|
Name |
Accession |
Description |
Interval |
E-value |
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
12-701 |
0e+00 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 667.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 12 IAKHKWSTLIAWVIIVAAiLIPLATNAPK--FDNDIKMTGLESLDTNKKIEKHFNQDSEkAQIRVVFkTTKDDGILQPSI 89
Cdd:COG2409 1 VARHRWLVLLAWLVLLVA-LGVLAPQLGGslSSNGFFLPGSESQRAADLLAEAFPESDG-ASAVVVV-EAPDGTLTDPAF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 90 TKDIKKTFDDIKKDDkHIDKISDPYENKQ---ISKDKTTAFADITYDVSQTSLKDGSRDNVKNHLKDLRDNhNVQTELTG 166
Cdd:COG2409 78 RAAVAALVARLRADP-GVAGVQDPWDDPAaglVSEDGKAALVTVTLDGDAGDEAAEAVDALRDAVAAAPAP-GLTVYVTG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 167 TGMTSTEVG-------GNSELVGIIVAFVVLLITFGSVIAAGLPIISALIGLASGVGIISLLTYVFDIPNVTLTLAVMIG 239
Cdd:COG2409 156 PAALAADLNeafeedlGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLAAFTDVSSFAPNLLTMLG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 240 LAVGIDYALFILFRYRQVMKTETDFVKGIGLAVGTAGSAVIFAGVTVVIAVCGLSLVGIDFLAVMGFASAISVIFAVFST 319
Cdd:COG2409 236 LGVGIDYALFLVSRYREELRAGEDREEAVARAVATAGRAVLFSGLTVAIALLGLLLAGLPFLRSMGPAAAIGVAVAVLAA 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 320 LTLLPALISIFHKRIkvNKLQSNFKKDIDTP-------WSKFITGNALAAVLLGLIILVAAAIPVSHMRLGIPDDGVKPA 392
Cdd:COG2409 316 LTLLPALLALLGRRV--FWPRRPRRRRAAAPesgfwrrLARAVVRRPVPVLVAAVAVLLALALPALGLRLGLPDADSLPA 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 393 DSTQKKAYDIISDKFGEGFNGqiPMLINVKDKKDDPQGLQQDLQSVYKDIKDKKNVDIVTPPQMS--KDNDYALMVVIPK 470
Cdd:COG2409 394 DSPSRQGYDALAEHFPPGSNG--PLTVVVESDDDLDPADLAALDALAAALAAVPGVASVQPPTRPegTDGDAARLQVVPD 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 471 HGPNAESTNDLVHDLRDynKDAQDKYGFKTEISGQSVINIDMSKKLNEAIPLFATVIVVLAFFLLMIVFRSILIPLKAVL 550
Cdd:COG2409 472 GDPDSPEAIDLVDRLRD--AAAPALEGAEVLVGGTTAVNIDISDALADDLPLVIPVVLGLIFLLLLLLFRSVVAPLKAVL 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 551 GFVLSLMATLGFTTFVMQDGFmkGLFGIeTTGPMLAFLPVITIGILFGLAMDYEVFLMSRIHEEYSKTGDNDYSIKVGLK 630
Cdd:COG2409 550 TNLLSLGAALGVLVLVFQHGW--LLLGF-TPGPLDSFVPLLLFVILFGLGMDYEVFLVSRIREEYDRGGGTREAVIRGLA 626
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 616690639 631 ESGPVIVAAALIMFSVFFAFVFQEDVMIKSMGMALAFGVLFDAFVVRMMLIPALTKLFGKGSWYLPAWLNR 701
Cdd:COG2409 627 RTGRVITSAALIMAAVFAAFATSPLVFLKQIGFGLAVGVLLDAFVVRMLLVPALMALLGRWNWWLPRWLDR 697
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
3-690 |
1.44e-67 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 239.38 E-value: 1.44e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 3 KFLYKMGTFIAKHKWstliAWVIIVAAILIPLATNAPK--FDNDIKM---TGLESLDTNKKIEKHFNQDSekaQIRVVFK 77
Cdd:COG1033 2 RLMERLARFILRHRK----LVLLLFLLLTLLLAYGAPKleVDTDFESllpEDDPSVQAYDEFEEEFGGDD---TVVVAVE 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 78 TTKDdgILQPSITKDIKKTFDDIKKDDkHIDKI------------------------------------------SDPYE 115
Cdd:COG1033 75 GKDD--IFTPETLEALRELTEELEEIP-GVDSVtsltnvrategtedgltveplipdelpaspeelaelrekvlsSPLYV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 116 NKQISKDKTTAFADITYDVSQTSLKDGSR---DNVKNHLKDLRDNhNVQTELTGTGMTSTEVGGNSE-------LVGIIV 185
Cdd:COG1033 152 GRLVSPDGKATLIVVTLDPDPLSSDLDRKevvAEIRAIIAKYEDP-GVEVYLTGFPVLRGDIAEAIQsdlaiffPLALLL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 186 AFVVLLITFGSVIAAGLPIISALIGLASGVGIISLLTYVFDIpnVTLTLAVMIgLAVGIDYALFILFRYRQVMKTETDFV 265
Cdd:COG1033 231 ILLLLFLFFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSP--LTILVPPLL-LAIGIDYGIHLLNRYREERRKGLDKR 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 266 KGIGLAVGTAGSAVIFAGVTVVIAVCGLSLVGIDFLAVMGFASAISVIFAVFSTLTLLPALISIFHKRIKVNKLQSNfKK 345
Cdd:COG1033 308 EALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPALLSLLPRPKPKTRRLKK-PP 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 346 DIDTPWSK---FITGNALAAVLLGLIILVAAAIPVSHMRLGIPDDGVKPADSTQKKAYDIISDKFGegfnGQIPMLINVK 422
Cdd:COG1033 387 ELGRLLAKlarFVLRRPKVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSPIRQDLDFIEENFG----GSDPLEVVVD 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 423 DKKDDP----------QGLQQDLQ------------SVYKDIK------DKKNVDI--------------------VTPP 454
Cdd:COG1033 463 TGEPDGlkdpevlkeiDRLQDYLEslpevgkvlslaDLVKELNqalnegDPKYYALpesrellaqlllllssppgdDLSR 542
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 455 QMSKDNDYALMVV-IPKHGpnAESTNDLVHDLRDYNKDAQDKYGFKTEISGQSVINIDMSKKLNEAIPLFATVIVVLAFF 533
