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Conserved domains on  [gi|616690640|gb|KAE88209|]
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hypothetical protein W632_00533 [Staphylococcus aureus VET0402R]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442015)

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.10.60|1.10.357.10
Gene Ontology:  GO:0003700|GO:0003677|GO:0006355
PubMed:  23602932
SCOP:  4000333

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
28-152 1.05e-06

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 46.43  E-value: 1.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690640  28 FQTITVNLICDNALVHRTTFYKHFYDKYDLLEYLFNQLTKDYFAR--------DISDRLNHPFQTISDTI-NNKEDLRDI 98
Cdd:COG1309   24 YEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAAleealaaeDPRERLRALLRAYLEFLaENPALARLL 103

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 616690640  99 AEFQEEDAEFNKVLKNVcIKIMHNDIKNNRDRIDIDSDIPDNLIFYIYDSLIEG 152
Cdd:COG1309  104 LAEAAELPELRAALRAL-LRRLRALLAELLRAGGLLADVDPDALARALLALLDG 156
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
28-152 1.05e-06

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 46.43  E-value: 1.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690640  28 FQTITVNLICDNALVHRTTFYKHFYDKYDLLEYLFNQLTKDYFAR--------DISDRLNHPFQTISDTI-NNKEDLRDI 98
Cdd:COG1309   24 YEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAAleealaaeDPRERLRALLRAYLEFLaENPALARLL 103

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 616690640  99 AEFQEEDAEFNKVLKNVcIKIMHNDIKNNRDRIDIDSDIPDNLIFYIYDSLIEG 152
Cdd:COG1309  104 LAEAAELPELRAALRAL-LRRLRALLAELLRAGGLLADVDPDALARALLALLDG 156
DHAK_reg TIGR02366
probable dihydroxyacetone kinase regulator; The seed alignment for this family was built from ...
 28-68 1.05e-03

probable dihydroxyacetone kinase regulator; The seed alignment for this family was built from a set of closely related uncharacterized proteins associated with operons for the type of bacterial dihydroxyacetone kinase that transfers PEP-derived phosphate from a phosphoprotein, as in phosphotransferase system transport, rather than from ATP. Members have a TetR transcriptional regulator domain (pfam00440) at the N-terminus and sequence homology throughout.


Pssm-ID: 274100 [Multi-domain]  Cd Length: 176  Bit Score: 38.21  E-value: 1.05e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 616690640   28 FQTITVNLICDNALVHRTTFYKHFYDKYDLLEYLFNQLTKD 68
Cdd:TIGR02366  21 FHKISVSDIMQTAQIRRQTFYNHFQDKYELLSWIFETELKE 61
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
28-152 1.05e-06

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 46.43  E-value: 1.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690640  28 FQTITVNLICDNALVHRTTFYKHFYDKYDLLEYLFNQLTKDYFAR--------DISDRLNHPFQTISDTI-NNKEDLRDI 98
Cdd:COG1309   24 YEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAAleealaaeDPRERLRALLRAYLEFLaENPALARLL 103

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 616690640  99 AEFQEEDAEFNKVLKNVcIKIMHNDIKNNRDRIDIDSDIPDNLIFYIYDSLIEG 152
Cdd:COG1309  104 LAEAAELPELRAALRAL-LRRLRALLAELLRAGGLLADVDPDALARALLALLDG 156
DHAK_reg TIGR02366
probable dihydroxyacetone kinase regulator; The seed alignment for this family was built from ...
 28-68 1.05e-03

probable dihydroxyacetone kinase regulator; The seed alignment for this family was built from a set of closely related uncharacterized proteins associated with operons for the type of bacterial dihydroxyacetone kinase that transfers PEP-derived phosphate from a phosphoprotein, as in phosphotransferase system transport, rather than from ATP. Members have a TetR transcriptional regulator domain (pfam00440) at the N-terminus and sequence homology throughout.


Pssm-ID: 274100 [Multi-domain]  Cd Length: 176  Bit Score: 38.21  E-value: 1.05e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 616690640   28 FQTITVNLICDNALVHRTTFYKHFYDKYDLLEYLFNQLTKD 68
Cdd:TIGR02366  21 FHKISVSDIMQTAQIRRQTFYNHFQDKYELLSWIFETELKE 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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