  E-value: 5.30e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 616690901  10 YIQNGKIEEALQALFGNIEEDPTIIENYINAGIVLADANEIEKAERFFQKALTIDPKN 67
Cdd:COG4783   82 LLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
TPR_11 pfam13414
TPR repeat;
41-82 5.74e-03

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 33.60  E-value: 5.74e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 616690901   41 GIVLADANEIEKAERFFQKALTIDPKNGVVFYNLANVYYNQQ 82
Cdd:pfam13414   1 GDAYYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKLG 42
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 149-205 7.37e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 36.84  E-value: 7.37e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 616690901 149 QLEMFN--EAITQLKHVLTIDKNHVDARYNLGLALfMKNEDIDEAITHFKEAVTIDPKH 205
Cdd:cd24142   10 LLDQGNfeLALKFLQRALELEPNNVEALELLGEIL-LELGDVEEAREVLLRAIELDPDG 67
Mgr3-like cd24145
Mitochondrial inner membrane i-AAA protease supercomplex subunit Mgr3 and similar proteins; ...
 68-198 8.62e-03

Mitochondrial inner membrane i-AAA protease supercomplex subunit Mgr3 and similar proteins; Mgr3 (also called mitochondrial genome-required protein 3) is a component of the mitochondrial inner membrane i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins. The supercomplex is composed of Mgr1, Mgr3, and Yme1. Mgr3, together with Mgr1, functions in an adapter complex that targets substrates to the i-AAA protease for degradation.


Pssm-ID: 467945 [Multi-domain]  Cd Length: 307  Bit Score: 36.56  E-value: 8.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901  68 GVVFYNLANVYYNQQRYQEAIKLYQQALQTEIEQVDCNYMIGMAF---NQLESFKLALPYLMTAAELDKDKDTEVQFQYG 144
Cdd:cd24145  147 GAFLEELATAYDLYGRFCLALPLYMQALSLKGQILLSQANCHSLVlmnNEAAELALHALRKPLSSTLIEASRLPQKSRDQ 226

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690901 145 LVLCQLEMFNEAITQLKHVLTIDKNH------VDARYNLGlALFMKNEDIDEAITHFKEA 198
Cdd:cd24145  227 LLEAALKWAQKALDVAKSIKPKDRDPecdqacALALYNLG-VIAEMLGNLDEARKLYKEA 285
TPR_12 pfam13424
Tetratricopeptide repeat;
139-204 8.93e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 34.29  E-value: 8.93e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 616690901  139 VQFQYGLVLCQLEMFNEAITQLKHVLTI-----DKNHVD---ARYNLGLALFMKNeDIDEAITHFKEAVTIDPK 204
Cdd:pfam13424   5 ALNNLAAVLRRLGRYDEALELLEKALEIarrllGPDHPLtatTLLNLGRLYLELG-RYEEALELLERALALAEK 77
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 153-212 9.40e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 34.97  E-value: 9.40e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 616690901 153 FNEAITQLKHVLTIDKNHV---DARYNLGLALFMKNeDIDEAITHFKEAVTIDPKHLLSQHAL 212
Cdd:COG1729    9 YDEAIAAFKAFLKRYPNSPlapDALYWLGEAYYALG-DYDEAAEAFEKLLKRYPDSPKAPDAL 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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