Cdd:COG1033 543 FVDEDYSAARVTVrLKDLD--SEEIKALVEEVRAFLAENFPPDGVEVTLTGSAVLFAAINESVIESQIRSLLLALLLIFL 620
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 534 LLMIVFRSILIPLKAVLGFVLSLMATLGfttfVMqdgfmkGLFGIEttgpmLAFLPVITIGILFGLAMDYEVFLMSRIHE 613
Cdd:COG1033 621 LLLLAFRSLRLGLISLIPNLLPILLTFG----LM------GLLGIP-----LNIATAVVASIALGIGVDYTIHFLSRYRE 685
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 616690639 614 EYSKTGDNDYSIKVGLKESGPVIVAAALIMFSVFFAFVFQEDVMIKSMGMALAFGVLFdAFVVRMMLIPALTKLFGK 690
Cdd:COG1033 686 ERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLV-ALLAALLLLPALLLLLDP 761
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
51-333 |
1.32e-55 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 194.82 E-value: 1.32e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 51 ESLDTNKKIEKHFNQdSEKAQIRVVFKTTKDDGILQPSITKDIKKTFDDIKKDDKHIDKISDPYENKQ-----ISKDKTT 125
Cdd:pfam03176 8 PSVRAMDRLGAAFPQ-ADSDPIIVVVLGEGDQALGDAAAEAGYDTLVDALRADTGHVGSVQDFWGDPDtaalfVSPDGKA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 126 AFADITYDVSQ-TSLKDGSRDNVKNHLKDLRDNHNVQTELTGTGMTSTEV--GGNS-----ELVGIIVAFVVLLITFGSV 197
Cdd:pfam03176 87 AYVVVTLEGDPgTTEADESVAAVRDAVEQAPPPEGLKAYLTGPAATVADLrdAGDRdlgliEAVTLVVIFIILLIVYRSV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 198 IAAGLPIISALIGLASGVGIISLLTYVFDIP--NVTLTLAVMIGLAVGIDYALFILFRYRQVMKTETDFVKGIGLAVGTA 275
Cdd:pfam03176 167 VAALLPLLTVGLSLGAAQGLVAILAHILGIGlsTFALNLLVVLLIAVGTDYALFLVSRYREELRAGEDREEAVIRAVRGT 246
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 616690639 276 GSAVIFAGVTVVIAVCGLSLVGIDFLAVMGFASAISVIFAVFSTLTLLPALISIFHKR 333
Cdd:pfam03176 247 GKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLALLGRW 304
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
180-687 |
1.39e-35 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 144.59 E-value: 1.39e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 180 LVGIIVAfVVLLITFGSVIAAGLPIISALIGLASGVGIISLLTYVFDIpNVTLTLAVMIGlaVGIDYALFILFRYRQVMK 259
Cdd:TIGR00921 201 ISGILVV-LVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYA-TTLLAVPMLIG--VGIDYGIQTLNRYEEERD 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 260 TETDFVKGIGLAVGTAGSAVIFAGVTVVIAVCGLSLVGIDFLAVMGFASAISVIFAVFSTLTLLPA-LISIFHKRIKVNK 338
Cdd:TIGR00921 277 IGRAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPAlLQSIDIGREKVKK 356
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 339 LQSNFK------KDIDTPWSKFITGNALAAVLLGLIILVAAAIPVSHMRLGIPDDGVKPADSTQKKAYDIISDKFGeGFN 412
Cdd:TIGR00921 357 EIIAIGgksseiEEELSKVLSITVRHPVPALVAALIITGLGLYGAAGIKPEVNIEKFIPQDLPSLQARKVIESHMG-GSH 435
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 413 GQIPMLINVKDKKdDPQgLQQDLQSVYKDIKDKKNVDIVTPPQ------MSKDNDYALMVVIPKHGPNAESTNDLVHDLR 486
Cdd:TIGR00921 436 DFATILVKADDVR-DPE-LVRFMDELSRDIKATGVAARVFGAPsiidlvKEVEGLPAPERSALEPIPEDEEGGYISGGQI 513
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 487 D----YNKDAQDKY------------------GFKTEISGQSVINIDMSKKLNEAIPLFATVIVVLAFFLLMIVFRSILI 544
Cdd:TIGR00921 514 KvaviQVQLKQGEPkvqgrkilrdvqhehpppGVKVGVTGLPVAFAEMHELVNEGMRRMTIAGAILVLMILLAVFRNPIK 593
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 545 PLKAVLGFVLSLMATLGfttfVMqdgfmkGLFGIETTgPMLAflpvITIGILFGLAMDYEVFLMSRIHEEYSKTGDNDyS 624
Cdd:TIGR00921 594 AVFPLIAIGSGILWAIG----LM------GLRGIPSF-LAMA----TTISIILGLGMDYSIHLAERYFEERKEHGPKE-A 657
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 616690639 625 IKVGLKESGPVIVAAALIMFSVFFAFVFQEDVMIKSMGMALAFGVLFDAFVVrMMLIPALTKL 687
Cdd:TIGR00921 658 ITHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAA-LVVFPALLVL 719
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
391-696 |
1.23e-31 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 126.25 E-value: 1.23e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 391 PADSTQKKAYDIISDKFGEGfnGQIPMLINVKDKKDDPQGLQQDLQSVYKDI----KDKKNVDIVTPPQ---------MS 457
Cdd:pfam03176 4 PADAPSVRAMDRLGAAFPQA--DSDPIIVVVLGEGDQALGDAAAEAGYDTLVdalrADTGHVGSVQDFWgdpdtaalfVS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 458 KDNDYALMVVIPKHGPNAESTNDLVHDLRDYNKDAQDKYGFKTEISGQSVINIDMSKKLNEAIPLFATVIVVLAFFLLMI 537
Cdd:pfam03176 82 PDGKAAYVVVTLEGDPGTTEADESVAAVRDAVEQAPPPEGLKAYLTGPAATVADLRDAGDRDLGLIEAVTLVVIFIILLI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 538 VFRSILIPLKAVLGFVLSLMATLGFTTFVmQDGfmkGLFGIETTGPMLAFLpvitigILFGLAMDYEVFLMSRIHEEYSK 617
Cdd:pfam03176 162 VYRSVVAALLPLLTVGLSLGAAQGLVAIL-AHI---LGIGLSTFALNLLVV------LLIAVGTDYALFLVSRYREELRA 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 616690639 618 TGDNDYSIKVGLKESGPVIVAAALIMFSVFFAFVFQEDVMIKSMGMALAFGVLFDAFVVRmMLIPALTKLFGKGSWYLP 696
Cdd:pfam03176 232 GEDREEAVIRAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAAL-TLLPALLALLGRWGLWPP 309
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
1-335 |
2.87e-27 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 118.42 E-value: 2.87e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 1 MAKFLYKMGTFIAKHKWSTLIAwVIIVAAILIPLATNAPKFDNDIKM--TGLESLDTNKKIEKHFNQDSekaQIRVVFKT 78
Cdd:COG1033 388 LGRLLAKLARFVLRRPKVILVV-ALVLAVVSLYGISRLKVEYDFEDYlpEDSPIRQDLDFIEENFGGSD---PLEVVVDT 463
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 79 TKDDGILQPSITKDIKK------TFDDIKK-----------------DDKHIDKISDPYE-----------------NKQ 118
Cdd:COG1033 464 GEPDGLKDPEVLKEIDRlqdyleSLPEVGKvlsladlvkelnqalneGDPKYYALPESREllaqlllllssppgddlSRF 543
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 119 ISKDKTTAFADITYDVSQTSLKDGSRDNVKNHLKDLRDNHNVQTELTGTGMTSTEVGGN-------SELVGIIVAFVVLL 191
Cdd:COG1033 544 VDEDYSAARVTVRLKDLDSEEIKALVEEVRAFLAENFPPDGVEVTLTGSAVLFAAINESviesqirSLLLALLLIFLLLL 623
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 192 ITFGSVIAAGLPIISALIGLASGVGIIslltYVFDIP-NVTLTLAVMIGLAVGIDYALFILFRYRQVMKTETDFVKGIGL 270
Cdd:COG1033 624 LAFRSLRLGLISLIPNLLPILLTFGLM----GLLGIPlNIATAVVASIALGIGVDYTIHFLSRYREERRKGGDLEEAIRR 699
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 616690639 271 AVGTAGSAVIFAGVTVVIAVCGLSLVGIDFLAVMGFASAISVIFAVFSTLTLLPALISIFHKRIK 335
Cdd:COG1033 700 ALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLLDPRIA 764
|
|
| actII |
TIGR00833 |
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ... |
22-694 |
1.92e-26 |
|
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 116.22 E-value: 1.92e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 22 AWVIIVAAILIPLATN--APKFDNDIKMT-------GLESLDTNKKIEKHFNQDSEKAQIRVVFKTTKDDGILQPSI-TK 91
Cdd:TIGR00833 3 AYGIIGVWIATAISLQllAPLLEDVSYFRlqaelpgGAASSIAVKEMSAAFQEAIRDPKIILVLESNERLGDKDYATyDA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 92 DIKKTFDDIKKDDKHIDKISDPY-ENKQISKDKTTAFADITYDVSQTSLKDG-SRDNVKNHLKDLRDNHNVQTELTGTGM 169
Cdd:TIGR00833 83 LIAKLRADIMHVISVVDFWGPPEaAEGLRSDDGKATIIIVNLAGEKGQKEAQeAINAVRRIVEQTNAPDGLTVHVTGPLA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 170 T---STEVGGNS----ELVGIIVAFVVLLITFGSVIAAGLPIISALIGLASGVGIISLLTYVFDIPNVTLTLAVMIGLAV 242
Cdd:TIGR00833 163 TiadILESGDKDmnriTATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLGIPGLIGVNAQTTVLLTALVI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 243 G--IDYALFILFRYRQVMKTETDFVKGIGLAVGTAGSAVIFAGVTVVIAVCGLSLVGIDFLAVMGFASAISVIFAVFSTL 320
Cdd:TIGR00833 243 GagTDYAVFLTGRYHEERRKGESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLVALLNAV 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 321 TLLPALISIFHKR--------IKVNKLQSNFKKDID-TPWSKFITGNALAAVLLGLIILVA------AAIPVS------- 378
Cdd:TIGR00833 323 TLTPALLTLEGREglmkpgrkSKIRFIWRRLGTAVVrRPWPILVTTLIISGVSLLALPLIRtgyddeKMIPTDlesvqgy 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 379 -----H--------MRLGIPDD-----------------------GV-------KPADSTQKKAYdiISDKFGEGFNGQI 415
Cdd:TIGR00833 403 eaadrHfpgnsmdpMVVMIKSDhdvrnpalladidrfereikavpGInmvqetqRPDGVVIKKTY--LTFQAGNLGDQLD 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 416 PMLINVKDKKDD------------------PQGLQQD------------------------------------------- 434
Cdd:TIGR00833 481 EFSDQLTSRQAYllqdaekiaeaiaglrlvQAGMRLDgenlgqvslavrlmqqaisklqgsagdvfdifdplrrfvaaip 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 435 ---------------------------LQSVYKDIKDK------------------------------------------ 445
Cdd:TIGR00833 561 ecranpvcsvareivqaadtvvssaakLADAAGQLARGiadvasalsqvsglpnaldgigtqlaqmresaagvqdllnel 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 446 --------------KNVDIVTPPQMSKDNDY--------------ALMVVIPKHGPNAESTNDLVHDLRDYNKDAQDKYG 497
Cdd:TIGR00833 641 sdysmtmgklkgnaMGVDFYAPPRIFTDPNFkavldyflspdghaARLLVYGDGSPAGDQGAQEFNAIRTVAEEAIQRAD 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 498 F---KTEISGQSVINIDMSKKLNEAIPLFATVIVVLAFFLLMIVFRSILIPLKAVLGFVLSLMATLGFTTFVMQDgfmkg 574
Cdd:TIGR00833 721 LepaKVELAGVSAVNRDLRDLVNSDLGLISIITLAIVFMILALLLRAPVAPIVLIGSVALSYLWALGLSVLAFQH----- 795
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 575 LFGIEttgpMLAFLPVITIGILFGLAMDYEVFLMSRIHEEySKTGdNDYSIKVGLKESGPVIVAAALIMFSVFFAFVFQE 654
Cdd:TIGR00833 796 ILGAE----LHWSVLAGVFVLLVALGVDYNMLLVSRIKEE-SPAG-NRTGIIRALGSTGGVITAAGLVFAGTMAALASAQ 869
|
890 900 910 920
....*....|....*....|....*....|....*....|
gi 616690639 655 DVMIKSMGMALAFGVLFDAFVVRMMLIPALTKLFGKGSWY 694
Cdd:TIGR00833 870 LTAIAQFGFTVGVGILLDTFIVRSVTVPALTLLLGRWIWW 909
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
3-327 |
9.56e-19 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 91.44 E-value: 9.56e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 3 KFLYKMGTFIAKHKWSTLIAWVIIVAAIL-----IPLATNAPKFDNdikmTGLESLDTNKKIEKHFNQDSEKAQIRVvfk 77
Cdd:TIGR00921 370 EELSKVLSITVRHPVPALVAALIITGLGLygaagIKPEVNIEKFIP----QDLPSLQARKVIESHMGGSHDFATILV--- 442
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 78 ttKDDGILQPSITKDIKKTFDDIKKDDKH--------------------------IDKISDPYENKQISKDKTtAFADIT 131
Cdd:TIGR00921 443 --KADDVRDPELVRFMDELSRDIKATGVAarvfgapsiidlvkeveglpapersaLEPIPEDEEGGYISGGQI-KVAVIQ 519
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 132 YDVSQTSLKDgSRDNVknhLKDLRDNH---NVQTELTGTGMTSTEVG-------GNSELVGIIVAFVVLLITFGSVIAAG 201
Cdd:TIGR00921 520 VQLKQGEPKV-QGRKI---LRDVQHEHpppGVKVGVTGLPVAFAEMHelvnegmRRMTIAGAILVLMILLAVFRNPIKAV 595
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 202 LPIISALIGLASGVGIISLLtyvfDIPNvTLTLAVMIG--LAVGIDYALFILFRYRQVMKtETDFVKGIGLAVGTAGSAV 279
Cdd:TIGR00921 596 FPLIAIGSGILWAIGLMGLR----GIPS-FLAMATTISiiLGLGMDYSIHLAERYFEERK-EHGPKEAITHTMERTGPGI 669
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 616690639 280 IFAGVTVVIAVCGLSLVGIDFLAVMGFASAISVIFAVFSTLTLLPALI 327
Cdd:TIGR00921 670 LFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALL 717
|
|
| actII |
TIGR00833 |
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ... |
391-702 |
4.83e-17 |
|
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 129913 [Multi-domain] Cd Length: 910 Bit Score: 86.18 E-value: 4.83e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 391 PADSTQKKAYDIISDKFGEGFNGQIPMLINVKDKKDDPQGLQQDLQSVYK---DIKDK-KNVDIVTPPQM-----SKDND 461
Cdd:TIGR00833 37 PGGAASSIAVKEMSAAFQEAIRDPKIILVLESNERLGDKDYATYDALIAKlraDIMHViSVVDFWGPPEAaeglrSDDGK 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 462 yALMVVIPKHGPNAES-TNDLVHDLRDYNKDAQDKYGFKTEISGQSVINIDMSKKLNEAIPLFATVIVVLAFFLLMIVFR 540
Cdd:TIGR00833 117 -ATIIIVNLAGEKGQKeAQEAINAVRRIVEQTNAPDGLTVHVTGPLATIADILESGDKDMNRITATTGIIVLIILLLVYR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 541 SILIplkavlgfVLSLMATLGFTTfVMQDGFMkGLFGIETTGPMLAFLPVITIGILFGLAMDYEVFLMSRIHEEYSKTGD 620
Cdd:TIGR00833 196 SPIT--------MLVPLVSVGFSV-VVAQGIV-SLLGIPGLIGVNAQTTVLLTALVIGAGTDYAVFLTGRYHEERRKGES 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 621 NDYSIKVGLKESGPVIVAAALIMFSVFFAFVFQEDVMIKSMGMALAFGVLFdAFVVRMMLIPALTKLFGKGSWYLPAWLN 700
Cdd:TIGR00833 266 LEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTLGVSCAVGVLV-ALLNAVTLTPALLTLEGREGLMKPGRKS 344
|
..
gi 616690639 701 RI 702
Cdd:TIGR00833 345 KI 346
|
|
| YdfJ |
COG2409 |
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ... |
2-330 |
6.69e-15 |
|
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];
Pssm-ID: 441964 [Multi-domain] Cd Length: 697 Bit Score: 78.65 E-value: 6.69e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 2 AKFLYKMGTFIAKHKWSTLIAWVIIVAAILIPLATNAPKFDNDIKM-TGLESLDTNKKIEKHFNQDSEkAQIRVVFKTtk 80
Cdd:COG2409 346 SGFWRRLARAVVRRPVPVLVAAVAVLLALALPALGLRLGLPDADSLpADSPSRQGYDALAEHFPPGSN-GPLTVVVES-- 422
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 81 dDGILQPSITKDIKKTFDDIKKDDkHIDKISDPYENKqiSKDKTTAFADITYDVSQTSlkDGSRDnvknHLKDLRDnhNV 160
Cdd:COG2409 423 -DDDLDPADLAALDALAAALAAVP-GVASVQPPTRPE--GTDGDAARLQVVPDGDPDS--PEAID----LVDRLRD--AA 490
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 161 QTELTGtgmTSTEVGGNS--------------ELVGIIV---AFVVLLITFGSVIAAGLPIISALIGLASGVGIISLL-- 221
Cdd:COG2409 491 APALEG---AEVLVGGTTavnidisdaladdlPLVIPVVlglIFLLLLLLFRSVVAPLKAVLTNLLSLGAALGVLVLVfq 567
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 222 --TYVFDIPNVTLT-----LAVMIGLAVGIDYALFILFRYRQVMKTETDFVKGIGLAVGTAGSAVIFAGVtVVIAV-CGL 293
Cdd:COG2409 568 hgWLLLGFTPGPLDsfvplLLFVILFGLGMDYEVFLVSRIREEYDRGGGTREAVIRGLARTGRVITSAAL-IMAAVfAAF 646
|
330 340 350
....*....|....*....|....*....|....*...
gi 616690639 294 SLVGIDFLAVMGFASAISVIF-AVFSTLTLLPALISIF 330
Cdd:COG2409 647 ATSPLVFLKQIGFGLAVGVLLdAFVVRMLLVPALMALL 684
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
359-688 |
1.38e-14 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 77.96 E-value: 1.38e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 359 ALAAVLLGLIILVAAAIpvSHMRLGIPDDGVKPADSTQKKAYDIISDKFGEGfNGQIPMLINVKDKKDDP-----QGLQQ 433
Cdd:TIGR00921 6 AIILVFLALLILSAYGA--QHLNVESDTEKQLPKDFESYKWYHVLQREFGTS-TKTLLVVIEGDDVTRKPvldymRRLEQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 434 DLQSV-------------------YKDIKDKKNVDIVT---PPQ----MSKDNDYALMVVIPKHGPNAESTNDLVHDLRD 487
Cdd:TIGR00921 83 RLREKpyvtnvrsaadimrqipgnFPLPVTMPEVRPLMseyPRSkemfLSKDHTVAIIIVQLKSDADYKQVVPIYNDVER 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 488 YNKDAQDKYGFKTEISGQSVINIDMSKKLNEAIPLFATVIVVLAFFLLMIVFRSiliPLKAVLGFVLSLMATlgfttfVM 567
Cdd:TIGR00921 163 SLERTNPPSGKFLDVTGSPAINYDIEREFGKDMGTTMAISGILVVLVLLLDFKR---WWRPLLPLVIILFGV------AW 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 568 QDGFMkGLFGIETTGPMLAFLPVitigiLFGLAMDYEVFLMSRIHEEYSKTGDNDYSIKVGLKESGPVIVAAALIMFSVF 647
Cdd:TIGR00921 234 VLGIM-GWLGIPLYATTLLAVPM-----LIGVGIDYGIQTLNRYEEERDIGRAKGEAIVTAVRRTGRAVLIALLTTSAGF 307
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 616690639 648 FAFVFQEDVMIKSMGMALAFGVLFdAFVVRMMLIPALTKLF 688
Cdd:TIGR00921 308 AALALSEFPMVSEFGLGLVAGLIT-AYLLTLLVLPALLQSI 347
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
153-382 |
1.63e-12 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 71.18 E-value: 1.63e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 153 DLRDNHNVQTELTGTG------MTSTEVGGNSELVGIIVAFVVLLI----TFGSVIAAGLPIISALI---GLAS-GVGII 218
Cdd:TIGR03480 242 RLDEDHGVTVRLTGEValsdeeLATVSEGATVAGLLSFVLVLVLLWlalrSPRLVFAVLVTLIVGLIltaAFATlAVGHL 321
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 219 SLLTYVFdipnvtltlAVM-IGLavGIDYALFILFRYRQVMKTETDFVKGIGLAVGTAGSAVIFAGVTVVIAVcgLSLVG 297
Cdd:TIGR03480 322 NLISVAF---------AVLfIGL--GVDFAIQFSLRYREERFRGGNHREALSVAARRMGAALLLAALATAAGF--FAFLP 388
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 298 IDFLAV--MGFASAISVIFAVFSTLTLLPALISIFHKRIKVNKLQSNFKKDIDTpwskFITGNALAAVLLGLIILVAAAI 375
Cdd:TIGR03480 389 TDYKGVseLGIIAGTGMFIALFVTLTVLPALLRLLRPPRRRKPPGYATLAPLDA----FLRRHRRPVLGVTLILGIAALA 464
|
....*..
gi 616690639 376 PVSHMRL 382
Cdd:TIGR03480 465 LLPQLRF 471
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
180-374 |
2.27e-07 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 54.47 E-value: 2.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 180 LVGIIVAFVVLLITFGSVIAAGLPIISALIGLASGVGI-------ISLLTYVFDipnvtltlAVMIGlaVGIDYALFILF 252
Cdd:COG4258 256 LISLLGILLLLLLVFRSLRPLLLGLLPVAVGALAGLAAvslvfgsVHGITLGFG--------SSLIG--VAVDYSLHYLT 325
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 253 RYR--------QVMKtetDFVKGIGLAVGTAgsavifagvtvVIAVCGLSLVGIDFLAVMGFASAISVIFAVFSTLTLLP 324
Cdd:COG4258 326 HRRaagewdprAALR---RIWPTLLLGLLTT-----------VLGYLALLFSPFPGLRQLGVFAAAGLLAAALTTLLWLP 391
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 616690639 325 ALISifHKRIKVNKLQSNFkkdIDTPWSKFITGNALAAVLLGLIILVAAA 374
Cdd:COG4258 392 LLLP--RAAPRPPAPALAL---LARLLARWPRRLRWLLALLAVLALASLL 436
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
473-688 |
2.27e-07 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 54.62 E-value: 2.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 473 PNAESTNDLVHDLRDYNKDAqdKYGFKTEISGQSVINIDMSKKLNEAIPLFATVIVVLAFFLLMIVFRSILIPLKAVLGF 552
Cdd:TIGR03480 226 PAEKAINAIRAAAKDLRLDE--DHGVTVRLTGEVALSDEELATVSEGATVAGLLSFVLVLVLLWLALRSPRLVFAVLVTL 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 553 VLSLMATLGFTTFvmqdgfmkglfgiettgpMLAFLPVITIG--ILF-GLAMDYEVFLMSRIHEEYSKTGDNDYSIKVGL 629
Cdd:TIGR03480 304 IVGLILTAAFATL------------------AVGHLNLISVAfaVLFiGLGVDFAIQFSLRYREERFRGGNHREALSVAA 365
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 616690639 630 KESGPVIVAAALIMFSVFFAFVFQEDVMIKSMGMALAFGVlFDAFVVRMMLIPALTKLF 688
Cdd:TIGR03480 366 RRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGM-FIALFVTLTVLPALLRLL 423
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
180-325 |
2.54e-05 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 47.92 E-value: 2.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 180 LVGIIVAFVVLLITFGSVIAAGLPIISALIGLASGVGIISLLTYVFDIPNVtltLAVMIGLAVGIDYALFILfryRQVMK 259
Cdd:COG4258 646 LLALLLILLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHL---IALLLVLGIGIDYALFFT---EGLLD 719
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 616690639 260 TETDfvkgiglavGTAGSAVIFAGVTVVIAVCGLSLVGIDFLAVMGFASAISVIFAVFSTLTLLPA 325
Cdd:COG4258 720 KGEL---------ARTLLSILLAALTTLLGFGLLAFSSTPALRSFGLTVLLGILLALLLAPLLAPR 776
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
456-703 |
2.99e-05 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 47.54 E-value: 2.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 456 MSKDNDYALMVVIPKHGPNAESTND-LVHDLRDYNKDAQDKY-GFKTEISGQ---SVINIDMSKKLNEAIPLFATVIVVL 530
Cdd:COG4258 185 VSRDGTWALLLAETRASGFDTDAQQqLVAALRAAFAALNAAFpGAQLLLTGAglfAVAAAQQIKHDISTIGLISLLGILL 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 531 affLLMIVFRSILIPLkavLGFvLSLmaTLGfttfvmqdgfmkGLFGIETTgpMLAF--LPVITIGI---LFGLAMDYEV 605
Cdd:COG4258 265 ---LLLLVFRSLRPLL---LGL-LPV--AVG------------ALAGLAAV--SLVFgsVHGITLGFgssLIGVAVDYSL 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 606 -FLMSRIHEEysktgdnDYSIKVGLKESGPVIVAAALIMFSVFFAFVFQEDVMIKSMGMALAFGVLFdAFVVRMMLIPAL 684
Cdd:COG4258 322 hYLTHRRAAG-------EWDPRAALRRIWPTLLLGLLTTVLGYLALLFSPFPGLRQLGVFAAAGLLA-AALTTLLWLPLL 393
|
250 260
....*....|....*....|
gi 616690639 685 -TKLFGKGSWYLPAWLNRII 703
Cdd:COG4258 394 lPRAAPRPPAPALALLARLL 413
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
511-701 |
4.14e-05 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 47.29 E-value: 4.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 511 DMSKKLNEAIplfatVIVVLAFFLLMIVFRSILIPLKAVlgfVLSLMATLgfttfvmqdGFMKGL-FGIETtgpMLAFLP 589
Cdd:pfam00873 332 EVVKTLLEAI-----VLVILVMFLFLQNWRATLIPAIAI---PLSLLGTF---------AVMKAFgFSINT---LTLGGL 391
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 590 VITIGILfglaMDYEVFLMSRIHEEYSKTG-DNDYSIKVGLKESGPVIVAAALIMFSVFFAFVFQEDV---MIKSMGMAL 665
Cdd:pfam00873 392 VLAIGLV----VDDAIVVVENIERVLEENGlKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLtgrIFRQFAITI 467
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 616690639 666 AFGVLFDAFVVrMMLIPALTKLFGKGS-----WYLPAWLNR 701
Cdd:pfam00873 468 VLAILLSVLVA-LTLTPALCATLLKPRrepkhGGFFRWFNR 507
|
|
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
180-380 |
4.44e-05 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 47.33 E-value: 4.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 180 LVGIIVAFVVLLITFGSVIAAglpIISAL-IGLASGVGIISLltYVFDIPNVTLTL---AVMIGLAVgiDYAL----FIL 251
Cdd:COG3696 342 LEGALLVILVLFLFLGNLRAA---LIVALaIPLSLLFAFIVM--RLFGISANLMSLgglAIDFGIIV--DGAVvmveNIL 414
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 252 FRYR--QVMKTETDFVKGIGLAVGTAGSAVIFAgvTVVIAVCGL---SLVGID--FLAVMGFASAISVIFAVFSTLTLLP 324
Cdd:COG3696 415 RRLEenRAAGTPRERLEVVLEAAREVRRPIFFA--TLIIILVFLpifTLEGVEgkLFRPMALTVIFALLGALLLSLTLVP 492
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 616690639 325 ALISIF---HKRIKVNKLqSNFKKDIDTPWSKFITGNALAAVLLGLIILVAAAIPVSHM 380
Cdd:COG3696 493 VLASLLlrgKVPEKENPL-VRWLKRLYRPLLRWALRHPKLVLAVALVLLVLALALFPRL 550
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
154-327 |
5.09e-05 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 46.91 E-value: 5.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 154 LRDNHNVQTELTGTGMTSTEvGGNSELVGIIVAF--------VVLLITFGSVIAAGLPIISALIGLASGVGIISLLTYVF 225
Cdd:TIGR03480 686 VRAVRKVAPDATGAPVSILE-SGDTVVGAFLQAFiyalvaitVLLLLTLRRVRDVLLVLAPLLLAGLLTVAAMVLLGIPF 764
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 226 DIPNVtLTLAVMIGlaVGIDYALFILFRYRQVMKTetdfvkGIGLAVGTAgSAVIFAGVTVVIAVCGLSLVGIDFLAVMG 305
Cdd:TIGR03480 765 NFANI-IALPLLLG--LGVDFGIYMVHRWRNGVDS------GNLLQSSTA-RAVFFSALTTATAFGSLAVSSHPGTASMG 834
|
170 180
....*....|....*....|..
gi 616690639 306 FASAISVIFAVFSTLTLLPALI 327
Cdd:TIGR03480 835 ILLSLGLGLTLLCTLIFLPALL 856
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
180-374 |
1.40e-04 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 45.48 E-value: 1.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 180 LVGIIVAFVVLLITFGSVIAAGLPIISALIGLASGVGIISLLTYVFDIpnvtLTLAVMIgLAVGI--DYALFIL---FRY 254
Cdd:COG0841 338 LEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNI----LTLFALV-LAIGIvvDDAIVVVeniERH 412
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 255 RQvmktetdfvKGIG------LAVGTAGSAVIFAGVTVVIAVCGLSLV-GI--DFLAVMGFASAISVIFAVFSTLTLLPA 325
Cdd:COG0841 413 ME---------EGLSpleaaiKGAREVAGAVIASTLTLVAVFLPLAFMgGItgQLFRQFALTVAIALLISLFVALTLTPA 483
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 616690639 326 LISIF---HKRIKVNKLQSNFKKDID------TPWSKFITGNALAAVLLGLIILVAAA 374
Cdd:COG0841 484 LCARLlkpHPKGKKGRFFRAFNRGFDrltrgyGRLLRWALRHRKLTLLVALALLALSV 541
|
|
| PRK14726 |
PRK14726 |
protein translocase subunit SecDF; |
166-333 |
2.30e-04 |
|
protein translocase subunit SecDF;
Pssm-ID: 237805 [Multi-domain] Cd Length: 855 Bit Score: 44.71 E-value: 2.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 166 GTGMTSTEVGGNSELVGII--VAFVVLLITFGSVIAaglpIISALIGLASGVGIISLLtyvfdipNVTLTL------AVM 237
Cdd:PRK14726 365 GLGADSIAAGLVAGLIAAIlvAALMIGFYGFLGVIA----VIALIVNVVLIIAVLSLL-------GATLTLpgiagiVLT 433
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 238 IGLAVgiDYALFILFRYRQVMKTETDFVKGIGLAVGTAGSAVIFAGVTVVIAVCGLSLVGIDflAVMGFAS--AISVIFA 315
Cdd:PRK14726 434 IGMAV--DSNVLIYERIREEEKTGHSLIQALDRGFSRALATIVDANVTILIAAVILFFLGSG--AVRGFAVtlAVGILTT 509
|
170
....*....|....*...
gi 616690639 316 VFSTLTLLPALISIFHKR 333
Cdd:PRK14726 510 VFTAFTLTRSLVAVWLRR 527
|
|
| PRK09577 |
PRK09577 |
multidrug efflux RND transporter permease subunit; |
495-684 |
4.10e-04 |
|
multidrug efflux RND transporter permease subunit;
Pssm-ID: 169981 [Multi-domain] Cd Length: 1032 Bit Score: 44.07 E-value: 4.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 495 KYGFKTEISgqSVINIDMSKKLNEAIPlfATVIVVLAFFLLMIVFRSILIPLKAV---LGFVLSLMATLGFTTFVMQdgf 571
Cdd:PRK09577 321 KYQIPYETS--SFVRVSMNKVVTTLIE--AGVLVFLVMFLFMQNFRATLIPTLVVpvaLLGTFGVMLAAGFSINVLT--- 393
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 572 mkgLFGIettgpmlaflpVITIGILfglaMDYEVFLMSRIHEEYSKTGDNDYSIKV-GLKESGPVIVAAALIMFSVFFAF 650
Cdd:PRK09577 394 ---MFGM-----------VLAIGIL----VDDAIVVVENVERLMVEEGLSPYDATVkAMKQISGAIVGITVVLTSVFVPM 455
|
170 180 190
....*....|....*....|....*....|....*..
gi 616690639 651 VFQEDV---MIKSMGMALAFGVLFDAFVVrMMLIPAL 684
Cdd:PRK09577 456 AFFGGAvgnIYRQFALSLAVSIGFSAFLA-LSLTPAL 491
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
195-329 |
5.90e-04 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 43.72 E-value: 5.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 195 GSVIAAGLPIISalIGLASGVGIISLLTYVFdipNVTLTLAV-MIGLAVGIDYALFILFRYRQVMKtETDFVKGIGLAVG 273
Cdd:TIGR00918 427 GSVGLAGVLLVA--LSVAAGLGLCALLGISF---NAATTQVLpFLALGVGVDDVFLLAHAFSETGQ-NIPFEERTGECLK 500
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 616690639 274 TAGSAVIFAGVTVVIAVCGLSLVGIDFLAVMGFASAISVIFAVFSTLTLLPALISI 329
Cdd:TIGR00918 501 RTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSL 556
|
|
| RhaT |
COG0697 |
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ... |
179-327 |
2.89e-03 |
|
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];
Pssm-ID: 440461 [Multi-domain] Cd Length: 290 Bit Score: 40.60 E-value: 2.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 179 ELVGIIVAFV-VLLITFGSVIAAGLPIISALIGLASGV--GIISLLT--YVFDIPNVTLTLAVMIGLAVGIdyALFILFR 253
Cdd:COG0697 122 RWLGLLLGFAgVLLIVGPGGGGGGGSLLGDLLALLAALswALYTVLTrrLSRRLDPLTLTFWQMLVGALLL--LPLALLT 199
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 616690639 254 YRQVMKTETDFvkGIGLAVGTAGSAVIFAGVTVVIAVCGLSLVGIDFLAVMGFASAISVIFA--VFSTLTLLPALI 327
Cdd:COG0697 200 GLPLPLSAAAW--LALLYLGLFGTALAYLLWFRALRRLGASRAAPLTYLEPVFAVLLGWLLLgePLTPLQLLGAAL 273
|
|
| EcfT |
cd16914 |
T component of ECF-type transporters; The transmembrane component (T component) of the energy ... |
512-612 |
3.56e-03 |
|
T component of ECF-type transporters; The transmembrane component (T component) of the energy coupling-factor (ECF)-type transporter is a transmembrane protein important for vitamin uptake in prokaryotes. In addition to the T component, energy-coupling factor (ECF) transporters contain an energy-coupling module that consists of two ATP-binding proteins (known as the A and A' components) and a substrate-binding (S) component. ECF transporters comprise a subgroup of ATP-binding cassette (ABC) transporters that do not make use of water-soluble substrate binding proteins or domains, but instead employ integral membrane proteins for substrate binding, the S component, in contrast to classical ABC importers. The T component links the S component to the ATP-binding subcomplex that is composed of the A and A' components.
Pssm-ID: 410987 Cd Length: 233 Bit Score: 39.83 E-value: 3.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 512 MSKKLNEAIPLFATVIVVLAFFLLMIVFRSILIPLKAVLGFVLSLMatLGFTTFVMQDGFMKGLFGIETTGPMLA----- 586
Cdd:cd16914 19 LLPSLLLLLLLLLLLLLLLLLAGLPLRLLRLLKRLLFLLLFLLLIL--LLLPLGGGGGVFGLGGLGITLEGLLYAlllal 96
|
90 100
....*....|....*....|....*....
gi 616690639 587 -FLPVITIGILFGLAMDYEVFL--MSRIH 612
Cdd:cd16914 97 rLLAIVLAALLLLLTTPPSELLaaLRRLG 125
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
183-330 |
4.69e-03 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 40.64 E-value: 4.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 183 IIVAFVVLLITFGSVIAAGLPIISALIGLASGVGIISLLTYVFD-IPNVTLTLAVMIGLAVGIDYALfilfryrQVMKTE 261
Cdd:TIGR00918 975 LACTFLVCALLLLNPWTAGLIVLVLALMTVELFGMMGLLGIKLSaIPVVILIASVGIGVEFTVHIAL-------GFLTAI 1047
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 262 TDFVKGIGLAVGTAGSAVIFAGVTVVIAVCGLSLVGIDFLAVMGFAS-AISVIFAVFSTLTLLPALISIF 330
Cdd:TIGR00918 1048 GDRNRRAVLALEHMFAPVLDGALSTLLGVLMLAGSEFDFIVRYFFAVlAVLTCLGVLNGLVLLPVLLSMF 1117
|
|
| NodJ |
COG3559 |
Putative exporter of oligosaccharides and polyketide antibiotics DrrB/NodJ, ABC-2 family ... |
180-326 |
5.48e-03 |
|
Putative exporter of oligosaccharides and polyketide antibiotics DrrB/NodJ, ABC-2 family [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 442780 [Multi-domain] Cd Length: 529 Bit Score: 40.23 E-value: 5.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 180 LVGIIVAFVVLLITFGSV------IAAGLPIISALIG-LASGVGII-SLLTyvfdipnvtlTLAVMIGLAVGIdYALFIL 251
Cdd:COG3559 294 LIGWAIGLAVLGLAYGSLagsvgdLLEDNPALAELLArLGGGASLVdAFLA----------TLLGILAILAAA-YAVQAV 362
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 252 FRYRQvmkTETDFVKGIGLAVGT-----AGS--AVIFAGVTVVIAVCGLSLvGIDFLAVMGFASAISVIFAvfSTLTLLP 324
Cdd:COG3559 363 LRLRA---EETSGRAEPLLATAVsrtrwLAShlAVAALGSAVLLLVAGLGL-GLGAAAVTGDPGSLGRLLG--AALAQLP 436
|
..
gi 616690639 325 AL 326
Cdd:COG3559 437 AV 438
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
180-375 |
6.85e-03 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 39.97 E-value: 6.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 180 LVGIIVAFVVLLITFGSVIAAGLPIISalIGLASGVGIISLLTYVFDIPNVTL-TLAVMIGLAVgiDYALFILFR-YRQV 257
Cdd:pfam00873 338 LEAIVLVILVMFLFLQNWRATLIPAIA--IPLSLLGTFAVMKAFGFSINTLTLgGLVLAIGLVV--DDAIVVVENiERVL 413
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 258 MKTETDFVKGIGLAVGTAGSAVIFaGVTVVIAVCG--LSLVGID--FLAVMGFASAISVIFAVFSTLTLLPALISIF--- 330
Cdd:pfam00873 414 EENGLKPLEAAYKSMGEIGGALVA-IALVLSAVFLpiLFLGGLTgrIFRQFAITIVLAILLSVLVALTLTPALCATLlkp 492
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 616690639 331 HKRIKVNKLQSNFKKDIDtpWSKFITGNALAAVLLG-LIILVAAAI 375
Cdd:pfam00873 493 RREPKHGGFFRWFNRMFD--RLTRGYAKLLAKVLRHtAVVLLVALL 536
|
|
| NhaC |
COG1757 |
Na+/H+ antiporter NhaC/MleN [Energy production and conversion]; |
175-331 |
9.81e-03 |
|
Na+/H+ antiporter NhaC/MleN [Energy production and conversion];
Pssm-ID: 441363 [Multi-domain] Cd Length: 418 Bit Score: 39.16 E-value: 9.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 175 GGNSELVGIIVAFVVLLItFGSVIAAGLPI-ISALIGLASGVGIISLLTYVFDipnvTLTLAVMIGLAVGIdYALFILFr 253
Cdd:COG1757 23 AIVWEALLPILVLIVVLV-VGVLLYTGLALhIGLLIGLIVAALLGLRKGLSWK----EIEEGIIEGIKSML-PAILILL- 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 616690639 254 yrqvmktetdfvkgiglAVGTAGSAVIFAGVTVVIAVCGLSLVGIDFLAVMGFasAISVIFAV-----FSTL-TLLPALI 327
Cdd:COG1757 96 -----------------LAGALIGVWIALGTVPYLIYYGLGLLSPSLFPAAAF--LLCAIISFatgtsWGTFgTLGPALM 156
|
....
gi 616690639 328 SIFH 331
Cdd:COG1757 157 GIAA 160
|
|
| |
